metaR UMPK2n
name: UMP kinase (CTP),nuclear
is: SBO:0000176
product: MODEL1310110020#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_934b94cb_d41e_42c0_9603_6529bf37b70e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ACOT1
initial amount: NaN
constant: false
type: Species
is: E9KL42
is encoded by: hsa:641371
has only substance units: false

metaR RBTt
reactant: MODEL1310110020#
name: ribitol transport via passive diffusion
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

metaM ksi pre28 g
is: SBO:0000247
boundary condition: false
is: HMDB00175
is: CHEBI:58053
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 28
initial amount: NaN
is: C00130

metaM ksi deg22 l
is: SBO:0000247
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 22
type: Species
initial amount: NaN
is: CHEBI:16953
initial concentration: 1.0
constant: false
is: HMDB00812

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR CYOR u10m
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR CYTK2
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176
name: cytidylate kinase (dCMP)

http://identifiers.org/biomodels.db/MODEL1310110020#_245c26eb_22c5_4cdb_a434_c2d8a97912e6
is: P21953
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: BCKDHB
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:594
type: Species

metaR r1654
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_82d6325b_51a1_4673_b658_3ae4e5b0180c
type: Species
name: CHAT
is: Q6LEN5
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103

metaM dcacoa c
initial amount: NaN
initial concentration: 1.0
is: HMDB06404
is: C05274
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
type: Species
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_3be90175_dbda_4a88_972b_b9869e2c030c
constant: false
has only substance units: false
is: Q9UN42
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATP1B4
is encoded by: hsa:23439
type: Species
is: SBO:0000252

metaR CYTK11
name: cytidylate kinase (dCMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110020#

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
initial concentration: 1.0
is: CHEBI:17625
name: dUTP
has only substance units: false
is: SBO:0000247
is: HMDB01191
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_141133fb_49b6_416f_ba07_147f7afe00b8
is encoded by: hsa:AI440329
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: _AI440329_1_r
is: SBO:0000252

metaM drib e
has only substance units: false
is: CHEBI:28816
initial amount: NaN
is: HMDB03224
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 2-deoxy-D-ribose
constant: false
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801

metaM octdececrn c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06351
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3a56b248_7aae_40d4_ba44_e9fbebcd7e79
initial amount: NaN
name: SUCLG2:SUCLG1
constant: false
boundary condition: true
has part: Q96I99
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8801
has only substance units: false
has part: P53597
is encoded by: hsa:8802

metaR DADA
type: Reaction
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
name: Deoxyadenosine deaminase
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is described by: ECO:0000269

metaR ACACT10m
kinetic law: MODEL1310110020#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110020#
reversible: true
fast: false
is described by: ECO:0000134
modifier: MODEL1310110020#

metaM pyr e
has only substance units: false
type: Species
initial concentration: 1.0
name: pyruvate
boundary condition: false
constant: false
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
is: CHEBI:15361
is: SBO:0000247

metaR DLNLCGt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM din c
constant: false
initial amount: NaN
is: HMDB00071
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28997
name: Deoxyinosine
is: C05512
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR CSPG Etly
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: chondroitin sulfate E transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r1653
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#

metaM cyan e
is: HMDB02084
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
initial amount: NaN
is: CHEBI:18407
name: hydrogen cyanide
initial concentration: 1.0
boundary condition: false

metaR G6PDH1rer
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
reactant: MODEL1310110020#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum

metaR CYTK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110020#
name: cytidylate kinase (CMP)(GTP)
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_f21da704_ca9f_43c5_a99e_c20380d8e911
is: Q5HYI4
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: SQLE
constant: false
is encoded by: hsa:6713

metaM m2emgacpail hs r
is: CHEBI:24636
constant: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
initial concentration: 1.0
is: C00080
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

metaR PYAM5POr
type: Reaction
is described by: ECO:0000269
name: pyridoxamine 5'-phosphate oxidase
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
fast: false
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#

metaR CYTK10
is described by: ECO:0000269
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: cytidylate kinase (CMP,dGTP)

metaM 35cgmp c
is: CHEBI:57746
name: 3',5'-cyclic GMP(1-)
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01314
boundary condition: false

metaM dhcholestanate x
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
initial concentration: 1.0
is: HMDB00359
initial amount: NaN
is: SBO:0000247
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_511fd0a3_498d_413a_8be1_b3634322c00f
name: SLCO2A1
is: Q92959
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6578
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_30dde3d3_d623_465e_bdb7_6ba1eb2216c6
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: _T83654_1_m
initial concentration: NaN
constant: false
is encoded by: hsa:T83654
is: SBO:0000252

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
is: CHEBI:57945
boundary condition: false
constant: false
type: Species

metaM fad x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
is: HMDB01248
has only substance units: false
boundary condition: false
constant: false
type: Species
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247

metaR FAOXC16180m
name: Beta oxidation fatty acid
kinetic law: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110020#

metaR FOLt2le
reactant: MODEL1310110020#
reversible: true
name: folate transport via anion exchange
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110020#_a027a76d_a7cb_4950_8f2f_746e9caa9368
name: SLC40A1
initial concentration: NaN
is encoded by: hsa:30061
boundary condition: true
initial amount: NaN
is: Q9NP59
is: SBO:0000252
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_2a77d644_9f03_4652_aeee_9c5b566b4acf
constant: false
initial amount: NaN
name: CS
is: O75390
has only substance units: false
type: Species
is encoded by: hsa:1431
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR LNLCCPT1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110020#
fast: false
reversible: false
type: Reaction
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110020#_3b642ac4_d3ba_4a6c_8477_ce31c0fcc765
is: Q06520
boundary condition: true
name: SULT2A1
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6822

metaM CE5161 r
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
constant: false
initial concentration: 1.0
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57923

metaM HC01231 c
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58480
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_e388d303_b695_43ec_8d32_df29f880537a
constant: false
is encoded by: hsa:5238
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: B4DX94
name: PGM3
type: Species
initial amount: NaN

metaM pyr c
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
is: SBO:0000247
type: Species
name: pyruvate
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00243
is: C00022
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1

metaR NAGAlby
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
name: N-acetylgalactosaminidase, beta-
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM drib c
is: CHEBI:28816
initial amount: NaN
initial concentration: 1.0
is: HMDB03224
boundary condition: false
name: 2-deoxy-D-ribose
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
type: Species
constant: false

metaR CYTK1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110020#
name: cytidylate kinase (CMP)
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
is: SBO:0000176
fast: false

metaR r1788
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NACHEX22ly
product: MODEL1310110020#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
kinetic law: MODEL1310110020#

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN
is: HMDB00071
type: Species
is: CHEBI:28997
boundary condition: false
has only substance units: false
is: C05512
is: SBO:0000247
name: Deoxyinosine
initial concentration: 1.0
constant: false

metaR r1651
reactant: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110020#
product: MODEL1310110020#

metaM cyan c
has only substance units: false
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
name: hydrogen cyanide
constant: false
type: Species
is: CHEBI:18407
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR FAOXC184C164x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR APOCF
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
name: Apocarboxylase formation
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_3f296f17_ce95_4ed0_b80c_7f80b4b91c39
name: CYP1A2
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P05177
is encoded by: hsa:1544
constant: false
boundary condition: true

metaR FAOXC180
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
modifier: MODEL1310110020#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#

metaR EX htaxol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

metaR B3GNT39g
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110020#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110020#

metaR S3TASE1ly
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR ADSL2
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
name: adenylosuccinate lyase
product: MODEL1310110020#
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9f3e88ac_017a_4705_b8f4_b424ae8fa126
name: COX6C
is encoded by: hsa:1345
constant: false
type: Species
boundary condition: true
is: P09669
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR MI145PK
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.127
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: inositol-1,4,5-trisphosphate 3-kinase
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110020#

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
name: reverse-triiodthyronine
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28774
constant: false

metaR NDPK8n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_02e1c015_b9be_4912_8b2e_cc5fedf1bf79
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: P21399
initial concentration: NaN
name: ACO1
is encoded by: hsa:48

http://identifiers.org/biomodels.db/MODEL1310110020#_1ad83321_5443_4e19_80b3_be1dfa2fe495
boundary condition: true
has only substance units: false
constant: false
is: Q99798
initial amount: NaN
is encoded by: hsa:50
is: SBO:0000252
initial concentration: NaN
name: ACO2
type: Species

metaM dcsptn1coa x
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06513
is: C16173
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

metaM dpcoa m
name: 3'-dephospho-CoA(2-)
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01373

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_d2022cf3_5b95_44fd_b56c_4b1f23de639a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: AADAT
has only substance units: false
constant: false
is: Q4W5N8
initial amount: NaN
is encoded by: hsa:51166

metaM nadh r
is: HMDB01487
name: NADH(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: CHEBI:57945
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaR G3PD1
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
reversible: true

metaR r2318
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: true
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaM fad r
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
has only substance units: false
is: CHEBI:16238
boundary condition: false
name: Flavin adenine dinucleotide oxidized
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
reversible: true

metaR r1787
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaR GPIDAer
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
fast: false
type: Reaction
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR ADSL1
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_f38b52e1_7ff7_430a_a7f5_4a8919a61ded
name: ACOX3
boundary condition: true
is: O15254
is encoded by: hsa:8310
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR DNDPt14m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: dUDP transport via dTDP antiport

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR ARACHCRNt
name: transport into the mitochondria (carnitine)
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is: SBO:0000185
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM HC02214 c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
is: SBO:0000247
boundary condition: false
is: CHEBI:28852
type: Species
initial concentration: 1.0

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
constant: false
is: C00021
is: CHEBI:16680
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00939
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5ac71d42_1551_4162_962d_d127d4e96cf2
boundary condition: true
is encoded by: hsa:5151
type: Species
initial concentration: NaN
initial amount: NaN
name: PDE8A
has only substance units: false
constant: false
is: SBO:0000252

metaR CITtbm
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
fast: false
is described by: ECO:0000269
name: citrate transport, mitochondrial
reversible: true
is: SBO:0000185
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1da46f5c_8be8_4683_b147_cd430d8d7d30
constant: false
initial concentration: NaN
name: ADCY9
type: Species
initial amount: NaN
is: O60503
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:115

metaR r1657
fast: false
type: Reaction
modifier: MODEL1310110020#
reversible: true
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR XYLTD Dr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110020#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r1786
product: MODEL1310110020#
modifier: MODEL1310110020#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r2319
product: MODEL1310110020#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#

metaR SERATB0tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Serine into the intestinal cells by ATB0 transporter
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR RDH2
reversible: true
is: SBO:0000176
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
modifier: MODEL1310110020#

metaR HGNTOR
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110020#
is described by: ECO:0000269
fast: false
reversible: false
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110020#
is: SBO:0000176
type: Reaction

metaR EHGLAT2m
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L

metaM apoC Lys m
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32551
is: HMDB00182
type: Species
name: Apocarboxylase (Lys residue)
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false

metaM dutp n
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
constant: false
initial concentration: 1.0
is: HMDB01191
boundary condition: false
is: CHEBI:17625
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaM fgam c
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: SBO:0000247
has only substance units: false
is: C04376
is: HMDB01308
is: CHEBI:58426

http://identifiers.org/biomodels.db/MODEL1310110020#_0841e76c_0933_4b8a_a3df_3298b783e004
name: GALNT5
constant: false
boundary condition: true
is: A5PKZ1
is encoded by: hsa:11227
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR SERDGLYexR
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110020#
reversible: true
name: D-Serine/Glycine reversible exchange
kinetic law: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#

metaR r2316
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#
is: SBO:0000185

metaR PHACCOAGLNAC
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110020#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
type: Species
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57767

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR PI345P5P
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false

metaM tetpent6coa x
is: C16172
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR r1656
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_6d98af4e_0e0f_4741_b132_218423540ef9
type: Species
initial concentration: NaN
is: Q6LEN6
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CHAT
constant: false
has only substance units: false
is encoded by: hsa:1103

metaM dece3coa x
has only substance units: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR RDH3
product: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
name: retinol dehydrogenase (11-cis,NADH)

http://identifiers.org/biomodels.db/MODEL1310110020#_afc08405_529f_4500_a5a0_fb4531f352c9
initial amount: NaN
type: Species
is encoded by: hsa:30814
is: Q9NZK7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PLA2G2E
constant: false
has only substance units: false

metaR RE2269E
is version of: http://identifiers.org/ec-code/3.4.21.39
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
type: Reaction
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false

metaR LINKDEG2ly
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110020#

metaR DCK2n
name: Deoxycytidine kinase, nuclear (UTP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269

metaR RE3218C
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
name: RE3218
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
product: MODEL1310110020#

metaR OMHPALTD
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM dpcoa l
boundary condition: false
initial concentration: 1.0
is: HMDB01373
is: SBO:0000247
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
initial amount: NaN
name: 3'-dephospho-CoA(2-)
type: Species
has only substance units: false

metaR r2317
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM tettet6coa x
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
type: Species
constant: false
is: HMDB06516
is: C16171
is: SBO:0000247
name: tetracosatetraenoyl coenzyme A
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205481
initial amount: NaN

metaR PRAGSr
reactant: MODEL1310110020#
name: phosphoribosylglycinamide synthase
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaM ahcys e
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
type: Species
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16680
is: C00021
initial concentration: 1.0

metaR r0399
modifier: MODEL1310110020#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2

metaM strdnccoa x
constant: false
is: http://identifiers.org/pubchem.compound/47205473
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
is: C16163
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: stearidonyl coenzyme A
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b32cf509_e036_4f0e_8ad1_db863ef23dd6
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1337
has only substance units: false
initial concentration: NaN
is: P12074
initial amount: NaN
name: COX6A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_b7ce9cff_7bcc_4f4b_bb3a_a0abe1ed4f62
is encoded by: hsa:8694
name: DGAT1
is: O75907
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4372a331_32eb_4350_98f9_75b5693889d3
type: Species
initial concentration: NaN
is: SBO:0000252
is: P02730
name: SLC4A1
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:6521

metaR TTDCRNt
name: transport into the mitochondria (carnitine)
reversible: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110020#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000

metaR r1655
modifier: MODEL1310110020#
fast: false
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR EX perillyl LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Perillyl alcohol exchange
type: Reaction

metaM cs a l
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
is: HMDB02183
is: CHEBI:36005
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:17625
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: dUTP
is: HMDB01191
is: C00460

metaR r2314
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#

metaR FAOXC184C164m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM hs deg16 l
name: heparan sulfate, degradation product 16
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02704
is: CHEBI:21338
is: SBO:0000247
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_00e5fead_54a8_42ed_ac02_792f2c7607ae
is: P14555
has only substance units: false
constant: false
is encoded by: hsa:5320
initial amount: NaN
initial concentration: NaN
name: PLA2G2A
boundary condition: true
is: SBO:0000252
type: Species

metaM andrstandn r
constant: false
is: CHEBI:15994
has only substance units: false
name: 5alpha-androstane-3,17-dione
initial concentration: 1.0
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: HMDB00899
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM dgmp m
is: CHEBI:57673
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00362
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
name: dGMP
boundary condition: false
is: HMDB01044

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR DNDPt25m
product: MODEL1310110020#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
name: dTDP transport via dCDP antiport
type: Reaction
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM estradiol r
name: estradiol
is: CHEBI:16469
constant: false
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
type: Species
is: HMDB00151
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM CE0849 m
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species

metaM mi1p D c
has only substance units: false
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false
constant: false
type: Species
is: CHEBI:58433
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: HMDB02985

metaM dlnlcgcoa r
is: SBO:0000247
is: CHEBI:27979
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: C03595

metaR TDCHOLAtx
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000185
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110020#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4c77c9c5_5538_47bb_8956_8c82f6f4da2c
boundary condition: true
name: ACSM1
is: Q08AH1
constant: false
type: Species
is encoded by: hsa:116285
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR HSPGtly
kinetic law: MODEL1310110020#
fast: false
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110020#
type: Reaction

metaR r2315
kinetic law: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#

metaM adrn c
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
type: Species
is: CHEBI:53487
is: SBO:0000247
is: HMDB02226
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: adrenic acid

http://identifiers.org/biomodels.db/MODEL1310110020#_15e70195_8dd7_4d64_8d36_619668eaa67f
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q01433
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:271
name: AMPD2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_e3f882c7_92dd_4acf_a41b_57620e246ff5
constant: false
name: MBOAT7
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79143
is: Q96N66
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR S6TASE15ly
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
boundary condition: false
is: C00004
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaM progly e
initial amount: NaN
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB11178
initial concentration: 1.0

metaM Rtotal e
initial concentration: 1.0
name: R total
is: CHEBI:3554
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
is: C00255
type: Species
initial amount: NaN
is: HMDB00244
constant: false
has only substance units: false
boundary condition: false

metaR DDPGAm
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
reversible: true
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000
type: Reaction

metaR MM8Ber
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
fast: false
reactant: MODEL1310110020#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM ksi deg23 l
initial amount: NaN
has only substance units: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 23
type: Species
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00143

metaR AHEXASEly
kinetic law: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110020#

metaM cyan m
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB02084
name: hydrogen cyanide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407

metaM ksi pre34 g
type: Species
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 34
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
constant: false
is: C00130
is: HMDB00175
initial amount: NaN

metaR RDH1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: retinol dehydrogenase (all-trans)
fast: false
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
product: MODEL1310110020#

metaR DHCR71r
modifier: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
kinetic law: MODEL1310110020#
reversible: false
fast: false
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110020#

metaR r1894
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110020#
reversible: false
type: Reaction
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5a1bfb8d_24c0_45eb_bcff_1a0622f18ce4
initial amount: NaN
constant: false
boundary condition: true
name: IVD
is encoded by: hsa:3712
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: B3KVI7

http://identifiers.org/biomodels.db/MODEL1310110020#_b0cb45f9_efd8_4d01_b1c0_0020c10edeb6
has only substance units: false
constant: false
boundary condition: true
name: TKTL1
is encoded by: hsa:8277
type: Species
initial amount: NaN
is: B7Z7I0
initial concentration: NaN
is: SBO:0000252

metaR r2312
is described by: ECO:0000000
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110020#

metaM 4abutn c
initial concentration: 1.0
name: 4-Aminobutanal
type: Species
constant: false
is: HMDB01080
is: SBO:0000247
is: C00555
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b6d567bb_3fef_4c7f_bcb2_75f1f61fdb4b
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:37
is: SBO:0000252
name: ACADVL
boundary condition: true
initial amount: NaN
is: P49748
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b9d448de_2e1f_4c9a_94f9_52a662a61892
initial concentration: NaN
has only substance units: false
name: CROT
is encoded by: hsa:54677
boundary condition: true
is: E7EQF2
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaM lnlncacoa m
constant: false
has only substance units: false
is: CHEBI:51985
boundary condition: false
name: alpha-Linolenoyl-CoA
is: HMDB06290
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
type: Species
is: SBO:0000247
initial amount: NaN

metaR S6TASE9ly
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR PAPtg
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
fast: false
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR r1375
is: SBO:0000185
reactant: MODEL1310110020#
type: Reaction
name: Transport reaction
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f78b8612_8a44_4ef5_8253_ca6a773624ef
boundary condition: true
constant: false
is: SBO:0000252
is: Q96CA6
initial amount: NaN
name: ACAA1
is encoded by: hsa:30
initial concentration: NaN
type: Species
has only substance units: false

metaR UREAt
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
name: Urea transport via facilitate diffusion
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
type: Reaction
fast: false
is: SBO:0000185
reversible: true

metaR COQ5m
type: Reaction
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
name: Ubiquinone biosynthesis methyltransferase COQ5
is described by: ECO:0000000

metaM adrn e
type: Species
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
is: CHEBI:53487
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: adrenic acid

http://identifiers.org/biomodels.db/MODEL1310110020#_6dee1b40_7105_4578_906a_20e041fc372a
initial concentration: NaN
is encoded by: hsa:171425
is: Q8N0X4
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: CLYBL

metaM octdececrn m
has only substance units: false
constant: false
is: HMDB06351
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial concentration: 1.0

metaR FACOAL184
kinetic law: MODEL1310110020#
type: Reaction
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110020#

metaR r2313
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM for c
type: Species
is: C00058
is: CHEBI:15740
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00142
name: Formate
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
initial concentration: 1.0

metaM HC02214 e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: prostaglandin-f1alpha
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
type: Species

metaM progly c
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: HMDB11178
initial concentration: 1.0

metaM Rtotal c
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:16189
initial amount: NaN
boundary condition: false
is: HMDB01448
constant: false
initial concentration: 1.0

metaM dcacoa m
is: C05274
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
boundary condition: false
is: CHEBI:61430

metaM 4abutn e
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
is: SBO:0000247
initial amount: NaN
is: CHEBI:58264
type: Species
is: HMDB01080

http://identifiers.org/biomodels.db/MODEL1310110020#_413ad483_be98_4dbf_a004_795c8479af5e
initial amount: NaN
type: Species
is encoded by: hsa:217
is: SBO:0000252
name: ALDH2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P05091
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1840b26a_b3ac_4100_9a70_a722e0664dd7
is encoded by: hsa:5152
has only substance units: false
boundary condition: true
name: PDE9A
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR SCP21x
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
reversible: true
modifier: MODEL1310110020#
name: Sterol carrier protein 2
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_ed1d8635_545d_47b8_9907_3b2c13abbe7f
initial concentration: NaN
is encoded by: hsa:2876
is: P07203
is: SBO:0000252
type: Species
constant: false
name: GPX1
has only substance units: false
boundary condition: true
initial amount: NaN

metaR GALASE5ly
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110020#_e84b8844_5fe7_4f76_b388_431af505d287
initial concentration: NaN
type: Species
name: ACSL3
initial amount: NaN
is: B3KMA6
is encoded by: hsa:2181
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR C162ACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_649de796_2e28_41de_8c03_f24e09b15147
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5373
initial amount: NaN
name: PMM2
is: SBO:0000252
initial concentration: NaN
is: O15305
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_e58935d1_1292_4cdd_8ad7_db49140bcb29
type: Species
constant: false
initial amount: NaN
is: O00767
is encoded by: hsa:6319
has only substance units: false
initial concentration: NaN
name: SCD
is: SBO:0000252
boundary condition: true

metaR r1650
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
is: SBO:0000185

metaM tridcoa m
is: HMDB13109
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
boundary condition: false
name: tridecanoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
type: Species
is: HMDB01373
constant: false
is: C00882
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57328
is: SBO:0000247
boundary condition: false
name: Dephospho-CoA

metaM CE5101 m
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR BCDO
name: beta-Carotene dioxygenase
is version of: http://identifiers.org/ec-code/1.14.99.36
reversible: false
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000269

metaM 35cgmp e
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746
name: 3',5'-cyclic GMP(1-)
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01314
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3fe00d21_9716_477d_acd8_6215ad7d7eaf
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:271
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: E9PNG0
name: AMPD2

metaR r2310
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_52a4498c_382c_4241_aaaf_45f07eec4f32
type: Species
name: SORD
constant: false
has only substance units: false
is: Q00796
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6652
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_48e60720_108f_44bb_a1c4_1363acb7a89d
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9NX14
is encoded by: hsa:54539
is: SBO:0000252
name: NDUFB11
constant: false
type: Species
initial concentration: NaN

metaM h2o2 e
is: SBO:0000247
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
initial concentration: 1.0
is: CHEBI:16240
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
reversible: true

metaM hdca c
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
constant: false
is: CHEBI:7896
is: HMDB00220
name: palmitate

metaM ksi pre8 g
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
constant: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 8

metaM glcur c
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
constant: false
is: CHEBI:15748
has only substance units: false
name: D-glucuronate
initial concentration: 1.0

metaM 4ppan c
is: CHEBI:10986
name: D-4'-Phosphopantothenate
type: Species
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
is: HMDB01016
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C03492

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR RE2973C
type: Reaction
name: RE2973
modifier: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154

metaR CRNtx
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM acgam1p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
is: HMDB01367
boundary condition: false
is: SBO:0000247
is: CHEBI:7125
constant: false
name: N-Acetyl-D-glucosamine 1-phosphate
type: Species
has only substance units: false
initial concentration: 1.0

metaM C05957 r
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:27485
has only substance units: false
name: Prostaglandin J2
type: Species
initial concentration: 1.0
is: HMDB02710

metaR EX limnen LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Limonene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2c1dd1c6_23db_4619_9531_ff8693b4c3e6
type: Species
name: SLC6A2
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6530
is: Q96KH8

metaR LNLNCACRNt
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
fast: false
reactant: MODEL1310110020#
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM 10fthf c
initial amount: NaN
is: CHEBI:57454
is: C00234
is: SBO:0000247
boundary condition: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
has only substance units: false
is: HMDB00972
type: Species
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM L2aadp m
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: L-2-aminoadipate(1-)
is: CHEBI:58672
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
is: HMDB00510

http://identifiers.org/biomodels.db/MODEL1310110020#_97c69aca_3ffa_4a72_82e8_d7ae119ab6ef
has only substance units: false
is encoded by: hsa:5322
is: P39877
constant: false
name: PLA2G5
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_aea117ee_e295_40e2_8fa6_57a9f2fb4274
type: Species
boundary condition: true
is encoded by: hsa:516
initial concentration: NaN
is: SBO:0000297
has part: Q6FIH7
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false
constant: false

metaM HC02207 e
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
is: CHEBI:27555
initial amount: NaN
type: Species
has only substance units: false
name: prostaglandin-c2

http://identifiers.org/biomodels.db/MODEL1310110020#_4d895890_05ed_456c_9087_32a4fb2bffd3
is encoded by: hsa:8706
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: B3GALNT1
has only substance units: false
is: SBO:0000252
type: Species
is: B3KTQ4

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
initial concentration: 1.0
is: HMDB00142
is: SBO:0000247
has only substance units: false
constant: false
name: formate
type: Species
is: CHEBI:15740
boundary condition: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_6bdfc0e2_cae5_4af3_bdb4_4f84e71bdb1b
is encoded by: hsa:2109
is: SBO:0000297
has part: P13804
is encoded by: hsa:2108
type: Species
initial concentration: NaN
has only substance units: false
name: ETFA:ETFB
boundary condition: true
constant: false
initial amount: NaN

metaR COt
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: CO transporter via diffusion
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
fast: false
is described by: ECO:0000000

metaR GLU5Km
reversible: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000254
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.41
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
fast: false
type: Reaction
name: glutamate 5-kinase (m)

metaR FAOXC163Gm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR FATP2t
reactant: MODEL1310110020#
reversible: true
is: SBO:0000185
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
type: Reaction

metaM lanost r
name: lanosterol
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16521
is: HMDB01251
boundary condition: false
has only substance units: false

metaR AG13T4g
kinetic law: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110020#
reversible: false
is: SBO:0000176
product: MODEL1310110020#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#

metaM 3php c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: HMDB01024
boundary condition: false
type: Species
name: 3-phosphonatooxypyruvate(3-)
constant: false
is: CHEBI:18110
initial amount: NaN
initial concentration: 1.0

metaR ACOAD9m
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
product: MODEL1310110020#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110020#
is: SBO:0000176

metaM CE5132 c
initial concentration: 1.0
constant: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
is: CHEBI:57923
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM dpcoa c
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: HMDB01373
is: C00882
constant: false
initial concentration: 1.0
name: Dephospho-CoA
is: CHEBI:57328
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaM psyl e
boundary condition: false
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
initial amount: NaN
constant: false
name: psyllium
type: Species
initial concentration: 1.0
is: HMDB11178
is: SBO:0000247
has only substance units: false

metaR DMHPTCRNCPT2
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
product: MODEL1310110020#
is: SBO:0000176
name: 2,6 dimethylheptanoly CoA carnitine transferase
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_eada9664_5281_4d42_b03a_e34839d114c4
has only substance units: false
initial concentration: NaN
name: HNMT
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3176
constant: false
is: P50135
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_51a57e61_3135_42b2_a150_4b11addc4332
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6539
type: Species
is: SBO:0000252
is: P48065
constant: false
name: SLC6A12

metaM hdca e
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00249
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
boundary condition: false
is: CHEBI:0
is: HMDB00220
name: Hexadecanoate (n-C16:0)
has only substance units: false

metaM glcur e
initial concentration: 1.0
constant: false
is: CHEBI:15748
is: HMDB00127
has only substance units: false
is: SBO:0000247
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
initial amount: NaN
boundary condition: false

metaM h2o2 c
is: C00027
is: CHEBI:16240
is: HMDB03125
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Hydrogen peroxide
constant: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
initial amount: NaN

metaM trdox c
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
boundary condition: false
initial amount: NaN
is: C00343
type: Species
name: Oxidized thioredoxin
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_3216f1fe_4e66_456b_b894_83c2eb912630
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC2A3
is: P11169
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6515

metaM HC02207 c
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27555
has only substance units: false
initial amount: NaN
type: Species
name: prostaglandin-c2

metaR M7MASNBterg
type: Reaction
fast: false
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110020#
is described by: ECO:0000000
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
kinetic law: MODEL1310110020#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_241c30b9_0f2a_405e_8406_6e102eaf1150
has part: P23921
name: RRM1:RRM2
has part: P31350
constant: false
type: Species
is encoded by: hsa:6241
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6240

metaM 10fthf e
is: CHEBI:57454
is: SBO:0000247
boundary condition: false
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_d90685b3_3ca8_4c4d_a33d_ee7ba990d814
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5009
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: OTC
is: P00480

metaR BACCL
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: biotin-[acetyl-CoA-carboxylase] ligase
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM dtdp m
boundary condition: false
is: HMDB01274
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: CHEBI:58369
is: C00363
type: Species
is: SBO:0000247
name: dTDP
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8ed6c57d_0ea6_4989_9f29_9512720ef90e
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ACAA2
constant: false
has only substance units: false
type: Species
is: P42765
is encoded by: hsa:10449
initial amount: NaN

metaR IDOAASE1ly
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000176

metaR ADNCYC
is described by: ECO:0000269
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/4.6.1.1
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
name: adenylate cyclase
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reversible: false
modifier: MODEL1310110020#

metaR PAPStg
fast: false
reactant: MODEL1310110020#
name: 3'-Phosphoadenylyl sufate Golgi transport
product: MODEL1310110020#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#

metaR FAS80COA L
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reversible: false
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_69df4024_5c0f_4be6_bffb_0bb8c8d3d4e3
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:100128062
name: _100128062_1_m
is: SBO:0000252
has only substance units: false

metaR r0276
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110020#_c66a037b_e0b5_41b2_810f_59e63f4fb1f6
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8398
is: A8K460
constant: false
name: PLA2G6
has only substance units: false

metaM bilglcur c
initial amount: NaN
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
initial concentration: 1.0
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
is: SBO:0000247
has only substance units: false

metaR FAOXC7C5m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR KYNATESYN
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR SFGTH
modifier: MODEL1310110020#
name: S-Formylglutathione hydralase
fast: false
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.12
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110020#

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaM phytcoa x
initial amount: NaN
is: HMDB01359
is: SBO:0000247
name: phytanoyl-CoA(4-)
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
has only substance units: false

metaM dtdp n
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
name: lipid, flip-flop intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_566f6bff_0c09_4249_bd1c_011d2eb1e72b
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:LOC728997
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _LOC728997_1_c

metaM retinal cis 9 c
name: all-trans-retinal
initial concentration: 1.0
has only substance units: false
is: CHEBI:17898
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01358
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7a5ae5a6_e449_4012_8058_4faf5627fac7
constant: false
type: Species
boundary condition: true
is: Q9Y633
is: SBO:0000252
is encoded by: hsa:5136
name: PDE1A
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2395ba2a_6626_45f7_ad19_68264c200a8d
constant: false
name: PANK2
initial amount: NaN
type: Species
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q6P1K9
is: SBO:0000252

metaM phyt x
boundary condition: false
is: CHEBI:37257
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
is: HMDB00801
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_4647d0c8_8d12_4ee2_bac7_2bb2b9f9f75d
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC34A1
is encoded by: hsa:6569
is: Q7Z725
constant: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM acmanap c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB01121
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
name: N-acetyl-D-mannosamine 6-phosphate(2-)
boundary condition: false
has only substance units: false
is: CHEBI:58557
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_8e0d842d_2ec5_4ff6_9981_e51968b3ba0b
is: Q99519
name: NEU1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:4758
constant: false

metaR MI14Ptn
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM glcur r
has only substance units: false
name: D-glucuronate
type: Species
is: CHEBI:15748
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaM trp L c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:16828
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-tryptophan
is: HMDB00929
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

http://identifiers.org/biomodels.db/MODEL1310110020#_9ab7bf0d_fad6_4b99_8778_71ed102a71e9
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P31350
name: RRM2
is encoded by: hsa:6241
constant: false

metaR GLCNACASE5ly
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR SUCCOAPET
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM bilglcur e
has only substance units: false
boundary condition: false
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
is: SBO:0000247
initial amount: NaN

metaR DCYTDn
is described by: ECO:0000254
is: SBO:0000176
name: deoxycytidine deaminase, nuclear
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6fc5549c_e8e9_45f3_a581_cdfedce640d8
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2271
name: FH
is: SBO:0000252
initial concentration: NaN
is: P07954
type: Species
constant: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_11c336ec_a550_4352_aa68_97daf856761b
is encoded by: hsa:10654
initial concentration: NaN
name: PMVK
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q6FGV9
boundary condition: true

metaM CE5132 n
type: Species
initial concentration: 1.0
is: CHEBI:57923
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

http://identifiers.org/biomodels.db/MODEL1310110020#_6f58e53b_353e_4cee_925a_9cd0f43f122a
has only substance units: false
name: ACAD8
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q6ZWP6
is: SBO:0000252
is encoded by: hsa:27034

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
type: Reaction
product: MODEL1310110020#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_6f5d24e8_21fc_4e14_b28d_d5a03bdab06e
is: Q9NS82
initial concentration: NaN
type: Species
is encoded by: hsa:56301
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC7A10
constant: false
is: SBO:0000252

metaR PHEACGLNt
is: SBO:0000185
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
product: MODEL1310110020#
fast: false

metaM strdnccoa c
has only substance units: false
type: Species
is: C16163
initial amount: NaN
name: stearidonyl coenzyme A
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1

metaM tetpent6coa c
is: C16172
is: SBO:0000247
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1

metaM gal1p c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58336
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00645

http://identifiers.org/biomodels.db/MODEL1310110020#_468564f5_65e9_4729_96ff_3400498ff537
is: SBO:0000252
type: Species
is: Q86TM7
name: DPM3
is encoded by: hsa:54344
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR HISDC
notes: GENE_ASSOCIATION: (1644.1) or (3067.1) SUBSYSTEM: Histidine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:14466899 NOTES:IF
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.1.22
name: histidine decarboxylase
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0

metaM dlnlcgcoa m
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
is: CHEBI:27979
constant: false
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM ksi deg16 l
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN
type: Species
is: HMDB00812
name: keratan sulfate I, degradation product 16
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_ce2b5341_7afa_4b0f_9fc3_6239823158fb
constant: false
has part: P23378
is encoded by: hsa:275
has part: P48728
initial amount: NaN
name: DLD:GCSH:GLDC:AMT
is: SBO:0000297
type: Species
boundary condition: true
is encoded by: hsa:2731
has only substance units: false
initial concentration: NaN
has part: P23434
is encoded by: hsa:2653

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
modifier: MODEL1310110020#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: K+-Cl- cotransporter (NH4+)
type: Reaction

metaR SUCCt2m
product: MODEL1310110020#
is: SBO:0000185
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: succinate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
type: Reaction
fast: false

metaM lgt S c
is: CHEBI:57474
type: Species
has only substance units: false
is: HMDB01066
name: (R)-S-lactoylglutathionate(1-)
is: SBO:0000247
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR RE0689E
fast: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
modifier: MODEL1310110020#
reversible: false
is described by: ECO:0000000
name: RE0689
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a4f014bc_9e55_4c4d_9396_30d6767b3174
type: Species
is encoded by: hsa:3295
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: HSD17B4
has only substance units: false
constant: false
is: E9PB82
initial concentration: NaN

metaM glcur l
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:15748
name: D-glucuronate
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
boundary condition: false
has only substance units: false
is: HMDB00127

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
initial amount: NaN
is: HMDB01139
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57404
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247

metaR ALAGLYexR
product: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
name: L-alanine/glycine reversible exchange
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110020#_3ddc93d7_ca75_498d_8bbe_e31c1372611e
is: Q86YI5
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: DLAT
constant: false
is encoded by: hsa:1737

http://identifiers.org/biomodels.db/MODEL1310110020#_e1ebf4a5_da79_408b_a03c_7bcd97d0a7c5
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: ESCO1
type: Species
is: Q5FWF5
is encoded by: hsa:114799
initial concentration: NaN

metaM trdox m
boundary condition: false
has only substance units: false
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
name: Oxidized thioredoxin
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM adrncrn c
is: CHEBI:16347
notes: FORMULA: C29H49NO4 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
name: Adrenyl carnitine
is: C00318
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00062
initial amount: NaN

metaM lneldc e
has only substance units: false
is: SBO:0000247
constant: false
name: linoelaidic acid (all trans C18:2)
initial amount: NaN
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
is: HMDB06270
boundary condition: false

metaM fad c
is: SBO:0000247
is: HMDB01248
is: C00016
boundary condition: false
initial concentration: 1.0
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110020#_8d4685bf_eaf4_4378_ba7a_041a8b66743d
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6576
is: D9HTE9
constant: false
name: SLC25A1
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_70451680_3169_4f80_a1db_5eedc16eab1b
is encoded by: hsa:6548
constant: false
name: SLC9A1
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P19634
initial concentration: NaN

metaM HC01410 m
name: (2E)-Hexenoyl-CoA
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28706
type: Species
boundary condition: false

metaM 4hexdtetcoa m
is: HMDB02288
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
name: 4,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7585a272_a274_4925_8b71_3d9d5291b8a9
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: P46459
is: SBO:0000252
name: NSF
initial amount: NaN
is encoded by: hsa:4905
boundary condition: true

metaR PI3P3Pn
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
type: Reaction
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
reversible: false

metaR EICOSTETt
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110020#
fast: false
reversible: true
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: fatty acid transport via diffusion
is: SBO:0000185

metaM C05965 e
is: SBO:0000247
name: 12(S)-HPETE(1-)
is: HMDB04243
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaM dhlpro m
boundary condition: false
is: CHEBI:16194
name: Dihydrolipolprotein
constant: false
initial concentration: 1.0
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_a68fd370_5cd3_46a3_983c_4cf635e3ffc6
initial amount: NaN
initial concentration: NaN
name: SLC20A1
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6574
is: Q8WUM9
is: SBO:0000252

metaR GLNALANaEx
modifier: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
fast: false
reversible: false

metaM HC02217 e
is: CHEBI:27647
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: prostaglandin-g2
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR HPACtr
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
name: hydroxyphenylacetate transport via diffusion
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000000

metaM T4hcinnm m
is: HMDB02035
is: CHEBI:12876
type: Species
constant: false
initial concentration: 1.0
name: trans-4-coumarate
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR 3SALATAim
is described by: ECO:0000304
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110020#
reversible: false
product: MODEL1310110020#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_a7b65b45_a2a6_47a6_9628_b4a6f42fa705
initial concentration: NaN
name: PLCZ1
is: Q86YW0
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:89869

metaR FAOXC164C143x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaM lnlncacoa c
constant: false
type: Species
is: HMDB06290
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: SBO:0000247
name: alpha-Linolenoyl-CoA
boundary condition: false
initial concentration: 1.0
is: CHEBI:51985
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_ae30884a_757e_49db_8c63_a5ffcc83541d
initial amount: NaN
is encoded by: hsa:771
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O43570
is: SBO:0000252
name: CA12

metaR r1377
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
type: Reaction
product: MODEL1310110020#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110020#

metaM CE2433 m
is: SBO:0000247
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_9956f353_acd9_4731_b25c_8a6bb3a7fd3c
is encoded by: hsa:4967
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q02218
boundary condition: true
initial amount: NaN
name: OGDH
has only substance units: false

metaR RE1527M
reversible: true
name: RE1527
is described by: ECO:0000000
modifier: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM nadh c
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
constant: false
type: Species
initial concentration: 1.0
is: C00004
is: HMDB01487
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306

metaR ACP1 FMN
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
name: acid phosphatase (FMN)
modifier: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
fast: false

metaR NDP7ex
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
name: nucleoside-diphosphatase (UDP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110020#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaM fad e
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
is: HMDB01248
is: C00016
is: CHEBI:16238
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3f6b1dad_6d53_4d3d_9181_0766ccba0e92
boundary condition: true
is encoded by: hsa:8527
constant: false
is: SBO:0000252
initial concentration: NaN
name: DGKD
initial amount: NaN
has only substance units: false
type: Species

metaM lneldc c
type: Species
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
boundary condition: false
is: HMDB06270
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: linoelaidic acid (all trans C18:2)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_4441a88f_d437_4739_b13c_4abb9c9ed43c
is: SBO:0000252
has only substance units: false
is: F5H066
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6560
name: SLC12A4
boundary condition: true
initial amount: NaN

metaR TDCHOLAte
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: bile acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaR DTDPtn
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: dTDP nuclear transport
fast: false
type: Reaction

metaM mescoa m
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Mesaconyl-CoA
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
initial amount: NaN
is: CHEBI:27969
type: Species
is: C06028

metaR LACZe
reversible: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.2.1.108
name: b-galactosidase, extracellular
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176

metaR r0129
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
type: Reaction

metaR r1378
product: MODEL1310110020#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_b43b1ef0_4da8_406f_8be3_7b1f6095a116
name: CA12
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:771
initial amount: NaN

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
initial concentration: 1.0
is: CHEBI:27647
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: prostaglandin-g2
constant: false

metaR ALAASNNaEx
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110020#
product: MODEL1310110020#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
reversible: false

metaM arachcoa x
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB04258
is: CHEBI:15527
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
constant: false
name: arachidyl coenzyme A
initial amount: NaN

metaR CAATPS
modifier: MODEL1310110020#
name: Ca ATPase
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.3.8
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b2d7aae2_a60c_43de_9662_6ad9dfe9915d
has only substance units: false
type: Species
is encoded by: hsa:AI291895
is: SBO:0000252
name: _AI291895_1_c
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cfc01ea9_fbad_4289_adf7_0ff890132132
constant: false
is encoded by: hsa:55350
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: VNN3
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_3ba62983_66ac_48e9_835b_706cc8cae33b
is: SBO:0000252
is encoded by: hsa:251
is: P10696
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: ALPPL2
constant: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a0dfdf97_3265_41b9_be8c_c3eae291b3ee
name: INPP4A
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3631
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b2e5f90a_eba6_4fbf_be67_3bec3599209e
has only substance units: false
boundary condition: true
constant: false
is: O14521
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6392
name: SDHD

metaM dece3coa m
initial amount: NaN
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185

metaR RE1447N
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
name: RE1447
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_e62fe5b7_a31d_4513_a038_555eb978e9d7
type: Species
is encoded by: hsa:27010
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: F5GZG6
name: TPK1
has only substance units: false
initial amount: NaN

metaM arachcoa m
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:15527
is: SBO:0000247
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
has only substance units: false
is: HMDB04258
name: arachidyl coenzyme A

metaM gumtchol e
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: guar gum-taurocholic acid complex

http://identifiers.org/biomodels.db/MODEL1310110020#_22d74a98_7e99_4bfb_b072_a972ac117eb1
initial concentration: NaN
is: P13866
boundary condition: true
name: SLC5A1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6523
has only substance units: false
type: Species
constant: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r0393
modifier: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
reversible: false
product: MODEL1310110020#
type: Reaction

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
initial concentration: 1.0
is: HMDB01052
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28259
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d121f27d_e6b9_4b63_adb0_3c65c528d4aa
is encoded by: hsa:5313
is: P30613
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: PKLR
has only substance units: false

metaR r0122
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110020#
type: Reaction

metaM no e
initial amount: NaN
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
is: SBO:0000247
constant: false
is: C00533
has only substance units: false
is: CHEBI:16480
boundary condition: false
is: HMDB03378
initial concentration: 1.0

metaM 44mctr r
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01023
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
boundary condition: false
has only substance units: false
is: CHEBI:17813

metaR RE1447M
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
name: RE1447
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_08efc7e9_6e1e_4fc1_9266_81c48990c321
initial concentration: NaN
initial amount: NaN
name: OAT
boundary condition: true
is: P04181
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4942

http://identifiers.org/biomodels.db/MODEL1310110020#_f44c6a39_4fc0_4aac_a473_f78eab2206a0
is: Q70HW3
is encoded by: hsa:115286
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC25A26
has only substance units: false
boundary condition: true
constant: false

metaM pail5p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaM dlnlcgcoa c
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
type: Species
is: CHEBI:27979
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_b8249851_925b_4085_81bd_3bac07530de7
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFA10
is encoded by: hsa:4705
is: O95299
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR URAt
modifier: MODEL1310110020#
type: Reaction
fast: false
name: uracil transport via facilated diffusion
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185

metaR r0392
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_17f2007f_ce74_4966_916a_2e6b01595a3e
type: Species
initial concentration: NaN
name: TAZ
is: SBO:0000252
is: Q16635
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6901
initial amount: NaN

metaM c8crn e
initial amount: NaN
name: octanoyl carnitine
is: SBO:0000247
is: C02838
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB00791

http://identifiers.org/biomodels.db/MODEL1310110020#_f1ce664f_e2ab_4f94_80d2_5b90841e797d
is encoded by: hsa:51604
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: Q969N2
name: PIGT
constant: false
is: SBO:0000252

metaR HS4ly
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110020#
name: heparan-N-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
fast: false

metaM dgtp n
name: dGTP
constant: false
boundary condition: false
is: C00286
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
has only substance units: false
is: HMDB01440
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN

metaM 4hphac e
name: 4-hydroxyphenylacetate
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
initial concentration: 1.0
type: Species
is: HMDB00020
initial amount: NaN
boundary condition: false
is: CHEBI:48999

http://identifiers.org/biomodels.db/MODEL1310110020#_52d8781e_53cd_4e52_bb00_f37b28710a25
initial concentration: NaN
has only substance units: false
constant: false
is: Q9UBK5
type: Species
is encoded by: hsa:10870
name: HCST
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1647
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
fast: false
kinetic law: MODEL1310110020#
type: Reaction

metaR PPAm
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase

metaM prostgf2 e
is: HMDB01139
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
initial amount: NaN
is: CHEBI:57404
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin F2alpha(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_f288ed45_6b00_4eb6_8afb_c5fede8abf60
name: COL4A3BP
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9Y5P4
is: SBO:0000252
type: Species
is encoded by: hsa:10087

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

metaR FAOXC164C143m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR 5MTHFt2le
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110020#_a0dff029_3ad3_429a_a078_053041fc7a4f
is encoded by: hsa:2592
initial concentration: NaN
initial amount: NaN
name: GALT
is: B2RAT6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
constant: false
is: HMDB00972
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57454
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_a9be98af_6480_4715_a55b_095602c73c63
is: SBO:0000252
initial amount: NaN
name: TSTA3
initial concentration: NaN
type: Species
is encoded by: hsa:7264
has only substance units: false
boundary condition: true
is: Q13630
constant: false

metaM no c
has only substance units: false
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
constant: false
boundary condition: false
is: C00533
is: CHEBI:16480
is: HMDB03378
name: Nitric oxide
type: Species
initial concentration: 1.0

metaM HC02187 e
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
name: reverse-triiodthyronine
has only substance units: false

metaM leuktrE4 e
name: leukotriene E4(1-)
is: CHEBI:57462
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02200

metaR r1648
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_ad14dd67_4039_423b_aaa9_80a13a322344
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: NT5C1B
boundary condition: true
type: Species
is encoded by: hsa:93034
constant: false
is: Q96P26

metaR LALDO2x
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
product: MODEL1310110020#
is: SBO:0000176
fast: false
name: D-Lactaldehyde:NAD+ 1-oxidoreductase

metaR RE2973N
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
type: Reaction
name: RE2973
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#

metaR TREHe
is described by: ECO:0000269
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110020#
name: alpha,alpha-trehalase
reactant: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2e81ec7e_4705_49d6_a65a_2e16b7720b82
initial concentration: NaN
initial amount: NaN
is: Q9UNP4
is encoded by: hsa:8869
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ST3GAL5
constant: false
type: Species

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1a87dbbf_9e77_43f9_bde0_0ca56f2dc6fb
is: Q8NCG5
is encoded by: hsa:10164
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: CHST4
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR RE3004M
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
name: RE3004
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110020#

metaM hdca r
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:7896
constant: false
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00249
name: Hexadecanoate (n-C16:0)

http://identifiers.org/biomodels.db/MODEL1310110020#_21451dd1_81ff_4523_845d_5c35245f47b1
is: SBO:0000252
boundary condition: true
name: AK2
is encoded by: hsa:204
initial concentration: NaN
has only substance units: false
is: P54819
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_14dfe2c0_19af_4bf9_83b5_153ff0658698
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: RPN1
has only substance units: false
type: Species
initial concentration: NaN
is: P04843
is encoded by: hsa:6184

metaR NACHEX2ly
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110020#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176

metaM c8dc c
is: HMDB00791
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: suberyl carnitine
is: C02838
has only substance units: false
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
boundary condition: false

metaR NDP7er
fast: false
reversible: false
reactant: MODEL1310110020#
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
product: MODEL1310110020#

metaR FAOXC184C163x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaM 3hdececrn c
type: Species
name: 3-hydroxyhexadecenoylcarnitine
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C23H43NO5 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB02014

metaR DECDICRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR RETFAt
fast: false
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false
name: fatty acid retinol efflux
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185

metaM 4hphac c
name: 4-hydroxyphenylacetate
has only substance units: false
is: CHEBI:48999
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00020

metaM c101crn e
type: Species
constant: false
initial concentration: 1.0
name: decenoyl carnitine
has only substance units: false
initial amount: NaN
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaM trp L e
name: L-tryptophan
is: HMDB00929
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
is: CHEBI:16828

metaR DMHPTCRNte
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
fast: false
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
name: 2,6 dimethylheptanoyl carnitine transport

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
reversible: true
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR FAS140COA
type: Reaction
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C14:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a382ec16_c12c_4f03_a7d4_e34825c1e2a9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:622
is: SBO:0000252
name: BDH1
boundary condition: true
constant: false
is: Q02338
initial amount: NaN
type: Species

metaM adrncrn m
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C29H49NO4 CHARGE: 0
is: CHEBI:16347
is: C00318
initial amount: NaN
boundary condition: false
is: HMDB00062
has only substance units: false
name: Adrenyl carnitine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_10e63940_ad02_41ba_bf62_342b0f17ccff
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9H6Y6
is encoded by: hsa:4645
name: MYO5B

http://identifiers.org/biomodels.db/MODEL1310110020#_c84471fa_f814_4e7f_b610_bc9ab32bfe6a
boundary condition: true
initial amount: NaN
has only substance units: false
name: NME2
type: Species
is encoded by: hsa:4831
is: SBO:0000252
initial concentration: NaN
is: P22392
constant: false

metaM strdnccoa m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB06519
type: Species
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
has only substance units: false
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN

metaM leuktrE4 c
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57462
initial concentration: 1.0
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
type: Species
name: leukotriene E4(1-)
is: HMDB02200
is: SBO:0000247

metaR MANter
name: mannose efflux from endoplasmic reticulum
type: Reaction
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
reversible: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaM dcacoa x
constant: false
initial amount: NaN
is: CHEBI:61430
boundary condition: false
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM mi1p D n
is: SBO:0000247
is: CHEBI:58433
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
initial amount: NaN
boundary condition: false

metaM datp c
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01532
name: dATP
constant: false
initial concentration: 1.0
is: CHEBI:61404
type: Species

metaM apoC Lys c
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: Apocarboxylase (Lys residue)
is: CHEBI:32551
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H13N2OX CHARGE: 0

metaM tettet6coa c
is: SBO:0000247
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: http://identifiers.org/pubchem.compound/47205481
is: C16171
constant: false
type: Species
is: HMDB06516
initial concentration: 1.0
name: tetracosatetraenoyl coenzyme A
boundary condition: false
initial amount: NaN
has only substance units: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_0a7c99c6_a718_45fa_a720_e75e77d859b6
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3939
is encoded by: hsa:3945
has part: P07195
constant: false
name: LDHA:LDHB
has part: P00338
has only substance units: false
is: SBO:0000297
initial amount: NaN

metaR GDPFUCtg
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
fast: false
is described by: ECO:0000269
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
name: GDPFuc Golgi transport via CMP antiport
is: SBO:0000185
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d28a9554_5062_4ccf_b1ed_9b4f6ccbc327
is: SBO:0000252
constant: false
is: P36269
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: GGT5
is encoded by: hsa:2687

http://identifiers.org/biomodels.db/MODEL1310110020#_8fc4ad67_c5bb_4de5_96a1_7cf199526c61
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI345944
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: _AI345944_1_m

metaR TXA2tr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
reactant: MODEL1310110020#
name: thromboxane A2 intracellular transport
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_58dcd0e5_d9a9_4876_bb5b_8e7c5eb1cfdc
has only substance units: false
initial concentration: NaN
is: Q9GZV3
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:60482
is: SBO:0000252
name: SLC5A7
boundary condition: true

metaM udpacgal l
boundary condition: false
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
type: Species
is: HMDB00304
constant: false
has only substance units: false

metaR DURAD2
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110020#
product: MODEL1310110020#
name: dihydrothymin dehydrogenase (NADP)
is described by: ECO:0000269
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110020#
type: Reaction

metaR CYTK12
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000269

metaM 3hdececrn e
has only substance units: false
is: HMDB12930
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxyhexadecenoylcarnitine
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_12c77f52_e40c_482a_9963_c0eef3b298b4
constant: false
name: ACSL3
is: SBO:0000252
is encoded by: hsa:2181
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O95573

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110020#
name: inositol-1,4,5-trisphosphate 5-phosphatase
reversible: false

metaM ahcys m
is: CHEBI:16680
is: HMDB00939
is: SBO:0000247
is: C00021
name: S-Adenosyl-L-homocysteine
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_89c13f1a_80ab_4e41_a1ee_2861e9b8f2fa
initial amount: NaN
name: PIGL
is encoded by: hsa:9487
constant: false
boundary condition: true
has only substance units: false
type: Species
is: Q9Y2B2
initial concentration: NaN
is: SBO:0000252

metaR NACHEX17ly
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110020#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9c5e17e7_0920_498c_914c_80045a275df1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AU149534
constant: false
is: SBO:0000252
name: _AU149534_1_c
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_75d512b9_1d63_4a71_a48d_82fa0bad2ae1
boundary condition: true
is encoded by: hsa:230
name: ALDOC
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: P09972

metaM fad m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16238
initial amount: NaN
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
is: C00016
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c83ef619_37ab_44b4_ac08_13c5d378e846
has only substance units: false
is: SBO:0000252
name: ALDOB
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: P05062
is encoded by: hsa:229

metaM c101crn c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: decenoyl carnitine
has only substance units: false
constant: false
notes: FORMULA: C17H31NO4 CHARGE: 0
initial amount: NaN
is: HMDB13205
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c4e39bb6_0654_42b2_a4b9_81c5569aa283
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:26227
name: PHGDH
has only substance units: false
constant: false
type: Species
is: O43175

http://identifiers.org/biomodels.db/MODEL1310110020#_fd13b018_6980_4566_9b9d_70c9cd898e8a
name: _AI915649_1_c
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI915649
boundary condition: true
constant: false
initial concentration: NaN

metaM 4hexdtetcoa x
is: SBO:0000247
type: Species
name: 4,7,10,13-hexadecatetraenoylcoa
boundary condition: false
constant: false
is: HMDB02288
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_685cadc2_dab8_4c02_b583_271876981139
initial amount: NaN
is encoded by: hsa:4594
constant: false
name: MUT
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P22033
type: Species
has only substance units: false

metaM pheacgln c
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial amount: NaN
is: HMDB06344
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:58310

metaR GTHP
is described by: ECO:0000134
modifier: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
name: glutathione peroxidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110020#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110020#

metaR PRGNLONEtm
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
name: pregnenolone intracellular transport
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaM arachdcoa x
name: arachidonoyl-CoA(4-)
type: Species
initial amount: NaN
is: HMDB06523
is: CHEBI:57368
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_0452da81_b80e_4ed1_9783_1ee21676a7e5
constant: false
name: _AA854479_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA854479
is: SBO:0000252
boundary condition: true
type: Species

metaR r2051
fast: false
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR GUAt
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
name: Guanine transport
modifier: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5061d511_bdef_4e56_b26e_a67469cf8961
name: NDUFV1
is: SBO:0000252
constant: false
is encoded by: hsa:4723
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: E5KNH5
type: Species

metaR SUCCCROT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaM m4mpdol L c
initial amount: NaN
is: CHEBI:37633
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_b535e2eb_526f_4cea_a55a_1134e3877307
boundary condition: true
constant: false
is: P61457
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5092
has only substance units: false
type: Species
name: PCBD1

metaR r0390
reversible: true
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#

metaR CYTK13
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR ATPH1e
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: ATP diphosphohydrolase
modifier: MODEL1310110020#
is described by: ECO:0000269

metaM c8crn c
constant: false
is: HMDB00791
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: C02838
is: SBO:0000247
name: octanoyl carnitine
notes: FORMULA: C15H29NO4 CHARGE: 0

metaM acgbgbside hs l
is: HMDB00215
initial amount: NaN
boundary condition: false
name: beta GalNAc globoside
has only substance units: false
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
is: CHEBI:17411
initial concentration: 1.0
is: SBO:0000247

metaM dhcholoylcoa x
has only substance units: false
is: SBO:0000247
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
constant: false
type: Species
boundary condition: false
is: CHEBI:27393
is: HMDB06895
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_b5c00fb2_0975_4509_9e3b_2a525cf5a800
is encoded by: hsa:2678
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: P19440
has only substance units: false
boundary condition: true
name: GGT1

metaR ACONT
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
name: aconitase
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110020#
type: Reaction
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_e1a558b1_0091_4bc9_b8ca_566b7fe30fef
has only substance units: false
boundary condition: true
initial amount: NaN
name: LCAT
is: P04180
is encoded by: hsa:3931
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR NDPK7n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
kinetic law: MODEL1310110020#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_5e1b366f_ed59_432f_bd2e_13603770e27a
boundary condition: true
has only substance units: false
name: ST8SIA1
type: Species
initial concentration: NaN
is encoded by: hsa:6489
is: SBO:0000252
constant: false
is: Q92185
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_f1daf3bb_ec16_40f8_a76c_173662913ef1
has only substance units: false
constant: false
is encoded by: hsa:D29675
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: _D29675_1_e

metaR FAOXC226C227m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR GGH 10FTHF7GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110020#
product: MODEL1310110020#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176

metaR GMPtg
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
fast: false
name: GMP transport (Golgi)

metaR r1640
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110020#
is: SBO:0000185
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#

metaR PGLer
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110020#
fast: false

metaR SPHMYLNtg
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: sphingomyelin intracellular transport
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000000

metaR 5MTAte
product: MODEL1310110020#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
name: Transport of 5-S-methyl-5-thioadenosine

metaM glyc e
is: HMDB00131
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: Glycerol
initial concentration: 1.0
has only substance units: false
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
is: CHEBI:17754

metaM oaa m
name: Oxaloacetate
type: Species
is: SBO:0000247
is: C00036
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00223
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial concentration: 1.0
is: CHEBI:16452

metaM leuktrA4 e
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01337
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)
is: CHEBI:57463

metaR C18OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaM c10crn e
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C17H33NO4 CHARGE: 0
has only substance units: false
is: HMDB00651
name: decanoyl carnitine

metaM arachcoa c
is: SBO:0000247
is: HMDB04258
initial concentration: 1.0
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species
has only substance units: false
boundary condition: false
name: arachidyl coenzyme A
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_4d5e5cd8_7f69_4983_957c_414f39fe8aca
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:23475
name: QPRT
constant: false
initial concentration: NaN
is: Q15274

metaM udpacgal g
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
constant: false
is: CHEBI:57847
is: SBO:0000247

metaR RE3326M
product: MODEL1310110020#
reversible: true
name: RE3326
modifier: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
reactant: MODEL1310110020#
type: Reaction

metaM hexdiac c
name: hexadecanediocacid
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C08260
has only substance units: false
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
is: SBO:0000247

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
is: HMDB00078
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: L-cysteinylglycine
is: CHEBI:4047

metaM h2o e
initial concentration: 1.0
has only substance units: false
is: C00001
name: H2O
is: CHEBI:15377
is: HMDB02111
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN

metaR SIAASE2ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
name: sialidase, lysosomal
reversible: false
modifier: MODEL1310110020#

metaM ksi deg17 l
name: keratan sulfate I, degradation product 17
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
type: Species
has only substance units: false
is: HMDB00143
is: CHEBI:12936
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_e09977cc_4e5b_459e_98cc_aff8a2935227
is: Q9UKG4
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC13A4
is encoded by: hsa:26266
type: Species
has only substance units: false

metaR N2M2NMASNtly
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: n2m2nmasn transport, extracellular to lysosome
is described by: ECO:0000000
product: MODEL1310110020#
reversible: false
fast: false

metaR AG13T3g
reactant: MODEL1310110020#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_4fa34e36_8af5_4576_8876_1d9c80f224ce
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: SDS
is: P20132
is encoded by: hsa:10993
initial amount: NaN
constant: false

metaM glyc c
is: CHEBI:17754
is: HMDB00131
boundary condition: false
is: SBO:0000247
name: Glycerol
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
is: C00116

metaR r1779
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false

metaR r1642
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR RE0344C
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
name: RE0344
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110020#

metaM arachdcoa m
initial concentration: 1.0
type: Species
is: HMDB06523
boundary condition: false
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
name: arachidonoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57368
has only substance units: false

metaR 4HGLSDm
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: true
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
fast: false
product: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM xu5p D c
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
has only substance units: false
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57737
initial amount: NaN
boundary condition: false

metaR RE0830N
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
fast: false
name: RE0830
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM cs e deg6 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
has only substance units: false
boundary condition: false
is: CHEBI:16953
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00812
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6

metaM o2 e
name: O2
boundary condition: false
has only substance units: false
constant: false
is: HMDB01377
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00007
type: Species

metaR URCN
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
name: URCN
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.49
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_96f440c7_ef0b_44a1_9442_881faa9dc7c0
has only substance units: false
is encoded by: hsa:205
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: AK4
is: P27144
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_5393384a_1b42_4d38_a569_bd9a372fd5e0
initial amount: NaN
is: O43286
boundary condition: true
initial concentration: NaN
name: B4GALT5
is encoded by: hsa:9334
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR TETHEX3t
kinetic law: MODEL1310110020#
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM cs b l
is: CHEBI:36005
boundary condition: false
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB02183
has only substance units: false
is: SBO:0000247

metaM h2o g
is: SBO:0000247
name: water
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
initial amount: NaN
is: CHEBI:15377
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1f2251bc_66e3_4f53_a0bf_98bc73126bbb
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:231
name: AKR1B1
has only substance units: false
is: P15121
type: Species
constant: false
is: SBO:0000252

metaM cgly e
boundary condition: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
is: CHEBI:4047
is: HMDB00078
initial amount: NaN
is: SBO:0000247
name: L-cysteinylglycine
constant: false
has only substance units: false

metaR r1641
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110020#
type: Reaction

metaR r1088
type: Reaction
name: Active transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#

metaM txa2 r
is: HMDB01452
is: CHEBI:57445
is: SBO:0000247
initial concentration: 1.0
type: Species
name: thromboxane A2(1-)
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

http://identifiers.org/biomodels.db/MODEL1310110020#_56450bce_377d_4c84_be12_70cd65bb0448
initial concentration: NaN
name: _AA977580_1_c
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA977580
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_c53ea713_7cdb_49ca_b83a_1febe3a51ec2
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: CHAT
initial concentration: NaN
boundary condition: true
is: P28329
is encoded by: hsa:1103

metaR S6TASE16ly
product: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR AHEXASE2ly
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is: SBO:0000176

metaM g1p c
has only substance units: false
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
is: CHEBI:58601
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00103
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_417eb580_325d_432b_821d_c7cd2e6a0a75
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4830
boundary condition: true
has only substance units: false
type: Species
name: NME1

metaR FAOXC150m
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
name: Beta oxidation of long chain fatty acid (odd chain)
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000269

metaR ASPNATm
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
product: MODEL1310110020#
reactant: MODEL1310110020#
name: aspartate N-acetyltransferase, mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_71d9305f_89cc_484e_9449_017672cacef7
is: SBO:0000252
boundary condition: true
type: Species
name: PPAP2C
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8612
is: E9PAY8
initial concentration: NaN

metaR UDPGLCter
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110020#_3945e9f8_23ac_4889_979a_db651d25aaf2
initial concentration: NaN
name: ATP5J
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:522
constant: false
initial amount: NaN
boundary condition: true

metaR FAOXC226205m
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false
fast: false
modifier: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 10fthf7glu e
boundary condition: false
is: SBO:0000247
is: HMDB00972
notes: FORMULA: C50H57N13O25 CHARGE: -8
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)
is: CHEBI:57454
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR P4501B1r
reactant: MODEL1310110020#
fast: false
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
kinetic law: MODEL1310110020#
name: cytochrome P450 1B1
product: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

metaR ALADGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110020#
fast: false
is: SBO:0000185
name: D-alanine/glycine reversible exchange
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
reversible: true
is described by: ECO:0000304

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
product: MODEL1310110020#
type: Reaction

metaM gdp e
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB01201
has only substance units: false
is: CHEBI:58189

metaM udpacgal c
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00304
constant: false
is: CHEBI:57847
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110020#_1fd5a8e6_b195_4022_8b27_cac8009c7e5b
type: Species
is encoded by: hsa:5297
name: PI4KA
constant: false
boundary condition: true
has only substance units: false
is: B4DYG5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PDE1
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f15196a9_2ff5_43de_99ab_c997f4fa469d
is encoded by: hsa:5092
name: PCBD1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM odecoa r
is: CHEBI:57387
type: Species
is: HMDB01322
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: oleoyl-CoA(4-)
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaM cholcoar r
is: CHEBI:58677
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
has only substance units: false
is: HMDB02178
initial concentration: 1.0
type: Species
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM mn l
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
constant: false
is: HMDB06535
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
initial concentration: 1.0
boundary condition: false

metaM prostgd2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
name: prostaglandin D2(1-)
is: CHEBI:57406
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaR r1643
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYSTHRNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: false
product: MODEL1310110020#

metaR CYSASNNaEx
kinetic law: MODEL1310110020#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
type: Reaction
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110020#_1f049e2a_3f9d_4ca6_99d8_5bd324d91cbc
constant: false
initial amount: NaN
has only substance units: false
name: SLC43A2
is encoded by: hsa:124935
is: SBO:0000252
boundary condition: true
is: Q8N370
type: Species
initial concentration: NaN

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
is: CHEBI:58178
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)

metaR r2329
product: MODEL1310110020#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#

metaM retfa e
is: CHEBI:15963
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00508
name: fatty acid retinol

metaM glyald c
type: Species
is: C00577
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
constant: false
is: CHEBI:17378
name: D-Glyceraldehyde

metaR CTPtn
is: SBO:0000185
reactant: MODEL1310110020#
name: CTP diffusion in nucleus
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_8da1e69e_8da3_4089_9f93_7b55b61d1cf5
is: E9PB82
type: Species
initial concentration: NaN
is encoded by: hsa:3295
initial amount: NaN
constant: false
name: HSD17B4
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM hs deg15 l
is: SBO:0000247
is: HMDB00127
type: Species
constant: false
is: CHEBI:15748
name: heparan sulfate, degradation product 15
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7

metaR PDE4
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
fast: false
modifier: MODEL1310110020#
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: false

metaM dolmanp L r
has only substance units: false
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
type: Species
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM g1p e
is: HMDB01586
is: SBO:0000247
is: CHEBI:58601
boundary condition: false
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103

http://identifiers.org/biomodels.db/MODEL1310110020#_faca2a96_e863_4c04_b56b_bd7c49168fad
is: SBO:0000252
initial amount: NaN
name: _R39999_1_c
constant: false
type: Species
is encoded by: hsa:R39999
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR FAS160COA
reversible: false
product: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C16:0CoA)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
modifier: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c2ade114_06cb_4049_b01d_8d701feadb76
boundary condition: true
name: PSAT1
is: Q9Y617
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:29968

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_96b56d17_9d61_477c_a83c_95a8f11d0fda
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: Q9BY32
initial amount: NaN
is encoded by: hsa:3704
is: SBO:0000252
name: ITPA
has only substance units: false

metaM ctp n
initial amount: NaN
constant: false
is: CHEBI:37563
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
type: Species
is: HMDB00082
name: CTP(4-)

http://identifiers.org/biomodels.db/MODEL1310110020#_53c75898_7c84_4ab7_b60c_878eec9b02a3
type: Species
constant: false
name: GGH
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8836
initial amount: NaN
boundary condition: true
is: Q92820
has only substance units: false

metaR DAGK hs
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR r1646
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_789a165a_b57a_4fd4_8267_28f5e662e090
is: P33402
constant: false
initial amount: NaN
is encoded by: hsa:2977
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: GUCY1A2
is: SBO:0000252

metaM gdp g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
name: GDP(3-)
is: SBO:0000247
constant: false
is: HMDB01201
type: Species
boundary condition: false
is: CHEBI:58189

metaR HSAT4ly
is: SBO:0000185
reversible: false
reactant: MODEL1310110020#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false

metaM h2o l
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: water
is: CHEBI:15377
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110020#_1a84d9c7_0362_4124_b514_397c69f639b5
is encoded by: hsa:2954
initial amount: NaN
initial concentration: NaN
type: Species
name: GSTZ1
boundary condition: true
is: A6NED0
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_0d14b07e_1329_468e_80ee_26edb54fa73a
boundary condition: true
is encoded by: hsa:768
initial concentration: NaN
constant: false
initial amount: NaN
is: Q16790
is: SBO:0000252
name: CA9
type: Species
has only substance units: false

metaR LYSOXp
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110020#_0ca67cec_2c48_4157_877c_09e238fa8f9e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: CBR1
is encoded by: hsa:873
is: P16152

metaM gar c
is: CHEBI:58457
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: N1-(5-Phospho-D-ribosyl)glycinamide
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022
initial concentration: 1.0
is: C03838
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_ecd0989b_6897_4d59_82a1_54a8ff450baf
is encoded by: hsa:55825
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: PECR
is: Q9BY49

metaM leuktrA4 c
type: Species
initial amount: NaN
is: HMDB01337
has only substance units: false
name: leukotriene A4(1-)
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57463
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

http://identifiers.org/biomodels.db/MODEL1310110020#_636f7dac_b836_4fb6_9e93_a8669cfd5069
constant: false
type: Species
boundary condition: true
name: ELOVL6
is encoded by: hsa:79071
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9H5J4

metaM ctp m
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:37563
is: HMDB00082
type: Species
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN

metaR r1645
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR FACOAL170
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR ACRNtm
kinetic law: MODEL1310110020#
name: O-acetylcarnintine transport into mitochondria via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
reversible: false
modifier: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000269

metaM dcmp c
is: HMDB01202
initial concentration: 1.0
name: dCMP
initial amount: NaN
is: CHEBI:57566
has only substance units: false
is: C00239
type: Species
constant: false
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247

metaM retfa c
is: CHEBI:50211
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: HMDB00305
name: fatty acid retinol

metaR r2324
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false

metaM bildglcur c
initial concentration: 1.0
is: HMDB03325
is: SBO:0000247
has only substance units: false
type: Species
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaM betald m
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: betaine aldehyde
is: HMDB01252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a74e3b5f_dcbb_40bd_bc06_e20c4e6f2d24
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110020#_4fd7653d_006c_4580_9971_40da1a62176b
name: GNE
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: B7Z428
is encoded by: hsa:10020
boundary condition: true
initial amount: NaN

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM ksi pre35 g
is: SBO:0000247
is: CHEBI:28067
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
name: keratan sulfate I biosynthesis, precursor 35
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_dd13b733_59ee_4f27_8db6_6d216eb6fe62
is encoded by: hsa:514
is: P56381
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ATP5E
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 3ddcrn e
is: HMDB00791
notes: FORMULA: C19H37NO5 CHARGE: 0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxydodecanoylcarnitine
has only substance units: false
is: C02838

metaM odecoa m
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01322
is: CHEBI:57387
type: Species
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: Octadecenoyl-CoA (n-C18:1CoA)

http://identifiers.org/biomodels.db/MODEL1310110020#_c2ede8a2_6d55_46ef_8c86_f0fd48ef262c
initial amount: NaN
is: P16930
has only substance units: false
is encoded by: hsa:2184
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: FAH
initial concentration: NaN

metaR FUM
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_a0db980c_1d88_4c74_be84_9c812b563b0c
initial concentration: NaN
is encoded by: hsa:5291
has part: B3KT19
initial amount: NaN
has only substance units: false
is: SBO:0000297
is encoded by: hsa:5295
boundary condition: true
has part: B4DER4
type: Species
name: PIK3CB:PIK3R1
constant: false

metaR DNDPt26m
name: dCDP transport via dUDP antiport
fast: false
modifier: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#

metaM datp m
is: HMDB01532
is: CHEBI:61404
is: SBO:0000247
constant: false
initial amount: NaN
is: C00131
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8a8a585a_63f5_41a7_8746_58def5c90527
has only substance units: false
is encoded by: hsa:285973
is: Q674R7
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: ATG9B
initial concentration: NaN
is: SBO:0000252

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR r2325
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM prostgd2 r
initial concentration: 1.0
boundary condition: false
constant: false
name: prostaglandin D2(1-)
is: CHEBI:57406
type: Species
has only substance units: false
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_a85d48e8_214f_4f11_9da1_8975cb5be278
is: B7Z6Q4
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3612
boundary condition: true
name: IMPA1
initial concentration: NaN

metaR XYLUR
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
type: Reaction
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
name: xylulose reductase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.10
fast: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM ksi deg21 l
has only substance units: false
boundary condition: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
name: keratan sulfate I, degradation product 21
is: CHEBI:12936
constant: false
type: Species
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM arachdcoa c
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06523
has only substance units: false
name: arachidonoyl-CoA(4-)
is: CHEBI:57368

metaM cys L e
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17561
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
is: HMDB00574
initial concentration: 1.0

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM bhb e
has only substance units: false
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
type: Species
is: HMDB00011
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_66be456e_3298_4899_bc95_d4005bd0ca82
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: ATP5D
is encoded by: hsa:513

http://identifiers.org/biomodels.db/MODEL1310110020#_07ea1048_627c_4b91_ba9c_c4f650f7a524
has only substance units: false
is: F8W682
initial amount: NaN
is encoded by: hsa:6522
name: SLC4A2
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RE2814M
reversible: true
type: Reaction
is: SBO:0000176
name: RE2814
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
kinetic law: MODEL1310110020#

metaR MDHm
is described by: ECO:0000134
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial
type: Reaction
modifier: MODEL1310110020#

metaM oxa e
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
is: CHEBI:30623
type: Species
initial amount: NaN
initial concentration: 1.0
name: oxalate(2-)
constant: false
is: HMDB02329
has only substance units: false

metaM datp n
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00131
name: dATP
is: HMDB01532
is: CHEBI:61404
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_60891d21_b28d_445b_be4f_401167704000
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ENPP3
is: SBO:0000252
is: Q308M7
is encoded by: hsa:5169

metaR GALt4
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
name: galactose transport via sodium symport
is: SBO:0000185
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#

metaM bildglcur e
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325

metaM uacgam c
is: SBO:0000247
constant: false
is: CHEBI:57705
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
initial amount: NaN
is: HMDB00290
has only substance units: false

metaR r2326
fast: false
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185

metaR PSDm hs
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
type: Reaction
reversible: false
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
name: Phosphatidylserine decarboxylase

http://identifiers.org/biomodels.db/MODEL1310110020#_28eb0281_bd40_4472_8284_078fd4cc1fc9
initial amount: NaN
initial concentration: NaN
type: Species
name: PIK3CA:PIK3R2
is encoded by: hsa:5296
has part: P42336
has only substance units: false
is encoded by: hsa:5290
constant: false
boundary condition: true
has part: O00459
is: SBO:0000297

metaM 4hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: HMDB02288
has only substance units: false
type: Species
name: 4,7,10-hexadecatrienoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM oaa c
is: C00036
is: HMDB00223
constant: false
name: Oxaloacetate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
boundary condition: false
has only substance units: false
type: Species

metaR TMNDNCt
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110020#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_7f32f34d_7e6c_47a9_af79_27cf0285b5b6
is encoded by: hsa:7360
boundary condition: true
initial amount: NaN
has only substance units: false
name: UGP2
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR HPDCACRNt
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
modifier: MODEL1310110020#
name: heptadecanoate transport into the mitochondria
fast: false

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR COQ6m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
name: Ubiquinone biosynthesis monooxgenase COQ6
is: SBO:0000176
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
reactant: MODEL1310110020#
modifier: MODEL1310110020#

metaM glu5sa m
is: SBO:0000247
is: C01165
boundary condition: false
is: CHEBI:17232
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
constant: false
has only substance units: false
is: HMDB02104
initial amount: NaN
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0

metaR 3MOPte
product: MODEL1310110020#
name: Transport of 3-methyl-2-oxopentanoate
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_535a6bb7_cd08_4e82_8bfe_3615bcde41a5
constant: false
has only substance units: false
is: P07686
is encoded by: hsa:3074
name: HEXB
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaM bhb c
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00011
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_bf6fde6b_06ef_4058_90d5_2e57cb063c05
type: Species
initial concentration: NaN
name: PYCR1
boundary condition: true
has only substance units: false
is: A6NFM2
initial amount: NaN
is encoded by: hsa:5831
constant: false
is: SBO:0000252

metaM gdpmann c
has only substance units: false
is: SBO:0000247
is: HMDB01163
initial concentration: 1.0
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
name: GDP-alpha-D-mannose(2-)
constant: false
is: CHEBI:57527
boundary condition: false
initial amount: NaN

metaR r1384
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110020#
is: SBO:0000176
reversible: true
type: Reaction

metaM o2 m
boundary condition: false
is: HMDB01377
name: O2
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
constant: false
is: C00007
is: CHEBI:15379
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_32a7c22f_6bda_48b7_a13d_3a835258e901
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P50747
is: SBO:0000252
is encoded by: hsa:3141
name: HLCS

http://identifiers.org/biomodels.db/MODEL1310110020#_eae47422_3ed0_4c51_8bcc_5b8064c17aa7
initial amount: NaN
constant: false
name: NDUFB8
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4714
is: O95169
boundary condition: true

metaM cys L c
is: SBO:0000247
is: HMDB00574
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
is: CHEBI:17561
boundary condition: false
initial concentration: 1.0
constant: false

metaR MANtg
product: MODEL1310110020#
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#
type: Reaction
name: mannose efflux from Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110020#_1a7629f0_6d5e_45cb_b67d_8a050a37ce6e
initial concentration: NaN
is encoded by: hsa:51205
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACP6
type: Species
is: Q9NPH0
constant: false
is: SBO:0000252

metaM gdp m
boundary condition: false
initial amount: NaN
type: Species
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
constant: false
has only substance units: false
is: CHEBI:58189
initial concentration: 1.0
is: C00035
is: SBO:0000247

metaR PPCDC
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110020#
reversible: false
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM m2gacpail hs r
constant: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16038
type: Species
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
has only substance units: false

metaR RE0452M
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
fast: false
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: RE0452
reversible: true

metaR RE0830C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
is: SBO:0000176
name: RE0830
reversible: true
type: Reaction

metaR r2320
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#

metaR LPCHOLt
is: SBO:0000185
type: Reaction
name: lysophosphatidylcholine transport
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_e17580db_3bd4_479f_857a_38f8dbd9f07b
has only substance units: false
name: _AL038231_1_c
is encoded by: hsa:AL038231
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_1e462b4c_469c_4e11_9fe2_501472e5585b
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84693
initial concentration: NaN
boundary condition: true
name: MCEE
has only substance units: false
constant: false
is: Q96PE7
type: Species

metaR ASNS1
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.3.5.4
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
fast: false
is described by: ECO:0000269
name: asparagine synthase (glutamine-hydrolysing)
reversible: false

metaM dcmp n
is: CHEBI:57566
is: HMDB01202
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
name: dCMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8e6e10d6_914a_4314_b1ca_5c44b060fea8
is encoded by: hsa:765
is: Q5FC00
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: CA6
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM o2 r
initial amount: NaN
type: Species
is: CHEBI:15379
boundary condition: false
constant: false
is: HMDB01377
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_40c65cc6_032d_403d_b77c_7c64333effa7
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: _AI935189_1_m
is encoded by: hsa:AI935189
boundary condition: true
has only substance units: false

metaM gdp n
name: GDP(3-)
is: SBO:0000247
is: HMDB01201
is: CHEBI:58189
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR RE2974C
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.149
name: RE2974
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reversible: true
fast: false
is: SBO:0000176

metaR GLUt2m
name: L-glutamate reversible transport via proton symport, mitochondrial
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR GGH 7DHFe
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_016e1c53_8e4c_4f17_a590_8e01506fe5c3
is: Q7GXZ8
constant: false
initial amount: NaN
is encoded by: hsa:4513
name: COX2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_c32e77be_29aa_485e_af99_52f2a5ae88f2
boundary condition: true
name: CMPK1
constant: false
initial amount: NaN
is: B2R6S5
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:51727
initial concentration: NaN

metaR CERT2gt
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
fast: false
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: ceramide transport protein
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_fd7bff27_82c1_4561_9f09_7643aa752094
initial amount: NaN
boundary condition: true
name: PIK3C2A
is: SBO:0000252
has only substance units: false
is: O00443
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5286

metaR r2321
type: Reaction
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM uacgam g
is: CHEBI:57705
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290

metaM mi34p c
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28858
constant: false
name: 1D-myo-Inositol 3,4-bisphosphate
is: HMDB06235
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063

metaM pyr x
constant: false
is: C00022
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
is: CHEBI:15361
is: HMDB00243
name: pyruvate
initial concentration: 1.0

metaR DHCR72r
is: SBO:0000176
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_58b2049f_a5df_4df9_a695_3adb67d8ccb3
type: Species
name: KYNU
has only substance units: false
is encoded by: hsa:8942
is: SBO:0000252
initial amount: NaN
is: Q16719
boundary condition: true
constant: false
initial concentration: NaN

metaR FATP1t
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
type: Reaction
name: fatty acid electroneutral transport
reactant: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000269

metaR r2322
reversible: true
fast: false
product: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110020#

metaR FUT18g
fast: false
kinetic law: MODEL1310110020#
type: Reaction
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
product: MODEL1310110020#
is described by: ECO:0000269

metaR XYLTt
kinetic law: MODEL1310110020#
is: SBO:0000185
name: Xylitol transport via passive diffusion
reversible: true
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
fast: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR D3AIBTm
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
type: Reaction
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial

metaM ksii core2 deg1 l
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
has only substance units: false
initial amount: NaN
is: HMDB00868
is: CHEBI:57737
constant: false
name: keratan sulfate II (core 2-linked), degradation product 1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_5544d56e_dcde_4864_aeaa_a309f2f8f4d9
has only substance units: false
constant: false
boundary condition: true
is: E7ET30
is encoded by: hsa:50808
type: Species
is: SBO:0000252
initial concentration: NaN
name: AK3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_309309b2_3b96_4dea_adc8_b2246524ddc0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PDE9A

metaM 3ddcrn c
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00623
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H37NO5 CHARGE: 0
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_11517056_986f_43e0_9d3b_173f172a432e
initial concentration: NaN
name: CA4
type: Species
is encoded by: hsa:762
constant: false
is: Q6FHI7
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR URIt5le
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
name: uridine transport in via sodium symport (1:2)
reversible: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_02ddfa2a_e565_4943_ac6d_f60375e8a470
name: RPL36A
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6173
initial concentration: NaN
is: P83881

http://identifiers.org/biomodels.db/MODEL1310110020#_5086d0ea_cc7b_4687_8e33_0d760cbd5757
name: EGFR
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: P00533
boundary condition: true
initial amount: NaN
is encoded by: hsa:1956
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_e3ac3d62_2e98_456c_8430_471bc74467cf
is encoded by: hsa:9123
has only substance units: false
is: O15427
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: SLC16A3
initial concentration: NaN

metaR SUCD1m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
is described by: ECO:0000134
name: succinate dehydrogenase
reactant: MODEL1310110020#

metaR r1381
is: SBO:0000176
type: Reaction
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d00b4b1a_6e85_4316_88eb_2cacfdf39a76
initial amount: NaN
is encoded by: hsa:6547
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: SLC8A3
is: SBO:0000252

metaR CHLtm
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
product: MODEL1310110020#
is: SBO:0000185
fast: false
name: choline transport via diffusion (cytosol to mitochondria)
reversible: true
kinetic law: MODEL1310110020#
type: Reaction

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaM pep m
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Phosphoenolpyruvate
constant: false
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
is: CHEBI:18021
is: C00074

metaR GHMT2rm
fast: false
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.1.2.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

metaM h2o c
has only substance units: false
name: H2O
is: SBO:0000247
is: CHEBI:3303
notes: FORMULA: H2O CHARGE: 0
constant: false
is: HMDB02111
type: Species
initial amount: NaN
is: C00001
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_9bfd7474_8ef7_459f_80af_60f3878c3c2b
boundary condition: true
name: COQ6
constant: false
is: SBO:0000252
type: Species
is: B7Z3K8
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51004

metaR r2323
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM m4mpdol L r
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:37633
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_675d1ffd_0897_4a6f_989d_d56ccfdada7d
name: NDUFS8
initial concentration: NaN
boundary condition: true
is: O00217
is encoded by: hsa:4728
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM oxa c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02329
name: oxalate(2-)
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false

metaR PYDAMK
is: SBO:0000176
is described by: ECO:0000269
name: pyridoxamine kinase
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.35
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
type: Reaction

metaM hexdiac r
is: SBO:0000247
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672
has only substance units: false
is: C08260
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: hexadecanediocacid

metaR r1380
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_0fcb5cb0_69cb_47ef_8659_debdc1c2242f
name: RRM2B
initial concentration: NaN
is: Q7LG56
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:50484
boundary condition: true

metaR BAAT2x
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_3d19831c_bca9_41bb_8239_6fc4781ae6ef
type: Species
boundary condition: true
name: ACOX2
is encoded by: hsa:8309
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: Q99424

metaM txa2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
name: thromboxane A2(1-)
is: CHEBI:57445
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01452
boundary condition: false
type: Species
constant: false

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaM oxa m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
is: CHEBI:30623
has only substance units: false
constant: false
is: HMDB02329
name: oxalate(2-)
type: Species

metaR IDOAASE3ly
type: Reaction
name: alpha-L-iduronidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#

metaR FE3MTP1
modifier: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: transport of ferrous iron into blood
kinetic law: MODEL1310110020#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:

metaR PROt4 2 r
is: SBO:0000185
fast: false
modifier: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_3c30dcc4_96b5_4d19_aa3e_24165d795179
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5287
type: Species
initial amount: NaN
is: SBO:0000252
is: O00750
name: PIK3C2B
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_4694e3f7_271a_447a_9408_ace295959894
initial concentration: NaN
initial amount: NaN
is: P07741
type: Species
has only substance units: false
name: APRT
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:353

metaR FAOXC226205x
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110020#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ksi deg13 l
name: keratan sulfate I, degradation product 13
is: CHEBI:16953
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00812
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
type: Species
boundary condition: false

metaR APOC LYS BTNP
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110020#
fast: false
name: proteolysis of apoC-Lys-btn
product: MODEL1310110020#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a8c6e73d_7186_47b9_ab7d_69ab3f03c65a
name: COX8C
is encoded by: hsa:341947
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q7Z4L0
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_75d0f40c_8fe8_4ff3_b4ad_cb90143bb521
constant: false
has only substance units: false
type: Species
name: SRM
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6723
boundary condition: true
is: P19623

metaM o2 x
is: HMDB01377
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: O2
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial concentration: 1.0
is: C00007
is: SBO:0000247

metaM dgmp c
type: Species
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: C00362
is: HMDB01044
has only substance units: false
name: dGMP
initial amount: NaN

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_8310456b_c95a_4bcd_848c_da3d6e1b4f72
is: SBO:0000252
boundary condition: true
name: INPP5E
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: Q9NRR6
is encoded by: hsa:56623

http://identifiers.org/biomodels.db/MODEL1310110020#_6dc8e180_106b_43af_af93_6785503dd5c1
is: Q308M7
type: Species
is encoded by: hsa:5169
constant: false
is: SBO:0000252
initial amount: NaN
name: ENPP3
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_cd32525b_3a82_4820_af3e_d3553f082bc3
has only substance units: false
name: CHST5
type: Species
is encoded by: hsa:23563
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9GZS9
is: SBO:0000252

metaR C161CRNt
name: C161 transport into the mitochondria
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
reversible: false

metaM caro c
name: beta-carotene
has only substance units: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17579
is: HMDB00561
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_308b290b_b4aa_48ff_92b8_74144d968e7f
is encoded by: hsa:115584
is: Q8WWX8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC5A11
constant: false
has only substance units: false
type: Species

metaR EX 3ivcrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaM glyald m
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: D-glyceraldehyde
is: HMDB01051
is: CHEBI:17378

metaR OCTAt
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Octanoate transport via diffusion
reversible: true
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_87db75c9_3d29_442d_bf07_050070e2ecfc
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q4KWH8
is: SBO:0000252
is encoded by: hsa:23007
has only substance units: false
name: PLCH1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_91c3b64a_c69d_499a_9cf6_c68bfe332334
is: SBO:0000252
boundary condition: true
is: O95864
is encoded by: hsa:9415
initial amount: NaN
name: FADS2
initial concentration: NaN
constant: false
type: Species
has only substance units: false

metaR THFtl
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, lysosomal
is: SBO:0000185
product: MODEL1310110020#

metaM acglcgal14acglcgalgluside hs g
initial amount: NaN
boundary condition: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: CHEBI:17103
constant: false
initial concentration: 1.0
name: nLc5Cer
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_94e34315_d286_40af_871f_b9dfd8207e2f
type: Species
is encoded by: hsa:23236
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: PLCB1
is: SBO:0000252

metaM bilirub r
constant: false
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00054
type: Species
name: bilirubin(2-)
initial concentration: 1.0

metaM 3octdeccrn e
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB13336
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false
is: SBO:0000247
name: 3-hydroxyoctadecanoyl carnitine
constant: false
initial amount: NaN

metaR r0119
reversible: false
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

metaR NACHEX9ly
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#

metaM m7masnB g
has only substance units: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
constant: false
is: SBO:0000247
type: Species
is: C05881
initial concentration: 1.0

metaM g3pc c
is: CHEBI:16870
boundary condition: false
type: Species
initial concentration: 1.0
name: sn-Glycero-3-phosphocholine
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00086
is: SBO:0000247
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670

http://identifiers.org/biomodels.db/MODEL1310110020#_04872402_8a40_4c8f_8c39_61c98955373f
constant: false
is: Q9BT22
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56052
name: ALG1
has only substance units: false
type: Species
is: SBO:0000252

metaR KSIt
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_aad05056_de10_479d_a6bf_f087b647fbeb
is encoded by: hsa:AI971036
name: _AI971036_1_c
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_611d3d83_8e1d_483d_af11_eca33f444fb4
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:79814
is: Q9BSE5
type: Species
name: AGMAT
initial concentration: NaN

metaR THFtm
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
reversible: true

metaR G14T2g
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction

metaR ADPACDAc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaM dgmp e
is: CHEBI:57673
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01044
boundary condition: false
initial amount: NaN
has only substance units: false
name: dGMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_328d7415_aae3_4ccb_92f2_ec8b2b7b3b9c
is: P41222
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5730
initial amount: NaN
name: PTGDS
constant: false
boundary condition: true
initial concentration: NaN

metaR MGCHrm
product: MODEL1310110020#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaM h2o x
is: CHEBI:15377
is: C00001
is: SBO:0000247
constant: false
name: H2O
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110020#_4e1323a7_af18_4bea_b93e_b772d0fa163b
has part: B2RAU6
is: SBO:0000297
is encoded by: hsa:5277
is encoded by: hsa:9091
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
boundary condition: true
has part: P57054
is encoded by: hsa:5279
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_79c9acef_6165_4236_b588_65e970a3cf6c
initial amount: NaN
constant: false
is: Q9UHK6
is: SBO:0000252
name: AMACR
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23600
type: Species
has only substance units: false

metaR MAN6PI
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110020#
name: mannose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_12379201_a5b8_4c69_b39a_a3dad36a785f
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11238
initial amount: NaN
is: Q9Y2D0
name: CA5B
is: SBO:0000252
type: Species
has only substance units: false

metaR MMSAD3m
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
product: MODEL1310110020#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_eb1cb02c_1858_4889_9553_b2d8a9a3d019
type: Species
has only substance units: false
is encoded by: hsa:641649
boundary condition: true
is: SBO:0000252
is: C9JZ62
constant: false
name: TMEM91
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_5c7a7d64_76c1_45c8_b782_16c5c5dc8b6f
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
name: SULT1A1
is encoded by: hsa:6817
initial amount: NaN
initial concentration: NaN

metaM txa2 c
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01452
name: thromboxane A2(1-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_b2f05dad_f876_486a_bea5_403d6994ad91
initial concentration: NaN
constant: false
is: Q53YE7
is encoded by: hsa:4128
type: Species
boundary condition: true
name: MAOA
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM caro e
name: beta-carotene
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00561
is: CHEBI:17579
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
reversible: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: phosphatidylinositol 3-kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110020#
type: Reaction

metaM bhb m
has only substance units: false
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00011
initial concentration: 1.0

metaM 3octdeccrn c
notes: FORMULA: C25H49NO5 CHARGE: 0
initial amount: NaN
boundary condition: false
is: HMDB13336
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxyoctadecanoyl carnitine
constant: false
has only substance units: false

metaR D LACt2
is: SBO:0000185
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
fast: false
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
name: D-lactate transport via proton symport
modifier: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#

metaR CORE3GTg
is described by: ECO:0000000
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
type: Reaction
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false

metaR TYMSULT
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: Tyramine Sulfotransferase

metaM 3otdcoa m
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: HMDB03935
initial concentration: 1.0
constant: false
name: 3-Oxotetradecanoyl-CoA
initial amount: NaN
type: Species
is: CHEBI:28726
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b7c14088_eadd_41c0_a269_39ef71248cbc
name: AMY1A
is: Q6NSB3
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:276

metaR RE0688E
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: false
name: RE0688
fast: false
product: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR CYSSNAT5tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9363bb8f_d27e_4f8d_b501_9111a4c74d2e
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P49753
constant: false
name: ACOT2
is encoded by: hsa:10965

http://identifiers.org/biomodels.db/MODEL1310110020#_f06ca682_8ce1_4055_8f55_7ed045e1eb5d
type: Species
constant: false
is: B3KXY9
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3098
name: HK1

http://identifiers.org/biomodels.db/MODEL1310110020#_19741b4d_7b64_472c_b150_fe010ba2a775
is: Q6ZWP6
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27034
type: Species
name: ACAD8

http://identifiers.org/biomodels.db/MODEL1310110020#_7f4ca42b_ef9b_4f55_bb46_805774c1d8cc
boundary condition: true
name: SI
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6476
initial amount: NaN
initial concentration: NaN
type: Species
is: P14410

metaR C142OHe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaR COQ7m
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
is: SBO:0000176
reversible: false
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
type: Reaction
name: Ubiquinone biosynthesis COQ7
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269

metaM HC02208 e
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: prostaglandin-d1
is: CHEBI:27696
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_df2936d7_efcb_4517_bcee_e4f6f076a723
type: Species
name: PANK1
initial amount: NaN
is: Q8TE04
constant: false
has only substance units: false
is encoded by: hsa:53354
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM 3aib D m
constant: false
initial amount: NaN
type: Species
is: C03265
is: HMDB02299
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0
name: D-3-Amino-isobutanoate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_940f1991_e36b_4482_b474_88ea56242563
has only substance units: false
boundary condition: true
name: BPNT1
is encoded by: hsa:10380
initial amount: NaN
is: SBO:0000252
constant: false
is: O95861
type: Species
initial concentration: NaN

metaR UMPK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: UMP kinase
reversible: true
is: SBO:0000176
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_505b426a_2163_4e33_b3da_bbca3d26c173
has only substance units: false
is encoded by: hsa:230
is: P09972
constant: false
name: ALDOC
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR FAOXC163C143m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaR HSAT1ly
is: SBO:0000185
fast: false
product: MODEL1310110020#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaR P4507A1r
is described by: ECO:0000269
name: cytochrome P450, family 7, subfamily A, polypeptide 1
reversible: false
is: SBO:0000176
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.17

http://identifiers.org/biomodels.db/MODEL1310110020#_883499b9_b3f1_4970_8151_aab66c800497
has only substance units: false
is: P80404
name: ABAT
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:18

metaR GGH 7DHFl
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
product: MODEL1310110020#
is: SBO:0000176
reversible: false
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110020#
type: Reaction

metaR DHPM1
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110020#
name: dihydropyrimidinase (5,6-dihydrouracil)
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_15039484_b22f_4a6c_9ac1_a305db74c2c8
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9H2H9
constant: false
is encoded by: hsa:81539
is: SBO:0000252
name: SLC38A1

metaR RE3568C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction
name: RE3568
is: SBO:0000176
kinetic law: MODEL1310110020#

metaM Ser Gly Ala X Gly l
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB02183
initial concentration: 1.0
name: protein-linked serine residue (glycosaminoglycan attachment site)
notes: FORMULA: XH CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:36005

metaR PIPLC
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110020#
name: phosphatidylinositol phospholipase C
product: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c47d6706_7133_4a68_9060_20f9c02ad735
name: GCK
is encoded by: hsa:2645
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RE1526M
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
name: RE1526

metaM ksi deg38 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 38
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
type: Species

metaR r0268
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
fast: false

metaR 34DHOXPEGt
type: Reaction
fast: false
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
product: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_2ce45cdf_4642_4a08_81bb_8458701816ce
has only substance units: false
constant: false
initial concentration: NaN
name: PIK3C3
is: SBO:0000252
is encoded by: hsa:5289
is: Q8NEB9
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_3032a4f0_311a_47a8_a75e_a6daeb5b9bdf
constant: false
type: Species
name: GRHPR
boundary condition: true
initial amount: NaN
is encoded by: hsa:9380
has only substance units: false
initial concentration: NaN
is: Q9UBQ7
is: SBO:0000252

metaR C142OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_da7ffc80_3b62_47fc_8057_bf849fde4d2f
type: Species
name: DGKA
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: P23743
is: SBO:0000252
is encoded by: hsa:1606

metaR HEXDICOAACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28325

metaR RE2974N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
name: RE2974
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_db48f68e_dc55_4a0b_b9ac_7c1e3a0f9414
constant: false
initial concentration: NaN
boundary condition: true
is: Q75T13
initial amount: NaN
name: PGAP1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80055
type: Species

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM pail3p hs n
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
is: CHEBI:58088

metaR r0267
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM tdec4ecoa m
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: HMDB00792
is: C08277
constant: false
initial amount: NaN
name: trans4decenoylcoa

metaM 4abutn m
is: CHEBI:58264
is: HMDB01080
name: 4-ammoniobutanal
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
initial concentration: 1.0

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR NACHEX1ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_53474352_ef90_4c38_9b55_1d0d2e68327d
initial concentration: NaN
name: PFKFB2
boundary condition: true
is: O60825
type: Species
is encoded by: hsa:5208
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR DRBK
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
name: Deoxyribokinase
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.15
reactant: MODEL1310110020#

metaM h2o m
boundary condition: false
name: H2O
is: HMDB02111
is: C00001
is: CHEBI:15377
type: Species
constant: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM pep c
initial concentration: 1.0
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
type: Species
has only substance units: false
is: C00074
is: HMDB00263
boundary condition: false
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
is: SBO:0000247

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR CYTK9
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r1635
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR SIAT9g
product: MODEL1310110020#
fast: false
type: Reaction
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.9
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
modifier: MODEL1310110020#
is: SBO:0000176

metaR r1994
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110020#
type: Reaction
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_3a3789eb_413a_43b1_9a07_ec0964f97941
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P50993
name: ATP1A2
initial concentration: NaN
is encoded by: hsa:477
type: Species

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110020#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000

metaM glyc m
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00131
name: Glycerol
is: C00116
constant: false
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_a264527b_b54b_4a3f_b1b9_179da6fc1310
is: P27815
is encoded by: hsa:5141
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: PDE4A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_f639aace_db25_4667_8e0f_d6fe2513d379
is encoded by: hsa:23169
boundary condition: true
initial amount: NaN
name: SLC35D1
has only substance units: false
is: SBO:0000252
type: Species
is: Q9NTN3
initial concentration: NaN
constant: false

metaM acgbgbside hs c
initial amount: NaN
has only substance units: false
is: CHEBI:17411
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
initial concentration: 1.0
is: HMDB00215
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: beta GalNAc globoside

metaM h2o n
type: Species
constant: false
name: water
is: HMDB02111
is: SBO:0000247
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR CYTK8
kinetic law: MODEL1310110020#
type: Reaction
fast: false
modifier: MODEL1310110020#
name: cytidylate kinase (CMP,dATP)
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110020#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_b5e36ec9_92f8_4af5_bc34_36ebbf2f2012
has only substance units: false
is encoded by: hsa:9990
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q9UHW9
initial amount: NaN
name: SLC12A6

metaR r1636
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR GALASE19ly
fast: false
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000269
modifier: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM for r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00058
type: Species
is: CHEBI:15740
is: HMDB00142
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate

metaM estradiol c
is: CHEBI:16469
constant: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: estradiol

http://identifiers.org/biomodels.db/MODEL1310110020#_adf5d75e_382f_48b5_9ff7_b8cebc94f691
has only substance units: false
boundary condition: true
is encoded by: hsa:128
initial concentration: NaN
name: ADH5
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6IRT1

metaR ADK3m
type: Reaction
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110020#
fast: false
name: adentylate kinase (GTP)
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
is: SBO:0000176

metaM ctp c
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:37563
is: C00063
boundary condition: false
constant: false
initial concentration: 1.0
name: CTP
is: HMDB00082

http://identifiers.org/biomodels.db/MODEL1310110020#_2217dbda_1f8c_457e_b017_74470e68a155
name: ADSSL1
is encoded by: hsa:122622
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: B3KTV4
initial concentration: NaN

metaM pail3p hs c
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: CHEBI:58088
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR G12MT1 L
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

metaR r1637
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#

metaM ca2 c
is: CHEBI:29108
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
constant: false
name: calcium(2+)
boundary condition: false
is: HMDB00464
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR EX glyleu LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Glycylleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_e407e71e_65b6_4e9e_92a4_f2da9477b267
is: SBO:0000252
boundary condition: true
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR A4GALTg
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110020#
name: Lactosylceramide 4-alpha-galactosyltransferase
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.228
reversible: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f56b5b12_1226_48d0_8edc_9fa299088630
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:114112
is: Q86VQ6
boundary condition: true
name: TXNRD3
initial concentration: NaN
has only substance units: false

metaR 2AMACHYD
is described by: ECO:0000000
name: 2-Aminoacrylate hydrolysis
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is: SBO:0000176
product: MODEL1310110020#
reversible: false
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction

metaR KAS8
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
name: b-ketoacyl synthetase (palmitate, n-C16:0)
reversible: false
reactant: MODEL1310110020#

metaR TOLBUTAMIDEte
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
product: MODEL1310110020#
name: xenobiotic transport
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a2bff198_36a7_4427_8435_857224626cf8
name: PDE1B
is: Q7Z364
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5153
type: Species

metaM pail4p hs c
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58178
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)

metaM 3hpcoa m
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: CHEBI:58528
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_f115fda1_387f_4b3b_9f50_851fd556a334
type: Species
is: Q8IXW6
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: DPYSL3
is encoded by: hsa:1809
has only substance units: false

metaM prostgd2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
name: prostaglandin D2(1-)
has only substance units: false
type: Species
is: CHEBI:57406
is: HMDB01403
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_0b848e27_8882_4d5a_9759_9b4bdc459be8
is: SBO:0000252
constant: false
type: Species
name: AMY2A
is encoded by: hsa:279
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P04746

metaM pyr m
initial concentration: 1.0
is: C00022
is: CHEBI:15361
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
initial amount: NaN
name: pyruvate
is: HMDB00243
type: Species
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324

metaM cholcoar x
is: CHEBI:58677
initial concentration: 1.0
is: HMDB02178
initial amount: NaN
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaR GLYCTDle
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
is: SBO:0000185
reversible: true
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110020#
type: Reaction

metaM hs deg3 l
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 3
is: HMDB00127

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r1638
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR C12OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_dae237f7_d334_489d_b1ae_660687daac59
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DPM2
is: SBO:0000252
is encoded by: hsa:8818
is: O94777
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_b044530a_44f2_4920_bc7b_99b3f4c4d6ad
initial concentration: NaN
boundary condition: true
is encoded by: hsa:175
initial amount: NaN
is: P20933
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: AGA

http://identifiers.org/biomodels.db/MODEL1310110020#_4ce8f0fe_4f48_416a_8040_3d2201430f14
type: Species
is encoded by: hsa:3242
initial concentration: NaN
name: HPD
constant: false
initial amount: NaN
boundary condition: true
is: B3KQ63
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_d3acf836_2a07_4f57_b13d_196e4c5e213d
is: Q1EHB4
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC5A12
type: Species
is encoded by: hsa:159963
initial amount: NaN

metaM Rtotalcoa c
boundary condition: false
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
is: HMDB01448
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM ksi pre15 g
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 15
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
initial concentration: 1.0
is: C00130
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053

metaM ksi pre1 g
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: HMDB00175
is: C00130
type: Species
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false
constant: false
initial concentration: 1.0

metaM tymsf c
has only substance units: false
is: HMDB06409
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
name: Tyramine O-sulfate
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaR ASNSERNaEx
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110020#

metaR IPDPtx
is described by: ECO:0000134
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
product: MODEL1310110020#

metaM HC02208 c
initial amount: NaN
name: prostaglandin-d1
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:27696

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_44e3bb23_6861_41c1_bbaa_21f07ed6efb5
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: CYP2C8
is encoded by: hsa:1558
initial amount: NaN
is: B7Z1F5
boundary condition: true

metaR CYTK5
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_7e1b2c3a_9bc3_4173_9a14_625c9cb701f1
is encoded by: hsa:113
type: Species
initial concentration: NaN
boundary condition: true
name: ADCY7
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P51828

metaM gthox m
is: CHEBI:58297
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
has only substance units: false

metaM ura c
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
has only substance units: false
is: C00106
is: SBO:0000247
name: Uracil
initial concentration: 1.0
is: HMDB00300
boundary condition: false
is: CHEBI:17568
initial amount: NaN
constant: false

metaR ATPH2e
product: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is version of: http://identifiers.org/ec-code/3.6.1.5
name: ATP diphosphohydrolase
is described by: ECO:0000269
reactant: MODEL1310110020#

metaR r1639
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185

metaR TMNDNCCRNt
modifier: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: false
name: transport into the mitochondria (carnitine)
fast: false

metaR PCHOLHSTDe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR LGTHL
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.5
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is described by: ECO:0000269
modifier: MODEL1310110020#
name: lactoylglutathione lyase
product: MODEL1310110020#
reversible: false

metaR RE1254C
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
name: RE1254

metaR CYTK4
reactant: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
type: Reaction
product: MODEL1310110020#
name: cytidylate kinase (dCMP)(GTP)
kinetic law: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false

metaR 1PPDCRp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110020#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

metaM acgbgbside hs g
name: beta GalNAc globoside
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
is: CHEBI:17411
is: HMDB00215
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_26bd039e_60bd_40cf_9dc7_1665d43b9144
constant: false
is: SBO:0000252
is: Q92820
name: GGH
has only substance units: false
boundary condition: true
is encoded by: hsa:8836
type: Species
initial amount: NaN
initial concentration: NaN

metaR UMPK3n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
fast: false
name: UMP kinase (UTP),nuclear
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
product: MODEL1310110020#
modifier: MODEL1310110020#

metaM pac c
name: phenylacetate
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
is: HMDB00209
is: CHEBI:18401
type: Species

metaM h2o r
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
type: Species
is: CHEBI:15377
is: C00001
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02111
name: H2O

metaM tag hs e
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
is: CHEBI:17855
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaM aps c
is: CHEBI:58243
boundary condition: false
is: HMDB01003
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 5'-adenylyl sulfate(2-)
constant: false
initial concentration: 1.0

metaM m5masnB2 g
is: CHEBI:58401
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: SBO:0000247
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB06814
type: Species
initial amount: NaN
initial concentration: 1.0

metaM tymsf e
initial amount: NaN
is: SBO:0000247
is: HMDB06409
has only substance units: false
constant: false
boundary condition: false
name: Tyramine O-sulfate
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
initial concentration: 1.0

metaM ksii core4 pre4 g
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00175
is: C00130
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4

metaM CE0785 m
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: cis,cis-myristo-5,8-dienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
constant: false
is: CHEBI:57795
type: Species
initial concentration: 1.0

metaM tddedi2coa m
initial amount: NaN
boundary condition: false
type: Species
is: C08277
constant: false
is: HMDB00792
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
name: trans2,6dodecadienoylcoa
initial concentration: 1.0

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reversible: true
fast: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
reactant: MODEL1310110020#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR LGNCCOAtx
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
name: fatty acid intracellular transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true

metaM CE2434 m
boundary condition: false
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: CHEBI:57795
type: Species
constant: false

metaR CYTK7
kinetic law: MODEL1310110020#
fast: false
reversible: true
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_978b1766_5cc9_4749_9d63_e3d64d601dff
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5315
is: SBO:0000252
name: PKM2

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM c10crn c
has only substance units: false
name: decanoyl carnitine
notes: FORMULA: C17H33NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: HMDB00651
is: SBO:0000247
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_c202c84a_300a_419a_a66d_d7f48215868b
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: B3GNT8
constant: false
is encoded by: hsa:374907
type: Species

metaM phyt2ohcoa x
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57334
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: HMDB01295
name: 2-hydroxyphytanoyl-CoA(4-)
constant: false
type: Species

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR MALSO3tm
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110020#
is described by: ECO:0000269

metaR EX taxol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: paclitaxel exchange
type: Reaction

metaM estradiol e
name: estradiol
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB00151
initial amount: NaN
is: CHEBI:16469
type: Species
initial concentration: 1.0

metaR CYTK6
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_6bbfdab8_3da7_4a35_86a4_60ce3149b99d
is: SBO:0000252
constant: false
is encoded by: hsa:6542
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: SLC7A2
is: P52569
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_f9fab1d1_4f10_4e8e_980a_3071b09efe71
is: Q8N5Z0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51166
name: AADAT
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_26eeb353_45e2_4e7d_819f_20d502fc1858
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: GALNT10
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:55568

metaR FAOXC142C122m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM tag hs c
name: triglyceride
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:17855
is: SBO:0000247
constant: false
has only substance units: false

metaM m7masnB r
boundary condition: false
initial amount: NaN
is: C05881
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaR LNLCCPT2
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110020#
name: carnitine transferase
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM ksii core2 pre5 g
is: C00130
notes: FORMULA: C61H99N5O43X CHARGE: -1
type: Species
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 5
is: CHEBI:58053
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR RE3003M
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3003
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8

http://identifiers.org/biomodels.db/MODEL1310110020#_87cded9c_bf90_46b0_89a1_f1c4eb5f305b
name: _X63359_1_c
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:X63359
initial amount: NaN

metaR r1090
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c9ff85c5_d4b3_4693_ab6c_3d2c931a0696
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: _AI631997_1_m
is encoded by: hsa:AI631997

http://identifiers.org/biomodels.db/MODEL1310110020#_81156197_2c6e_406b_a558_715775854b16
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4702
is: B1AM93
name: NDUFA8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_308af49b_57e9_4b1f_b50a_357709cb700d
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P42765
is encoded by: hsa:10449
initial concentration: NaN
boundary condition: true
name: ACAA2
initial amount: NaN

metaM ctp e
has only substance units: false
initial concentration: 1.0
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
type: Species
boundary condition: false
is: HMDB00082
is: SBO:0000247
constant: false
initial amount: NaN

metaM 4mtolbutamide c
is: SBO:0000247
type: Species
name: 4 hydroxy tolbutamide
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06408
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)

http://identifiers.org/biomodels.db/MODEL1310110020#_28fa87b0_cec0_4f50_95bd_170355d8fa3e
is: P06132
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:7389
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: UROD

metaR r1634
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM doldp L r
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15750
is: SBO:0000247
name: Dolichol diphosphate, human liver homolog
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
type: Species

metaM ptdcacoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A
constant: false
is: HMDB06499
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM cs a deg4 l
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
initial amount: NaN
is: CHEBI:16953
is: HMDB00812

metaR HPYRRy
modifier: MODEL1310110020#
reversible: false
name: Hydroxypyruvate reductase (NADPH)
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
product: MODEL1310110020#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.79
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3488b918_a9cf_4780_aabd_b8efcc8a3d21
is: SBO:0000252
boundary condition: true
name: ATP2B3
constant: false
is encoded by: hsa:492
initial amount: NaN
has only substance units: false
type: Species
is: Q16720
initial concentration: NaN

metaM glx m
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00119
boundary condition: false
is: CHEBI:36655
name: glyoxylate

metaR CYTK1n
reversible: true
modifier: MODEL1310110020#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#

metaM bilirub e
is: CHEBI:57977
initial amount: NaN
name: bilirubin(2-)
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00054
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR r1633
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#

metaM dolp L r
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: dolichyl phosphate(2-)
is: CHEBI:57683
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_6e0cfbff_504a_40c7_ba3a_adb54aed6452
constant: false
is encoded by: hsa:522
has only substance units: false
has part: P56134
initial amount: NaN
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
is encoded by: hsa:9551
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_dd463bdf_5215_450b_9657_b83eb9278781
initial concentration: NaN
has only substance units: false
type: Species
name: PLA2G1B
initial amount: NaN
is encoded by: hsa:5319
constant: false
is: P04054
boundary condition: true
is: SBO:0000252

metaR FAOXC11C9m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaM cspg e e
is: SBO:0000247
is: HMDB00630
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16040
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_eb188e42_7161_4356_aa3b_db31511fe47d
name: SLC16A8
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:23539
initial concentration: NaN
is: O95907
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM elaidcrn m
boundary condition: false
name: Elaidic carnitine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
type: Species
constant: false
is: HMDB06464

metaM xolest2 hs e
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
initial concentration: 1.0
name: cholesterol ester
is: SBO:0000247
is: CHEBI:17002
boundary condition: false

metaR CYTK1m
fast: false
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
reactant: MODEL1310110020#
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial

metaR r1632
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_632d14bd_1ce5_4479_8b0c_7d41f9d94d2d
is: B4DR31
initial amount: NaN
name: DPYSL2
is encoded by: hsa:1808
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM ser L e
initial amount: NaN
name: L-serine
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00187
boundary condition: false
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR STRDNCCRNt
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
name: transport into the mitochondria (carnitine)
type: Reaction
kinetic law: MODEL1310110020#

metaR DESAT22 1p
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110020#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reactant: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_b0944455_b2ea_435d_b137_b98c2844ed55
is: F8VQS7
is encoded by: hsa:55967
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110020#_642d3955_0247_4edc_80ba_f7b7edcdc9a6
boundary condition: true
initial concentration: NaN
name: GLUL
has only substance units: false
initial amount: NaN
is: P15104
type: Species
constant: false
is encoded by: hsa:2752
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_241dd2d5_19e1_42b3_9243_94c5fad821d3
has part: Q8WYR1
constant: false
is encoded by: hsa:23533
name: PIK3R5:PIK3CG
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN

metaM accoa n
initial amount: NaN
is: HMDB01206
name: acetyl-CoA(4-)
has only substance units: false
is: CHEBI:57288
constant: false
boundary condition: false
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
initial concentration: 1.0

metaR EICOSTETCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_fd66b525_7d20_400a_90da_ed97572065b8
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: HMGCR
is encoded by: hsa:3156
is: SBO:0000252
is: P04035

http://identifiers.org/biomodels.db/MODEL1310110020#_5ef20195_0f9c_451e_95fb_45ed5dbfeec6
constant: false
name: CCBL1
type: Species
initial amount: NaN
is encoded by: hsa:883
is: Q16773
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ca2 e
has only substance units: false
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
constant: false
name: calcium(2+)
is: HMDB00464
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29108

metaR r1631
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#

metaR RE0512M
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110020#

metaM val L m
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
is: SBO:0000247
name: L-valine
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16414
has only substance units: false
initial amount: NaN
is: HMDB00883

metaM bilirub c
type: Species
is: HMDB00054
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57977
name: bilirubin(2-)
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
has only substance units: false

metaM paf hs e
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
has only substance units: false
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
is: CHEBI:36707

metaR C60CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaM ksii core4 pre3 g
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial concentration: 1.0
is: C00130
is: SBO:0000247
type: Species

metaM co2 r
is: HMDB01967
has only substance units: false
initial amount: NaN
constant: false
name: CO2
is: SBO:0000247
boundary condition: false
is: CHEBI:16526
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: C00011

metaM g1m8masn r
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C76H127N2O60X CHARGE: 0
constant: false
is: C05875
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_df1ca861_bb1e_4fae_936d_51e51c5aea1c
has only substance units: false
is encoded by: hsa:10690
constant: false
name: FUT9
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: Q9Y231
initial amount: NaN

metaM 3mb2coa m
is: HMDB01493
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
name: 3-methylbut-2-enoyl-CoA(4-)
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57344
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

metaR r1630
is described by: ECO:0000000
kinetic law: MODEL1310110020#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
reversible: true

metaM pcrn m
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00824
has only substance units: false
name: propionyl-carnitine
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/107738

http://identifiers.org/biomodels.db/MODEL1310110020#_2a088400_ea5f_451e_aca9_1cde54abbae9
type: Species
boundary condition: true
is: P14060
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: HSD3B1
has only substance units: false
is encoded by: hsa:3283

http://identifiers.org/biomodels.db/MODEL1310110020#_83ad4026_bd5a_4214_bf56_eff48bfb957f
name: HK3
is: P52790
type: Species
is encoded by: hsa:3101
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR LEUPHELAT2tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR UGLCNACtg
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: true
name: UDP-GlcNAc Golgi transport via CMP antiport
reactant: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_7c6f2a7e_91ad_4ba6_9f89_853905f3e624
has only substance units: false
is encoded by: hsa:123041
type: Species
is: Q8NFF2
is: SBO:0000252
initial concentration: NaN
name: SLC24A4
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_459afcf0_d700_4eb1_8002_7c874b06db0d
is encoded by: hsa:2686
name: GGT7
is: A0PJJ9
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_d58d1cc2_3d6f_4a70_8058_53cdd3fcc45f
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
type: Species
boundary condition: true
has only substance units: false
has part: O95498
constant: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
is encoded by: hsa:8875

http://identifiers.org/biomodels.db/MODEL1310110020#_4b93618c_9ca9_4cce_9a31_04f4a51f5d92
is encoded by: hsa:8706
has only substance units: false
is: SBO:0000252
is: O75752
name: B3GALNT1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR NDPK6n
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
fast: false
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110020#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110020#

metaM ethamp c
constant: false
is: CHEBI:58190
name: ethamp[c]
is: HMDB00224
initial concentration: 1.0
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM dhf e
is: HMDB01056
boundary condition: false
type: Species
constant: false
is: CHEBI:57451
name: dihydrofolate(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_1dc6d77c_f809_42ec_9889_57b911e8d1ae
constant: false
name: _AA177072_1_c
type: Species
has only substance units: false
is encoded by: hsa:AA177072
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM 2octdectecoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
name: 2,6,9,12-octadecatetraenoylcoa
has only substance units: false

metaR TSTSTERONESte
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
name: sulfonated testosterone transport
product: MODEL1310110020#
is described by: ECO:0000000

metaR SERGLYexR
fast: false
product: MODEL1310110020#
name: L-Serine/Glycine reversible exchange
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110020#_2b652656_6ddf_4f2e_867d_91af4cf37539
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: _AI191472_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:AI191472

metaM ocdcea r
constant: false
initial concentration: 1.0
is: HMDB00207
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
is: C00712
initial amount: NaN
has only substance units: false
is: CHEBI:0
boundary condition: false
type: Species

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR r0377
reactant: MODEL1310110020#
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction

metaM dhf c
name: 7,8-Dihydrofolate
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
type: Species
is: C00415
boundary condition: false
constant: false
is: HMDB01056
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_81654669_866a_4f2d_a6a0_be50e9e702ee
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:H17063
name: _H17063_1_c
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaM retinal cis 13 r
is: SBO:0000247
is: HMDB06220
name: 13-cis-retinal
type: Species
is: CHEBI:45487
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR ICDHyrm
fast: false
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176

metaR BILDGLCURt
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
modifier: MODEL1310110020#

metaM mgacpail hs r
type: Species
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB00220
is: CHEBI:7896
is: SBO:0000247
is: C00249
initial amount: NaN
boundary condition: false
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_5186ac5d_8de0_4857_be0d_177b6d56f947
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5095
initial amount: NaN
is: SBO:0000252
name: PCCA
is: C9JPQ8

metaM 3hdeccoa c
boundary condition: false
name: 3-hydroxyhexadecenoylcoa
initial amount: NaN
is: HMDB02014
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial concentration: 1.0
type: Species

metaM retinol c
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:50211
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
is: SBO:0000247
name: retinol
is: HMDB00305

metaM accoa m
initial amount: NaN
is: HMDB01206
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
name: Acetyl-CoA
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57288
is: C00024

metaR S6T9g
type: Reaction
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a166e312_8c21_4d24_b224_aa4ec4de04db
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O60909
constant: false
is encoded by: hsa:8704
name: B4GALT2

metaR VALt4
reversible: false
is: SBO:0000185
reactant: MODEL1310110020#
name: L-valine transport in via sodium symport
is described by: ECO:0000304
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385
type: Species
name: Xanthine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17712
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00292
has only substance units: false

metaM retinol e
initial concentration: 1.0
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
boundary condition: false
name: retinol
has only substance units: false
is: HMDB00305
constant: false
is: CHEBI:50211
initial amount: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_3512e2b8_9bed_4583_9089_40bd3196338d
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC7A1
is: SBO:0000252
is: P30825
initial amount: NaN
constant: false
is encoded by: hsa:6541

metaR r1765
is: SBO:0000185
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000

metaM pnto R c
boundary condition: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
is: SBO:0000247
initial amount: NaN
is: HMDB00210
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:7916

metaR FAOXC225m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR EX 34hpp
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM cmp m
initial concentration: 1.0
type: Species
is: CHEBI:60377
name: CMP(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00095

metaM co2 m
is: CHEBI:16526
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: C00011
has only substance units: false
is: HMDB01967
name: CO2
boundary condition: false
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaR DURIt
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: deoxyuridine transport via diffusion
reversible: true

metaR PI345P3P
modifier: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
reversible: false
kinetic law: MODEL1310110020#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.67
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is described by: ECO:0000000

metaM 2obut m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16763
type: Species
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
name: 2-oxobutanoate

metaR SGALSIDEtl
product: MODEL1310110020#
type: Reaction
name: sgalside hs intracellular transport
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false

metaR RE0453C
is: SBO:0000176
name: RE0453
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_cbdda361_6f5e_4a27_9db9_a3a022003c14
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:BC005314
name: _BC005314_1_x
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM dec47dicoa m
is: SBO:0000247
boundary condition: false
name: 4,7-decadienoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN

metaR C3DCe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaM 3docopencoa m
constant: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: 3,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110020#_67d49f78_6ae5_4366_82d5_5ff8b2a4f6c3
constant: false
is encoded by: hsa:51179
is: SBO:0000252
type: Species
initial amount: NaN
name: HAO2
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_7a914e4d_b03b_485f_9bf9_fef6a4870005
is encoded by: hsa:1215
is: SBO:0000252
has only substance units: false
constant: false
is: Q4FEB3
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: CMA1

metaR ESTRADIOLt
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
name: estradiol transport
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110020#

metaR r1764
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110020#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110020#

metaM cmp n
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
initial amount: NaN
name: CMP(2-)
is: HMDB00095
type: Species
is: CHEBI:60377
boundary condition: false

metaR r1978
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110020#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_91b37221_9c70_41ab_976c_91be9b4115ac
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5052
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: PRDX1

metaM tmndnccoa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB06514
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_08d670c9_12d3_4b89_812e_9f91cb69272a
initial amount: NaN
type: Species
name: ACADL
constant: false
is encoded by: hsa:33
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P28330
is: SBO:0000252

metaR NDPK6m
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110020#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110020#
is described by: ECO:0000254
reversible: true
is: SBO:0000176

metaM ksi deg9 l
initial amount: NaN
type: Species
is: HMDB00143
name: keratan sulfate I, degradation product 9
constant: false
is: CHEBI:12936
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2c580bca_485d_4fbe_b6b6_8f6c47ef5891
is encoded by: hsa:55350
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110020#_91211577_cba2_4e83_be57_1571a2564895
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: GLA
constant: false
initial concentration: NaN
is: Q53Y83
has only substance units: false
is encoded by: hsa:2717

metaM asp L c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:29991
is: HMDB00191
has only substance units: false
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
constant: false
initial amount: NaN

metaR PRODt2r
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185
reactant: MODEL1310110020#
name: D-proline reversible transport via proton symport
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1b8b0617_a5c9_410a_8079_fd3ba5533212
constant: false
has only substance units: false
is: Q546Y9
is encoded by: hsa:57379
is: SBO:0000252
name: AICDA
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaM HC00591 m
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false

metaM 2dr5p c
type: Species
is: HMDB01031
has only substance units: false
initial amount: NaN
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
is: CHEBI:57651
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false

metaM c6dc x
initial concentration: 1.0
name: adipoyl carnitine
is: C14143
is: HMDB04047
initial amount: NaN
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaR NODe
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110020#
is described by: ECO:0000134
type: Reaction
name: NODe
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#

metaM val L c
initial amount: NaN
is: HMDB00883
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16414
name: L-valine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

http://identifiers.org/biomodels.db/MODEL1310110020#_b20e050c_6751_4b61_9aac_218fd5f6a4ad
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: _AI480132_1_c
is: SBO:0000252
is encoded by: hsa:AI480132
constant: false

metaR DLNLCGCPT2
modifier: MODEL1310110020#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: carnitine transferase
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR SCP21cx
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM ksii core2 pre6 g
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6

metaM cmpacna n
type: Species
is: SBO:0000247
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: CHEBI:57812
constant: false
boundary condition: false
is: HMDB01176

http://identifiers.org/biomodels.db/MODEL1310110020#_7fc2d791_fe89_4e42_828a_764a04407f1a
is encoded by: hsa:211
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: P13196
name: ALAS1
initial amount: NaN
has only substance units: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR RE0453N
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
name: RE0453
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR NACHEX15ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal

metaR RE3346M
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
fast: false
product: MODEL1310110020#
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

metaR DAG HSter
fast: false
kinetic law: MODEL1310110020#
name: diacylglycerol ER export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1b8716a2_253f_472f_8a9f_4f9714be8d1b
is: G3V4L5
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:89874
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: SLC25A21

metaM lald D c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17167
constant: false
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
initial concentration: 1.0
boundary condition: false

metaR LCAT1e
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.43
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
name: Lecithin-cholesterol acyltransferase

metaR ADSS
name: adenylosuccinate synthase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
is: SBO:0000176
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277

http://identifiers.org/biomodels.db/MODEL1310110020#_b47ca922_aeb9_4a44_974e_77361f31b37e
initial concentration: NaN
name: ACSS2
has only substance units: false
is: Q5QPH3
initial amount: NaN
is encoded by: hsa:55902
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaR FAOXC4C4DCc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_5dc0bb26_18bb_40f9_847b_d6f8c6274bc3
boundary condition: true
type: Species
is: C9JT23
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:126328
name: NDUFA11
constant: false
initial concentration: NaN

metaM glx x
initial amount: NaN
boundary condition: false
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: glyoxylate
is: HMDB00119
constant: false
type: Species

metaR EX c16dc
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaR FRDPtcr
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reactant: MODEL1310110020#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

metaM lnlncgcoa r
type: Species
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
boundary condition: false
is: HMDB06368
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b79dc8b7_863b_4bcc_8281_48f0169eef9e
has only substance units: false
is encoded by: hsa:27068
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PPA2
is: SBO:0000252

metaM pcrn c
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00824

metaM val L e
has only substance units: false
is: SBO:0000247
is: HMDB00883
name: L-valine
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaM acngalgbside hs g
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16523
constant: false
is: HMDB03406
name: sialyl galactosylgloboside
has only substance units: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cb84fa14_fce2_4730_a903_fbd381e189b7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3290
type: Species
constant: false
name: HSD11B1
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM ksi deg2 l
is: HMDB00573
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
has only substance units: false
type: Species
is: CHEBI:30825
name: keratan sulfate I, degradation product 2
constant: false

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
is: SBO:0000247
type: Species
is: CHEBI:16187
boundary condition: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
initial amount: NaN
is: HMDB01084
has only substance units: false
initial concentration: 1.0
constant: false

metaM cl c
notes: FORMULA: Cl CHARGE: -1
name: Chloride
type: Species
is: HMDB00492
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: C00115
is: CHEBI:3966

metaR COQ3m
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269
name: methyltransferase COQ3
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114
fast: false

metaM ksii core2 deg8 l
is: HMDB00143
is: CHEBI:12936
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247

metaM accoa x
is: C00024
is: HMDB01206
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57288
name: Acetyl-CoA
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
constant: false

metaR FAOXC160
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
product: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110020#

metaR IPDDIx
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/5.3.3.2
type: Reaction
kinetic law: MODEL1310110020#
name: isopentenyl-diphosphate D-isomerase
is: SBO:0000176
is described by: ECO:0000134
fast: false
modifier: MODEL1310110020#

metaR BDMT L
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.142
product: MODEL1310110020#
type: Reaction

metaM prostgi2 e
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
name: prostaglandin I2(1-)
is: CHEBI:57403
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaR r2193
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185

metaM cs e deg7 l
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15936
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
type: Species
notes: FORMULA: C23H35O27S2 CHARGE: -3

metaM fuc1p L c
is: SBO:0000247
name: L-Fucose 1-phosphate
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:28319
is: HMDB01265
initial concentration: 1.0
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030

metaR PMEVKc
kinetic law: MODEL1310110020#
fast: false
name: phosphomevalonate kinase, cytosol
product: MODEL1310110020#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
type: Reaction
reversible: false
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.2

metaM 2obut c
type: Species
is: C00109
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
is: CHEBI:16763
name: 2-Oxobutanoate

metaM dhf m
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01056
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
is: SBO:0000247
name: dihydrofolate(2-)
type: Species
is: CHEBI:57451

metaM csn e
initial concentration: 1.0
has only substance units: false
is: CHEBI:16040
name: cytosine
is: SBO:0000247
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
boundary condition: false
is: HMDB00630
initial amount: NaN
type: Species

metaM ser L c
constant: false
boundary condition: false
initial concentration: 1.0
name: L-serine
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
is: CHEBI:17115
is: HMDB00187
is: SBO:0000247
initial amount: NaN

metaR FACOAL161
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6827cd01_9649_4ec4_902a_c29480dd0a9f
is: B2RBR4
name: SLC20A2
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6575
is: SBO:0000252

metaR C161CPT12
kinetic law: MODEL1310110020#
fast: false
name: carnitine O-palmitoyltransferase
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000269

metaM 3mox4hpac m
type: Species
boundary condition: false
initial amount: NaN
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: HMDB05175
constant: false
has only substance units: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_cbe98509_2ab3_473f_9214_be59fd88f6ad
has only substance units: false
constant: false
initial concentration: NaN
is: A1L4Q0
type: Species
is encoded by: hsa:8526
initial amount: NaN
name: DGKE
is: SBO:0000252
boundary condition: true

metaM dhf l
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: dihydrofolate(2-)
initial amount: NaN
has only substance units: false
is: HMDB01056
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_27a4bc99_5ac8_43a8_95ac_afa7b65f9c68
is: SBO:0000252
initial concentration: NaN
is: Q8IW54
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5138
name: PDE2A
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_256f70d6_7aa7_474f_91b4_1cab599176bf
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:59272
constant: false
boundary condition: true
has only substance units: false
is: C7ECU1
name: ACE2
type: Species
is: SBO:0000252

metaR SGALSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
name: sgalside hs intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaM co2 x
boundary condition: false
is: SBO:0000247
is: HMDB01967
has only substance units: false
initial amount: NaN
name: carbon dioxide
initial concentration: 1.0
type: Species
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
is: CHEBI:16526

http://identifiers.org/biomodels.db/MODEL1310110020#_25b905b0_4cf0_4d72_a825_8b255bb54ec1
type: Species
name: GUCY2D
is encoded by: hsa:3000
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q02846
constant: false
has only substance units: false

metaM leuktrB4 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
has only substance units: false
is: CHEBI:57461
initial amount: NaN
initial concentration: 1.0
is: HMDB01085
name: leukotriene B4(1-)
type: Species
constant: false

metaR CITt4 4
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reactant: MODEL1310110020#
name: citrate transport via sodium symport
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000006

metaR 41R1H2MAE12BOOX
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.4
product: MODEL1310110020#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reversible: false
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_92806e07_1298_4385_aae9_8d05e7cd4af1
name: NOS1
is: B4DG68
is encoded by: hsa:4842
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM prostgi2 c
initial concentration: 1.0
name: prostaglandin I2(1-)
is: HMDB01335
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57403
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3ff226fb_5870_4d5b_aabc_c506a5c80a53
type: Species
initial concentration: NaN
is encoded by: hsa:123041
initial amount: NaN
has only substance units: false
name: SLC24A4
constant: false
is: SBO:0000252
boundary condition: true

metaR LSTO1r
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is: SBO:0000176
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
name: Lathosterol oxidase
type: Reaction
fast: false

metaR TAGt
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
name: triacylglycerol transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110020#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6acbfd11_e08c_4b90_8cf9_6f17a706bf6f
is: Q14916
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC17A1
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6568

metaM lnlncgcoa m
boundary condition: false
type: Species
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
is: CHEBI:57363
has only substance units: false
constant: false
initial concentration: 1.0

metaR SR5ARr
is: SBO:0000176
type: Reaction
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
product: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.5
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
modifier: MODEL1310110020#
is described by: ECO:0000134
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaM cl e
constant: false
has only substance units: false
type: Species
is: HMDB00492
is: C00115
initial amount: NaN
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
name: Chloride
is: CHEBI:3966
is: SBO:0000247

metaR GALGALGALTHCRMte
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110020#
name: galgalgalthcrm hs transport
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
fast: false

metaR DLNLCGCPT1
type: Reaction
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM asp L e
has only substance units: false
constant: false
type: Species
is: CHEBI:29991
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
name: L-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110020#_55be5855_920c_4924_ab02_1faa2c100598
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1717
initial amount: NaN
type: Species
is: SBO:0000252
name: DHCR7
is: Q9UBM7

http://identifiers.org/biomodels.db/MODEL1310110020#_39dffe94_74c4_4f13_b438_b69db6081288
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9HAY6
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:53630
name: BCMO1

metaM accoa r
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01206
has only substance units: false
name: acetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57288

http://identifiers.org/biomodels.db/MODEL1310110020#_1730e890_4a30_4a4d_89f1_94cfbd167f44
is encoded by: hsa:347734
initial amount: NaN
has only substance units: false
name: SLC35B2
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8TB61
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_bb1f6e54_8dd3_49b7_b588_6d649182a038
has part: P22392
type: Species
initial amount: NaN
name: NME1:NME2
is: SBO:0000297
is encoded by: hsa:4831
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830
has only substance units: false
has part: P15531

metaR AG13T6g
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM csn c
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00630
type: Species
name: cytosine
is: CHEBI:16040
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_dd8c421a_8122_45a7_b117_6f2a1448454c
is: SBO:0000252
type: Species
name: ACAT2
constant: false
initial concentration: NaN
is: Q9BWD1
is encoded by: hsa:39
has only substance units: false
boundary condition: true
initial amount: NaN

metaR CITt4 2
kinetic law: MODEL1310110020#
name: citrate transport via sodium symport
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reversible: true
is: SBO:0000185

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR DNDPt40m
product: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUTP transport via dADP antiport
modifier: MODEL1310110020#

metaM galgluside hs g
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58223
is: C00015
initial amount: NaN
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00295

metaR 3HKYNAKGAT
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
fast: false
product: MODEL1310110020#

metaR NDP8
is described by: ECO:0000269
fast: false
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
name: nucleoside-diphosphatase (dUDP)
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:

metaM 2octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355

metaM ksi pre2 g
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
is: C00130
is: HMDB00175
notes: FORMULA: C87H142N6O62X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 2
initial concentration: 1.0

metaM c101coa c
boundary condition: false
name: decenoylcoa
is: HMDB00651
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR RE1525M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: RE1525
fast: false
is described by: ECO:0000000

metaM cspg e l
type: Species
is: HMDB02183
constant: false
is: CHEBI:36005
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_622dd973_2dbb_4f23_8acf_43308ac21bca
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN

metaR GALGALGALTHCRMtg
is: SBO:0000185
kinetic law: MODEL1310110020#
fast: false
type: Reaction
product: MODEL1310110020#
name: galgalgalthcrm hs intracellular transport
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
reversible: true

metaR DNADtn
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
reversible: true
name: dNAD transport, nuclear trhough pore
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaM ksii core4 pre1 g
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: CHEBI:28067
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 1
has only substance units: false

metaR ADSK
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
name: adenylyl-sulfate kinase

metaM tmndnccoa c
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: timnodonyl coenzyme A
is: HMDB06514
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_ff8751e7_5aa6_457a_a0a0_a64a82a54a06
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A
type: Species

metaM ksi deg33 l
is: HMDB00143
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 33
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: CHEBI:12936
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_345fe790_c50d_4aa6_9db8_1e643f3de2a7
is encoded by: hsa:AI653169
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: _AI653169_1_c
has only substance units: false

metaM m6mpdol L r
type: Species
is: CHEBI:37635
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM HC02203 c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: prostaglandin-a2
constant: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820

metaM dolmanp L c
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
is: CHEBI:15809
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0

metaM ocdcea e
is: HMDB00207
is: C00712
name: octadecenoate (n-C18:1)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
constant: false
has only substance units: false
boundary condition: false

metaM tetdec2crn c
type: Species
initial concentration: 1.0
is: HMDB02014
boundary condition: false
initial amount: NaN
has only substance units: false
name: tetradecadienoyl carnitine
constant: false
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0

metaR GLACter
is: SBO:0000185
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true

metaM dec47dicoa x
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 4,7-decadienoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaM 4nph e
is: SBO:0000247
initial concentration: 1.0
is: HMDB01232
is: CHEBI:57917
name: 4-nitrophenolate
boundary condition: false
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
constant: false
has only substance units: false

metaM hs deg9 l
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
initial concentration: 1.0
is: CHEBI:18268
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 9
constant: false
is: HMDB06355
has only substance units: false

metaM hdcoa c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
type: Species
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaR PIACGT
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.198
name: phosphatidylinositol N-acetylglucosaminyltransferase
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176

metaM co2 c
constant: false
is: CHEBI:3313
initial concentration: 1.0
name: CO2
has only substance units: false
is: SBO:0000247
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0
initial amount: NaN
type: Species
is: C00011
boundary condition: false

metaM cmp c
constant: false
initial concentration: 1.0
is: HMDB00095
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP
is: CHEBI:60377
initial amount: NaN
type: Species
is: C00055
boundary condition: false

metaR AGMTm
kinetic law: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
name: agmatinase (m)
type: Reaction
notes: GENE_ASSOCIATION: (79814.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES:SAB m
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.3.11
reactant: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_91506f6a_5c8b_4374_9e5d_45a0f4d19be8
is: P46952
initial amount: NaN
name: HAAO
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:23498
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM ahdt e
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58462
is: HMDB00980
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
name: 7,8-dihydroneopterin 3'-triphosphate(4-)

metaR C4tcx
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM l2n2m2mn l
constant: false
has only substance units: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: SBO:0000247
type: Species
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)

http://identifiers.org/biomodels.db/MODEL1310110020#_e96e3d09_24ad_40af_b09c_4f7a72f2a931
is encoded by: hsa:2720
boundary condition: true
initial concentration: NaN
type: Species
name: GLB1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P16278

metaM hexde7coa x
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02288
initial amount: NaN
constant: false
name: 7-hexadecenoylcoa
has only substance units: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_01576885_1e3f_4c63_91f3_cc819c2eacbf
is: B7Z6S9
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: GBA
has only substance units: false
is encoded by: hsa:2629
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_ed70d28e_1595_472c_b8bf_c31cd629e635
is encoded by: hsa:1719
boundary condition: true
is: SBO:0000252
has only substance units: false
name: DHFR
initial amount: NaN
is: P00374
initial concentration: NaN
type: Species
constant: false

metaR G14T3g
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9ba5aa57_deda_44f4_a5aa_46e9e4d3d8b6
has only substance units: false
is encoded by: hsa:1347
is: H0UI06
boundary condition: true
initial concentration: NaN
type: Species
name: COX7A2
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_470e589c_ed7e_4287_9f69_80a964b9956e
initial amount: NaN
is: Q96G03
initial concentration: NaN
has only substance units: false
constant: false
name: PGM2
is: SBO:0000252
is encoded by: hsa:55276
boundary condition: true
type: Species

metaM dolglcp L r
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:15812
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d346dec9_bfe0_4aa4_9bef_6605c1e2708e
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:4717
is: SBO:0000252
initial concentration: NaN
name: NDUFC1
boundary condition: true
is: O43677
has only substance units: false

metaM HC02203 e
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: prostaglandin-a2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
is: SBO:0000247

metaM zymst r
name: zymosterol
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
has only substance units: false
is: HMDB06271
initial concentration: 1.0
is: CHEBI:18252
is: SBO:0000247

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM zym int2 r
constant: false
is: CHEBI:52386
type: Species
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
is: SBO:0000247
initial concentration: 1.0
name: zymosterol intermediate 2
initial amount: NaN
boundary condition: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a0a804e5_b49e_4c81_a6b7_63c2d9fe658b
type: Species
initial concentration: NaN
is: SBO:0000252
name: GUCY2F
boundary condition: true
is: P51841
is encoded by: hsa:2986
initial amount: NaN
constant: false
has only substance units: false

metaR ALDD2xm
reactant: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110020#
is described by: ECO:0000134
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6c02aa1c_8b1c_40ea_9035_63efe2c308f7
is: Q9NY65
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1962
name: EHHADH
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM 2docopencoa m
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
constant: false

metaM tetdec2crn e
is: HMDB05066
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: tetradecadienoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_40d94f39_3ed4_46ac_a114_7883981ae5f8
constant: false
name: AMPD3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:272
is: B7Z763
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaM hs deg23 l
has only substance units: false
is: HMDB02704
is: SBO:0000247
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338
type: Species

metaR RE3006M
is described by: ECO:0000000
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110020#
name: RE3006
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110020#

metaM gum e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97415
type: Species
constant: false
boundary condition: false
name: gums

metaM ptdcacrn m
initial concentration: 1.0
name: pendtadenoyl carnitine
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721
boundary condition: false
has only substance units: false
is: CHEBI:15811
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR LEUtec
modifier: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110020#
name: L-leucine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
fast: false

metaM ps hs m
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
name: ps_hs[m]
is: SBO:0000247

metaM acgpail hs c
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
initial concentration: 1.0
boundary condition: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57265
constant: false
has only substance units: false

metaR FAOXC184x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR H2Otly
product: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
name: H2O transport, lysosomal
is: SBO:0000185
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f030fd81_fcc3_4c80_9d83_0908e3b483f7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3157
constant: false
type: Species
initial amount: NaN
name: HMGCS1
initial concentration: NaN
has only substance units: false

metaR RE3347C
reversible: true
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
name: RE3347
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_b5448da8_cdb2_4c81_a756_db45f82e60f7
is: P07864
is encoded by: hsa:3948
name: LDHC
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaR GGH 5DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110020#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR GLCNACASE3ly
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM pre prot r
boundary condition: false
is: SBO:0000247
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: CHEBI:16038
notes: FORMULA: XY CHARGE: 0
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DHFtl
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
type: Reaction
name: dihydrofolate reversible lysosomal transport
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM betald c
initial concentration: 1.0
initial amount: NaN
is: HMDB01252
is: CHEBI:15710
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
is: SBO:0000247
boundary condition: false
name: betaine aldehyde
type: Species

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM ksi deg10 l
boundary condition: false
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16953
has only substance units: false
name: keratan sulfate I, degradation product 10
is: HMDB00812
is: SBO:0000247
initial amount: NaN

metaR LEUKTRF4t
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene F4 transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR INSTt4
is: SBO:0000185
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
name: inositol transport via sodium symport

metaM HC01104 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial concentration: 1.0
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_8c77c13d_03fa_46ef_9e05_e940d632704a
is encoded by: hsa:54576
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: UGT1A8
boundary condition: true
is: Q5DSZ6
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3a0f9985_c0d2_4b27_80e5_0b496d4f5bf8
boundary condition: true
name: MTMR3
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:8897

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110020#_4e6b7ce8_3680_4eb3_9ad7_561c6199528d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
type: Species
name: ACAA1
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_872facc0_4011_4c8e_9479_ee33929b1310
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:26289
is: SBO:0000252
name: AK5
has only substance units: false
constant: false

metaM itacon m
has only substance units: false
constant: false
is: CHEBI:17240
is: HMDB02092
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
type: Species

metaR LNLCCRNt
name: transport into the mitochondria (carnitine)
is: SBO:0000185
type: Reaction
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000269
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR APOCFm
reversible: false
reactant: MODEL1310110020#
name: Apocarboxylase formation, mitochondrial
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#

metaR G16MT L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110020#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false

metaR S6TASE21ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1500e670_5936_483c_8076_45aaa4989d37
name: PPA2
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: F8WDN9
type: Species
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110020#_7795220f_80b0_4e4a_bf8d_159010184e0c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: B3GALT5
constant: false
boundary condition: true
is encoded by: hsa:10317
has only substance units: false

metaR DHFtm
is described by: ECO:0000000
name: dihydrofolate reversible mitochondrial transport
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
product: MODEL1310110020#
fast: false
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaM ocdcea c
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: SBO:0000247
is: HMDB00207
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:0

metaR TRPATB0tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tryptophan into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_607cbe06_baf0_42fa_b4cd_d09292be0ad2
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NDUFA5
is encoded by: hsa:4698
is: Q16718
has only substance units: false
constant: false

metaR ACITL
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110020#
name: ATP-Citrate lyase
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is version of: http://identifiers.org/ec-code/2.3.3.8
reversible: false
reactant: MODEL1310110020#

metaR GCHOLAte
name: bile acid intracellular transport
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f4e21c08_f2a1_4a31_a8f4_5b4080409a55
is encoded by: hsa:277
initial concentration: NaN
is: P04745
initial amount: NaN
has only substance units: false
name: AMY1B
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
is: CHEBI:26174
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_6e56388a_165a_418c_94f0_f377740b1083
name: PRDX2
has only substance units: false
is encoded by: hsa:7001
constant: false
initial amount: NaN
is: P32119
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaM pentcoa m
is: C00888
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB13037
is: SBO:0000247
name: pentanoylcoa
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_182064af_9e97_454c_9b98_043ec0e2419a
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1178
type: Species
is: C5HZ13
constant: false
boundary condition: true
name: CLC

metaR q10tm
reversible: true
reactant: MODEL1310110020#
type: Reaction
name: transport of ubiquinone into mitochondria
fast: false
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110020#

metaM ptdcacoa c
is: SBO:0000247
name: pentadecanoyl Coenzyme A
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB06499
type: Species
initial amount: NaN

metaR RE3624M
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: RE3624
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_174d5f76_07fc_4eae_9b49_41ddedc921b7
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: E7EPT3
is encoded by: hsa:501
boundary condition: true
name: ALDH7A1

metaM ivcoa c
initial concentration: 1.0
type: Species
is: HMDB01113
has only substance units: false
constant: false
name: Isovaleryl-CoA
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110020#_733dd24b_bea9_4212_ae98_7da9f708956d
boundary condition: true
has only substance units: false
type: Species
name: NDUFA4
is: O00483
is encoded by: hsa:4697
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR HMGCOASi
reversible: false
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_50eaa64e_bcb1_4e8a_87a7_c0ef17de8423
initial concentration: NaN
is: SBO:0000252
is: P49327
is encoded by: hsa:2194
initial amount: NaN
has only substance units: false
boundary condition: true
name: FASN
type: Species
constant: false

metaR RBFK
name: riboflavin kinase
modifier: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false
reversible: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.26
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction

metaR r0591
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_e853fded_9e23_4bbc_8aa7_633f661c2ed4
initial amount: NaN
is encoded by: hsa:2678
boundary condition: true
has only substance units: false
name: GGT1
is: SBO:0000252
is: P19440
initial concentration: NaN
type: Species
constant: false

metaM clpndcoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
has only substance units: false
is: C16166
is: HMDB06267
name: clupanodonyl CoA
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205476
type: Species

metaM CE4724 e
is: C01936
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5041
name: apelin (1-12)
has only substance units: false
notes: FORMULA: C60H105N22O15S CHARGE: 3 INCHI: InChI=1/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/p+3/t35-,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1 EHMN_ABBREVIATION: CE4724

metaR r1629
reactant: MODEL1310110020#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_bd7bca69_6e70_42e0_a903_19561e02f7a5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5140
initial amount: NaN
name: PDE3B
has only substance units: false
constant: false
type: Species
is: Q13370
boundary condition: true

metaR C80CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR MM7B2g
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110020#

metaR GCCam
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein), mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR C161OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_7d77d1bd_4f1b_4937_bc56_5c846ae875a0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:957
constant: false
initial concentration: NaN
name: ENTPD5
is: O75356
boundary condition: true

metaR C204CRNt
fast: false
reversible: false
name: arachidonic acid transport into the mitochondria
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#

metaM xoltriol m
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01457
is: CHEBI:16496
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol

metaM 3tdcrn c
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: 3-hydroxy-tetradecanoyl carnitine
type: Species
notes: FORMULA: C21H41NO5 CHARGE: 0
is: HMDB02014
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_bf324cbe_16e0_4247_a3d0_e89e9a0e6c3f
boundary condition: true
constant: false
initial concentration: NaN
is: Q9BYC2
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: OXCT2
type: Species
is encoded by: hsa:64064

http://identifiers.org/biomodels.db/MODEL1310110020#_0bf3c25f_d8b9_4b1c_b08c_3c086ac47578
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI926493
constant: false
name: _AI926493_1_m

W3 CDTF: Fri Aug 31 00:43:31 BST 2012

metaR r0142
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3

metaM bildglcur r
is: CHEBI:58471
boundary condition: false
type: Species
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false

metaR DADNt4
name: deoxyadenosine transport via diffusion
fast: false
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR UMPK4n
modifier: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
name: UMP kinase (GTP),nuclear
is described by: ECO:0000269
product: MODEL1310110020#

metaR NACHEX16ly
modifier: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

metaM pnto R e
is: SBO:0000247
type: Species
boundary condition: false
name: (R)-Pantothenate
initial amount: NaN
is: HMDB00210
is: CHEBI:7916
constant: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0

metaM ptdcacrn c
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721
is: CHEBI:15811
boundary condition: false
type: Species
has only substance units: false
name: pendtadenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110020#_473dddeb_1f52_44e7_a8c8_34b0589c5161
initial amount: NaN
is: P27708
type: Species
name: CAD
is encoded by: hsa:790
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR GLNCYSNaEx
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110020#
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_efecc668_82c4_49ae_a1a9_11d6ba366718
boundary condition: true
is encoded by: hsa:594
type: Species
name: BCKDHB
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: P21953

http://identifiers.org/biomodels.db/MODEL1310110020#_4af97b8a_d072_42d4_b8a3_520adc2b7629
initial amount: NaN
is: Q1ET61
type: Species
is encoded by: hsa:6818
boundary condition: true
initial concentration: NaN
name: SULT1A3
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1526485d_f646_49c0_ba50_d6d02c548372
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4166
is: Q9GZX3
initial amount: NaN
type: Species
name: CHST6
is: SBO:0000252
has only substance units: false
constant: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_f805661f_2f55_4a93_b40b_1626a6216aaa
boundary condition: true
is encoded by: hsa:4967
initial concentration: NaN
initial amount: NaN
constant: false
has part: B4E3E9
has only substance units: false
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_ec3dea0c_d50b_4563_8db6_b5b134d7dd6d
is encoded by: hsa:3418
initial amount: NaN
type: Species
name: IDH2
is: P48735
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaR DRIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
name: deoxyribose transport via diffusion
is: SBO:0000185
fast: false
reactant: MODEL1310110020#

W3 CDTF: Fri Aug 31 00:43:32 BST 2012

metaM lnlncgcoa c
constant: false
initial amount: NaN
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57363
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_620d1d8b_683b_4bc5_b9a0_aec9f9e4e270
name: PYCR2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:29920
initial amount: NaN
is: Q96C36
has only substance units: false

metaR GAPD
product: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: true
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is described by: ECO:0000134
reactant: MODEL1310110020#
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4d893b36_4f65_4875_b5d8_fec829dfe975
type: Species
initial amount: NaN
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
name: PANK2
is: SBO:0000252
boundary condition: true
constant: false

metaM o2 c
name: O2
initial amount: NaN
constant: false
is: CHEBI:15379
type: Species
boundary condition: false
is: C00007
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR r1627
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_1d0498b2_143c_4d38_9db6_5205aa695371
initial concentration: NaN
type: Species
is encoded by: hsa:R06874
has only substance units: false
constant: false
boundary condition: true
name: _R06874_1_r
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_b6b7d6ab_be8c_4e82_8162_083f05b14e64
type: Species
is: Q92523
name: CPT1B
is encoded by: hsa:1375
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR GASNASE3ly
is described by: ECO:0000000
reversible: false
product: MODEL1310110020#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d2c352a3_e8dc_4743_adc5_5615023e9d5e
is: SBO:0000252
is encoded by: hsa:1374
initial amount: NaN
initial concentration: NaN
is: Q8WZ48
type: Species
name: CPT1A
constant: false
boundary condition: true
has only substance units: false

metaR DNDPt10m
type: Reaction
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dCDP antiport

metaR LNELDCCRNt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
name: transport into the mitochondria (carnitine)
reversible: false

metaR r0145
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.8.3.1
kinetic law: MODEL1310110020#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:

metaR UPPN
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
name: b-ureidopropionase
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction

metaM 3docopencoa x
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/24892790
name: 3,7,10,13,16-docosapentenoylcoa
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_7b67205a_8a69_47f3_990a_4194b8127117
initial concentration: NaN
is encoded by: hsa:80271
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: Q96DU7
name: ITPKC

metaM ksi deg41 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 41
initial amount: NaN
type: Species
is: CHEBI:12936
notes: FORMULA: C34H58N2O26 CHARGE: 0

metaM ksii core2 pre7 g
is: HMDB00175
constant: false
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
type: Species
notes: FORMULA: C67H108N5O51SX CHARGE: -2
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR FOAXC122C101x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR CMPSAS
name: CMP sialic acid synthase
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false
is described by: ECO:0000304

metaR r1628
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0
boundary condition: false
is: HMDB06532

http://identifiers.org/biomodels.db/MODEL1310110020#_5de7c092_bc0f_4492_bb0d_d4e620a5779a
name: GBA
initial concentration: NaN
constant: false
is: B7Z6S1
is: SBO:0000252
type: Species
is encoded by: hsa:2629
boundary condition: true
initial amount: NaN
has only substance units: false

metaR C3STKR2r
is described by: ECO:0000134
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
name: C-3 sterol keto reductase (zymosterol)
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
reversible: false

metaR FAOXC226C205m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_3b5023af_006c_43d7_ae0d_0c06cbefb439
boundary condition: true
is: P11310
name: ACADM
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110020#_6613cab8_f2d3_4550_8e8b_85ea1c85b1e7
is: SBO:0000252
name: MCCC2
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9HCC0
is encoded by: hsa:64087
has only substance units: false
type: Species
boundary condition: true

metaR GALtly
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: galactose efflux from lysosome

metaM ksi pre5 g
is: CHEBI:28067
boundary condition: false
type: Species
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 5
initial concentration: 1.0
notes: FORMULA: C101H164N7O75SX CHARGE: -2
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_63e4a6ef_55b2_4fa5_b66d_cdaf5c8f0f51
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54963
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: UCKL1
is: Q53HM1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_f8ee878f_2b0a_44ed_80cd_8364bef22d64
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: P56134
is encoded by: hsa:9551
name: ATP5J2

metaR r1625
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
modifier: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR r0595
reactant: MODEL1310110020#
is: SBO:0000176
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
reversible: false
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
type: Reaction
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_7c62130e_730e_4c8d_a13d_d972c869bb95
name: GUCY2C
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2984
type: Species
initial concentration: NaN
has only substance units: false
is: P25092

metaM ps hs e
constant: false
name: phosphatidylserine
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
boundary condition: false

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR PTE4x
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
type: Reaction
name: peroxisomal acyl-CoA thioesterase
modifier: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2

metaR RE3556C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
is: SBO:0000176
name: RE3556
fast: false
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_3a5531f7_eed3_4e62_b381_f5b8c9850737
boundary condition: true
is: SBO:0000252
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR SMPD3g
product: MODEL1310110020#
type: Reaction
fast: false
reactant: MODEL1310110020#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is version of: http://identifiers.org/ec-code/3.1.4.12
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR C81CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR r0594
fast: false
reactant: MODEL1310110020#
type: Reaction
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
product: MODEL1310110020#

metaM 5hoxindact c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
boundary condition: false
is: CHEBI:50157
constant: false
name: (5-hydroxyindol-3-yl)acetaldehyde
has only substance units: false
is: HMDB04073
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_eaf7b663_4767_4916_ae65_82eba5b689ff
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: P17516
initial amount: NaN
is encoded by: hsa:1109
name: AKR1C4
initial concentration: NaN

metaM cmp g
has only substance units: false
is: SBO:0000247
name: CMP(2-)
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
is: CHEBI:60377
initial amount: NaN

metaR ADMDC
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.1.50
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is: SBO:0000176
fast: false
reversible: false
type: Reaction
product: MODEL1310110020#
name: adenosylmethionine decarboxylase
reactant: MODEL1310110020#
is described by: ECO:0000269

metaR THRASNNaEx
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110020#

metaM c6dc c
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00705
name: adipoyl carnitine
notes: FORMULA: C13H22NO6 CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247

metaR r1626
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_012c11e8_41af_47f9_b639_682dbe29aa17
type: Species
is: Q546E0
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2530
constant: false
boundary condition: true
initial concentration: NaN
name: FUT8
has only substance units: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR FAOXC184m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR OMPDC
product: MODEL1310110020#
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_cd55caa8_4c0f_405f_9476_7f73cfa05209
is: A6NFM2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5831
name: PYCR1

metaR DOCO13EFATP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR r1623
fast: false
is: SBO:0000185
modifier: MODEL1310110020#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaR r0149
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR FUMTSULtm
name: Fumarate:thiosulfate antiport, mitochondrial
reversible: true
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
product: MODEL1310110020#

metaM ksi deg5 l
is: CHEBI:12936
constant: false
initial concentration: 1.0
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 5
initial amount: NaN
is: SBO:0000247
is: HMDB00143
has only substance units: false

metaR GGH 5DHFl
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
is: SBO:0000176
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reversible: false

metaR FAS100COA
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty acyl-CoA synthase (n-C10:0CoA)
reversible: false
is: SBO:0000176
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false

metaM ocdcea l
is: CHEBI:30823
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
name: oleate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00207
constant: false

metaM pcrn x
name: propionyl-carnitine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
is: HMDB00824
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
constant: false

metaR FTHFL
is described by: ECO:0000134
kinetic law: MODEL1310110020#
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#

metaM 3tdcrn e
initial concentration: 1.0
name: 3-hydroxy-tetradecanoyl carnitine
notes: FORMULA: C21H41NO5 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB13336
type: Species
is: SBO:0000247

metaM ksi pre13 g
initial concentration: 1.0
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 13
constant: false
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
boundary condition: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110020#_efc05eba_effb_47a3_87c7_7fb269ed3bfd
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: _AI656480_1_m
initial amount: NaN
is encoded by: hsa:AI656480
boundary condition: true
initial concentration: NaN

metaM ksi pre3 g
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 3
is: C00130
initial concentration: 1.0
is: HMDB00175
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM ksi pre20 g
is: SBO:0000247
constant: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 20
initial concentration: 1.0
boundary condition: false

metaR S3TASE3ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110020#

metaR HS2ly
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_045af567_85a9_495a_a5f5_eb3360003c4f
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10317
name: B3GALT5
type: Species
constant: false

metaR r0596
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#

metaR r1624
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110020#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_7563411e_4963_49b6_b12b_a1736fdc8fdf
initial amount: NaN
initial concentration: NaN
type: Species
name: ACAA1:HSD17B4:ACOX1
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3295
is: SBO:0000297
has part: E9PB82

http://identifiers.org/biomodels.db/MODEL1310110020#_3fced0e4_0764_40cb_95e2_5d4f2a011c47
type: Species
name: SLC33A1
boundary condition: true
is: O00400
is: SBO:0000252
constant: false
is encoded by: hsa:9197
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM co2 e
is: HMDB01967
is: SBO:0000247
boundary condition: false
is: CHEBI:16526
initial concentration: 1.0
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
is: C00011
name: CO2
has only substance units: false
initial amount: NaN

metaM cmp e
name: CMP(2-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
constant: false
is: CHEBI:60377
has only substance units: false
initial amount: NaN

metaM 4nph c
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57917
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM 4mtolbutamide e
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
boundary condition: false
name: 4 hydroxy tolbutamide
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06408

metaM hs deg5 l
boundary condition: false
name: heparan sulfate, degradation product 5
type: Species
is: SBO:0000247
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
has only substance units: false
is: HMDB00158
initial amount: NaN
is: CHEBI:17895
constant: false
initial concentration: 1.0

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true

metaM hs deg12 l
initial amount: NaN
initial concentration: 1.0
constant: false
name: heparan sulfate, degradation product 12
boundary condition: false
is: HMDB01352
is: CHEBI:17180
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7

metaM ru5p D r
is: HMDB00618
is: CHEBI:58121
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: D-ribulose 5-phosphate(2-)
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_53132878_2326_40d7_b1d4_01741c05c2f3
boundary condition: true
name: NDUFAB1
is: SBO:0000252
is encoded by: hsa:4706
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O14561
has only substance units: false

metaR LNLNCGCPT1
fast: false
reactant: MODEL1310110020#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_e19b9a4c_f671_4dd6_b02f_a4e09c966299
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: ADCY5
is: O95622
is encoded by: hsa:111

metaM CE0713 m
is: CHEBI:30623
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
has only substance units: false
type: Species
initial amount: NaN
name: 3-oxolinoleoyl-CoA
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110020#_cab7eef3_8561_4b45_8cbf_dbadbdbaf851
is encoded by: hsa:91373
name: UAP1L1
has only substance units: false
constant: false
initial amount: NaN
is: Q3KQV9
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR DNDPt28m
type: Reaction
name: dCDP transport via dGDP antiport
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110020#
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110020#
reversible: false

metaM 34hpp e
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00707
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: CHEBI:36242
initial amount: NaN

metaR r2497
reversible: false
type: Reaction
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_766b3f69_2011_42e5_9e2f_0552d0504cbd
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:171425
has only substance units: false
name: CLYBL
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_49e37308_3adc_4823_a6a6_8c349f916320
boundary condition: true
initial amount: NaN
constant: false
name: NPR2
is: P20594
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4882

metaM trdrd c
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: SBO:0000247
is: CHEBI:15967
is: C00342
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_5941053c_3626_40ad_9412_fd20735f5e47
constant: false
initial amount: NaN
type: Species
is: O75610
is encoded by: hsa:10637
initial concentration: NaN
name: LEFTY1
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM ksii core2 l
has only substance units: false
is: HMDB03418
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:16443
name: keratan sulfate II (core 2-linked)

metaM atp x
initial concentration: 1.0
name: ATP(4-)
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247
is: HMDB00538
type: Species
is: C00002
has only substance units: false
boundary condition: false
constant: false

metaM ksi deg25 l
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB00812
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN
name: keratan sulfate I, degradation product 25
boundary condition: false

metaR LNSTLSr
name: lanosterol synthase
is version of: http://identifiers.org/ec-code/5.4.99.7
type: Reaction
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000134
reactant: MODEL1310110020#
reversible: false
is: SBO:0000176
fast: false

metaR TYRTA
kinetic law: MODEL1310110020#
type: Reaction
name: tyrosine transaminase
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR CYTK2n
is described by: ECO:0000269
product: MODEL1310110020#
is: SBO:0000176
name: cytidylate kinase (dCMP),nuclear
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_7fbd0714_a62c_4ed4_9d1a_e72a762590d9
boundary condition: true
is encoded by: hsa:3939
is: P00338
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: LDHA
initial amount: NaN
constant: false

metaR ACNAMlt
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
name: N-acetylneuraminate transport into lysososme
modifier: MODEL1310110020#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is described by: ECO:0000269
product: MODEL1310110020#

metaM fe2 e
type: Species
initial concentration: 1.0
is: CHEBI:29033
is: HMDB00692
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
name: Fe2+
is: SBO:0000247
constant: false

metaM sgalside hs g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58343
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00061
name: sulfatide galactocerebroside
constant: false
type: Species

metaM dcdp c
is: HMDB01245
has only substance units: false
name: dCDP
boundary condition: false
initial concentration: 1.0
is: CHEBI:58593
is: C00705
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
initial amount: NaN

metaR FAOXC226C225m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_96f48490_68a4_48cd_b588_272621008da9
is: SBO:0000252
name: AGXT2L1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:64850
constant: false
is: Q8TBG4
has only substance units: false

metaR PHEt4
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: L-phenylalanine transport in via sodium symport
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7754fbec_b4f9_4282_b6e3_ddbe5bd37d26
boundary condition: true
is encoded by: hsa:AI222095
name: _AI222095_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR PEROXx
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: peroxisomal lumped long chain fatty acid oxidation
is: SBO:0000176

metaM adp c
is: C00008
name: ADP
boundary condition: false
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16761
constant: false
type: Species

metaR C226CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
name: carnitine C22:6 transferase
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false

metaR r1622
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4f816b72_85b5_468a_be11_b4d6960e1773
is: Q9NRA0
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: SPHK2
is: SBO:0000252
is encoded by: hsa:56848
boundary condition: true
initial amount: NaN

metaM hpdcacoa c
name: heptadecanoyl coa
has only substance units: false
initial amount: NaN
is: HMDB06497
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR PPA
modifier: MODEL1310110020#
product: MODEL1310110020#
name: inorganic diphosphatase
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110020#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_16025154_e7a3_4f4a_9f1f_4ed959093f23
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:7841
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: MOGS
is: F5H6D0

metaR Uritn
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: uridine transport in nucleus
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM core3 g
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
is: CHEBI:16250
initial amount: NaN
has only substance units: false
name: Core 3
boundary condition: false
type: Species
constant: false

metaR FAOXC165C164x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM 5fthf m
initial concentration: 1.0
name: 5-formyltetrahydrofolate(2-)
constant: false
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57457
is: SBO:0000247

metaR 3MOPt2im
kinetic law: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110020#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110020#
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaM xoltriol c
type: Species
is: HMDB01457
is: CHEBI:16496
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial amount: NaN
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_54973989_1729_47d3_880d_16980b0c4b81
boundary condition: true
name: NDUFA6
initial amount: NaN
has only substance units: false
type: Species
is: P56556
is encoded by: hsa:4700
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a289e100_4f20_480b_8360_a52de259ca93
is encoded by: hsa:1558
initial concentration: NaN
initial amount: NaN
is: P10632
constant: false
name: CYP2C8
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_0561e591_6390_4d1e_b236_f8c643fd2145
has only substance units: false
constant: false
is encoded by: hsa:54677
name: CROT
initial amount: NaN
is: E7EQF2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR r1750
product: MODEL1310110020#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction

metaR r1621
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110020#_2e00508d_1055_4978_b890_82c55c17e726
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4832
type: Species
is: Q13232
initial concentration: NaN
name: NME3
has only substance units: false
initial amount: NaN

metaM HC02210 c
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: prostaglandin-d3

metaM dmhptcrn e
name: 2,6 dimethylheptanoyl carnitine
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06320
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

http://identifiers.org/biomodels.db/MODEL1310110020#_ab241fa5_a3bc_4167_b711_f9096f9ac91d
constant: false
name: OXCT1
is: SBO:0000252
is encoded by: hsa:5019
is: P55809
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM tetpent3coa c
is: SBO:0000247
is: C16167
name: tetracosapentaenoyl coenzyme A, n-3
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR SEBACIDTD
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR LAPCOAl
reversible: false
fast: false
name: lysosomal acid phosphorylase (CoA)
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
is described by: ECO:0000304
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM fe2 c
initial concentration: 1.0
is: HMDB00692
name: Fe2+
is: CHEBI:29033
boundary condition: false
is: C00023
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false

metaR FAOXC185m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR FAOXC121C101m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaM dhlam m
boundary condition: false
name: dihydrolipoamide
has only substance units: false
is: HMDB00985
constant: false
type: Species
is: CHEBI:17694
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579

metaR r0385
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110020#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110020#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1f4cffd0_9843_41d4_ac7f_1efdb2942ed0
has only substance units: false
is encoded by: hsa:AA203143
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AA203143_1_c

metaM adp e
is: HMDB01341
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:456216
name: ADP(3-)
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaM acetol c
has only substance units: false
boundary condition: false
is: HMDB06961
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
is: CHEBI:27957
name: hydroxyacetone

metaR AMETt2m
reactant: MODEL1310110020#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is described by: ECO:0000269
modifier: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_42ed8966_cd95_4fca_ad77_f961fdba7776
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: TXNRD1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7296
type: Species

metaR r2308
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true

metaR S6TASE20ly
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110020#
reversible: true

metaM tdchola e
boundary condition: false
has only substance units: false
is: CHEBI:9407
is: HMDB00951
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: taurochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaR r0801
fast: false
reactant: MODEL1310110020#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_7ae32ead_f0ea_4f5c_82c8_1787b29549e6
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:27068
is: SBO:0000252
is: Q9H2U2
initial concentration: NaN
has only substance units: false
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110020#_41196b30_06bd_44c7_b50c_be415b8b5168
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:218
constant: false
boundary condition: true
initial amount: NaN
is: P30838
has only substance units: false
name: ALDH3A1

metaM sgalside hs l
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
initial amount: NaN
name: sulfatide galactocerebroside
type: Species
is: HMDB00904
constant: false
initial concentration: 1.0
is: CHEBI:16349
has only substance units: false

metaR S6TASE12ly
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR PCLAD
is described by: ECO:0000269
name: picolinic acid decarboxylase
reactant: MODEL1310110020#
reversible: false
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (130013.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.45 Confidence Level: 4 AUTHORS: PMID:12140278 NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.1.45
kinetic law: MODEL1310110020#

metaR CITtam
name: citrate transport, mitochondrial
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
type: Reaction
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185

metaM dgtp c
is: HMDB01440
initial concentration: 1.0
name: dGTP
constant: false
is: C00286
has only substance units: false
is: CHEBI:16497
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM HC02210 e
constant: false
is: CHEBI:34939
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
name: prostaglandin-d3
type: Species
has only substance units: false
initial concentration: 1.0

metaR B3GALT5g
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110020#
name: Beta-1,3-galactosyltransferase 5
modifier: MODEL1310110020#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_33488c71_6ca3_44c8_b0ac_cd45d856dece
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM ksi deg36 l
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: HMDB00143
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 36
has only substance units: false

metaM dmhptcrn c
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM hs deg19 l
is: CHEBI:17180
name: heparan sulfate, degradation product 19
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01352
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: SBO:0000247

metaR r2309
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR GLYOX
kinetic law: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.6
reactant: MODEL1310110020#
name: hydroxyacylglutathione hydrolase
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF

metaR r1969
kinetic law: MODEL1310110020#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
is: SBO:0000185

metaM 3ttetddcoa m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02014
name: 3-hydroxy trans5,8tetradecadienoyl coa
constant: false
initial amount: NaN
initial concentration: 1.0

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM dd5ecoa m
is: HMDB13028
is: C01942
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 5-dodecenoylcoa
constant: false
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_41156e87_00e1_4f05_bada_e6b1ee9c7057
initial amount: NaN
name: SULT1A3
initial concentration: NaN
has only substance units: false
is: P50224
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6818

metaR r0388
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR r1755
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
name: Y+LAT2 Utilized transport

metaM glac r
name: D-glucurono-6,3-lactone
is: HMDB06355
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: CHEBI:18268

metaR H2MTer L
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
name: H2 mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

metaM 34hpp c
initial amount: NaN
boundary condition: false
is: HMDB00707
initial concentration: 1.0
is: CHEBI:36242
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: SBO:0000247
constant: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate

metaM odecrn c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01114
is: CHEBI:57394
constant: false
is: C00412
has only substance units: false
name: octadecenoyl carnitine
initial amount: NaN
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR ARGtiDF
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110020#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
name: L-arginine transport via diffusion (extracellular to cytosol)
type: Reaction
is described by: ECO:0000269
fast: false

metaR FBA
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: fructose-bisphosphate aldolase
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is version of: http://identifiers.org/ec-code/4.1.2.13

metaR r1968
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Y+LAT2 Utilized transport
product: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_efc697c2_dec3_44c2_9e59_9433df6c300f
boundary condition: true
is encoded by: hsa:226
initial concentration: NaN
constant: false
is: P04075
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: ALDOA

http://identifiers.org/biomodels.db/MODEL1310110020#_a046fd74_c88d_40f7_aebe_95f4ebbd065f
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC8A3
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6547

metaM dgtp e
initial concentration: 1.0
constant: false
name: dGTP
is: CHEBI:16497
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
boundary condition: false

metaR r0389
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
reversible: true
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12

metaM ksii core2 deg4 l
name: keratan sulfate II (core 2-linked), degradation product 4
is: HMDB00812
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16953
notes: FORMULA: C58H95N5O43SX CHARGE: -1
constant: false
boundary condition: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR LNLNCGCPT2
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110020#
name: carnitine transferase
is: SBO:0000176

metaM 3thexddcoa c
is: HMDB02014
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2855ef39_bbd3_421d_85ac_079db21032cf
is: SBO:0000252
type: Species
is encoded by: hsa:2590
name: GALNT2
has only substance units: false
initial amount: NaN
is: Q10471
initial concentration: NaN
boundary condition: true
constant: false

metaM gluala e
is: HMDB06248
initial concentration: 1.0
name: 5-L-Glutamyl-L-alanine
is: C03740
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6503
has only substance units: false
constant: false

metaR PPD2CSPp
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
type: Reaction
name: PPD2CSPp
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
fast: false

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a06b8261_b011_494b_85d2_bf3ce901f4c4
has only substance units: false
name: NAGK
initial amount: NaN
boundary condition: true
type: Species
is: Q9UJ70
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:55577

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58310
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_38a4d66f_6848_4f19_a2de_165cb64d6457
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q96A70
name: ADC
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:113451

metaR 5OXPROt
kinetic law: MODEL1310110020#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110020#
fast: false
name: Transport of 5-oxoprolinate

http://identifiers.org/biomodels.db/MODEL1310110020#_52c87b65_6a64_4535_bc41_b2e3c6e817da
is: Q92685
initial amount: NaN
name: ALG3
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10195
is: SBO:0000252

metaR CAROtr
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110020#
reversible: true
name: beta-carotene transport via diffusion
fast: false
product: MODEL1310110020#

metaR ITPtn
is described by: ECO:0000000
name: ITP nuclear transport
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110020#

metaR HMGCOARc
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is described by: ECO:0000134
modifier: MODEL1310110020#
type: Reaction

metaR NDPK5n
product: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR PFK26
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.105
kinetic law: MODEL1310110020#
name: 6-phosphofructo-2-kinase

metaM 34hpp m
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00707
initial amount: NaN
type: Species
constant: false

metaR NCNt
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000269
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM ksii core2 e
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
has only substance units: false
type: Species
constant: false
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
is: CHEBI:17268
is: SBO:0000247
boundary condition: false

metaM rbt c
type: Species
is: HMDB00508
boundary condition: false
is: SBO:0000247
name: D-ribitol
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380

http://identifiers.org/biomodels.db/MODEL1310110020#_1520e6c1_40fe_454d_b8a0_25c44a445411
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SLC13A2
has only substance units: false
type: Species
is: E7ETH5
is: SBO:0000252
is encoded by: hsa:9058

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR METtec
is: SBO:0000185
reversible: true
reactant: MODEL1310110020#
name: L-methionine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false

metaR ACCOAtr
is described by: ECO:0000000
product: MODEL1310110020#
is: SBO:0000185
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
reversible: true
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false

metaR ALACYSNaEx
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110020#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110020#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#

metaR FAOXC165C164m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM dcsptn1coa c
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
type: Species
is: SBO:0000247
is: C16173
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483

http://identifiers.org/biomodels.db/MODEL1310110020#_4c366dc4_63a1_4682_9451_603fa5e7235d
name: B4GALT1
is encoded by: hsa:2683
initial amount: NaN
has only substance units: false
is: P15291
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM 3tetd7ecoacrn c
notes: FORMULA: C21H39NO5 CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB02014
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false
has only substance units: false

metaM Lkynr c
initial amount: NaN
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00684
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16946
name: L-kynurenine

http://identifiers.org/biomodels.db/MODEL1310110020#_2d69b1f9_ee1a_440a_99cd_20a1ead0a246
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: PDE5A
is encoded by: hsa:8654
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_aea97810_9618_4cd4_8f0a_c3fc6fbb0ca2
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM ksii core4 pre2 g
has only substance units: false
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1
name: keratan sulfate II boisynthesis, precursor 2
initial amount: NaN
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110020#_466ea59a_9cf9_44c4_af3e_46c96dd83ce6
name: PDE9A
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false

metaR AG13T5g
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_6e24eaa3_aeb9_47ee_9188_7df5c7a592e5
is encoded by: hsa:10558
boundary condition: true
is: SBO:0000252
name: SPTLC1
is: O15269
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR FAOXC226C225x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_bb184277_78ff_4126_833e_10735a3eb7c0
name: RBKS
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:64080
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9H477
boundary condition: true

metaR DESAT18 6
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110020#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reactant: MODEL1310110020#
is: SBO:0000176

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
name: D-ribitol
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15963
is: HMDB00508
type: Species
is: SBO:0000247

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:16443
constant: false
has only substance units: false
type: Species
is: HMDB03418
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II (core 2-linked)
initial amount: NaN
boundary condition: false

metaM adp n
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: ADP(3-)
boundary condition: false
constant: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
type: Species

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: taurochenodeoxycholate
is: CHEBI:9407
is: HMDB00951
type: Species

metaR FAOXC226m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR MMSAD1m
name: methylmalonate-semialdehyde dehydrogenase
type: Reaction
reversible: false
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.27
reactant: MODEL1310110020#

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
boundary condition: false
has only substance units: false
is: HMDB00827
is: CHEBI:25629
initial amount: NaN
name: stearate
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM dhcrm hs c
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:31488
name: dihydroceramide
initial amount: NaN
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

metaM dmhptcrn m
is: HMDB06320
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
constant: false
is: SBO:0000247

metaM 12ppd R c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
name: (R)-propane-1,2-diol
boundary condition: false
initial concentration: 1.0
is: HMDB01881
is: SBO:0000247
type: Species
is: CHEBI:28972
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_1b9d680c_0b75_4f0d_9d3c_c4a8125db448
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC35A1
is: P78382
constant: false
initial concentration: NaN
is encoded by: hsa:10559

http://identifiers.org/biomodels.db/MODEL1310110020#_9566a286_18c6_4cec_ab9b_2b520cc24aad
has only substance units: false
is: Q96NT5
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:113235
constant: false
name: SLC46A1
initial amount: NaN

metaM nrpphr c
is: HMDB00216
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:33569
initial concentration: 1.0
initial amount: NaN
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaR FAOXC16C16OHm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaR DESAT18 4
is: SBO:0000176
modifier: MODEL1310110020#
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_22ad77aa_196b_409c_be1b_da7ac1ea9d07
initial amount: NaN
boundary condition: true
is: P22303
initial concentration: NaN
is: SBO:0000252
name: ACHE
constant: false
has only substance units: false
type: Species
is encoded by: hsa:43

metaM adp m
initial amount: NaN
constant: false
boundary condition: false
is: C00008
type: Species
has only substance units: false
name: ADP
is: CHEBI:456216
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341

metaM cdpea c
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
type: Species
name: cdpea[c]
is: CHEBI:57876
boundary condition: false
initial amount: NaN
is: HMDB01564
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaR GLCNACT L
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
fast: false
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
kinetic law: MODEL1310110020#
reversible: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f1ff7dbc_d52a_49f2_8e64_8007e8886570
boundary condition: true
is encoded by: hsa:6482
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: ST3GAL1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_db10348e_5da8_41a5_a10b_67ad706ce610
boundary condition: true
name: DCXR
initial amount: NaN
is: Q7Z4W1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:51181

metaM ac c
type: Species
name: acetate
boundary condition: false
has only substance units: false
constant: false
is: HMDB00042
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: CHEBI:30089

metaM 3tetd7ecoacrn e
initial amount: NaN
type: Species
notes: FORMULA: C21H39NO5 CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB02014
initial concentration: 1.0
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d6aa036f_c1a2_443b_ac60_b426d45df2ee
boundary condition: true
constant: false
name: GUCY1B2:GUCY1A3
is: SBO:0000297
is encoded by: hsa:2982
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
has part: D6RDW3
is encoded by: hsa:2974

metaM HC01405 m
type: Species
initial amount: NaN
is: CHEBI:28632
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial concentration: 1.0
boundary condition: false
name: (S)-Hydroxyoctanoyl-CoA
is: SBO:0000247
constant: false
has only substance units: false

metaR OLEICFATPtc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_df8f3c35_f477_47c2_81b0_6d290fdd05e1
is encoded by: hsa:284111
constant: false
initial amount: NaN
is: Q86YT5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: SLC13A5

metaR S2TASE2ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD

metaM didp n
type: Species
name: dIDP
has only substance units: false
initial concentration: 1.0
is: HMDB03536
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
is: CHEBI:28823
initial amount: NaN
boundary condition: false

metaR 4NPHSULT
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: 4-Nitrophenol Sulfotransferase
product: MODEL1310110020#
is: SBO:0000176

metaR FAOXTC122m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2b8fa528_eece_4ec3_8adf_a8b4de0e17a6
is encoded by: hsa:4719
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NDUFS1
is: P28331
initial concentration: NaN

metaR SCP22x
is: SBO:0000185
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110020#

metaM hpdcacoa m
is: HMDB06497
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
type: Species
name: heptadecanoyl coa
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

metaM nrpphr e
constant: false
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
has only substance units: false
is: CHEBI:33569
initial amount: NaN
boundary condition: false
name: Norepinephrine
initial concentration: 1.0
type: Species

metaM udp r
constant: false
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: C00015
is: HMDB00295
name: UDP
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR ACCOAtn
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: acetyl-CoA transport, nuclear
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_0dccc646_597b_4f36_b955_2bcfb1092972
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2876
type: Species
initial amount: NaN
has only substance units: false
name: GPX1

metaR PSP L
is: SBO:0000176
type: Reaction
name: phosphoserine phosphatase (L-serine)
fast: false
reactant: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.3
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR EX tolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tolbutamide exchange
type: Reaction

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR DUMPtn
type: Reaction
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_190fee87_9257_4dd0_8298_244bec6350d8
initial concentration: NaN
is encoded by: hsa:51022
boundary condition: true
has only substance units: false
name: GLRX2
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_25cbccf0_3f5e_486e_984b_5f11556e5ab2
is encoded by: hsa:5305
is: P48426
is: SBO:0000252
name: PIP4K2A
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR RE1691M
type: Reaction
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.1
reversible: true
name: RE1691
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f710b8d8_5226_462e_9fc3_4ad48565af0e
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: SLC4A9
is encoded by: hsa:83697
is: E9PDK1
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR CRNCAR3tp
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
name: carnitine-propcarnitine carrier, peroxisomal

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaM ac e
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00042
name: acetate
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: CHEBI:30089

metaR 5ADTSTSTERONEtr
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110020#
fast: false
type: Reaction
name: 5 alpha dihydrotesterone intracellular transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110020#

metaM adp r
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
name: ADP(3-)
is: HMDB01341
is: SBO:0000247
boundary condition: false
is: CHEBI:456216
initial amount: NaN
initial concentration: 1.0
constant: false

metaR FATP3t
name: fatty acid electroneutral transport
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false
type: Reaction

metaR ATP2ter
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000

metaR FADtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
name: FAD transporter, peroxisomal
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_ec4125bc_f59c_49f2_ad6b_64892a55f440
constant: false
is encoded by: hsa:384
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P78540
type: Species
name: ARG2
initial concentration: NaN

metaM amp x
has only substance units: false
type: Species
name: AMP
constant: false
is: HMDB00045
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
boundary condition: false
is: C00020
initial concentration: 1.0
initial amount: NaN

metaR AMCOXO
product: MODEL1310110020#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110020#
name: 2-aminomuconate reductase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:not sure about name NCD
reactant: MODEL1310110020#
type: Reaction

metaM 3ttetddcoa c
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB02014
boundary condition: false
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
constant: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaR DCSPTN1t
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR HSD17B42x
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reactant: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110020#

metaR DOLMANP Lter
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
name: dolichol-phosphate mannose flippase (liver)

http://identifiers.org/biomodels.db/MODEL1310110020#_294c7581_c261_49f5_9850_67d852491e1a
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8789
is: O00757
constant: false
name: FBP2
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_f2e0835b_6bfc_49d8_9265_2c712fbd5698
name: ISYNA1
initial concentration: NaN
constant: false
initial amount: NaN
is: B3KRT1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:51477
is: SBO:0000252

metaR FACOAL150
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is described by: ECO:0000000
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: fatty-acid--CoA ligase
type: Reaction

metaM c8dc x
name: suberyl carnitine
is: HMDB00893
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

metaR r0246
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#

metaR DIDPtn
fast: false
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185
name: dIDP nuclear transport
is described by: ECO:0000000
product: MODEL1310110020#

metaR CYSGLTH
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
name: Glutathione:cystine oxidoreductase
reversible: true

metaM ru5p D c
is: HMDB00618
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
constant: false
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)

metaM cmpacna g
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
is: HMDB01176
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaR RE3346C
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false
name: RE3346
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM udp n
is: CHEBI:58223
name: UDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
constant: false
type: Species
is: HMDB00295
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM pro D e
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB03411
name: D-proline
is: SBO:0000247

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
constant: false
is: CHEBI:58190
is: HMDB00224
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaM clpndcoa c
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205476
is: C16166
type: Species
is: HMDB06267
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: clupanodonyl CoA

metaR MALtm
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
reactant: MODEL1310110020#
name: malate transport, mitochondrial
is described by: ECO:0000269
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_fa415565_00a5_40d3_b54f_3bb1c26f8356
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84105
initial concentration: NaN
type: Species
name: PCBD2
boundary condition: true
constant: false
is: Q9H0N5

metaR r0245
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110020#_ff79725a_bae6_4770_9418_5156da0065c9
constant: false
type: Species
is: SBO:0000252
is: Q9NYW8
is encoded by: hsa:57786
initial amount: NaN
name: RBAK
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM fe3 e
type: Species
is: CHEBI:29034
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB12943
name: Fe3+
initial concentration: 1.0
boundary condition: false

metaR SERASNNaEx
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
fast: false
product: MODEL1310110020#

metaR M4MPDOL Lter
name: m4mpdol flippase
kinetic law: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185

metaM tethex3 e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: HMDB02007
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_8d1e7cd9_7497_459b_9c41_e1029beaf05d
has only substance units: false
is encoded by: hsa:5277
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:8818
type: Species
has part: P37287
initial concentration: NaN
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaR GLCAASE7ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
name: beta-glucuronidase, lysosomal
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR PTE3x
modifier: MODEL1310110020#
type: Reaction
name: peroxisomal acyl-CoA thioesterase
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ

metaR FAOXC183806m
is described by: ECO:0000269
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM HC00591 c
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16769
constant: false
name: 2-oxoglutaramate

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR S6TASE23ly
product: MODEL1310110020#
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110020#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_ca616f50_99ad_4383_bb4c_d2830b80a65e
has only substance units: false
initial concentration: NaN
is: A0PJK1
constant: false
is encoded by: hsa:125206
type: Species
is: SBO:0000252
boundary condition: true
name: SLC5A10
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_67d8392d_b89a_4246_b344_9ab69add8615
type: Species
is: P51688
name: SGSH
boundary condition: true
is encoded by: hsa:6448
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0139
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR G14T4g
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM adpac c
initial amount: NaN
constant: false
is: HMDB00448
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: adipic acid
notes: FORMULA: C6H8O4 CHARGE: -2

metaR GGT6
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
name: Gamma-glutamyltransferase
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176

metaM 3ivcrn c
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C12H23NO5 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
is: HMDB06870
is: C05998

metaM udp l
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247
name: UDP(3-)
initial amount: NaN
is: HMDB00295

metaR S3TASE2ly
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110020#_6b0a7f61_e98a_4ed8_a6a4_f9e171a86c1f
is: P25705
constant: false
boundary condition: true
is encoded by: hsa:498
name: ATP5A1
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM cit m
name: Citrate
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: C00158
has only substance units: false
type: Species
is: HMDB00094
is: SBO:0000247
boundary condition: false
is: CHEBI:16947
constant: false

metaM 2maacoa m
has only substance units: false
is: HMDB01157
type: Species
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57335
initial amount: NaN
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344

metaM tddedicoa m
type: Species
constant: false
name: trans3,6dodecadienoylcoa
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM fe3 c
type: Species
notes: FORMULA: Fe CHARGE: 3
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: Fe3+
initial concentration: 1.0
boundary condition: false
is: HMDB12943

metaM h2o2 m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
initial amount: NaN
name: Hydrogen peroxide
boundary condition: false
constant: false
is: C00027
is: HMDB03125

metaR T4HCINNMFM
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
type: Reaction
reversible: false
name: 4-hydroxycinnamate formation

http://identifiers.org/biomodels.db/MODEL1310110020#_d9adcc94_e648_4bb7_b82b_dad65f4ecd93
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: Q14435
name: GALNT3
is encoded by: hsa:2591
type: Species
boundary condition: true

metaM pro D c
is: CHEBI:16313
initial concentration: 1.0
boundary condition: false
name: D-proline
is: HMDB03411
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_a2eb0cb2_fefe_41c7_93e9_07dd51d8e1f6
is encoded by: hsa:23530
boundary condition: true
initial amount: NaN
name: NNT
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q13423

http://identifiers.org/biomodels.db/MODEL1310110020#_fe4f93c0_0f93_4516_b2aa_68d2a5ab2ea8
type: Species
is encoded by: hsa:84720
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PIGO

metaR r1619
is described by: ECO:0000000
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110020#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM gullac r
is: SBO:0000247
initial concentration: 1.0
name: L-gulono-1,4-lactone
type: Species
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: HMDB03466
is: CHEBI:17587
initial amount: NaN
boundary condition: false
constant: false

metaR ALAtN1
reversible: true
kinetic law: MODEL1310110020#
name: Alanine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
product: MODEL1310110020#
is described by: ECO:0000269

metaM pro L e
is: HMDB00162
boundary condition: false
name: L-proline
is: SBO:0000247
type: Species
is: CHEBI:17203
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
initial amount: NaN
has only substance units: false

metaM spc hs c
boundary condition: false
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC163x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaM amp r
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: AMP
is: HMDB00045
is: CHEBI:456215
boundary condition: false
initial amount: NaN
is: C00020

http://identifiers.org/biomodels.db/MODEL1310110020#_5205f35d_3bbb_4e0c_b484_8eaeb77a068d
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: ADSL
is encoded by: hsa:158

http://identifiers.org/biomodels.db/MODEL1310110020#_29bdc4f4_544c_4a38_bc45_c9fcf88366df
initial amount: NaN
has only substance units: false
name: TXNRD1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:7296

metaR r0242
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#

metaR TAURCHAe
reactant: MODEL1310110020#
product: MODEL1310110020#
name: exit of taurine from the enterocytes
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110020#
reversible: false

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM 3ivcrn e
name: 3-hydroxy-isovaleryl carnitine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C12H23NO5 CHARGE: 0
is: SBO:0000247
is: HMDB13336

metaM atp c
is: SBO:0000247
is: HMDB00538
is: CHEBI:30616
type: Species
has only substance units: false
boundary condition: false
constant: false
name: ATP(4-)
initial concentration: 1.0
initial amount: NaN
is: C00002

metaM ocdca e
initial concentration: 1.0
initial amount: NaN
is: HMDB00827
has only substance units: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
constant: false
is: CHEBI:25629
name: octadecanoate (n-C18:0)
boundary condition: false
is: SBO:0000247
is: C01530

http://identifiers.org/biomodels.db/MODEL1310110020#_a766b156_2697_4403_86cf_417fde5deca4
type: Species
is encoded by: hsa:93010
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: B3GNT7
is: SBO:0000252
is: Q8NFL0
initial concentration: NaN

metaM asp L m
is: CHEBI:29991
initial concentration: 1.0
is: HMDB00191
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: L-aspartate(1-)

metaM adp x
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
is: CHEBI:456216
name: ADP(3-)

metaR GAL3ST11
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.11
fast: false
reversible: false
name: Galactosylceramide sulfotransferase
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM L2aadp c
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
is: HMDB00510
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58672
constant: false

metaM urcan c
is: C00785
type: Species
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00301
is: CHEBI:17771
has only substance units: false
is: SBO:0000247

metaR r2027
modifier: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a90bcf10_7ea2_449e_8729_5a06fe69fda4
name: ABCC5
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:10057
boundary condition: true
constant: false
is: SBO:0000252

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM pro L c
name: L-proline
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17203
constant: false
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
initial concentration: 1.0

metaR NDP3ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
type: Reaction
fast: false
reversible: false
name: nucleoside-diphosphatase (GDP), extracellular

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_772efdf3_a849_4ff4_abfe_dfa13d98af9e
is encoded by: hsa:9551
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: Q6IBB3
name: ATP5J2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_89f38ab7_d6b1_49e7_8ffc_365cf274f469
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7083
boundary condition: true
constant: false
has only substance units: false
is: P04183
name: TK1
initial concentration: NaN

metaR RE3367E
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
is: SBO:0000176
name: RE3367
fast: false
product: MODEL1310110020#
reversible: false

metaM spc hs e
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110020#
modifier: MODEL1310110020#

metaM atp e
name: ATP(4-)
is: HMDB00538
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57299
is: C00002
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_bf8053d0_baae_4a6e_8bc3_1f7cd48361ff
boundary condition: true
has only substance units: false
type: Species
name: PLCB4
is: E2QRH8
is: SBO:0000252
is encoded by: hsa:5332
constant: false
initial amount: NaN
initial concentration: NaN

metaM ac m
name: acetate
is: CHEBI:30089
is: HMDB00042
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
type: Species
constant: false

metaM tethex3 c
initial amount: NaN
name: tetracosahexaenoic acid, n-3
type: Species
constant: false
is: HMDB02007
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaR FBP
is version of: http://identifiers.org/ec-code/3.1.3.11
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
name: fructose-bisphosphatase
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176

metaR NAGLCAly
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosaminidase, lysosomal
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
fast: false

metaM trdrd m
boundary condition: false
is: SBO:0000247
type: Species
name: Reduced thioredoxin
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR HSD3B7P
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_4d7868d7_a10c_4ab1_9967_0e0def1ba07c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: GUCY1B3
is: Q02153
is encoded by: hsa:2983
initial concentration: NaN
constant: false

metaM accoa g
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57288
boundary condition: false
name: acetyl-CoA(4-)
is: HMDB01206
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_46f8bf03_ec4a_490e_a75f_1c581940b679
is encoded by: hsa:5279
boundary condition: true
has part: Q92535
initial concentration: NaN
is encoded by: hsa:8818
is encoded by: hsa:51227
type: Species
is encoded by: hsa:9091
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
is encoded by: hsa:5277
is encoded by: hsa:5283
has part: O94777
has part: Q14442
has part: Q9BRB3
has part: B3KUV7

http://identifiers.org/biomodels.db/MODEL1310110020#_96829af1_8ac1_423f_a4c9_7f6e4d0afe66
is encoded by: hsa:91703
is: Q96HD9
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: ACY3
type: Species
initial amount: NaN

metaM hs deg20 l
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00127
constant: false
is: CHEBI:15748
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 20
initial concentration: 1.0
notes: FORMULA: C45H68N2O43S2 CHARGE: -4

metaR S4TASE4ly
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176

metaM nrvnc c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
constant: false
boundary condition: false
name: nervonate
is: CHEBI:32392
initial concentration: 1.0
is: SBO:0000247
is: HMDB02368

http://identifiers.org/biomodels.db/MODEL1310110020#_0c98235d_f0e1_40bb_9a87_c732015de44c
name: AMPD1
is encoded by: hsa:270
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: P23109
has only substance units: false

metaR CYANt
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110020#
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
fast: false
is described by: ECO:0000000

metaR RE0577C
kinetic law: MODEL1310110020#
reversible: true
name: RE0577
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4946e72b_bd6f_402a_b5f8_a1250226d5ae
initial amount: NaN
is: P23378
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: GLDC
is: SBO:0000252
is encoded by: hsa:2731

metaR FACOAL140i
reversible: false
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
name: fatty-acid--CoA ligase (tetradecanoate)

metaR r1744
reversible: false
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110020#

metaM udp e
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
is: HMDB00295
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
is: SBO:0000247
constant: false
type: Species
has only substance units: false

metaR r1615
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110020#
reversible: true

metaR GLYC St
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110020#
name: L-glycerate export

metaM udp g
constant: false
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00295
is: CHEBI:58223
has only substance units: false
initial concentration: 1.0

metaM inost e
constant: false
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
is: CHEBI:17268
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_7736834a_444b_40b0_9a3b_3e20c4b72521
boundary condition: true
has only substance units: false
is encoded by: hsa:2650
type: Species
is: SBO:0000252
initial amount: NaN
is: Q02742
name: GCNT1
constant: false
initial concentration: NaN

metaR DOLPMT2 Ler
kinetic law: MODEL1310110020#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176

metaM amp m
boundary condition: false
type: Species
constant: false
name: AMP(2-)
is: HMDB00045
is: CHEBI:456215
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM glac c
initial amount: NaN
type: Species
is: CHEBI:18268
has only substance units: false
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
name: D-glucurono-6,3-lactone
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM hexdpencoa x
name: 2,4,7,10,13-hexadecapentaenoylcoa
boundary condition: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110020#_44a8447f_61bd_4157_b0c0_75166e27f0f1
is encoded by: hsa:5264
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O14832
type: Species
name: PHYH
has only substance units: false

metaR r1616
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_409a8467_1fdc_4f17_94db_84a0f16de2c7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5335
constant: false
is: SBO:0000252
name: PLCG1
type: Species
boundary condition: true
is: Q9UFY1
has only substance units: false

metaM CE5117 m
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
is: CHEBI:57923
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
name: dCDP(3-)
initial amount: NaN
boundary condition: false
is: HMDB01245
constant: false
is: SBO:0000247
is: CHEBI:58593
initial concentration: 1.0
has only substance units: false

metaM hista c
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: histamium
is: CHEBI:58432
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_17d2488c_0531_490e_a214_255c96236cbe
type: Species
initial concentration: NaN
is: P55084
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3032
initial amount: NaN
constant: false
name: HADHB

metaR r0809
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Facilitated diffusion
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110020#
fast: false
type: Reaction
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_7200fd66_a730_4d6f_81bc_b5f640434cf2
constant: false
is encoded by: hsa:2109
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P38117
name: ETFB
initial concentration: NaN
boundary condition: true
type: Species

metaM phytcoa c
type: Species
boundary condition: false
name: phytanoyl-CoA(4-)
initial amount: NaN
is: HMDB01359
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: SBO:0000247
constant: false
is: CHEBI:57391

metaR NACHEX26ly
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM atp r
boundary condition: false
is: HMDB00538
type: Species
initial amount: NaN
is: C00002
is: CHEBI:57299
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: ATP(4-)

metaM dcdp n
has only substance units: false
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
type: Species
constant: false
name: dCDP(3-)
boundary condition: false
initial amount: NaN
is: HMDB01245
is: SBO:0000247

metaR r1617
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000000

metaM udp c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: HMDB00295
name: UDP
is: C00015
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaR HSD3A1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
modifier: MODEL1310110020#
product: MODEL1310110020#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
reversible: true
reactant: MODEL1310110020#

metaM didp c
type: Species
is: HMDB03536
initial amount: NaN
constant: false
name: dIDP
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
has only substance units: false
is: CHEBI:28823

http://identifiers.org/biomodels.db/MODEL1310110020#_1516a752_e083_4fe6_864e_eac7268919b5
type: Species
is encoded by: hsa:AA614647
has only substance units: false
name: _AA614647_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00257
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
boundary condition: false
is: CHEBI:16094
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00094
constant: false
is: CHEBI:16947
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: citrate(3-)

metaR r0130
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110020#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c28fb652_b1f7_4746_9145_85c58194fca6
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: DHCR24
has only substance units: false
is: Q15392
is: SBO:0000252
is encoded by: hsa:1718

metaR ABTArm
modifier: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
fast: false

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2a9b66ce_2fbb_4bf0_9489_165a7b29802c
name: CPS1
is: B7ZAW0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1373
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#

metaR PDX5PO
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: pyridoxine 5'-phosphate oxidase
is described by: ECO:0000269
reversible: true
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_49884a52_b3bb_4e23_be56_bb708e942672
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AA502753_1_m
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AA502753

http://identifiers.org/biomodels.db/MODEL1310110020#_f32a55af_d25c_4217_90f1_6dccee8d363b
has only substance units: false
boundary condition: true
is encoded by: hsa:AA664770
initial concentration: NaN
name: _AA664770_1_m
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_258c8c01_812a_4c96_9ad0_e4b796865c3e
constant: false
is: Q9NY59
initial amount: NaN
is encoded by: hsa:55512
name: SMPD3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR GMPR
is described by: ECO:0000269
kinetic law: MODEL1310110020#
name: GMP reductase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.7.1.7
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
reversible: false

metaM hista e
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00870
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
has only substance units: false
name: histamium

http://identifiers.org/biomodels.db/MODEL1310110020#_e0492038_e5c4_4a79_aa76_a1712f3f0573
is encoded by: hsa:6579
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: SLCO1A2
is: SBO:0000252
has only substance units: false
is: P46721
initial concentration: NaN

metaM ksi pre29 g
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:28067

metaM cmpacna c
is: HMDB01176
type: Species
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaM h2o2 x
is: C00027
is: CHEBI:16240
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
type: Species
boundary condition: false
name: Hydrogen peroxide
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM 3thexddcoa m
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
is: HMDB02014
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_0160d507_7221_46dc_9d80_6f32a79e6483
is: SBO:0000252
type: Species
name: CHKB
initial concentration: NaN
is encoded by: hsa:1120
initial amount: NaN
constant: false
boundary condition: true
is: A0PJM6
has only substance units: false

metaM 4h2oglt m
initial amount: NaN
has only substance units: false
is: HMDB02070
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17742
name: 4-hydroxy-2-oxoglutarate(2-)

metaR DGTPtn
reactant: MODEL1310110020#
product: MODEL1310110020#
name: dGTP diffusion in nucleus
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reversible: true
fast: false

metaM sgalside hs c
initial amount: NaN
constant: false
type: Species
name: sulfatide galactocerebroside
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: HMDB03406
is: CHEBI:16523

metaM ttdca c
is: HMDB00806
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
initial amount: NaN
has only substance units: false
name: myristate
is: CHEBI:30807
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7bb3fe5d_d2a9_4e8b_88e0_078d2a47ca00
initial amount: NaN
is: Q9BY07
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC4A5
constant: false
type: Species
boundary condition: true
is encoded by: hsa:57835

metaR 5ADTSTSTERONEte
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: 5 alpha dihydrotesterone transport
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: true

metaR r1748
kinetic law: MODEL1310110020#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
reversible: false
fast: false
product: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#

metaM accoa c
name: Acetyl-CoA
is: SBO:0000247
is: HMDB01206
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
constant: false
is: CHEBI:57288
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1611
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#

metaM cit c
is: CHEBI:16947
is: C00158
name: Citrate
is: SBO:0000247
is: HMDB00094
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
boundary condition: false

metaM pro L m
is: CHEBI:17203
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
is: HMDB00162
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: L-proline
constant: false

metaM ksi deg34 l
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00812
type: Species
name: keratan sulfate I, degradation product 34
is: CHEBI:16953
initial concentration: 1.0

metaR GTMLTe
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
name: g-glutamyltransferase (e)
modifier: MODEL1310110020#
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction

metaM mi145p c
has only substance units: false
is: HMDB01498
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
boundary condition: false
is: CHEBI:203600
initial concentration: 1.0

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
name: sphingosine kinase 2
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
is described by: ECO:0000269
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_f5be2f87_5f39_43d4_83c8_4db2464888b9
name: DGKZ
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8525
is: B7Z6M3
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_b58beba5_55d2_4c76_8a6e_7d620afa5626
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: PDE5A
initial amount: NaN
is encoded by: hsa:8654
is: O76074
initial concentration: NaN
has only substance units: false

metaM dolp L c
is: SBO:0000247
constant: false
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_59a854c4_08dc_4175_8bb3_437f22d0643f
name: B3GALNT1
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:8706
constant: false
is: SBO:0000252
is: Q8TDY1

metaR HIBDm
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
product: MODEL1310110020#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176

metaR NACHEX14ly
type: Reaction
modifier: MODEL1310110020#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR FAOXC5C3x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR SMS
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
name: Sphingomyelin synthase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.27

metaR r0249
kinetic law: MODEL1310110020#
reversible: true
type: Reaction
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is version of: http://identifiers.org/ec-code/2.7.7.12

metaR r1612
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PYNP2r
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: true
modifier: MODEL1310110020#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2

metaR r0381
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reversible: true
fast: false

metaR ALAGLNNaEx
reversible: false
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
type: Reaction
product: MODEL1310110020#

metaM HC01231 m
initial amount: NaN
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
is: CHEBI:58480
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4f7170cf_37ff_400e_bd4d_247078110724
constant: false
initial amount: NaN
is: Q5SPY7
has only substance units: false
boundary condition: true
type: Species
name: ENTPD2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:954

metaR RE2972M
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
name: RE2972
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_695ab5f6_dbe0_41d8_9466_1a54f3474f5c
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6342
is: SBO:0000252
is: C9JC79
boundary condition: true
name: SCP2
type: Species
initial amount: NaN

metaM nrvnc e
is: CHEBI:32392
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: HMDB02368
initial concentration: 1.0
name: nervonate
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false

metaR FAOXC225x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM atp n
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00538
has only substance units: false
initial amount: NaN
is: CHEBI:57299

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM dcsptn1coa m
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513

metaM tmndnccoa x
type: Species
constant: false
initial concentration: 1.0
name: timnodonyl coenzyme A
is: HMDB06514
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
initial amount: NaN

metaR r1613
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction

metaR RTOTAL2FATPc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR RE3005M
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
name: RE3005
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

metaM prostgi2 r
type: Species
is: HMDB01335
is: CHEBI:57403
has only substance units: false
name: prostaglandin I2(1-)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_4fae6463_e6e7_4303_a8c1_60c1aa81d364
is: Q01415
has only substance units: false
initial concentration: NaN
name: GALK2
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2585
is: SBO:0000252

metaM inost c
has only substance units: false
initial amount: NaN
name: myo-inositol
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17268
constant: false
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false

metaR FAOXC80
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_39de40c9_f7db_48d6_ae72_c0df8cf8d730
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8228
name: PNPLA4
constant: false
is: P41247
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_6e2a8966_e76f_4f21_9cef_54914584dd48
is encoded by: hsa:445
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: ASS1
is: Q5T6L4

metaM atp m
is: CHEBI:57299
initial concentration: 1.0
is: HMDB00538
type: Species
is: C00002
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: ATP(4-)

metaM ttdca e
initial amount: NaN
is: HMDB00806
is: CHEBI:30807
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: C06424
name: tetradecanoate (n-C14:0)

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true

metaR PRISTtx
is described by: ECO:0000000
name: prist peroxisomal transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c8edef11_a306_430c_b1be_bf11dda1b81d
boundary condition: true
is: Q9NUB1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:84532
name: ACSS1
constant: false

metaM amuco c
initial concentration: 1.0
type: Species
is: HMDB01241
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C6H6NO4 CHARGE: -1 INCHI: InChI=1S/C6H7NO4/c7-4(6(10)11)2-1-3-5(8)9/h1-3H,7H2,(H,8,9)(H,10,11)/p-2/b3-1+,4-2- HEPATONET_1.0_ABBREVIATION: HC00907
has only substance units: false
name: 2-aminomuconate(2-)
is: CHEBI:57937

metaR FAOXC61C4m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM eitetcoa m
type: Species
is: http://identifiers.org/pubchem.compound/24892790
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
constant: false

metaR HPDCACRNCPT2
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: heptadecanoate transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
fast: false
product: MODEL1310110020#

metaR CYTK3n
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR CSPG Atly
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
reversible: false
reactant: MODEL1310110020#

metaR ITCOAL1m
fast: false
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
is described by: ECO:0000304
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
modifier: MODEL1310110020#

metaM dag hs c
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: diglyceride
boundary condition: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaM hs deg4 l
is: HMDB00127
has only substance units: false
name: heparan sulfate, degradation product 4
boundary condition: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
type: Species
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR ECOAH12m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is described by: ECO:0000304
modifier: MODEL1310110020#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4703f442_ba22_4cd6_a322_78399b8968a1
initial concentration: NaN
name: PIP4K2C
initial amount: NaN
constant: false
is encoded by: hsa:79837
is: SBO:0000252
type: Species
boundary condition: true
is: B3KQV3
has only substance units: false

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR CLPNDt
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110020#
reversible: true

metaR OCD11CRNCACT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR FAOXC163GC142m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM fuc L c
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: L-fucose
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_68ce33b2_33b4_490c_bd3c_4f707901d46e
boundary condition: true
initial amount: NaN
is: Q96PD7
is encoded by: hsa:84649
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: DGAT2
type: Species

metaR RE1796R
modifier: MODEL1310110020#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
kinetic law: MODEL1310110020#
name: RE1796
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
modifier: MODEL1310110020#
name: Beta oxidation of long chain fatty acid
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM ksii core2 deg3 l
is: SBO:0000247
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false
is: CHEBI:12936
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2

metaR HPDCACRNCPT1
name: carnitine fatty-acyl transferase
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR PROSTGE2t2
kinetic law: MODEL1310110020#
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110020#
name: prostaglandin uniport
type: Reaction
is: SBO:0000185

metaM CE2422 m
has only substance units: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: CHEBI:28387
initial concentration: 1.0
is: HMDB11123
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

metaR DUDPtn
is described by: ECO:0000000
kinetic law: MODEL1310110020#
type: Reaction
fast: false
reactant: MODEL1310110020#
reversible: true
is: SBO:0000185
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1f81935d_ea99_4fe8_b0b4_9f282bdd16af
initial concentration: NaN
has only substance units: false
has part: P08195
has part: Q9NS82
is encoded by: hsa:6520
is: SBO:0000297
is encoded by: hsa:56301
constant: false
type: Species
initial amount: NaN
name: SLC7A10:SLC3A2
boundary condition: true

metaR C10DCCACT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Linoleyl carnitine
is: HMDB06469

metaR HPDCAt
name: fatty acid transport via diffusion
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaR MG1er
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.106
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
modifier: MODEL1310110020#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_d56e222e_b500_421a_9d66_a735f8706582
name: ACAD10
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80724
is: G3XAJ0
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR FMNALKPle
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false
name: FMNALKPle
reversible: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_e2e41d20_2f76_46e3_b1d4_bc3ee40f2629
type: Species
constant: false
is encoded by: hsa:3099
boundary condition: true
initial concentration: NaN
name: HK2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P52789

metaR P450SCC1m
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
kinetic law: MODEL1310110020#
reversible: true
name: cholesterol monooxygenase
product: MODEL1310110020#
is described by: ECO:0000134
fast: false
is: SBO:0000176
type: Reaction

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: beta-galactosidase, lysosomal

metaR FAOXC140
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110020#
name: Beta oxidation of long chain fatty acid
fast: false
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
modifier: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1318f2aa_beee_4839_b6bf_ff33d2ca23de
name: DGKQ
initial amount: NaN
is: P52824
initial concentration: NaN
is encoded by: hsa:1609
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_9cd9b0b3_65b7_4dd0_8823_e6309c09377d
name: ATP10A
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57194
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: O60312

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
name: Choline transport, nuclear through pores
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR ABO5g
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
modifier: MODEL1310110020#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110020#

metaR B3GNT35g
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110020#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110020#
fast: false

metaM 3aib m
name: (S)-3-aminoisobutyric acid
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:33094
boundary condition: false
initial amount: NaN
is: HMDB02166
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c0e4b8ae_e5de_4283_b6cc_eb2195f57439
is: P09923
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:248
constant: false
type: Species
name: ALPI

metaM dag hs e
is: CHEBI:18035
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
type: Species
name: diglyceride
has only substance units: false

metaR 4MTOLBUTAMIDEte
name: xenobiotic transport
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
product: MODEL1310110020#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false

metaM pi x
is: SBO:0000247
is: HMDB00973
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:43474
initial amount: NaN
name: hydrogenphosphate
has only substance units: false

metaM tyr L m
boundary condition: false
type: Species
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00158
initial concentration: 1.0
constant: false

metaR FAOXC14C12m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_f48487ad_c9ae_4b9a_a69b_58ba862238e4
is encoded by: hsa:55361
is: Q9BTU6
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PI4K2A
boundary condition: true

metaM arachdcrn c
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57387
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
name: C20:4 carnitine
is: SBO:0000247
is: HMDB01322
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_db5fc588_4e5b_4590_bc29_4878975a8088
is encoded by: hsa:122622
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8N142
initial amount: NaN
has only substance units: false
name: ADSSL1

http://identifiers.org/biomodels.db/MODEL1310110020#_c2079953_5c6c_4687_ab72_8245ecf73e55
type: Species
initial concentration: NaN
has only substance units: false
name: PDE6C
is: SBO:0000252
is encoded by: hsa:5146
is: P51160
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b6fdc357_b0eb_4d1d_9725_de55aaca7ed3
is: Q9NPB1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:56953
name: NT5M

metaR AG13T11g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_7b109f9d_c732_43b7_8ade_64bb7372256d
is encoded by: hsa:10632
type: Species
is: SBO:0000252
has only substance units: false
is: O75964
initial amount: NaN
constant: false
boundary condition: true
name: ATP5L
initial concentration: NaN

metaR r0926
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
name: Postulated transport reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a42b8f7d_3822_42d9_b0c5_486fafa12f6b
is: SBO:0000252
is encoded by: hsa:22978
boundary condition: true
is: P49902
constant: false
type: Species
name: NT5C2
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2a513190_73f6_4b51_b5af_91c903b8e2a8
is: P48200
type: Species
is encoded by: hsa:3658
has only substance units: false
constant: false
name: IREB2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_59ea7126_1e97_44c8_a093_62bc595e190f
constant: false
is encoded by: hsa:5167
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: ENPP1
has only substance units: false
is: SBO:0000252
is: P22413

metaR DHFR
name: dihydrofolate reductase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

metaM acac e
name: acetoacetate
initial amount: NaN
initial concentration: 1.0
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaM n2m2nm l
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial amount: NaN
boundary condition: false
is: HMDB00573
constant: false
name: n2m2nmasn (w/o peptide linkage)
has only substance units: false
type: Species
is: CHEBI:30825
is: SBO:0000247
initial concentration: 1.0

metaR r2359
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM hpdca c
is: SBO:0000247
has only substance units: false
is: HMDB02259
is: CHEBI:32366
boundary condition: false
name: margarate
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial concentration: 1.0

metaR r1851
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
fast: false
name: Y+LAT2 Utilized transport

metaR CSND
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
name: Cytosine deaminase
kinetic law: MODEL1310110020#

metaR MMEm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.99.1
fast: false
modifier: MODEL1310110020#
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
kinetic law: MODEL1310110020#
is described by: ECO:0000269
name: methylmalonyl-CoA epimerase/racemase

metaR H2Otg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185

metaR r2018
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
product: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: Choline uniport

metaM core6 g
type: Species
initial concentration: 1.0
name: Core 6
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16478
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false

metaR SERGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_5ab38e41_fca2_403a_bd07_3fe5865d4317
is encoded by: hsa:8704
name: B4GALT2
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR r2358
kinetic law: MODEL1310110020#
reversible: true
fast: false
product: MODEL1310110020#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110020#

metaM eicostetcoa m
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
type: Species
is: C16164
boundary condition: false
name: eicosatetranoyl coenzyme A

metaM tettet6 c
is: SBO:0000247
is: HMDB06246
type: Species
constant: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: tetracosatetraenoic acid n-6

metaR GMAND
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.47
is described by: ECO:0000000
name: GDP-D-mannose dehydratase
reversible: false
reactant: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176
product: MODEL1310110020#

metaM 3mlda c
name: 3-Methylimidazoleacetic acid
is: C05828
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/8122
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02820
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
boundary condition: false

metaR C2tcx
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR r0013
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
fast: false

metaR DHDPBMTm
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
name: dihydroxydecaprenylbenzoate methyltransferase
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is version of: http://identifiers.org/ec-code/2.1.1.114
is described by: ECO:0000269
fast: false

metaR TSTSTERONEt
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
name: Testosterone transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false

metaR DDECCRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_5d40b497_79c7_42aa_9f5a_e9868456daa9
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC27A2
is encoded by: hsa:11001
is: O14975
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM prist x
boundary condition: false
is: HMDB00795
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:51340
name: pristanic acid
type: Species
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial amount: NaN

metaM tyr L e
initial amount: NaN
type: Species
name: L-tyrosine
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00158
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_7ebc3603_d3a4_48ac_bfdc_fe9b6af72d49
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3948
name: LDHC
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
name: retinoic acid transport
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_354dadc1_27f1_4eda_b41c_2c977d2ace96
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: GCAT
initial amount: NaN
is: SBO:0000252
is: E2QC23
is encoded by: hsa:23464
type: Species

metaM cs b deg1 l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16953
is: HMDB00812
initial amount: NaN
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
boundary condition: false
is: SBO:0000247

metaR r0604
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
fast: false
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
kinetic law: MODEL1310110020#

metaM arachd l
is: CHEBI:32395
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01043

metaR r2357
is described by: ECO:0000000
product: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_d52560af_58d0_4983_b7e4_2d67009ba145
boundary condition: true
is encoded by: hsa:441024
initial amount: NaN
is: Q9H903
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: MTHFD2L
constant: false
type: Species

metaR r0464
kinetic law: MODEL1310110020#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_45caf673_eb2e_4fdc_a395_8d3a69bac89d
initial amount: NaN
name: PNPLA3
is: SBO:0000252
boundary condition: true
is: Q9NST1
constant: false
type: Species
is encoded by: hsa:80339
initial concentration: NaN
has only substance units: false

metaR ARACHDt2
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaM gtp m
is: CHEBI:37565
type: Species
is: HMDB01273
initial amount: NaN
is: C00044
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
initial concentration: 1.0
constant: false
name: GTP

metaM hpdca e
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: CHEBI:32366
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: margarate
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaR FAOXC164m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM peamn c
is: CHEBI:225237
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 2-phenylethanaminium
is: HMDB12275
constant: false
boundary condition: false
type: Species

metaM fuc L e
type: Species
has only substance units: false
is: CHEBI:18287
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial amount: NaN
is: SBO:0000247
name: L-fucose
initial concentration: 1.0
boundary condition: false

metaM ksi deg20 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: HMDB00143
name: keratan sulfate I, degradation product 20
has only substance units: false
constant: false
is: CHEBI:12936
type: Species
is: SBO:0000247

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
reversible: true
kinetic law: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9c445e71_07a7_4737_8fd0_982f911d8ef8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1854
is: P33316
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: DUT

http://identifiers.org/biomodels.db/MODEL1310110020#_469d75d3_9d54_4910_86e5_ed9817371b54
is: Q9UMR5
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: PPT2
boundary condition: true
is encoded by: hsa:9374
has only substance units: false

metaM tettet6 e
is: HMDB06246
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
name: tetracosatetraenoic acid n-6
constant: false
type: Species
initial concentration: 1.0

metaR PHCHGSm
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#

metaM 3mlda e
name: 3-Methylimidazoleacetic acid
has only substance units: false
is: http://identifiers.org/pubchem.compound/8122
is: C05828
is: HMDB02820
initial concentration: 1.0
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM xoltetrol c
is: HMDB01231
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
is: CHEBI:17278
boundary condition: false

metaR r0603
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12

metaR r2356
reversible: true
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR r0463
fast: false
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: true

metaM gtp n
type: Species
boundary condition: false
is: HMDB01273
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:37565
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)

metaR DADAe
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
name: Deoxyadenosine deaminase, extracellular
reversible: false
fast: false
product: MODEL1310110020#

metaM adpcoa c
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB04047
type: Species
name: adipoylcoa
initial amount: NaN
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
boundary condition: false
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110020#_f4f35dd5_cfc0_4eb3_aaf2_1fdff4e34693
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC6A6
is encoded by: hsa:6533
constant: false
has only substance units: false
type: Species
is: Q9BRI2
is: SBO:0000252

metaM fpram c
initial amount: NaN
initial concentration: 1.0
constant: false
is: C04640
is: HMDB06211
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58478
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

http://identifiers.org/biomodels.db/MODEL1310110020#_d71e006f_e2de_4ef6_8737_b20f9165fb9b
name: ADCY6
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O43306
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:112

http://identifiers.org/biomodels.db/MODEL1310110020#_46eb659c_919f_43d4_9fe8_630330504930
is: P07205
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: PGK2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5232

http://identifiers.org/biomodels.db/MODEL1310110020#_0d77db09_4008_48d4_896d_75b01716c210
type: Species
is encoded by: hsa:2181
has only substance units: false
initial amount: NaN
name: ACSL3
boundary condition: true
is: O95573
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_e37cf485_0674_442b_8dc5_7c0cf23fb2c1
is: O15121
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8560
name: DEGS1
is: SBO:0000252
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_35b65aef_eef6_4e2c_8207_96775dd00e56
name: SLC26A6
initial concentration: NaN
boundary condition: true
is: Q9NQU1
initial amount: NaN
constant: false
is encoded by: hsa:65010
is: SBO:0000252
type: Species
has only substance units: false

metaM ditp n
name: dITP(4-)
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:61382
initial concentration: 1.0
is: HMDB03537
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false

metaR r2127
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM thbpt4acam n
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02281
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
boundary condition: false
constant: false

metaR PALFATPtc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM fuc L l
name: L-fucose
is: SBO:0000247
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
has only substance units: false
is: HMDB00174
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaM dmnoncoa x
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB11604
has only substance units: false
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false
type: Species

metaM dump c
is: C00365
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
initial amount: NaN
is: SBO:0000247
is: HMDB01409
name: dUMP
has only substance units: false
boundary condition: false
constant: false

metaR r2202
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM 3aib c
is: CHEBI:33094
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB02166
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_107618f6_b9f1_498e_a75c_0b4ba8715349
boundary condition: true
has only substance units: false
initial amount: NaN
name: ST3GAL3
is: SBO:0000252
is encoded by: hsa:6487
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_0e0a0a4f_dc16_43ef_9253_658f1f9c37fe
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR DOPABMO
product: MODEL1310110020#
fast: false
reversible: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110020#
name: dopamine beta-monooxygenase
is version of: http://identifiers.org/ec-code/1.14.17.1

http://identifiers.org/biomodels.db/MODEL1310110020#_926d0b07_4ae9_45e5_909f_8b4d0d360070
constant: false
is encoded by: hsa:286016
type: Species
initial concentration: NaN
boundary condition: true
name: TPI1P2
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r2126
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM tcynt m
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: thiocyanate
constant: false
is: CHEBI:18022
has only substance units: false
boundary condition: false

metaM core6 l
is: SBO:0000247
is: CHEBI:12936
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
name: Core 6

metaR IDOAASE2ly
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
product: MODEL1310110020#
type: Reaction
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false

MODEL1310110020#
species: metaM cytd n
species: metaM CE4790 m
species: metaM tetpent6 e
species: metaM c12dc c
species: metaM hs deg1 l
species: metaM atp c
species: metaM tre e
species: metaM tetdece1coa c
species: metaM hLkynr c
species: metaM ptdcacrn m
species: metaM eicostetcoa c
species: metaM val L m
species: metaM acald e
species: metaM na1 x
species: metaM 5adtststerone c
species: metaM cortsn r
species: metaM c8crn c
species: metaM 3hddcoa m
species: metaM c4dc c
species: metaM 4abutn e
species: metaM glyb e
species: metaM chsterol m
species: metaM ppcoa c
species: metaM adp n
species: metaM btamp m
species: metaM 3ivcrn c
species: metaM cyan c
stoichiometry: 0.020401
species: metaM Rtotal c
species: metaM HC01376 m
species: metaM adpcoa c
species: metaM g2m8masn r
species: metaM 3ohdcoa m
species: metaM l2n2m2mn l
species: metaM C04849 e
species: metaM ksii core4 e
species: metaM CE5101 m
species: metaM pail345p hs c
species: metaM lanost r
species: metaM c8dc c
species: metaM prpp e
species: metaM ivcoa m
species: metaM trdox c
name: ATP1B4:ATP1A1
species: metaM ksi deg13 l
species: metaM gpi sig r
species: metaM CE5119 m
species: metaM 3thexddcoa m
species: metaM glyc R c
species: metaM ocdcea e
species: metaM pre prot r
species: metaM itp e
species: metaM ocdcea r
species: metaM ksi deg1 l
species: metaM dcyt n
species: metaM taur e
species: metaM glygn4 e
species: metaM prgnlones c
species: metaM aicar c
species: metaM hgentis c
species: metaM 3hdeccoa m
species: metaM arab L e
species: metaM ksi pre10 g
species: metaM glyb m
species: metaM ksii core2 pre9 g
species: metaM 3hdcoa m
species: metaM lys L e
species: metaM udp l
species: metaM dutp n
species: metaM amet c
species: metaM tddedi2coa m
stoichiometry: 0.002914
species: metaM ksi pre30 g
species: metaM dhbpt c
species: metaM Lcystin e
species: metaM apoC c
species: metaM 5hoxindoa c
species: metaM dpcoa e
species: metaM dcsptn1crn c
species: metaM o2s c

metaR GLYtm
reversible: true
product: MODEL1310110020#
fast: false
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM glygn5 e
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:33871
notes: FORMULA: C12H21O11X CHARGE: 0
is: HMDB06372
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
constant: false
has only substance units: false
initial amount: NaN

metaR r2201
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR FRUt4
type: Reaction
is described by: ECO:0000269
fast: false
name: D-fructose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_1cd09944_bbab_4603_a9a6_061144d222a7
name: DBH
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P09172
is: SBO:0000252
constant: false
is encoded by: hsa:1621
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_d9a80217_aa74_4b17_85a3_f10513b09cb0
is: SBO:0000252
constant: false
name: ENTPD6
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:955
has only substance units: false
is: O75354
initial amount: NaN

metaR r2200
type: Reaction
modifier: MODEL1310110020#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110020#

metaR EX c8crn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
product: MODEL1310110020#
reactant: MODEL1310110020#
name: pyruvate peroxisomal transport via proton symport
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cd8236b2_d7c9_4db2_8113_1245c3119968
initial concentration: NaN
name: SGPP1
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: Q9BX95
is encoded by: hsa:81537
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_ec0a387b_d898_4820_bd07_65f6db735bea
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4357
is: P25325
type: Species
constant: false
name: MPST

metaR r2129
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_eb76c5ba_a5e3_4344_b9a4_05a1f4bf03b0
constant: false
name: ATP1B1
boundary condition: true
is: A3KLL5
has only substance units: false
initial amount: NaN
is encoded by: hsa:481
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_15f23dd3_1048_46d3_bf6c_21fb94e24245
constant: false
initial amount: NaN
name: ST3GAL4
boundary condition: true
is: Q6IBE6
type: Species
is encoded by: hsa:6484
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d7f968cd_ab3d_4526_8904_fffaf4e9849d
type: Species
is: P49441
name: INPP1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3628
has only substance units: false
initial concentration: NaN
constant: false

metaR r0355
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: false
modifier: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000

metaR r1487
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: EC:6.2.1.3
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM arachd x
is: SBO:0000247
is: HMDB01043
is: CHEBI:32395
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
boundary condition: false
name: arachidonate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_01f53273_b0c7_4080_94e7_7e6c56d9c07a
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6240
is: P23921
is: SBO:0000252
has only substance units: false
name: RRM1

http://identifiers.org/biomodels.db/MODEL1310110020#_597646d9_8089_448b_a90f_c36f4751e326
initial concentration: NaN
is: SBO:0000252
name: FOLR1
type: Species
is encoded by: hsa:2348
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR TDCRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_ad02e9e2_f518_47b3_9c38_7e1802f4ef1f
is: SBO:0000252
initial concentration: NaN
type: Species
name: ATP2B2
constant: false
is encoded by: hsa:491
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q4J699

metaM 3aib e
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02166
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094

http://identifiers.org/biomodels.db/MODEL1310110020#_5761d54a_1187_4cc6_b362_121accf64de4
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
boundary condition: true
is encoded by: hsa:514
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:513
type: Species
initial amount: NaN

metaM dag hs n
is: CHEBI:18035
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
constant: false
name: diglyceride
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR HPETFABP1tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 5-HPETE into the enterocytes
type: Reaction

metaR RTOTALFATPc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR RE2625M
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2625
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR RE3000M
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
name: RE3000
reversible: true
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction

metaM acac m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:13705
boundary condition: false
type: Species
has only substance units: false
name: acetoacetate
is: HMDB00060
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM tyr L c
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17895
name: L-tyrosine
is: HMDB00158
initial amount: NaN

metaR r2128
modifier: MODEL1310110020#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaM malttr e
constant: false
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
is: C01835
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01262
name: maltotriose

metaR r0354
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
is: SBO:0000176

metaR PA HStn
name: phosphatidate transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#

metaM ksi deg12 l
initial amount: NaN
is: HMDB00143
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 12
type: Species
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
constant: false
boundary condition: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110020#_794defff_ba76_49ad_93e7_90791271b801
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AD000092
name: _AD000092_1_c
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_de5a5029_bac4_4eaf_b489_b8405c1407b3
initial amount: NaN
is: O94925
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2744
is: SBO:0000252
constant: false
initial concentration: NaN
name: GLS

http://identifiers.org/biomodels.db/MODEL1310110020#_f392b3d0_f6f4_49e4_9e2f_95aed0e6257e
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:7360
is: Q16851
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: UGP2

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false

metaR S6T7g
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110020#
product: MODEL1310110020#

metaR ADPCOACROT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR TAURtcx
reactant: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
name: taurine transport (sodium symport) (cytosol to peroxisome)
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
product: MODEL1310110020#
is described by: ECO:0000212
is: SBO:0000185
fast: false

metaM 5dhf e
has only substance units: false
type: Species
constant: false
is: HMDB06487
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247

metaM prostge1 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: HMDB01442
has only substance units: false
initial amount: NaN
type: Species
name: prostaglandin E1(1-)
is: CHEBI:57397
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_75aec254_f876_4b00_80fb_962f5bc3ed5f
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:3945
name: LDHB
type: Species
initial concentration: NaN
is: P07195
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_cc46cdfd_b02a_41f3_8caa_0e75eef25d6c
constant: false
boundary condition: true
is encoded by: hsa:2180
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P33121
name: ACSL1

http://identifiers.org/biomodels.db/MODEL1310110020#_bf37ba93_a1d9_4a2f_8a96_5f956aabc267
is encoded by: hsa:6536
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: SLC6A9
is: SBO:0000252
is: B7Z3W8
initial amount: NaN

metaM leuktrF4 e
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: leukotriene F4

http://identifiers.org/biomodels.db/MODEL1310110020#_4ff56140_3922_4bb6_9d99_4f383e8288c6
constant: false
has only substance units: false
is encoded by: hsa:6185
type: Species
boundary condition: true
is: P04844
is: SBO:0000252
initial concentration: NaN
name: RPN2
initial amount: NaN

metaM arachd r
constant: false
type: Species
initial amount: NaN
is: HMDB01043
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_6b529834_e308_42bf_ab34_9cc8ca8f5696
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:51095
is: SBO:0000252
initial amount: NaN
is: Q96Q11
initial concentration: NaN
name: TRNT1
type: Species

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: phosphatidylinositol 4-phosphate phospholipase C
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR GTHRDt
kinetic law: MODEL1310110020#
name: Glutathione transport into mitochondria
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaM nicrnt c
is: HMDB01132
is: C01185
initial concentration: 1.0
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57502
is: SBO:0000247
type: Species

metaR SUBEACTD
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR H2Otp
name: H2O transport, peroxisomal
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false

metaR r1050
reversible: true
name: Vesicular transport
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaR SPODMe
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
name: superoxide dismutase, extracellular
kinetic law: MODEL1310110020#

metaM 3ivcoa c
is: C05998
boundary condition: false
is: HMDB06870
name: 3-hydroxyisovalerylcoa
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
has only substance units: false

metaR RE1845C
is described by: ECO:0000000
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110020#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
modifier: MODEL1310110020#
type: Reaction
name: RE1845

metaR GCNTg
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
is version of: http://identifiers.org/ec-code/2.4.1.150
kinetic law: MODEL1310110020#
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ

metaM ksi deg26 l
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00061
is: CHEBI:58343
is: SBO:0000247
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
constant: false
initial amount: NaN

metaR THBPT4ACAMDASE
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is: SBO:0000176
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110020#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase

metaM htaxol c
initial concentration: 1.0
is: CHEBI:28815
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_b067cd60_54a6_4942_9a15_f09ea799d62e
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q9BV79
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51102
name: MECR
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_26507b8e_01fb_4621_825d_6d3351552dcb
is: Q96FL9
initial concentration: NaN
has only substance units: false
name: GALNT14
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:79623
type: Species

metaR r1610
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000

metaM fuc12gal14acglcgalgluside hs g
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00304
constant: false
name: Type IIH glycolipid
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110020#_ff8a7f0c_64fd_4012_87d4_245434e6745e
is: Q9H0I9
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: TKTL2
is encoded by: hsa:84076
initial amount: NaN
boundary condition: true
type: Species

metaM glyc3p c
name: Glycerol 3-phosphate
is: CHEBI:57597
is: SBO:0000247
is: HMDB00126
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaM Nacasp c
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
is: HMDB00812
initial concentration: 1.0
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_579eca55_0365_41f5_a89a_98e63b27a576
boundary condition: true
name: ACADVL
initial concentration: NaN
is encoded by: hsa:37
has only substance units: false
is: SBO:0000252
is: P49748
initial amount: NaN
constant: false
type: Species

metaR H2Otm
kinetic law: MODEL1310110020#
reversible: true
name: H2O transport, mitochondrial
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269

metaM ksi pre23 g
initial concentration: 1.0
type: Species
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 23
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28067

metaR ASPGLUm
is: SBO:0000185
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR r1051
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000

metaM prostge1 e
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57397
is: HMDB01442

http://identifiers.org/biomodels.db/MODEL1310110020#_ae3122f9_00db_4ac1_8741_3d899caf4f06
type: Species
is encoded by: hsa:9651
has only substance units: false
is: O75038
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PLCH2
initial amount: NaN
constant: false

metaM gtp e
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: GTP(4-)
is: CHEBI:37565
constant: false
is: HMDB01273
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8338efa5_c2a4_40d3_8687_36b9551e130b
is encoded by: hsa:30
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: ACAA1
has only substance units: false
is: Q96CA6

metaR VACCt
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: true

metaR PYRt2m
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110020#
name: pyruvate mitochondrial transport via proton symport

metaM dag hs r
name: diglyceride
initial concentration: 1.0
has only substance units: false
is: CHEBI:18035
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247

metaR RE0583C
product: MODEL1310110020#
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
name: RE0583
reactant: MODEL1310110020#
reversible: true

metaR H2Otn
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#
is: SBO:0000185
name: H2O transport, nuclear
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_aa206652_225c_4239_8df8_cb75d8f4d5f9
constant: false
initial concentration: NaN
is: SBO:0000252
name: PEMT
initial amount: NaN
is encoded by: hsa:10400
has only substance units: false
boundary condition: true
type: Species

metaR DURItn
product: MODEL1310110020#
name: deoxyuridine transport in nucleus
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

metaR FTCD
name: formimidoyltransferase cyclodeaminase
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#

metaR NACHEX8ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110020#
is described by: ECO:0000000
fast: false

metaM htaxol e
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1
initial concentration: 1.0
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:32366
initial amount: NaN
is: HMDB02259

metaR HEXDCRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaM Lfmkynr c
is: HMDB01200
is: CHEBI:30249
constant: false
boundary condition: false
initial concentration: 1.0
name: N-formyl-L-kynurenine
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700

metaM eicostetcoa c
is: SBO:0000247
type: Species
is: C16164
name: eicosatetranoyl coenzyme A
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_2549929a_68f4_4ee8_99cb_802958d017d3
initial concentration: NaN
boundary condition: true
constant: false
name: PTEN
initial amount: NaN
is encoded by: hsa:5728
has only substance units: false
is: SBO:0000252
is: F6KD01
type: Species

metaM hexdicoa c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB02014
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

metaM HC01496 m
type: Species
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28095
has only substance units: false
initial concentration: 1.0
name: 2-Amino-3-oxoadipate
initial amount: NaN

metaM sql r
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
name: squalene
is: CHEBI:15440
boundary condition: false
initial amount: NaN
is: HMDB00256

metaR r1602
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYTDn
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.4.5
type: Reaction
reversible: false
kinetic law: MODEL1310110020#
name: cytidine deaminase, nuclear
fast: false

metaM tcynt e
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
name: thiocyanate
type: Species
boundary condition: false
is: HMDB01453
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_af05490e_e526_451f_93de_4231f67474b7
is: SBO:0000252
is encoded by: hsa:644
has only substance units: false
is: P53004
name: BLVRA
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
type: Reaction
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110020#

metaM pi e
initial amount: NaN
is: C00009
boundary condition: false
constant: false
is: SBO:0000247
name: hydrogenphosphate
type: Species
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110020#_58b00dc8_5808_471f_b808_b67b493540ac
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: PIGA
is: SBO:0000252
is encoded by: hsa:5277
initial amount: NaN

metaM hexdicoa r
is: HMDB00672
is: SBO:0000247
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
name: hexadecanedioylcoa
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR C226CPT2
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
type: Reaction
fast: false
is: SBO:0000176
name: C226 transport into the mitochondria
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_f2bc57f9_4a93_4c8f_ad90_109f5069eb59
has only substance units: false
is encoded by: hsa:23632
is: A8K3J4
is: SBO:0000252
name: CA14
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_94b62de9_611c_48b7_9ac0_2c71aab02633
boundary condition: true
is encoded by: hsa:766
type: Species
initial concentration: NaN
is: P43166
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CA7
constant: false

metaR C14OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR r0236
type: Reaction
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c09f927b_2ac9_4989_a892_55c81bccb7eb
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9Y672
initial amount: NaN
constant: false
is encoded by: hsa:29929
boundary condition: true
name: ALG6

metaM paps g
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01134
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
boundary condition: false

metaR CEPTE
type: Reaction
product: MODEL1310110020#
name: ethanolamine phosphotransferase
is version of: http://identifiers.org/ec-code/2.7.8.2
reactant: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
reversible: false
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM e4hglu m
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
is: HMDB02273
is: CHEBI:6331
constant: false
initial concentration: 1.0
name: erythro-4-hydroxy-L-glutamate(1-)
initial amount: NaN

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR FAOXC123x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM methf m
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (6R)-5,10-methenyltetrahydrofolate
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: HMDB01354

metaM r1p c
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
name: alpha-D-Ribose 1-phosphate
is: HMDB01489
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: C00442
initial concentration: 1.0
is: CHEBI:57720

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110020#

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM m5mpdol L r
initial concentration: 1.0
type: Species
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:37634
is: SBO:0000247
constant: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110020#_0a2439e0_894f_4c62_b4d1_e83ffafb77d3
name: ZADH2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q8N4Q0
is encoded by: hsa:284273
initial amount: NaN

metaR r1600
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110020#

metaR r2120
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#

metaR THYMDtm
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
name: thymd transport
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
reversible: true

metaM docohepcoa m
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
has only substance units: false
type: Species

metaM 3hbcoa m
boundary condition: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01166
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
type: Species
is: CHEBI:57316

metaM adpcoa x
type: Species
name: adipoylcoa
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB04047

metaR CBR2
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Carbonyl reductase [NADPH] 1
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.189
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_b0e35e1c_867a_4be0_9200_61bedb9f4f31
constant: false
is: SBO:0000252
is encoded by: hsa:6817
initial amount: NaN
name: SULT1A1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM pi g
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
name: hydrogenphosphate
is: CHEBI:43474
is: HMDB00973
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM thymd e
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00273
name: Thymidine
is: CHEBI:17748
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaM paps c
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial amount: NaN
initial concentration: 1.0
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
boundary condition: false
is: HMDB01134
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_60e4dffa_3c33_45f9_b954_10c088c0350e
name: NT5C1B
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:93034
type: Species
is: B3KUK6
boundary condition: true
is: SBO:0000252

metaM glyb c
initial concentration: 1.0
type: Species
is: HMDB00043
has only substance units: false
name: glycine betaine
is: CHEBI:17750
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
constant: false
is: SBO:0000247

metaR GALASE15ly
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110020#
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR G14T5g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110020#

metaR GPIMTer L
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
reversible: false
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000000
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
fast: false

metaR r2121
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR FAOXC141C141OHm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaM leuktrF4 c
is: HMDB06465
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27491
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1484d61b_6510_458c_820c_798c375d8ba4
is encoded by: hsa:79369
is: SBO:0000252
is: Q9C0J1
boundary condition: true
initial amount: NaN
constant: false
name: B3GNT4
has only substance units: false
initial concentration: NaN
type: Species

metaR HSD3A2r
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
type: Reaction
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_489358b0_e66d_4c11_ba5c_2087f6101c31
is encoded by: hsa:954
initial concentration: NaN
is: Q5SPY7
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ENTPD2
constant: false
boundary condition: true

metaR O2St
reversible: true
fast: false
reactant: MODEL1310110020#
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaR FADDPle
name: FAD diphosphatase
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110020#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110020#

metaM acetone c
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
name: acetone
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15347
type: Species
is: HMDB01659
constant: false

metaR PEAMNO
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: Phenethylamine oxidase
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
modifier: MODEL1310110020#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110020#
type: Reaction

metaR r1606
reversible: true
fast: false
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185

metaR ORPT
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
name: orotate phosphoribosyltransferase
kinetic law: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110020#
reactant: MODEL1310110020#

metaR FAOXC61C4x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM ksii core2 pre9 g
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
is: CHEBI:28067
has only substance units: false

metaR P4502C9
reversible: false
fast: false
name: cytochrome P450 2C9
product: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.48
notes: GENE_ASSOCIATION: (1559.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES:tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176

metaR r2122
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#

metaR r1735
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
fast: false

metaR r0239
kinetic law: MODEL1310110020#
name: N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 0 AUTHORS: PMID:4140137,PMID:4190298 NOTES:
type: Reaction
product: MODEL1310110020#
reversible: true
is: SBO:0000176

metaM Nacasp m
constant: false
has only substance units: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: HMDB00812
initial concentration: 1.0
type: Species
name: N-acetyl-L-aspartate(2-)
initial amount: NaN
is: CHEBI:16953
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_66f99549_7a91_4a01_91e2_bfe9ec204554
initial amount: NaN
name: PLA2G12A
has only substance units: false
boundary condition: true
is encoded by: hsa:81579
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q542Y6

http://identifiers.org/biomodels.db/MODEL1310110020#_2ac73b0c_a7f0_4d3b_8847_9cddc54d9c6d
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:BG035985
boundary condition: true
name: _BG035985_1_c
initial concentration: NaN
is: SBO:0000252

metaR ADRNCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110020#
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176

metaR ACGAMPM
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.3
is: SBO:0000176
kinetic law: MODEL1310110020#
name: phosphoacetylglucosamine mutase
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000269

metaR C16DCe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR r1605
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR RE0827E
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_326253a6_f3ba_4a49_9bba_2d589e9ae0d2
name: ABAT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:18
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: P80404

metaR r2123
reversible: true
type: Reaction
product: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110020#
is described by: ECO:0000000

metaR GALASE20ly
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110020#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal

metaM thymd m
boundary condition: false
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
is: CHEBI:17748
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00273
initial amount: NaN
name: Thymidine

metaM so4 l
name: sulfate
is: HMDB01448
initial amount: NaN
has only substance units: false
is: CHEBI:16189
initial concentration: 1.0
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
type: Species
boundary condition: false

metaR GULNter
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
name: L-gulonate endoplasmic reticular export
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_abfa20f6_9572_464f_aeef_40521ff1cc41
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: F8WAB8
boundary condition: true
is encoded by: hsa:115286
initial concentration: NaN
name: SLC25A26
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_c4405f16_cab4_4ae5_a4ef_2bd685c1051a
initial concentration: NaN
name: ATP5G3
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:518
is: P48201

metaR ADRNCPT1
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110020#

metaM mescon m
constant: false
is: HMDB00749
name: Mesaconate
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:36986
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial concentration: 1.0
boundary condition: false

metaR NaKt
is described by: ECO:0000269
name: Na+/K+ exchanging ATPase
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000185
reversible: false
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.3.9
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)

metaM s7p c
constant: false
initial amount: NaN
is: CHEBI:57483
is: C05382
type: Species
initial concentration: 1.0
is: HMDB01068
name: Sedoheptulose 7-phosphate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
has only substance units: false

metaR r1604
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR RE3626M
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
name: RE3626
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d3c8aaec_e09b_486d_a317_86c0b26535f8
is: SBO:0000252
initial amount: NaN
name: GBA
boundary condition: true
constant: false
is encoded by: hsa:2629
type: Species
has only substance units: false
initial concentration: NaN

metaM so4 m
is: CHEBI:16189
initial concentration: 1.0
is: HMDB01448
initial amount: NaN
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaM lnlccrn m
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: Linoleyl carnitine

metaM c226coa x
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
is: C16169
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r2124
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110020#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_c5b6cb14_564f_4aa4_9dd2_250cdac214bf
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:314
name: AOC2
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_941ee174_a331_4abb_b014_ce8958070183
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9Y6T7
constant: false
name: DGKB
is encoded by: hsa:1607
is: SBO:0000252
type: Species

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR SUCRe
modifier: MODEL1310110020#
fast: false
type: Reaction
product: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
name: sucrose hydrolyzing enxyme, extracellular
is described by: ECO:0000269
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.20
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.10
is: SBO:0000176

metaR ADPCOAPTE
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaM 3hanthrn c
is: CHEBI:36559
initial amount: NaN
is: HMDB01476
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C7H7NO3 CHARGE: 0 INCHI: InChI=1S/C7H7NO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,8H2,(H,10,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00464 EHMN_ABBREVIATION: C00632
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3-hydroxyanthranilate

http://identifiers.org/biomodels.db/MODEL1310110020#_35f1581e_9102_4017_b1df_cc6d4c87b16b
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8813
is: O60762
name: DPM1
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR S4TASE3ly
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.12
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false

metaM hexdectecoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial amount: NaN
name: 2,4,7,10-hexadecatetraenoylcoa
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_b8873a9b_04b6_4bb3_9a92_f502b8b8166b
boundary condition: true
is: Q8N0W3
is encoded by: hsa:197258
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: FUK

metaR ASNTHRNaEx
modifier: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
reversible: false
product: MODEL1310110020#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_53a8574b_1b73_4acd_b7f9_e280a07e0c19
is: SBO:0000252
is encoded by: hsa:1593
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q02318
constant: false
initial amount: NaN
name: CYP27A1

metaR C16DCc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_b4d449f4_6030_4a23_a52b_f7888d89a1c0
name: PIGF:PIGO
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:84720
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:5281
has only substance units: false
constant: false
has part: Q6IB04

metaR 4NPHte
fast: false
type: Reaction
reversible: true
name: xenobiotic transport
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
is described by: ECO:0000000

metaR r1603
fast: false
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SERLYSNaex
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: Serine/Lysine Na-dependent exchange (Ser in)
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
product: MODEL1310110020#
type: Reaction
fast: false
is described by: ECO:0000212

metaR ECOAH1m
kinetic law: MODEL1310110020#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reversible: true
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DGAT
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.20
fast: false
name: diacylglycerol acyltransferase
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176

metaR r2125
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM arachdcrn x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
is: HMDB01064
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
name: C20:4 carnitine

metaM pi l
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00973
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
name: hydrogenphosphate
constant: false

metaR PROSTGI2t
reactant: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reversible: true
name: Prostaglandin I2 transport
fast: false
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185

metaR ORNt3m
reactant: MODEL1310110020#
name: ornithine mitochondrial transport via proton antiport
reversible: true
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_fc91420e_718a_445c_95f1_55560ad5be5e
is: SBO:0000252
has only substance units: false
name: BCAT1
type: Species
constant: false
is encoded by: hsa:586
is: P54687
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR TYRt4
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000304
product: MODEL1310110020#
is: SBO:0000185
type: Reaction
name: L-tyrosine transport in via sodium symport
reversible: false

metaR HPYRR2x
fast: false
is described by: ECO:0000304
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
name: hydroxypyruvate reductase (NADH)
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110020#

metaM gbside hs l
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:18259
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: globoside

metaR r2354
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction

metaR CHOLPtg
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
name: choline phosphate intracellular transport
fast: false
is: SBO:0000185
reversible: true

metaR BDHm
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
modifier: MODEL1310110020#
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
fast: false
is: SBO:0000176

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
fast: false
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000176
product: MODEL1310110020#
name: ribulose 5-phosphate 3-epimerase

metaM galthcrm hs g
initial concentration: 1.0
initial amount: NaN
name: Gal-Gal-Gal-Glc-Cer
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:26174
constant: false
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_d548b674_3787_4e96_8ef4_e38fc76ffc2b
is encoded by: hsa:29968
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: PSAT1
constant: false
initial concentration: NaN

metaM pi m
is: HMDB00973
type: Species
constant: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00009

metaR ENGASEly
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: false
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_cc8e7691_bc80_41c3_b0ae_55fd3406887d
type: Species
has only substance units: false
is encoded by: hsa:AV717590
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: _AV717590_1_c

http://identifiers.org/biomodels.db/MODEL1310110020#_d71c7486_8350_4ac8_9a8f_31746e5fd204
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q86VV3
name: ENTPD1
is encoded by: hsa:953
boundary condition: true
type: Species
initial concentration: NaN

metaR It
product: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110020#
fast: false
name: Iodide uniport

metaM gcald c
is: CHEBI:17071
initial amount: NaN
has only substance units: false
name: glycolaldehyde
is: HMDB03344
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM methf c
is: SBO:0000247
initial amount: NaN
is: CHEBI:57455
name: 5,10-Methenyltetrahydrofolate
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
is: C00445
constant: false
is: HMDB01354
initial concentration: 1.0
type: Species

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR RE1845X
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
name: RE1845
type: Reaction
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1d755902_1560_47dc_85d1_65b69dcb6772
initial amount: NaN
is encoded by: hsa:AI373818
name: _AI373818_1_m
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM sph1p e
boundary condition: false
type: Species
is: CHEBI:57939
is: SBO:0000247
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
is: HMDB01383
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
constant: false

metaM arachd e
initial amount: NaN
is: HMDB01043
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR RTOTAL3FATPc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM pi n
name: hydrogenphosphate
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00973
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110020#_167d946a_161f_421c_8f39_6010328ec5d0
is encoded by: hsa:7372
initial concentration: NaN
type: Species
boundary condition: true
name: UMPS
is: A8K5J1
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR Asn X Ser Thrtr
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
is: SBO:0000185
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_54b45487_0b8e_4152_9c83_79257772e862
is encoded by: hsa:U37519
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: _U37519_1_e
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_6dd53247_44f0_4683_9c0d_01b9ad6a5129
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5313
has only substance units: false
name: PKLR
constant: false
initial amount: NaN
boundary condition: true

metaR FAOXC164x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM urea m
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: SBO:0000247
initial concentration: 1.0
is: HMDB00294
boundary condition: false
has only substance units: false
is: CHEBI:16199
type: Species
initial amount: NaN
constant: false
name: Urea
is: C00086

metaR FAOXC241C221x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM c3dc c
boundary condition: false
name: malonyl carnitine
notes: FORMULA: C10H16NO6 CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02095
is: SBO:0000247

metaR r1609
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r2355
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR SBTR
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
type: Reaction
name: D-sorbitol reductase
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110020#

metaR r2352
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110020#

metaR CLPNDCOAtx
product: MODEL1310110020#
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000

metaR HISTAtu
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110020#
reversible: true
is: SBO:0000185
name: Histamine uniport
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_7e2c471e_afb3_4b1b_a216_62f23f9a1af4
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3033
is: Q16836
boundary condition: true
name: HADH
type: Species
is: SBO:0000252
initial amount: NaN

metaR ACHtn
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
name: Acetylcholin transport, nuclear trhough pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110020#
type: Reaction

metaM glyb m
is: CHEBI:17750
type: Species
initial amount: NaN
is: HMDB00043
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR NAIt
name: Na+ / iodide cotransport
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reactant: MODEL1310110020#
reversible: true
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_3a4b35c1_e221_47e2_9f49_c7902b42ccb5
initial amount: NaN
is: E9PB82
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: HSD17B4
type: Species
constant: false
is encoded by: hsa:3295

metaR DGCHOLtx
product: MODEL1310110020#
reactant: MODEL1310110020#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM hexdectecoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: HMDB02288
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_af138e74_1a3b_4b7c_b00d_864908df5862
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: ABP1
is: P19801
initial concentration: NaN
has only substance units: false
is encoded by: hsa:26

metaR r1608
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#

metaR CYTDt
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: cytidine facilated transport in cytosol
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269

metaR r2353
reactant: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d1a8a72f_7b86_4557_96f3_6d199d3a7a57
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AA576959
constant: false
name: _AA576959_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1f4bd3db_3516_428c_a036_2da7f181d71f
initial amount: NaN
initial concentration: NaN
is: P04179
name: SOD2
is encoded by: hsa:6648
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM CE1935 e
initial concentration: 1.0
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
name: spermine monoaldehyde
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:30623
is: HMDB02329
constant: false
is: SBO:0000247
initial amount: NaN

metaM sph1p c
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
boundary condition: false
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
type: Species
is: CHEBI:57939

metaR G14T10g
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM c226coa m
has only substance units: false
is: SBO:0000247
is: C16169
type: Species
name: cervonyl coenzyme A
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479

metaR OAADC
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaR FAOXC123m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9962fe37_96a3_4e2b_a6a3_0942e2f8c551
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: CHDH
is encoded by: hsa:55349
is: Q8NE62

metaM c3dc e
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H16NO6 CHARGE: -1
initial amount: NaN
name: malonyl carnitine
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02095

metaR r1607
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110020#
reversible: true

metaR GLYCt
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
fast: false
name: glycerol transport via channel
product: MODEL1310110020#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM 5adtststerones c
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB06278
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_0716e8ad_d67b_47c9_b526_00666d139170
is: SBO:0000252
initial concentration: NaN
name: GMPPA
is: Q96IJ6
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:29926
has only substance units: false

metaM tststerone e
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
is: HMDB00234
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17347
has only substance units: false
initial amount: NaN

metaM doco13ecoa x
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
name: 13-docosenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110020#_b2e3bae4_763b_4c40_b38b_1411867f7a96
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54872
is: Q8NCI4
boundary condition: true
constant: false
type: Species
name: PIGG
is: SBO:0000252

metaM gbside hs g
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: globoside
is: SBO:0000247
initial amount: NaN
is: CHEBI:18259

http://identifiers.org/biomodels.db/MODEL1310110020#_b7339122_f529_430b_b5cc_6836f64aa8dd
boundary condition: true
constant: false
name: SLC8A3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6547

metaR DAGt
fast: false
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
name: diacylglycerol transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaR HMGCOAtx
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
is described by: ECO:0000000
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

metaR CITRtm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
modifier: MODEL1310110020#
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
reversible: true
type: Reaction
reactant: MODEL1310110020#

metaR RE2625C
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000000
name: RE2625
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#

metaM mi1345p c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57895
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: HMDB01059
constant: false

metaM duri n
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
is: HMDB00012
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16450
constant: false
name: 2'-deoxyuridine

metaR XOL7AONEtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
type: Reaction

metaM HC01415 m
initial concentration: 1.0
is: SBO:0000247
name: (2E)-Octenoyl-CoA
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:27537
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaM retn e
name: all-trans-retinoate
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: HMDB01852
is: CHEBI:35291
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR NADPtxu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
name: NADP transporter, peroxisome
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000185

metaM CE1939 e
type: Species
has only substance units: false
name: spermidine monoaldehyde 1
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:36781
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_fa3956f5_00ff_4382_bea6_0e171dd225f2
is: O43678
name: NDUFA2
is encoded by: hsa:4695
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_441e59ee_b90f_48aa_8d3d_2b243600dc91
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:8622
is: O95263
name: PDE8B
is: SBO:0000252
constant: false

metaR PCHOLP hs
type: Reaction
product: MODEL1310110020#
name: choline phosphatase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269
modifier: MODEL1310110020#

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_c298d379_8dc5_47d9_b5e0_af4d74945777
is encoded by: hsa:5151
constant: false
initial amount: NaN
name: PDE8A
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM arachdcrn m
is: CHEBI:57387
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
constant: false
name: C20:4 carnitine
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7aba6ff8_62c8_4b52_8273_f66a07cd48a4
has only substance units: false
boundary condition: true
name: SLC6A4
constant: false
type: Species
initial amount: NaN
is: P31645
is encoded by: hsa:6532
initial concentration: NaN
is: SBO:0000252

metaR RE0936E
is described by: ECO:0000000
modifier: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: RE0936
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
fast: false
reversible: true
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.17.23

http://identifiers.org/biomodels.db/MODEL1310110020#_5c62397c_c465_4816_a65a_9b7c9514eb23
constant: false
is: Q9BXI2
name: SLC25A2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:83884

metaR ACOAO7p
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reversible: false
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM glyb e
constant: false
boundary condition: false
is: CHEBI:17750
initial concentration: 1.0
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
has only substance units: false
is: HMDB00043
name: glycine betaine
initial amount: NaN

metaR ABO6g
reversible: false
fast: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
boundary condition: false
constant: false
type: Species
is: CHEBI:43474
has only substance units: false
is: C00009
initial amount: NaN
initial concentration: 1.0
name: hydrogenphosphate
is: SBO:0000247

metaR B3GNT34g
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000176

metaM 5adtststerones e
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
type: Species
has only substance units: false
constant: false
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM tststerone c
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
initial concentration: 1.0
is: HMDB00234
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:17347
is: SBO:0000247
initial amount: NaN

metaR AG13T8g
reactant: MODEL1310110020#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaR DCTPtn
product: MODEL1310110020#
name: dCTP diffusion in nucleus
fast: false
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_330b6b55_457d_41fd_9fd4_53d0f6d323cb
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000297
type: Species
initial amount: NaN
is encoded by: hsa:54344
initial concentration: NaN
is encoded by: hsa:8818
has part: Q9P2X0
name: DPM3:DPM1:DPM2

http://identifiers.org/biomodels.db/MODEL1310110020#_74a1e6e6_42bf_4fa8_abf1_43f070b3a8d1
is: G0W2N5
type: Species
is encoded by: hsa:6563
initial amount: NaN
constant: false
has only substance units: false
name: SLC14A1
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM subeac x
name: suberic acid
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00893
constant: false
is: SBO:0000247
notes: FORMULA: C8H12O4 CHARGE: -2

metaM gbside hs e
name: globoside
initial amount: NaN
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:18259
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaM hs deg21 l
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00127
is: CHEBI:15748
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaM phaccoa c
is: SBO:0000247
constant: false
is: CHEBI:57390
initial amount: NaN
name: phenylacetyl-CoA(4-)
is: HMDB06503
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM Sfglutth c
is: SBO:0000247
constant: false
type: Species
is: HMDB01550
initial concentration: 1.0
boundary condition: false
is: CHEBI:57688
name: S-formylglutathionate(1-)
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN

metaM mlthf m
type: Species
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:15636
boundary condition: false
initial concentration: 1.0
is: C00143
is: HMDB01533

http://identifiers.org/biomodels.db/MODEL1310110020#_6da3b152_1ab9_4956_bd8b_ad9d8afab7c5
boundary condition: true
constant: false
is encoded by: hsa:8833
initial concentration: NaN
initial amount: NaN
name: GMPS
type: Species
is: SBO:0000252
is: P49915
has only substance units: false

metaM tcynt c
boundary condition: false
is: HMDB01453
is: CHEBI:18022
initial amount: NaN
initial concentration: 1.0
name: thiocyanate
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR r2011
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM ditp c
is: SBO:0000247
is: HMDB03537
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:61382
initial concentration: 1.0
name: dITP(4-)
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM retn c
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
has only substance units: false
is: SBO:0000247
name: all-trans-retinoate
initial amount: NaN
is: HMDB01852
is: CHEBI:35291
type: Species
constant: false

metaM arachd c
type: Species
is: HMDB01043
name: arachidonate
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_6228511a_0729_41ef_a03a_d23ff3474de3
is: P48735
name: IDH2
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3418

metaM odecrn m
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
has only substance units: false
is: C00412
is: HMDB01114
is: CHEBI:57394
boundary condition: false
type: Species
name: octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110020#_5c28d9d2_5096_4e7d_8d0a_22b96779d977
has only substance units: false
name: _AI091231_1_c
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI091231
constant: false

metaR S6TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_af4a4897_ee56_4ad2_a723_dd658e7ec916
is: SBO:0000252
constant: false
is encoded by: hsa:10327
initial concentration: NaN
name: AKR1A1
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR SBTD D2
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.14
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: D-sorbitol dehydrogenase (D-fructose producing)

metaR CYTK4n
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: cytidylate kinase (dCMP,GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110020#

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM glyclt x
has only substance units: false
is: CHEBI:29805
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: glycolate
is: HMDB00115
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaR GLXtm
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
name: glyoxylate transport, mitochondrial
kinetic law: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_54d09af8_ea19_4e21_b551_69ded83a9480
has only substance units: false
name: PECR
initial concentration: NaN
constant: false
is encoded by: hsa:55825
is: SBO:0000252
is: Q9BY49
type: Species
initial amount: NaN
boundary condition: true

metaM urea c
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
boundary condition: false
name: Urea
initial concentration: 1.0
is: CHEBI:16199
constant: false
type: Species
is: HMDB00294
is: SBO:0000247
has only substance units: false
is: C00086

http://identifiers.org/biomodels.db/MODEL1310110020#_26f97d5e_a4d1_43d3_9182_7f09eebfcf5c
is: Q8N9L9
initial concentration: NaN
is encoded by: hsa:122970
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: ACOT4

metaR S6TASE8ly
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#

metaR r0472
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_f92426ff_27f8_4a39_8a79_41ce601d64dc
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:22978
type: Species
is: P49902
initial concentration: NaN
has only substance units: false
name: NT5C2

http://identifiers.org/biomodels.db/MODEL1310110020#_d276738f_8338_4d1c_a1e6_b0b8f9601202
is: SBO:0000252
is: O43252
initial amount: NaN
name: PAPSS1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:9061
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_40b31ecf_9d39_4f12_abe9_08d8390583d7
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: SLC4A5
is encoded by: hsa:57835
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_53560a19_3d75_4846_838b_1d0941fd1dc2
type: Species
name: PRDX2
has only substance units: false
constant: false
is encoded by: hsa:7001
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR FADH2tru
is described by: ECO:0000000
is: SBO:0000185
name: FADH2 transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR ACACt2m
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
type: Reaction
name: Acetoacetate mitochondrial transport via H+ symport
reversible: true
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a360327b_a878_4e04_a8f4_fb033b1a246e
boundary condition: true
is: O75414
initial concentration: NaN
name: NME6
initial amount: NaN
constant: false
is encoded by: hsa:10201
has only substance units: false
is: SBO:0000252
type: Species

metaR r0899
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
product: MODEL1310110020#

metaM 42A3HP24DB c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB04083
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
is: C05645
boundary condition: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/7956

metaR PCm
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
fast: false
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1
is described by: ECO:0000269
modifier: MODEL1310110020#
reversible: false
type: Reaction

metaM sucsal m
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57706
boundary condition: false
has only substance units: false
is: HMDB01259
constant: false
name: Succinic semialdehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_f9f37435_1af6_4598_9a6a_10923e2effee
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:130367
name: SGPP2
initial concentration: NaN
is: Q8IWX5
type: Species
initial amount: NaN
is: SBO:0000252

metaM f1a g
is: SBO:0000247
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02917

metaM c226coa c
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: cervonyl coenzyme A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_f216a754_1f19_470f_8398_d3dcdaeb38de
has only substance units: false
is: SBO:0000252
is: Q5JAM2
initial concentration: NaN
type: Species
name: ALAS1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:211

metaM octdececoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
name: octadecenoylcoa

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR B3GNT36g
modifier: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#

metaM 2dodtricoa m
is: C05279
constant: false
boundary condition: false
has only substance units: false
is: HMDB11123
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial amount: NaN

metaM retn r
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:35291
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852

metaR ABO4g
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.37

metaM urea e
is: CHEBI:16199
name: Urea
initial concentration: 1.0
has only substance units: false
constant: false
is: C00086
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00294

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623
initial amount: NaN
name: (3S)-3-hydroxylinoleoyl-CoA
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB02329
constant: false
type: Species

metaR HS3ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110020#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000

metaM pap c
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: CHEBI:58343
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR SO4t4 2
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000185
fast: false
product: MODEL1310110020#
reversible: true

metaM ksii core4 g
is: HMDB03418
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
has only substance units: false
is: CHEBI:16443
is: SBO:0000247

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR H2Oter
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110020#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaR FAOXC201C181x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_91af4a26_96f9_4874_b18c_f2eb58f0002d
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: P11908
name: PRPS2
is encoded by: hsa:5634

metaM 4ppcys m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: HMDB01117
initial concentration: 1.0
boundary condition: false
is: CHEBI:59458
type: Species

metaR DOPASFt
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
type: Reaction
fast: false
product: MODEL1310110020#
name: Dopamine 3-0-sulfate transport (diffusion)

metaR ALCD21 D
name: alcohol dehydrogenase (D-1,2-propanediol)
product: MODEL1310110020#
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1e468740_7563_49b1_ae94_8c7e2a2591ab
boundary condition: true
is: Q11201
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6482
initial amount: NaN
name: ST3GAL1

metaR AG13T7g
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_e4aa63d6_e37d_411f_9f09_70125b6af776
name: ZADH2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:284273
initial amount: NaN
initial concentration: NaN
is: Q4G1C4
type: Species

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58335
is: SBO:0000247
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0

metaM gbside hs c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: globoside

metaM hyptaur c
initial amount: NaN
is: HMDB00965
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247
is: CHEBI:16668
initial concentration: 1.0
name: Hypotaurine

metaR GALASE1ly
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110020#

metaM ksi pre22 g
constant: false
is: SBO:0000247
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: CHEBI:58053
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN
initial concentration: 1.0
is: HMDB00175
has only substance units: false
is: C00130

metaM dgsn m
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00085
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: CHEBI:17172
name: Deoxyguanosine
has only substance units: false

metaM ksi deg8 l
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_88537cbd_f852_4d36_b651_a352edbff294
is: O14975
type: Species
name: SLC27A2
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11001
boundary condition: true

metaM asn L c
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
name: L-asparagine
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00168
boundary condition: false
type: Species
constant: false

metaR CERT1rt
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
reversible: true
modifier: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_e02bef4f_ec89_4905_b6f7_73ec62f408f3
is: SBO:0000252
name: SC5DL
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: Q6GTM5
has only substance units: false
is encoded by: hsa:6309

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_8d84c830_3fd2_456d_b069_147129f87211
initial amount: NaN
constant: false
name: CHKA
type: Species
boundary condition: true
is encoded by: hsa:1119
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r2369
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110020#
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a890e118_0094_4f88_80d6_67e84787b597
is: Q9Y6K8
name: AK5
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:26289
initial amount: NaN
boundary condition: true
has only substance units: false

metaM ksii core4 l
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: HMDB03418
initial amount: NaN
is: CHEBI:16443
constant: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked)

metaR FAS180COA
reactant: MODEL1310110020#
is described by: ECO:0000269
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110020#
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C18:0CoA)
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR r0475
is: SBO:0000176
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2816739a_dec6_4bf3_ba29_0e8268c66fed
type: Species
name: _AA021081_1_r
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AA021081
initial concentration: NaN

metaR PSYGCHe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR C161CPT22
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
name: C161 transport into the mitochondria
kinetic law: MODEL1310110020#

metaR r2368
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110020#
fast: false
reversible: true
reactant: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport

metaR H2CO3D
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
is: SBO:0000176
fast: false
name: carboxylic acid dissociation
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1

metaM pydx e
is: CHEBI:17310
type: Species
name: Pyridoxal
has only substance units: false
is: SBO:0000247
constant: false
is: C00250
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: HMDB01545

http://identifiers.org/biomodels.db/MODEL1310110020#_1cd0b1a0_642f_4996_aeff_34243b5e6182
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:8560
name: DEGS1
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_1d2c1c42_7539_4c19_81c5_0539aacf075a
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDH4A1
is: P30038
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8659

metaM asn L e
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
is: SBO:0000247
name: L-asparagine
is: HMDB00168
has only substance units: false
constant: false
type: Species
is: CHEBI:17196
boundary condition: false

metaR r0002
name: Active transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#
fast: false
is: SBO:0000185
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a32a0f2d_6fdf_478c_b307_86ca6c87fcd5
initial concentration: NaN
constant: false
is: O14732
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3613
name: IMPA2
has only substance units: false

metaR r0474
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110020#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110020#
fast: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM 3hexdcoa m
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
type: Species
initial amount: NaN
is: HMDB03932
name: 3-hydroxyhexadecanoylcoa
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C05258

metaM focytC m
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16928
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
name: Ferrocytochrome C

metaR GUMTCHOLe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM acetone m
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
type: Species
is: CHEBI:15347
has only substance units: false
name: acetone
initial concentration: 1.0
is: HMDB01659
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_712ae702_c3c9_4d25_829f_d549dd1c329d
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:471
is: P31939
name: ATIC
has only substance units: false
is: SBO:0000252

metaM chsterol c
is: HMDB00067
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
name: cholesterol
constant: false
initial amount: NaN
is: CHEBI:16113
has only substance units: false

metaR GLXtp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
product: MODEL1310110020#
fast: false
name: glyoxylate transport, peroxisomal
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaR GLYSNAT5tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR AG13T10g
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM pydx c
initial amount: NaN
is: C00250
is: SBO:0000247
boundary condition: false
is: CHEBI:17310
initial concentration: 1.0
name: Pyridoxal
has only substance units: false
type: Species
is: HMDB01545
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_74468175_60b3_49fd_b56f_a6328d1f314e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: CRAT
type: Species
is encoded by: hsa:1384
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_ab152750_aee4_4cf3_be85_1a0a229612b9
is: P27707
has only substance units: false
name: DCK
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1633
type: Species

metaR P5CR
type: Reaction
name: pyrroline-5-carboxylate reductase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110020#

metaM CE4872 c
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
is: HMDB00127
has only substance units: false
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
initial amount: NaN
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110020#_ffa5fd63_a939_4f17_a333_ce2514f8a540
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:6582
is: SBO:0000252
name: SLC22A2
constant: false
initial concentration: NaN
type: Species

metaR r2117
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR DM anth
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
name: 3HCO3_NAt
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000134
reversible: true
product: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction

metaR ADAe
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110020#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
name: Adenosine deaminase, extracellular
is: SBO:0000176
product: MODEL1310110020#

metaR S6T8g
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
product: MODEL1310110020#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM fru c
is: SBO:0000247
is: HMDB00660
initial concentration: 1.0
is: C00095
type: Species
constant: false
is: CHEBI:15824
name: D-Fructose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false
has only substance units: false

metaR MAL Lte
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of L-malate
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_491b56e0_e3b3_449a_bd0a_bfe171a950f4
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ATP5G2
is encoded by: hsa:517
is: Q06055
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR LCADi D
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000304
name: lactaldehyde dehydrogenase
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction

metaM duri e
is: C00526
boundary condition: false
is: CHEBI:16450
type: Species
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: HMDB00012
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: Deoxyuridine

metaR DALAt2r
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
name: D-alanine transport via proton symport
product: MODEL1310110020#
reversible: true
is described by: ECO:0000304
fast: false
is: SBO:0000185

metaR P4502C8
modifier: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.14.14.1
name: cytochrome P450 2C8
is described by: ECO:0000304

metaM 3hexdcoa c
boundary condition: false
constant: false
has only substance units: false
is: C05258
is: HMDB03932
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
name: 3-hydroxyhexadecanoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM c16dc c
has only substance units: false
type: Species
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00712
boundary condition: false

metaR r2116
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110020#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185

metaR NDP7g
product: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110020#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1fb6b4c2_bcac_4030_aa16_9c2daeaedb0b
is: Q16678
is encoded by: hsa:1545
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: CYP1B1
is: SBO:0000252
initial amount: NaN

metaR DHEAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
kinetic law: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110020#
name: Dehydroepiandrosterone transport

metaM 2dodtricoa x
has only substance units: false
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C05279
type: Species
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110020#_acf2fc78_e8c2_447d_8d12_6efdb477cc16
is: Q5JWV8
is encoded by: hsa:2182
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACSL4
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR MAN1PT2
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
product: MODEL1310110020#
name: mannose-1-phosphate guanylyltransferase (GDP)
is version of: http://identifiers.org/ec-code/2.7.7.13
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110020#
fast: false

metaM h x
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:24636
name: proton
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3380

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_91a70121_6801_4292_bd6e_723f10d1c947
has only substance units: false
is encoded by: hsa:51733
initial amount: NaN
name: UPB1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: B3KNC1

http://identifiers.org/biomodels.db/MODEL1310110020#_32ff6661_c3c1_4707_9af2_b06f696e8353
initial amount: NaN
is encoded by: hsa:23305
boundary condition: true
has only substance units: false
type: Species
is: B2RB13
constant: false
name: ACSL6
is: SBO:0000252
initial concentration: NaN

metaR HMGCOAtm
is described by: ECO:0000000
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

metaR GHMT2r
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
name: glycine hydroxymethyltransferase, reversible
is described by: ECO:0000269

metaM fru e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
initial concentration: 1.0
is: C00095
constant: false
type: Species
is: CHEBI:15824
initial amount: NaN
is: SBO:0000247
name: D-Fructose
is: HMDB00660
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5af959a3_19ba_423f_8ae7_ff9f4ad90cd3
type: Species
initial concentration: NaN
is encoded by: hsa:28232
name: SLCO3A1
constant: false
is: Q9UIG8
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR RE3301C
fast: false
modifier: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: RE3301
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_483ec480_c3c6_4501_8a09_e76c49f1e5e1
is: SBO:0000252
name: PYCR2
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q96C36
is encoded by: hsa:29920

http://identifiers.org/biomodels.db/MODEL1310110020#_d91e349f_2e2a_499f_aaec_85bdc842558b
is: P07101
constant: false
is encoded by: hsa:7054
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: TH

metaM duri c
is: HMDB00012
is: CHEBI:16450
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
type: Species
is: C00526
initial amount: NaN
name: Deoxyuridine

metaM prist c
has only substance units: false
is: CHEBI:51340
name: pristanic acid
initial amount: NaN
is: HMDB00795
is: SBO:0000247
constant: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
boundary condition: false
type: Species
initial concentration: 1.0

metaR r1730
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaM agm m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H16N4 CHARGE: 2 INCHI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)/p+2 HEPATONET_1.0_ABBREVIATION: HC00171 EHMN_ABBREVIATION: C00179
is: HMDB01432
type: Species
name: agmatinium(2+)
constant: false
is: CHEBI:58145
boundary condition: false

metaR r1497
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110020#
reversible: false
type: Reaction

metaR r0365
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_c72f5db5_2e33_4f89_87f9_5266fdde04a5
boundary condition: true
is encoded by: hsa:482
initial amount: NaN
type: Species
has only substance units: false
has part: P14415
initial concentration: NaN
constant: false
name: ATP1A3:ATP1B2
is: SBO:0000297

metaR r2114
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110020#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR DESAT22 2p
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
fast: false
reversible: false
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

metaR MALTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
name: Malate:thiosulfate antiport, mitochondrial

metaM omhpal c
boundary condition: false
constant: false
initial concentration: 1.0
name: w-hydroxypalmiticacid
is: HMDB06294
notes: FORMULA: C16H30O3 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaM dgcholcoa x
boundary condition: false
is: HMDB06897
is: C05461
has only substance units: false
initial concentration: 1.0
name: Chenodeoxyglycocholoyl-CoA
type: Species
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
is: SBO:0000247
initial amount: NaN

metaM C04849 e
boundary condition: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial amount: NaN
constant: false
is: CHEBI:57449
initial concentration: 1.0
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
has only substance units: false

metaM 11 cis retfa e
is: HMDB00972
is: CHEBI:57454
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: fatty acid 11-cis-retinol

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR r1731
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110020#
reversible: false

metaM HC01459 x
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:27458
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_5ce2bf7f_57e3_46ab_b52c_91701c8552c9
has part: O94777
initial amount: NaN
is: SBO:0000297
name: DPM3:DPM1:DPM2
is encoded by: hsa:54344
boundary condition: true
is encoded by: hsa:8818
initial concentration: NaN
has only substance units: false
has part: Q86TM7
has part: O60762
is encoded by: hsa:8813
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_874e749c_8aa2_4278_a1fe_b78339214bce
boundary condition: true
is encoded by: hsa:121278
name: TPH2
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: Q8IWU9
has only substance units: false
constant: false

metaR CBPSam
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (1373.1) or (1373.2) SUBSYSTEM: Glutamate metabolism EC Number: 6.3.4.16 Confidence Level: 4 AUTHORS: PMID:10347186,PMID:12853138 NOTES:MM
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000269
type: Reaction
name: carbamoyl-phosphate synthase (ammonia) (mitochondria
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.3.4.16
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1d4a3ad0_2080_4308_8a62_c5bf4f3f3210
initial amount: NaN
type: Species
name: GGT2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:728441
has only substance units: false
boundary condition: true

metaR PETOHMm hs
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.1.1.17
product: MODEL1310110020#
reversible: false
fast: false
name: phosphatidylethanolamine N-methyltransferase
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#

metaR B3GALT3g
type: Reaction
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM tststerone r
type: Species
is: CHEBI:17347
constant: false
name: testosterone
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: HMDB00234
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM 2dr1p c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58576
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
boundary condition: false
is: C00672
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01351
name: 2-Deoxy-D-ribose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110020#_a95a3f49_ffba_47f0_9b7a_5d2a5caf994d
constant: false
name: ABP1
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:26
is: P19801
initial concentration: NaN
boundary condition: true

metaR 5ADTSTSTERONESte
product: MODEL1310110020#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110020#
name: sulfonated testosterone transport
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ

http://identifiers.org/biomodels.db/MODEL1310110020#_a506c518_7ca1_47a5_91f1_dbbee2836ffc
type: Species
name: EHHADH
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1962
initial concentration: NaN
is: Q9NY65

metaM xtsn c
initial concentration: 1.0
boundary condition: false
is: HMDB00299
type: Species
is: CHEBI:18107
initial amount: NaN
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
has only substance units: false
is: SBO:0000247

metaM so4 e
has only substance units: false
name: sulfate
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01448

metaM ksii core4 e
is: HMDB00211
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17268
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
type: Species
is: HMDB01117
is: CHEBI:59458
is: SBO:0000247
boundary condition: false
is: C04352
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

metaM CE4872 m
has only substance units: false
is: HMDB00127
type: Species
is: CHEBI:15748
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247

metaM pap g
constant: false
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58343
is: HMDB00061
initial amount: NaN
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)

metaM acetone e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: acetone
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
is: SBO:0000247
is: CHEBI:15347
type: Species

metaR GLCter
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
is described by: ECO:0000000
name: glucose transport, endoplasmic reticulum
fast: false
type: Reaction
reversible: true

metaR SEBCOAPET
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR C30CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaR r0361
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.1.3.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_c7eaee12_ecf0_4039_a258_e93398dda65d
is encoded by: hsa:1716
type: Species
is: Q16854
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: DGUOK

metaR r2119
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185
modifier: MODEL1310110020#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaM asn L m
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00168
type: Species
constant: false
is: SBO:0000247
name: L-asparagine

metaR O2t
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: o2 transport (diffusion)
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaR r0789
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR PCt
name: phosphatidylcholine transporter
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.3.44
is described by: ECO:0000269
product: MODEL1310110020#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110020#

metaM dolglcp L c
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
initial amount: NaN
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_709f5469_e7bb_4035_ad6c_b068044db944
is: Q9P109
constant: false
is: SBO:0000252
has only substance units: false
name: GCNT4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:51301

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR HCO3 CLt
name: bicarbonate transport (Cl-/HCO3- exchange)
is: SBO:0000185
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269

metaM mmcoa R m
boundary condition: false
is: CHEBI:57326
has only substance units: false
name: (R)-methylmalonyl-CoA(5-)
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01269
type: Species

metaR r0360
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.16

metaM ivcoa m
is: SBO:0000247
name: Isovaleryl-CoA
is: CHEBI:57345
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial concentration: 1.0
is: HMDB01113
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaM dectricoa m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
name: 2,4,7-decatrienoylcoa
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3f463dae_a2a3_48b3_a31d_070f8f9530ac
is: P14618
initial amount: NaN
name: PKM2
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5315

metaM c16dc e
is: SBO:0000247
name: Hexadecanedioic acid mono-L-carnitine ester
type: Species
initial amount: NaN
is: HMDB00712
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C23H42NO6 CHARGE: -1
initial concentration: 1.0

metaR HESTRATRIOLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
name: hydroxylated estrogen derivative transport
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_ef00effb_ec7a_4cf0_bdff_8362bf05b30b
has only substance units: false
name: PYCRL
is encoded by: hsa:65263
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q53H96

metaM thymd c
initial amount: NaN
type: Species
name: Thymidine
is: HMDB00273
has only substance units: false
is: CHEBI:17748
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: C00214

metaR r2118
product: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false

metaR S6TASE18ly
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR TYR3MO2
is: SBO:0000176
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
type: Reaction
fast: false
name: tyrosine 3-monooxygenase
notes: GENE_ASSOCIATION: (7054.1) or (7054.3) or (7054.2) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.16.2 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9920892 NOTES:SAB unlumped form based on PMID 10727395
kinetic law: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.2
reactant: MODEL1310110020#

metaM h r
is: CHEBI:24636
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
type: Species
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: proton

metaR r0009
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR 5ADTSTSTERONESULT
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
modifier: MODEL1310110020#
name: 5alpha-Dihydrotestosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
reversible: false

metaM so4 c
is: HMDB01448
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaR r0788
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110020#
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaR COAtn
reactant: MODEL1310110020#
name: coenzyme A transport, nuclear
product: MODEL1310110020#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

metaR r1725
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
name: Y+LAT2 Utilized transport
type: Reaction

metaM HC00250 e
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: hydrosulfide
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29919
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5659cdca_cbf8_44eb_8023_426a149c4ce6
is: Q9BQG2
initial amount: NaN
name: NUDT12
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:83594
is: SBO:0000252
type: Species

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_d36a16f8_aacd_421b_9c45_2d84e47a67ca
is: Q96CD2
is encoded by: hsa:60490
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: PPCDC
initial concentration: NaN
constant: false
is: SBO:0000252

metaR TTDCPT1
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110020#
name: carnitine O-palmitoyltransferase
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_6b525d08_ecda_43bd_abdd_90251647f56d
name: MAN2B1
constant: false
type: Species
is encoded by: hsa:4125
initial amount: NaN
is: O00754
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM eicostet c
boundary condition: false
is: HMDB02177
is: SBO:0000247
name: eicosatetranoic acid
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033

metaR TMDPK
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.2
modifier: MODEL1310110020#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
initial concentration: 1.0
name: nLc7Cer
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:26174

http://identifiers.org/biomodels.db/MODEL1310110020#_db73ec41_3d3a_4285_946f_60834907f6f1
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3029
has only substance units: false
is: SBO:0000252
name: HAGH
is: Q16775
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_0a4bc3c1_55b4_426d_9316_731b86f66fb0
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P51178
has only substance units: false
initial concentration: NaN
name: PLCD1
boundary condition: true
is encoded by: hsa:5333

metaR r1492
product: MODEL1310110020#
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: false
fast: false
kinetic law: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_51869c09_4ddd_4dcd_b142_a14b8f51ab80
is: SBO:0000252
name: PDE9A
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5152

metaR TTDCPT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176

metaR COAtm
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
name: CoA transporter
product: MODEL1310110020#
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is: SBO:0000185
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_0028dece_85b2_41ac_b7fd_e0c5b4206b80
initial amount: NaN
boundary condition: true
name: PANK2
constant: false
type: Species
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9BZ23

metaM m1mpdol L c
boundary condition: false
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28067
type: Species
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110020#_b8885e53_70a0_443a_b9f9_0c8f3336c51b
has part: P18545
type: Species
is encoded by: hsa:5147
has only substance units: false
is encoded by: hsa:5148
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial concentration: NaN
is: SBO:0000297
has part: O43924
initial amount: NaN
boundary condition: true
constant: false

metaM CE4722 e
notes: FORMULA: C38H49N6O10 CHARGE: -1 INCHI: InChI=1/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/p-1/t26-,27+,28+,29-,30+,32-/m1/s1 EHMN_ABBREVIATION: CE4722
is: C01936
constant: false
initial amount: NaN
has only substance units: false
name: beta-casomorphin (1-6)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041

metaM cbasp e
constant: false
name: N-Carbamoyl-L-aspartate
is: HMDB00828
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:32814
is: C00438
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2
boundary condition: false
is: SBO:0000247

metaM chsterol m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16113
is: HMDB00067
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
constant: false
boundary condition: false
is: SBO:0000247

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM 3hdeccoa m
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
type: Species
is: HMDB02288
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR GLUNm
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
name: glutaminase (mitochondrial)
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.5.1.2
is described by: ECO:0000269
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction

metaR MI4PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000269
fast: false
name: myo-inositol 4-phosphatase

metaR COAtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
product: MODEL1310110020#
name: CoA transport in lysosome via diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_52e37dd8_52f9_4208_b145_b4ba9d717451
has only substance units: false
boundary condition: true
initial amount: NaN
name: SUCLG1:SUCLA2
initial concentration: NaN
type: Species
has part: E5KS60
is encoded by: hsa:8803
is: SBO:0000297
constant: false

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
kinetic law: MODEL1310110020#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_f9daafa4_4d79_44e1_8f0a_3b54d4e89c8c
boundary condition: true
has only substance units: false
is: Q96M32
constant: false
name: AK7
is encoded by: hsa:122481
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DMNONCRNt
reactant: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_a74d89f4_8c6e_4181_a242_55fb2663b014
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q13123
is encoded by: hsa:3550
name: IK
constant: false
boundary condition: true

metaM hdd2coa x
is: SBO:0000247
is: CHEBI:61526
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
boundary condition: false
is: HMDB03945
has only substance units: false
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
constant: false

metaR GLCNACASE4ly
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110020#
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_0a3fc1f6_6819_46fe_9190_57d6dc3e90b2
type: Species
is encoded by: hsa:6718
initial concentration: NaN
name: AKR1D1
is: SBO:0000252
is: P51857
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM h n
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: CHEBI:24636
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_05b419b2_fd18_426f_a5d6_43668e2c75f9
name: NDUFB3
initial amount: NaN
boundary condition: true
is: Q6IB80
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4709
constant: false
initial concentration: NaN
type: Species

metaR RE3627M
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
name: RE3627
modifier: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_f05dd171_0e9c_4950_a97a_e47eec5ffa90
initial amount: NaN
name: PCYT2
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5833
is: F5H8B1
initial concentration: NaN

metaR r0797
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM CE5854 e
is: SBO:0000247
boundary condition: false
name: gama-CEHC-glucuronide
initial amount: NaN
is: HMDB02710
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
is: CHEBI:27485
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_f053bdbb_3ec9_4855_8a85_af1a838b3dd7
is encoded by: hsa:55907
type: Species
name: CMAS
boundary condition: true
has only substance units: false
is: Q8NFW8
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_45b60639_7a27_4843_af4b_4f50d749f381
boundary condition: true
is: Q8NCL4
initial amount: NaN
name: GALNT6
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:11226
has only substance units: false
is: SBO:0000252

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR BMTer L
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: B mannosyltransferase, endoplasmic reticulum
reversible: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#

metaR NDP10ex
product: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
name: nucleoside-diphosphatase (IDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4f8d2859_e7e2_4283_87bc_97f615baa7a9
is: Q53YB7
type: Species
boundary condition: true
name: COX5B
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1329
initial concentration: NaN

metaM CE2838 e
is: SBO:0000247
boundary condition: false
is: C01936
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
name: maltononaose

metaR G14T6g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176

metaM cbasp c
type: Species
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
name: N-Carbamoyl-L-aspartate
is: C00438
is: HMDB00828
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32814
has only substance units: false
constant: false
initial amount: NaN

metaM Rtotal2coa c
has only substance units: false
is: CHEBI:16199
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: C00086
name: R total 2 coenzyme A
type: Species
initial amount: NaN
is: HMDB00294

http://identifiers.org/biomodels.db/MODEL1310110020#_c4b9bcf4_6743_4ce3_a1cc_bbf378bcfdb4
has only substance units: false
is: P14555
name: PLA2G2A
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5320
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_15beaf7f_5104_4270_93f6_dc506c7bd82a
boundary condition: true
type: Species
is encoded by: hsa:412
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: STS
constant: false
has only substance units: false
is: P08842

metaR PIter
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

metaR ORNt4m
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
product: MODEL1310110020#
reversible: true
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_7a511705_310b_4e63_b77d_24bab60f9518
initial amount: NaN
name: _286297_1_c
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:286297

http://identifiers.org/biomodels.db/MODEL1310110020#_613d4880_a4d9_430e_bd81_ef67da674402
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC34A2
is: O95436
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:10568
boundary condition: true

metaR r2112
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110020#
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#

metaR RE1135C
is: SBO:0000176
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
name: RE1135
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR ACACT5p
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110020#
fast: false
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false

metaM chsterol r
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16113
has only substance units: false
constant: false
initial concentration: 1.0
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
boundary condition: false

metaR H2O2tp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: hydrogen peroxide peroxisomal transport via diffusion
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
reversible: true

metaM h l
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
is: C00080
is: CHEBI:24636

metaM ser L m
is: SBO:0000247
is: CHEBI:17115
initial amount: NaN
constant: false
name: L-serine
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187

metaM glyclt c
is: SBO:0000247
has only substance units: false
is: CHEBI:29805
name: glycolate
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
initial amount: NaN
is: HMDB00115

metaR PRASCS
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
reversible: true
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is: SBO:0000176
reactant: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6

metaM leuktrD4 e
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:28666
type: Species
name: Leukotriene D4
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080

metaR LEUKTRE4t
name: leukotriene E4 transport
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaR B3GNT310g
reversible: false
is described by: ECO:0000254
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM 2hb e
name: 2-Hydroxybutyrate
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:1148
is: HMDB00008
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r0795
type: Reaction
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110020#
name: Spontaneous reaction
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reversible: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_2fb7b06e_c5b6_4bef_bbf2_960d5cba4e3f
has only substance units: false
constant: false
initial amount: NaN
name: PDE9A
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_b3d179ac_e28c_4b6a_8dc2_cca42d46609d
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _U37519_1_c
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:U37519

metaR RE0828E
name: RE0828
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction

metaR RE2666C
type: Reaction
name: RE2666
reactant: MODEL1310110020#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:

metaR 34DHOXPEGOX
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
modifier: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction

metaM HC01603 c
initial amount: NaN
is: C00234
boundary condition: false
type: Species
name: 10-Formyltetrahydrofolate
constant: false
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

metaR FAOXC122x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_c52b5ed6_1042_41d0_956f_379c0c0b0110
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: _BE966236_1_c
boundary condition: true
is encoded by: hsa:BE966236
initial amount: NaN
is: SBO:0000252

metaM 3hodcoa c
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
boundary condition: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: HMDB13336
initial concentration: 1.0

metaM h m
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
constant: false
is: C00080
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: proton

metaR PROSTGI2tr
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Prostaglandin I2 transport (ER)
is described by: ECO:0000269
is: SBO:0000185

metaR r1495
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
type: Reaction
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1

metaR FAOXC101C102x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR r2113
product: MODEL1310110020#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR FAOXC12C12OHm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_237d1661_efe6_4b5d_bd67_7f794bbe787d
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q9UG56
name: PISD
constant: false
initial concentration: NaN
is encoded by: hsa:23761
has only substance units: false

metaR r2110
fast: false
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r1723
product: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110020#
is: SBO:0000185
modifier: MODEL1310110020#
type: Reaction
reversible: false
kinetic law: MODEL1310110020#
fast: false

metaR SPODMm
reversible: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
name: superoxide dismutase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7519265a_4ea1_4147_a8e2_4bf934833b5e
constant: false
initial amount: NaN
is encoded by: hsa:AV713053
name: _AV713053_1_m
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r0792
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
product: MODEL1310110020#

metaM 3hexdtricoa m
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02288
name: 3,7,10-hexadecatrienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c76b6e60_5c3b_47bc_99b5_c1f839a79ca9
is encoded by: hsa:9377
initial concentration: NaN
initial amount: NaN
name: COX5A
boundary condition: true
is: SBO:0000252
is: P20674
type: Species
has only substance units: false
constant: false

metaM memgacpail hs r
initial concentration: 1.0
is: CHEBI:15809
type: Species
has only substance units: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_e82c4789_bcb5_4c80_9c58_ef8de10b8447
has only substance units: false
is: P09622
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1738
type: Species
name: DLD

metaM hspg e
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
type: Species
is: CHEBI:32366
name: heparan sulfate proteoglycan
boundary condition: false
initial amount: NaN
is: HMDB02259

metaR CLS hs
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110020#
type: Reaction
fast: false
name: cardiolipin synthase (homo sapiens)

metaR ALDD2y
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110020#
reversible: false
is described by: ECO:0000000
name: aldehyde dehydrogenase (acetaldehyde, NADP)
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_50b28602_9e11_41d9_9ac5_2d31d4ae39e8
type: Species
constant: false
has only substance units: false
boundary condition: true
is: O75452
is encoded by: hsa:8608
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: RDH16

metaR r2111
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110020#

metaM 2hb c
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
boundary condition: false
constant: false
has only substance units: false
name: 2-Hydroxybutyrate

metaR r1722
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR OCOAT1m
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.8.3.5
reversible: true
modifier: MODEL1310110020#
is described by: ECO:0000269
name: 3-oxoacid CoA-transferase
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_f0911600_73f2_4edb_997f_5638c41cbd5f
constant: false
boundary condition: true
is: SBO:0000252
is: Q99884
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6534
name: SLC6A7
type: Species
initial amount: NaN

metaR COAtg
kinetic law: MODEL1310110020#
is: SBO:0000185
name: CoA transport in Golgi via diffusion
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
fast: false
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR GLYtp
kinetic law: MODEL1310110020#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: glycine passive transport to peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1c1479df_cd6e_4df7_aafc_e96f936eef0a
type: Species
constant: false
is encoded by: hsa:3157
is: Q01581
is: SBO:0000252
has only substance units: false
name: HMGCS1
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_b75d314b_cf73_4739_826c_6361253937e3
is: SBO:0000252
constant: false
name: SDHB
is encoded by: hsa:6390
type: Species
is: P21912
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a0f779a2_8e71_439c_ad97_ec950f23d8c8
constant: false
boundary condition: true
name: TXNRD1
is encoded by: hsa:7296
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q16881
is: SBO:0000252
type: Species

metaM lnlncacrn m
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: SBO:0000247
name: alpha-linolenyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB06319
type: Species

metaM kynate c
is: HMDB00715
constant: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
name: kynurenate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58454

metaR RAI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000
name: retinal isomerase (9-cis)
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110020#

metaR PYRt2r
is described by: ECO:0000269
reactant: MODEL1310110020#
fast: false
reversible: true
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
name: pyruvate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is: SBO:0000185
type: Reaction

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM 3ivcoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
name: 3-hydroxyisovalerylcoa
is: HMDB06870
type: Species
has only substance units: false
constant: false
is: C05998
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR FAOXC2031836m
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_699ca352_71ee_4503_ae6c_0ff78456dd4f
boundary condition: true
name: ADH6
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:130
is: P28332

metaR ALDD2x
product: MODEL1310110020#
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction

metaR r1493
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM eitetcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaM hLkynr c
is: CHEBI:17380
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
name: 3-hydroxy-L-kynurenine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB11631
is: SBO:0000247
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_a648e3b7_0e37_49ff_b689_a0de80ef49f3
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: DGUOK
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1716

metaM xol7a r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
boundary condition: false
constant: false
type: Species
is: CHEBI:1296
has only substance units: false
is: HMDB01496
name: 20-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110020#_3373d721_0ecb_4781_a834_86fe0c63324b
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: O14734
is encoded by: hsa:10005
initial amount: NaN
type: Species
name: ACOT8
boundary condition: true

metaM ksii core4 deg3 l
is: SBO:0000247
constant: false
is: HMDB00143
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3

metaR r2364
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
fast: false

metaM HC02213 c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:28031
has only substance units: false
constant: false

metaR NACASPAH
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.15
reversible: false
is described by: ECO:0000269
name: N-Acetyl-L-aspartate amidohydrolase
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction

metaM tetdece1crn c
notes: FORMULA: C21H39NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02014
is: SBO:0000247
constant: false
initial amount: NaN
name: tetradecenoyl carnitine
type: Species

metaM omhpal r
type: Species
initial concentration: 1.0
is: HMDB06294
name: w-hydroxypalmiticacid
boundary condition: false
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM chsterol e
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
is: CHEBI:16113

metaM elaidcrn c
is: HMDB06464
initial concentration: 1.0
name: Elaidic carnitine
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+

http://identifiers.org/biomodels.db/MODEL1310110020#_f375cdcf_36ee_43f8_95ee_262cabd4206d
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q6IBC0
boundary condition: true
is encoded by: hsa:3155
type: Species
initial amount: NaN
name: HMGCL

metaM ksi pre14 g
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2f148424_eab3_4e7c_bab3_eb112e34398f
name: SLC7A11
is encoded by: hsa:23657
is: Q9UPY5
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r0791
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176

metaR r2365
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true

metaR RE0937E
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: RE0937
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
product: MODEL1310110020#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.17.23
is described by: ECO:0000000
is: SBO:0000176

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
name: Transport reaction
fast: false
reversible: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4742a9ed_fbeb_4b88_a1a3_985be1cedeb9
initial concentration: NaN
is: O00330
type: Species
constant: false
is encoded by: hsa:8050
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: PDHX

metaR FAOXC205C184x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_cb60abb3_722b_4de2_ace1_f73eaecfcf07
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:100287639
type: Species
name: _100287639_1_c
initial amount: NaN

metaR CMPSASn
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase, nuclear

metaM ksi pre4 g
notes: FORMULA: C101H165N7O72X CHARGE: -1
constant: false
has only substance units: false
is: CHEBI:58053
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 4
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM sphmyln hs c
has only substance units: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
boundary condition: false
is: SBO:0000247
constant: false
name: sphingomyelin betaine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58216
type: Species

metaM HC02213 e
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-e3
is: SBO:0000247
is: CHEBI:28031
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
type: Species

metaR GULLACter
name: gulonolactone endoplasmic reticular transport
is described by: ECO:0000000
product: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8dfb2f27_b008_4877_a72e_4f049617fce0
boundary condition: true
name: LYZL1
is: SBO:0000252
initial amount: NaN
is: Q6UWQ5
type: Species
initial concentration: NaN
is encoded by: hsa:84569
constant: false
has only substance units: false

metaR ALCD21 L
is: SBO:0000176
modifier: MODEL1310110020#
fast: false
reversible: false
name: alcohol dehydrogenase (L-1,2-propanediol)
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM tetdece1crn e
name: tetradecenoyl carnitine
notes: FORMULA: C21H39NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB02014
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_451a079f_3dcc_4287_b1e9_9dbeb2f5c13f
name: SLC1A4
boundary condition: true
is: SBO:0000252
is: P43007
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6509
has only substance units: false

metaR r0932
product: MODEL1310110020#
type: Reaction
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
name: Transport reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR r2366
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2439
fast: false
reactant: MODEL1310110020#
reversible: false
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

metaR GALASE16ly
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
modifier: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false

metaR r1832
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110020#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000

metaR HOXG
kinetic law: MODEL1310110020#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.99.3
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is: SBO:0000176
fast: false
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
name: Heme oxygenase 1
reactant: MODEL1310110020#

metaM 1pyr5c c
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
is: CHEBI:15893
type: Species
initial concentration: 1.0
initial amount: NaN
is: C03912
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301

metaR NACHEX18ly
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR CSPG Btly
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110020#
fast: false

metaM dectricoa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
has only substance units: false
constant: false
type: Species
name: 2,4,7-decatrienoylcoa
initial amount: NaN
boundary condition: false

metaM h g
constant: false
is: CHEBI:24636
name: proton
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

metaM leuktrD4 c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
is: SBO:0000247
is: HMDB03080
constant: false
name: Leukotriene D4
has only substance units: false
type: Species
boundary condition: false

metaM CE5869 e
initial amount: NaN
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
type: Species
has only substance units: false
name: lysyl-proline
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247

metaR EX CE2916 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin exchange
type: Reaction

metaM acmana c
name: N-acetyl-D-mannosamine
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
is: CHEBI:17122
is: SBO:0000247
boundary condition: false
is: HMDB01129
type: Species
has only substance units: false
constant: false

metaR FAOXC122m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR r2367
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_90abec16_7683_48be_8289_f86dca8c7971
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q9BXS1
is encoded by: hsa:91734
name: IDI2
boundary condition: true
is: SBO:0000252

metaR r1831
is described by: ECO:0000000
modifier: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false

metaM 3hodcoa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxyoctadecanoyl-CoA
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_354b97d9_0afb_42c3_abd9_948aaf8c1363
constant: false
is: Q10472
boundary condition: true
name: GALNT1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:2589
initial concentration: NaN

metaR r2360
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_aaad4f00_f435_4947_9664_245922dcd736
name: PLCB2
boundary condition: true
is encoded by: hsa:5330
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q59F77
initial concentration: NaN
constant: false

metaR COAtr
kinetic law: MODEL1310110020#
name: COA transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110020#
reversible: true
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM octdececoa c
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: octadecenoylcoa
is: HMDB06351
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

metaR P45027A1m
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
name: Cytochrome P450 27
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false

metaM HC02202 e
is: CHEBI:57398
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR S4TASE1ly
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
reactant: MODEL1310110020#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110020#

metaR ADPtx
is: SBO:0000185
reactant: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
name: ADP transporter, peroxisomal
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

http://identifiers.org/biomodels.db/MODEL1310110020#_d429b0b8_35a7_4201_8ccc_d8309959fd88
has only substance units: false
is encoded by: hsa:125
boundary condition: true
type: Species
is encoded by: hsa:124
is: SBO:0000297
initial amount: NaN
constant: false
has part: P00325
has part: P07327
initial concentration: NaN
name: ADH1A:ADH1B

http://identifiers.org/biomodels.db/MODEL1310110020#_4561098a_d3e2_4d67_978b_004cddec5ea1
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:51079
constant: false
boundary condition: true
name: NDUFA13
initial amount: NaN
is: SBO:0000252
is: Q9P0J0

http://identifiers.org/biomodels.db/MODEL1310110020#_2a586b66_78ed_447f_973a_0fa49948eb72
is encoded by: hsa:216
name: ALDH1A1
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: P00352
is: SBO:0000252
constant: false

metaM co e
name: carbon monoxide
boundary condition: false
is: SBO:0000247
is: CHEBI:17245
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB01361
has only substance units: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaM limnen c
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15384
type: Species
constant: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
is: HMDB03375
name: limonene
is: SBO:0000247

metaR RE2677E
is: SBO:0000176
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110020#
fast: false
reversible: false
name: RE2677
product: MODEL1310110020#
type: Reaction

metaR DCSPTN1CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_99591b12_4a93_48e7_9e26_263e95e83311
is: Q6UVY6
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:26002
name: MOXD1

metaR r2361
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110020#
fast: false

metaM dump n
is: CHEBI:246422
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
initial amount: NaN
name: dUMP(2-)
boundary condition: false
constant: false
type: Species
is: HMDB01409

http://identifiers.org/biomodels.db/MODEL1310110020#_0d54c998_52d3_47b2_b318_6010e5ec0594
is: SBO:0000252
has only substance units: false
constant: false
name: MAN2A2
is: Q9P1E4
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4122

metaM gpail hs c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17049
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
constant: false
initial amount: NaN
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM hs deg22 l
initial amount: NaN
notes: FORMULA: C37H56NO35S CHARGE: -3
initial concentration: 1.0
is: HMDB02704
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:21338
boundary condition: false

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
type: Species
constant: false
is: C00080
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_255d8ee1_07fb_43a9_9ae6_cff299ced535
is: P53396
type: Species
is encoded by: hsa:47
name: ACLY
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR HESTRATRIOLte
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
reversible: true
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_b13487c2_47cb_41a2_8cce_5e9a17077caa
is encoded by: hsa:5152
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: PDE9A
initial concentration: NaN

metaR r2000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR TETHEX3COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185

metaR DCSPTN1CPT2
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine transferase
is described by: ECO:0000000

metaM 3hexdtricoa x
boundary condition: false
is: SBO:0000247
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02288
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR r2362
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d4a8c4c0_01a7_4754_8c35_a14bbc02254a
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:3067
boundary condition: true
is: P19113
has only substance units: false
type: Species
initial amount: NaN
name: HDC

metaM HC00250 c
initial concentration: 1.0
constant: false
is: CHEBI:29919
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
name: hydrosulfide
is: SBO:0000247

metaM sphmyln hs g
has only substance units: false
name: sphingomyelin betaine
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
is: CHEBI:58216
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_76ac60cc_a483_4c33_9564_729dd5ee4e6e
is encoded by: hsa:6391
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: SDHC
boundary condition: true
is: Q99643
initial concentration: NaN

metaM lnlncacrn c
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
constant: false
is: HMDB06319
is: SBO:0000247
initial concentration: 1.0
type: Species
name: alpha-linolenyl carnitine

metaM chsterol l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
name: cholesterol
is: CHEBI:16113
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00067

metaM HC02202 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57398
name: prostaglandin A1(1-)
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
has only substance units: false

metaM acac c
constant: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: HMDB00060
is: CHEBI:13705
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: acetoacetate
is: SBO:0000247

metaM eicostet e
notes: FORMULA: C20H31O2 CHARGE: -1
type: Species
is: HMDB02177
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: eicosatetranoic acid
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36033

metaM C02528 r
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
is: SBO:0000247
initial amount: NaN
constant: false
name: chenodeoxycholate
has only substance units: false

metaM co c
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB01361
name: carbon monoxide
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245

metaM sphgn c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: sphinganine(1+)
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57817
is: HMDB00269

http://identifiers.org/biomodels.db/MODEL1310110020#_87ff9d25_5bea_4f55_9a2a_a75a729108f9
has only substance units: false
boundary condition: true
name: PNPO
is encoded by: hsa:55163
is: SBO:0000252
initial amount: NaN
is: Q9NVS9
constant: false
type: Species
initial concentration: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR TETPENT6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
product: MODEL1310110020#
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
fast: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR FAOXC101C102m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR INSTt4 2
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
name: inositol transport via sodium symport
type: Reaction
fast: false
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000006

metaR r1836
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110020#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR COAtp
fast: false
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1a1ebdbc_dee1_4167_a071_d1326584b5e2
name: MDH2
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P40926
initial amount: NaN
is encoded by: hsa:4191
has only substance units: false
type: Species

metaM limnen e
boundary condition: false
initial amount: NaN
is: CHEBI:15384
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
is: HMDB03375
is: SBO:0000247
name: limonene

http://identifiers.org/biomodels.db/MODEL1310110020#_5ad5123b_e27a_4e85_b4ec_14a31ae995b3
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: SLC16A10
is encoded by: hsa:117247
is: Q8TF71
is: SBO:0000252
initial amount: NaN

metaR r2363
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110020#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR EHGLATm
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reversible: false
reactant: MODEL1310110020#
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
product: MODEL1310110020#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110020#
is: SBO:0000176

metaR FACOAL40im
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.2
product: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD
name: fatty-acid--CoA ligase (butanoate), mitochondrial
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269

metaM h c
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
name: proton
type: Species
is: C00080
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110020#_afabcf08_2320_4441_bcf3_15bf2fae3609
name: DPYS
type: Species
initial amount: NaN
is: Q14117
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1807

http://identifiers.org/biomodels.db/MODEL1310110020#_227c6991_8d64_402a_bcb0_ce0967fa13dc
is: Q9UBX3
name: SLC25A10
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1468
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM nformanth c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:18410
constant: false
name: N-formylanthranilate
initial amount: NaN
notes: FORMULA: C8H6NO3 CHARGE: -1 INCHI: InChI=1S/C8H7NO3/c10-5-9-7-4-2-1-3-6(7)8(11)12/h1-5H,(H,9,10)(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC01553 EHMN_ABBREVIATION: C05653
is: HMDB04089

metaM hspg l
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01993
initial amount: NaN
is: CHEBI:17899
type: Species
name: heparan sulfate proteoglycan
boundary condition: false

metaR AMPtp
kinetic law: MODEL1310110020#
name: AMP transporter, peroxisome
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9d311fe5_0ebe_4f0a_8241_2a5307561ec9
name: NOS3
type: Species
is: A0S0A7
is encoded by: hsa:4846
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX appnn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (+)-alpha-Pinene exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_40eec35c_b750_4cd8_b4ba_f7b3ca355932
is: P31937
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:11112
name: HIBADH
initial concentration: NaN
has only substance units: false

metaR GALNTg
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.41
kinetic law: MODEL1310110020#
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110020#
type: Reaction
fast: false
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_cff3fec8_9070_45c1_918e_57e2257fee9e
is encoded by: hsa:55089
constant: false
type: Species
name: SLC38A4
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q969I6
has only substance units: false
boundary condition: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_02b1d795_c538_46d8_84c2_1cf312f9c3d1
is encoded by: hsa:728226
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: _728226_1_e
initial concentration: NaN
type: Species
boundary condition: true

metaR BILIRUBtr
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110020#

metaR ITCOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
is described by: ECO:0000212
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110020#

metaR FAOXC13C11m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_508743b2_7b06_4ef2_a361_825edb540b65
is encoded by: hsa:54344
has only substance units: false
boundary condition: true
is: Q9P2X0
is: SBO:0000252
constant: false
name: DPM3
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2335
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true

metaR FAOXC181C161x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaM 3hexdtetcoa x
constant: false
name: 3,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR FACOAL80i
is described by: ECO:0000269
modifier: MODEL1310110020#
name: fatty-acid--CoA ligase (octanoate)
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110020#

metaM thmpp c
initial amount: NaN
is: HMDB01372
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: C00068
name: Thiamine diphosphate
has only substance units: false
is: SBO:0000247
is: CHEBI:45931
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaR r0909
product: MODEL1310110020#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Transport reaction
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

metaR DCSPTN1COAtx
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
name: fatty acid intracellular transport
reversible: true

metaR ALATHRNaEx
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reversible: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110020#
type: Reaction

metaM tetdecdicoa x
is: HMDB02288
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
is: CHEBI:61648
is: SBO:0000247
name: Type IIIAb
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR MI14PP
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.57
name: inositol-1,4-bisphosphate 1-phosphatase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_eab95abe_ff1c_49d9_8bab_852fa941b6cf
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1109
is: P17516
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: AKR1C4

metaR r2334
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0629
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.4.1
is version of: http://identifiers.org/ec-code/3.6.1.22
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_334f1115_6330_454d_85c3_1ebc8299f613
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O00624
name: SLC17A2
is encoded by: hsa:10246
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_27be4526_5f3e_4479_89b9_f46f210d2d8e
is: P13804
initial amount: NaN
type: Species
name: ETFA
initial concentration: NaN
constant: false
is encoded by: hsa:2108
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM tetdece1coa c
is: HMDB05066
constant: false
name: tetradecenoylcoa
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_cc4cbdca_7631_4acb_aa2b_e72ef2b9c3e5
boundary condition: true
type: Species
name: RDH12
is encoded by: hsa:145226
constant: false
has only substance units: false
initial concentration: NaN
is: Q96NR8
is: SBO:0000252
initial amount: NaN

metaR HOCDACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM 3mldz c
is: CHEBI:28104
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB04181
type: Species
name: 1-methylimidazole-4-acetaldehyde

metaM cs e deg4 l
initial amount: NaN
is: CHEBI:15748
boundary condition: false
type: Species
is: HMDB00127
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H46NO38S4 CHARGE: -5

metaR r0908
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110020#

metaM g3m8masn r
is: C05873
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM cdp n
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58069
initial amount: NaN
name: CDP(3-)
constant: false
is: HMDB01546
has only substance units: false

metaR UDPGD
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.22
name: UDPglucose 6-dehydrogenase
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is described by: ECO:0000304
fast: false
reversible: false
product: MODEL1310110020#
type: Reaction

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_07ff2afd_2d7f_4405_bf51_56446d460d9b
constant: false
is: Q6TCH8
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10873
type: Species
name: ME3
initial amount: NaN

metaR EX decdicrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR r2333
reactant: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_50732e90_54a7_4b09_80ef_b7b94797d102
constant: false
has only substance units: false
is: Q71UM8
is: SBO:0000252
name: ADCY2
is encoded by: hsa:108
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM ksii core4 pre7 g
constant: false
is: HMDB00175
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00130
type: Species
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_56196e39_2912_4c8b_b4ff_06e6df190b26
initial concentration: NaN
is encoded by: hsa:6536
type: Species
is: P48067
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: SLC6A9
initial amount: NaN

metaR 41R2A1H12BOOX
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110020#
is described by: ECO:0000269
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR r0488
reversible: true
reactant: MODEL1310110020#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

metaR r0907
is: SBO:0000185
type: Reaction
reversible: true
name: Active transport
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false

metaR ALOX52
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
name: Arachidonate 5-lipoxygenase
modifier: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764

metaM pa hs c
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
type: Species
is: CHEBI:57739
constant: false
is: SBO:0000247
name: phosphatidate(2-)
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_f58e5af5_7d24_40a2_aadd_453a9c9259b7
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GMPR2
initial amount: NaN
is encoded by: hsa:51292
is: Q86T14

metaR CO2t
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
name: CO2 transporter via diffusion

metaR HDDACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r2332
fast: false
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaM cdp m
type: Species
is: HMDB01546
is: SBO:0000247
boundary condition: false
name: CDP(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR GPIAT
fast: false
name: glucosaminylphosphatidyl inositol acetyltransferase
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_11159031_3d79_4252_b1f2_38bd15fd1ab5
is encoded by: hsa:220
initial amount: NaN
constant: false
name: ALDH1A3
is: P47895
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction

metaM dheas e
boundary condition: false
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
type: Species
is: CHEBI:57905
initial concentration: 1.0
is: HMDB01032
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_650b78f4_389c_46b5_a427_071c02b22fef
is: P45954
is: SBO:0000252
name: ACADSB
is encoded by: hsa:36
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR GALASE12ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110020#
name: beta-galactosidase, lysosomal
product: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_199d466d_d637_4d0e_89b5_035c7db0c2ae
has part: P05496
is encoded by: hsa:516
has part: P56385
has only substance units: false
is encoded by: hsa:10632
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6IBB3
is encoded by: hsa:9551
is encoded by: hsa:10476
is encoded by: hsa:4905
is encoded by: hsa:522
initial concentration: NaN
has part: A0PJH2
type: Species
has part: Q08ET0
has part: O75964
constant: false
has part: P46459
initial amount: NaN
is encoded by: hsa:521
boundary condition: true
is encoded by: hsa:515

metaR BTNPLm
is: SBO:0000176
product: MODEL1310110020#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism

http://identifiers.org/biomodels.db/MODEL1310110020#_85efe0b3_7418_4866_9736_dbede02f1db4
name: VNN2
initial amount: NaN
is encoded by: hsa:8875
constant: false
is: O95498
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM 3dsphgn c
is: HMDB01480
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
has only substance units: false
boundary condition: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: SBO:0000247
is: CHEBI:58299
type: Species
initial concentration: 1.0
constant: false

metaM 3odcoa m
type: Species
has only substance units: false
is: HMDB03939
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0
name: 3-Oxodecanoyl-CoA
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28528

metaR FAOXC185C164m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_08cfa98c_a4a0_4fc5_833f_6e420a81bb4d
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: Q9NZJ6
initial amount: NaN
is: SBO:0000252
name: COQ3
boundary condition: true
is encoded by: hsa:51805

metaM crn x
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
name: L-Carnitine
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00062
is: C00318
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_67b8b177_7bb1_4590_a54e_7ff88ba5f8c1
is: SBO:0000252
is encoded by: hsa:51
initial concentration: NaN
is: B4DK61
boundary condition: true
type: Species
name: ACOX1
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6930f83c_e430_4bc3_ab04_26c281b18f4d
is: Q53HE2
initial concentration: NaN
has only substance units: false
boundary condition: true
name: TPI1
type: Species
is encoded by: hsa:7167
initial amount: NaN
constant: false
is: SBO:0000252

metaR FAOXC141C121x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM tethex3coa c
name: tetracosahexaenoyl coenzyme A
is: C16168
is: SBO:0000247
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
is: HMDB06243
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205478
initial amount: NaN
type: Species

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
has only substance units: false
is: CHEBI:15347
name: Type IIIAb
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01659
initial amount: NaN
type: Species
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0

metaR PI45P3K
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_6f23bc96_1923_466b_8579_6ebb2a153b3d
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _F23536_1_m
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:F23536
has only substance units: false

metaR BTNDm
kinetic law: MODEL1310110020#
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction

metaM fald c
is: CHEBI:16842
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
name: formaldehyde
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01426
boundary condition: false

metaM glc D e
constant: false
boundary condition: false
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: D-glucose
is: CHEBI:4167
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_ed100205_872e_4f7d_aa73_d99d11a2b176
is encoded by: hsa:H17063
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _H17063_1_m
has only substance units: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1078
reactant: MODEL1310110020#
reversible: false
name: Vesicular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM 3ddecdicoa x
name: 3,6-dodecadienoylcoa
is: C05280
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB03952
constant: false
boundary condition: false

metaM gacpail hs c
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:61548
is: C00092
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01401
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_bfaf499b_a249_4401_b96d_451c22b2e559
is: P17735
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: TAT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6898

metaM dtmp c
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00364
initial amount: NaN
is: SBO:0000247
is: HMDB01227
name: dTMP
is: CHEBI:26999

http://identifiers.org/biomodels.db/MODEL1310110020#_32284b4e_6569_4603_8cde_fc8fc0a03849
initial concentration: NaN
is encoded by: hsa:84264
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: HAGHL

http://identifiers.org/biomodels.db/MODEL1310110020#_b4108a41_e0bd_4c91_9fad_5bbbf5fb8501
initial concentration: NaN
is: Q6FIH7
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:516
name: ATP5G1

http://identifiers.org/biomodels.db/MODEL1310110020#_05152333_5318_4009_a923_e8369449eb4a
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O43924
constant: false
is encoded by: hsa:5147
name: PDE6D
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_5d038951_065a_4099_ae13_c45f312cfc7d
is: SBO:0000252
name: DCK
initial amount: NaN
constant: false
is encoded by: hsa:1633
initial concentration: NaN
boundary condition: true
is: P27707
has only substance units: false
type: Species

metaR NADHtru
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: NADH transporter, endoplasmic reticulum
reversible: false

metaR GALK
name: galactokinase
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.6
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_db8a8c40_7df7_42db_b392_c2f9f06b8ba4
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: P18545
is: SBO:0000252
has only substance units: false
name: PDE6G
is encoded by: hsa:5148

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR LPASE
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
fast: false
name: lysophospholipase
is version of: http://identifiers.org/ec-code/3.1.1.5
is described by: ECO:0000000
product: MODEL1310110020#

metaM hestratriol r
name: 4,17 dihydroxy estradiol
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM CE2420 m
is: CHEBI:28387
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r2338
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
type: Reaction

metaR FAOXC163C142x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaR G12MT2 L
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
fast: false
type: Reaction
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
reactant: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_62add52c_c205_4458_9b5d_09384508490e
initial concentration: NaN
name: ASRGL1
initial amount: NaN
is: Q7L266
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:80150
is: SBO:0000252

metaM air c
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: C03373
is: CHEBI:58592
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
constant: false
is: HMDB01235

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
is: SBO:0000247
constant: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_fc530389_60d7_43fa_82bb_ec45d19acd99
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AL525798_1_c
has only substance units: false
is encoded by: hsa:AL525798
constant: false
boundary condition: true

metaR FAOXC81C61x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR r0339
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.22
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9356203b_041e_4354_9d4e_f5222e16305c
name: GALNT11
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B3KWF4
is: SBO:0000252
constant: false
is encoded by: hsa:63917
type: Species

metaR SRTNt6 2 r
is: SBO:0000185
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
is: CHEBI:15347
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01659
name: Type IIIAb
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR ACGAMtly
name: N-acetyl-glucosamine lysosomal efflux
reversible: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM hpdcacrn m
name: heptadecanoyl carnitine
is: SBO:0000247
is: HMDB06210
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_b8868640_d4f2_472a_9432_d38dedd55c3a
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: _AI539321_1_c
is encoded by: hsa:AI539321
has only substance units: false
type: Species

metaM dtmp e
name: dTMP(2-)
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01227
is: CHEBI:26999
constant: false

metaM mi14p c
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
constant: false
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
initial amount: NaN
is: CHEBI:58282
initial concentration: 1.0
is: SBO:0000247

metaR r0483
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_6af35fae_4aeb_42a1_a961_0836dc9d127d
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2977
has part: P33402
name: GUCY1A2:GUCY1B3
is encoded by: hsa:2983
has only substance units: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
has part: Q02153

metaM hs deg1 l
constant: false
type: Species
initial amount: NaN
name: heparan sulfate, degradation product 1
is: HMDB01352
is: SBO:0000247
has only substance units: false
is: CHEBI:17180
boundary condition: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
initial concentration: 1.0

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_ace70cf6_16a9_41a5_9a05_028f1d221578
is encoded by: hsa:92483
constant: false
boundary condition: true
initial amount: NaN
is: Q9BYZ2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: LDHAL6B
type: Species

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:28938
constant: false
initial amount: NaN
has only substance units: false
is: C01342
is: HMDB00051
initial concentration: 1.0
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110020#_1c920ae6_b134_49e1_bf43_a1d37b5baa4b
initial amount: NaN
name: ECI1
is: P42126
has only substance units: false
constant: false
is encoded by: hsa:1632
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR MANtly
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
is described by: ECO:0000000
name: mannose efflux from lysosome

http://identifiers.org/biomodels.db/MODEL1310110020#_2aa55bf4_70be_4408_bbb5_91e525bcd467
is: SBO:0000252
initial amount: NaN
constant: false
is: O00154
boundary condition: true
has only substance units: false
type: Species
name: ACOT7
initial concentration: NaN
is encoded by: hsa:11332

metaR FPGS6m
modifier: MODEL1310110020#
type: Reaction
reversible: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: folylpolyglutamate synthetase (DHF), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110020#_d992f9c6_0919_4948_8234_66928c8a0c02
constant: false
type: Species
is: Q16760
boundary condition: true
initial amount: NaN
name: DGKD
is: SBO:0000252
is encoded by: hsa:8527
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a7cc4724_d1af_4046_b249_7ae7b0ab4415
is: Q9UI40
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25769
name: SLC24A2
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3f87449e_7468_41b5_87ef_7970c66bf532
initial concentration: NaN
is: P48728
initial amount: NaN
is: SBO:0000252
name: AMT
is encoded by: hsa:275
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM Rtotal3 e
is: CHEBI:3554
constant: false
is: HMDB00244
is: SBO:0000247
is: C00255
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: R total 3 position
notes: FORMULA: CO2FULLR3 CHARGE: -1
initial amount: NaN

metaM ksii core2 deg2 l
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 2
is: CHEBI:12936
is: HMDB00143
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaM 3hexdcrn c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
is: SBO:0000247
initial amount: NaN
is: HMDB13336
notes: FORMULA: C23H45NO5 CHARGE: 0

metaR APNNOXte
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: xenobiotic transport
reactant: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
product: MODEL1310110020#
reversible: true

metaR AACOAT
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
type: Reaction
product: MODEL1310110020#
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
name: Acetoacetyl-CoA:acetate CoA-transferase

metaM 4nphsf e
is: CHEBI:35422
is: SBO:0000247
initial amount: NaN
is: HMDB06492
initial concentration: 1.0
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
has only substance units: false
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_43e4d833_a50b_450b_a197_609a38c88e73
type: Species
is encoded by: hsa:221
name: ALDH3B1
initial concentration: NaN
constant: false
initial amount: NaN
is: P43353
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c216eeee_1c46_44e9_acde_8a7a0ed7fb28
is encoded by: hsa:3422
has only substance units: false
type: Species
initial amount: NaN
name: IDI1
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q13907

metaR ADNt
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110020#
name: adenosine facilated transport in cytosol
reversible: true
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_7037054d_d792_4f49_b302_222a4219b50e
boundary condition: true
constant: false
name: EHHADH
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1962
is: Q9NY65

http://identifiers.org/biomodels.db/MODEL1310110020#_54a00be2_04c0_437c_b952_3af8323e4b1d
is encoded by: hsa:55753
name: OGDHL
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9ULD0

http://identifiers.org/biomodels.db/MODEL1310110020#_110f1eff_934f_4359_bfbd_5cf44fc5ba65
initial amount: NaN
initial concentration: NaN
type: Species
name: ATP5J
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:522
has only substance units: false

metaM glc D c
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
has only substance units: false
is: CHEBI:4167
initial concentration: 1.0
type: Species
name: D-glucose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_35ccf784_ce72_40ec_8ab4_6616ff969f0d
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
initial concentration: NaN
constant: false
has part: Q86U05
type: Species
initial amount: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7beb0590_804d_412b_a6c3_6fd196ffddd3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:218
is: P30838
name: ALDH3A1
initial amount: NaN
has only substance units: false

metaM CE5236 c
is: HMDB03952
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28002
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
type: Species
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_bc8a13bf_56e9_4bd0_8393_c2dff80865c4
name: SDR16C5
type: Species
has only substance units: false
is encoded by: hsa:195814
constant: false
initial concentration: NaN
boundary condition: true
is: B3KT84
initial amount: NaN
is: SBO:0000252

metaM crm hs r
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
name: N-acylsphingosine
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR DESAT24 1
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110020#
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR r0779
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR ACGALtlg
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: N-acetyl-galactosamine intracellular transport
product: MODEL1310110020#
is described by: ECO:0000000

metaR GLCURter
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: glucuronate endoplasmic reticular transport

metaR INSt4
is: SBO:0000185
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
product: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
reversible: false
name: inosine transport in via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110020#_b19911bc_c1d0_434d_8c46_608cceaf7f1c
is encoded by: hsa:157570
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ESCO2
initial amount: NaN
constant: false
is: Q56NI9

metaR FAOXC142C122x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaR MI134PP
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
name: inositol-1,3,4-trisphosphate 1-phosphatase
is described by: ECO:0000269
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.57
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_639c4d48_870b_43bc_9c0b_d8601ad09a8d
name: NDUFV3
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4731
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: P56181

http://identifiers.org/biomodels.db/MODEL1310110020#_fe1c4ecd_f533_492d_89de_9b8f13ed28c4
is: P50053
initial concentration: NaN
constant: false
name: KHK
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3795
is: SBO:0000252
has only substance units: false

metaM CE2416 x
initial concentration: 1.0
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
is: CHEBI:57923
name: (2R,6S,10S)-pristanate
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaR SERALANaEx
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
product: MODEL1310110020#
reversible: false
type: Reaction
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_0fcc02c3_0df1_4bea_afc6_fbbff063e772
initial amount: NaN
is encoded by: hsa:AGPAT7
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _AGPAT7_1_c

http://identifiers.org/biomodels.db/MODEL1310110020#_93646830_2255_4d3a_957c_6b88d38c75cb
has only substance units: false
initial concentration: NaN
is: P30519
name: HMOX2
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3163

http://identifiers.org/biomodels.db/MODEL1310110020#_49064025_5086_4bc1_a0ee_30a804c07280
name: PDE3A
is: Q14432
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5139
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaM 3hexdtetcoa m
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB02288
initial amount: NaN
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaR S6T5g
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR HTDCACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR DTTPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
name: dTTP diffusion in nucleus
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110020#

metaR ETF
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
name: electron transfer flavoprotein
reversible: false
type: Reaction

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1e4ca339_8b76_49c5_9820_4c1059cd2084
type: Species
boundary condition: true
is encoded by: hsa:3032
is: P55084
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HADHB

metaM ala L c
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16977

metaR C9BRxtc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9d17ae14_dbb3_4497_a307_3710c2dc052c
initial concentration: NaN
is: O95395
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: GCNT3
constant: false
is encoded by: hsa:9245
is: SBO:0000252

metaR HDECEACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR PAIL HStn
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM ala L e
boundary condition: false
constant: false
is: HMDB00161
type: Species
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16977
initial concentration: 1.0

metaM C02528 e
is: HMDB00518
name: chenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
initial amount: NaN
type: Species

metaR PLA2 2e
is: SBO:0000176
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
name: phospholipase A2
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
reversible: false

metaM ura e
name: uracil
is: CHEBI:17568
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
type: Species

metaM m2mpdol L c
is: CHEBI:28049
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0208
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.4.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
fast: false
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000

metaM gthox c
constant: false
boundary condition: false
type: Species
is: CHEBI:58297
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
has only substance units: false
is: SBO:0000247
is: C00127
initial amount: NaN
name: Oxidized glutathione

metaR 2HCO3 NAt
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is described by: ECO:0000269
fast: false
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185

metaR CMPACNAtn
kinetic law: MODEL1310110020#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: CMP-Sia nuclear export
type: Reaction
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9d15a3ae_4a23_43da_9d4e_47df6f31cb80
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3291
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: HSD11B2
initial concentration: NaN
is: P80365

metaR S6T17g
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
type: Reaction

metaR PTCRTD
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#
name: diffusion of putriscine into the endothelial cells
fast: false
reactant: MODEL1310110020#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.

metaR PPCOACm
name: Propionyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
reversible: false
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.3

metaR CYSALANaEx
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
is: SBO:0000185
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)

metaR DMATTx
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
name: dimethylallyltranstransferase
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110020#

metaM galside hs g
has only substance units: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
constant: false
is: CHEBI:12947
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_bc6d93a5_9226_4193_9154_3fec996d567b
boundary condition: true
is encoded by: hsa:107
has only substance units: false
initial concentration: NaN
is: Q08828
type: Species
initial amount: NaN
is: SBO:0000252
name: ADCY1
constant: false

metaR LNELDCt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
product: MODEL1310110020#
is described by: ECO:0000000
fast: false

metaM c10dc c
is: SBO:0000247
boundary condition: false
has only substance units: false
name: sebacoyl carnitine
notes: FORMULA: C17H30NO6 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: HMDB00651
constant: false
type: Species

metaM 3hdcoa m
name: (S)-3-Hydroxydecanoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM dheas c
boundary condition: false
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial concentration: 1.0
is: HMDB01032
constant: false
initial amount: NaN
is: SBO:0000247
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
has only substance units: false
is: CHEBI:57905

metaR 4ABUTtm
reversible: true
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
name: 4-aminobutanoate mitochondrial transport via diffusion

metaM 2mbcoa m
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
constant: false
is: HMDB01041
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM lpam m
boundary condition: false
is: SBO:0000247
is: HMDB00962
type: Species
constant: false
is: CHEBI:17460
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
name: lipoamide

metaM xol7aone r
constant: false
type: Species
is: CHEBI:17899
initial amount: NaN
is: SBO:0000247
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
has only substance units: false

metaR C140CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM doco13ac e
name: docosenoic acid (C22:1)
boundary condition: false
notes: FORMULA: C22H41O2 CHARGE: -1
type: Species
is: SBO:0000247
constant: false
is: HMDB02068
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM g2m8mpdol L r
initial amount: NaN
is: C05870
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
has only substance units: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM C02528 c
initial amount: NaN
is: HMDB00518
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
is: CHEBI:36234
type: Species
constant: false
name: chenodeoxycholate

http://identifiers.org/biomodels.db/MODEL1310110020#_b2ee3992_e462_427c_9a42_de873b8f875a
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:55350
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: VNN3

metaM ksii core4 deg4 l
is: HMDB00812
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 4
has only substance units: false
type: Species
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: CHEBI:16953

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM hdd2crn c
has only substance units: false
is: HMDB06317
is: SBO:0000247
constant: false
name: trans-Hexadec-2-enoyl carnitine
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+

metaR ELAIDt
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110020#
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction

metaM ddsmsterol r
type: Species
constant: false
name: 7-dehydrodesmosterol
is: SBO:0000247
is: CHEBI:27910
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: HMDB03896
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM galside hs e
type: Species
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
constant: false
is: CHEBI:12947
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_7a919b4f_e56c_4a9f_95f5_8e3ae87974a1
initial amount: NaN
name: PPCDC
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q96CD2
constant: false
is encoded by: hsa:60490
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_00faa398_b008_43b7_8058_476c1dffc26e
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: B4DK61
is: SBO:0000252
name: ACOX1
type: Species
has only substance units: false
is encoded by: hsa:51

metaR TTDCAFATPc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM cdpdag hs c
has only substance units: false
is: CHEBI:58332
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
constant: false
initial concentration: 1.0
name: CDP-diacylglycerol(2-)

metaR FAOXC141C121m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_0549d539_73c3_445b_b124_eb9a3056e6ea
type: Species
has only substance units: false
name: ACOT2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10965
initial amount: NaN
is: SBO:0000252
constant: false
is: P49753

metaR TRPHYDRO2
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.16.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
modifier: MODEL1310110020#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110020#
is described by: ECO:0000269

metaR r0330
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#

metaR H3ETer
kinetic law: MODEL1310110020#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
fast: false
product: MODEL1310110020#
modifier: MODEL1310110020#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110020#

metaR r0780
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5d139999_e512_434e_8983_e9433add4a46
is: P24310
type: Species
constant: false
name: COX7A1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1346
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_c9717a77_9c53_4df1_b0b2_9ad5c62cede0
boundary condition: true
constant: false
has only substance units: false
name: SLC23A1
is encoded by: hsa:9963
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM ksi deg14 l
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 14
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
constant: false

metaM HC01397 m
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
type: Species
is: CHEBI:27402
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

metaM cdpdag hs m
initial concentration: 1.0
type: Species
is: CHEBI:58332
initial amount: NaN
name: CDP-diacylglycerol(2-)
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_cbf3508f_20f5_4b26_8940_ea608b5a8d07
is: Q9H936
has only substance units: false
is encoded by: hsa:79751
constant: false
is: SBO:0000252
name: SLC25A22
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM xylt c
has only substance units: false
is: HMDB02917
constant: false
is: SBO:0000247
initial amount: NaN
name: xylitol
type: Species
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
boundary condition: false

metaR CSNt
modifier: MODEL1310110020#
reversible: true
is described by: ECO:0000269
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is: SBO:0000185
name: cytosine transport via facilated diffusion

http://identifiers.org/biomodels.db/MODEL1310110020#_9d732021_7764_4c65_af7c_3f85082151f7
initial amount: NaN
is: O00443
boundary condition: true
constant: false
name: PIK3C2A
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5286
has only substance units: false

metaM naglc2p L c
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:18278
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
boundary condition: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM xol7aone m
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
boundary condition: false
is: CHEBI:17899
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN

metaR STRDNCCPT2
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
name: carnitine transferase
reversible: false

metaM c10dc x
is: SBO:0000247
initial concentration: 1.0
is: HMDB00651
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: sebacoyl carnitine

metaM galside hs c
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:12947
constant: false
name: D-galactosyl-N-acylsphingosine

metaR NACHEX11ly
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:33190
is: HMDB11111
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 3-oxopropanoate

metaR PI5P4K
is: SBO:0000176
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD
reversible: false
kinetic law: MODEL1310110020#
name: phosphatidylinositol-5-phosphate 4-kinase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_55eef238_a3c8_482c_8c57_7c0ef0b2a129
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:226
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDOA
is: P04075
boundary condition: true

metaR FAOXC121x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110020#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
type: Reaction

metaM k e
type: Species
has only substance units: false
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
constant: false
boundary condition: false
initial concentration: 1.0
name: potassium
is: HMDB00586
initial amount: NaN
is: SBO:0000247

metaM cala c
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: N-carbamoyl-beta-alaninate
is: HMDB00026
is: CHEBI:11892
is: SBO:0000247
constant: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_eae6300b_7b86_4421_8e99_bc2b9ddd7ac9
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: P33261
is encoded by: hsa:1557
name: CYP2C19
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR S2TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reversible: false
is described by: ECO:0000000
fast: false
name: iduronate-2-sulfatase, lysosomal
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176

metaR TETTET6t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
fast: false
name: fatty acid transport via diffusion

metaR C8CRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR STRDNCCPT1
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

metaR EX c81crn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaM pmtcoa m
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: C00154
is: CHEBI:57379
initial concentration: 1.0
type: Species
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110020#_76914992_0563_407e_abdc_2789ebaf6cc6
name: TXNRD1
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7296
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_8807eb79_0271_40e2_950a_7dbc89b9318d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1798
is: Q9H3H5
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: DPAGT1
has only substance units: false

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: C04383
boundary condition: false
constant: false
is: SBO:0000247

metaR MECOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000212
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false

metaR MAOX
reactant: MODEL1310110020#
is described by: ECO:0000304
name: Methylamine oxidase
modifier: MODEL1310110020#
is: SBO:0000176
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB

metaR FAOXC81C61m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r0782
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
fast: false
reactant: MODEL1310110020#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR GLCNACASE1ly
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false

metaR DMHPTCRNt
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: 2,6 dimethylheptanoyl crn transport
product: MODEL1310110020#

metaR MI1PS
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
modifier: MODEL1310110020#
name: myo-Inositol-1-phosphate synthase
is version of: http://identifiers.org/ec-code/5.5.1.4
kinetic law: MODEL1310110020#
fast: false
reversible: false

metaR C101CRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR S6TASE22ly
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110020#
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110020#

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true

metaM mi14p n
constant: false
is: HMDB00968
is: CHEBI:58282
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR NDPK10n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_8e52df40_0def_49aa_805a_83f7a91d5a8e
is encoded by: hsa:2182
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q5JWV8
name: ACSL4
boundary condition: true
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_9221f704_c188_4c49_8947_ad66acd7a38d
type: Species
is encoded by: hsa:AV717590
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: _AV717590_1_m

metaR G14T7g
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110020#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR ESTSULT
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.8.2.4
reversible: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000269
name: Estrogen sulfotransferase
type: Reaction
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.8.2.1

metaR DCSPTN1CRNt
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: transport into the mitochondria (carnitine)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7809f208_5146_4e9d_8a08_df3afa5ce370
is encoded by: hsa:5207
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PFKFB1
boundary condition: true
constant: false
is: P16118

metaR MECOAS1m
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
product: MODEL1310110020#
modifier: MODEL1310110020#
name: mesaconate--CoA ligase (GDP-forming)
type: Reaction
reactant: MODEL1310110020#

metaR TYMSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_a9a40965_0de4_41d3_8cb3_04af2a3feb72
type: Species
is: B3KN25
initial amount: NaN
name: CEPT1
constant: false
is encoded by: hsa:10390
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM decdicrn c
name: decadienoyl carnitine
has only substance units: false
is: HMDB13325
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C17H29NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR LTD4DP
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: true
name: Leukotriene D4 dipeptidase
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

metaR r2142
kinetic law: MODEL1310110020#
type: Reaction
fast: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_2920422b_7cf6_4c68_94bc_1fd8b3d17625
initial amount: NaN
has only substance units: false
is encoded by: hsa:65985
initial concentration: NaN
name: AACS
boundary condition: true
is: SBO:0000252
is: Q86V21
constant: false
type: Species

metaM appnn e
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
name: (+)-alpha-pinene
is: HMDB06525
is: CHEBI:28261
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_3366fa06_1a77_47fa_ac40_f7814fda76e0
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P07864
boundary condition: true
name: LDHC
is encoded by: hsa:3948
has only substance units: false
initial amount: NaN

metaR r2443
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
kinetic law: MODEL1310110020#

metaM pydam c
has only substance units: false
constant: false
is: HMDB01431
initial amount: NaN
type: Species
boundary condition: false
is: C00534
name: Pyridoxamine
initial concentration: 1.0
is: CHEBI:57761
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: SBO:0000247

metaR r0784
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
reversible: true
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#

metaR CMPACNAtg
is: SBO:0000185
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110020#
name: CMP-Sia Golgi transport via CMP antiport
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_9ebb0e32_d5c8_44bd_a9ba_3c23dc9a682f
boundary condition: true
is: SBO:0000252
name: SLC35D2
is: Q76EJ3
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11046
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_47a56572_d0df_4c0f_b9d3_83e21034471d
boundary condition: true
is: SBO:0000252
is: Q96PL7
initial concentration: NaN
constant: false
is encoded by: hsa:9154
initial amount: NaN
name: SLC28A1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_ff9dee14_878b_4d13_85e4_5ad7954a97da
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PDE8A
is: SBO:0000252
is encoded by: hsa:5151
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4587cfd3_ceac_407e_88a6_c6d054813028
is: O94777
is: SBO:0000252
type: Species
name: DPM2
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8818
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_dcd1d449_61c4_43af_834a_852bc5946eb2
is: SBO:0000252
name: _LOC647190_1_c
is encoded by: hsa:LOC647190
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR FAOXC16DCr
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM HC01408 m
is: CHEBI:27648
is: SBO:0000247
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
name: 3-Oxohexanoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
product: MODEL1310110020#
fast: false
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: Transport of (R)-Pantothenate

metaR H8TAer
fast: false
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
name: H8 transamidase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR r0630
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR RE3628M
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110020#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3628
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM udpglcur r
has only substance units: false
is: C00167
name: UDP-D-glucuronate
is: HMDB00935
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
constant: false
is: CHEBI:58052
initial concentration: 1.0

metaR CBASPte
name: Transport of N-carbamoyl-L-aspartate
type: Reaction
product: MODEL1310110020#
fast: false
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM 4nphsf c
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: 4-Nitrophenyl sulfate
is: CHEBI:35422
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: HMDB06492

metaM hestratriol c
name: 4,17 dihydroxy estradiol
boundary condition: false
constant: false
is: HMDB05896
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR SERPT
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.50
kinetic law: MODEL1310110020#
reversible: false
is described by: ECO:0000269
name: serine C-palmitoyltransferase

metaM HC01501 c
initial amount: NaN
name: hydroxidodioxidosulfidosulfate(1-)
has only substance units: false
type: Species
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:33539
boundary condition: false

metaM decdicrn e
has only substance units: false
initial concentration: 1.0
is: HMDB13325
notes: FORMULA: C17H29NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: decadienoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110020#_aa01c20e_0692_48df_8e8b_e4b6d54ddcb4
is: SBO:0000252
name: SLC26A6
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:65010
is: Q9Y3Y1
type: Species
boundary condition: true

metaM ksii core2 pre3 g
is: SBO:0000247
is: C00130
type: Species
notes: FORMULA: C47H76N4O33X CHARGE: -1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 3
is: CHEBI:58053
constant: false
is: HMDB00175
has only substance units: false

metaR OROTGLUt
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
fast: false
name: OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110020#_41524036_4ce7_401c_9658_913494ef5dfa
type: Species
constant: false
is encoded by: hsa:8781
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _8781_1_c
initial concentration: NaN
initial amount: NaN

metaM ksi deg37 l
constant: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 37
has only substance units: false
is: SBO:0000247
notes: FORMULA: C62H104N4O46 CHARGE: 0
type: Species
is: HMDB00812
initial amount: NaN
is: CHEBI:16953

metaM gacpail hs r
type: Species
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
is: CHEBI:61548
is: SBO:0000247
is: C00092
name: glucosaminyl-acylphosphatidylinositol
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_34b7a8c2_5b2e_4a02_8ac9_9677d0652c09
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: MBOAT2
is encoded by: hsa:129642
is: Q6ZWT7
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM xylt e
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:17151
name: xylitol
is: HMDB02917
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species

metaR RE3567C
fast: false
name: RE3567
reactant: MODEL1310110020#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaM Tn antigen l
has only substance units: false
boundary condition: false
type: Species
name: Tn antigen
initial concentration: 1.0
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
is: SBO:0000247
is: C04383
initial amount: NaN

metaM 3hexdcrn e
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C23H45NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
type: Species
constant: false
is: HMDB13336

metaM HC01401 x
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA

metaM k c
is: CHEBI:29103
type: Species
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
name: potassium
is: HMDB00586
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00238

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Transport of anthranilate
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_05dbe1a8_ade8_45df_9127_d1f65774789e
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:27068
initial concentration: NaN
name: PPA2
is: SBO:0000252
is: F8WDN9
boundary condition: true

metaR MI1PP
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 1-phosphatase
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR FAOXC2051843x
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000269

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
fast: false

metaR ACALDtm
name: acetaldehyde mitochondrial diffusion
reactant: MODEL1310110020#
type: Reaction
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000

metaR ACGBGBSIDEtl
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: acgbgbside hs intracellular transport
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false

metaR DASCBR
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110020#
name: dehydroascorbate reductase
modifier: MODEL1310110020#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.4.1
fast: false
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_ff5039e9_6fd1_49b9_8652_36a012cd00d0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: _AI348006_1_c
is encoded by: hsa:AI348006
has only substance units: false
initial amount: NaN

metaM CE5121 m
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: trans-3-decenoyl-CoA
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57449
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

metaM s2l2fn2m2masn e
notes: FORMULA: C90H145N6O65X CHARGE: -2
constant: false
initial concentration: 1.0
is: HMDB00244
name: PA6
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:3554
is: SBO:0000247
type: Species
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110020#_5d14c820_b8b6_445f_ac50_434de5f0a65c
initial concentration: NaN
boundary condition: true
has part: Q9NY65
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:1962
initial amount: NaN
constant: false
name: EHHADH:ACAA1:ACOX1

http://identifiers.org/biomodels.db/MODEL1310110020#_d2f2d3ba_3bd7_4695_8d07_0a6d61d1685c
is encoded by: hsa:39
initial concentration: NaN
is: Q9BWD1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ACAT2
constant: false
type: Species

metaM hestratriol e
type: Species
constant: false
name: 4,17 dihydroxy estradiol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial amount: NaN
initial concentration: 1.0
is: HMDB05896
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2986c3a1_c80e_420c_9f22_340733ad569d
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2639
has only substance units: false
is: SBO:0000252
name: GCDH
is: Q92947
constant: false
type: Species
boundary condition: true

metaR F1PGT
is version of: http://identifiers.org/ec-code/2.7.7.30
fast: false
is: SBO:0000176
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_988b964d_e549_493b_ac19_b7c33929a1cc
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:54187
initial amount: NaN
name: NANS
constant: false
is: SBO:0000252
is: Q9NR45
initial concentration: NaN

metaR S6TASE19ly
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
reversible: true
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR LEUKTRB4t
fast: false
product: MODEL1310110020#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_ae819942_6ce3_4ce3_9fd6_ae29c68e9dd9
type: Species
constant: false
initial amount: NaN
name: OGDH
boundary condition: true
is: B4E3E9
initial concentration: NaN
is encoded by: hsa:4967
has only substance units: false
is: SBO:0000252

metaM hdd2crn m
is: SBO:0000247
type: Species
name: trans-Hexadec-2-enoyl carnitine
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
is: HMDB06317

metaM crm hs c
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: CHEBI:52639
initial amount: NaN
name: N-acylsphingosine
type: Species
boundary condition: false

metaR XOLTRIOLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110020#
reversible: true
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110020#
name: lipid, flip-flop intracellular transport
type: Reaction

metaR THYOXt2
product: MODEL1310110020#
name: T4 transport via facilitated diffusion
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110020#
is: SBO:0000185

metaR FAOXC204C205x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaM mmcoa S m
initial concentration: 1.0
has only substance units: false
name: (S)-methylmalonyl-CoA(5-)
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: HMDB02310
constant: false
boundary condition: false
is: CHEBI:57327
is: SBO:0000247
initial amount: NaN

metaR 34HPPOR
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.27
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false

metaM cdp e
is: HMDB01546
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
type: Species
initial amount: NaN
name: CDP(3-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:58069
constant: false

metaM dgsn c
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
initial amount: NaN
boundary condition: false
constant: false
is: C00330
type: Species
is: CHEBI:17172
name: Deoxyguanosine
initial concentration: 1.0
is: SBO:0000247

metaR AG13T13g
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false

metaR r2140
type: Reaction
reversible: true
product: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM HC02023 r
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:46898
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Cholesterol-ester-ol
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1

metaR GUACYC
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
name: guanylate cyclase
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
fast: false
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.2
product: MODEL1310110020#

metaM pmtcoa r
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: CHEBI:3454
is: C00154
has only substance units: false
type: Species
is: HMDB01338
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false

metaM ksii core2 deg5 l
is: CHEBI:12936
type: Species
constant: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false

metaM appnn c
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:28261
initial concentration: 1.0
name: (+)-alpha-pinene
is: HMDB06525
constant: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1

metaR BHBtm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
product: MODEL1310110020#

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaM tethex3coa x
is: SBO:0000247
is: HMDB06243
initial amount: NaN
has only substance units: false
name: tetracosahexaenoyl coenzyme A
is: C16168
constant: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
type: Species
initial concentration: 1.0

metaM ksi pre17 g
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 17

metaR ARGtm
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110020#
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110020#
name: arginine mitochondrial transport via ornithine carrier
is: SBO:0000185

metaR r1716
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#

metaM gmp c
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: GMP
boundary condition: false
is: CHEBI:58115
has only substance units: false
is: HMDB01397
is: C00144

metaR AICART
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
reversible: true
reactant: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaR BALAtmr
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110020#
type: Reaction
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false

metaR NADPHtxu
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
kinetic law: MODEL1310110020#
is: SBO:0000185
name: NADPH transporter, peroxisome
reactant: MODEL1310110020#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction

metaR FAOXC181C161m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaM g3m8mpdol L r
is: SBO:0000247
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: HMDB01342
initial concentration: 1.0
is: C00459
is: CHEBI:37568

metaR r0480
fast: false
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176

metaM HC00460 c
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: CHEBI:58044
initial concentration: 1.0
name: 2,5-dihydroxybenzoate
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false

metaR TXASr
reversible: false
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000176
name: Thromboxane-A synthase
modifier: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/5.3.99.5
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ

metaM core2 g
has only substance units: false
boundary condition: false
is: CHEBI:15876
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: Core 2

metaR SAMHISTA
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.8
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
kinetic law: MODEL1310110020#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR BILGLCURtr
kinetic law: MODEL1310110020#
fast: false
name: glucuronidated compound transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110020#

metaM hpdcacrn c
name: heptadecanoyl carnitine
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06210
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3

metaR DM dgpi prot hs r
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaM 4hoxpacd c
type: Species
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: HMDB03767
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15621
boundary condition: false
is: SBO:0000247
name: (4-hydroxyphenyl)acetaldehyde
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d32fb738_1c89_4cbc_8118_2c4380ca77d8
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: _728637_1_c
constant: false
is encoded by: hsa:728637
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_5ae564c7_fd4b_43de_9cfe_c17c29b4df1c
is: P30837
name: ALDH1B1
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:219
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaM pmtcoa x
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01338
is: C00154
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0
is: CHEBI:57379
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false

metaM cdp c
has only substance units: false
is: CHEBI:58069
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00112
is: SBO:0000247
constant: false
name: CDP

metaM pa hs n
is: CHEBI:57739
constant: false
name: phosphatidate(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110020#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#

metaM pa hs m
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57739

http://identifiers.org/biomodels.db/MODEL1310110020#_19a1a7b7_344b_4a7c_ab57_202dfb7a5f06
name: GCK
constant: false
is encoded by: hsa:2645
has only substance units: false
is: P35557
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR NDPK9
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110020#
name: nucleoside-diphosphate kinase (ATP:IDP)

http://identifiers.org/biomodels.db/MODEL1310110020#_e10f98fc_8d5c_4bba_915f_76b5944824de
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: PIGW
is encoded by: hsa:284098
constant: false
is: Q7Z7B1

http://identifiers.org/biomodels.db/MODEL1310110020#_3e74381c_599a_4bee_bad6_48a2ec90202a
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1644
name: DDC
is: Q53Y41
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR B3GNT32g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000269
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110020#
reversible: false
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176

metaM gmp e
has only substance units: false
name: GMP(3-)
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01397
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_67a560d0_4994_42a4_975b_540cd366a089
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:80201
name: HKDC1
is: B3KT70
initial amount: NaN
has only substance units: false
type: Species

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_b1bd9c00_9907_48af_8f2e_f763fb407197
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:53354
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: PANK1

http://identifiers.org/biomodels.db/MODEL1310110020#_5cdedba5_2985_49cc_8773_f7d2618efe0f
has only substance units: false
is: P32321
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1635
initial concentration: NaN
type: Species
name: DCTD
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_35ffd165_570c_482b_ad4c_e7f360707857
is: SBO:0000252
name: _728226_1_m
type: Species
is encoded by: hsa:728226
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR H2O2t
product: MODEL1310110020#
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110020#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF

metaR ACGALtly
reversible: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110020#
name: N-acetyl-galactosamine lysosomal efflux
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110020#
fast: false

metaR RE0938E
reversible: true
name: RE0938
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.4.17.23
is described by: ECO:0000000
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11384769,PMID:11815627 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_2dd683ae_7a06_4a4d_af1e_7e471074c553
is: P17752
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: TPH1
boundary condition: true
is encoded by: hsa:7166
initial concentration: NaN

metaR r2331
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110020#

metaR NDPK8
modifier: MODEL1310110020#
name: Nucleoside-diphosphate kinase (ATP:dADP)
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
reversible: true
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_b6a3ef22_253e_4f52_bc15_7c850486f64c
type: Species
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:515
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_96edc4e2_f10c_4652_947e_436462621653
initial concentration: NaN
name: PLA2G10
initial amount: NaN
type: Species
is encoded by: hsa:8399
has only substance units: false
constant: false
is: O15496
boundary condition: true
is: SBO:0000252

metaR FUT99g
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.152
reversible: false
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
type: Reaction
name: Alpha-(1,3)-fucosyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false

metaM f1a l
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17151
initial amount: NaN
is: HMDB02917
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
constant: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM crm hs g
is: CHEBI:52639
name: N-acylsphingosine
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_8287cfb1_4933_4823_a525_0ebde74c9753
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6675
is: Q16222
has only substance units: false
constant: false
name: UAP1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a1e8079b_371a_462c_90d7_61c7955419e7
name: HPRT1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3251
is: P00492
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR KYNAKGAT
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_586d58dc_9414_4397_bf4c_f5ab1b5bdcd8
constant: false
is: P30837
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALDH1B1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:219
type: Species

metaR GLNS
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_173547ad_0f60_44e7_a984_37d023c47142
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: Q546H9
constant: false
name: ALDH5A1
initial amount: NaN
is encoded by: hsa:7915
boundary condition: true

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
type: Species
is: CHEBI:17899
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01993
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaR LEULEULAPc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR NDPK7
fast: false
reactant: MODEL1310110020#
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
type: Reaction
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269

metaR DMNONCOACRNCPT1
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
name: DMNONCOACRNCPT1
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_34d81044_9f0d_4ac3_b8e3_b95b66c0f36a
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:641372
name: ACOT6
has only substance units: false
is: Q3I5F7
constant: false

metaM hxcoa x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB00705
constant: false
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
boundary condition: false
is: SBO:0000247

metaR PHCDm
kinetic law: MODEL1310110020#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is: SBO:0000176
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR VALt5m
is described by: ECO:0000000
product: MODEL1310110020#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
name: Valine reversible mitochondrial transport

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM gmp g
type: Species
constant: false
has only substance units: false
name: GMP(3-)
boundary condition: false
initial amount: NaN
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
is: SBO:0000247
initial concentration: 1.0

metaR ACGBGBSIDEtg
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
product: MODEL1310110020#
fast: false
name: acgbgbside hs intracellular transport
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_a590f25b_6dfc_4f82_985e_11bcf1cacd01
has only substance units: false
is encoded by: hsa:29085
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9P019
name: PHPT1
boundary condition: true
initial concentration: NaN

metaM nm2masn g
has only substance units: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
is: SBO:0000247
is: C05884
constant: false
initial concentration: 1.0
notes: FORMULA: C42H70N3O30X CHARGE: 0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_509e5db9_b763_4277_bcfa_296be8f1a7f7
name: ADCY10
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55811
is: F5GWS5
initial concentration: NaN
has only substance units: false

metaM strch2 e
has only substance units: false
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial concentration: 1.0
boundary condition: false
is: CHEBI:4167
constant: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0
type: Species
initial amount: NaN
is: HMDB00122

metaR NDPK6
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
type: Reaction
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR C6DCc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM crm hs e
name: N-acylsphingosine
is: CHEBI:52639
initial amount: NaN
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR ASNtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: L-asparagine transport, mitochondrial
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction

metaR THRCYSNaEx
reversible: false
kinetic law: MODEL1310110020#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_8b6520e5_f9c2_40ba_b471_3923b167da53
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O15254
constant: false
is encoded by: hsa:8310
name: ACOX3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_234b7e8d_0b66_4ff4_9857_605c320b762a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:8818
name: DPM2
initial amount: NaN
constant: false
has only substance units: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_c81c6076_38f6_493e_8f9b_607529f1ca38
boundary condition: true
is encoded by: hsa:79611
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q9H6R3
name: ACSS3
initial concentration: NaN

metaR FERO
name: ferroxidase
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000134
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction

metaM fum m
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial concentration: 1.0
name: Fumarate
boundary condition: false
initial amount: NaN
is: C00122
is: HMDB00134
is: SBO:0000247
is: CHEBI:29806
constant: false
has only substance units: false
type: Species

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR VLCSr
is: SBO:0000176
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR CYTK6n
product: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
name: cytidylate kinase (CMP,CTP),nuclear
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_00883ddd_b368_4172_ab37_491baed59b7a
constant: false
is: SBO:0000252
is encoded by: hsa:1559
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: P11712
name: CYP2C9
boundary condition: true

metaR NDPK1
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110020#
is described by: ECO:0000134
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP)
modifier: MODEL1310110020#
is: SBO:0000176

metaR r0616
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110020#
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR ST8SIA12
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110020#
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#

metaR RE1709C
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709

metaR FACOAL244 1
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

metaR P5CRm
modifier: MODEL1310110020#
name: pyrroline-5-carboxylate reductase (m)
is: SBO:0000176
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
reactant: MODEL1310110020#

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110020#
name: Beta oxidation of fatty acid
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110020#_0bbcec81_7a6f_4559_ac97_11bfd5739c11
initial amount: NaN
type: Species
name: B3GNT8
constant: false
initial concentration: NaN
boundary condition: true
is: Q7Z7M8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:374907

metaM dhcholestanate c
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR PGLYCt
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
name: phosphatidylglycerol transport
fast: false

metaM hgentis c
is: CHEBI:16169
is: HMDB00130
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
name: homogentisate

http://identifiers.org/biomodels.db/MODEL1310110020#_1b0b1c94_9be1_4bef_9d0b_be2ffdb09021
is: SBO:0000252
name: ITPKB
constant: false
is encoded by: hsa:3707
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P27987
initial amount: NaN

metaR AMPDA
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
modifier: MODEL1310110020#
name: Adenosine monophosphate deaminase
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.6
kinetic law: MODEL1310110020#

metaM cholcoa c
name: choloyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57373
type: Species
is: HMDB01374
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_93379fc1_e052_4d9f_b2f6_149d9f63aa66
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ATP5E
constant: false
has only substance units: false
is encoded by: hsa:514

metaM gdpfuc c
is: CHEBI:57984
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
name: GDP-L-fucose(2-)
is: SBO:0000247
initial amount: NaN

metaR NDPK2
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_66c67170_18fc_4304_9fa2_6b06f2a69487
name: HEXA
is: P06865
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:3073
is: SBO:0000252
constant: false

metaM CE0233 c
constant: false
is: HMDB01993
type: Species
is: SBO:0000247
is: CHEBI:17899
name: 5beta-cholestane-3alpha,7alpha,27-triol
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0615
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.168
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR r2344
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
fast: false

metaR TALA
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
name: transaldolase
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.2.1.2

metaR 3SALAASPm
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
modifier: MODEL1310110020#
name: cysteinesulfinate-aspartate mitochondrial shuttle
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#

metaR C100CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR NDPK4
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
modifier: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dTDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR ST8SIA11
is version of: http://identifiers.org/ec-code/2.4.99.8
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR r1291
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110020#
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110020#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_adf35c7a_42c1_4e87_9394_a06664356eef
type: Species
is encoded by: hsa:5210
is: SBO:0000252
constant: false
name: PFKFB4
is: Q16877
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_8108e142_e204_4c44_9749_f5b13fcc55c7
has part: Q02221
is encoded by: hsa:125965
is encoded by: hsa:1329
is encoded by: hsa:1351
has part: P09669
is encoded by: hsa:9167
has part: Q53YB7
has part: Q53XN1
is encoded by: hsa:84701
has part: Q7Z4L0
has part: Q96KJ9
boundary condition: true
is encoded by: hsa:1345
initial concentration: NaN
is encoded by: hsa:1339
is encoded by: hsa:4514
has part: P13073
is encoded by: hsa:1327
has part: Q8TF08
is encoded by: hsa:1337
has part: P12074
is encoded by: hsa:1350
has part: P14854
has part: P00414
has part: Q7GXZ8
has part: P15954
has part: Q6FGA0
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:4512
is: SBO:0000297
is encoded by: hsa:4513
is encoded by: hsa:1349
has part: Q7GXY8
is encoded by: hsa:341947
has part: H0UI06
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1340
has part: P20674
has part: P24310
type: Species
is encoded by: hsa:1346
is encoded by: hsa:9377
is encoded by: hsa:1347
has part: P24311
has part: Q6YFQ2
is encoded by: hsa:170712

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR r0345
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
fast: false
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176

metaM dudp n
constant: false
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
name: dUDP(3-)
initial concentration: 1.0
is: CHEBI:60471
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR C3STDH1Pr
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
type: Reaction
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false

metaR ARSA
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
name: Arylsulfatase A
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.8
reversible: false
product: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#

metaR r2347
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_21cfc744_8a47_4e44_a98a_8d81d36aeee2
is: A0PJH2
initial amount: NaN
boundary condition: true
constant: false
name: ATP5H
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10476
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_4682bdf8_375c_461d_9782_7f03dc8d3564
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8879
is: O95470
name: SGPL1

metaR NDPK3
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_0158fbbf_8db8_442b_9e5f_3bfc19168772
boundary condition: true
is: Q16647
has only substance units: false
type: Species
name: PTGIS
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5740

metaR NDPK5
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
product: MODEL1310110020#
fast: false
type: Reaction
modifier: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_47ceb49d_963e_453a_a0d4_df127fd65558
constant: false
boundary condition: true
is: Q9NY28
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26290
is: SBO:0000252
name: GALNT8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_68097cff_62c9_41f2_9018_060fc57729f0
has only substance units: false
name: HADHB
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3032
is: P55084
initial concentration: NaN
constant: false

metaM argsuc c
is: C03406
is: HMDB00052
initial concentration: 1.0
name: N(omega)-(L-Arginino)succinate
notes: FORMULA: C10H17N4O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01113 EHMN_ABBREVIATION: C03406
initial amount: NaN
boundary condition: false
is: CHEBI:57472
constant: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_e6619f36_85af_4b67_b7ea_bc2d5acea5b3
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9H2X9
name: SLC12A5
initial concentration: NaN
constant: false
is encoded by: hsa:57468
has only substance units: false
boundary condition: true

metaM CE5160 r
boundary condition: false
is: CHEBI:57923
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: 3-oxo-cis-9-octadecenoyl-CoA
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160

metaR CDSm
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: false
name: phosphatidate cytidylyltransferase
type: Reaction
fast: false

metaR O2Stm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110020#
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reversible: true

metaM cs e deg3 l
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
is: HMDB00127
notes: FORMULA: C37H53NO44S4 CHARGE: -6

metaM CE5786 e
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: kinetensin
constant: false
boundary condition: false
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247

metaR DM ethamp r
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR r1292
reversible: true
fast: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_6b333520_88ac_45a7_9d66_8d74c5ccbbe7
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:U37519
name: _U37519_1_m

http://identifiers.org/biomodels.db/MODEL1310110020#_29054252_4585_4e83_801a_b590db8da1e9
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P05187
is encoded by: hsa:250
name: ALPP
constant: false

metaR CYSTA
fast: false
reactant: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is: SBO:0000176
type: Reaction
name: cysteine transaminase
is described by: ECO:0000304
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110020#

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0497
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110020#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
modifier: MODEL1310110020#
type: Reaction

metaM dlnlcgcrn m
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial amount: NaN
is: HMDB01311
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine

metaR r0617
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
fast: false
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: true

metaR r2346
reversible: true
product: MODEL1310110020#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false

metaR SIAT4Bg
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_543364ab_d6f2_4a1b_aca3_8985c12e426c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110020#_20e66a5f_b06c_48a8_8a98_0e43ff198479
initial concentration: NaN
is: Q96AT9
type: Species
is encoded by: hsa:6120
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: RPE
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4e21a6dd_2dfb_45b5_b29e_3e491f72755d
has only substance units: false
is: Q9NR34
type: Species
constant: false
name: MAN1C1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:57134
is: SBO:0000252

metaR GGH 7THFe
modifier: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110020#

metaM stcrn m
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
has only substance units: false
name: stearoylcarnitine
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00848
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_cd153661_d115_488c_a828_2ca6704adec2
initial amount: NaN
initial concentration: NaN
is: P14060
boundary condition: true
has only substance units: false
is encoded by: hsa:3283
is: SBO:0000252
type: Species
constant: false
name: HSD3B1

metaM q10h2 c
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaR RE2079R
name: RE2079
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_8180feb6_a574_4c4b_b594_69bdfb373197
initial amount: NaN
constant: false
type: Species
is: Q9H6R3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79611
name: ACSS3
has only substance units: false

metaM crtsl r
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00063
is: CHEBI:17650
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: cortisol

metaR FACOAL160i
type: Reaction
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
name: C160 fatty acid activation
is described by: ECO:0000269
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5c38178a_6a3b_4e0e_ba79_5c32d20ee4d1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10195
constant: false
type: Species
name: ALG3
is: SBO:0000252

metaR DITPtn
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: dITP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#

metaR TRPO2
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.11
product: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
modifier: MODEL1310110020#

metaM dtdp c
is: C00363
has only substance units: false
is: CHEBI:58369
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
name: dTDP
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_ddb693d1_5750_4ae2_961d_6ce90836144d
initial concentration: NaN
name: _2544_1_c
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2544
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r0915
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#

metaM dc2coa m
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:61406
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110020#_05c62b1a_ab9c_41f9_b76b_1c1b1e53034e
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PIGA
is encoded by: hsa:5277
is: B3KUV7
initial amount: NaN
type: Species

metaR ESTRADIOLtr
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
name: estradiol intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_e095ec0d_22c9_43ad_8fd5_4c43fd81a58c
initial concentration: NaN
has only substance units: false
boundary condition: true
name: KDSR
constant: false
type: Species
initial amount: NaN
is: Q06136
is encoded by: hsa:2531
is: SBO:0000252

metaR OCTDECCPT2
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM CE5868 e
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
boundary condition: false
is: SBO:0000247
is: HMDB02710
name: N-acetyl-seryl-aspartate
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:27485
initial amount: NaN

metaR FAOXC184C163m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM dudp m
name: dUDP(3-)
is: HMDB01000
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
initial amount: NaN
constant: false

metaM hs deg18 l
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial concentration: 1.0
is: HMDB01352
has only substance units: false
type: Species
is: SBO:0000247
name: heparan sulfate, degradation product 18
constant: false
is: CHEBI:17180
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2adc4f6a_c956_45b7_9500_994b0d390221
is encoded by: hsa:124
has only substance units: false
initial concentration: NaN
is: P07327
initial amount: NaN
constant: false
type: Species
name: ADH1A
is: SBO:0000252
boundary condition: true

metaR GLYBt4 2 r
reversible: true
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
name: Betaine transport (sodium symport) (2:1)
reactant: MODEL1310110020#

metaR r0494
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_30e5e7ba_f82a_4d08_b54d_d408e18514a9
name: TXNRD2
is encoded by: hsa:10587
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_ee8f2eda_940c_4594_b9ca_d7e4c4fe8b43
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5052
name: PRDX1
initial amount: NaN
has only substance units: false

metaM ksi pre21 g
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 21
boundary condition: false
has only substance units: false
is: C00130
type: Species
notes: FORMULA: C177H284N12O145S6X CHARGE: -7

metaR CYANtm
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_e6abd028_062f_4ae9_beab_ceeeec9cf923
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: DGKH
boundary condition: true
is: Q86XP1
initial amount: NaN
is encoded by: hsa:160851

metaR OCTDECCPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR VLCSp
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: false
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaM dtdp e
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: HMDB01274
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_34e09e47_a36f_4cf6_a5bd_5c9f44235421
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1545
has only substance units: false
constant: false
is: Q16678
initial concentration: NaN
initial amount: NaN
name: CYP1B1

metaR PEt
product: MODEL1310110020#
reactant: MODEL1310110020#
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_399c51fc_8820_475c_9c50_1c2842e223ba
is encoded by: hsa:1716
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: DGUOK
is: E5KSL6
boundary condition: true
constant: false
initial concentration: NaN

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r0917
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM m6masnB2 g
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
type: Species
boundary condition: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB00573
has only substance units: false
is: CHEBI:30825
is: SBO:0000247

metaM udpglcur c
initial concentration: 1.0
is: HMDB00935
boundary condition: false
has only substance units: false
is: CHEBI:58052
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
type: Species
constant: false
is: C00167
name: UDP-D-glucuronate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_9386b59b_e27b_4921_9857_2b3fa9536771
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PIP4K2B
type: Species
is: P78356
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8396

metaR EX ddecrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_ddf3c8ef_a7d7_4023_9239_ca6901d51ac9
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5831
type: Species
name: PYCR1
has only substance units: false
is: P32322

metaR EX c51crn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR FAOXC10C8x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM n2m2nmn l
is: HMDB00243
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: C00022
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15361
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_a7c38a90_c1bf_4c26_a5b9_c3d33415a34d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:285973
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q674R7
name: ATG9B

http://identifiers.org/biomodels.db/MODEL1310110020#_3e611ba9_e7e2_4be6_b002_f78e74680afc
boundary condition: true
type: Species
is encoded by: hsa:AF080579
initial amount: NaN
name: _AF080579_1_c
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

metaM docosahexcoa m
initial concentration: 1.0
initial amount: NaN
name: 3,7,10,13,16,19-docosahexenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaR B MANNASEly
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: beta-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.25
is: SBO:0000176
product: MODEL1310110020#

metaR AG13T12g
is: SBO:0000176
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000000
product: MODEL1310110020#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110020#
type: Reaction

metaR C181OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM nad c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57540
type: Species
is: C00003
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
constant: false
initial amount: NaN

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: L-argininium(1+)
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00517

metaR RE0690E
fast: false
product: MODEL1310110020#
name: RE0690
modifier: MODEL1310110020#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaM HC01223 m
has only substance units: false
is: CHEBI:57340
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_3f86e3f4_1383_446d_a791_443cccd43fdf
initial amount: NaN
initial concentration: NaN
name: SLC38A3
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10991
boundary condition: true
is: Q99624
type: Species

metaM HC01407 m
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
constant: false
boundary condition: false
type: Species
is: CHEBI:28276
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_ca01a77a_74a0_4dbc_80ce_26a866705fd0
is: O00400
is: SBO:0000252
type: Species
is encoded by: hsa:9197
has only substance units: false
name: SLC33A1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM galgalgalthcrm hs e
has only substance units: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:0
boundary condition: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
type: Species
constant: false
is: C00124
initial amount: NaN

metaM CE2917 e
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
boundary condition: false
is: C01936
type: Species
is: SBO:0000247
name: apelin-13
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR S6T18g
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17

metaM ficytC m
name: Ferricytochrome c
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: CHEBI:15991
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d99d6b49_9a40_4760_9cd6_3b1aa71c87a3
constant: false
is encoded by: hsa:10455
is: O75521
is: SBO:0000252
name: ECI2
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM pmtcoa c
has only substance units: false
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
initial amount: NaN
is: C00154
initial concentration: 1.0
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
is: HMDB01338
type: Species

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM HC02216 c
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:28922
initial concentration: 1.0

metaR S6T6g
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_fbf72527_a061_421b_aa87_30d25c7168f9
constant: false
initial concentration: NaN
initial amount: NaN
name: _AI285872_1_c
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI285872

metaR FACOAL191
reversible: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110020#_2832778e_a371_4181_bd07_cf9163128f24
has part: Q6IB54
has only substance units: false
is encoded by: hsa:522
initial concentration: NaN
type: Species
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is: SBO:0000297
boundary condition: true

metaM dlnlcgcrn c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
type: Species
is: HMDB01311
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16004
boundary condition: false
name: dihomo-gamma-linolenyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110020#_2515ebf6_de43_4e97_8684_8a6947d47cc1
is encoded by: hsa:5092
is: SBO:0000252
name: PCBD1
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110020#_1c0dc03e_fe7c_4f14_badc_76878c4054a7
is: SBO:0000252
is: P17568
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4713
type: Species
constant: false
name: NDUFB7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_70ad691c_3b0c_42ae_ad74_ab251c470a83
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: SDHA
initial concentration: NaN
is: SBO:0000252
is: P31040
is encoded by: hsa:6389
constant: false

metaR G6PDH2rer
reactant: MODEL1310110020#
reversible: true
type: Reaction
modifier: MODEL1310110020#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176

metaM xol27oh m
initial amount: NaN
is: SBO:0000247
is: HMDB02103
has only substance units: false
type: Species
initial concentration: 1.0
name: 26-hydroxycholesterol
boundary condition: false
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703

metaR r1177
type: Reaction
reversible: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
name: EC:3.1.1.13
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110020#

metaR THD1m
kinetic law: MODEL1310110020#
name: NAD(P) transhydrogenase
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.6.1.2
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#

metaR GAO2g
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
type: Reaction
name: Ganglioside O-acetylation
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110020#
is: SBO:0000176

metaR FUCASEe
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110020#
name: alpha-fucosidase, extracellular

metaM clpn hs c
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28494
constant: false
type: Species
name: cardiolipin
initial amount: NaN

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
has only substance units: false
is: C01342
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Ammonium
constant: false
is: HMDB00051
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_fb827382_f602_470a_932d_0b72a9ad4e80
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10599
is: Q9Y6L6
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: SLCO1B1

metaR NDPK9n
is: SBO:0000176
product: MODEL1310110020#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110020#
fast: false

metaR C6DCCACT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_90e95075_6cdd_4ad2_85f9_73fd3ab0d7d5
initial amount: NaN
name: SLC24A3
initial concentration: NaN
is: Q9HC58
boundary condition: true
is encoded by: hsa:57419
constant: false
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7b6788d8_dfee_4613_b84b_c3bd1bdf140c
boundary condition: true
is encoded by: hsa:39
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9BWD1
has only substance units: false
type: Species
name: ACAT2

metaM galgalgalthcrm hs g
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
type: Species
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial amount: NaN
is: CHEBI:26174

metaR GLNSERNaEx
is: SBO:0000185
fast: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_fccc65d3_ab06_47fa_bb66_b9509c48edd2
is: Q02318
initial concentration: NaN
is encoded by: hsa:1593
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: CYP27A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_e943feb5_dffe_40a5_a0e1_3cbd315fcf7e
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: F5H123
constant: false
type: Species
name: DYLX2
is encoded by: hsa:9856
is: SBO:0000252

metaM m7mpdol L r
is: CHEBI:37636
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
type: Species
is: SBO:0000247
has only substance units: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_8803fc3e_7fa0_4aa5_9ae3_9a63725a9b4c
is: Q969K7
constant: false
initial amount: NaN
is encoded by: hsa:113452
boundary condition: true
has only substance units: false
initial concentration: NaN
name: TMEM54
type: Species
is: SBO:0000252

metaR r0610
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
reversible: true
type: Reaction
fast: false
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000

metaM HC02216 e
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
is: SBO:0000247
type: Species
name: prostaglandin-f2beta
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM q10h2 e
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
name: Ubiquinol-10
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaM b2coa m
is: CHEBI:57332
boundary condition: false
initial amount: NaN
name: crotonoyl-CoA(4-)
is: HMDB02009
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaM hs deg24 l
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C31H50NO26 CHARGE: -1
is: CHEBI:15748
has only substance units: false
boundary condition: false
is: HMDB00127
initial concentration: 1.0
constant: false
name: GlcNAc-GlcA-(Gal)2-Xyl

http://identifiers.org/biomodels.db/MODEL1310110020#_822daa24_a9e7_4ccd_9ac5_1f3eb1d41bc6
boundary condition: true
name: _AI640625_1_c
has only substance units: false
is encoded by: hsa:AI640625
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR RE1709N
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
fast: false
name: RE1709
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM phyt c
is: CHEBI:37257
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
type: Species
boundary condition: false
constant: false
is: HMDB00801

http://identifiers.org/biomodels.db/MODEL1310110020#_3401c3f9_318c_4e93_9f57_29e25b8506e6
constant: false
initial amount: NaN
is encoded by: hsa:763
has only substance units: false
is: P35218
boundary condition: true
type: Species
name: CA5A
is: SBO:0000252
initial concentration: NaN

metaM thcrm hs g
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
name: trihexosyl ceramide
initial amount: NaN
constant: false

metaM HC01115 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: NeuNGc
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
constant: false
is: CHEBI:29025

metaR C141ACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaM hxcoa m
constant: false
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB06522
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110020#_48308cbf_70e6_4227_ae4a_6f772ec3e61e
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CA13
initial amount: NaN
is: Q8N1Q1
is encoded by: hsa:377677

metaR THRALANaEx
reversible: false
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1114df03_6b25_4425_8dc2_e8bdc24c5789
name: ENTPD2
type: Species
is: Q9Y5L3
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:954
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR 5THFtl
is: SBO:0000185
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: false
name: 5-glutamyl-THF transport, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
reactant: MODEL1310110020#
product: MODEL1310110020#

metaM abt e
is: HMDB01851
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: L-arabinitol
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false
is: CHEBI:18403

metaR PI5P3K
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.137
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
product: MODEL1310110020#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153

http://identifiers.org/biomodels.db/MODEL1310110020#_9eef4428_86eb_43d2_a35f_5903e16e6581
has part: P24539
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
has only substance units: false
has part: O75947
is encoded by: hsa:518
is encoded by: hsa:10476
initial concentration: NaN
is encoded by: hsa:515
type: Species
has part: P18859
is encoded by: hsa:522
boundary condition: true
initial amount: NaN

metaM arg L c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32682
name: L-argininium(1+)
type: Species
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
initial concentration: 1.0
is: HMDB00517

metaM q10h2 m
name: Ubiquinol-10
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaM phyt e
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false
is: CHEBI:37257
is: HMDB00801
name: phytanate
boundary condition: false
initial amount: NaN

metaR FAOXC10C8m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaM 4pyrdx c
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: CHEBI:30959
name: 4-pyridoxate
constant: false
is: HMDB00017
is: SBO:0000247

metaM gdpfuc g
initial amount: NaN
is: CHEBI:57984
is: HMDB01095
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
is: SBO:0000247
constant: false

metaR r0611
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1
product: MODEL1310110020#
fast: false
is described by: ECO:0000000
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:

metaM nm4masn g
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
has only substance units: false
type: Species
constant: false
is: C05882
initial amount: NaN
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_854f69b3_4fe6_493c_9a43_bceff282ebcd
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10331
initial concentration: NaN
name: B3GNT3
constant: false
is: Q9Y2A9
type: Species
initial amount: NaN

metaR OCD11COACPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_78353f49_f150_4fa0_afd5_d49ccbaed8ba
is: Q53XN1
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: COX8A
is encoded by: hsa:1351
initial concentration: NaN
constant: false

metaM orn e
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
name: Ornithine
initial concentration: 1.0
type: Species
is: CHEBI:0
initial amount: NaN
is: HMDB00214
boundary condition: false
is: C01602
has only substance units: false

metaR PHYHx
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.11.18
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: Phytanoyl-CoA dioxygenase, peroxisomal
product: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reversible: false

metaR RE1804C
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE1804
kinetic law: MODEL1310110020#

metaM ksi pre6 g
type: Species
has only substance units: false
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
is: C00130
is: SBO:0000247
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 6

metaR 5THFtm
name: 5-glutamyl-THF transport,m mitochondrial
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
kinetic law: MODEL1310110020#
fast: false
reversible: false
reactant: MODEL1310110020#

metaR PMTCOAtx
fast: false
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110020#
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_e81cbab6_9bac_4857_a538_d17828380e7c
is: Q9NQR4
is encoded by: hsa:56954
has only substance units: false
name: NIT2
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM abt c
boundary condition: false
type: Species
name: L-arabinitol
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:18403
is: HMDB01851

metaR LNLNCGt
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110020#

metaR r0614
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110020#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_fda0fa3b_6172_40f1_8285_99cfff7d9d7a
is encoded by: hsa:4514
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: P00414
boundary condition: true
name: COX3

http://identifiers.org/biomodels.db/MODEL1310110020#_e83c40ef_4d6e_4203_b81f_d7b328d6c35c
constant: false
is encoded by: hsa:29922
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NME7
boundary condition: true
is: Q9Y5B8

metaM dnad n
is: SBO:0000247
name: Deamino-NAD+
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 INCHI: InChI=1S/C21H26N6O15P2/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
boundary condition: false
type: Species
is: CHEBI:18304
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01179

metaR FAOXC16BRx
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR 3MOBte
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
fast: false

metaM HC01401 m
is: CHEBI:27668
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaR HSPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
reversible: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
name: heparan sulfate proteoglycan protease, lysosome (endosome)
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_39f52ef4_e7dd_48c3_9c51_6e39ec655a13
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI684467
has only substance units: false
name: _AI684467_1_m
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r2139
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185

metaM pd3 c
is: HMDB06500
name: Previtamin D3
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR NICRNTtn
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
reactant: MODEL1310110020#
name: NICRNT transport, nuclear trhough pore
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true

metaR 10FTHFtm
type: Reaction
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
is: SBO:0000185
product: MODEL1310110020#
fast: false

metaR r1179
name: EC:3.1.1.13
is described by: ECO:0000000
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction

metaM thym c
is: HMDB00262
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
constant: false
is: CHEBI:17821
initial amount: NaN
boundary condition: false
is: C00178
name: Thymine
initial concentration: 1.0

metaM orn c
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00214
is: C01602
name: Ornithine
is: CHEBI:0
constant: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaM arg L e
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: L-argininium(1+)
is: HMDB00517
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: CHEBI:32682
has only substance units: false
is: SBO:0000247

metaM 4pyrdx e
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 4-pyridoxate
is: SBO:0000247
is: CHEBI:30959
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: HMDB00017
type: Species
has only substance units: false

metaM mlthf c
initial amount: NaN
initial concentration: 1.0
constant: false
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533
is: C00143
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: CHEBI:15636
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_a1ba6b12_1010_44d0_b3ee_e62a12810507
is encoded by: hsa:8803
has only substance units: false
type: Species
name: SUCLA2
constant: false
is: E5KS60
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX tdcrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR r0340
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110020#_2f5f3f07_3d01_459f_91c0_c3f9a110fc51
has only substance units: false
is: Q7Z3X3
is encoded by: hsa:2799
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: GNS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_4d9a5454_aa69_4bb4_b0f6_279e9ebd65c9
is encoded by: hsa:AI378339
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AI378339_1_m

http://identifiers.org/biomodels.db/MODEL1310110020#_40ef0338_dd16_4225_9b1a_a6ec19e4e7bd
has only substance units: false
boundary condition: true
is encoded by: hsa:8034
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: P16260
type: Species
name: SLC25A16

metaR RE3001M
name: RE3001
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110020#

metaM glyc R c
is: HMDB00139
type: Species
constant: false
is: SBO:0000247
name: D-glycerate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
has only substance units: false
boundary condition: false

metaR DSAT
is described by: ECO:0000000
reversible: false
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110020#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#

metaM dudp c
name: dUDP
has only substance units: false
initial amount: NaN
is: CHEBI:60471
initial concentration: 1.0
is: SBO:0000247
is: HMDB01000
type: Species
is: C01346
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false

metaM 10fthf5glu e
constant: false
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](5)
has only substance units: false
boundary condition: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57454
is: SBO:0000247

metaM eicostetcrn c
constant: false
is: HMDB01356
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
type: Species
name: Eicosatetranoyl carnitine
has only substance units: false
is: CHEBI:57312

metaR THRSERNaEx
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000269
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110020#
type: Reaction
is: SBO:0000185

metaM ksi pre24 g
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 24
is: C00130
has only substance units: false
boundary condition: false
is: CHEBI:58053
is: HMDB00175

metaM hxcoa c
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB13130
has only substance units: false
type: Species
is: SBO:0000247
name: Hexanoyl-CoA (n-C6:0CoA)

metaR MTHFD2
modifier: MODEL1310110020#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
type: Reaction
kinetic law: MODEL1310110020#
name: methylenetetrahydrofolate dehydrogenase (NAD)
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR C12DCACOT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9808d255_7875_448d_b5f2_906f216e65be
initial concentration: NaN
name: AMY1C
is: P04745
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:278
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_069bedbb_4344_436e_8eb0_f584c2720463
constant: false
name: ACOT8
boundary condition: true
is: SBO:0000252
is: O14734
is encoded by: hsa:10005
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1029d5c2_b9cd_4d3f_9af2_080353dfa98d
is: SBO:0000297
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial amount: NaN
is encoded by: hsa:498
boundary condition: true
has part: B4DY56
constant: false
type: Species
has only substance units: false

metaM Lcystin e
name: L-cystine
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16283
has only substance units: false
is: HMDB00192
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false

metaM 5dhf m
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: pentaglutamyl folate (DHF)
initial amount: NaN
type: Species
is: HMDB06487
is: SBO:0000247
constant: false

metaM g3p c
type: Species
name: Glyceraldehyde 3-phosphate
is: CHEBI:58027
is: http://identifiers.org/pubchem.compound/3930
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: SBO:0000247
constant: false
is: HMDB01112
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00661

metaR PTRCOX1
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110020#
reversible: false
product: MODEL1310110020#
name: Putrescine:oxygen oxidoreductase (deaminating)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#

metaM 3snpyr m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: 3-Sulfinopyruvate
is: CHEBI:1665
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
has only substance units: false
is: HMDB02332

metaM glyphe c
is: http://identifiers.org/pubchem.compound/97415
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
name: Glycylphenylalanine
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR O2tm
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: O2 transport (diffusion)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
fast: false
reactant: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_9bef381b_f30c_4000_93e7_8ebdda676b09
has only substance units: false
name: _R33828_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:R33828

metaR UDPGLCAter
reversible: true
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_61ffcafc_9ef7_495a_85ff_d4a350006019
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152

metaR r2137
product: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110020#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_41e9f68d_c2f0_42fb_9400_bb907b31729a
constant: false
is: P11586
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4522
is: SBO:0000252
name: MTHFD1
type: Species
boundary condition: true

metaR NADtru
is: SBO:0000185
fast: false
reversible: false
name: NAD transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_4187a551_8cdc_435b_81c0_bbbd06af0345
boundary condition: true
has only substance units: false
name: HSD17B10
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q99714
initial amount: NaN
is encoded by: hsa:3028
constant: false

metaR C50CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR DOLPGT2 Ler
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.265
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_fb9d5c47_e806_4b7e_b616_c0bd43cf3969
boundary condition: true
is encoded by: hsa:3038
type: Species
name: HAS3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O00219
constant: false

metaM lnlncgcrn m
type: Species
initial amount: NaN
name: gamma-linolenyl carnitine
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110020#_f4638c14_0843_4b53_b6cf_31e9e2c724b3
name: HCST:PIK3CG
is: SBO:0000297
boundary condition: true
is encoded by: hsa:10870
type: Species
has part: Q9UBK5
has only substance units: false
has part: P48736
is encoded by: hsa:5294
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4289c5b2_7a7b_41ef_a46e_b502d986a8bb
type: Species
constant: false
is: A0S0A7
is encoded by: hsa:4846
boundary condition: true
has only substance units: false
name: NOS3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM 5dhf l
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
name: pentaglutamyl folate (DHF)
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06487
boundary condition: false
is: SBO:0000247

metaM nh4 n
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: ammonium
is: SBO:0000247
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
type: Species
is: CHEBI:28938

metaR F1Atg
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110020#
name: F1alpha transport (from golgi to lysosome)
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaR IDOURte
name: L-iduronate transport, extracellular
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000134
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaR EX doco13ac
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR O2tp
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: O2 transport, peroxisomal
reversible: true

metaM CE5236 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247
is: HMDB03952
constant: false
type: Species
is: CHEBI:28002

http://identifiers.org/biomodels.db/MODEL1310110020#_ff7b435c_bf58_475c_acd7_480c961a8692
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9Y259
boundary condition: true
is: SBO:0000252
name: CHKB
type: Species
constant: false
is encoded by: hsa:1120

metaM pail34p hs c
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57658
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM ivcrn e
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00688
boundary condition: false
name: isovaleryl carnitine
notes: FORMULA: C12H23NO4 CHARGE: 0

metaR RE2626M
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
fast: false
name: RE2626
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_07197eee_3177_4e40_93d3_08d7399ef299
is: P47895
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: ALDH1A3
boundary condition: true
is encoded by: hsa:220

metaM dc2coa x
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: trans-Dec-2-enoyl-CoA
is: HMDB01168
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM nad x
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: CHEBI:57540
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: C00003
type: Species
initial concentration: 1.0
is: HMDB00902
constant: false
boundary condition: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM glyphe e
name: Glycylphenylalanine
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/97415
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR DOLP Lter
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110020#
reversible: false
is described by: ECO:0000000
name: dolichol phosphate flippase (liver)
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#

metaR FAOXC9C7m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM nh4 m
is: HMDB00051
type: Species
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
has only substance units: false
initial concentration: 1.0
name: Ammonium
initial amount: NaN
boundary condition: false
is: C01342
is: SBO:0000247

metaR G14T8g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR FAOXC161802m
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110020#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
reactant: MODEL1310110020#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_830513a8_bb59_484b_be04_96e2dfecd1b6
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: SYNJ1
is: C9JFZ1
boundary condition: true
constant: false
is encoded by: hsa:8867

metaR ACCOAC
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM dhcholestanate r
is: HMDB00359
type: Species
constant: false
is: CHEBI:16577
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0

metaM 3hdcoa c
constant: false
is: HMDB00651
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial amount: NaN
type: Species
name: (S)-3-Hydroxydecanoyl-CoA
initial concentration: 1.0

metaM ivcrn c
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: isovaleryl carnitine
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
is: HMDB00688

metaR DOLASNT Ler
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.119
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110020#

metaM orn m
type: Species
is: CHEBI:46912
initial concentration: 1.0
is: SBO:0000247
is: C01602
initial amount: NaN
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
constant: false
is: HMDB00214
boundary condition: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_fb97b43a_8fcd_4a54_a06a_93c440bf4894
constant: false
is: SBO:0000252
is encoded by: hsa:92745
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC38A5
initial amount: NaN
is: Q8WUX1

http://identifiers.org/biomodels.db/MODEL1310110020#_48c0ffde_2f1c_45d5_a346_fca08d57bcd3
initial concentration: NaN
is encoded by: hsa:6390
name: SDHA:SDHB:SDHC:SDHD
type: Species
has part: P31040
is encoded by: hsa:6389
is: SBO:0000297
has part: Q99643
has part: P21912
initial amount: NaN
has part: O14521
is encoded by: hsa:6391
has only substance units: false
is encoded by: hsa:6392
constant: false
boundary condition: true

metaM pram c
name: 5-Phospho-beta-D-ribosylamine
is: SBO:0000247
is: HMDB01128
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
initial amount: NaN
boundary condition: false
is: C03090

metaR r0774
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110020#
reversible: true
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
fast: false

metaM subeac c
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
initial concentration: 1.0
boundary condition: false
name: suberic acid
has only substance units: false
is: HMDB00893

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_4ee9321a_17b2_4714_95bf_7814579572b3
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI761708
name: _AI761708_1_m
initial amount: NaN
initial concentration: NaN

metaR CHSTEROLtrc
kinetic law: MODEL1310110020#
name: transport of cholesterol into the cytosol
is described by: ECO:0000134
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
type: Reaction
fast: false
reactant: MODEL1310110020#
reversible: true

metaR FAOXC121C10x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM nicrnt n
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: nicotinate D-ribonucleotide(2-)
has only substance units: false
constant: false
is: CHEBI:57502
initial concentration: 1.0
is: HMDB01132
notes: FORMULA: C11H12NO9P CHARGE: -2 INCHI: InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p-2/t7-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

metaR r2132
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM udpgal e
is: CHEBI:58439
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00302
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cfd0ff5e_ebd0_423a_a41f_f676bc5729b7
constant: false
has only substance units: false
is encoded by: hsa:5538
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: PPT1
is: Q6FGQ4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a267eae6_4020_4c9e_b36a_2f81bd2d55af
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PLA2G4A
is: SBO:0000252
constant: false
is: P47712
has only substance units: false
type: Species
is encoded by: hsa:5321

metaM maltpt e
constant: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
name: maltopentaose
boundary condition: false
is: SBO:0000247
is: HMDB01296
type: Species
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
is: C02052
initial concentration: 1.0
initial amount: NaN

metaR DRPA
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
reversible: false
type: Reaction
kinetic law: MODEL1310110020#

metaR LNLNCACPT2
is: SBO:0000176
kinetic law: MODEL1310110020#
name: carnitine transferase
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR THMP
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: thiamin phosphatase
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD

metaR FBP26
is version of: http://identifiers.org/ec-code/3.1.3.11
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: false
type: Reaction
name: Fructose-2,6-bisphosphate 2-phosphatase
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.105
is: SBO:0000176

metaR UROLACer
is described by: ECO:0000000
type: Reaction
fast: false
name: uronolactonase, endoplasmic reticulum
is: SBO:0000176
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_8db11d62_082b_4923_ad6d_5a2e9927cc87
boundary condition: true
is: Q9HBH5
has only substance units: false
name: RDH14
type: Species
constant: false
is encoded by: hsa:57665
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_64093323_3462_4422_b9bc_6c7996c24b5c
is: SBO:0000252
name: _AI024818_1_c
is encoded by: hsa:AI024818
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR FADH2tx
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: FADH2 transporter, peroxisomal

metaM thbpt4acam c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
is: CHEBI:15374
type: Species
initial amount: NaN
is: HMDB02281

metaR r2133
modifier: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GLYCTO1p
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
name: Glycolate oxidase, peroxisome
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_dddfce4b_8e83_4742_8375_21f36f82be6e
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:3158
constant: false
name: HMGCS2
boundary condition: true
is: P54868
initial concentration: NaN

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
is described by: ECO:0000134
reversible: false
fast: false
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0202
kinetic law: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reversible: true
type: Reaction
fast: false
product: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_80851456_31a4_4994_9255_0636b1d1fe79
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q99808
name: SLC29A1
type: Species
is encoded by: hsa:2030

metaM Lcystin c
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16283
is: HMDB00192
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM Ser Thr g
is: CHEBI:58336
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: protein-linked serine or threonine residue (O-glycosylation site)
type: Species
is: HMDB00645
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
constant: false

metaR LNLNCACPT1
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
name: carnitine O-palmitoyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176

metaR GGH 10FTHF6GLUe
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110020#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaM gtp c
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01273
name: GTP
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_d7d81442_6a62_4b13_810b_b98a099c0783
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: O76062
has only substance units: false
name: TM7SF2
is encoded by: hsa:7108
boundary condition: true

metaM btcoa c
initial concentration: 1.0
is: CHEBI:57371
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
initial amount: NaN
name: Butanoyl-CoA
is: C00136
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaM 3octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 3,6,9,12,15-octadecapentenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_9ab5ce05_734a_4bb7_a5ef_054adeb97176
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PIGN
is: O95427
constant: false
is encoded by: hsa:23556
initial amount: NaN
type: Species
initial concentration: NaN

metaM dhcholestanate m
constant: false
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: HMDB00359
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_dd93d4ab_107c_40b4_b287_910fe8ca1918
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:79966
initial amount: NaN
has only substance units: false
constant: false
name: SCD5
is: Q86SK9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_f72bad54_407c_4e6e_b3f6_f2ee03c8d5ac
has only substance units: false
type: Species
is encoded by: hsa:3098
boundary condition: true
initial amount: NaN
is: P19367
initial concentration: NaN
constant: false
is: SBO:0000252
name: HK1

metaM udpgal g
name: UDP-D-galactose(2-)
has only substance units: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00302
type: Species
is: CHEBI:58439

metaM glutcoa m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: glutaryl-CoA(5-)
has only substance units: false
is: CHEBI:57378
is: HMDB01339
constant: false
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110020#
reversible: true
type: Reaction
modifier: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM galgalgalthcrm hs c
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
type: Species
is: HMDB00143
constant: false

metaR SERDGLNexR
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glutamine reversible exchange
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_089cdb27_c639_44ad_a344_8cbbc141005f
boundary condition: true
is: SBO:0000252
name: VNN1
type: Species
constant: false
is: O95497
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8876

metaM HC01842 c
constant: false
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
boundary condition: false
type: Species
is: CHEBI:31997
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Phosphodimethylethanolamine

metaM am6sa c
initial amount: NaN
is: CHEBI:57495
is: HMDB01280
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 2-aminomuconate 6-semialdehyde(1-)
type: Species
constant: false
notes: FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824
initial concentration: 1.0

metaR TYRCBOX
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
product: MODEL1310110020#

metaR TAUBETAtc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaM nad r
type: Species
boundary condition: false
is: HMDB00902
initial concentration: 1.0
constant: false
name: NAD(1-)
is: CHEBI:57540
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
has only substance units: false

metaR RE3566C
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110020#
name: RE3566
fast: false
is: SBO:0000176
product: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_7b46e893_e37e_4af7_b47f_dc69831b0b5f
type: Species
is: SBO:0000252
name: HSD17B4
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82
initial amount: NaN
constant: false

metaM ala L m
constant: false
is: CHEBI:16977
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
name: L-alanine
is: SBO:0000247
type: Species

metaM eicostetcrn m
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57312
is: SBO:0000247
name: Eicosatetranoyl carnitine
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
constant: false
is: HMDB01356
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3daae811_d672_45ca_9497_44b0b9964f9e
has only substance units: false
type: Species
is: P39656
boundary condition: true
is encoded by: hsa:1650
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: DDOST
constant: false

metaR HDCAter
fast: false
product: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110020#
is: SBO:0000185
name: palmitate ER export
is described by: ECO:0000000
type: Reaction

metaR r2131
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110020#

metaR RE2626C
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110020#
name: RE2626
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

metaR EX 4mtolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy tolbutamide exchange
type: Reaction

metaR UGCG
reversible: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.80
fast: false
kinetic law: MODEL1310110020#
name: Ceramide glucosyltransferase
is: SBO:0000176
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#

metaM tetpent3 e
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB06323
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM pser L c
boundary condition: false
name: O-Phospho-L-serine
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
has only substance units: false
is: HMDB01721
type: Species
is: CHEBI:15811
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaM glyc R m
constant: false
name: D-glycerate
initial concentration: 1.0
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00139
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_63a595a7_16fb_4553_91cc_c2dd965f1099
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6799
boundary condition: true
name: SULT1A2

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
type: Species
boundary condition: false

metaM Rtotal2 c
is: SBO:0000247
is: CHEBI:57876
initial concentration: 1.0
is: HMDB01564
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position

metaR KSII CORE2tly
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110020#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110020#

metaR ASNCYSNaEx
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000185
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110020#
is described by: ECO:0000269

metaR GK1
name: guanylate kinase (GMP:ATP)
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110020#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_20967c14_e7d4_4110_922d_583f8d909bbb
is: B3KQH0
name: SLC35C1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:55343
has only substance units: false
initial amount: NaN

metaR r0911
reversible: true
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
fast: false
is described by: ECO:0000000

metaR B3GNT33g
product: MODEL1310110020#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
reactant: MODEL1310110020#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR THRGLNNaEx
fast: false
kinetic law: MODEL1310110020#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaR ALAGLNexR
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
name: L-alanine/glutamine reversible exchange
fast: false

metaM tetpent3 c
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
is: HMDB06323
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0
has only substance units: false

metaM ksi pre18 g
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00130
name: keratan sulfate I biosynthesis, precursor 18
is: HMDB00175
is: CHEBI:58053
type: Species
initial concentration: 1.0
notes: FORMULA: C163H262N11O132S5X CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110020#_92ead0b5_f00a_4d28_83aa_2ba8ca9ae78a
type: Species
is: SBO:0000252
constant: false
name: PIGO
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:84720
is: Q8TEQ8
initial concentration: NaN

metaM dnad c
is: CHEBI:18304
is: C00857
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: Deamino-NAD+
boundary condition: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
initial concentration: 1.0

metaR GALU
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110020#
name: UTP-glucose-1-phosphate uridylyltransferase
reversible: true
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.7.9
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#

metaM coucoa m
has only substance units: false
type: Species
constant: false
name: 4-coumaroyl-CoA(4-)
is: CHEBI:57355
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00223
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1

metaR IDOURtly
name: iduronate transport into lysososme
is described by: ECO:0000269
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
modifier: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#

metaR AMACR2p
is described by: ECO:0000304
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/5.1.99.4
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
product: MODEL1310110020#
name: alpha-methylacyl-CoA racemase (reductase)
kinetic law: MODEL1310110020#
reversible: false

metaR URIK1
name: uridine kinase (ATP:Uridine)
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reactant: MODEL1310110020#

metaR EX CE4724 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin (1-12) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_70d05bc2_c2af_4a9c_84da_615ced830acc
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:55229
name: PANK4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9NVE7
constant: false

metaR BILIRED
is: SBO:0000176
name: Nad(p)h biliverdin reductase
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.24
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
reversible: false

metaM Ser Thr l
is: CHEBI:58190
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00224
has only substance units: false
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
boundary condition: false

metaM udpgal c
is: HMDB00302
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
name: UDP-D-galactose(2-)
is: SBO:0000247
constant: false
is: CHEBI:58439
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_22fedd21_6ef4_4163_8cfe_e380ebca69b9
boundary condition: true
has only substance units: false
name: _H77542_1_c
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H77542

metaM nh4 e
initial concentration: 1.0
name: ammonium
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
constant: false
is: HMDB00051
initial amount: NaN
boundary condition: false
is: CHEBI:28938
type: Species

metaM ak2lgchol hs e
is: C04317
initial amount: NaN
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
type: Species

metaR AG13T9g
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110020#

metaR 13DAMPPOX
reactant: MODEL1310110020#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110020#
type: Reaction
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000212
fast: false

metaM fum c
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
is: C00122
name: Fumarate
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00134

http://identifiers.org/biomodels.db/MODEL1310110020#_995567ae_1eea_486b_ad60_b5a07378a17b
boundary condition: true
has only substance units: false
is encoded by: hsa:3290
is: P28845
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: HSD11B1
constant: false

metaM Rtotal2 e
name: R total 2 position
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3554
boundary condition: false
has only substance units: false
type: Species
constant: false
is: C00255
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR r0913
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000185
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR M13N2Tg
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110020#
reversible: false
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.101
modifier: MODEL1310110020#

metaR LYStiDF
is described by: ECO:0000269
reversible: false
is: SBO:0000185
name: L-lysine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#

metaR ADK1m
is described by: ECO:0000269
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
name: adenylate kinase, mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_66d2c88f_cae6_4708_8bfd_b45ce3ba876a
initial amount: NaN
type: Species
is encoded by: hsa:1119
name: CHKA
is: SBO:0000252
has only substance units: false
is: P35790
initial concentration: NaN
boundary condition: true
constant: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR SPMS
name: spermidine synthase
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.16
modifier: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
fast: false

metaR MCCCrm
fast: false
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110020#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.4.1.4
product: MODEL1310110020#

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_3e86d30f_7e61_4cbb_b749_000e29966fb1
has only substance units: false
type: Species
constant: false
is: O15466
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29906
name: ST8SIA5

metaR NTP3e
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
reversible: false
type: Reaction
name: nucleoside-triphosphatase (GTP)

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_b41e13d2_81a4_4215_a154_4d636171a7e4
is: Q9UNU6
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: CYP8B1
initial concentration: NaN
is encoded by: hsa:1582

metaM xoltetrol m
is: CHEBI:17278
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
type: Species
is: HMDB01231
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2f3f0e88_a7ca_45af_93d4_8ffd83912dbd
initial amount: NaN
boundary condition: true
type: Species
name: NDUFS4
is encoded by: hsa:4724
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O43181

http://identifiers.org/biomodels.db/MODEL1310110020#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
type: Species
is: HMDB00304
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57847
constant: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false

metaM stcrn c
constant: false
type: Species
is: HMDB00848
has only substance units: false
name: stearoylcarnitine
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a5bf657b_1725_4fe2_9b97_151017d9a08c
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM tetdecdicoa m
is: HMDB02288
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
name: 5,8-tetradecadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110020#_e97c9e2a_e3fe_4a7e_92a8_837ddbaea43d
name: GLO1
boundary condition: true
initial concentration: NaN
is: Q04760
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2739
initial amount: NaN

metaM CE2417 m
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
is: CHEBI:28387
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
constant: false
has only substance units: false

metaM prgnlones c
name: pregnenolone sulfate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:35420
initial amount: NaN
is: HMDB00774
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764

metaM ksi deg6 l
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 6
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: HMDB00143

metaR P4502C94
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.48
name: cytochrome P450 2C9
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
is: SBO:0000176
modifier: MODEL1310110020#
reversible: false

metaM nad m
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: Nicotinamide adenine dinucleotide
has only substance units: false
constant: false
is: HMDB00902
is: CHEBI:57540
is: C00003
initial amount: NaN

metaM glutcoa c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: glutaryl-CoA(5-)
is: SBO:0000247
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
is: HMDB01339
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_8cf9062d_aefa_41c9_9ebb_09c9cabcd49c
boundary condition: true
initial amount: NaN
is encoded by: hsa:6818
constant: false
has only substance units: false
type: Species
name: SULT1A3
is: SBO:0000252
initial concentration: NaN

metaR RE1796M
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
name: RE1796
product: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_dfa3a51a_3b44_47c2_a92d_b84e60c0ef6c
initial concentration: NaN
constant: false
name: ALDOB
is: SBO:0000252
is encoded by: hsa:229
type: Species
is: P05062
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_f865068d_4d36_4375_91fa_9abd571276e0
name: PFAS
is: SBO:0000252
is encoded by: hsa:5198
constant: false
initial concentration: NaN
is: Q6P4B4
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR AGTim
is version of: http://identifiers.org/ec-code/2.6.1.44
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
kinetic law: MODEL1310110020#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000269
name: alanine-glyoxylate transaminase (irreversible), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110020#_6187b364_8c57_431e_a866_f44730dbf5a8
constant: false
name: _D87002_1_e
has only substance units: false
is encoded by: hsa:D87002
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_7eaaf87d_ceb8_49c0_913f_9deb7370a628
boundary condition: true
is: SBO:0000252
type: Species
name: PIP5K1B
constant: false
initial amount: NaN
is: O14986
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8395

http://identifiers.org/biomodels.db/MODEL1310110020#_ca8520fe_6db6_4e0b_bf5b_7166925dce2a
boundary condition: true
is encoded by: hsa:AI971023
has only substance units: false
name: _AI971023_1_c
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaM alpro m
type: Species
boundary condition: false
is: CHEBI:16882
constant: false
initial concentration: 1.0
name: S-Aminomethyldihydrolipoylprotein
is: SBO:0000247
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_dfdb85b4_4465_4e91_b5e8_947ba1ee58f5
type: Species
is encoded by: hsa:8604
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O75746
constant: false
name: SLC25A12

metaR r1853
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
reversible: false
name: Y+LAT2 Utilized transport

metaM dtmp m
constant: false
is: SBO:0000247
is: CHEBI:26999
is: C00364
type: Species
name: dTMP
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01227
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110020#_6233707b_90f7_4100_8983_29958b04be24
boundary condition: true
name: NDUFA3
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4696
is: O95167
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_24250727_c5dd_48a5_8a34_14e1f08f156c
constant: false
boundary condition: true
name: MTHFD1L
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B2RD24
is encoded by: hsa:25902

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_d8176c88_19b8_4460_afe3_aa54f22d3f89
type: Species
is: B1AN63
is encoded by: hsa:64802
name: NMNAT1
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR C181CRNt
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110020#
name: C181 transport into the mitochondria
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#

metaR NACHEXA21ly
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_1080d9af_a52f_45ea_90b7_797d5587a32a
boundary condition: true
is encoded by: hsa:7498
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: XDH
is: SBO:0000252
initial amount: NaN
is: P47989

metaM glyleu c
boundary condition: false
name: Glycylleucine
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
is: HMDB00759
is: http://identifiers.org/pubchem.compound/102468
is: C02155
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR r2341
kinetic law: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_2533356d_aa9a_466d_bea1_4b5fb9b62086
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: SLC6A10P
is encoded by: hsa:386757
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_52e1c213_ee86_4063_8364_069f19d461b5
is: D9HTE9
boundary condition: true
is encoded by: hsa:6576
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC25A1

http://identifiers.org/biomodels.db/MODEL1310110020#_8f6c514c_708e_47bb_819d_e7577ff210ab
is: P11310
initial amount: NaN
is: SBO:0000252
name: ACADM
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:34
constant: false

metaR GALT
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: galactose-1-phosphate uridylyltransferase

metaM HC01444 e
initial concentration: 1.0
constant: false
is: CHEBI:15754
is: SBO:0000247
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
name: Galactosylglycerol
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_85885907_e175_4713_89ee_2988b26c1180
has only substance units: false
name: CTSA
initial amount: NaN
type: Species
is: P10619
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:5476
boundary condition: true

metaR TETTET6COAtx
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
fast: false
reversible: true

metaR PROt4
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110020#
name: Na+/Proline-L symporter
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
type: Reaction
reversible: false

metaM lnlncgcrn c
name: gamma-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
is: HMDB06318
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR ADCim
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is: SBO:0000176
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5efa8b8a_576b_44c3_98f6_217a2ef5b348
initial amount: NaN
is: Q9Y619
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: SLC25A15
is encoded by: hsa:10166
boundary condition: true

metaR CYTK7n
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110020#
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP,UTP),nuclear
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110020#

metaR G14T11g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_55f599d0_d6c0_47cf_a858_9c8f25539bc7
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10317
constant: false
type: Species
name: B3GALT5
initial amount: NaN
has only substance units: false

metaR P4502C93
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.48
name: cytochrome P450 2C9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) SUBSYSTEM: Limonene and pinene degradation EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:11950794,PMID:11996015 NOTES:assumed to take place on outer membrane NJ
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
reversible: false
is: SBO:0000176
type: Reaction

metaM ksii core2 pre2 g
is: HMDB00175
is: CHEBI:58053
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 2
initial concentration: 1.0
is: C00130
has only substance units: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_449cb937_137e_4b59_8db9_597b854a69e8
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PLCB1
is encoded by: hsa:23236

metaR TETDEC2CRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaM HC01118 r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
type: Species
name: presqualene diphosphate(3-)
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_ff914f31_d9ba_4f24_af3a_d5317724853c
type: Species
is encoded by: hsa:219
initial amount: NaN
boundary condition: true
constant: false
name: ALDH1B1
is: P30837
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2343
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR TCYNTt
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185

metaM glyleu e
type: Species
is: http://identifiers.org/pubchem.compound/102468
has only substance units: false
is: SBO:0000247
name: Glycylleucine
notes: FORMULA: C8H16N2O3 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB00759
initial amount: NaN
boundary condition: false
is: C02155

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR PHYTt
type: Reaction
product: MODEL1310110020#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaR HDCAtr
reversible: true
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is: SBO:0000185

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
kinetic law: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reversible: true
is described by: ECO:0000304
product: MODEL1310110020#
is: SBO:0000185
type: Reaction

metaM hmgcoa c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
type: Species
is: HMDB01375
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110020#_12206b29_733f_4f60_be2f_8d3cc112ac00
is encoded by: hsa:1376
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CPT2
type: Species
boundary condition: true
has only substance units: false
constant: false
is: P23786

metaM succ e
type: Species
name: succinate(2-)
is: CHEBI:30031
initial amount: NaN
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_5f8c4ed5_ec42_4d3b_a6cc_2ac2120cfa6c
boundary condition: true
constant: false
is: P24539
name: ATP5F1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:515
is: SBO:0000252
type: Species

metaM 3hmp m
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00023
constant: false
name: 3-hydroxy-2-methylpropanoate
type: Species
initial concentration: 1.0
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
has only substance units: false

metaR G14T13g
type: Reaction
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000

metaR CYTK8n
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110020#
reversible: true
product: MODEL1310110020#
fast: false
type: Reaction
modifier: MODEL1310110020#

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
reversible: true
name: isoleucine transaminase, mitochondrial

metaM ppi m
is: SBO:0000247
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
boundary condition: false
initial amount: NaN
constant: false
name: Diphosphate
type: Species
is: C00013
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_b5bc32a6_9083_49b8_ad86_cd2d37c467f8
initial concentration: NaN
boundary condition: true
name: _R14373_1_x
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:R14373

metaM pe hs r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16038
name: phosphatidylethanolamine
type: Species
boundary condition: false
constant: false

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_3d24f91a_3552_4bd7_9afe_9a546060e412
type: Species
constant: false
name: CTH
is: P32929
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1491
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ppi n
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: diphosphate(3-)
boundary condition: false
is: CHEBI:33019
is: SBO:0000247
initial amount: NaN
is: HMDB00250
constant: false

metaR ACACT1r
type: Reaction
modifier: MODEL1310110020#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
product: MODEL1310110020#
name: acetyl-CoA C-acetyltransferase
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110020#

metaM c5dc e
name: glutaryl carnitine
notes: FORMULA: C12H21NO6 CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB13130
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaM amet c
is: HMDB01185
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: S-Adenosyl-L-methionine
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: C00019
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaM ksii core4 pre6 g
boundary condition: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 6
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110020#_b64a34f0_ab27_4ab0_bf1d_d3a79394c861
is encoded by: hsa:4200
is: P23368
boundary condition: true
has only substance units: false
name: ME2
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_61754f18_f069_4157_94bd_a7b35171722f
type: Species
constant: false
is encoded by: hsa:1103
has only substance units: false
is: Q6LEN6
name: CHAT
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_7ec2857c_3989_4470_aa0f_925c15ff22d0
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5096
initial concentration: NaN
type: Species
name: PCCB
is: P05166
constant: false
is: SBO:0000252

metaR AG13T15g
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR SUCCt4 2
fast: false
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
name: succinate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110020#_b8980a7b_9551_47f8_9a5b_015fcccf8ef6
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: ACHE
is: SBO:0000252
is encoded by: hsa:43

metaR FAOXC227C226m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM 1glyc hs e
name: 1 acyl phosphoglycerol
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
is: HMDB00972
is: CHEBI:57454
constant: false

metaR C16OHc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_fc7b7e5e_6431_4018_ad13_0e99d17d87dd
is encoded by: hsa:AA419122
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: _AA419122_1_c
boundary condition: true
type: Species
initial concentration: NaN

metaM succ c
type: Species
is: CHEBI:30031
initial amount: NaN
is: HMDB00254
name: Succinate
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042

metaM pmtcrn r
is: HMDB00222
constant: false
name: L-palmitoylcarnitine
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17490
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR DPPS
is: SBO:0000176
kinetic law: MODEL1310110020#
reversible: false
name: decaprenyl synthase
fast: false
product: MODEL1310110020#
is described by: ECO:0000134
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
type: Reaction

metaM 2mb2coa c
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
is: HMDB02054
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
constant: false
initial amount: NaN

metaM sprm e
type: Species
boundary condition: false
is: HMDB01256
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: CHEBI:45725
initial concentration: 1.0
constant: false
name: spermine(4+)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_6df5682a_7253_41a6_adc7_f9ea372511a4
initial amount: NaN
is encoded by: hsa:5091
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: PC

metaR r0531
type: Reaction
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34

metaM thcholstoic c
boundary condition: false
has only substance units: false
is: CHEBI:18402
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB03873

metaM galgalthcrm hs g
name: Gal-Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:26174
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_2e0ddddc_f2f4_435b_9980_66a5393bc574
name: ATP5I
is encoded by: hsa:521
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P56385
type: Species
constant: false

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
product: MODEL1310110020#
reactant: MODEL1310110020#

metaR r0309
reactant: MODEL1310110020#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaM ksii core4 pre9 g
is: CHEBI:28067
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
type: Species
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
initial amount: NaN

metaM ksi deg11 l
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
has only substance units: false
name: keratan sulfate I, degradation product 11
is: HMDB00143
is: CHEBI:12936
type: Species
initial amount: NaN

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Utilized transport
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185

metaR r1013
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
type: Reaction
reversible: false
name: Transport reaction

metaR ACt2m
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110020#

metaR NAt5
name: sodium/ammonium proton antiporter
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
type: Reaction
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269

metaR BACCLm
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110020#_7d26b4b3_adfc_4544_a2d6_e06857f589af
initial amount: NaN
is encoded by: hsa:AA532636
is: SBO:0000252
has only substance units: false
constant: false
name: _AA532636_1_m
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_00a6491c_8fec_4b96_a9c9_eebcd370be48
name: MTHFS
is: P49914
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10588
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_44355d2d_43e5_4179_97c1_91efa3c66507
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALDH3A2
type: Species
constant: false
initial amount: NaN
is: P51648
initial concentration: NaN
is encoded by: hsa:224

metaM vacccoa m
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: vaccenyl coenzyme A
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/9543677
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06521

metaR r0308
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110020#_52771b04_40f4_44c6_a2a4_0fba53f318ca
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1595
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: CYP51A1
is: Q16850

metaM cbp m
notes: FORMULA: CH2NO5P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00164 EHMN_ABBREVIATION: C00169
is: C00169
is: HMDB01096
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:58228
initial concentration: 1.0
name: Carbamoyl phosphate

http://identifiers.org/biomodels.db/MODEL1310110020#_7de55a45_1fca_47cb_b0e6_1062b9716ecc
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: P09417
is encoded by: hsa:5860
type: Species
name: QDPR
is: SBO:0000252

metaR r2526
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110020#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction

metaR RE1517M
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110020#
is: SBO:0000176
name: RE1517
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110020#

metaR r1014
fast: false
product: MODEL1310110020#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction
name: Postulated transport reaction
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c549c48f_c29d_4cbc_9feb_f9c1a2657016
constant: false
initial amount: NaN
has only substance units: false
name: _T83654_1_c
type: Species
is encoded by: hsa:T83654
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM dd3coa x
type: Species
name: 3-dodecenoylcoa
has only substance units: false
constant: false
is: HMDB04257
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0

metaM pail hs n
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c3f4aa50_7759_4045_a720_83d87d251211
is encoded by: hsa:5145
type: Species
is encoded by: hsa:5158
is: SBO:0000297
constant: false
name: PDE6A:PDE6H:PDE6B
has part: Q13956
boundary condition: true
is encoded by: hsa:5149
has part: P16499
initial amount: NaN
has part: B7Z9T9
initial concentration: NaN
has only substance units: false

metaM 3htdcoa m
constant: false
initial concentration: 1.0
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: HMDB02288

metaM ksi deg15 l
name: keratan sulfate I, degradation product 15
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00143
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: CHEBI:12936
constant: false

metaR MMTSADm
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
product: MODEL1310110020#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false

metaM ocdececrn m
constant: false
is: HMDB06351
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 11-octadecenoyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0

metaM xylu D c
constant: false
has only substance units: false
is: CHEBI:17140
is: SBO:0000247
is: HMDB01644
name: D-xylulose
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reversible: true
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR r1019
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR HKYNH
product: MODEL1310110020#
name: 3-Hydroxy-L-kynurenine hydrolase
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.3
is described by: ECO:0000269
modifier: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_acf3eecd_2d7f_4e2c_9fac_b878e150f531
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q9NRZ5
name: AGPAT4
is encoded by: hsa:56895
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_57acf204_e5ef_47ca_b295_12391ebfb07d
initial concentration: NaN
has only substance units: false
boundary condition: true
name: HPGDS
initial amount: NaN
is encoded by: hsa:27306
is: SBO:0000252
type: Species
is: O60760
constant: false

metaM 4abut c
type: Species
is: C00334
boundary condition: false
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:3628
initial concentration: 1.0
name: 4-Aminobutanoate
constant: false
has only substance units: false
initial amount: NaN

metaM galgbside hs g
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
name: galactosylgloboside
has only substance units: false
is: CHEBI:18259
boundary condition: false
initial concentration: 1.0

metaM lneldccrn m
type: Species
is: SBO:0000247
name: Linoelaidyl carnitine
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06461
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
boundary condition: false
has only substance units: false

metaM acrn x
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57589
type: Species
is: HMDB00201
name: O-acetylcarnitine
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

metaM cmusa c
name: cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate
is: CHEBI:994
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C7H6NO5 CHARGE: -1 INCHI: InChI=1S/C7H7NO5/c8-5(7(12)13)4(6(10)11)2-1-3-9/h1-3H,8H2,(H,10,11)(H,12,13)/p-2/b2-1-,5-4- HEPATONET_1.0_ABBREVIATION: HC01288 EHMN_ABBREVIATION: C04409
is: SBO:0000247
is: C04409

http://identifiers.org/biomodels.db/MODEL1310110020#_9dfd2a39_e50e_43cc_a1d5_56dd4da07214
initial concentration: NaN
is: P14550
has only substance units: false
name: AKR1A1
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:10327
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_f9423293_3f5b_43d1_bb36_896a05f7a535
initial concentration: NaN
constant: false
has only substance units: false
is: B4DX62
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM ppi r
type: Species
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00013
name: Diphosphate
is: HMDB00250
is: SBO:0000247
constant: false

metaM thyox L c
boundary condition: false
is: CHEBI:18332
constant: false
initial concentration: 1.0
name: L-thyroxine
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ddece1crn c
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: dodecenoyl carnitine
type: Species
constant: false
notes: FORMULA: C19H35NO4 CHARGE: 0
is: HMDB03712
boundary condition: false

metaM gm3 hs g
is: SBO:0000247
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
is: CHEBI:60065

metaM 3decdicoa m
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 3,7-decadienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_02baa201_eb16_4e50_ba79_c6c2997ca4cf
type: Species
boundary condition: true
has only substance units: false
is: P51648
is: SBO:0000252
name: ALDH3A2
is encoded by: hsa:224
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_c0f67163_e235_4d98_9431_b34a301dd27b
type: Species
is: SBO:0000252
name: ALDH2
initial amount: NaN
constant: false
is encoded by: hsa:217
boundary condition: true
is: P05091
initial concentration: NaN
has only substance units: false

metaM malcoa r
is: SBO:0000247
initial concentration: 1.0
is: HMDB01175
boundary condition: false
constant: false
name: malonyl-CoA(4-)
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384

http://identifiers.org/biomodels.db/MODEL1310110020#_65999441_b588_45da_91e3_f2abddfd8353
boundary condition: true
constant: false
is encoded by: hsa:5298
is: Q9UBF8
is: SBO:0000252
has only substance units: false
type: Species
name: PI4KB
initial concentration: NaN
initial amount: NaN

metaR UGALNACtg
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: UDP-GalNAc Golgi transport via CMP antiport
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false

metaR NAHCO3 HCLt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
name: bicarbonate transport (HCl/NaHCO3 exchange)
product: MODEL1310110020#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_571720cf_ea52_402c_a5ab_1af0e69b5a35
boundary condition: true
constant: false
is: O00142
initial concentration: NaN
name: TK2
is: SBO:0000252
is encoded by: hsa:7084
initial amount: NaN
type: Species
has only substance units: false

metaR C160CPT2
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110020#
name: C160 transport into the mitochondria
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reactant: MODEL1310110020#
reversible: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR CGMPt
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000269
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (10257.1) or (10057.2) or (10057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11447229,PMID:12637526,PMID:12835412,PMID:14507663,PMID:15631998 NOTES:IT
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
type: Reaction
name: cGMP transport (ATP-dependent)

http://identifiers.org/biomodels.db/MODEL1310110020#_179f2871_1fac_4e57_85e6_181456abeabc
initial amount: NaN
is: SBO:0000252
is: P08294
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6649
constant: false
name: SOD3
type: Species

metaM g1m8mpdol L r
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
is: C05870
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaR RE1342C
kinetic law: MODEL1310110020#
fast: false
name: RE1342
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_dd7f8b17_086b_4b75_8921_1a5f48ac4ae1
is encoded by: hsa:1891
is: Q13011
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ECH1
initial concentration: NaN
boundary condition: true
constant: false

metaM gly m
is: HMDB00123
name: Glycine
is: C00037
type: Species
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:15428
is: SBO:0000247
has only substance units: false

metaM HC00695 m
type: Species
initial amount: NaN
name: S-Succinyldihydrolipoamide
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
constant: false
is: CHEBI:17432
boundary condition: false
is: SBO:0000247

metaM thmpp m
constant: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:45931
has only substance units: false
is: HMDB01372
type: Species
boundary condition: false
name: Thiamine diphosphate

metaR C142CPT1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR PROt2r
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110020#
name: L-proline reversible transport via proton symport
product: MODEL1310110020#
reversible: true

metaM glu5p m
is: HMDB01228
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
name: L-Glutamate 5-phosphate
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58274
boundary condition: false
is: SBO:0000247
type: Species

metaM 3tetd7ecoa m
constant: false
is: HMDB05066
is: SBO:0000247
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

metaM 5thf e
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: HMDB06487
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: pentaglutamyl folate (THF)
initial concentration: 1.0
boundary condition: false

metaM thyox L e
is: SBO:0000247
is: HMDB00248
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
is: CHEBI:18332
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: L-thyroxine

metaM cs e deg1 l
type: Species
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57737
has only substance units: false
is: HMDB00868
constant: false
initial concentration: 1.0

metaR PROSTGH2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269

metaR NRPPHRtu
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110020#
name: Norepinephrine uniport
reversible: true
fast: false
modifier: MODEL1310110020#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_35e6139a_d80f_4141_9612_ae14baf79891
type: Species
is: SBO:0000252
initial concentration: NaN
name: NPR2
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4882
has only substance units: false

metaR C160CPT1
kinetic law: MODEL1310110020#
name: production of Palmitoylcarnitine
reversible: false
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000269

metaR PNTEH
is version of: http://identifiers.org/ec-code/3.5.1.92
name: Hydrolase Class ( RXN R02973)
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
product: MODEL1310110020#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
is described by: ECO:0000269
fast: false

metaM CE5162 r
is: CHEBI:57923
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: trans,cis-2,9-octadecadienoyl-CoA

metaM c5dc c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB13130
is: SBO:0000247
notes: FORMULA: C12H21NO6 CHARGE: 0
type: Species
constant: false
name: glutaryl carnitine

metaM hs deg25 l
type: Species
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1018
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c156e3b0_b07b_47be_acb7_747670949c9e
is encoded by: hsa:5167
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
name: ENPP1
initial concentration: NaN
initial amount: NaN
is: P22413

metaR NDPK10
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaM so3 m
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00240
is: CHEBI:17137
constant: false
initial amount: NaN
initial concentration: 1.0
name: hydrogensulfite
has only substance units: false

metaM HC00342 c
initial amount: NaN
name: cis-aconitate(3-)
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
is: CHEBI:16383
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_bb9cf971_0727_40af_8630_0dd5da956f03
has only substance units: false
is encoded by: hsa:8854
type: Species
is: O94788
name: ALDH1A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM succ m
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: C00042
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:30031
is: HMDB00254
name: Succinate

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR r1433
reversible: false
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_67154c9d_f315_4dba_a936_02aa583fb211
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:52
constant: false
has only substance units: false
is: Q59EH3
type: Species
boundary condition: true
name: ACP1
is: SBO:0000252

metaM tdcoa c
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57385
is: HMDB01521
is: SBO:0000247
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_60c3cfac_ccf4_44e2_8704_99b6dc4ac530
boundary condition: true
constant: false
is encoded by: hsa:2990
initial concentration: NaN
has only substance units: false
is: P08236
initial amount: NaN
type: Species
is: SBO:0000252
name: GUSB

metaR HEDCECRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaM gly x
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
has only substance units: false
is: HMDB00123
constant: false
is: SBO:0000247
boundary condition: false

metaR EX 35cgmp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3',5'-Cyclic GMP exchange
type: Reaction

metaR SUBERCROT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR r2521
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Utilized transport
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_67d12ae3_6c48_4486_b957_5eb554731566
has only substance units: false
is: O00462
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4126
is: SBO:0000252
name: MANBA
initial amount: NaN
constant: false
type: Species

metaR r2393
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110020#

metaR 2HBt2
reactant: MODEL1310110020#
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
name: 2-hydroxybutyrate cotransport with proton
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_230a91c6_e89a_4670_9595_40e759abc076
is: SBO:0000252
is: P49189
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:223
type: Species
has only substance units: false
name: ALDH9A1
initial amount: NaN

metaR BILDGLCURtr
reversible: true
name: glucuronidated compound transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaM pmtcrn x
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17490
name: L-palmitoylcarnitine

metaM xoldiolone r
has only substance units: false
is: CHEBI:28477
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_f02b67d9_b149_464b_8331_89a90c7c80e7
name: SLC27A1
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:376497

http://identifiers.org/biomodels.db/MODEL1310110020#_2488d089_fe1c_4233_a863_93902aca7b34
initial amount: NaN
name: SLC27A1
is encoded by: hsa:376497
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: Q6PCB7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_1136efa9_6e3b_42a0_85fa_335ced3f6070
is encoded by: hsa:259230
boundary condition: true
has only substance units: false
name: SGMS1
initial amount: NaN
initial concentration: NaN
type: Species
is: D3DWC4
is: SBO:0000252
constant: false

metaM dlnlcg e
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
is: CHEBI:53486
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0

metaR r2520
type: Reaction
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000185

metaM perillyl e
notes: FORMULA: C10H16O CHARGE: 0 INCHI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3 EHMN_ABBREVIATION: C02452
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB03634
initial amount: NaN
name: perillyl alcohol
is: CHEBI:15420
has only substance units: false

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110020#
type: Reaction
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
is described by: ECO:0000000

metaM 5thf c
name: pentaglutamyl folate (THF)
initial amount: NaN
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00440
constant: false
is: CHEBI:3729
has only substance units: false
is: HMDB01396
type: Species

metaR SERCYSNaEx
product: MODEL1310110020#
reversible: false
fast: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110020#_f4d896a4_46a3_45d1_95c1_fb4e17443132
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P23677
type: Species
initial concentration: NaN
name: ITPKA
constant: false
is encoded by: hsa:3706
has only substance units: false

metaR RE2349C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110020#
product: MODEL1310110020#
name: RE2349
type: Reaction
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000

metaR r1435
reactant: MODEL1310110020#
name: Transport reaction
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110020#
reversible: false

metaM succoa x
is: SBO:0000247
type: Species
constant: false
name: Succinyl-CoA
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
is: HMDB01022
boundary condition: false
has only substance units: false

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
name: 2,4-decadienoylcoa
constant: false
boundary condition: false
is: HMDB01168

metaR B3GNT312g
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_305c5877_18f9_48ed_adbc_eadb1a98926d
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: PLCXD2
is: Q0VAA5
is encoded by: hsa:257068
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_b655378a_db33_4132_81f1_a3515a129d5b
initial concentration: NaN
name: AMD1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:262
is: SBO:0000252
is: P17707

metaM tchola e
is: HMDB00036
is: SBO:0000247
name: taurocholic acid
initial concentration: 1.0
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC225C226m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2a17bf75_c00a_4d5a_bc8c_fd8bafb39e7f
boundary condition: true
is encoded by: hsa:506
type: Species
is encoded by: hsa:498
is encoded by: hsa:513
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial amount: NaN
has part: A8K092
has only substance units: false
initial concentration: NaN
has part: P36542
is: SBO:0000297
has part: P30049
has part: P06576
has part: P56381
is encoded by: hsa:509
is encoded by: hsa:514

metaR FPGS4m
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.17
type: Reaction
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
name: folylpolyglutamate synthetase (DHF), mitochondrial
product: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_380dbed9_420d_45fc_b9f6_90519e47bd00
is: SBO:0000252
constant: false
is encoded by: hsa:50
initial concentration: NaN
type: Species
initial amount: NaN
is: Q99798
name: ACO2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c452b322_f1b1_4f15_af89_698ada0b3eff
is: P78428
has only substance units: false
is encoded by: hsa:7054
constant: false
name: TH
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR r0960
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

metaR NTD8
modifier: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
name: 5'-nucleotidase (dGMP)
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM dlnlcg c
boundary condition: false
constant: false
initial amount: NaN
name: dihomo-gamma-linolenic acid (n-6)
type: Species
is: CHEBI:53486
is: HMDB02925
is: SBO:0000247
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
has only substance units: false

metaR S6TASE2ly
reactant: MODEL1310110020#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false
product: MODEL1310110020#

metaR ACOAD1fm
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
reversible: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110020#
fast: false
is: SBO:0000176
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM 2mpdhl m
initial amount: NaN
name: S-(2-Methylpropanoyl)-dihydrolipoamide
boundary condition: false
type: Species
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
constant: false
is: CHEBI:17577
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_1f7b09f9_0bae_474e_863d_a9e43556273e
constant: false
initial concentration: NaN
has only substance units: false
name: GLUD1
is: SBO:0000252
type: Species
is: E9KL48
initial amount: NaN
boundary condition: true
is encoded by: hsa:2746

metaM ddece1crn e
name: dodecenoyl carnitine
has only substance units: false
is: HMDB02250
notes: FORMULA: C19H35NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR TRDR2
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
name: Thioredoxin (ubiquinone 10) reductase (NADPH)
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (7296.1) or (7296.4) or (7296.2) or (7296.3) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES:Xia et al, 2003, JBC, 2141-2146

metaR IVCRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_da21b047_00f0_4760_9b1f_b1db3d93ed2d
is encoded by: hsa:4831
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: NME2
initial concentration: NaN
initial amount: NaN
is: P22392
boundary condition: true

metaM pail hs c
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN

metaR PERILLYLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
kinetic law: MODEL1310110020#
name: xenobiotic transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
type: Reaction
reversible: true

metaR PTDCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110020#_ab18a789_29bb_4804_baa9_5fe207faafc1
constant: false
is: SBO:0000252
is encoded by: hsa:AI697028
boundary condition: true
has only substance units: false
name: _AI697028_1_m
initial amount: NaN
type: Species
initial concentration: NaN

metaM lneldccrn c
name: Linoelaidyl carnitine
constant: false
type: Species
boundary condition: false
is: HMDB06461
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial amount: NaN

metaM triodthy c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00265
initial amount: NaN
is: CHEBI:18258
type: Species

metaM ppi x
name: Diphosphate
is: CHEBI:33019
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
type: Species
is: C00013
is: HMDB00250
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_a83cd193_9bf2_4fb4_bd6b_f27432fa3337
constant: false
is encoded by: hsa:5832
name: ALDH18A1
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P54886
boundary condition: true

metaR r1581
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000

metaR MG3er
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
fast: false
is described by: ECO:0000000
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
is: SBO:0000176

metaM 4abut e
is: C00334
name: 4-Aminobutanoate
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628

metaM tchola c
is: HMDB00036
initial concentration: 1.0
is: SBO:0000247
name: taurocholic acid
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species

metaM r5p r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial amount: NaN
boundary condition: false
name: alpha-D-Ribose 5-phosphate
constant: false
is: HMDB00618
has only substance units: false
is: CHEBI:18189
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR GDPtg
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
name: GDP intracellular transport

metaR DDCRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR NTD5
fast: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
is described by: ECO:0000134
reversible: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dTMP)
is: SBO:0000176

metaR MTHFDm
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110020#
reactant: MODEL1310110020#

metaR r0642
reversible: true
reactant: MODEL1310110020#
is: SBO:0000176
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_7e8d9d3f_391f_4f9d_9e80_8e7f9bd738ec
constant: false
initial amount: NaN
is: P31350
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: RRM2
is: SBO:0000252
is encoded by: hsa:6241

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaM ade c
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Adenine
is: CHEBI:16708
initial concentration: 1.0
is: HMDB00034

http://identifiers.org/biomodels.db/MODEL1310110020#_06c0fac8_58f2_46d0_99ef_0ab69ae0d69e
is: Q13946
initial concentration: NaN
name: PDE7A
is: SBO:0000252
is encoded by: hsa:5150
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM 7dhf c
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: HMDB06559
initial concentration: 1.0
type: Species
constant: false
name: heptaglutamyl folate (DHF)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_4f8fade3_283e_4922_9a1f_738620280cc9
type: Species
boundary condition: true
is encoded by: hsa:3162
name: HMOX1
has only substance units: false
is: SBO:0000252
is: Q6FH11
initial concentration: NaN
initial amount: NaN
constant: false

metaM ipdp c
has only substance units: false
initial concentration: 1.0
is: CHEBI:128769
initial amount: NaN
is: HMDB01347
is: SBO:0000247
boundary condition: false
is: C00129
type: Species
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: Isopentenyl diphosphate

http://identifiers.org/biomodels.db/MODEL1310110020#_0a09620a_c675_4a07_9ad2_3d34246c5aa9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9H1K4
boundary condition: true
name: SLC25A18
type: Species
is encoded by: hsa:83733
has only substance units: false

metaR S6T14g
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#

metaM 2mb2coa m
has only substance units: false
boundary condition: false
is: HMDB02054
is: SBO:0000247
is: CHEBI:57337
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
name: 2-methylcrotonoyl-CoA(4-)
type: Species

metaR CYOOm3
product: MODEL1310110020#
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/1.9.3.1
name: cytochrome c oxidase, mitochondrial Complex IV
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
modifier: MODEL1310110020#
reactant: MODEL1310110020#

metaR ACt2r
is: SBO:0000185
is described by: ECO:0000000
name: acetate reversible transport via proton symport
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
reactant: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5ee52648_ff29_44a2_beba_9db2d583bc81
boundary condition: true
is: E7EPA7
is encoded by: hsa:7086
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: TKT

metaR r0641
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110020#
reversible: true
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110020#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
fast: false
type: Reaction
reactant: MODEL1310110020#

metaR NNATn
type: Reaction
name: nicotinate-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:12574164 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
fast: false

metaR OCDCAtr
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110020#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
fast: false

metaM ade e
is: HMDB00034
name: adenine
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16708

metaM octe5coa m
constant: false
name: 5-octenoylcoa
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0

metaR GLNLASEer
is described by: ECO:0000000
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: true
name: gluconolactonase, endoplasmic reticulum
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_e62cd678_3301_44b2_a463_e037f710e653
initial amount: NaN
boundary condition: true
is encoded by: hsa:51727
name: CMPK1
initial concentration: NaN
constant: false
type: Species
is: B2R6S5
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_434cbd4b_29f0_4352_a113_7424314c1aed
has only substance units: false
is encoded by: hsa:85365
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: ALG2
initial concentration: NaN
is: SBO:0000252

metaR NTD3
reactant: MODEL1310110020#
name: 5'-nucleotidase (dCMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110020#
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110020#

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.40
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaR URATEt
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110020#
name: urate export from cytosol
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cc09b2ec_9525_4de1_85dd_9c3279488219
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6553
is: Q9NSW9
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: SLC9A5

metaM 7dhf e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06559
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
initial concentration: 1.0
initial amount: NaN
name: heptaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110020#_95d95e8c_1144_47be_981f_527601574fc0
name: SLC27A5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10998
is: Q9Y2P5
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR PPDOy
kinetic law: MODEL1310110020#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110020#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR r0750
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
reactant: MODEL1310110020#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

http://identifiers.org/biomodels.db/MODEL1310110020#_9ba15f4f_8404_4e26_9128_29023f558c88
is: A5JJ20
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8671
initial amount: NaN
name: SLC4A4

metaR ABTD
reactant: MODEL1310110020#
fast: false
type: Reaction
kinetic law: MODEL1310110020#
name: L-arabinitol 4-dehydrogenase
is: SBO:0000176
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
reversible: true

metaM hx2coa m
is: SBO:0000247
constant: false
is: HMDB06870
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: trans-Hex-2-enoyl-CoA
is: C05998

metaM amet m
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
is: C00019
is: CHEBI:15414
boundary condition: false
name: S-Adenosyl-L-methionine
is: HMDB01185

http://identifiers.org/biomodels.db/MODEL1310110020#_28f07cd7_9a74_4cba_b603_63109ab969d7
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q16762
boundary condition: true
name: TST
initial concentration: NaN
is encoded by: hsa:7263
is: SBO:0000252

metaR PPDOx
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
fast: false
product: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_1265ac47_7282_4aa4_b00d_cd5904a17a9d
name: HAL
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:3034
has only substance units: false
boundary condition: true
is: B4E0V8

metaR CDIPTr
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.11
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: phosphatidylinositol synthase (Homo sapiens)
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_b9504c18_e2fa_454e_875c_c8ebd8dfd190
is encoded by: hsa:7084
initial concentration: NaN
constant: false
is: O00142
boundary condition: true
name: TK2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_7f199447_5d26_4091_9cf1_aacf02c92b37
type: Species
initial concentration: NaN
initial amount: NaN
name: CPT1B
is: B7Z5T8
is encoded by: hsa:1375
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR FAOXC225C226x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaM succoa m
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01022
is: CHEBI:57292
name: Succinyl-CoA

metaR ACACt2
type: Reaction
name: acetoacetate transport via proton symport
is: SBO:0000185
product: MODEL1310110020#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
fast: false

metaM ksi deg32 l
initial amount: NaN
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
type: Species
is: HMDB00143
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 32

metaR r0633
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.7.3
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110020#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110020#

metaR 7DHFtl
name: 7-glutamyl-DHF transport, lysosomal
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR SEBACACT
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR r1587
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110020#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

metaM dec24dicoa x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
name: 2,4-decadienoylcoa
initial amount: NaN
is: HMDB01168
is: SBO:0000247
type: Species
constant: false

metaR RE1573M
kinetic law: MODEL1310110020#
is: SBO:0000176
type: Reaction
reversible: true
name: RE1573
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC00342 m
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: cis-aconitate(3-)
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
is: CHEBI:16383
constant: false

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaM 4abut n
initial concentration: 1.0
name: 4-Aminobutanoate
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
is: C00334
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM thr L e
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: L-threonine
is: HMDB00167
type: Species
initial concentration: 1.0
is: CHEBI:16857

metaR EX 3octdeccrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_2aa9c43b_1e46_4053_bf65_ae14829f6374
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1892
has only substance units: false
initial amount: NaN
is: P30084
name: ECHS1
initial concentration: NaN
boundary condition: true

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR RE3244R
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
reversible: true
name: RE3244
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176

metaR 7DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
name: 7-glutamyl-DHF transport,m mitochondrial
type: Reaction

metaR LNELDCCPT2
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#

metaR r0634
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
kinetic law: MODEL1310110020#
reversible: true
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110020#

metaR r1586
product: MODEL1310110020#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR G14T9g
reactant: MODEL1310110020#
product: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
kinetic law: MODEL1310110020#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is described by: ECO:0000000

metaR NTD1
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
name: 5'-nucleotidase (dUMP)
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110020#
fast: false
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaR DUTPDPn
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.23
reactant: MODEL1310110020#
name: dUTP diphosphatase, nuclear
modifier: MODEL1310110020#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false

metaM lpro m
name: Lipoylprotein
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
initial concentration: 1.0
is: CHEBI:15804
initial amount: NaN
boundary condition: false

metaR r1168
reversible: false
product: MODEL1310110020#
fast: false
name: EC:2.3.1.26
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110020#

metaR BTND1
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is: SBO:0000176
name: biotinidase (biotin)
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110020#

metaR r0741
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
reversible: true
fast: false
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
modifier: MODEL1310110020#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15

metaR FACOAL2252
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase

metaR r1429
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Free diffusion
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#

metaM CE5867 e
initial concentration: 1.0
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
is: CHEBI:27485
is: SBO:0000247
constant: false
has only substance units: false
name: N-acetyl-seryl-aspartyl-lysyl-proline
boundary condition: false
initial amount: NaN
is: HMDB02710
type: Species

metaR S6TASE14ly
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110020#

metaM 4abut m
initial amount: NaN
constant: false
is: HMDB00112
is: C00334
is: SBO:0000247
boundary condition: false
is: CHEBI:16865
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
initial concentration: 1.0
has only substance units: false
type: Species

metaR PCRNtm
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reversible: false
name: transport into the mitochondria from cytosol (carnitine)
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
fast: false

metaR GLUTCOADHm
is: SBO:0000176
modifier: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
name: glutaryl-CoA dehydrogenase (mitochondria)
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000304
kinetic law: MODEL1310110020#
reversible: false

metaM leuktrC4 c
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN
name: leukotriene C4(2-)
is: SBO:0000247
type: Species
is: CHEBI:57973
is: HMDB01198

metaR FACOAL2251
reversible: true
product: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
reactant: MODEL1310110020#

metaR r1589
product: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaM dhbpt c
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
is: CHEBI:20680
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: 6,7-dihydrobiopterin
is: HMDB00038
is: SBO:0000247

metaR TAUPAT1c
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaR r1167
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
name: EC:2.3.1.26
type: Reaction
reactant: MODEL1310110020#
reversible: false
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR HEX7
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110020#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110020#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
name: hexokinase (D-fructose:ATP)
reactant: MODEL1310110020#
reversible: false

metaM thexddcoa m
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
name: trans7,10-hexadecadienoylcoa
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02288
is: SBO:0000247
boundary condition: false

metaM dcamp c
is: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species
is: CHEBI:57567
is: HMDB00536
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0
has only substance units: false

metaM 3thexddcoacrn c
boundary condition: false
notes: FORMULA: C23H41NO5 CHARGE: 0
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02014
has only substance units: false

metaM acrn m
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
name: O-acetylcarnitine
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_67dd29b4_cb76_4808_b7b9_822038430512
initial amount: NaN
constant: false
boundary condition: true
name: AK4
type: Species
is encoded by: hsa:205
is: P27144
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_f4a6e851_e521_4381_8d87_9c01535bafa2
is encoded by: hsa:9962
constant: false
is: Q9UGH3
name: SLC23A2
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_9893c14f_661d_44ab_9ca9_4abe2fd48ded
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: O75387
constant: false
is: SBO:0000252
name: SLC43A1
is encoded by: hsa:8501
has only substance units: false

metaR r1588
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_952c2d97_4088_4c2c_8ea1_38f0683a931f
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AU149534
is: SBO:0000252
type: Species
name: _AU149534_1_e
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_3ce198a7_240b_41f4_b94f_913af56cd1b6
is: Q01959
name: SLC6A3
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6531

metaR CREATt4 2 r
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
reversible: true
name: Creatine transport (sodium symport) (2:1)
kinetic law: MODEL1310110020#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction

metaM ksi deg29 l
has only substance units: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 29
is: HMDB00143
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C96H157N6O80S3 CHARGE: -3

metaR r0743
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110020#
is described by: ECO:0000000
reversible: false
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
reactant: MODEL1310110020#
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_ee40f5d1_d9e7_42e4_bde0_61b5b9b3c68f
has only substance units: false
type: Species
is: Q08ET0
boundary condition: true
is encoded by: hsa:515
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: ATP5F1

metaR r1583
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110020#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

metaM leuktrC4 e
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: leukotriene C4(2-)
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
is: CHEBI:57973
is: HMDB01198

http://identifiers.org/biomodels.db/MODEL1310110020#_8cd058e1_dbc1_4ca3_8c4d_32922a30447d
boundary condition: true
type: Species
constant: false
name: PLA2G7
has only substance units: false
initial concentration: NaN
is: Q13093
is encoded by: hsa:7941
initial amount: NaN
is: SBO:0000252

metaM ksi pre11 g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
type: Species
is: CHEBI:28067
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
initial amount: NaN

metaM 7dhf l
initial concentration: 1.0
is: HMDB06559
has only substance units: false
boundary condition: false
name: heptaglutamyl folate (DHF)
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110020#_050b0268_cb16_40b7_a091_74b2ee7dfce8
boundary condition: true
is encoded by: hsa:10905
is: SBO:0000252
initial concentration: NaN
type: Species
is: O60476
name: MAN1A2
initial amount: NaN
constant: false
has only substance units: false

metaR r0744
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
product: MODEL1310110020#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_c16c506e_f563_4361_a40e_171c69f5d9ac
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AA278423_1_c
is encoded by: hsa:AA278423
type: Species
has only substance units: false
constant: false

metaM dgdp c
initial concentration: 1.0
initial amount: NaN
name: dGDP
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
is: C00361
constant: false
is: CHEBI:58595
is: SBO:0000247
boundary condition: false
is: HMDB00960

metaR AMANK
is version of: http://identifiers.org/ec-code/5.1.3.14
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.59
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
name: N-acetyl-D-mannosamine kinase

metaR RDH3a
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110020#
name: retinol dehydrogenase (11-cis,NADPH)
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
fast: false
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_8db16166_1f71_41aa_9b97_d2d2c6f6054f
boundary condition: true
constant: false
is encoded by: hsa:10678
type: Species
name: B3GNT2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR CORE2GTg
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
type: Reaction
modifier: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.102
is described by: ECO:0000000
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110020#
fast: false

metaR ARABR
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is: SBO:0000176
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
fast: false
name: arabinose reductase

metaR r0423
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110020#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM ppcoa c
is: CHEBI:57392
is: C00100
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
type: Species
is: HMDB01275
name: Propanoyl-CoA

metaR ACOAD10m
product: MODEL1310110020#
fast: false
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
kinetic law: MODEL1310110020#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110020#

metaM malcoa c
boundary condition: false
is: C00083
is: CHEBI:57384
is: SBO:0000247
initial amount: NaN
is: HMDB01175
constant: false
initial concentration: 1.0
type: Species
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false

metaM pglyc hs e
type: Species
boundary condition: false
has only substance units: false
name: phosphatidylglycerol(1-)
is: CHEBI:60523
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_1a6b8e4e_3a78_4fcd_9962_bf69960c65b0
type: Species
has only substance units: false
is: B3KT19
initial concentration: NaN
name: PIK3R1
constant: false
initial amount: NaN
is encoded by: hsa:5295
boundary condition: true
is: SBO:0000252

metaM c12dccoa x
is: HMDB03712
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
type: Species
boundary condition: false
initial concentration: 1.0
name: dodecanedioylcoa
has only substance units: false

metaM ocde9ecoa x
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
boundary condition: false
name: 9-octadecenoylcoa

metaR FAOXC102C103m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_d74a661e_df2b_4932_b095_807441247bc2
is: Q9P0Z9
is encoded by: hsa:51268
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: PIPOX
boundary condition: true

metaR CYSTGLUex
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110020#
name: L-cystine/L-glutamate exchanger

metaR S2L2N2M2MASNtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: s2l2n2m2masn transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110020#
is described by: ECO:0000000
reactant: MODEL1310110020#
product: MODEL1310110020#
reversible: false

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR FORMCOAtx
name: formyl coa transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110020#

metaR TMDK1m
name: thymidine kinase (ATP:thymidine)
reactant: MODEL1310110020#
reversible: false
product: MODEL1310110020#
is: SBO:0000176
modifier: MODEL1310110020#
is described by: ECO:0000269
kinetic law: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction

metaR r0638
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.1.2
type: Reaction
reversible: true
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110020#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110020#

metaR EX c5dc
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR FBA2
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000304
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110020#

metaR r0424
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110020#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true

metaR RE1530C
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#

metaR DOLGPP Ler
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
reactant: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
product: MODEL1310110020#
reactant: MODEL1310110020#
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304

metaM xoldiolone c
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
is: HMDB02197
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:28477
has only substance units: false

metaR FACOAL2042
modifier: MODEL1310110020#
reactant: MODEL1310110020#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_4aad0e81_ef1c_46c5_b6ff_6dc8ef312b77
is encoded by: hsa:205
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: AK4
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR 4HPRO LTte
kinetic law: MODEL1310110020#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110020#
name: Transport of trans-4-hydroxy-L-proline
reactant: MODEL1310110020#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110020#_75df6031_28ba_45ac_979e_ce4f842c2fa3
name: SLC29A2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q14542
is encoded by: hsa:3177

metaM hmgcoa m
initial amount: NaN
type: Species
is: HMDB01375
boundary condition: false
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
constant: false
initial concentration: 1.0

metaM stcoa m
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
is: CHEBI:57394
initial amount: NaN
is: C00412

metaR LNELDCCPT1
name: carnitine O-palmitoyltransferase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#

metaR r1585
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaR BETALDHxm
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
fast: false
name: betaine-aldehyde dehydrogenase, mitochondrial
reactant: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_dac47cce_2c8d_4154_a898_3645c6c8060d
has part: Q6I9V2
has part: P25705
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:498
is encoded by: hsa:509
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
is: SBO:0000297
boundary condition: true
type: Species
has only substance units: false

metaR r1584
kinetic law: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaM 10fthf m
name: 10-formyltetrahydrofolate(2-)
type: Species
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00972
boundary condition: false
is: CHEBI:57454
initial amount: NaN

metaM pglyc hs c
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: phosphatidylglycerol(1-)
is: CHEBI:60523
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM 7dhf m
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial concentration: 1.0
is: HMDB06559
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: heptaglutamyl folate (DHF)
has only substance units: false

metaR SQLEr
fast: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
name: Squalene epoxidase, endoplasmic reticular (NADP)
type: Reaction
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.14.13.132
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000176
reversible: false
is described by: ECO:0000134

metaM thr L c
constant: false
name: L-threonine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
is: HMDB00167
is: SBO:0000247

metaM cs a deg5 l
is: CHEBI:15936
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
notes: FORMULA: C23H36O24S CHARGE: -2
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0747
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
modifier: MODEL1310110020#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is: SBO:0000176

metaM ppi c
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
is: HMDB00250
name: Diphosphate
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:0

metaR r0068
reactant: MODEL1310110020#
fast: false
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.1
product: MODEL1310110020#

metaR HEX1
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
type: Reaction
is: SBO:0000176
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110020#

metaR ASCBt4
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110020#
name: L-ascorbate transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
modifier: MODEL1310110020#

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaM retinol cis 11 c
is: CHEBI:16302
is: HMDB06216
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 11-cis-retinol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_cc6f4795_a889_465c_9288_8cf9ca68b6dd
is: SBO:0000252
is: O43868
constant: false
type: Species
name: SLC28A2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9153
initial amount: NaN
boundary condition: true

MODEL1310110020
species: metaM 10fthf7glu e
reaction: metaR PEHSFABPe
reaction: metaR LALDO2x
reaction: metaR O16G1e
species: metaM 6hoxmelatn c
species: metaM arachcoa m
species: metaM hs deg3 l
reaction: metaR LPS4e
reaction: metaR EX prostgi2 LPAREN e RPAREN
reaction: metaR TRPATB0tc
reaction: metaR CRNt
reaction: metaR FACOAL200
species: metaM malthp e
species: metaM lac L c
reaction: metaR LPASE
reaction: metaR AG13T16g
species: metaM 3tetd7ecoacrn e
species: metaM 1p3h5c m
reaction: metaR FUT911g
species: metaM acgam c
reaction: metaR r2193
reaction: metaR GLYOX
species: metaM clpndcoa x
species: metaM undcoa m
species: metaM ksi pre27 g
species: metaM homoval m
species: metaM val L c
species: metaM ksii core2 deg2 l
reaction: metaR r0558
reaction: metaR EX CE5867 LPAREN e RPAREN
reaction: metaR SCP21cx
species: metaM psylchol e
species: MODEL1310110020#
species: metaM 5adtststerone r
species: metaM pi r
reaction: metaR r0645
species: metaM dc2coa x
species: metaM lgnccoa x
reaction: metaR KYNATESYN
reaction: metaR r0580
species: metaM 35cgmp c
reaction: metaR PROSTGH2t
reaction: metaR r0081
species: metaM crn x
reaction: metaR TTDCAFATPc
reaction: metaR APOC LYS BTNPm
reaction: metaR KHK
reaction: metaR ACITL
reaction: metaR S4TASE2ly
reaction: metaR PETHCT
reaction: metaR EX urea LPAREN e RPAREN
reaction: metaR TRDR2
reaction: metaR r1801
species: metaM dhcholestanate r
reaction: metaR r2083
species: metaM mi145p c
reaction: metaR HEX1
species: metaM lnlc e
species: metaM ksii core2 pre10 g
species: metaM HC00591 c
reaction: metaR r1731
reaction: metaR r1626
reaction: metaR GALASE9ly
reaction: metaR GALU
reaction: metaR HMGCOAtm
species: metaM succoa x
reaction: metaR GUAPRT
reaction: metaR NDP3ex
species: metaM acac m
reaction: metaR PPItm
reaction: metaR r2081
species: metaM HC01223 m
reaction: metaR r1624
reaction: metaR UGT1A10r
species: metaM ala D c
reaction: metaR r2199
species: metaM coa m
reaction: metaR GLYLEUHYDROc
reaction: metaR r1301
reaction: metaR THYMDtm

metaR r0853
reactant: MODEL1310110020#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is: SBO:0000185
name: Facilitated diffusion
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5b268f0c_006d_4211_b583_033b0f2b4baf
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8733
name: GPAA1
constant: false
initial concentration: NaN
boundary condition: true
is: O43292

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1c46bc60_1d38_4112_a1ed_a44890256d11
is encoded by: hsa:377841
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ENTPD8
is: Q5MY95

metaM ppi e
is: HMDB00250
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
is: CHEBI:33019
constant: false
name: Diphosphate
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110020#_6e387e78_2d19_4003_aa95_1da598796d7f
has only substance units: false
name: MYO5B
is: Q9H6Y6
type: Species
is encoded by: hsa:4645
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_1c013ad5_5f0a_4e5b_afba_c69f67fee59a
boundary condition: true
constant: false
is: SBO:0000252
name: ALDOA
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:226
type: Species

metaM hxan c
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: Hypoxanthine
has only substance units: false
is: HMDB00157
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: C00262
is: CHEBI:17368

metaR RE2659R
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000

metaM tchola x
type: Species
is: CHEBI:36257
initial amount: NaN
initial concentration: 1.0
name: taurocholate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
has only substance units: false
constant: false

metaM ipdp x
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: CHEBI:128769
boundary condition: false
name: isopentenyl diphosphate(3-)
is: HMDB01347
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_a3056c76_f5d4_4a56_9625_d544e76e1c01
has only substance units: false
is encoded by: hsa:84889
type: Species
is: SBO:0000252
boundary condition: true
is: Q8WY07
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC7A3

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaM arach c
is: CHEBI:32360
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
type: Species
name: arachidate
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_301d1f34_8242_481f_95d7_f454b285564f
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P19404
initial amount: NaN
boundary condition: true
is encoded by: hsa:4729
name: NDUFV2
is: SBO:0000252

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
name: RE3050
product: MODEL1310110020#
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110020#

metaR PI45P5P
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
modifier: MODEL1310110020#
reactant: MODEL1310110020#

metaR r0639
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
type: Reaction
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM retinol cis 11 e
is: CHEBI:16302
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
has only substance units: false
name: 11-cis-retinol
is: HMDB06216

metaR ACACT1x
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110020#
product: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_e78b6f70_e9e3_4900_9577_8bce8bda9566
is: Q05932
has only substance units: false
boundary condition: true
constant: false
type: Species
name: FPGS
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2356
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_d87cbb24_2aad_47e8_a71f_49f69eb1a8b0
constant: false
boundary condition: true
has only substance units: false
is: B3KU59
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC8A3
is encoded by: hsa:6547

http://identifiers.org/biomodels.db/MODEL1310110020#_def12d19_787d_4a25_bbdf_7e935bb8b2f2
initial concentration: NaN
name: PIGN
is encoded by: hsa:23556
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaM na1 x
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
type: Species
is: CHEBI:29101
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00588
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_784783b7_dfca_4f70_b811_d891e7e25aa2
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: GALNTL2
boundary condition: true
initial concentration: NaN
is: Q8N3T1
is encoded by: hsa:117248
initial amount: NaN

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_30fc10a1_0b12_416b_b0a9_04019d886840
is encoded by: hsa:220
type: Species
constant: false
is: P47895
initial concentration: NaN
is: SBO:0000252
name: ALDH1A3
initial amount: NaN
has only substance units: false
boundary condition: true

metaR FORtr
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
fast: false
reversible: true
is: SBO:0000185
name: FOR transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110020#_f4650bfa_c84a_40ef_8932_973e65d5eb30
name: B3GNT2
initial amount: NaN
boundary condition: true
is encoded by: hsa:10678
type: Species
has only substance units: false
initial concentration: NaN
is: Q9NY97
constant: false
is: SBO:0000252

metaM 5adtststerone r
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
initial concentration: 1.0
type: Species
constant: false

metaM 5dpmev c
initial concentration: 1.0
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: (R)-5-Diphosphomevalonate
is: HMDB01090

http://identifiers.org/biomodels.db/MODEL1310110020#_552cdd50_c57d_45dc_b710_0dd6a781dde6
is: SBO:0000252
initial amount: NaN
name: ATP1B3
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:483
has only substance units: false
is: P54709

metaR MG2er
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_921af389_7560_421a_8aa1_41b0c916c4b4
initial concentration: NaN
name: NDUFB5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4711
boundary condition: true
is: O43674

http://identifiers.org/biomodels.db/MODEL1310110020#_4fac9776_ed9a_4924_a9f5_7dd793b6b471
is encoded by: hsa:83715
initial amount: NaN
name: ESPN
is: SBO:0000252
is: B1AK53
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_a88d4c4c_9753_4408_b09d_d087692ccfc3
is encoded by: hsa:48
name: ACO1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P21399
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR CHSTEROLt2
is: SBO:0000185
is described by: ECO:0000000
name: cholesterol intracellular transport
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_d29a732a_0351_4992_bba5_fca3f69147d0
name: INPP5B
is: P32019
initial concentration: NaN
is encoded by: hsa:3633
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaM stcoa c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
is: C00412
is: HMDB01114
initial concentration: 1.0
constant: false
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
boundary condition: false
is: CHEBI:57394

metaR S6T4g
type: Reaction
reactant: MODEL1310110020#
reversible: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110020#

metaM ksi deg3 l
constant: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:30825
boundary condition: false
name: keratan sulfate I, degradation product 3
is: HMDB00573
type: Species
initial amount: NaN

metaR 4PYRDX
product: MODEL1310110020#
type: Reaction
name: 4-Pyridoxal secretion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaM r5p c
is: CHEBI:18189
type: Species
is: C00117
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
has only substance units: false

metaR P45027A11m
reversible: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is: SBO:0000176
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_3190d52a_ebdd_401d_a5eb_eba09226e073
is: SBO:0000252
is encoded by: hsa:206358
name: SLC36A1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: Q1LZ56
has only substance units: false

metaR r1012
kinetic law: MODEL1310110020#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false
name: Postulated transport reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:

metaM 4izp c
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01014
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
name: 4-Imidazolone-5-propanoate
has only substance units: false
is: CHEBI:57255

metaM na1 r
initial amount: NaN
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
type: Species
is: CHEBI:29101
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00588

metaR C81CRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_6baf3cdc_f7c6_47a4_a79b_27649814d49d
boundary condition: true
initial amount: NaN
constant: false
name: ASNS
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: B4DXZ1
is encoded by: hsa:440

metaR MI1345PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110020#
is described by: ECO:0000269
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_13dbf1c4_60ad_41f9_8244_c1252fc1d524
constant: false
is: SBO:0000252
initial concentration: NaN
name: HSD3B7
initial amount: NaN
is encoded by: hsa:80270
is: Q9H2F3
has only substance units: false
boundary condition: true
type: Species

metaM HC00718 c
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial amount: NaN
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
type: Species

metaM arab L e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
initial amount: NaN
is: HMDB00646
name: L-arabinose
boundary condition: false
constant: false
is: CHEBI:30849

metaR PROGLYPEPT1tc
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0311
kinetic law: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
modifier: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000

metaM decdicoa c
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: decadienoylcoa
is: HMDB01168

metaR HSAT2ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#

metaM 2mp2coa m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:27754
constant: false
is: HMDB01011
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_9140b2eb_3ad9_47d4_9d13_36721ad27907
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6NZ59
is: SBO:0000297
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110020#_308764f8_d1ce_4414_8fb9_724c1f233395
type: Species
constant: false
is encoded by: hsa:BE042354
name: _BE042354_1_m
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM hmgcoa x
has only substance units: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
type: Species
is: CHEBI:15467
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
initial amount: NaN

metaM 3thexddcoacrn e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H41NO5 CHARGE: 0
initial amount: NaN
constant: false
is: HMDB02014
initial concentration: 1.0
boundary condition: false
type: Species
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine

metaR r1011
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
is: SBO:0000185

metaR DTMPK
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
name: dTMP kinase

http://identifiers.org/biomodels.db/MODEL1310110020#_3befdb50_ed15_4ca6_a6ca_cade886eb273
is: Q9UKM7
name: MAN1B1
is encoded by: hsa:11253
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_3fb393ee_d2b3_4557_a8d8_07efeb73fe40
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P04066
is encoded by: hsa:2517
name: FUCA1
constant: false
type: Species

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR CHSTEROLt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
kinetic law: MODEL1310110020#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
name: cholesterol intracellular transport
is: SBO:0000185
product: MODEL1310110020#

metaM ppcoa m
initial concentration: 1.0
is: HMDB01275
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
type: Species
is: SBO:0000247
is: CHEBI:57392
boundary condition: false
is: C00100

http://identifiers.org/biomodels.db/MODEL1310110020#_90e3f155_13dd_488e_91da_70b91bfc18b7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:H53099
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _H53099_1_m
constant: false

metaM ksi pre7 g
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00175
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 7
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
constant: false
is: C00130
initial concentration: 1.0

metaR G6Pter
kinetic law: MODEL1310110020#
is described by: ECO:0000269
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
reactant: MODEL1310110020#
product: MODEL1310110020#

metaR r0522
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110020#
fast: false
reversible: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
is: SBO:0000176
type: Reaction

metaM 5thf m
boundary condition: false
has only substance units: false
constant: false
type: Species
is: C00440
is: HMDB01396
initial amount: NaN
name: pentaglutamyl folate (THF)
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110020#_2f4c92ca_207a_4f31_af5a_b2b8216565f8
initial concentration: NaN
name: GART
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2618
type: Species
is: Q59HH3
initial amount: NaN
constant: false
has only substance units: false

metaM eipencoa x
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
name: 2,5,8,11,14-eicosapentaenoylcoa
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial amount: NaN

metaM 3tetd7ecoa c
constant: false
is: HMDB05066
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
name: 3-hydroxy tetradecenoyl-7-coa
is: SBO:0000247

metaM acrn r
initial amount: NaN
is: HMDB00201
type: Species
is: CHEBI:57589
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: O-acetylcarnitine
is: SBO:0000247

metaR CYSO
modifier: MODEL1310110020#
is: SBO:0000176
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269
name: cysteine oxidase
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.13.11.20
type: Reaction
reversible: false

metaR EX progly LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for prolyl-glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_571daa72_6566_4d53_bb16_3a09b556a388
is encoded by: hsa:8659
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALDH4A1
boundary condition: true
type: Species
has only substance units: false

metaR PRO1x
reversible: false
modifier: MODEL1310110020#
product: MODEL1310110020#
name: L-ProlineNAD+ 5-oxidoreductase
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
is described by: ECO:0000134
fast: false
is: SBO:0000176
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR r1010
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
name: Postulated transport reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction

metaR BHBt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
is: SBO:0000185
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
product: MODEL1310110020#

metaR HEX4
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
kinetic law: MODEL1310110020#
name: hexokinase (D-mannose:ATP)
product: MODEL1310110020#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
reactant: MODEL1310110020#
reversible: false
type: Reaction

metaR AMPTASECGe
name: alanyl aminopeptidase (cys-gly) (e)
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.4.11.2
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES:SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly
reactant: MODEL1310110020#
reversible: false

metaR C4x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR OCTDECE1CRNe
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaR 3DPHBH1
product: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
is: SBO:0000176
reversible: false
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)

metaR CHSTEROLt1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
kinetic law: MODEL1310110020#
name: cholesterol intracellular transport
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000304
product: MODEL1310110020#
modifier: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_a84bd271_bf6f_4879_bedd_27b75cf5283b
constant: false
is: P11310
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ACADM
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110020#_7a84e584_f71f_41fe_ab1f_6b6e645e8291
is encoded by: hsa:506
is: SBO:0000252
constant: false
boundary condition: true
is: P06576
initial concentration: NaN
initial amount: NaN
type: Species
name: ATP5B
has only substance units: false

metaR CRVNCtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110020#
type: Reaction
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#
reversible: true
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110020#_e4e20e70_802b_4bd9_8df5_65b680dfb2c8
constant: false
is encoded by: hsa:3033
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: HADH
type: Species
initial concentration: NaN
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110020#_8b22af45_393a_420c_bd6a_36756b028d99
is: SBO:0000252
name: PLCB1
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23236
type: Species
has only substance units: false
is: Q9NQ66

metaM 5thf l
is: HMDB01396
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:3729
is: C00440
boundary condition: false
initial amount: NaN
name: pentaglutamyl folate (THF)
is: SBO:0000247

metaR r2519
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
reactant: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
name: Utilized transport
fast: false

metaR r0523
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is: SBO:0000176
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110020#
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110020#

metaM arab L c
has only substance units: false
constant: false
is: CHEBI:30849
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species
name: L-arabinose
initial amount: NaN
boundary condition: false
is: HMDB00646

metaM c12dc c
boundary condition: false
is: HMDB00623
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: dodecanedioyl carnitine
is: SBO:0000247
has only substance units: false

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06927
constant: false
name: 4-Methylzymosterol intermediate 1
initial concentration: 1.0

metaM maltttr e
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5141
type: Species
name: Maltotetraose
is: C02052
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_838cf618_55e4_436a_a441_ec3d1b233cff
is encoded by: hsa:788
initial concentration: NaN
name: SLC25A20
is: SBO:0000252
constant: false
initial amount: NaN
is: O43772
has only substance units: false
type: Species
boundary condition: true

metaM succ x
name: Succinate
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: CHEBI:30031
boundary condition: false
initial concentration: 1.0
constant: false
is: C00042
is: HMDB00254

metaM 3dodtricoa m
initial concentration: 1.0
name: 3,6,9-dodecatrienoylcoa
constant: false
is: SBO:0000247
is: C05279
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123
type: Species

metaM taxol c
boundary condition: false
is: C07394
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:45863
has only substance units: false
is: SBO:0000247
notes: FORMULA: C47H31NO14 CHARGE: 0 INCHI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
name: paclitaxel

metaM ach n
initial concentration: 1.0
boundary condition: false
is: CHEBI:15355
has only substance units: false
type: Species
name: acetylcholine
is: SBO:0000247
is: HMDB00895
constant: false
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110020#_083d894c_ea62_4aa8_b82e_c7d1997caab3
name: LCT
is: SBO:0000252
is encoded by: hsa:3938
has only substance units: false
constant: false
boundary condition: true
type: Species
is: P09848
initial amount: NaN
initial concentration: NaN

metaR ADRNt
product: MODEL1310110020#
type: Reaction
reactant: MODEL1310110020#
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110020#

metaM lac D e
has only substance units: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
name: (R)-lactate
constant: false
is: CHEBI:16004
initial concentration: 1.0
is: HMDB01311
initial amount: NaN
is: SBO:0000247

metaM pacald c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB06236
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
name: phenylacetaldehyde
is: CHEBI:16424

http://identifiers.org/biomodels.db/MODEL1310110020#_9ebad5a8_c9c9_402c_88a5_6934d0962886
constant: false
has only substance units: false
initial amount: NaN
is: O75715
name: GPX5
is encoded by: hsa:2880
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM m8masn r
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: C05876
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C70H117N2O55X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110020#_056705f1_4bf6_4431_9e8f_6447f01bc3c1
initial concentration: NaN
constant: false
is: SBO:0000252
is: P00480
type: Species
name: OTC
has only substance units: false
is encoded by: hsa:5009
initial amount: NaN
boundary condition: true

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM noncoa m
boundary condition: false
type: Species
name: nonanoylcoa
initial amount: NaN
initial concentration: 1.0
is: C01942
has only substance units: false
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
is: HMDB13028
is: SBO:0000247
constant: false

metaR C180CRNt
is described by: ECO:0000269
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
product: MODEL1310110020#
type: Reaction
fast: false
is: SBO:0000185
name: C180 transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
modifier: MODEL1310110020#

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:61405

metaM CE1936 e
initial concentration: 1.0
name: spermine dialdehyde
has only substance units: false
boundary condition: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
is: CHEBI:36781
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR DGNSKm
type: Reaction
fast: false
kinetic law: MODEL1310110020#
reversible: false
is: SBO:0000176
product: MODEL1310110020#
name: deoxyguanosine kinase
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.113
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is described by: ECO:0000269

metaR BTNDe
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110020#
name: biotinidase (biotin), extracellular
is: SBO:0000176
type: Reaction
product: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT

metaR FAOXC226
modifier: MODEL1310110020#
reactant: MODEL1310110020#
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110020#
product: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_d4e4b4a7_c12c_4483_8ce4_4157816a10be
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: SLC6A8
boundary condition: true
is: B4DIA3
is encoded by: hsa:6535
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_be46b0ff_e097_40b4_a43f_175f3a0dbdea
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:M68895
is: SBO:0000252
constant: false
name: _M68895_1_c
initial amount: NaN
type: Species

metaR r0871
name: Diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
product: MODEL1310110020#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110020#

metaR r2514
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
name: Utilized transport
product: MODEL1310110020#

metaM ksi deg28 l
is: HMDB00812
initial amount: NaN
is: CHEBI:16953
type: Species
initial concentration: 1.0
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
has only substance units: false
name: keratan sulfate I, degradation product 28
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_4efc2040_0a8f_4880_a544_01fe467866bc
is encoded by: hsa:6526
type: Species
name: SLC5A3
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: P53794
is: SBO:0000252

metaR 3AIBtm
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: 3-amino-isobutyrate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110020#_c68a7f9d_ebc4_4a74_a285_758ce0c8ee1a
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: NDUFS6
is encoded by: hsa:4726
is: Q6IBC4
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM crn r
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: (R)-carnitine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: CHEBI:16347
is: HMDB00062

metaR C4STMO2Pr
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
is: SBO:0000176
type: Reaction
fast: false
name: C-4 methyl sterol oxidase
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
product: MODEL1310110020#
kinetic law: MODEL1310110020#

metaR FACOAL206
is described by: ECO:0000269
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110020#
product: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#

metaM c12dccoa c
initial amount: NaN
name: dodecanedioylcoa
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: HMDB00623
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_4a13cce2_8ae4_4e5d_a950_f3f9cda449ec
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
name: GGT1
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR GALSIDEtl
name: galactocerebroside intracellular transport
is described by: ECO:0000000
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ

metaM HC00900 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:30860
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial amount: NaN
has only substance units: false
constant: false
name: Methylmalonate
type: Species

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
name: Facilitated diffusion
reversible: true
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
modifier: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.4.13
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR HDCACBP
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR B3GNT31g
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
is described by: ECO:0000269

metaR ABO9g
product: MODEL1310110020#
is described by: ECO:0000269
reversible: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
reactant: MODEL1310110020#

metaR r0545
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110020#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110020#
type: Reaction

metaR RE3421R
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
name: RE3421
product: MODEL1310110020#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110020#
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000176

metaR G5SDym
name: glutamate-5-semialdehyde dehydrogenase (m)
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
is: SBO:0000176
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.41
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110020#

metaM 3dhguln c
constant: false
is: HMDB06334
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57655
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_9d5bb6e8_3993_460f_a692_004d004c3e08
is encoded by: hsa:51251
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NT5C3
is: Q9H0P0
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR ORNtiDF
reversible: false
is: SBO:0000185
name: ornithine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
type: Reaction
modifier: MODEL1310110020#
fast: false
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR FACOAL205
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110020#
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110020#
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_8da8c392_8546_43f0_9f6d_1181bc32852d
is encoded by: hsa:2530
has only substance units: false
name: FUT8
is: Q9BYC5
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r2516
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FAOXC163C164Gm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR FAOXTC122TC101m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR CO2tm
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
type: Reaction
name: CO2 transport (diffusion), mitochondrial

metaR RE1804M
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110020#
modifier: MODEL1310110020#
type: Reaction
kinetic law: MODEL1310110020#
name: RE1804
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15

http://identifiers.org/biomodels.db/MODEL1310110020#_d0627d83_fcf7_45d5_b732_63e248d27e5d
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: P00966
is encoded by: hsa:445
name: ASS1
initial concentration: NaN
type: Species
constant: false

metaR MM6B2g
reactant: MODEL1310110020#
product: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110020#_a76ad16e_3b9c_4f1b_bdef_64839e8ace90
is: Q99643
initial amount: NaN
has only substance units: false
is encoded by: hsa:6391
is: SBO:0000252
name: SDHC
constant: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110020#_786b6f6f_8b03_401c_9b4d_4a16251613cf
name: SCP2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: C9JC79
is encoded by: hsa:6342

metaR DECDPtm
is: SBO:0000185
fast: false
reactant: MODEL1310110020#
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110020#
product: MODEL1310110020#

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110020#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
modifier: MODEL1310110020#
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT

metaM CE4794 m
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110020#_bf991ab5_acfc_4602_85ab_32569aa5c279
type: Species
is encoded by: hsa:27165
constant: false
has only substance units: false
is: Q9UI32
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GLS2

metaR RE2759X
reversible: true
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
type: Reaction
is: SBO:0000176
name: RE2759
fast: false
is version of: http://identifiers.org/ec-code/5.1.99.4
reactant: MODEL1310110020#

metaM glc D r
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
constant: false
name: D-glucose
initial amount: NaN
is: HMDB00122
is: CHEBI:4167
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_98fbcf28_ba57_4462_9375_6badf4d69f42
name: UGDH
is: O60701
type: Species
constant: false
is encoded by: hsa:7358
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_fab97061_99e0_4e8c_81a8_09af2ce7b2bd
is: P04062
initial amount: NaN
is encoded by: hsa:2629
is: SBO:0000252
type: Species
name: GBA
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM 2hexdtricoa x
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species

metaR RE2649C
type: Reaction
modifier: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
name: RE2649
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true

metaM Lpipecol x
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-pipecolic acid
is: HMDB00716
boundary condition: false
is: CHEBI:30913
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
has only substance units: false

metaR CYTK9n
modifier: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP),nuclear
fast: false
is: SBO:0000176
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0317
type: Reaction
product: MODEL1310110020#
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: CO2 peroxisomal transport
type: Reaction
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
product: MODEL1310110020#
is described by: ECO:0000000
reversible: true

metaR r2511
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is described by: ECO:0000000
name: Utilized transport
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaM galacglcgalgbside hs e
is: SBO:0000247
constant: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
type: Species
boundary condition: false
is: C00124
is: CHEBI:0
has only substance units: false
initial concentration: 1.0
name: Gal-GlcNAc-Gal globoside

metaR FAOXC205C185m
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR FACOAL203
modifier: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_9039b88c_3389_4e23_8d94_c5059e448046
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: P26439
name: HSD3B2
initial concentration: NaN
is encoded by: hsa:3284
boundary condition: true
is: SBO:0000252

metaR AG13T14g
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110020#
kinetic law: MODEL1310110020#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110020#
is: SBO:0000176

metaR r2510
is described by: ECO:0000000
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false
reversible: true
name: Utilized transport
type: Reaction
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185

metaM dsmsterol r
is: CHEBI:17737
is: HMDB02719
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
type: Species
initial amount: NaN
name: desmosterol
has only substance units: false

metaM xoldioloneh c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: CHEBI:2288
initial concentration: 1.0
boundary condition: false
is: HMDB06887
type: Species
has only substance units: false
is: SBO:0000247
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_93485371_bdfa_41b6_bee4_0be1b4b68666
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q9ULC5
name: ACSL5
is encoded by: hsa:51703
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_41af6337_9676_4b04_ba13_3d187679284e
is: Q5SYN6
constant: false
name: SLC22A3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6581

metaM arachcrn c
is: SBO:0000247
is: HMDB06460
name: arachidyl carnitine
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
type: Species
initial concentration: 1.0
has only substance units: false

metaM taxol e
is: C07394
name: paclitaxel
constant: false
notes: FORMULA: C47H31NO14 CHARGE: 0 INCHI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:45863
is: SBO:0000247
has only substance units: false
type: Species

metaM fmn c
boundary condition: false
is: CHEBI:58210
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
initial amount: NaN
is: C00061
name: FMN
is: HMDB01520
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_3a5cd18b_1f89_46a6_904c_9ebb8bebf5ee
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10026
name: PIGK
is: Q92643

metaM succoa c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01022
type: Species
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
constant: false
has only substance units: false
name: Succinyl-CoA

metaR r0541
type: Reaction
reversible: true
reactant: MODEL1310110020#
is described by: ECO:0000000
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110020#
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110020#_e8184678_e5ee_4f29_97b3_c357bdb2deaa
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8897
constant: false
boundary condition: true
name: MTMR3
has only substance units: false
is: SBO:0000252

metaM lac D c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB01311
has only substance units: false
name: (R)-lactate
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004

http://identifiers.org/biomodels.db/MODEL1310110020#_8eebad60_dff0_44e2_bf85_2a3c3d2aca92
initial concentration: NaN
is: SBO:0000252
name: PDE11A
type: Species
is: Q9HCR9
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:50940

metaR UREAtm
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
name: Urea transport via diffusion
kinetic law: MODEL1310110020#
modifier: MODEL1310110020#
fast: false
reversible: true
is described by: ECO:0000304

metaR TAGAT Dt
name: D-tagatose uptake via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110020#_9dda05fe_3bd4_495f_a4f4_8f183762276e
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q05C14
has only substance units: false
is encoded by: hsa:2352
name: FOLR3
initial amount: NaN

metaM galacglcgalgbside hs g
initial amount: NaN
type: Species
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174
name: Gal-GlcNAc-Gal globoside
has only substance units: false

metaM oagt3 hs g
is: CHEBI:58367
is: HMDB00286
is: SBO:0000247
is: C00029
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
name: 9-O-Acetylated GT3
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_67ba289b_a7d4_4800_99df_94c8c3826b2d
type: Species
has only substance units: false
initial amount: NaN
name: B3GALNT1
is encoded by: hsa:8706
is: SBO:0000252
is: Q49AT3
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_ceef90ef_4215_4abe_bccd_6de39db07a02
initial amount: NaN
name: _AI824319_1_r
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI824319
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_6e4d70c8_307e_4226_ac38_aaff092f4ae0
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000297
constant: false
has part: E7EX19
initial amount: NaN
name: PIK3CD:PIK3R1
has only substance units: false
is encoded by: hsa:5295

metaM citr L m
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
is: CHEBI:16349
name: L-citrulline
has only substance units: false
is: HMDB00904
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_355d9b34_a953_4f1d_a390_c6f02b0d77f5
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:493
is: P23634
name: ATP2B4
type: Species

metaR NAt3 1
name: sodium proton antiporter (H:NA is 1:1)
product: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#
is described by: ECO:0000269
fast: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM ala B m
is: CHEBI:16958
initial amount: NaN
name: beta-alanine
is: HMDB00056
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

http://identifiers.org/biomodels.db/MODEL1310110020#_eafdd99e_f6b5_4f12_aa3e_95980d8456bd
is encoded by: hsa:23563
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CHST5
constant: false

metaM clpnd c
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:53488
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06528
has only substance units: false
initial amount: NaN
name: clupanodonic acid

http://identifiers.org/biomodels.db/MODEL1310110020#_56f58dcf_0d5e_43af_9578_ebf481c0d9f6
type: Species
boundary condition: true
has only substance units: false
name: GPX7
constant: false
is encoded by: hsa:2882
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96SL4

metaR FACOAL200
modifier: MODEL1310110020#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110020#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110020#
fast: false
product: MODEL1310110020#
is: SBO:0000176
type: Reaction

metaR r1008
is: SBO:0000185
name: Facilitated diffusion
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110020#
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_1c98ee21_5fb2_438c_8816_8a001351a0ed
is encoded by: hsa:54872
type: Species
name: PIGF:PIGG
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
has part: Q8NCI4
initial concentration: NaN
constant: false

metaR r0973
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110020#
reversible: true
reactant: MODEL1310110020#
fast: false
kinetic law: MODEL1310110020#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion

metaM HC01434 m
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
type: Species
name: oxalatosuccinate(3-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM CE2915 e
notes: FORMULA: C44H60N7O11 CHARGE: -1 INCHI: InChI=1/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/p-1/t26-,30-,31+,32+,33-,34+,36-,37-/m1/s1 EHMN_ABBREVIATION: CE2915
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C01936
initial concentration: 1.0
name: beta-casomorphin
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN

metaM Asn X Ser Thr r
type: Species
is: HMDB00051
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:28938
is: C01342
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110020#_893e93cb_94c0_4aa9_8d48_35540ffabc5b
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: GPX2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2877
is: P18283
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_2baee35b_6325_425b_902b_09998c873d1a
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:114134
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC2A13
is: Q96QE2

metaM HC02179 e
constant: false
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 20-hydroxy-arachidonate
type: Species
initial concentration: 1.0
is: CHEBI:34306

metaR ELAIDCPT2
modifier: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110020#
name: carnitine transferase

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110020#
reactant: MODEL1310110020#
is: SBO:0000176
kinetic law: MODEL1310110020#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
modifier: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false

metaR r1423
is: SBO:0000185
fast: false
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
product: MODEL1310110020#
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_eb0b057c_6786_4572_9a30_084fe479caa9
has only substance units: false
name: TDO2
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: P48775
is encoded by: hsa:6999

metaR FBA4
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110020#
is: SBO:0000176
fast: false

metaM lgnccoa c
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06526
name: lignocericyl coenzyme A
boundary condition: false
type: Species
has only substance units: false

metaM arachcrn m
is: HMDB06460
type: Species
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110020#_6fefd24b_7634_4678_be71_536fa04e63d3
name: BAAT
is encoded by: hsa:570
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q14032
boundary condition: true

metaM c12dc x
initial concentration: 1.0
initial amount: NaN
name: dodecanedioyl carnitine
has only substance units: false
boundary condition: false
is: C05279
is: SBO:0000247
is: HMDB11123
type: Species
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false

metaR C6CRNtcx
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR FAOXC102C101x
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR GALSIDEtg
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reversible: true
name: galactocerebroside intracellular transport
product: MODEL1310110020#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110020#_b9a49090_a979_45b1_9089_571a7bb55601
is encoded by: hsa:6916
is: Q53F23
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: TBXAS1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_3d9a24bc_c9ec_4b8f_88f1_f33538061f0f
constant: false
initial amount: NaN
name: FDFT1
initial concentration: NaN
is encoded by: hsa:2222
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P37268
type: Species

http://identifiers.org/biomodels.db/MODEL1310110020#_c3631eff_359e_4b84_914f_56dcd2920660
constant: false
boundary condition: true
has only substance units: false
name: FOLR1
type: Species
is: P15328
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
initial concentration: NaN

metaM 2hexdtricoa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB02288

metaR THP2Ctp
kinetic law: MODEL1310110020#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false
is described by: ECO:0000000
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
reactant: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110020#_b16ac272_021a_44b8_a6a6_30fb4b0782f6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC27A3
initial amount: NaN
is encoded by: hsa:11000
type: Species
is: Q5K4L6
has only substance units: false
constant: false

metaR r0425
reactant: MODEL1310110020#
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
name: EC:1.1.1.42
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110020#
type: Reaction
modifier: MODEL1310110020#

metaR ADEt
kinetic law: MODEL1310110020#
name: adenine reversible transport, cytosol
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110020#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110020#
reactant: MODEL1310110020#

metaM chol c
is: CHEBI:15354
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: HMDB00097
type: Species
is: C00114
name: Choline
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_62a6a7b1_f2bd_4ab0_b5c6_8fb691273632
name: BDH1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:622
is: SBO:0000252

metaR THCHOLSTOICtm
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110020#
reversible: true
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_5b159a4a_2ee5_42a8_85b2_e7bc3d5ddc6d
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: ADH1C
constant: false
is: P00326
initial concentration: NaN
is encoded by: hsa:126
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110020#_7fa86ce8_4869_423c_875f_8abc3fd9d7a8
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1103
is: D3DX95
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CHAT

metaM oagt3 hs e
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18421
is: HMDB02168
name: 9-O-Acetylated GT3
type: Species
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110020#_fd080f28_cb97_4b94_8f99_9a8655cf0499
is encoded by: hsa:29925
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: GMPPB
has only substance units: false
constant: false
is: SBO:0000252

metaR B3GNT311g
type: Reaction
reactant: MODEL1310110020#
is: SBO:0000176
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
product: MODEL1310110020#
kinetic law: MODEL1310110020#
reversible: false
modifier: MODEL1310110020#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ

metaR r0650
type: Reaction
product: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110020#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110020#
is: SBO:0000176

metaR ORNTArm
fast: false
reactant: MODEL1310110020#
modifier: MODEL1310110020#
is described by: ECO:0000269
product: MODEL1310110020#
name: ornithine transaminase reversible (m)
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
reversible: true
kinetic law: MODEL1310110020#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.13
type: Reaction

metaM acrn c
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
name: O-acetylcarnitine
initial amount: NaN
type: Species
is: CHEBI:57589
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00201

http://identifiers.org/biomodels.db/MODEL1310110020#_bef499cc_d2b1_44d8_921d_f4139f22836d
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:137872
is: Q8IWW8
name: ADHFE1
is: SBO:0000252

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
constant: false

metaM pydxn c
is: CHEBI:16709
initial concentration: 1.0
constant: false
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false
type: Species
name: Pyridoxine
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00239
is: C00314

http://identifiers.org/biomodels.db/MODEL1310110020#_3bfade4d_30b8_4ce8_9d97_0faeabcf254b
has only substance units: false
name: SLCO1C1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:53919
boundary condition: true
is: Q5JPA4

metaM nrpphrsf e
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: Sulfate derivative of norepinephrine
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
type: Species
is: SBO:0000247

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
reactant: MODEL1310110020#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110020#
kinetic law: MODEL1310110020#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110020#

metaR UDPtl
product: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: udp intracellular transport
reversible: true
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110020#_bba2bef2_5235_459c_ad49_58efd0bfcf6e
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: P36969
name: GPX4
has only substance units: false
is encoded by: hsa:2879
initial concentration: NaN
initial amount: NaN

metaR NADtpu
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
type: Reaction
reversible: false
name: NAD transporter, peroxisome
fast: false
reactant: MODEL1310110020#
kinetic law: MODEL1310110020#
is: SBO:0000185
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_14e26e6a_e25f_4561_84cc_e46c9fbb4749
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:28
type: Species
initial amount: NaN
is: P16442
has only substance units: false
name: ABO

metaM glyc S c
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O4 CHARGE: 0
is: HMDB06372
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:33871
has only substance units: false
name: (S)-Glycerate

metaR FAOXC10C10OHm
kinetic law: MODEL1310110020#
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110020#_1bf3080f_d2eb_4f8c_bc13_59e137b4ea78
is: Q9Y2C3
boundary condition: true
is: SBO:0000252
name: B3GALT5
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10317

http://identifiers.org/biomodels.db/MODEL1310110020#_bbbd42e5_e563_449f_bf58_5543326fd04a
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:113026
name: PLCD3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q8N3E9
is: SBO:0000252

metaR PACCOAL
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: phenylacetate-CoA ligase
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110020#
reversible: false
fast: false
kinetic law: MODEL1310110020#
product: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_bbc98cd4_0f0b_451f_a618_489d75a8acce
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM na1 e
initial amount: NaN
is: CHEBI:4541
is: HMDB00588
is: SBO:0000247
initial concentration: 1.0
is: C01330
notes: FORMULA: Na CHARGE: 1
boundary condition: false
name: Sodium
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110020#_c28a218b_be41_4763_a12f_c25baa94546b
is: SBO:0000252
boundary condition: true
is encoded by: hsa:518
name: ATP5G3
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaR FBA5
product: MODEL1310110020#
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (229.1) SUBSYSTEM: Galactose metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reactant: MODEL1310110020#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110020#
name: D-Tagatose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is described by: ECO:0000269
modifier: MODEL1310110020#

http://identifiers.org/biomodels.db/MODEL1310110020#_49a8a3b0_3d76_4e79_9634_794a4b0d3070
name: _AI601100_1_m
has only substance units: false
type: Species
is encoded by: hsa:AI601100
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110020#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM od2coa m
boundary condition: false
is: SBO:0000247
name: trans-Octadec-2-enoyl-CoA
initial amount: NaN
has only substance units: false
is: HMDB06529
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
initial concentration: 1.0
type: Species
is: CHEBI:50570
constant: false

metaM galacglcgalgbside hs c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: Gal-GlcNAc-Gal globoside
initial concentration: 1.0
is: HMDB00061
is: CHEBI:58343
type: Species
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: SBO:0000247

metaM oagt3 hs c
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 9-O-Acetylated GT3
is: HMDB00286
is: CHEBI:58367
is: C00029
type: Species
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110020#_06b453bb_912b_45d3_9287_d217145cbe27
initial amount: NaN
name: UCK1
initial concentration: NaN
is: Q5JT09
is encoded by: hsa:83549
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM CE5853 e
has only substance units: false
name: alpha-CEHC-glucuronide
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853

http://identifiers.org/biomodels.db/MODEL1310110020#_c449dc4f_740e_44ec_b45c_015907aae0f8
is: P36269
is encoded by: hsa:2687
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GGT5
is: SBO:0000252
type: Species
boundary condition: true

metaR r1801
name: Y+LAT2 Utilized transport
reactant: MODEL1310110020#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110020#
type: Reaction
product: MODEL1310110020#
modifier: MODEL1310110020#
is: SBO:0000185
is described by: ECO:0000000

metaM HC01361 e
type: Species
initial concentration: 1.0
is: CHEBI:17001
constant: false
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Dihydroneopterin
has only substance units: false

metaR r0652
type: Reaction
kinetic law: MODEL1310110020#
is described by: ECO:0000000
fast: false
product: MODEL1310110020#
reversible: true
modifier: MODEL1310110020#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110020#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176

metaR GNDer
kinetic law: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
product: MODEL1310110020#
reactant: MODEL1310110020#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: phosphogluconate dehydrogenase, endoplasmic reticulum

metaM citr L c
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
type: Species
boundary condition: false
initial concentration: 1.0
name: L-citrulline
is: SBO:0000247
has only substance units: false
is: CHEBI:16349
constant: false
initial amount: NaN

metaR RBK
modifier: MODEL1310110020#
name: ribokinase
fast: false
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.7.1.15
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110020#
is: SBO:0000176
product: MODEL1310110020#
reversible: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110020#
reactant: MODEL1310110020#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR G14T14g
type: Reaction
kinetic law: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110020#
reactant: MODEL1310110020#
is described by: ECO:0000000
modifier: MODEL1310110020#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176

W3 CDTF: Fri Aug 31 00:43:31 BST 2012

W3 CDTF: Fri Aug 31 00:43:32 BST 2012