metaR r2353
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110019#

metaR NDPK2m
is described by: ECO:0000254
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reactant: MODEL1310110019#
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
product: MODEL1310110019#

metaM so4 c
has only substance units: false
is: SBO:0000247
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
is: CHEBI:16189
type: Species

metaM duri n
initial amount: NaN
has only substance units: false
is: CHEBI:16450
constant: false
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: 2'-deoxyuridine
type: Species
is: HMDB00012
is: SBO:0000247
initial concentration: 1.0

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#

metaM prostge2 c
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01220
is: SBO:0000247
constant: false
name: prostaglandin E2(1-)
boundary condition: false
type: Species

metaR LEUt4
name: L-leucine transport in via sodium symport
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
modifier: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_be766664_cc26_4d56_84f9_7ca3d5775e14
initial amount: NaN
is encoded by: hsa:3613
has only substance units: false
type: Species
is: O14732
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: IMPA2

metaM ala D c
constant: false
initial amount: NaN
type: Species
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15570
is: SBO:0000247

metaR MTHFD2
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110019#
is described by: ECO:0000134
kinetic law: MODEL1310110019#
name: methylenetetrahydrofolate dehydrogenase (NAD)
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9

http://identifiers.org/biomodels.db/MODEL1310110019#_efcd5904_0d0f_49f1_8bf6_57ae809bb461
has only substance units: false
is: Q9NVS9
initial concentration: NaN
is encoded by: hsa:55163
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: PNPO

metaM HC02208 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d1
has only substance units: false
type: Species
is: CHEBI:27696
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_baf4a33a_cd24_4d0d_aec0_da41682d99b0
type: Species
boundary condition: true
name: _LOC374569_1_e
constant: false
has only substance units: false
is encoded by: hsa:LOC374569
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM coa e
has only substance units: false
type: Species
is: HMDB01423
name: Coenzyme A
boundary condition: false
is: C00010
initial amount: NaN
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_c20643f5_e135_4118_bf74_b145d285a795
initial amount: NaN
has only substance units: false
is encoded by: hsa:F23536
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: _F23536_1_m

metaM mi1345p c
boundary condition: false
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: SBO:0000247
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
has only substance units: false
is: CHEBI:57895
initial concentration: 1.0
is: HMDB01059
initial amount: NaN
type: Species

metaR r0301
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
reversible: false
name: Xanthosine-5-phosphate:ammonia ligase (AMP-forming) Purine metabolism EC:6.3.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.3.4.1 Confidence Level: 0 AUTHORS: PMID:6260205,PMID:6698284,PMID:7559506,PMID:7706277,PMID:8089153 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2b303616_0dc7_4902_9384_532ddd12d363
initial concentration: NaN
is encoded by: hsa:53919
constant: false
boundary condition: true
type: Species
name: SLCO1C1
initial amount: NaN
is: SBO:0000252
is: Q5JPA4
has only substance units: false

metaM h n
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: proton
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110019#_39ab6daf_e49a_454b_a6bc_16f40d3928b7
type: Species
constant: false
name: LTA4H
is: SBO:0000252
is encoded by: hsa:4048
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P09960
initial amount: NaN

metaM pro L e
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00162
name: L-proline
type: Species
constant: false
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0

metaR r0940
name: Free diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
type: Reaction
fast: false
reversible: true

metaM dcyt c
name: Deoxycytidine
is: C00881
initial concentration: 1.0
boundary condition: false
is: CHEBI:15698
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00014

http://identifiers.org/biomodels.db/MODEL1310110019#_0b05f80d_e9b7_4708_a225_0465754244e2
initial concentration: NaN
type: Species
is encoded by: hsa:195814
initial amount: NaN
is: B3KT84
boundary condition: true
name: SDR16C5
is: SBO:0000252
constant: false
has only substance units: false

metaR RE0830N
name: RE0830
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.96

http://identifiers.org/biomodels.db/MODEL1310110019#_c7947bae_f5f3_471d_b41c_f2ac0fb23294
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110019#_e7447aaa_98f4_4065_9b99_4b7504a4d5a4
constant: false
type: Species
initial amount: NaN
name: RDH11
is: B4DDW0
is encoded by: hsa:51109
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2354
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport

metaR NADPtru
name: NADP transporter, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
is described by: ECO:0000000
reversible: false

metaR r2123
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_5d0e4a63_e7fe_4eda_9a13_58357f0c21c0
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1036
name: CDO1
is: Q16878
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaR 2HBt2
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110019#
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269

metaR NDPK2n
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

metaM fmn c
is: SBO:0000247
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
name: FMN
constant: false
is: CHEBI:58210
boundary condition: false
is: C00061
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01520

metaR PUNP2
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110019#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_192cbbe2_a18b_488a_91f0_13e2373f36ab
is: P43166
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: CA7
is encoded by: hsa:766
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9274865e_3f44_4f27_ad8e_a72160da4b63
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3948
name: LDHC
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaM h m
initial concentration: 1.0
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110019#_957c6e74_99f3_440e_90b8_de4d12720294
name: ADSL
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:158
is: P30566
initial amount: NaN

metaM dmnoncoa x
name: 4,8 dimethylnonanoyl-CoA
boundary condition: false
is: HMDB11604
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1

metaR r1684
reversible: false
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR MCLACCYSR
is: SBO:0000176
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
kinetic law: MODEL1310110019#
name: 3-mercaptolactate:cysteine reductase
is described by: ECO:0000000
reversible: false
product: MODEL1310110019#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_103cb83a_e880_4fee_91e7_e1b1fd9425ee
type: Species
boundary condition: true
is: SBO:0000252
is: Q9GZV3
has only substance units: false
constant: false
initial concentration: NaN
name: SLC5A7
is encoded by: hsa:60482
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_0b7f54d4_3e61_4405_9cb2_cb48f742bba6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2686
is: A0PJJ9
name: GGT7
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaM nadph m
initial amount: NaN
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial concentration: 1.0
is: HMDB00221
type: Species
is: CHEBI:57783
is: C00005
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false

metaM cmp n
name: CMP(2-)
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:60377
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110019#_8a12466f_470e_484a_9e59_c73413aa6836
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:27124
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q15735
name: INPP5J

metaR r2355
product: MODEL1310110019#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaM pail5p hs n
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57795
boundary condition: false
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR r2126
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_9ccaf657_9dc7_4321_9e3d_7772055400f6
name: _W74642_1_c
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:W74642
type: Species
is: SBO:0000252

metaR r0942
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110019#
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reactant: MODEL1310110019#

metaM coa c
is: HMDB01423
is: CHEBI:3312
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00010
type: Species
initial amount: NaN
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false

metaR ASPDxt
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reversible: true
name: D-aspartate transport, peroxisomal
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282
is: HMDB00968
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaM pro L c
initial amount: NaN
is: HMDB00162
is: SBO:0000247
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
is: CHEBI:17203
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR CHOLPtg
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
name: choline phosphate intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110019#
is: SBO:0000185

metaM ppcoa m
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57392
name: Propanoyl-CoA
is: SBO:0000247
is: HMDB01275
is: C00100
has only substance units: false
type: Species

metaR r2125
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110019#

metaM amp m
is: HMDB00045
has only substance units: false
is: SBO:0000247
name: AMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_575dceda_f67c_485a_811b_7aafb8cd0dfc
name: PLCB2
is: SBO:0000252
constant: false
is encoded by: hsa:5330
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q59F77

metaR r2356
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110019#
fast: false
reversible: true

metaM ptth c
is: CHEBI:16753
initial amount: NaN
is: HMDB03426
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
name: pantetheine
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaM orot5p c
constant: false
has only substance units: false
boundary condition: false
name: Orotidine 5'-phosphate
is: CHEBI:57538
is: C01103
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00218

http://identifiers.org/biomodels.db/MODEL1310110019#_5f2224d3_8e42_42ae_8909_a9a512065377
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:29926
name: GMPPA
type: Species
initial concentration: NaN
is: SBO:0000252

metaM srtn c
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00259
is: CHEBI:350546
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: serotonin(1+)
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaR r0086
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110019#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110019#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
is described by: ECO:0000000

metaR HIBDm
product: MODEL1310110019#
is described by: ECO:0000269
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
modifier: MODEL1310110019#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_fc077ffe_8047_457f_8e45_0295b91e6a3d
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q99643
constant: false
name: SDHC
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6391

metaM leuktrA4 r
is: CHEBI:57463
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
is: SBO:0000247
has only substance units: false
type: Species
name: leukotriene A4(1-)
initial concentration: 1.0
constant: false

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR RE1903R
is described by: ECO:0000000
fast: false
name: RE1903
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaR r0941
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
name: Free diffusion
fast: false

metaR r0085
is described by: ECO:0000000
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110019#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
fast: false
product: MODEL1310110019#

metaR r2128
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#

metaR r2357
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true

metaR ASNt4
name: L-asparagine transport in via sodium symport
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110019#

metaM amp r
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
initial concentration: 1.0
is: C00020
is: HMDB00045
is: CHEBI:456215
name: AMP
type: Species
boundary condition: false
constant: false
has only substance units: false

metaR SERGLNNaEx
is described by: ECO:0000269
product: MODEL1310110019#
reactant: MODEL1310110019#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
fast: false

metaM HC01405 m
has only substance units: false
type: Species
is: CHEBI:28632
constant: false
name: (S)-Hydroxyoctanoyl-CoA
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
initial concentration: 1.0

metaR H2Otp
fast: false
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110019#
reversible: true
type: Reaction

metaR r0944
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110019#
name: Active transport
reversible: true
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ec03f078_a968_483e_ab2b_cdfddc01c58b
has only substance units: false
boundary condition: true
is: P78330
name: PSPH
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5723
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_66c2a40e_a25f_4530_929a_c5b4d70d8f61
has only substance units: false
constant: false
is: Q9Y6T7
is: SBO:0000252
is encoded by: hsa:1607
boundary condition: true
name: DGKB
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ac21ad87_fb5c_4bd1_86da_0d0602c99ab3
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AA278423_1_m
is encoded by: hsa:AA278423
constant: false
type: Species
has only substance units: false
boundary condition: true

metaM h r
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
name: proton
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c56e3972_ec83_4e56_a87a_69aa170f4b20
name: NDUFB7
constant: false
initial concentration: NaN
is: P17568
is encoded by: hsa:4713
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r1616
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000

metaR r1617
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110019#

metaR r2127
modifier: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_60c2a3da_b102_4414_9ae4_0d9dbf62bbdd
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q96M32
type: Species
name: AK7
is encoded by: hsa:122481

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
has only substance units: false
constant: false
is: HMDB00259
initial amount: NaN
boundary condition: false
is: CHEBI:350546
initial concentration: 1.0
is: SBO:0000247
name: serotonin(1+)

metaR r2358
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_4825b485_30cc_410b_b38a_b1417b631ee5
is: SBO:0000252
type: Species
constant: false
is: Q96IJ6
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29926
boundary condition: true
name: GMPPA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f52cde45_c742_49c3_bc36_9a8a1115082e
is: Q8TF08
name: COX7B2
constant: false
is encoded by: hsa:170712
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM sphgn c
name: sphinganine(1+)
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00269
boundary condition: false
has only substance units: false

metaR PROSTGH2t
reactant: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
fast: false
product: MODEL1310110019#
name: Prostaglandin H2 transport
kinetic law: MODEL1310110019#

metaM co2 m
boundary condition: false
is: CHEBI:16526
is: SBO:0000247
initial concentration: 1.0
is: C00011
has only substance units: false
name: CO2
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
constant: false
initial amount: NaN

metaR r1977
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00093
name: Glycerol 3-phosphate
type: Species
is: CHEBI:57597
boundary condition: false
is: SBO:0000247
is: HMDB00126
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8f941178_fb89_4898_b45b_2d542590fc3a
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9187
type: Species
is: B4DUG1
name: SLC24A1
is: SBO:0000252
constant: false
initial amount: NaN

metaM HC02206 c
initial concentration: 1.0
name: prostaglandin C1(1-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57399
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaR DHORD9
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2
product: MODEL1310110019#

metaR ALAGLYexR
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
name: L-alanine/glycine reversible exchange
product: MODEL1310110019#
reversible: true
is described by: ECO:0000304

metaM hmbil c
constant: false
is: HMDB01137
is: CHEBI:57845
type: Species
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
name: Hydroxymethylbilane
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C01024
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8d60457f_4689_4df8_8d3c_5791a92ad3e4
name: PYCR1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5831
is: A6NFM2

metaR NAt3 1
reversible: true
name: sodium proton antiporter (H:NA is 1:1)
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#

metaM HC02208 c
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:27696

metaR r2359
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM s7p c
is: SBO:0000247
has only substance units: false
constant: false
name: Sedoheptulose 7-phosphate
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
initial concentration: 1.0
initial amount: NaN
is: HMDB01068
type: Species
is: C05382
is: CHEBI:57483
boundary condition: false

metaM mev R c
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial amount: NaN
is: CHEBI:36464
boundary condition: false
constant: false
is: HMDB00227
type: Species
initial concentration: 1.0
is: SBO:0000247
name: (R)-mevalonate

metaR UMPK7n
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaM ala D e
initial concentration: 1.0
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
name: D-alanine
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0083
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_3367dbf9_7cc0_4df4_bb66_ee135512dba0
is encoded by: hsa:249
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALPL
type: Species
has only substance units: false
is: B7Z4Y6
is: SBO:0000252
constant: false

metaR r1618
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_8b890a50_9b35_4ff4_afc7_8920e780251a
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI620219
name: _AI620219_1_c
initial concentration: NaN

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
type: Species
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57795
has only substance units: false

metaM nad c
name: Nicotinamide adenine dinucleotide
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57540
is: C00003
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM chlstol r
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: CHEBI:16290
is: HMDB06842
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

metaR H2Otn
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: H2O transport, nuclear
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110019#
type: Reaction

metaM prostge2 e
initial amount: NaN
type: Species
name: prostaglandin E2(1-)
initial concentration: 1.0
is: CHEBI:606564
boundary condition: false
constant: false
has only substance units: false
is: HMDB01220
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaR r0946
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_bbf4c408_a3f9_45d4_93db_71b478afb8e2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _D87002_1_e
is encoded by: hsa:D87002
constant: false
initial concentration: NaN
type: Species

metaR LNLCt
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
name: Linoleic acid (n-C18:2) transport in via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM ethamp r
is: HMDB00224
initial concentration: 1.0
name: O-phosphonatoethanaminium(1-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190

metaR DHFtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: dihydrofolate reversible mitochondrial transport
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM ser L e
initial amount: NaN
is: CHEBI:17115
type: Species
has only substance units: false
is: HMDB00187
constant: false
name: L-serine
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
boundary condition: false

metaM CE2432 m
has only substance units: false
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaR GHMT2r
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: glycine hydroxymethyltransferase, reversible
is: SBO:0000176

metaR r0308
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
fast: false
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
reversible: false

metaR r1619
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r2129
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR PNTOte
is: SBO:0000185
fast: false
reversible: true
name: Transport of (R)-Pantothenate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000134
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#

metaM ser L c
is: HMDB00187
is: CHEBI:17115
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-serine
type: Species
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
initial concentration: 1.0

metaM HC02206 e
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin C1(1-)
boundary condition: false
is: CHEBI:57399
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaM fmn e
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
type: Species
is: CHEBI:58210
name: FMN
initial amount: NaN
is: C00061
is: HMDB01520
has only substance units: false
boundary condition: false

metaR r0081
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
product: MODEL1310110019#
reversible: true
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6643b378_d947_4155_87db_4bf32e848575
name: _U37519_1_c
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN

metaR r1612
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0157
is version of: http://identifiers.org/ec-code/6.3.4.2
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110019#
reversible: false
type: Reaction
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176

metaM methf c
is: C00445
constant: false
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
is: CHEBI:57455
boundary condition: false
name: 5,10-Methenyltetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d0c823c3_8284_4974_9da6_1db4dd491171
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9HBH5
type: Species
name: RDH14
initial amount: NaN
constant: false
is encoded by: hsa:57665

metaM amp e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:456215
type: Species
initial amount: NaN
name: AMP
constant: false
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110019#_1123a0b2_309d_4ec9_a590_c850d75f1e5f
has only substance units: false
constant: false
name: ALDH3A1
is: P30838
boundary condition: true
type: Species
is encoded by: hsa:218
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e6b4cf91_3a40_4c53_93a5_daa35aa4a731
initial amount: NaN
name: _206_1_c
is encoded by: hsa:206
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR 34HPPte
reversible: true
type: Reaction
reactant: MODEL1310110019#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is described by: ECO:0000134
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185

metaM pro L m
initial amount: NaN
is: HMDB00162
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: L-proline
is: CHEBI:17203
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0

metaM chol n
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
type: Species
is: HMDB00097
name: choline
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM 4hphac e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00020
name: 4-hydroxyphenylacetate
is: CHEBI:48999
type: Species
constant: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
initial amount: NaN
boundary condition: false
has only substance units: false

metaR RE3003M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
name: RE3003
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR r2019
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110019#
fast: false

metaM coa m
is: SBO:0000247
boundary condition: false
is: C00010
initial amount: NaN
is: CHEBI:57287
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: HMDB01423
has only substance units: false
type: Species
constant: false

metaR MAGt
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
name: monoacylglycerol 2 transport
fast: false
kinetic law: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_55bb3239_0f7a_47c1_b5d2_530f4a5bd7ef
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: SQLE
is encoded by: hsa:6713
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q5HYI4

http://identifiers.org/biomodels.db/MODEL1310110019#_659f2935_ffa7_4107_8127_b0bd4b26271b
is: Q9UBY0
initial concentration: NaN
is encoded by: hsa:6549
type: Species
constant: false
name: SLC9A2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR LTC4CP
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
fast: false
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110019#

metaR HEX4
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000304
name: hexokinase (D-mannose:ATP)
fast: false

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
name: Citrate lyase
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a1f4ceb2_9af3_49c6_ac41_b4871461e769
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6580
initial amount: NaN
has only substance units: false
name: SLC22A1
initial concentration: NaN
is: O15245
constant: false

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaM sphs1p c
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00277
boundary condition: false

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
type: Species
constant: false
boundary condition: false
is: CHEBI:16753
is: HMDB03426
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM nadph c
is: C00005
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
is: HMDB00221
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_50210438_29be_4c63_a257_5d2fe0080af7
name: _NOS2A_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NOS2A
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR PEPCKm
is described by: ECO:0000000
name: Phosphoenolpyruvate carboxykinase (GTP)
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.32

http://identifiers.org/biomodels.db/MODEL1310110019#_0a09f337_7eb0_4cbb_b4cf_f9b38ab993b0
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q6FG42
is encoded by: hsa:4701
name: NDUFA7
is: SBO:0000252

metaR r2018
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110019#
type: Reaction
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR CMPSAS
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
fast: false
name: CMP sialic acid synthase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is: SBO:0000176

metaR DNDPt9m
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
product: MODEL1310110019#
fast: false
name: dADP transport via dTDP antiport

metaM retinol cis 11 c
name: 11-cis-retinol
is: CHEBI:16302
initial concentration: 1.0
has only substance units: false
is: HMDB06216
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

metaR HEX1
type: Reaction
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000134
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
reversible: false
fast: false
name: hexokinase (D-glucose:ATP)

metaR r1614
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_df28395c_f859_4ee3_b384_5f98a41c99e3
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ND3
is: P03897
constant: false
is encoded by: hsa:4537
is: SBO:0000252
initial amount: NaN
type: Species

metaM amp c
initial amount: NaN
is: SBO:0000247
is: C00020
initial concentration: 1.0
type: Species
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2
has only substance units: false
constant: false
is: CHEBI:3322
is: HMDB00045
boundary condition: false

metaR VALt5m
product: MODEL1310110019#
fast: false
name: Valine reversible mitochondrial transport
type: Reaction
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000

metaR BTNt2
name: Biotin reversible transport via proton symport
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_f633d4be_cb62_4a8e_92a4_45ad9adcea51
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:240
boundary condition: true
type: Species
name: ALOX5
is: P09917

metaM HC01377 m
has only substance units: false
is: CHEBI:27462
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: S-(3-Methylbutanoyl)-dihydrolipoamide

http://identifiers.org/biomodels.db/MODEL1310110019#_39c45388_bf86_4b34_be7a_7d93f493089e
has only substance units: false
boundary condition: true
is encoded by: hsa:5313
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: PKLR

metaR PRFGS
product: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.5.3
type: Reaction
name: phosphoribosylformylglycinamidine synthase

http://identifiers.org/biomodels.db/MODEL1310110019#_955e18c6_91b1_4e8b_856f_966d6a47c995
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AA788780_1_c
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA788780
type: Species

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_c01f1d27_6c0d_40e0_8969_8ccb2beec543
has only substance units: false
is: B1AK53
initial amount: NaN
boundary condition: true
is encoded by: hsa:83715
constant: false
is: SBO:0000252
name: ESPN
type: Species
initial concentration: NaN

metaM 4hphac c
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
type: Species
boundary condition: false
constant: false
name: 4-hydroxyphenylacetate
is: HMDB00020
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3e3447ab_8521_4f8a_8c3b_da61d77a6374
is: O43570
is encoded by: hsa:771
initial concentration: NaN
initial amount: NaN
constant: false
name: CA12
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0bd5bff4_c41b_4875_8675_12e44006344a
is: B4E0V8
boundary condition: true
name: HAL
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3034
has only substance units: false

metaR CRNCARtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: carnitine-acetylcarnitine carrier, peroxisomal
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction

metaR HISTAtu
type: Reaction
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport

metaM glx x
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00119
constant: false
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_95583853_9600_4055_924f_da41d22e465c
name: CMA1
is: Q4FEB3
boundary condition: true
type: Species
is encoded by: hsa:1215
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR UMPK7
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
name: UMP kinase (dGTP)
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR r1615
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM tsul c
type: Species
boundary condition: false
name: thiosulfate(2-)
initial amount: NaN
is: CHEBI:16094
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c58471bb_056f_414a_8244_3212c98553b1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: PPAP2C
initial amount: NaN
is encoded by: hsa:8612
type: Species
is: E9PAY8

metaR r0660
product: MODEL1310110019#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR URAt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is described by: ECO:0000269
name: uracil transport via facilated diffusion
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110019#

metaM akg m
is: HMDB00208
name: 2-Oxoglutarate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
type: Species
is: C00026
initial amount: NaN
is: CHEBI:16810
constant: false
is: SBO:0000247

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_acedae6d_827c_4799_bea0_6ba941f97494
name: _728226_1_e
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:728226
has only substance units: false

metaR r1979
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: Y+LAT2 Utilized transport
type: Reaction

metaM 3oddcoa m
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:27868
initial concentration: 1.0
is: HMDB03937
has only substance units: false
type: Species

metaR SERGLYexR
name: L-Serine/Glycine reversible exchange
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000304
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110019#
fast: false

metaR MI34PP
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
name: inositol-3,4-bisphosphate 4-phosphatase
is: SBO:0000176
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.66
fast: false
reversible: false

metaR LCTStg
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
fast: false
type: Reaction
name: lactose transport from Golgi to extracellular (via vesicle)
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110019#

metaR HOXG
is: SBO:0000176
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000134
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Heme oxygenase 1
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.3
modifier: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ba1a75da_19fe_46c2_9105_9d4d17b3f7a2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:376497
has only substance units: false
initial concentration: NaN
name: SLC27A1
constant: false
is: Q6PCB7
type: Species
boundary condition: true

metaM 5fthf m
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: CHEBI:57457
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)
boundary condition: false

metaM pail hs n
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
type: Species
initial amount: NaN
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

http://identifiers.org/biomodels.db/MODEL1310110019#_ec6bf20b_dec9_48e2_8cd5_a7116502654e
boundary condition: true
has only substance units: false
has part: P15531
type: Species
is: SBO:0000297
is encoded by: hsa:4830
initial concentration: NaN
is encoded by: hsa:4831
constant: false
initial amount: NaN
name: NME1:NME2
has part: P22392

http://identifiers.org/biomodels.db/MODEL1310110019#_3d7f0a54_f4c7_4594_b73b_69d83e558421
name: NDUFA4
initial concentration: NaN
is encoded by: hsa:4697
has only substance units: false
is: O00483
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_21817ba5_aa92_4218_813a_f3dc1d6dcd8b
has only substance units: false
is encoded by: hsa:5092
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P61457
type: Species
name: PCBD1
boundary condition: true
constant: false

metaR CHOLD2m
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reversible: false
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269
name: choline dehydrogenase (FAD acceptor), mitochondrial
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.99.1

metaM mercplaccys c
is: HMDB06512
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

metaR GGH 10FTHF6GLUe
modifier: MODEL1310110019#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
product: MODEL1310110019#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM HC01410 m
has only substance units: false
name: (2E)-Hexenoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
constant: false
type: Species
is: CHEBI:28706

metaR UMPK5
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP)
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM g3p c
initial concentration: 1.0
initial amount: NaN
is: C00661
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
is: HMDB01112
is: http://identifiers.org/pubchem.compound/3930
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_a3b3e80c_1ebb_42ec_8d1a_d6232808f352
initial concentration: NaN
name: SLC38A5
initial amount: NaN
is: Q8WUX1
is: SBO:0000252
constant: false
is encoded by: hsa:92745
type: Species
has only substance units: false
boundary condition: true

metaM orn e
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
boundary condition: false
is: CHEBI:0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB00214
is: C01602
name: Ornithine

metaR It
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
name: Iodide uniport
reversible: true
modifier: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3d77a380_fe59_44dc_9b75_cc7d6563b4cc
is encoded by: hsa:570
has only substance units: false
boundary condition: true
name: BAAT
initial concentration: NaN
is: Q14032
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR XYLUR
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.10
modifier: MODEL1310110019#
name: xylulose reductase

http://identifiers.org/biomodels.db/MODEL1310110019#_5daa3689_6f69_4a99_b5eb_c44e34b08994
boundary condition: true
has only substance units: false
is: SBO:0000252
name: NDUFA9
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4704
initial amount: NaN
is: Q16795

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
constant: false
boundary condition: false
has only substance units: false
name: Propanoyl-CoA
is: SBO:0000247
initial amount: NaN
is: HMDB01275
is: C00100
is: CHEBI:57392
initial concentration: 1.0

metaM HC01223 m
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
initial amount: NaN
is: CHEBI:57340
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaR PSERT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.52
reversible: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
kinetic law: MODEL1310110019#
name: phosphoserine transaminase
is described by: ECO:0000269
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false

metaR r0377
modifier: MODEL1310110019#
product: MODEL1310110019#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
is: SBO:0000176

metaR PTPATe
fast: false
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: PTPATe
type: Reaction
product: MODEL1310110019#

metaR UMPK6
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110019#
name: UMP kinase (dCTP)
kinetic law: MODEL1310110019#
is described by: ECO:0000269

metaR RE1522M
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
fast: false
name: RE1522
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaM 4hpro LT m
initial amount: NaN
is: SBO:0000247
is: HMDB00725
constant: false
is: CHEBI:18095
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
name: trans-4-hydroxy-L-proline
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR GLNALANaEx
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR r2014
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110019#
is: SBO:0000185

metaR PUNP7
reversible: true
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM leuktrA4 c
name: leukotriene A4(1-)
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463

metaR r1683
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_ea2bb83c_8715_4967_bd24_c7b70732c305
is: P16152
constant: false
is encoded by: hsa:873
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: CBR1

metaM HC02180 e
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: CHEBI:28728
boundary condition: false
name: thromboxane-b2
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaR PUNP3
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
fast: false
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_975454fc_8966_414b_ba89_aa9a89d48d11
boundary condition: true
is: SBO:0000252
is encoded by: hsa:277
type: Species
name: AMY1B
has only substance units: false
constant: false
is: P04745
initial amount: NaN
initial concentration: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM dolglcp L c
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
constant: false
boundary condition: false

metaM mercplaccys e
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512

metaM h x
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
initial concentration: 1.0
name: proton
has only substance units: false
type: Species
is: C00080
is: http://identifiers.org/pubchem.compound/3380
constant: false
is: CHEBI:24636
initial amount: NaN

metaR SERALANaEx
fast: false
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
is described by: ECO:0000269

metaR r1610
type: Reaction
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000

metaM tre e
is: HMDB00975
initial concentration: 1.0
is: SBO:0000247
is: C01083
is: CHEBI:16551
type: Species
has only substance units: false
name: Trehalose
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083

metaR GUAt
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
reversible: true
name: Guanine transport
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
fast: false

metaM orn c
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:0
type: Species
is: SBO:0000247
constant: false
name: Ornithine

metaR UMPK3
reversible: true
type: Reaction
name: UMP kinase (UTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000269

metaR OCDCEAtr
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110019#

metaR r2017
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#

metaM retinal cis 9 c
name: all-trans-retinal
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01358
has only substance units: false
type: Species
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial concentration: 1.0

metaR PUNP4
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
name: purine-nucleoside phosphorylase (Deoxyguanosine)
fast: false
is described by: ECO:0000269
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM co2 r
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
constant: false
is: SBO:0000247
has only substance units: false
name: CO2
is: CHEBI:16526
initial amount: NaN
type: Species
is: HMDB01967
boundary condition: false

metaM dcyt e
has only substance units: false
is: C00881
constant: false
initial amount: NaN
is: HMDB00014
type: Species
boundary condition: false
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: SBO:0000247
name: Deoxycytidine

http://identifiers.org/biomodels.db/MODEL1310110019#_5c9ebc22_be6f_44af_8897_311ee6746172
boundary condition: true
name: HADHA
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3030
is: E9KL44
has only substance units: false
type: Species

metaM btcoa m
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00136
constant: false
name: Butanoyl-CoA
type: Species
is: CHEBI:57371
initial amount: NaN
is: HMDB01088

metaR RE0830C
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
is: SBO:0000176
name: RE0830
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_df93e89c_b31a_4eff_8fe5_17dedb6a1bbd
type: Species
boundary condition: true
is: O95498
initial concentration: NaN
constant: false
is encoded by: hsa:8875
name: VNN2
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_459794f4_4f4f_465a_b2b7_b3bdf5d2a6dd
is: Q9NNW7
constant: false
name: TXNRD2
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10587
boundary condition: true
type: Species
initial concentration: NaN

metaM pacald c
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
name: phenylacetaldehyde
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06236
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16424
constant: false

metaM sphs1p e
has only substance units: false
initial amount: NaN
type: Species
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
is: HMDB00277
is: SBO:0000247
is: CHEBI:60119
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false

metaR r1611
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110019#

metaM 3hmbcoa m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01356
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
has only substance units: false
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
is: CHEBI:57312

metaM pmtcoa m
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
is: HMDB01338
initial concentration: 1.0
constant: false
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species

metaR UMPK4
name: UMP kinase (GTP)
product: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_a0ce4056_d6e9_45fa_a3dc_8171930eb533
is encoded by: hsa:57665
name: RDH14
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9HBH5

metaM leuktrA4 e
boundary condition: false
initial amount: NaN
name: leukotriene A4(1-)
type: Species
is: SBO:0000247
is: HMDB01337
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM HC02180 c
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28728
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_67ade6f5_3b2b_45fb_a2eb_704fd7f60fee
is: O15254
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACOX3
is encoded by: hsa:8310
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaM ocdca c
is: HMDB00827
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: stearate
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_695945e1_6a3e_47db_8fd0_622147baa4d8
is encoded by: hsa:AI090874
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: _AI090874_1_c
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_0d37cab1_a018_4590_9e97_bcccc1a6360b
initial amount: NaN
is: Q96NR8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:145226
type: Species
constant: false
name: RDH12
is: SBO:0000252
has only substance units: false

metaR r0517
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: true

metaM ocdca e
is: CHEBI:25629
is: C01530
initial amount: NaN
is: HMDB00827
boundary condition: false
is: SBO:0000247
name: octadecanoate (n-C18:0)
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
constant: false

metaM tdchola e
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
name: taurochenodeoxycholate
is: CHEBI:9407
boundary condition: false
constant: false
has only substance units: false
is: HMDB00951
type: Species
initial amount: NaN

metaR RADH2
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
name: retinal dehydrogenase (NADPH)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110019#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_92430d68_f700_4a22_8af0_76614ed95996
boundary condition: true
initial concentration: NaN
is: Q6IBB5
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFA1
constant: false
is encoded by: hsa:4694

metaR UMPK2
name: UMP kinase (CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_28d76822_a80f_424f_a509_a99ae8047852
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5319
type: Species
constant: false
has only substance units: false
is: P04054
name: PLA2G1B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_20fea6df_4562_4a49_a286_605d05862a38
has only substance units: false
initial amount: NaN
constant: false
name: _AI469183_1_x
boundary condition: true
is encoded by: hsa:AI469183
is: SBO:0000252
initial concentration: NaN
type: Species

metaR DGK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
fast: false
product: MODEL1310110019#
is described by: ECO:0000000

metaM 34dhoxpeg c
has only substance units: false
name: 3,4-Dihydroxyphenylethyleneglycol
is: http://identifiers.org/pubchem.compound/7902
constant: false
is: HMDB00318
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial amount: NaN
type: Species
is: SBO:0000247
is: C05576

metaR CDIPTr
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.8.11
name: phosphatidylinositol synthase (Homo sapiens)

metaR CYTK1
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (CMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_708a5692_bf28_429e_b1b0_857ca6264927
is encoded by: hsa:80270
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: HSD3B7
is: Q9H2F3
is: SBO:0000252

metaM mmcoa R m
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
constant: false
name: (R)-methylmalonyl-CoA(5-)
is: HMDB01269
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57326

metaM inost e
has only substance units: false
boundary condition: false
is: CHEBI:17268
is: SBO:0000247
initial amount: NaN
name: myo-inositol
initial concentration: 1.0
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0a946442_d1c6_4b11_849b_cb757c98419e
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: _NM_013421_1_m
initial amount: NaN
has only substance units: false
is encoded by: hsa:NM 013421

metaR SPH1Pte
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
kinetic law: MODEL1310110019#
fast: false
name: sph1p transport
is described by: ECO:0000000

metaM h2o r
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
constant: false
has only substance units: false
is: HMDB02111
initial amount: NaN
is: SBO:0000247
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110019#_03ce3ea5_63b6_42f6_8cd3_1531b2f589fd
initial amount: NaN
name: SLCO4A1
boundary condition: true
is encoded by: hsa:28231
type: Species
initial concentration: NaN
constant: false
is: Q96BD0
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0cd358e1_c258_40ff_91c6_b38303e316fc
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B7Z792
is: SBO:0000252
name: NDUFS2
constant: false
is encoded by: hsa:4720
type: Species
initial amount: NaN

metaR HISCAT1
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_9285da1e_b9f7_48a3_b26d_ba7772454d2b
name: SUOX
initial concentration: NaN
is: P51687
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6821

metaM dd2coa m
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB03712
is: SBO:0000247
initial concentration: 1.0

metaR KHte
is described by: ECO:0000134
type: Reaction
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110019#
fast: false
name: KHte

metaR r1450
reactant: MODEL1310110019#
name: EC:1.3.3.6
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaM dha e
initial amount: NaN
has only substance units: false
is: CHEBI:16016
is: HMDB01882
initial concentration: 1.0
constant: false
name: glycerone
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184

http://identifiers.org/biomodels.db/MODEL1310110019#_7a80a7f4_6b31_49f1_9239_d44229e95868
has only substance units: false
is: Q9UHV8
is encoded by: hsa:29124
name: LGALS13
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_8573883c_a07e_4261_886c_3202a9f97155
initial amount: NaN
boundary condition: true
is: Q9BZV2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80704
name: SLC19A3
has only substance units: false
constant: false
type: Species

metaM gtp c
initial concentration: 1.0
boundary condition: false
name: GTP
initial amount: NaN
is: CHEBI:37565
has only substance units: false
is: HMDB01273
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
type: Species
is: C00044

metaR PSFLIPm
kinetic law: MODEL1310110019#
reversible: false
name: phosphatidylserine flippase
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_23c7cad8_568d_4606_bf06_aab98a184045
initial amount: NaN
boundary condition: true
name: NDUFA3
is encoded by: hsa:4696
is: O95167
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_9b8f43a6_33ce_4426_970a_fc1a4a2380b4
is encoded by: hsa:2629
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: GBA
has only substance units: false
is: SBO:0000252
constant: false

metaM chol e
has only substance units: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: C00114
type: Species
is: HMDB00097
boundary condition: false
is: SBO:0000247
name: Choline
constant: false
initial amount: NaN

metaR LEUKTRD4tr
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: leukotriene intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110019#

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
name: taurochenodeoxycholate
is: SBO:0000247
is: CHEBI:9407
has only substance units: false
boundary condition: false
constant: false
is: HMDB00951
type: Species
initial concentration: 1.0

metaM mi145p c
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:203600
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial amount: NaN
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
constant: false
initial concentration: 1.0
is: HMDB01498
has only substance units: false

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f3082805_f68f_4e27_b208_4c6b7ecf795e
initial amount: NaN
is encoded by: hsa:8277
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: TKTL1
is: B7Z7I0

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM utp c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00285
has only substance units: false
is: CHEBI:46398
constant: false
initial amount: NaN
is: C00075
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP
type: Species

metaM coa r
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
name: Coenzyme A
is: C00010
type: Species
is: HMDB01423
is: CHEBI:57287
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaR r1453
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110019#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8

http://identifiers.org/biomodels.db/MODEL1310110019#_081e21c1_2c4b_4b5d_907a_c407185c999e
name: LDHD
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:197257
boundary condition: true
has only substance units: false

metaR PHEMEt
product: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
type: Reaction
reversible: false
name: heme transport
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is described by: ECO:0000269

metaM pmtcoa r
is: C00154
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110019#_043d198b_7d86_4b4d_bb93_8a35e60170cb
constant: false
type: Species
initial concentration: NaN
name: NOS1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4842
has only substance units: false
is: B4DG68

metaR r0668
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43

metaM 34dhoxpeg e
is: HMDB00318
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
type: Species
is: http://identifiers.org/pubchem.compound/7902
is: C05576
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 3,4-Dihydroxyphenylethyleneglycol
constant: false

metaR r0160
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reactant: MODEL1310110019#
type: Reaction

metaR DCTPtn
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#
name: dCTP diffusion in nucleus
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_c2f5d0a1_98d7_4bfb_9658_ac7c25951c02
constant: false
name: ADSSL1
is: B3KTV4
is encoded by: hsa:122622
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_3810ab58_52e6_4cfd_ae77_e67bdb771d57
is encoded by: hsa:57282
has only substance units: false
is: B7Z1R0
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC4A10
type: Species

metaR CYTK3
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: true
name: cytidylate kinase (CMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b7d116e7_cb47_410d_a7b2_557c791360b6
is: SBO:0000252
is: O75715
is encoded by: hsa:2880
constant: false
has only substance units: false
name: GPX5
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR TREHe
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
is described by: ECO:0000269
is: SBO:0000176
name: alpha,alpha-trehalase
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
reversible: false
product: MODEL1310110019#

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR GLCtg
fast: false
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000269
name: glucose transport, Golgi apparatus
type: Reaction
modifier: MODEL1310110019#
reversible: true

metaR ADK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
is: SBO:0000176
name: adentylate kinase (GTP)
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: true
modifier: MODEL1310110019#
product: MODEL1310110019#

metaM glyc3p c
is: HMDB00126
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57597
name: Glycerol 3-phosphate
constant: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: C00093

http://identifiers.org/biomodels.db/MODEL1310110019#_6b975fd8_7dd6_43f2_8639_c0c42e7cb199
initial concentration: NaN
is: Q7L2M7
is encoded by: hsa:5211
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: PFKL
is: SBO:0000252

metaM HC01842 c
boundary condition: false
is: SBO:0000247
is: CHEBI:31997
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: Phosphodimethylethanolamine
initial amount: NaN

metaM lys L m
boundary condition: false
name: L-lysinium(1+)
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00182
initial amount: NaN
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_f2eedaa3_e11f_432a_8c16_f44f14f43ecd
name: PYCRL
is encoded by: hsa:65263
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q53H96

metaM datp c
constant: false
is: C00131
is: HMDB01532
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
type: Species
is: CHEBI:61404
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM his L e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15971
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
type: Species
boundary condition: false
constant: false
is: HMDB00177

metaR r0456
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
modifier: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaR r0669
product: MODEL1310110019#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110019#

metaR CYTK2
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110019#
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_aeba4c20_778b_4971_81ae_d16156285398
is: SBO:0000297
initial concentration: NaN
has part: Q86YI5
has part: P11177
name: DLAT:DLD:PDHA2:PDHB:PDHX
is encoded by: hsa:5162
type: Species
boundary condition: true
has part: P29803
is encoded by: hsa:1737
has only substance units: false
is encoded by: hsa:5161
initial amount: NaN
constant: false

metaR Htg
name: proton diffusion (Golgi)
product: MODEL1310110019#
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_6bd068b0_5138_4f77_86b9_55f94eef0487
constant: false
is: SBO:0000252
name: _AI480132_1_c
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI480132
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_2d040707_cecc_4665_906b_62f3e392a925
is encoded by: hsa:23475
name: QPRT
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q15274
constant: false

metaR PGDI
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.3.99.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: true
type: Reaction
fast: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
initial concentration: 1.0
name: dCDP(3-)
has only substance units: false
constant: false
is: HMDB01245
boundary condition: false
is: CHEBI:58593
type: Species
initial amount: NaN

metaM pail4p hs c
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
type: Species
has only substance units: false

metaM gua c
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16235
has only substance units: false
is: HMDB00132
is: SBO:0000247
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
name: Guanine
is: C00242

http://identifiers.org/biomodels.db/MODEL1310110019#_2b13b6f9_3bd2_47f3_82dd_093baeacfa4e
is encoded by: hsa:6241
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P31350
name: RRM2
type: Species
has only substance units: false

metaR PI45PLC
product: MODEL1310110019#
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_bef85e6c_1325_4881_b044_62e2e9642d58
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AA629629_1_m
is: SBO:0000252
is encoded by: hsa:AA629629
initial amount: NaN
type: Species

metaR NRPPHRtu
fast: false
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
type: Reaction
name: Norepinephrine uniport

metaM 7dhf e
is: HMDB06559
is: SBO:0000247
name: heptaglutamyl folate (DHF)
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR CYTK5
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: true
reactant: MODEL1310110019#

metaR r0666
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reversible: true
fast: false
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#

metaR r0730
is: SBO:0000176
kinetic law: MODEL1310110019#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
modifier: MODEL1310110019#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR NADPHtru
product: MODEL1310110019#
is: SBO:0000185
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_7145dc97_d6ef_4b73_80a5_be83ca4455a2
is: SBO:0000252
constant: false
boundary condition: true
name: GCK
is: P35557
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110019#_2e8b05f9_bd77_468c_b406_839c8b1c8ccb
initial concentration: NaN
constant: false
is: B7Z6Q4
has only substance units: false
initial amount: NaN
type: Species
name: IMPA1
is: SBO:0000252
is encoded by: hsa:3612
boundary condition: true

metaR NADtx
name: transport of NAD into peroxisome
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#

metaR KCC2t
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110019#
name: K+-Cl- cotransporter (NH4+)
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185

metaR NDP7g
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
fast: false
kinetic law: MODEL1310110019#

metaM dcdp n
initial concentration: 1.0
is: HMDB01245
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
name: dCDP(3-)
constant: false
is: CHEBI:58593
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e62547d4_348c_4229_9a04_40f745d73156
boundary condition: true
type: Species
initial concentration: NaN
is: Q7Z725
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6569
name: SLC34A1
initial amount: NaN

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM prostgh2 e
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: prostaglandin H2(1-)
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01381
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

http://identifiers.org/biomodels.db/MODEL1310110019#_126259d4_bdc1_4c9a_adef_f6716ff17b4f
boundary condition: true
has only substance units: false
is: P46721
name: SLCO1A2
is encoded by: hsa:6579
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR CYTK4
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (dCMP)(GTP)
reversible: true
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM atp r
constant: false
is: C00002
type: Species
boundary condition: false
has only substance units: false
is: HMDB00538
name: ATP(4-)
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247

metaR r0450
kinetic law: MODEL1310110019#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
is described by: ECO:0000000

metaR CO2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: CO2 endoplasmic reticular transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM coa n
has only substance units: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
name: coenzyme A(4-)
initial concentration: 1.0
constant: false
is: HMDB01423
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR RADH4
fast: false
product: MODEL1310110019#
is: SBO:0000176
name: retinal dehydrogenase (NADPH)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000

metaM HC02207 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
is: CHEBI:27555
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaM chol m
is: CHEBI:15354
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
initial concentration: 1.0
is: HMDB00097
name: choline
boundary condition: false

metaM gua e
is: CHEBI:16235
is: HMDB00132
initial concentration: 1.0
is: SBO:0000247
type: Species
name: guanine
has only substance units: false
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7b299699_bc42_448a_8034_d05d604b1317
boundary condition: true
constant: false
is: P13995
is encoded by: hsa:10797
initial concentration: NaN
is: SBO:0000252
name: MTHFD2
has only substance units: false
type: Species
initial amount: NaN

metaR MMCDm
reversible: false
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.9
fast: false
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
kinetic law: MODEL1310110019#
is described by: ECO:0000212
name: Methylmalonyl-CoA decarboxylase, mitochondrial

metaR CYTK7
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR r0732
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110019#

metaM inost c
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17268
initial concentration: 1.0
initial amount: NaN
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
has only substance units: false
is: HMDB00211

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_7f6695fe_37e7_403e_928b_0ae8637dd6ce
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1345
has only substance units: false
initial amount: NaN
type: Species
is: P09669
is: SBO:0000252
constant: false
name: COX6C

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR VALTA
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_f583e4f3_55b9_4f98_93e4_01bdcb8c34e0
is encoded by: hsa:343
is: O94778
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: AQP8
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_1f365404_c285_4610_9728_0c59a86ddecb
boundary condition: true
is: SBO:0000252
type: Species
name: SLC6A3
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6531
initial amount: NaN
is: Q01959

metaM h2o x
constant: false
name: H2O
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02111
boundary condition: false
is: C00001
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: CHEBI:15377

metaR CYTK6
modifier: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
fast: false
name: cytidylate kinase (CMP,CTP)
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0731
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_4df7fb34_1575_4631_9337_743e73d67633
has only substance units: false
constant: false
is encoded by: hsa:8527
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q16760
boundary condition: true
initial amount: NaN
name: DGKD

metaR GLYt7 211 r
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM so4 m
name: sulfate
is: HMDB01448
is: CHEBI:16189
is: SBO:0000247
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_e4b1ee4d_021c_4a7d_907d_5d09b370bcab
constant: false
initial concentration: NaN
is encoded by: hsa:AI656480
name: _AI656480_1_m
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_12bcfee6_a960_42ac_b2ee_881925639976
name: SLC28A2
initial concentration: NaN
is encoded by: hsa:9153
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: O43868
has only substance units: false
is: SBO:0000252

metaR r1538
is described by: ECO:0000000
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_277a9bc8_1355_4dbe_aac5_11aee1ed92bd
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P22392
is encoded by: hsa:4831
constant: false
initial amount: NaN
name: NME2

http://identifiers.org/biomodels.db/MODEL1310110019#_31589217_3a45_45c6_b3f3_c62a6ce14c16
is: P27707
has only substance units: false
boundary condition: true
is encoded by: hsa:1633
name: DCK
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaR GLNCYSNaEx
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#

metaM pmtcoa x
type: Species
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
is: HMDB01338
initial amount: NaN
is: CHEBI:57379
initial concentration: 1.0
boundary condition: false
is: C00154
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaR O2ter
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
name: O2 transport, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a52849d0_74cd_4462_965e_035f86fadd2a
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q53YB7
constant: false
type: Species
initial amount: NaN
name: COX5B
is encoded by: hsa:1329
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_81a0391e_0325_4370_9e58_37ab2ced7be9
is: SBO:0000252
is: Q03393
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5805
constant: false
initial amount: NaN
name: PTS

http://identifiers.org/biomodels.db/MODEL1310110019#_a27eb14e_6b55_4aee_8218_1b1a261fb233
constant: false
name: _AA502753_1_m
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AA502753

metaR r0734
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR CYTK9
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_df3eb1d5_02c1_4527_ab8b_0d3587c76bf7
is: SBO:0000252
constant: false
is encoded by: hsa:8883
name: NAE1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: A8MU28

metaR r1459
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaR CHOLATEt
reversible: true
name: cholate transport via bicarbonate countertransport
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110019#
type: Reaction

metaM pail3p hs n
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
has only substance units: false
is: CHEBI:58088
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR DHPR2
is described by: ECO:0000304
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: 6,7-dihydropteridine reduction
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110019#

metaM leuktrD4 c
boundary condition: false
has only substance units: false
initial amount: NaN
name: Leukotriene D4
is: HMDB03080
is: CHEBI:28666
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247

metaM duri e
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: HMDB00012
name: Deoxyuridine
is: CHEBI:16450
boundary condition: false

metaR r0733
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
reactant: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
is: SBO:0000247
is: CHEBI:58178
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR MERCPLACCYSt
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
fast: false
product: MODEL1310110019#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
type: Reaction

metaR CYTK8
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110019#
type: Reaction
fast: false
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_2a0c00d6_9c65_481d_aa7d_42393996fc25
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:594
is: P21953
initial amount: NaN
name: BCKDHB

metaR NAIt
modifier: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_644781bc_1473_4ffd_b84c_43c233b1504f
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2819
type: Species
is: F8W1L5
name: GPD1

metaM dolglcp L r
type: Species
is: SBO:0000247
is: CHEBI:15812
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_97128203_12dc_48b2_8ff8_23f48a61ad40
boundary condition: true
name: GMPR2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:51292
constant: false
is: Q86T14

metaM ocdcea e
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
constant: false
is: CHEBI:0
name: octadecenoate (n-C18:1)
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00207

metaM h e
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: C00080
boundary condition: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: proton
is: CHEBI:24636

metaR r0936
fast: false
kinetic law: MODEL1310110019#
name: Transport reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_5e953cad_9e4f_42e4_bce1_70b64615c2a0
boundary condition: true
is encoded by: hsa:122970
constant: false
is: Q8N9L9
initial amount: NaN
type: Species
has only substance units: false
name: ACOT4
initial concentration: NaN
is: SBO:0000252

metaR UMPK6n
name: UMP kinase (dCTP),nuclear
is: SBO:0000176
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110019#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_f837989a_ff98_43ca_810d_89e43f1f5074
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: FLAD1
initial amount: NaN
is: Q8NFF5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80308

metaM r1p c
is: CHEBI:57720
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: HMDB01489
boundary condition: false
is: C00442
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0

metaM datp m
boundary condition: false
type: Species
is: C00131
is: SBO:0000247
is: CHEBI:61404
has only substance units: false
name: dATP
constant: false
is: HMDB01532
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_c66429a4_008e_496d_be9d_32f38d8f2c9c
is encoded by: hsa:53354
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: PANK1
is: SBO:0000252
type: Species
initial concentration: NaN

metaM mercppyr c
initial concentration: 1.0
boundary condition: false
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
initial amount: NaN
is: CHEBI:57678
is: HMDB01368
type: Species
constant: false
has only substance units: false
is: SBO:0000247

metaM HC01434 m
boundary condition: false
is: SBO:0000247
is: CHEBI:58931
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: oxalatosuccinate(3-)
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

http://identifiers.org/biomodels.db/MODEL1310110019#_97e45c9d_3960_4f16_9b40_db678a60cc97
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2348
constant: false
name: FOLR1
initial amount: NaN

metaR r2506
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
name: Utilized transport
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8b42c1a2_ef71_4b16_b1e6_71141e377442
type: Species
is: SBO:0000252
name: _AI934540_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI934540

http://identifiers.org/biomodels.db/MODEL1310110019#_17c10cca_acf3_4f93_abd3_67db5421a47c
name: PLCB1
is encoded by: hsa:23236
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ad30183d_8771_4414_b81f_5dfe318b5c38
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:80025
has only substance units: false
is: Q6P1K9
initial amount: NaN
name: PANK2
boundary condition: true
type: Species

metaR r0937
product: MODEL1310110019#
name: Transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction
is described by: ECO:0000000

metaR r2360
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport

metaM lac D c
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01311
initial concentration: 1.0
name: (R)-lactate
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
boundary condition: false
initial amount: NaN

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: Transport of 4-methyl-2-oxopentanoate
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_1fbbc202_eb7f_421e_a90b_41ccb61cfbf8
boundary condition: true
name: ITPKC
is encoded by: hsa:80271
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q96DU7

metaM 7dhchsterol c
has only substance units: false
is: CHEBI:17759
constant: false
name: cholesta-5,7-dien-3beta-ol
type: Species
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00032

metaM h2o m
has only substance units: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: SBO:0000247
is: HMDB02111
is: CHEBI:15377
name: H2O
is: C00001
type: Species
constant: false
initial concentration: 1.0

metaR GGH 6THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
reversible: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
reactant: MODEL1310110019#

metaR RE3524R
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: RE3524
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_ddde26ac_318d_4613_9fc7_e75d383b49ca
is encoded by: hsa:4702
initial concentration: NaN
name: NDUFA8
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: B1AM93

http://identifiers.org/biomodels.db/MODEL1310110019#_a9a454ba_01b7_4092_b2e1_35ab5b2aaa2b
initial concentration: NaN
constant: false
has only substance units: false
is: Q96I99
is encoded by: hsa:8801
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SUCLG2
type: Species

metaM duri c
initial concentration: 1.0
is: C00526
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: Deoxyuridine
is: HMDB00012
boundary condition: false
has only substance units: false
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaR r0735
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
product: MODEL1310110019#
modifier: MODEL1310110019#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
reactant: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM leuktrD4 e
boundary condition: false
is: HMDB03080
is: CHEBI:28666
has only substance units: false
name: Leukotriene D4
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN

metaM sql r
initial amount: NaN
name: squalene
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
is: HMDB00256
type: Species
is: CHEBI:15440
initial concentration: 1.0
has only substance units: false
constant: false

metaR r2130
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: true
kinetic law: MODEL1310110019#

metaM h c
constant: false
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
is: C00080
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c390f256_343d_43de_8161_df8849f1bf3c
is encoded by: hsa:1891
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q13011
constant: false
boundary condition: true
name: ECH1

metaM ocdcea c
boundary condition: false
has only substance units: false
type: Species
is: C00712
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
is: SBO:0000247
name: octadecenoate (n-C18:1)
initial amount: NaN
constant: false

metaM lys L e
is: CHEBI:32551
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
constant: false
has only substance units: false
is: HMDB00182
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110019#_afd246e1_bf6a_4d40_913f_07228fabeb1a
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:38
name: ACAT1
initial amount: NaN
is: P24752

metaM C04849 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
is: CHEBI:57449
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_8537bdda_6ef4_4230_b522_4fda2bef75e3
name: LEFTY1
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: O75610
initial amount: NaN
is encoded by: hsa:10637
constant: false

metaM udpglcur r
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
constant: false
is: CHEBI:58052
is: HMDB00935
is: C00167

http://identifiers.org/biomodels.db/MODEL1310110019#_d7d79d86_1e16_423c_8cab_57f4c2edac1d
is: SBO:0000297
initial concentration: NaN
type: Species
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
is encoded by: hsa:4967
has part: B4E3E9
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_83ec1ce9_f4f2_4669_83db_d793da920f28
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9583
constant: false
is: Q9Y227
is: SBO:0000252
has only substance units: false
name: ENTPD4
boundary condition: true
type: Species

metaR RE2677E
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
name: RE2677

http://identifiers.org/biomodels.db/MODEL1310110019#_c770b999_ed9c_4d51_8f11_a2278eb3bb7b
initial concentration: NaN
boundary condition: true
name: UPP1
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:7378
initial amount: NaN

metaR r2508
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true

metaM glx c
initial concentration: 1.0
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
is: HMDB00119
is: SBO:0000247
is: CHEBI:36655
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_eb7ab91a_f538_468e_ad86_fda17ebbd561
is: O95470
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SGPL1
is encoded by: hsa:8879
type: Species
boundary condition: true
constant: false

metaR IPDDIx
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.2
name: isopentenyl-diphosphate D-isomerase
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ

metaR HSD3B7P
is: SBO:0000176
product: MODEL1310110019#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
type: Reaction
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reversible: false

metaR r0224
fast: false
reversible: false
product: MODEL1310110019#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction

metaM pchol hs c
name: Phosphatidylcholine
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16110
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247

metaM utp e
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: UTP(4-)
is: HMDB00285
initial amount: NaN

metaM coa x
initial concentration: 1.0
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
is: SBO:0000247
name: Coenzyme A
is: CHEBI:57287
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: C00010

metaM lac D e
is: SBO:0000247
boundary condition: false
is: HMDB01311
has only substance units: false
type: Species
initial concentration: 1.0
name: (R)-lactate
initial amount: NaN
is: CHEBI:16004
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false

metaR r2362
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
reversible: true
fast: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_87ef868e_18d1_4333_8245_032cd0e0e8b7
type: Species
has only substance units: false
initial amount: NaN
name: PLA2G4A
is: SBO:0000252
is: P47712
is encoded by: hsa:5321
initial concentration: NaN
constant: false
boundary condition: true

metaM etha c
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: HMDB00149
is: SBO:0000247
type: Species
is: CHEBI:57603
name: etha[c]
boundary condition: false
initial amount: NaN

metaR r2131
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#

metaR SERGLNexR
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
reversible: true
is: SBO:0000185
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000304

metaM CE2431 m
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
type: Species
is: CHEBI:57795
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0
has only substance units: false

metaM his L c
initial concentration: 1.0
is: HMDB00177
constant: false
type: Species
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
has only substance units: false
is: CHEBI:15971
initial amount: NaN
boundary condition: false

metaR RE3567C
fast: false
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
name: RE3567
product: MODEL1310110019#
reversible: true

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR ADK1
is: SBO:0000176
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110019#
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM h2o n
constant: false
name: water
is: CHEBI:15377
is: HMDB02111
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM lys L c
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00182
constant: false
name: L-lysinium(1+)

metaR CYSTHRNaEx
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110019#
fast: false
is: SBO:0000185
modifier: MODEL1310110019#
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)

metaR r2361
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r2132
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110019#
name: Utilized transport
fast: false
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000

metaM cl c
initial concentration: 1.0
has only substance units: false
is: C00115
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
name: Chloride
is: CHEBI:3966
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r0885
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaR r0226
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

metaM pchol hs e
initial amount: NaN
name: Phosphatidylcholine
has only substance units: false
type: Species
is: CHEBI:16110
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110019#_a40ddd63_d778_4f50_b5fb_58a31866c507
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10637
has only substance units: false
initial amount: NaN
name: LEFTY1
type: Species
is: O75610
boundary condition: true

metaR GLUTCOADHm
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110019#
is described by: ECO:0000304
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d80acf3b_7187_40da_92c3_2252fb97f42d
constant: false
is encoded by: hsa:5230
initial concentration: NaN
is: P00558
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PGK1

metaM amp x
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: AMP
is: C00020
type: Species
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: CHEBI:456215

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM HC01162 c
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: SBO:0000247
has only substance units: false
is: CHEBI:58376

metaR r2364
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110019#

metaM atp x
initial concentration: 1.0
is: CHEBI:57299
constant: false
is: HMDB00538
is: C00002
name: ATP(4-)
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01084
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_5c680284_8d4a_4a9e_93ab_0829c2bcbf44
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM 2mpdhl m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
constant: false

metaR r2133
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false

metaM gtp m
has only substance units: false
constant: false
type: Species
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
initial amount: NaN
boundary condition: false
name: GTP
is: HMDB01273
is: SBO:0000247
initial concentration: 1.0

metaR r0512
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000176
fast: false
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110019#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_2aa69dd3_9dfc_41ec_89db_b3e69b9a7794
boundary condition: true
initial concentration: NaN
type: Species
is: P05062
is encoded by: hsa:229
has only substance units: false
name: ALDOB
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_45f2e05a_a8ab_4e05_a248_a9bbbe76d43d
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI935189_1_m
is encoded by: hsa:AI935189
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_9122e796_c4de_43be_9906_77c793fd63df
is: SBO:0000252
boundary condition: true
is: Q01968
type: Species
name: OCRL
is encoded by: hsa:4952
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM chol c
is: C00114
boundary condition: false
is: CHEBI:15354
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
is: HMDB00097
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaR CYTK4n
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
name: cytidylate kinase (dCMP,GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_98810d76_abf0_4f98_b03b_0f3863097a43
is encoded by: hsa:51181
initial concentration: NaN
initial amount: NaN
is: Q7Z4W1
has only substance units: false
type: Species
boundary condition: true
name: DCXR
constant: false
is: SBO:0000252

metaR CBR2
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
is version of: http://identifiers.org/ec-code/1.1.1.189
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110019#
fast: false
name: Carbonyl reductase [NADPH] 1
product: MODEL1310110019#

metaM fprica c
constant: false
is: CHEBI:58467
is: C04734
initial concentration: 1.0
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01439
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_109d0625_8cab_4bc3_aa6a_e11a35720f21
is encoded by: hsa:4056
initial amount: NaN
constant: false
name: LTC4S
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_23f0757e_d878_49e4_a338_78dfea2916c3
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CPOX
type: Species
is encoded by: hsa:1371
initial concentration: NaN
has only substance units: false
is: P36551

metaM h g
constant: false
is: CHEBI:24636
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
initial concentration: 1.0
name: proton

metaR r2363
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185

metaM so4 e
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16189
type: Species
name: sulfate
boundary condition: false
is: HMDB01448
has only substance units: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaM gtp n
constant: false
type: Species
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
initial concentration: 1.0
is: CHEBI:37565
is: HMDB01273
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_b18ec891_10f9_4378_9d04_98ef5c89bba6
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: HPGDS
has only substance units: false
is encoded by: hsa:27306
is: O60760

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110019#
type: Reaction
fast: false
reactant: MODEL1310110019#

metaM dtdp c
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
name: dTDP
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58369
is: SBO:0000247
is: HMDB01274
boundary condition: false
is: C00363

http://identifiers.org/biomodels.db/MODEL1310110019#_da15a555_b845_4382_b064_e389d31a88a3
is: B2RDZ2
type: Species
name: RFK
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55312
has only substance units: false
constant: false

metaM ppa e
has only substance units: false
is: CHEBI:17272
is: HMDB00237
type: Species
constant: false
boundary condition: false
name: propionate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

http://identifiers.org/biomodels.db/MODEL1310110019#_88f121a9_d3b2_4257_bd4e_49a1910e0c68
constant: false
name: DDC
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q53Y41
has only substance units: false
is encoded by: hsa:1644
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_b72c3e9d_bf06_4d07_953c_f19dcb855e02
type: Species
constant: false
is encoded by: hsa:226
boundary condition: true
name: ALDOA
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM phe L c
is: CHEBI:17295
boundary condition: false
constant: false
has only substance units: false
is: HMDB00159
type: Species
is: SBO:0000247
name: L-phenylalanine
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_8dc374f7_a7b3_4a06_8af0_e5678b0f0f65
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM lac L c
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
name: (S)-lactate
is: HMDB00190
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16651
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_22abe562_2ed5_4e8d_8032_2f76886f245c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFB10
is: A8K761
is encoded by: hsa:4716

metaR r2114
modifier: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaM HC01104 e
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:61146
name: 4-nitrophenyl phosphate(2-)
initial concentration: 1.0
boundary condition: false

metaM leu L m
constant: false
is: CHEBI:15603
boundary condition: false
is: HMDB00687
type: Species
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_71822869_c7b7_4f22_b438_571445161d0d
type: Species
name: _AI601100_1_m
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI601100
constant: false

metaR GluForTx
modifier: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
name: Glutamate formimidoyltransferase
product: MODEL1310110019#
reversible: false
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.5

metaR r2367
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110019#_3a30d6d9_662c_4c1f_83ad_9c75357d1d5a
is: SBO:0000252
is: P11310
type: Species
initial concentration: NaN
is encoded by: hsa:34
name: ACADM
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM h2o c
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: H2O CHARGE: 0
has only substance units: false
is: C00001
is: SBO:0000247
is: HMDB02111
initial amount: NaN
boundary condition: false
name: H2O
is: CHEBI:3303

metaM prostgi2 c
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01335
name: prostaglandin I2(1-)
type: Species
is: CHEBI:57403

metaR r1984
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
boundary condition: false
name: dCDP
is: C00705
is: CHEBI:58593
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR URIK1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
product: MODEL1310110019#
name: uridine kinase (ATP:Uridine)
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_86e4a28a_aa3d_4ba2_859e_f231ca65a610
boundary condition: true
type: Species
has only substance units: false
name: TMEM91
is: C9JZ62
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:641649
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_7343b59c_9e51_4629_b367_a109ff4f74e8
is: O43772
initial concentration: NaN
constant: false
is encoded by: hsa:788
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: SLC25A20

http://identifiers.org/biomodels.db/MODEL1310110019#_ccbdf829_0c99_4490_92ee_63dc266d314f
is: Q96NT5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:113235
constant: false
name: SLC46A1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR PPItx
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_d9d747b1_0c48_4655_9743_adab57214b92
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PEMT
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10400

http://identifiers.org/biomodels.db/MODEL1310110019#_515f91c2_3791_4988_97a6_abae0b90d32c
constant: false
is encoded by: hsa:4714
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O95169
name: NDUFB8
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_f8bd1ec6_8a13_481a_84a9_5cc395603d68
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P50053
initial amount: NaN
has only substance units: false
is encoded by: hsa:3795
name: KHK
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_c44f2b97_9c38_419c_a551_e8858575e34e
name: CA12
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:771
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR r2368
reactant: MODEL1310110019#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true

metaR NDPK1n
is: SBO:0000176
fast: false
modifier: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM atp c
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00002
is: HMDB00538
initial amount: NaN
is: CHEBI:30616
name: ATP(4-)

metaR r2113
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR DNDPt25m
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dCDP antiport
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110019#
reversible: false

metaR UDPDOLPT L
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is: SBO:0000176
kinetic law: MODEL1310110019#

metaR FE3MTP1
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
name: transport of ferrous iron into blood
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110019#_599d3eb6_81b5_491d_bca5_91658c50d18d
is: Q02218
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4967
is: SBO:0000252
name: OGDH
constant: false
initial amount: NaN

metaR NADS2
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.5.1
fast: false
modifier: MODEL1310110019#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: NAD synthase (glutamine-hydrolysing)
type: Reaction
kinetic law: MODEL1310110019#

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
fast: false
name: RE3050
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_eea44357_fa89_4023_9036_f67d36aa7688
type: Species
name: IMPDH1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3614
initial amount: NaN
is: C9JV30
boundary condition: true

metaR SQLSr
is: SBO:0000176
reactant: MODEL1310110019#
reversible: false
type: Reaction
fast: false
name: Squalene synthase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.5.1.21

metaR ADKd
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
type: Reaction
name: adenylate kinase (d form)
is: SBO:0000176

metaM ppp9 m
type: Species
is: HMDB00241
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Protoporphyrin
is: CHEBI:36159
is: SBO:0000247
constant: false
initial amount: NaN

metaM pe hs m
name: phosphatidylethanolamine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16038
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR RPEc
reactant: MODEL1310110019#
type: Reaction
name: ribulose 5-phosphate 3-epimerase
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
fast: false
is described by: ECO:0000134
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_da478a0d_b4d5_4cf7_a81c_dedcaed34eaa
type: Species
is encoded by: hsa:10587
initial amount: NaN
name: TXNRD2
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM mal L m
initial concentration: 1.0
is: HMDB00156
initial amount: NaN
is: CHEBI:15589
type: Species
constant: false
has only substance units: false
is: SBO:0000247
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6724f2ab_9e20_4aa3_9728_609d0af243f2
has only substance units: false
constant: false
is: P00390
initial concentration: NaN
type: Species
name: GSR
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2936

metaM Ssq23epx r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: CHEBI:15441
name: (S)-2,3-epoxysqualene
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01188
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_db7682b9_25fe_4d8c_ab82_699445d286ec
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55350
is: SBO:0000252
initial amount: NaN
name: VNN3
constant: false

metaR r1608
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r2365
is: SBO:0000185
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110019#_5196700e_21e5_4756_bd88_788a237b7e54
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4719
is: P28331
constant: false
type: Species
initial concentration: NaN
name: NDUFS1
boundary condition: true
has only substance units: false

metaR r2112
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_1194b8c9_37c1_4665_b7a4_6d5aa2f166d6
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: O43175
name: PHGDH
is encoded by: hsa:26227
initial amount: NaN

metaR SUCCTD
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_ae0833c1_8482_42c5_b8a4_78f84ab18571
has only substance units: false
is encoded by: hsa:4700
is: P56556
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: NDUFA6

metaM idp c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
initial concentration: 1.0
name: IDP(3-)
initial amount: NaN
is: CHEBI:58280
type: Species
is: HMDB03335

metaR r0386
fast: false
reactant: MODEL1310110019#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110019#
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e51877fd_556d_40d6_935d_fe479c22d375
has only substance units: false
is: P00374
initial concentration: NaN
constant: false
is encoded by: hsa:1719
type: Species
name: DHFR
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_5894391d_70c6_485a_80a1_fa8c427a3067
type: Species
initial amount: NaN
name: _642502_1_c
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:642502
has only substance units: false

metaR r1609
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_08059244_e467_4526_bc45_6c28ade85369
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:53905
is: Q9NRD9
initial concentration: NaN
name: DUOX1
initial amount: NaN
constant: false

metaR Htx
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reversible: true
name: H transporter, peroxisome
fast: false
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR r1015
type: Reaction
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
name: Na(+)/bile acid cotransporter Active transport
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:6469982 NOTES:
kinetic law: MODEL1310110019#
reversible: false

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#

metaR SPHMYLNtg
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
name: sphingomyelin intracellular transport
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR r2111
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0385
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110019#

metaM CE5120 m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: trans-2-cis-8-tetradecadienoyl-CoA
has only substance units: false
constant: false
type: Species
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN

metaR AHCYStr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
product: MODEL1310110019#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
name: S-Adenosyl-L-homocysteine intracellular diffusion
type: Reaction

metaM atp e
name: ATP(4-)
is: CHEBI:57299
type: Species
is: C00002
constant: false
has only substance units: false
is: HMDB00538
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR CYTK14n
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e0c9b1f7_8e7d_4067_bf2b_4e0aa364da77
has only substance units: false
initial concentration: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:4830
type: Species
name: NME1:NME2
boundary condition: true
initial amount: NaN

metaM f6p c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57579
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
is: SBO:0000247
name: D-Fructose 6-phosphate
boundary condition: false
type: Species
is: C00085

http://identifiers.org/biomodels.db/MODEL1310110019#_fc84b46d_6c18_47a2_8d46_5071008094c7
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: STS
is: P08842
is encoded by: hsa:412
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_5dae50ae_5646_4b57_8101_2069e97c9b75
initial amount: NaN
is encoded by: hsa:160851
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: Q86XP1
name: DGKH
initial concentration: NaN
has only substance units: false

metaM hco3 m
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: HMDB00595
is: C00288
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Bicarbonate
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_526d0786_0298_4e89_bfc0_44f2d43812df
is: P15328
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
type: Species
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110019#_f7faaa33_5229_4f28_ae34_3a79d656bc05
is encoded by: hsa:AA532636
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AA532636_1_m
constant: false
has only substance units: false

metaR r1606
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaR r2118
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_6479a3b7_6a79_4220_9da0_97ab2a26c093
has only substance units: false
name: COX6A2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1339
is: Q02221
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_b7e336df_5b9d_4090_b3ae_c1bbf1a923de
is: Q16836
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: HADH
is encoded by: hsa:3033
constant: false
type: Species

metaM idp e
has only substance units: false
name: IDP(3-)
is: CHEBI:58280
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB03335
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_c71a3dd1_f6f9_4db8_baa9_9aa6634d2a5a
initial amount: NaN
is encoded by: hsa:55276
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q96G03
name: PGM2
boundary condition: true

metaR biomass reaction
name: biomass_reaction
reversible: false
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM h2o g
is: HMDB02111
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
is: SBO:0000247

metaR IDPtn
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: IDP nuclear transport
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110019#

metaR r0384
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reactant: MODEL1310110019#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

metaM uri m
boundary condition: false
initial concentration: 1.0
is: HMDB00296
type: Species
has only substance units: false
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: uridine
is: CHEBI:16704
is: SBO:0000247
initial amount: NaN

metaM datp n
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
name: dATP
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:61404
constant: false
is: C00131
type: Species
initial concentration: 1.0

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
reversible: true

metaM adp c
is: SBO:0000247
initial amount: NaN
name: ADP
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16761
is: HMDB01341
boundary condition: false
has only substance units: false
is: C00008
is: http://identifiers.org/pubchem.compound/3310

metaR DNDPt8m
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
type: Reaction
fast: false
modifier: MODEL1310110019#
name: dADP transport via dUDP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_3191fc52_271c_474d_8b40_95df803f0e1b
has only substance units: false
initial concentration: NaN
name: DGKB
boundary condition: true
constant: false
is encoded by: hsa:1607
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_3ceb107a_7e94_46f6_8e5d_9df06631ff9a
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: _BG035985_1_c
is encoded by: hsa:BG035985
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r2117
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_5f9c6615_032c_4251_8a7a_62142bbe3140
is: SBO:0000252
has only substance units: false
name: PPA1
type: Species
boundary condition: true
is: Q15181
constant: false
is encoded by: hsa:5464
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_9e66f065_da53_4f17_9502_6ea188401acc
initial amount: NaN
initial concentration: NaN
is: F8VQS7
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:55967
name: NDUFA12

metaR r1607
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#

metaR Htr
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110019#
name: H transporter, endoplasmic reticulum

metaR PGI
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
name: glucose-6-phosphate isomerase

metaR ADSL2
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110019#
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM Lcystin e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
is: HMDB00192
name: L-cystine
is: CHEBI:16283
is: SBO:0000247

metaM arachd l
name: arachidonate
boundary condition: false
is: HMDB01043
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r1987
kinetic law: MODEL1310110019#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
reversible: false

metaR DPMVDc
is version of: http://identifiers.org/ec-code/4.1.1.33
kinetic law: MODEL1310110019#
is described by: ECO:0000134
reactant: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
type: Reaction
fast: false
modifier: MODEL1310110019#
product: MODEL1310110019#
name: diphosphomevalonate decarboxylase, cytosol
reversible: false

metaM dcmp c
is: CHEBI:57566
is: C00239
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01202
name: dCMP
initial concentration: 1.0

metaR r1010
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110019#
fast: false
name: Postulated transport reaction
reversible: true

metaM lac L e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: HMDB00190
is: CHEBI:16651
name: (S)-lactate
is: SBO:0000247
boundary condition: false

metaR BILGLCURtr
fast: false
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
is described by: ECO:0000000

metaR r2116
modifier: MODEL1310110019#
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM ppa c
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00237
initial concentration: 1.0
name: propionate
boundary condition: false
is: CHEBI:17272

metaR r2369
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110019#

metaM dtdp e
constant: false
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01274
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_4dd77f93_c4cf_4271_bbc1_dd0cea455a0a
has only substance units: false
name: DDO
constant: false
is: SBO:0000252
is encoded by: hsa:8528
type: Species
is: Q99489
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM mal L e
is: HMDB00156
name: (S)-malate(2-)
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
constant: false

metaR ADSL1
kinetic law: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
modifier: MODEL1310110019#
is: SBO:0000176
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
product: MODEL1310110019#
is described by: ECO:0000269
fast: false
type: Reaction

metaM prostgi2 e
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57403
constant: false
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
boundary condition: false
is: HMDB01335

metaM h2o e
is: C00001
has only substance units: false
name: H2O
is: SBO:0000247
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110019#_09665d7f_be88_4216_a36b_8a20002aa1c4
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: TXNRD3
is encoded by: hsa:114112
is: Q86VQ6
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d50a6261_56c6_4cee_97c9_07dca6049268
constant: false
initial amount: NaN
initial concentration: NaN
is: O00443
has only substance units: false
is: SBO:0000252
name: PIK3C2A
boundary condition: true
is encoded by: hsa:5286
type: Species

metaR r1604
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
is: SBO:0000185
type: Reaction

metaR LEUtec
modifier: MODEL1310110019#
reversible: true
name: L-leucine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110019#

metaM andrstandn r
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
has only substance units: false
name: 5alpha-androstane-3,17-dione
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00899
boundary condition: false
is: CHEBI:15994
is: SBO:0000247

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_fe36f1da_be5b_4329_b6b1_d7baabcfeb7a
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: P07195
initial concentration: NaN
type: Species
is encoded by: hsa:3945
name: LDHB

metaR DHFR
reactant: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000254
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
name: dihydrofolate reductase

http://identifiers.org/biomodels.db/MODEL1310110019#_20ef6dbe_c231_47a7_ba01_e9ebe456e734
initial amount: NaN
boundary condition: true
is encoded by: hsa:7263
is: SBO:0000252
constant: false
type: Species
name: TST
initial concentration: NaN
has only substance units: false
is: Q16762

metaR r0932
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110019#
fast: false
name: Transport reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_b3542acb_147e_4a65_819b_d629f285e88d
is encoded by: hsa:155184
is: SBO:0000252
type: Species
constant: false
is: Q6PXP3
initial amount: NaN
initial concentration: NaN
name: SLC2A7
has only substance units: false
boundary condition: true

metaR CYSO
product: MODEL1310110019#
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false

metaR MAN1PT2
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.13
name: mannose-1-phosphate guanylyltransferase (GDP)
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_f14d9090_3093_4ebe_b227_b9be19806285
name: SLC2A12
constant: false
is: SBO:0000252
is: Q8TD20
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:154091
type: Species
boundary condition: true

metaM HC00319 c
is: SBO:0000247
name: Malonate
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:30794
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6f97aff0_d2e2_4d6c_97ea_76884c28b263
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6888
name: TALDO1
constant: false
is: P37837
boundary condition: true
initial amount: NaN

metaR DHORTS
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
name: dihydroorotase
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
reactant: MODEL1310110019#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

metaR r2115
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_d267a3e9_39d8_490a_a8b0_06cb28598cb6
constant: false
has only substance units: false
initial concentration: NaN
name: CA14
is: SBO:0000252
type: Species
is encoded by: hsa:23632
is: A8K3J4
initial amount: NaN
boundary condition: true

metaR RE2660N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
name: RE2660
reactant: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
modifier: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true

metaR TRDR2
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (7296.1) or (7296.4) or (7296.2) or (7296.3) SUBSYSTEM: Miscellaneous EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:12435734,PMID:8577704,PMID:8999974 NOTES:Xia et al, 2003, JBC, 2141-2146
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
name: Thioredoxin (ubiquinone 10) reductase (NADPH)
reversible: false

metaR r1605
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110019#_c42036c1_3b8e_4383_88a8_87385d2012ea
initial amount: NaN
boundary condition: true
name: _T83654_1_c
has only substance units: false
is encoded by: hsa:T83654
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f1af11e6_81bd_422d_8730_3dc048e82b5b
is encoded by: hsa:5335
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: PLCG1
is: P19174

metaR PGK
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.2.3
fast: false
is described by: ECO:0000134
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110019#
name: phosphoglycerate kinase
reversible: true
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176

metaR ITCOAL1m
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is: SBO:0000176

metaR VALtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
reversible: true
reactant: MODEL1310110019#
name: L-valine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false

metaR r0931
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
fast: false
name: Transport reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR LEUTAm
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
name: leucine transaminase, mitochondrial

metaR RE2069C
reactant: MODEL1310110019#
type: Reaction
name: RE2069
reversible: true
product: MODEL1310110019#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_68aa0d5e_8759_45f5_8cca_aeb48e351528
boundary condition: true
is: Q8N5Z0
has only substance units: false
is: SBO:0000252
type: Species
name: AADAT
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51166

metaM his L m
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
type: Species
is: CHEBI:15971
name: L-histidine
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00177
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_6d93d39c_891a_4d99_9863_5a87178ad42e
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC2A1
is: P11166
is: SBO:0000252
type: Species
is encoded by: hsa:6513
constant: false
initial amount: NaN

metaR r1691
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110019#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR UDPG4E
name: UDPglucose 4-epimerase
is described by: ECO:0000134
kinetic law: MODEL1310110019#
fast: false
reversible: true
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is version of: http://identifiers.org/ec-code/5.1.3.2
reactant: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0b2f11c2_d3e5_4513_8d74_64d665e114cd
name: ACAA2
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: P42765
boundary condition: true
is encoded by: hsa:10449
initial concentration: NaN

metaM leuktrF4 e
is: SBO:0000247
name: leukotriene F4
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
initial concentration: 1.0
has only substance units: false
is: CHEBI:27491

metaR PHCDm
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
product: MODEL1310110019#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reactant: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000

metaM HC00319 m
name: Malonate
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:30794
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247

metaR r1546
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
fast: false

metaR GCHOLAte
reversible: true
name: bile acid intracellular transport
type: Reaction
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110019#

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

MODEL1310110019#
species: metaM ditp c
species: metaM acald c
species: metaM 4hpro LT m
species: metaM pro D c
species: metaM cyan c
species: metaM biliverd c
species: metaM dhf c
species: metaM betald c
species: metaM hpyr c
species: metaM gthox c
species: metaM 4abutn m
species: metaM dgtp c
species: metaM malcoa e
species: metaM gam e
species: metaM 2maacoa m
species: metaM duri e
species: metaM but e
species: metaM pa hs c
species: metaM HC01501 c
species: metaM 10fthf c
species: metaM urate c
species: metaM HC01496 m
species: metaM nicrnt c
species: metaM coa n
species: metaM HC01415 m
species: metaM dttp n
species: metaM 3mop m
species: metaM CE0849 m
species: metaM tym c
species: metaM h n
species: metaM gdp n
stoichiometry: 0.505626
species: metaM pram c
species: metaM CE2422 m
kind: MOLE
species: metaM pppg9 c
species: metaM glyc m
species: metaM 6thf e
species: metaM sphmyln hs c
species: metaM maltpt e
species: metaM Sfglutth c
species: metaM aacoa c
species: metaM xolest2 hs e
species: metaM dgtp e
species: metaM itp e
species: metaM Lcystin c
species: metaM ala L c
species: metaM lnlc r
species: metaM orot e
species: metaM pchol hs e
species: metaM dutp n
species: metaM HC02216 c
species: metaM lys L x
species: metaM dutp m
species: metaM hdca r
species: metaM HC00695 m
species: metaM coa e
species: metaM ipdp x
species: metaM tcynt m
species: metaM mercplaccys c
species: metaM HC02207 e
species: metaM ddcacoa m
species: metaM lpam m
value: -1000.0
value: 1000.0
species: metaM dhcrm hs c
species: metaM h2o2 e
species: metaM lnlccrn c
species: metaM CE5236 n
species: metaM dcholcoa c
name: ADH1B:ADH1C
species: metaM xu5p D c
species: metaM HC02202 c
species: metaM 4ppan c
species: metaM pail45p hs c
species: metaM his L c
species: metaM nh4 m
species: metaM CE4792 m
species: metaM 5dpmev c
species: metaM bilglcur r

http://identifiers.org/biomodels.db/MODEL1310110019#_a2e61a01_27d6_4a16_ba9d_eb6dfdc95d58
boundary condition: true
initial amount: NaN
is encoded by: hsa:10723
is: SBO:0000252
name: SLC12A7
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: Q9Y666

http://identifiers.org/biomodels.db/MODEL1310110019#_e1a0863f_104e_45b1_8fb9_0b693d629390
boundary condition: true
is: SBO:0000252
is encoded by: hsa:81537
initial concentration: NaN
is: Q9BX95
type: Species
has only substance units: false
name: SGPP1
constant: false
initial amount: NaN

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
is: C00124
is: HMDB00143
initial concentration: 1.0
name: D-Galactose
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM mal L c
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
has only substance units: false
type: Species
is: HMDB00156
constant: false

metaR r2098
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110019#

metaR COAtr
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
name: COA transporter, endoplasmic reticulum
product: MODEL1310110019#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR PPAt
type: Reaction
is described by: ECO:0000000
name: Propionate transport, diffusion
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reversible: false
is: SBO:0000185

metaM leu L c
type: Species
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
name: L-leucine
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00687
initial amount: NaN

metaM HC02217 e
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:27647

metaM HC01376 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial amount: NaN
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28692
type: Species
has only substance units: false
constant: false

metaR r1603
reversible: true
fast: false
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0e4df0c9_a6a5_4e99_b2b1_8ceba09311bc
name: INPP5D
is encoded by: hsa:3635
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q92835
type: Species

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_cc4cbb0c_1329_4ad4_abf7_e0627c67a256
initial amount: NaN
constant: false
is encoded by: hsa:257068
type: Species
name: PLCXD2
has only substance units: false
initial concentration: NaN
is: Q0VAA5
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_28a97e76_4edd_459c_8fa3_8ca649c85616
is encoded by: hsa:AI990637
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI990637_1_x
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_abd034b0_c178_4126_9496_b7c0e22d75c2
has only substance units: false
constant: false
is encoded by: hsa:7086
name: TKT
type: Species
initial concentration: NaN
is: E7EPA7
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR ADK3m
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: adentylate kinase (GTP)
fast: false

metaR 3SALATAi
is described by: ECO:0000304
name: 3-sulfino-alanine transaminase (irreversible)
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#

metaR r2099
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction

metaM pe hs e
is: CHEBI:16038
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
has only substance units: false
constant: false
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110019#_4f998af3_2702_4fb5_8796_28125d738f48
has only substance units: false
type: Species
initial concentration: NaN
is: Q6IBC0
constant: false
name: HMGCL
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3155

metaR PRAGSr
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110019#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110019#
name: phosphoribosylglycinamide synthase
kinetic law: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_863986d3_3121_449c_90db_62d83a441918
constant: false
is: SBO:0000252
type: Species
is: P42126
has only substance units: false
boundary condition: true
name: ECI1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1632

metaM atp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: HMDB00538
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
has only substance units: false
name: ATP(3-)

metaR r1600
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1544
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0a028267_99a3_4214_b26d_d7775a063dd3
initial amount: NaN
constant: false
is encoded by: hsa:7108
boundary condition: true
is: O76062
is: SBO:0000252
name: TM7SF2
has only substance units: false
type: Species
initial concentration: NaN

metaR DGK1
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110019#
name: deoxyguanylate kinase (dGMP:ATP)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaR LYStm
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
name: Lysine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR OCDCAtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110019#
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185

metaR r2007
fast: false
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
is: SBO:0000185

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_431bd0af_b84a_4765_8337_a2ce1a6f2d22
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:51095
name: TRNT1
is: Q96Q11
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1829
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#

metaM gal e
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
constant: false
name: D-Galactose
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C00124
is: HMDB00143

metaM leuktrF4 c
constant: false
is: HMDB06465
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:27491
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
name: leukotriene F4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8685bb8b_5737_4c63_9e69_40db4a82a621
boundary condition: true
is: P55084
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: HADHB
initial concentration: NaN
is encoded by: hsa:3032
initial amount: NaN

metaR P5CR
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is described by: ECO:0000134
is: SBO:0000176
name: pyrroline-5-carboxylate reductase
fast: false
reversible: false
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_73ff590f_b98a_40ec_b691_86c747b2ba46
is: Q9NRD8
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: DUOX2
is encoded by: hsa:50506
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c250dd95_45ce_4386_9eb7_ec7e3910a204
is encoded by: hsa:AU149534
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AU149534_1_c
type: Species
constant: false

metaM leu L e
constant: false
is: SBO:0000247
is: HMDB00687
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
type: Species
is: CHEBI:15603
name: L-leucine
has only substance units: false
initial amount: NaN

metaR GLCter
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110019#
name: glucose transport, endoplasmic reticulum

metaM lys L x
type: Species
is: CHEBI:32551
name: L-lysinium(1+)
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false

metaM Lcystin c
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
has only substance units: false
is: CHEBI:16283
initial amount: NaN
type: Species
is: SBO:0000247
name: L-cystine
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_59a5df3e_a027_4324_90aa_5ddce4d25315
constant: false
has only substance units: false
name: MAOA
initial amount: NaN
is encoded by: hsa:4128
boundary condition: true
initial concentration: NaN
is: Q53YE7
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_03f81536_3dba_409c_a51e_7a536b6ce297
boundary condition: true
is encoded by: hsa:83549
is: Q5JT09
name: UCK1
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM CE2433 m
constant: false
is: CHEBI:57795
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false

metaR COAtp
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: coenzyme A transport, peroxisomal
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
type: Reaction

metaM atp m
is: HMDB00538
name: ATP(4-)
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00002
is: CHEBI:57299

metaR 10FTHFtm
product: MODEL1310110019#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion

metaR PPItr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Diphosphate transporter, endoplasmic reticulum
reactant: MODEL1310110019#
is: SBO:0000185

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110019#
is: SBO:0000176
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8949fc43_982f_43f9_88c9_cfad08b300f1
initial amount: NaN
initial concentration: NaN
has part: P07195
is: SBO:0000297
boundary condition: true
name: LDHA:LDHB
has only substance units: false
constant: false
is encoded by: hsa:3945
type: Species

metaR r2119
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#

metaR GGH 6DHFe
reactant: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reversible: false
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110019#_acfef16d_11e4_4baa_b2eb_c205a5167611
has only substance units: false
is encoded by: hsa:51
initial amount: NaN
is: Q15067
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ACOX1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_9b873226_80e5_4daa_8ec1_f86eb9ca92ea
is encoded by: hsa:92483
name: LDHAL6B
has only substance units: false
is: Q9BYZ2
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR TYRt
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
fast: false
name: L-tyrosine transport

metaM arachd c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:32395
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110019#_34366366_bdfb_41fe_8fcc_d9d37b7d1d96
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ALAS1
is encoded by: hsa:211
constant: false
is: Q5JAM2

metaR r2093
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_f2066041_4d44_43d4_87ab_e1f7c266aa32
is encoded by: hsa:728226
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _728226_1_m
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9463f1ca_e8b9_402e_bafe_a9c8eca49eef
constant: false
name: ENPP3
is: SBO:0000252
initial concentration: NaN
is: Q308M7
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5169
initial amount: NaN

metaR URIt
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
fast: false
reversible: true
name: uridine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_eda541d9_d941_48d1_a7e2_2ebabec169b2
initial concentration: NaN
constant: false
name: _AF116616_1_m
is encoded by: hsa:AF116616
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR PAIL HStn
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000

metaM adp m
constant: false
is: SBO:0000247
is: C00008
name: ADP
has only substance units: false
is: HMDB01341
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_6c28f611_bdae_4235_a9bc_bb6bb6fd4f7c
constant: false
name: SLC2A9
initial amount: NaN
has only substance units: false
is: Q9NRM0
is encoded by: hsa:56606
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_d8f07ea0_a3ce_46cd_8db9_83b15480417f
boundary condition: true
is: SBO:0000252
name: ALPPL2
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:251
initial amount: NaN
is: P10696
constant: false

metaM leuktrD4 r
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28666
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
type: Species
is: SBO:0000247
name: Leukotriene D4
constant: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_70608d65_6703_4e96_bcb8_2576b253381d
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PDHB
is: P11177
has only substance units: false
type: Species
is encoded by: hsa:5162
constant: false
boundary condition: true

metaR r2094
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
reversible: true

metaR DITPtn
is described by: ECO:0000000
product: MODEL1310110019#
reversible: true
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dITP nuclear transport
type: Reaction
is: SBO:0000185

metaR COAtn
is: SBO:0000185
fast: false
name: coenzyme A transport, nuclear
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_5a205805_7b79_4614_94c4_31eba09fd81f
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: AKR1C4
is encoded by: hsa:1109
initial amount: NaN
is: P17516
has only substance units: false

metaM dtdp n
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_a0358de0_ce99_4db3_93d6_0f462e3e5206
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: NT5C2
is encoded by: hsa:22978
initial concentration: NaN
is: P49902
constant: false
is: SBO:0000252

metaR ASCBOX
product: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
name: ascorbic acid oxidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110019#

metaM 4abut m
is: HMDB00112
has only substance units: false
is: SBO:0000247
is: CHEBI:16865
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: C00334
constant: false
initial amount: NaN
name: 4-Aminobutanoate

metaR RE1521M
is: SBO:0000176
modifier: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
name: RE1521
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_1b7bf3ca_c453_4800_8f9d_86d351224166
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4047
is: SBO:0000252
is: E9PEI9
has only substance units: false
type: Species
initial amount: NaN
name: LSS

metaR BETALDHxm
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reactant: MODEL1310110019#
type: Reaction
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b371def0_46b1_4137_9738_cfa02849495c
is: SBO:0000252
boundary condition: true
name: UEVLD
is: Q8IX04
has only substance units: false
is encoded by: hsa:55293
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_6eab343b_4a46_470b_90a2_e1bb46048d8b
boundary condition: true
is encoded by: hsa:10935
is: P30048
constant: false
name: PRDX3
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM arachd e
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: arachidonate
is: HMDB01043
boundary condition: false

metaR COAtm
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110019#
name: CoA transporter

http://identifiers.org/biomodels.db/MODEL1310110019#_832a105f_5869_4845_94d1_b226e71990cc
constant: false
is: P09972
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ALDOC
is encoded by: hsa:230
boundary condition: true
has only substance units: false
type: Species

metaR r1540
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaR r1693
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_aefd6076_c26b_4763_8686_a649b5472b2f
name: HK1
is encoded by: hsa:3098
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P19367
constant: false

metaR r2095
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000

metaR r2096
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110019#

metaR ALADGLNexR
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000304
kinetic law: MODEL1310110019#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110019#
type: Reaction
fast: false
reactant: MODEL1310110019#

metaM dtdp m
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
type: Species
name: dTDP
is: C00363
boundary condition: false
is: HMDB01274
is: CHEBI:58369
constant: false
is: SBO:0000247
has only substance units: false

metaR RETI2
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
name: retinol isomerase (9-cis)

metaR GLYCLTtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
name: glycolate transport into peroxisome
reversible: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaM tcynt m
boundary condition: false
has only substance units: false
constant: false
is: HMDB01453
is: CHEBI:18022
is: SBO:0000247
name: thiocyanate
initial concentration: 1.0
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN

metaR r1018
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR GLNSERNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false

metaR r0670
type: Reaction
fast: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaR ACETONEt2
is described by: ECO:0000269
name: acetone transport via proton symport
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110019#_7542dcfc_6351_48c9_b2e7_397d8e30c263
boundary condition: true
is encoded by: hsa:84076
initial concentration: NaN
name: TKTL2
type: Species
is: Q9H0I9
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM adp n
initial amount: NaN
is: HMDB01341
is: CHEBI:456216
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

http://identifiers.org/biomodels.db/MODEL1310110019#_8767bf7d_dac2_44cc_9999_30fd51758bbb
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2235
is: P22830
initial amount: NaN
constant: false
initial concentration: NaN
name: FECH
boundary condition: true

metaR r1692
product: MODEL1310110019#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaM HC02217 c
initial amount: NaN
is: CHEBI:27647
is: SBO:0000247
type: Species
has only substance units: false
name: prostaglandin-g2
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false

metaR r0166
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: false
product: MODEL1310110019#
fast: false
type: Reaction
is described by: ECO:0000000
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reactant: MODEL1310110019#

metaM 2maacoa m
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57335
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
is: HMDB01157
is: SBO:0000247
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_542c5416_38f2_4c27_b411_d761bcec6540
name: ADH1C
has only substance units: false
type: Species
is: P00326
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:126
constant: false
is: SBO:0000252

metaR r2097
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR RETI3
name: retinol isomerase (13-cis)
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
reversible: true
kinetic law: MODEL1310110019#

metaR G6PDA
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
reversible: false
product: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.99.6
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110019#
name: glucosamine-6-phosphate deaminase

http://identifiers.org/biomodels.db/MODEL1310110019#_89911d94_50b1_4795_bdfb_81ff2a18cec3
has only substance units: false
boundary condition: true
is: SBO:0000252
name: CTPS2
is encoded by: hsa:56474
is: Q9NRF8
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM pe hs c
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16038
name: phosphatidylethanolamine
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN

metaR FADDPle
kinetic law: MODEL1310110019#
name: FAD diphosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_26c5f370_650c_4156_b00a_a777c32af601
initial amount: NaN
has only substance units: false
name: NDUFA4L2
is: Q9NRX3
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:56901
initial concentration: NaN

metaM cyan e
is: CHEBI:18407
is: HMDB02084
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: hydrogen cyanide
type: Species
is: SBO:0000247

metaM ile L e
is: HMDB00172
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17191
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
name: L-isoleucine
initial amount: NaN
has only substance units: false

metaM gln L c
is: CHEBI:18050
has only substance units: false
constant: false
type: Species
is: HMDB00641
initial concentration: 1.0
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_485379b3_557e_45a9_8b60_25567362d249
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: _LOC728997_1_c
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:LOC728997

http://identifiers.org/biomodels.db/MODEL1310110019#_ac03d218_2f70_4ce6_a6b6_ab73971d4a14
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7296
type: Species
constant: false
name: TXNRD1
is: SBO:0000252

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110019#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110019#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
reactant: MODEL1310110019#
reversible: false

metaR RETI1
product: MODEL1310110019#
is described by: ECO:0000000
name: retinol isomerase (11-cis)
is: SBO:0000176
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR r2012
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110019#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d4f6111c_1382_4f19_8d75_ad27aec6744a
name: SLC24A4
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q8NFF2
initial amount: NaN
is encoded by: hsa:123041
has only substance units: false
is: SBO:0000252

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110019#
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.13
kinetic law: MODEL1310110019#
name: hydrolysis of cholesterol ester by cholesterol esterase
is: SBO:0000176
reversible: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_c5507546_c7f4_4e16_80dd_8bf016077f57
has only substance units: false
is encoded by: hsa:160728
is: SBO:0000252
is: Q8N695
type: Species
boundary condition: true
initial concentration: NaN
name: SLC5A8
initial amount: NaN
constant: false

metaR r0527
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
reversible: true
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1c76c5eb_f4af_48c2_adc9_c6879d07ff84
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q8N142
is encoded by: hsa:122622
boundary condition: true
constant: false
type: Species
name: ADSSL1
is: SBO:0000252

metaR r2090
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_e2c591f0_ef56_4a0c_85d6_6555281d824b
is: Q12882
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1806
constant: false
has only substance units: false
initial amount: NaN
name: DPYD

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction
is described by: ECO:0000000

metaM 13 cis retnglc c
type: Species
initial concentration: 1.0
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1
is: SBO:0000247
name: 13-cis-retinoyl glucuronide
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28870
constant: false
is: HMDB03141

metaM mi134p c
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
has only substance units: false
is: CHEBI:58414
is: HMDB01143
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial concentration: 1.0
is: SBO:0000247

metaM val L e
name: L-valine
type: Species
constant: false
is: HMDB00883
initial amount: NaN
has only substance units: false
is: CHEBI:16414
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_6d413811_80f0_4be0_8eaf_a8eecc66fa5e
initial concentration: NaN
is encoded by: hsa:6574
is: SBO:0000252
boundary condition: true
constant: false
is: Q8WUM9
name: SLC20A1
has only substance units: false
type: Species
initial amount: NaN

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_44230f7b_bc55_445f_bb81_52531c47e5e8
constant: false
is: SBO:0000252
has only substance units: false
is: P23786
name: CPT2
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1376

http://identifiers.org/biomodels.db/MODEL1310110019#_93888795_2b7a_4ada_a6f2_cb99b8f27383
name: ACSL5
is encoded by: hsa:51703
is: Q9ULC5
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR GALt4
reversible: true
name: galactose transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM no e
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16480
constant: false
initial amount: NaN
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
is: C00533
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2d4e8d93_114d_4a63_9e5a_585d3ae46cca
constant: false
is: B7Z6M3
name: DGKZ
has only substance units: false
type: Species
is encoded by: hsa:8525
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r0170
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:

metaR EX 13 cis retnglc LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 13-cis-retinoyl glucuronide exchange
type: Reaction

metaM bildglcur c
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
is: HMDB03325
boundary condition: false
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
constant: false

metaR PPPGOm
reversible: false
fast: false
name: protoporphyrinogen oxidase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.3.3.4
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110019#_b509e7b1_8a4c_4c30_b0b4_96dccb266f12
is: P12268
is encoded by: hsa:3615
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: IMPDH2
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f97caa97_499f_4dcf_98af_3e7209548375
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: ND1
boundary condition: true
is encoded by: hsa:4535
is: Q85KV6
constant: false
initial amount: NaN

metaM 3sala c
is: C00606
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
type: Species
is: CHEBI:61085
constant: false
initial amount: NaN
name: 3-Sulfino-L-alanine
initial concentration: 1.0

metaR RE1254C
product: MODEL1310110019#
type: Reaction
fast: false
name: RE1254
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000

MODEL1310110019
species: metaM Rtotal c
species: metaM HC01376 m
reaction: metaR EX ser L LPAREN e RPAREN
reaction: metaR CYTK5n
species: metaM dudp c
reaction: metaR r0944
reaction: metaR MAGt
reaction: metaR FERO
species: metaM aacoa c
reaction: metaR ACACT1rm
reaction: metaR EX dtmp LPAREN e RPAREN
species: metaM leuktrA4 e
species: metaM bhb e
species: metaM 5dpmev c
species: metaM creat c
reaction: metaR EX dpcoa LPAREN e RPAREN
reaction: metaR EX etoh LPAREN e RPAREN
reaction: metaR CSNATm
species: metaM btn e
species: metaM acnam n
reaction: metaR r2323
reaction: metaR GGH 10FTHF6GLUe
species: metaM tsul m
species: metaM dpcoa e
reaction: metaR r0774
reaction: metaR r0960
reaction: metaR RE0453C
reaction: metaR CITtbm
reaction: metaR r1106
reaction: metaR EX 4mop LPAREN e RPAREN
reaction: metaR GGH 7DHFe
reaction: metaR r1608
reaction: metaR r0603
species: metaM dgmp c
species: metaM glyb c
reaction: metaR AIRCr
reaction: metaR RADH2
reaction: metaR r0683
reaction: metaR BTNt4i
reaction: metaR r0156
species: metaM retinal cis 13 c
species: metaM ppi r
reaction: metaR GLCt1r
species: metaM bilirub r
reaction: metaR RE2660N
species: metaM datp n
species: metaM nrpphr e
reaction: metaR RE0958E
reaction: metaR r0002
species: metaM nadph r
reaction: metaR DNDPt22m
species: metaM prostgf2 c
reaction: metaR PI345P5P
reaction: metaR PSSA1 hs
reaction: metaR FORt2m
reaction: metaR r0789
species: metaM 4ppcys c
reaction: metaR RE1532M
reaction: metaR RAI1
reaction: metaR FUMTSULtm
species: metaM dag hs c
species: metaM inost e
species: metaM andrstrn r
reaction: metaR r1654
name: Thiele2013 - Vagina squamous epithelial cells
species: metaM HC01603 c
reaction: metaR MI134PP
reaction: metaR r2365
species: metaM 4ppan c
reaction: metaR r2320
species: metaM xmp c
reaction: metaR r0618
reaction: metaR UPP3S
reaction: metaR ALASm
reaction: metaR r1587
species: metaM thf c
species: metaM HC02203 e
reaction: metaR GMPR
reaction: metaR PROSTGF2t
reaction: metaR RETt

metaM e4p c
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
constant: false
boundary condition: false
has only substance units: false
is: C00279
is: HMDB01321
is: SBO:0000247
initial amount: NaN
type: Species
name: D-Erythrose 4-phosphate
is: CHEBI:16897

metaR GLXO1
modifier: MODEL1310110019#
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
fast: false
reactant: MODEL1310110019#
name: glyoxylate oxidase

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM ile L c
initial amount: NaN
boundary condition: false
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: CHEBI:17191
initial concentration: 1.0
constant: false
name: L-isoleucine
has only substance units: false

metaM gln L e
constant: false
type: Species
has only substance units: false
is: HMDB00641
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: L-glutamine
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR UGT1A10r
type: Reaction
product: MODEL1310110019#
fast: false
is described by: ECO:0000134
is: SBO:0000176
reversible: true
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is version of: http://identifiers.org/ec-code/2.4.1.17
reactant: MODEL1310110019#
modifier: MODEL1310110019#

metaR MCITS
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: 2-methylcitrate synthase
kinetic law: MODEL1310110019#

metaM cyan c
boundary condition: false
is: CHEBI:18407
is: HMDB02084
has only substance units: false
type: Species
name: hydrogen cyanide
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_fd571b8d_1d03_4c75_ace6_6aa851703e93
is: SBO:0000252
is encoded by: hsa:51
type: Species
constant: false
is: B4DK61
has only substance units: false
initial amount: NaN
name: ACOX1
boundary condition: true
initial concentration: NaN

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_cf2b48d5_10ae_44e5_a7cc_56e3aaa608c7
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: CA1
is encoded by: hsa:759
boundary condition: true
initial concentration: NaN
is: P00915

http://identifiers.org/biomodels.db/MODEL1310110019#_d6bb7ba1_7c4d_4383_b684_f2e339922ea9
boundary condition: true
is encoded by: hsa:3945
initial amount: NaN
initial concentration: NaN
name: LDHB
type: Species
constant: false
has only substance units: false
is: P07195
is: SBO:0000252

metaR r2092
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_6cf5e634_e7ef_427f_9984_3d66f895c5cc
initial concentration: NaN
is: Q8N3E9
is: SBO:0000252
name: PLCD3
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:113026
initial amount: NaN

metaM nicrns c
name: Nicotinate D-ribonucleoside
initial concentration: 1.0
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06809

metaM 13 cis retnglc e
name: 13-cis-retinoyl glucuronide
initial concentration: 1.0
is: CHEBI:28870
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB03141
is: SBO:0000247
type: Species
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1

metaM val L c
name: L-valine
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
initial amount: NaN
is: CHEBI:16414
initial concentration: 1.0
is: SBO:0000247

metaM hco3 c
name: Bicarbonate
is: CHEBI:17544
constant: false
has only substance units: false
boundary condition: false
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_109f3a23_6fd7_4ea1_aba0_3ad89482ac1d
is encoded by: hsa:6390
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: SDHB
is: P21912
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e71d689f_6714_4959_9f49_ac7ce82bece5
has only substance units: false
is: P00492
initial amount: NaN
type: Species
name: HPRT1
is: SBO:0000252
constant: false
is encoded by: hsa:3251
boundary condition: true
initial concentration: NaN

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM btn e
boundary condition: false
initial amount: NaN
constant: false
is: C00120
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00030
is: CHEBI:3420
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_5ed3c749_498e_450a_abba_ad20c43bd931
is encoded by: hsa:1468
constant: false
name: SLC25A10
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q9UBX3
has only substance units: false
initial amount: NaN

metaR 25HVITD3t
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical
reversible: false
is described by: ECO:0000000
name: 25-hydroxyvitamin D3 transport from cytoplasm

http://identifiers.org/biomodels.db/MODEL1310110019#_a069a114_2ace_4ecf_a51b_bb10930a7c92
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:377677
initial concentration: NaN
is: Q8N1Q1
boundary condition: true
name: CA13

http://identifiers.org/biomodels.db/MODEL1310110019#_5e27fbce_dbce_4228_b851_264948cc5945
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79646
is: Q9H999
initial amount: NaN
constant: false
has only substance units: false
name: PANK3
is: SBO:0000252
type: Species

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM glyc c
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Glycerol
is: C00116
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: HMDB00131
has only substance units: false
type: Species
boundary condition: false

metaR r0596
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110019#
reversible: false

metaR FOLR2
fast: false
reversible: false
product: MODEL1310110019#
type: Reaction
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM orn m
is: CHEBI:46912
is: SBO:0000247
initial amount: NaN
is: HMDB00214
type: Species
boundary condition: false
name: Ornithine
is: C01602
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaM CE1926 e
boundary condition: false
is: CHEBI:15748
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
name: gama-carboxyethyl-hydroxychroman
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_6bcffa18_ffa9_47db_9e9b_20353e00f709
constant: false
is encoded by: hsa:55350
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: VNN3
is: SBO:0000252
initial concentration: NaN

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110019#
is: SBO:0000185

metaM fgam c
constant: false
is: CHEBI:58426
is: C04376
is: HMDB01308
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
has only substance units: false
is: SBO:0000247
boundary condition: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

http://identifiers.org/biomodels.db/MODEL1310110019#_6837ec1d_beed_4b18_a312_1d62e7de1629
name: HAO1
boundary condition: true
has only substance units: false
is encoded by: hsa:54363
constant: false
is: SBO:0000252
is: Q9UJM8
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_41d737c4_51bc_4ef6_98ee_54273662f9e5
has only substance units: false
is: P30613
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: PKLR
constant: false
boundary condition: true
is encoded by: hsa:5313

metaR FE2tm
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
reversible: false
name: iron (II) transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false

metaR RE1796R
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reactant: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: RE1796
reversible: true

metaM hxan c
initial amount: NaN
is: CHEBI:17368
is: C00262
name: Hypoxanthine
type: Species
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
has only substance units: false
is: HMDB00157
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_8f8f02ef_ec34_4e3e_9e0a_0e7a6198556c
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:53
initial amount: NaN
is: SBO:0000252
is: E9PCI1
name: ACP2

http://identifiers.org/biomodels.db/MODEL1310110019#_c753b36a_ca92_4abe_8734_9b6a0ab09209
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: Q308M7
initial amount: NaN
is encoded by: hsa:5169
boundary condition: true
has only substance units: false
name: ENPP3

metaM succoa m
type: Species
boundary condition: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Succinyl-CoA
constant: false
is: CHEBI:57292
has only substance units: false

metaM btn c
is: C00120
constant: false
type: Species
initial amount: NaN
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
is: SBO:0000247
boundary condition: false
name: Biotin
has only substance units: false
initial concentration: 1.0

metaR ILETA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: isoleucine transaminase
is described by: ECO:0000269
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM ppcoa x
constant: false
is: C00100
type: Species
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
is: SBO:0000247
has only substance units: false
is: HMDB01275
boundary condition: false
initial concentration: 1.0
name: Propanoyl-CoA

metaR GLYt2r
name: glycine reversible transport via proton symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false

metaR ASPDTDe
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
name: D-aspartate transport, extracellular
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: true
is described by: ECO:0000134

metaR ADSS
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.4.4
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277

metaR r0595
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reversible: false
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_1bf197ec_9ae1_4316_ba3b_4ff40227d6b2
constant: false
initial concentration: NaN
type: Species
is: Q8WY07
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC7A3
is encoded by: hsa:84889
is: SBO:0000252

metaM mal L x
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: (S)-malate(2-)
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM gluside hs c
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
is: SBO:0000247
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
type: Species
is: CHEBI:18368
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_81ebe89f_9785_4d99_8225_f844dcd90850
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9Y259
name: CHKB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1120
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_4ac89155_d525_4458_8b82_b6672f0e4df3
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: PPA2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27068
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e20e51ef_b770_43c0_bb95_4662ccf9e32b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29922
name: NME7
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR SERtN1
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true
name: Serine transport (Na, H coupled)
is described by: ECO:0000269
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534

metaM dcyt n
is: HMDB00014
name: 2'-deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15698
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b7f8ff60_5798_445f_a396_6ec174fa49f2
is encoded by: hsa:6319
name: SCD
constant: false
is: O00767
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r1547
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_7c581efb_e2fe_4180_bec5_8208249d6045
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: TUSC3
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:7991

http://identifiers.org/biomodels.db/MODEL1310110019#_1f653264_b062_4b1f_9213_1ccf289d9600
is encoded by: hsa:1337
initial amount: NaN
constant: false
name: COX6A1
is: P12074
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_360b4484_d3ce_4c38_8f76_eee5396cc1af
constant: false
is encoded by: hsa:1716
initial concentration: NaN
is: E5KSL5
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: DGUOK
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM tcynt e
is: CHEBI:18022
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01453
is: SBO:0000247
constant: false
boundary condition: false
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaM bildglcur e
constant: false
type: Species
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
is: CHEBI:58471
is: SBO:0000247
has only substance units: false
is: HMDB03325
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaM hxan e
is: CHEBI:17368
name: hypoxanthine
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM xol7ah2al m
is: HMDB06894
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
constant: false
is: CHEBI:27428

metaM no c
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
name: Nitric oxide
constant: false
initial amount: NaN
is: C00533
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB03378

http://identifiers.org/biomodels.db/MODEL1310110019#_085c4f1b_15d8_4a93_aa9b_b69aa60373a0
has part: E9KL44
has part: P55084
is encoded by: hsa:3032
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN
name: HADHA:HADHB
is: SBO:0000297
has only substance units: false
constant: false
type: Species
boundary condition: true

metaM ethamp c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
initial amount: NaN
name: ethamp[c]
is: CHEBI:58190

metaM lnlccrn c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
is: SBO:0000247
name: Linoleyl carnitine
is: HMDB06469

metaR r1548
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ICDHyrm
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_e4990de3_02a6_44aa_b442_b8452d20d6a6
is encoded by: hsa:4967
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: OGDH
initial amount: NaN
is: SBO:0000252
is: Q02218
type: Species

metaR ASNSERNaEx
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
reversible: false
product: MODEL1310110019#
is described by: ECO:0000269

metaR r0679
product: MODEL1310110019#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110019#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaM val L m
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
name: L-valine
type: Species
is: CHEBI:16414
boundary condition: false
is: SBO:0000247

metaM CE0849 m
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial amount: NaN
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
initial concentration: 1.0
is: CHEBI:57795
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR r0391
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaR CHAT
name: Choline O-acetyltransferase
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_21b5c331_d3af_4ee7_91fa_b5ad801f8c1b
name: SLC7A10
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:56301
is: Q9NS82

metaR 5ADTSTSTERONEte
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
reactant: MODEL1310110019#
is: SBO:0000185

metaR HPYRRy
name: Hydroxypyruvate reductase (NADPH)
type: Reaction
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.79
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_edfc3039_2295_41ca_baf1_b1fcb687f5e0
is: SBO:0000252
initial concentration: NaN
name: HADHB
is: P55084
initial amount: NaN
type: Species
is encoded by: hsa:3032
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b8dc65eb_3fbd_4600_bd37_be891fd5112f
name: IDI2
is: Q9BXS1
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:91734
type: Species
initial concentration: NaN

metaR r0390
product: MODEL1310110019#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:

metaR r2372
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaM ile L m
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
initial concentration: 1.0
is: HMDB00172
initial amount: NaN
boundary condition: false
has only substance units: false
name: L-isoleucine
is: SBO:0000247
is: CHEBI:17191

metaM sphs1p r
boundary condition: false
is: CHEBI:60119
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
type: Species
initial amount: NaN
is: HMDB00277
has only substance units: false
constant: false

metaR r1449
type: Reaction
name: EC:1.3.3.6
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_0436a6c1_5ec4_4576_b456_c3fde4ccf000
initial amount: NaN
has only substance units: false
name: MGLL
type: Species
is: Q99685
initial concentration: NaN
is encoded by: hsa:11343
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_74a874dd_6401_4f7d_a5ad_7d3ce2659afd
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: P24311
name: COX7B
initial amount: NaN
constant: false
is encoded by: hsa:1349

metaR EX crmp hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ceramide 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_8ed1cb72_b7d5_4eef_aba9_1178229208ae
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: PISD
is: Q9UG56
is encoded by: hsa:23761
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_988ad62c_2465_47a5_aecc_41177c234871
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:65010
has only substance units: false
initial concentration: NaN
is: Q548A7
is: SBO:0000252
name: SLC26A6
type: Species

metaR r0591
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
product: MODEL1310110019#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_3b77f0a8_94c5_4fa4_832c_d7737fa0f0d4
boundary condition: true
constant: false
is: O14495
type: Species
has only substance units: false
name: PPAP2B
is encoded by: hsa:8613
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:27466
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_104f4b1a_3e74_4bd1_9505_8b29649f00aa
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: E7EQF2
is: SBO:0000252
name: CROT
is encoded by: hsa:54677

metaR PGCD
fast: false
kinetic law: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.95
reactant: MODEL1310110019#
type: Reaction
name: phosphoglycerate dehydrogenase
modifier: MODEL1310110019#

metaM hom L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
is: SBO:0000247
name: L-homoserine
initial concentration: 1.0
is: HMDB00719
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15699
has only substance units: false

metaM 4abutn m
is: CHEBI:58264
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01080
type: Species
constant: false
name: 4-ammoniobutanal
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaM tcynt c
is: HMDB01453
is: CHEBI:18022
is: SBO:0000247
boundary condition: false
name: thiocyanate
has only substance units: false
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r0926
reversible: false
fast: false
reactant: MODEL1310110019#
name: Postulated transport reaction
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000

metaM alpam m
name: S-aminomethyldihydrolipoamide
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06239
initial amount: NaN

metaR r2371
reversible: true
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_f9a5b96e_6d14_46e5_b06b_2574fa78bbb9
is: P56181
has only substance units: false
name: NDUFV3
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4731

metaR r1116
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR GLUtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
name: intracellular transport
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false

metaM gln L m
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00641
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r0594
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR CYSALANaEx
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110019#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000269

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR PHACCOAGLNAC
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e6acd3e5_cf96_47c4_8aaa_5037b53b7630
name: NDUFB6
boundary condition: true
is encoded by: hsa:4712
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: O95139

metaR r1117
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
name: Facilitated diffusion
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_cce8d033_9de0_4684_aba6_e6ef60d757a2
initial amount: NaN
is encoded by: hsa:229
constant: false
is: P05062
initial concentration: NaN
name: ALDOB
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_23b78527_5a29_4d24_be4c_8abdb637540d
is encoded by: hsa:9990
initial concentration: NaN
boundary condition: true
constant: false
name: SLC12A6
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9UHW9

metaR MDHm
reversible: true
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.37
is: SBO:0000176
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical

metaR RE3421R
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110019#
fast: false
type: Reaction
name: RE3421
reactant: MODEL1310110019#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_d0f101b2_aee0_478e_bfa2_d9a3ff230ea4
name: NDUFA7
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4701
boundary condition: true
is: Q6FG42
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_de6834de_19f9_48f0_bb91_7ea9b054cfb8
initial concentration: NaN
has only substance units: false
boundary condition: true
name: TXNRD1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7296

metaR H2Otm
fast: false
product: MODEL1310110019#
name: H2O transport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
modifier: MODEL1310110019#
reversible: true

metaR r0522
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
reversible: false
reactant: MODEL1310110019#
fast: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110019#
type: Reaction

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110019#

metaR ACNAMtn
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: N-acetylneuraminate nuclear import

http://identifiers.org/biomodels.db/MODEL1310110019#_0305ead6_538e_483e_8c96_873eb0dfb7e0
type: Species
initial concentration: NaN
has only substance units: false
is: Q9Y6M9
name: NDUFB9
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4715

metaR GLYBtm
fast: false
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
reactant: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
boundary condition: false
is: CHEBI:16704
initial amount: NaN
is: HMDB00296
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00299
constant: false
type: Species

metaM gluside hs r
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:18368
type: Species
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
has only substance units: false

metaM hom L e
constant: false
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00719
name: L-homoserine
type: Species
is: CHEBI:15699
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6c6e2aa6_455c_42f8_9e89_d48a3af612db
is: SBO:0000252
boundary condition: true
name: _T83654_1_e
initial concentration: NaN
is encoded by: hsa:T83654
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_b5dd6a98_f96d_4a20_9625_2d42214228e1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GCK
is encoded by: hsa:2645

metaM nmn c
is: HMDB00229
constant: false
initial concentration: 1.0
name: NMN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: CHEBI:14649
has only substance units: false
is: C00455
initial amount: NaN

metaR r1446
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110019#
name: EC:1.3.3.6
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
fast: false
is: SBO:0000176

metaR GUAPRT
modifier: MODEL1310110019#
product: MODEL1310110019#
name: guanine phosphoribosyltransferase
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT

metaM C05279 m
is: SBO:0000247
is: CHEBI:28387
constant: false
is: HMDB11123
boundary condition: false
initial amount: NaN
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
type: Species

metaR H2Otg
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110019#
name: H2O transport, Golgi apparatus
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_d4a835ad_f382_4b63_a648_86ad425fcfba
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: MPI
is encoded by: hsa:4351
is: P34949
boundary condition: true
constant: false

metaM gchola c
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58235
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
name: glycocholate
is: SBO:0000247
initial amount: NaN
is: HMDB00138
constant: false

metaR PRPPS
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
fast: false
name: phosphoribosylpyrophosphate synthetase

metaM CE5117 m
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57923
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial amount: NaN

metaR r0523
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2

metaR r2376
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR r2121
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_5e0c140d_2664_47b2_ab9e_7ea26e6c386f
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P36969
initial amount: NaN
name: GPX4
boundary condition: true
constant: false
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110019#_534735cd_7e48_400b_89c6_87f5bc4420ca
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AI620219_1_m
is encoded by: hsa:AI620219
constant: false
boundary condition: true

metaR ASNtN1
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
name: Asparagine transport (Na, H coupled)
reactant: MODEL1310110019#
is: SBO:0000185

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR IMPC
is described by: ECO:0000269
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: IMP cyclohydrolase
is version of: http://identifiers.org/ec-code/2.1.2.3
reactant: MODEL1310110019#
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:

metaM uri e
is: C00299
initial amount: NaN
is: HMDB00296
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Uridine
is: CHEBI:16704

metaR SBT Dtde
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
name: D-sorbitol transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_40ef3592_464b_4624_98a0_9b203c414985
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:123041
initial concentration: NaN
name: SLC24A4

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 3mb2coa m
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: 3-methylbut-2-enoyl-CoA(4-)
is: SBO:0000247
is: HMDB01493
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
has only substance units: false
is: CHEBI:57344

http://identifiers.org/biomodels.db/MODEL1310110019#_11893deb_f0c1_43c5_8539_9e473b631b0c
type: Species
initial amount: NaN
initial concentration: NaN
name: GGT5
is: SBO:0000252
is: P36269
constant: false
is encoded by: hsa:2687
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_c3384c49_226f_4932_98a9_61937ef1db20
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2181
has only substance units: false
boundary condition: true
type: Species
is: B3KMA6
name: ACSL3

metaR r2375
type: Reaction
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaR r2122
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#

metaM hco3 e
name: Bicarbonate
initial concentration: 1.0
type: Species
is: CHEBI:17544
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
is: SBO:0000247
is: HMDB00595
constant: false
initial amount: NaN
has only substance units: false

metaM 3odcoa m
is: SBO:0000247
is: CHEBI:28528
is: HMDB03939
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
name: 3-Oxodecanoyl-CoA
initial amount: NaN
has only substance units: false

metaM methf m
is: CHEBI:57455
has only substance units: false
is: HMDB01354
initial amount: NaN
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_adda7a57_042a_42a5_b1c6_eeeb4773b807
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:79966
has only substance units: false
type: Species
initial amount: NaN
name: SCD5
is: Q86SK9

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
modifier: MODEL1310110019#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#

metaR r0236
is: SBO:0000176
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_41572d35_7055_48e7_85a2_acae8ac3face
name: _AI971036_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI971036
constant: false
is: SBO:0000252
boundary condition: true

metaM gchola e
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00138
name: glycocholate
type: Species

metaR r1900
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110019#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d69584f6_2306_45e1_983a_94901a171a73
initial amount: NaN
name: _AI697028_1_e
type: Species
has only substance units: false
is encoded by: hsa:AI697028
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR r2374
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM Sfglutth c
name: S-formylglutathionate(1-)
boundary condition: false
type: Species
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
initial concentration: 1.0
initial amount: NaN
is: HMDB01550
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9297e27f_586e_4ec0_9748_80600ae75e48
name: NOS1
type: Species
constant: false
is encoded by: hsa:4842
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: B4DG68
has only substance units: false

metaR GLNtm
is described by: ECO:0000000
reversible: false
name: L-glutamine transport via electroneutral transporter
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
kinetic law: MODEL1310110019#
fast: false

metaR NCKt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Na+/Ca2+-K+ exchange
type: Reaction
reactant: MODEL1310110019#
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110019#

metaM CE2434 m
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: CHEBI:57795
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0
constant: false

metaR RE3568C
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
name: RE3568
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
reversible: true

metaM CE2418 m
is: HMDB11123
initial concentration: 1.0
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
type: Species
is: CHEBI:28387
constant: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR CYTK5n
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
fast: false
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reactant: MODEL1310110019#

metaR PRO Dtde
reversible: true
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
name: D-proline transport, extracellular
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110019#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110019#_9cf9de95_f38d_4092_8fd0_0dae68145686
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AV717590
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AV717590_1_m

metaM mi4p D c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
name: 1D-myo-inositol 4-phosphate(2-)
is: HMDB01313
has only substance units: false
initial amount: NaN
is: CHEBI:58469
boundary condition: false
type: Species
is: SBO:0000247
constant: false

metaR r2373
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_5e63182f_b321_4f55_b14b_bd42cb723e91
is encoded by: hsa:53354
name: PANK1
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q8TE04
boundary condition: true
initial concentration: NaN
type: Species

metaR r2120
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e35a67d0_892b_4eee_9feb_22be0d78eb3d
has part: Q9NY65
name: EHHADH:ACAA1:ACOX1
initial amount: NaN
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:1962
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_f102a80c_be76_4316_ab05_de8d1be2c3bf
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC35A2
is encoded by: hsa:7355
is: P78381
has only substance units: false
boundary condition: true

metaM dmnoncoa c
has only substance units: false
is: HMDB11604
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA

metaR IMPD
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.205
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
fast: false
name: IMP dehydrogenase

metaR LACZe
name: b-galactosidase, extracellular
reversible: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.108
is described by: ECO:0000134
fast: false
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_791e5dd1_6f3a_463c_bda1_449b619cfc71
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: P51648
name: ALDH3A2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:224
type: Species

metaR r1088
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
name: Active transport
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8aba782e_ebf2_4329_9e2e_fcb75833ff53
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9H999
is: SBO:0000252
is encoded by: hsa:79646
constant: false
initial amount: NaN
name: PANK3

metaM phe L e
initial concentration: 1.0
is: SBO:0000247
name: L-phenylalanine
initial amount: NaN
is: HMDB00159
is: CHEBI:17295
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: NADH(2-)
boundary condition: false
is: CHEBI:57945
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_f3641b21_013e_4a86_97cf_956e11960ee4
is: Q7LG56
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50484
name: RRM2B
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM dpcoa e
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01373
is: CHEBI:57328
is: C00882
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
is: SBO:0000247
name: Dephospho-CoA
constant: false

metaR r0394
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_1adf13f0_0296_41b7_babd_cb022fc30724
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:217
is: P05091
name: ALDH2
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_55e518a6_a82b_41f7_b94a_a4ca9e315dd8
boundary condition: true
initial amount: NaN
is encoded by: hsa:3417
is: O75874
constant: false
name: IDH1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1665
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110019#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_87ffba5e_7a0a_4c21_ab8c_5f3872e9eda3
name: HSD3B7
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9H2F3
is encoded by: hsa:80270
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM gly c
name: Glycine
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
constant: false
is: C00037
initial amount: NaN
type: Species
is: CHEBI:3339
is: SBO:0000247

metaM acrn x
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
name: O-acetylcarnitine
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57589
type: Species

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
boundary condition: false
is: SBO:0000247
is: HMDB00161
is: CHEBI:16977
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM q10 c
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
is: CHEBI:46245
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01072
is: SBO:0000247

metaM gsn c
name: Guanosine
has only substance units: false
initial amount: NaN
is: HMDB00133
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16750
initial concentration: 1.0
type: Species
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_8718afa2_c2d7_4a52_b993_7f101d86ea73
has only substance units: false
name: CROT
is encoded by: hsa:54677
boundary condition: true
type: Species
initial concentration: NaN
is: E7EQF2
is: SBO:0000252
constant: false
initial amount: NaN

metaM pail34p hs c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: CHEBI:57658
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM retinol 9 cis c
has only substance units: false
constant: false
is: HMDB06217
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17336
name: 9-cis-retinol

metaR r2333
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM gdp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58189
is: C00035
has only substance units: false
name: GDP
constant: false

metaM acnam c
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:35418
is: HMDB00230
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false

metaM dgdp m
is: HMDB00960
has only substance units: false
constant: false
is: CHEBI:58595
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f9bdf110_ed28_414f_b5d4_f85f72b8bd13
name: VNN3:VNN2:VNN1
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: O95498
is encoded by: hsa:8875
is: SBO:0000297
is encoded by: hsa:55350
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_ca681524_7c6d_4abe_b15b_211f5757c1b2
initial concentration: NaN
name: PANK1
boundary condition: true
is: Q8TE04
is: SBO:0000252
constant: false
is encoded by: hsa:53354
type: Species
has only substance units: false
initial amount: NaN

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
modifier: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR PMEVKc
name: phosphomevalonate kinase, cytosol
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
reversible: false
product: MODEL1310110019#
fast: false
is described by: ECO:0000134

metaR r1664
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM asn L c
initial concentration: 1.0
is: CHEBI:17196
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
constant: false
name: L-asparagine

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
is: CHEBI:17490
is: HMDB00222
has only substance units: false
name: L-palmitoylcarnitine
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM dgsn c
has only substance units: false
is: C00330
boundary condition: false
is: HMDB00085
is: CHEBI:17172
is: SBO:0000247
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
name: Deoxyguanosine
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r0208
is version of: http://identifiers.org/ec-code/4.4.1.1
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaM dhap c
is: CHEBI:57642
boundary condition: false
is: C00111
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01473
name: Dihydroxyacetone phosphate
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411

metaR H2O2t
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110019#

metaR r2334
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110019#
reversible: true
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR NDPK4n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000304
kinetic law: MODEL1310110019#
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction

metaM pristcoa x
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false
initial amount: NaN
name: pristanoyl coa
is: CHEBI:51341
type: Species
initial concentration: 1.0

metaM dgdp n
type: Species
name: dGDP(2-)
is: CHEBI:58595
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00960
initial concentration: 1.0
initial amount: NaN

metaR DNDPt28m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dGDP antiport
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
reversible: false
product: MODEL1310110019#
is: SBO:0000185
type: Reaction

metaM Rtotal2 e
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
initial concentration: 1.0
is: C00255
is: CHEBI:3554
type: Species
has only substance units: false
name: R total 2 position
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM gly e
is: HMDB00123
initial concentration: 1.0
is: SBO:0000247
name: Glycine
initial amount: NaN
is: C00037
is: CHEBI:3339
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species

metaM dpcoa c
has only substance units: false
initial concentration: 1.0
name: Dephospho-CoA
initial amount: NaN
is: HMDB01373
is: C00882
is: SBO:0000247
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
is: CHEBI:57328
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_4c92fa96_a5aa_410b_9b52_5cc769923c49
is encoded by: hsa:171425
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: Q8N0X4
name: CLYBL
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_abeb80de_6f04_4efd_aa98_c45ed8319358
initial amount: NaN
name: _AA419122_1_c
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AA419122
has only substance units: false
constant: false

metaR r1667
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true

metaR r2335
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true
fast: false
product: MODEL1310110019#
type: Reaction

metaM gsn e
initial amount: NaN
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
is: SBO:0000247
name: Guanosine
constant: false
has only substance units: false
is: CHEBI:16750
type: Species
boundary condition: false
initial concentration: 1.0
is: C00387

metaM 3snpyr c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:1665
name: 3-Sulfinopyruvate
is: HMDB02332
type: Species
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
initial concentration: 1.0
boundary condition: false

metaM 2mbcoa m
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
type: Species
is: HMDB01041
is: SBO:0000247
is: CHEBI:57336
boundary condition: false
has only substance units: false
name: 2-methylbutanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110019#_aff78628_a8cf_4770_8d4b_74204734fa20
name: SLC16A1
initial amount: NaN
has only substance units: false
is: B4DKS0
initial concentration: NaN
is encoded by: hsa:6566
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR TRIODTHYt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
reactant: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110019#
name: T3 transport via facilitated diffusion
reversible: true
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3cc50829_8702_42dd_9918_faaef73c79d6
is: Q9NPB1
type: Species
is encoded by: hsa:56953
constant: false
initial amount: NaN
name: NT5M
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM asn L e
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
name: L-asparagine
type: Species
is: SBO:0000247
is: HMDB00168
is: CHEBI:17196
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_9d42a709_c38f_495c_a137_1bd31e6f211e
boundary condition: true
is: P27144
constant: false
name: AK4
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:205
type: Species

metaR MI3PP
type: Reaction
fast: false
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110019#
reversible: false
product: MODEL1310110019#
name: myo-inositol 3-phosphatase
reactant: MODEL1310110019#

metaR r1666
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
type: Reaction

metaM dgsn e
has only substance units: false
constant: false
type: Species
is: C00330
is: CHEBI:17172
name: Deoxyguanosine
is: HMDB00085
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM hdca c
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00220
is: SBO:0000247
is: CHEBI:7896
initial amount: NaN
type: Species
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM 44mctr r
is: SBO:0000247
is: CHEBI:17813
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
constant: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial concentration: 1.0
is: HMDB01023
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_51edf8de_28d2_49da_8ddc_ca9b02dc7d24
has only substance units: false
name: ATP10A
initial concentration: NaN
is encoded by: hsa:57194
is: O60312
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR GLUDym
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
is: SBO:0000176
name: glutamate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.1.3
reversible: true
product: MODEL1310110019#

metaM Rtotal2 c
is: C00055
initial concentration: 1.0
initial amount: NaN
name: R total 2 position
boundary condition: false
is: HMDB00095
constant: false
is: SBO:0000247
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: CHEBI:60377
type: Species

metaR PACCOAL
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110019#
name: phenylacetate-CoA ligase
reversible: false
type: Reaction

metaR r1998
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110019#

metaM 2mcit c
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
has only substance units: false
type: Species
constant: false
is: CHEBI:15598
is: HMDB00379
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 2-methylcitrate(3-)
is: SBO:0000247

metaR r1661
modifier: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
type: Reaction

metaR HISD
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.3.1.3
fast: false
name: histidase
modifier: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_19825b83_39be_4933_8e7b_5d64d1380dcc
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1716
type: Species
name: DGUOK
has only substance units: false
is: E5KSL6

metaM ca2 c
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00464
type: Species
is: CHEBI:29108
name: calcium(2+)
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_4b40f6e5_47bc_4d26_b860_0584e5cb7b40
boundary condition: true
initial concentration: NaN
is: Q8WXF9
is encoded by: hsa:66035
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC2A11
type: Species

metaM leuktrC4 c
name: leukotriene C4(2-)
boundary condition: false
initial concentration: 1.0
is: HMDB01198
type: Species
initial amount: NaN
is: CHEBI:57973
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
is: SBO:0000247

metaR ACHtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#

metaR CRNtx
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
name: carnitine transport peroxisome to mitochondria
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_f87680ae_6fd4_49d2_9ce4_52eebc3dd91b
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q92536
name: SLC7A6
has only substance units: false
type: Species
is encoded by: hsa:9057
initial concentration: NaN

metaR 2MCITt
name: 2-methylcitrate transport via diffusion
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
fast: false
reversible: true
is described by: ECO:0000000

metaR r0287
is: SBO:0000176
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#

metaR r1660
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_47ce74c2_c1aa_4152_a0e2_0d8d46f7464f
boundary condition: true
initial amount: NaN
is encoded by: hsa:204
initial concentration: NaN
type: Species
has only substance units: false
name: AK2
is: SBO:0000252
constant: false

metaM nadh x
is: C00004
is: HMDB01487
is: SBO:0000247
constant: false
is: CHEBI:57945
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306

metaM HC01401 m
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:27668
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false

metaR r2330
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_cd12f746_c9c7_41eb_96a6_ce652fb9f680
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9P019
initial concentration: NaN
is encoded by: hsa:29085
type: Species
boundary condition: true
name: PHPT1

metaM CE2250 e
is: CHEBI:52328
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
constant: false
boundary condition: false
initial amount: NaN
name: 3-oxodocosanoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_ab120c47_ff84_4b2a_a27c_7805c3dd707b
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O00400
boundary condition: true
is encoded by: hsa:9197
type: Species
constant: false
name: SLC33A1

metaR H2O2syn
fast: false
name: Hydrogen peroxide synthesis (NADPH dependent)
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.6.3.1
reactant: MODEL1310110019#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
is described by: ECO:0000304

metaM Rtotal c
is: SBO:0000247
is: CHEBI:16349
is: HMDB00904
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total

metaM ca2 e
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00464
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
initial amount: NaN
is: CHEBI:29108
is: SBO:0000247
constant: false

metaR MANt4
reversible: true
name: D-mannose transport via sodium cotransport
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_5061e6ad_4516_46d8_ba0e_973a259b788c
is encoded by: hsa:8704
is: O60909
type: Species
name: B4GALT2
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_deb40136_3f31_4cd7_a30e_68ffae60ce27
has only substance units: false
name: CHAT
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
is: Q6LEN6

metaR r1996
fast: false
reversible: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM 2mcit e
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
type: Species
constant: false
has only substance units: false
is: HMDB00379
is: CHEBI:15598
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 2-methylcitrate(3-)

metaR PEAMNO
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
is described by: ECO:0000304
product: MODEL1310110019#
type: Reaction
name: Phenethylamine oxidase
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176

metaR GK1
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110019#
name: guanylate kinase (GMP:ATP)
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_7c7f31a1_6cdb_4884_8c3e_dbfe3894beb3
constant: false
initial amount: NaN
is encoded by: hsa:80864
initial concentration: NaN
is: Q99944
is: SBO:0000252
name: EGFL8
type: Species
has only substance units: false
boundary condition: true

metaR r1783
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_df22048e_87cd_45cb_b50c_a9fc613f945c
is encoded by: hsa:10841
initial concentration: NaN
is: O95954
type: Species
boundary condition: true
name: FTCD
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d1b4b076_4d77_4888_ab65_4ddbb4abbde1
is encoded by: hsa:159
name: ADSS
constant: false
is: P30520
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d79384ac_9a4f_4da9_8b57_1f2a2f05492f
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:23169
has only substance units: false
boundary condition: true
is: Q9NTN3
name: SLC35D1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_60e1a44a_02d9_45fd_972d_3b229f28fc9d
name: PYCR1
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: A6NFM2
initial concentration: NaN
is encoded by: hsa:5831
boundary condition: true

metaR r2331
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_c85aa7cf_ae66_4b8d_b9f6_7a193a1e5fac
type: Species
name: CRAT
is: SBO:0000252
initial concentration: NaN
is: P43155
constant: false
is encoded by: hsa:1384
initial amount: NaN
boundary condition: true
has only substance units: false

metaM HC01115 c
is: CHEBI:29025
initial amount: NaN
constant: false
name: NeuNGc
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaM leuktrC4 e
boundary condition: false
is: CHEBI:57973
constant: false
name: leukotriene C4(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01198
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM acrn r
is: CHEBI:57589
name: O-acetylcarnitine
is: HMDB00201
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_f3cdc30e_4eae_4f64_8f27_b694d8bc251c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:29988
name: SLC2A8
is: Q9NY64
type: Species

metaR r0399
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
fast: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is described by: ECO:0000000
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_80498ced_3095_476c_98cc_075fcbbac81b
name: ADH5
is encoded by: hsa:128
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: Q6IRT1
initial concentration: NaN

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: RE2659
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000

metaR r1995
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110019#
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185

metaR r1662
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_29aefe6d_a873_4a41_a804_176b03f21f3b
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:353
initial concentration: NaN
boundary condition: true
is: P07741
name: APRT

metaM dhap e
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
initial amount: NaN
name: glycerone phosphate(2-)
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB01473
has only substance units: false

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3ecd5579_50f9_4697_bc3f_7a3179670da0
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI373818
initial amount: NaN
name: _AI373818_1_m
constant: false
boundary condition: true
type: Species

metaR NH4t3r
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
name: ammonia transport via proton antiport
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000269

metaM malttr e
is: CHEBI:27931
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C01835
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: maltotriose
is: HMDB01262

metaR DGSNtm
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
name: deoyguanosine transport in mitochondria
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_a04684a7_f7ce_470e_aaf6_bc7c77d370ed
type: Species
initial amount: NaN
is encoded by: hsa:2878
is: P22352
has only substance units: false
boundary condition: true
name: GPX3
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_3f1c73b6_3827_42b3_bbf0_6cc0f3a8ceba
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5333
initial amount: NaN
name: PLCD1
has only substance units: false
is: P51178
boundary condition: true

metaR RE3001M
fast: false
name: RE3001
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.1.34

metaM rbt c
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: D-ribitol
boundary condition: false
is: CHEBI:15963
is: HMDB00508
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_33d3b168_fe48_48fe_be99_1094413e45f0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI926493
name: _AI926493_1_m
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR r1552
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_c3c366b8_4ab2_4908_9e77_ba37b02688c9
type: Species
is encoded by: hsa:H77542
initial concentration: NaN
is: SBO:0000252
name: _H77542_1_r
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR r2083
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#

metaR MDHx
is described by: ECO:0000134
name: malate dehydrogenase, peroxisomal
kinetic law: MODEL1310110019#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_b7d3c4a7_c6df_4042_85bd_3670048441a9
has only substance units: false
is encoded by: hsa:2618
initial concentration: NaN
type: Species
name: GART
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q59HH3

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_a2ba50d5_b336_49a1_aff8_1412694794a9
is: Q5VSR7
boundary condition: true
is encoded by: hsa:5214
initial concentration: NaN
constant: false
initial amount: NaN
name: PFKP
is: SBO:0000252
type: Species
has only substance units: false

metaR C3STKR2r
name: C-3 sterol keto reductase (zymosterol)
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
product: MODEL1310110019#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reversible: false
modifier: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_322b9273_f469_415e_8f6c_1e098547bc41
name: PCK1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5105
initial concentration: NaN
is: P35558
type: Species
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ef1bc273_5ac7_4ea1_be52_8d6c77df7a82
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: HMGCS2
is encoded by: hsa:3158
has only substance units: false
is: P54868
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_86960350_dfbb_46d0_8d9e_f85f2c8a447f
is: Q16718
initial concentration: NaN
is encoded by: hsa:4698
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: NDUFA5
boundary condition: true
is: SBO:0000252

metaR r2085
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_2be890e3_7385_42cb_95c2_f63509e4e91d
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: ALDH3A2
has only substance units: false
is: P51648
boundary condition: true
is encoded by: hsa:224
initial amount: NaN

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
reversible: true
type: Reaction
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000304
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR r1891
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#

metaR r2084
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_1bb23d19_8a94_4084_b17a_be1746e245a1
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q16881
is encoded by: hsa:7296
name: TXNRD1
constant: false
has only substance units: false

metaR r1551
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#

metaR r0178
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reversible: true
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b2410b1d_1ae4_417f_9423_2ddda336217e
name: NT5C3
has only substance units: false
initial amount: NaN
is: Q9H0P0
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:51251
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_810dc8c6_d3c7_46d8_bf39_6f3c9a39e68f
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:953
constant: false
is: Q86VV3
boundary condition: true
name: ENTPD1
initial concentration: NaN

metaM 34dhmald c
name: 3,4-Dihydroxymandelaldehyde
type: Species
is: C05577
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

metaR HSD3A1r
reversible: true
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110019#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110019#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110019#
fast: false

metaM nrpphr c
has only substance units: false
is: CHEBI:33569
constant: false
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
boundary condition: false
is: HMDB00216
name: Norepinephrine
is: SBO:0000247
initial amount: NaN

metaM xylu L c
has only substance units: false
name: L-xylulose
boundary condition: false
is: CHEBI:17399
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB00751
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267

metaM gdp m
is: CHEBI:58189
is: SBO:0000247
is: C00035
is: HMDB01201
boundary condition: false
has only substance units: false
constant: false
name: GDP
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

metaR CSNATer
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is described by: ECO:0000254
name: carnitine O-acetyltransferase, endolasmic reticulum

metaM rbt e
is: HMDB00508
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_27218247_ac1e_401e_b080_43fc3ad92853
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4645
name: MYO5B
type: Species
initial concentration: NaN
boundary condition: true
is: Q9H6Y6
constant: false

metaM ru5p D c
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
type: Species
constant: false
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01232
name: 4-nitrophenolate
constant: false
is: CHEBI:57917
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR LEUKTRB4t
name: leukotriene B4 transport
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110019#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
reversible: true
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR TSULt4 3
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
reversible: true
name: thiosulfate transport via sodium symport
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
kinetic law: MODEL1310110019#

metaR MTHGXLt
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
product: MODEL1310110019#
name: Methylglyoxal transport (cytosol to extracellular)

metaM hmgcoa x
constant: false
is: CHEBI:15467
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
initial amount: NaN
type: Species

metaR ATPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
reactant: MODEL1310110019#
name: ATP transporter, peroxisomal
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
fast: false

metaR PLA2 2
kinetic law: MODEL1310110019#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110019#
name: phospholipase A2
reversible: false
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
is described by: ECO:0000000

metaM CE5119 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57923
initial amount: NaN
constant: false
is: SBO:0000247
name: trans-3-cis-8-tetradecadienoyl-CoA
initial concentration: 1.0

metaR r1554
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_d1bcb9fb_b803_42b1_95c1_b15e053cb306
boundary condition: true
is encoded by: hsa:H53099
is: SBO:0000252
name: _H53099_1_m
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_0a002f4a_4b14_40a2_b56f_cce06f7e418f
has only substance units: false
is: P11168
is: SBO:0000252
type: Species
name: SLC2A2
is encoded by: hsa:6514
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_7bd52855_b39a_4d8a_93e1_135f35596b3b
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFA13
is encoded by: hsa:51079
is: Q9P0J0
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_33a4af99_b430_4213_af0f_9b36833c6dc3
is: SBO:0000252
boundary condition: true
is: Q16739
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: UGCG
is encoded by: hsa:7357

metaR r2406
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110019#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaM dpcoa m
constant: false
type: Species
is: CHEBI:57328
is: HMDB01373
is: SBO:0000247
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
boundary condition: false
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN

metaR RE1303C
reactant: MODEL1310110019#
type: Reaction
reversible: false
name: RE1303
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7937829 NOTES:

metaR r1553
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction

metaR r2082
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000

metaM dmpp x
name: prenyl diphosphate(3-)
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57623
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120
has only substance units: false
initial concentration: 1.0

metaR ME2
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.40
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000
name: malic enzyme (NADP)
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false

metaM dgsn m
is: C00330
is: SBO:0000247
boundary condition: false
is: HMDB00085
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
is: CHEBI:17172
name: Deoxyguanosine
type: Species
constant: false

metaR GMPR
modifier: MODEL1310110019#
name: GMP reductase
product: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.7.1.7
is described by: ECO:0000269
reactant: MODEL1310110019#

metaR L LACt2r
kinetic law: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
type: Reaction
reversible: true
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
name: L-lactate reversible transport via proton symport
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d1810e58_c631_42da_bb3b_660d3f3c2956
is: SBO:0000252
name: OGDH
type: Species
constant: false
initial concentration: NaN
is: B4E3E9
has only substance units: false
is encoded by: hsa:4967
boundary condition: true
initial amount: NaN

metaR r0437
reversible: true
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
modifier: MODEL1310110019#

metaM nrpphr e
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
name: Norepinephrine
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00216
is: SBO:0000247

metaM retinal cis 13 r
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:45487
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial concentration: 1.0
is: HMDB06220
name: 13-cis-retinal

metaR r2088
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185

metaM occoa m
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false
is: SBO:0000247
is: CHEBI:57386
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
initial concentration: 1.0
is: C01944
initial amount: NaN
constant: false
type: Species

metaR ACACT10m
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
type: Reaction
fast: false
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is: SBO:0000176

metaM 5adtststerones c
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
type: Species
boundary condition: false
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR DPCOAPPe
type: Reaction
name: Pyrophasphatase (dephospho-CoA, extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
fast: false

metaM ipdp x
constant: false
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial amount: NaN
is: SBO:0000247
name: isopentenyl diphosphate(3-)
is: CHEBI:128769
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01347

metaM hdca l
initial amount: NaN
constant: false
is: CHEBI:7896
is: SBO:0000247
is: HMDB00220
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
name: palmitate
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_dfc9f4ef_6c08_4305_bc3b_7e70c40d146e
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: _AW277253_1_c
initial concentration: NaN
is encoded by: hsa:AW277253
constant: false
has only substance units: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM na1 e
is: HMDB00588
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:4541
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
type: Species
name: Sodium
is: C01330
initial concentration: 1.0
boundary condition: false

metaR r1556
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_89e7f673_7cf7_4060_b7b4_9d87bbdc9e00
name: ALAD
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:210
constant: false
has only substance units: false
is: P13716
boundary condition: true
initial concentration: NaN

metaM maltpt e
is: C02052
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01296
constant: false
name: maltopentaose

metaM tchola e
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00036
name: taurocholic acid
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaM 3aib D m
name: D-3-Amino-isobutanoate
is: HMDB02299
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
boundary condition: false
constant: false
is: C03265

metaM fadh2 c
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01197
is: SBO:0000247
is: CHEBI:58307
has only substance units: false
initial concentration: 1.0
name: FADH2(2-)
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f6ac3088_694a_4917_aa31_c423cb3883e0
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: SLC13A4
is encoded by: hsa:26266
is: Q9UKG4
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_8dfaa81b_1f72_47ea_b228_d68f1e2569cc
is encoded by: hsa:217
is: P05091
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: ALDH2

metaM tchola c
is: CHEBI:36257
constant: false
name: taurocholic acid
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_cfeab295_1de9_4228_a551_38cc2e218a54
type: Species
is: Q9BY49
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: PECR
is: SBO:0000252
is encoded by: hsa:55825

metaR r2089
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110019#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110019#_8941d353_8b89_4e78_87dc_4b424b9ee466
initial concentration: NaN
name: ACO1
initial amount: NaN
is: SBO:0000252
is: P21399
is encoded by: hsa:48
has only substance units: false
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_0f753b48_d5be_4d8d_8b64_9e5a5bbb85e9
initial concentration: NaN
constant: false
name: SMPD3
is: Q9NY59
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:55512
is: SBO:0000252

metaR r2338
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
kinetic law: MODEL1310110019#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM gdp n
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: HMDB01201
has only substance units: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_b34aacb7_d8e5_4322_b7e7_10172e3b87a2
type: Species
name: SLC17A4
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10050
is: Q9Y2C5
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d4d8a665_4685_49ff_9005_fd1274f93901
type: Species
name: DLST
is encoded by: hsa:1743
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P36957

http://identifiers.org/biomodels.db/MODEL1310110019#_c408ac1a_306f_4334_add2_364b68806db1
is: SBO:0000252
is encoded by: hsa:2653
type: Species
initial amount: NaN
name: GCSH
has only substance units: false
boundary condition: true
is: P23434
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_cdd49a88_3a25_45eb_98d1_24f15089960c
is encoded by: hsa:6582
constant: false
initial concentration: NaN
name: SLC22A2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM 2dr1p c
is: C00672
has only substance units: false
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
is: HMDB01351
boundary condition: false
is: CHEBI:58576
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaR r2086
is: SBO:0000185
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000

metaM lnlccoa c
name: linoleic coenzyme A
constant: false
has only substance units: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d1025d62_a324_4f32_b2d2_6dece1cd2c10
has only substance units: false
boundary condition: true
type: Species
name: SLC5A9
constant: false
is: E9PAK4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:200010
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_34f2c82a_53e9_4540_8627_7933088f8931
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:10682
type: Species
constant: false
name: EBP
initial concentration: NaN
is: Q15125
has only substance units: false

metaM na1 c
has only substance units: false
is: HMDB00588
is: CHEBI:4541
is: SBO:0000247
constant: false
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
name: Sodium
type: Species
is: C01330
initial concentration: 1.0
boundary condition: false

metaR BHBtm
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true

metaM dgdp c
type: Species
is: CHEBI:58595
initial amount: NaN
constant: false
boundary condition: false
name: dGDP
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
initial concentration: 1.0
is: HMDB00960

http://identifiers.org/biomodels.db/MODEL1310110019#_f5d1c1f2_e029_4e98_941d_c79caa21e8df
is: P27707
boundary condition: true
name: DCK
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1633
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_88afd496_429c_4a3b_992e_21c2a88ea05f
initial concentration: NaN
type: Species
is encoded by: hsa:8704
boundary condition: true
is: SBO:0000252
name: B4GALT2
initial amount: NaN
has only substance units: false
constant: false

metaR r1896
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0d36468b_8397_47a3_b6d0_f4298b37856e
is encoded by: hsa:6520
constant: false
is: SBO:0000297
has part: P08195
type: Species
initial concentration: NaN
name: SLC7A10:SLC3A2
has part: Q9NS82
has only substance units: false
boundary condition: true
is encoded by: hsa:56301
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e4798345_7f6c_4e49_8197_fa5464d0f198
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR r0179
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
modifier: MODEL1310110019#

metaR GLXtp
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
name: glyoxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM bhb c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
is: CHEBI:10983
is: HMDB00011
has only substance units: false
name: (R)-3-hydroxybutyrate
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2b8dc579_5351_4508_b885_68ee450dc071
is encoded by: hsa:NOS2A
name: _NOS2A_1_e
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2087
fast: false
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000

metaM HC01609 e
initial amount: NaN
name: UroporphyrinogenI
type: Species
is: CHEBI:28766
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR PRISTCOAtx
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
is: SBO:0000185
type: Reaction

metaR RE3628M
modifier: MODEL1310110019#
name: RE3628
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction

metaR URATEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110019#
name: urate export from cytosol
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction

metaM CE2838 e
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: SBO:0000247
is: C01936
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: maltononaose

http://identifiers.org/biomodels.db/MODEL1310110019#_d5ab4745_6db1_476f_b571_da6f14d820bf
is: Q13057
name: COASY
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:80347
initial concentration: NaN

metaM b2coa m
is: CHEBI:57332
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
boundary condition: false
type: Species
name: crotonoyl-CoA(4-)
has only substance units: false
is: HMDB02009
is: SBO:0000247

metaR r1557
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false

metaR 5AOPtm
product: MODEL1310110019#
fast: false
name: 5-Aminolevulinate mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
is described by: ECO:0000134

metaR RE0915E
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
name: RE0915
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110019#
type: Reaction
is: SBO:0000176

metaR SMPD3g
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000304
product: MODEL1310110019#
type: Reaction
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
reversible: false
reactant: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.4.12

metaM 3ohdcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: SBO:0000247
is: CHEBI:57349
constant: false
type: Species
initial amount: NaN

metaR r0812
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110019#

metaM bilirub c
constant: false
initial concentration: 1.0
name: bilirubin(2-)
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
is: CHEBI:57977
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR DPCOAK
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110019#
name: dephospho-CoA kinase
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: false
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_7eb98327_3dc5_40dc_8484_38f6780c047a
is: P23378
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:2731
initial amount: NaN
name: GLDC
initial concentration: NaN
is: SBO:0000252
type: Species

metaM pep m
type: Species
initial amount: NaN
is: HMDB00263
is: C00074
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
is: CHEBI:18021
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_c148451d_9c8f_4233_af5d_9a2a31742618
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: P30038
type: Species
name: ALDH4A1
is encoded by: hsa:8659
is: SBO:0000252
boundary condition: true

metaR r0642
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR 5MTHFt
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_96638ef7_e2d4_4c66_9744_f4a751b8d026
is encoded by: hsa:AA081045
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AA081045_1_e

metaR r1559
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110019#_8ef25c6a_b2f9_4c5f_808d_3146a27fb0b7
type: Species
initial concentration: NaN
is encoded by: hsa:8034
boundary condition: true
is: P16260
initial amount: NaN
name: SLC25A16
has only substance units: false
constant: false
is: SBO:0000252

metaR GLUPRT
kinetic law: MODEL1310110019#
fast: false
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_c458ccbc_b8bb_45ef_9ee6_2b2073445b7b
type: Species
has only substance units: false
is: P09622
name: DLD
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1738
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_d458bd62_1c3f_4244_b289_90229cf997c9
is encoded by: hsa:U52111
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: _U52111_1_c
type: Species
initial concentration: NaN

metaR LPCHOLt
product: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185
name: lysophosphatidylcholine transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_486fc835_49cd_4027_aa2f_2c1692d946db
is encoded by: hsa:10400
name: PEMT
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM nadh c
type: Species
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
is: SBO:0000247
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
is: CHEBI:57945
constant: false
initial concentration: 1.0

metaR r0181
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110019#
product: MODEL1310110019#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_c14018ab_e264_44fc_9e86_21df4431c384
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8560
name: DEGS1
constant: false

metaR AICART
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
fast: false

metaR PETOHMr hs
fast: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
reversible: false
kinetic law: MODEL1310110019#
is described by: ECO:0000254
is: SBO:0000176
name: phosphatidylethanolamine N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.17
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_c027875b_0ddc_4c6d_a20d_93b24c673b19
type: Species
name: ACSS3
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q9H6R3
is encoded by: hsa:79611

http://identifiers.org/biomodels.db/MODEL1310110019#_608af9c8_03c1_465c_9361_2d25aa02a34d
is encoded by: hsa:8776
type: Species
boundary condition: true
is: SBO:0000252
name: MTMR1
has only substance units: false
is: Q13613
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_2891fbe8_d6cd_4aa9_a116_cdb87081ba7b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI761708
constant: false
initial concentration: NaN
initial amount: NaN
name: _AI761708_1_m
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_50dc7abb_2a97_4be7_a59d_3298497e0c8c
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6241
constant: false
name: RRM2
is: P31350
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_98e62a1a_8922_4937_81d5_6a618b026343
is: P36021
is: SBO:0000252
initial concentration: NaN
name: SLC16A2
has only substance units: false
type: Species
is encoded by: hsa:6567
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_2ef4cac7_6fa8_4786_ba27_64bf526c827a
is encoded by: hsa:T83654
is: SBO:0000252
type: Species
name: _T83654_1_m
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM ura c
has only substance units: false
is: CHEBI:17568
is: SBO:0000247
initial concentration: 1.0
is: HMDB00300
boundary condition: false
initial amount: NaN
is: C00106
name: Uracil
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_dd20ea0d_6f8e_4c17_a9d6_180028ca424a
type: Species
boundary condition: true
is encoded by: hsa:AI440329
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI440329_1_r

metaR PPItm
is described by: ECO:0000134
name: diphopshate transporter, mitochondrial
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185

metaR H2CO3D
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is: SBO:0000176
modifier: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110019#
name: carboxylic acid dissociation

http://identifiers.org/biomodels.db/MODEL1310110019#_3866065a_d8c7_4596_ad2a_d43e2d4b66c6
initial concentration: NaN
is encoded by: hsa:587
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O15382
constant: false
name: BCAT2

metaM acald e
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: acetaldehyde
is: CHEBI:15343
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_d6c5f246_db61_4afa_8a0b_894e03272c7d
is: SBO:0000252
is encoded by: hsa:BF195998
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _BF195998_1_x
type: Species
has only substance units: false
constant: false

metaR SUCCtp
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110019#
type: Reaction
name: succinate transporter, peroxisome
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_37dd3ac0_50d1_4442_9ca7_e56bb1ab10d8
initial concentration: NaN
initial amount: NaN
name: EHHADH:ACAA1:ACOX1
is: SBO:0000297
constant: false
type: Species
has only substance units: false
is encoded by: hsa:51
boundary condition: true
has part: Q15067

http://identifiers.org/biomodels.db/MODEL1310110019#_a63ba35b_7425_4e8e_a11a_050ba10370e6
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: _100287639_1_c
is encoded by: hsa:100287639

metaR IPDPtx
is: SBO:0000185
type: Reaction
fast: false
name: Isopentenyl diphosphate transport (peroxisome)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
is described by: ECO:0000134
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR LTA4H
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.3.2.6
reversible: false
is: SBO:0000176
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction

metaM damp c
is: CHEBI:58245
is: SBO:0000247
is: HMDB00905
has only substance units: false
name: dAMP(2-)
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_982e317e_81bf_4492_b25b_3bea7dae1bfc
name: UGP2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7360
is: SBO:0000252
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2f354cc8_7fc0_4545_b780_beed6a7ab114
constant: false
is encoded by: hsa:U37519
type: Species
has only substance units: false
boundary condition: true
name: _U37519_1_e
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM CE5132 n
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
constant: false

metaR r0641
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000176
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110019#_437c6906_4e90_4d51_aaf5_93dd91249654
boundary condition: true
type: Species
is: Q9HBU6
is encoded by: hsa:55500
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: ETNK1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_4be77741_90e6_4fd6_acc8_edc2424c4866
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: HK1
is encoded by: hsa:3098
is: SBO:0000252
initial concentration: NaN
is: A8K7J7

metaM gam6p c
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
type: Species
is: SBO:0000247
is: HMDB01254
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
initial amount: NaN
has only substance units: false

metaR CYSGLTH
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is described by: ECO:0000000
name: Glutathione:cystine oxidoreductase

metaM fe3 c
constant: false
type: Species
initial amount: NaN
name: Fe3+
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3

http://identifiers.org/biomodels.db/MODEL1310110019#_5aef9915_19f6_4c78_92cb_c49e97ef7f42
initial amount: NaN
name: GCDH
constant: false
is: Q92947
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2639
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_85a018dc_fe7e_4f2e_b1d9_6dfd1884ba77
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI091231_1_c
is encoded by: hsa:AI091231
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM HC01407 m
is: SBO:0000247
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28276
type: Species
has only substance units: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268

http://identifiers.org/biomodels.db/MODEL1310110019#_69541daa_4dc0_47ab_987f_1d316152bb4f
initial concentration: NaN
initial amount: NaN
is: E9KL44
is encoded by: hsa:3030
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: HADHA

metaM hdca r
initial concentration: 1.0
is: CHEBI:7896
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
constant: false
name: Hexadecanoate (n-C16:0)
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00249
type: Species

metaM C05965 e
is: HMDB04243
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
is: CHEBI:57444
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 12(S)-HPETE(1-)

metaM 5adtststerones e
boundary condition: false
is: HMDB06278
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0

metaR 41R2A1H12BOOX
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR TYRCBOX
reversible: false
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
name: L-Tyrosine carboxy-lyase

metaR MANt1r
reversible: true
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
product: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d60c859b_a583_42e0_8e77_1b6c161654d1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: P32321
constant: false
name: DCTD
initial concentration: NaN
is encoded by: hsa:1635
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_1003c9a5_e1e5_44fe_9a82_a0058bf2cca2
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5320
is: SBO:0000252
type: Species
name: PLA2G2A
is: P14555

metaR r0186
is described by: ECO:0000000
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

http://identifiers.org/biomodels.db/MODEL1310110019#_99048d7c_147d_44ea_92f4_74adb2a8f60b
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10327
has only substance units: false
initial concentration: NaN
name: AKR1A1
boundary condition: true

metaM HC00229 e
name: Isomaltose
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false
has only substance units: false
is: CHEBI:28189
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_5671295d_63dc_4a30_9394_609f71868927
type: Species
is encoded by: hsa:286297
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: _286297_1_c
constant: false
is: SBO:0000252

metaM acald c
is: SBO:0000247
is: HMDB00990
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
constant: false
name: acetaldehyde
is: CHEBI:15343
initial concentration: 1.0
type: Species
has only substance units: false

metaR r2080
fast: false
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM dump n
is: SBO:0000247
initial amount: NaN
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:246422
type: Species
is: HMDB01409

http://identifiers.org/biomodels.db/MODEL1310110019#_dfc8b57e_46b7_4812_95d8_43da4d575d75
is: Q96CA6
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:30
is: SBO:0000252
boundary condition: true
name: ACAA1
initial amount: NaN
type: Species

metaM gdpmann c
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: HMDB01163

http://identifiers.org/biomodels.db/MODEL1310110019#_2907f625_cf6f_470a_aaad_37c43473bcee
is encoded by: hsa:221
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALDH3B1
has only substance units: false
is: P43353
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_be940f57_40cc_4da4_ad7f_b822cf499aa8
is: Q6IBC4
type: Species
is: SBO:0000252
name: NDUFS6
is encoded by: hsa:4726
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR FRDPtcr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reactant: MODEL1310110019#
fast: false
reversible: true
kinetic law: MODEL1310110019#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000134

metaR RE0453N
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: RE0453

metaM 5adtststerone c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
is: SBO:0000247
type: Species
is: HMDB02961
boundary condition: false
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR GARFT
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110019#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110019#
product: MODEL1310110019#
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:

metaM dopa c
is: CHEBI:59905
name: dopaminium(1+)
type: Species
is: HMDB00073
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR PI3P3Pn
fast: false
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
reversible: false
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000

metaM ump r
boundary condition: false
is: CHEBI:57865
initial amount: NaN
type: Species
name: UMP
has only substance units: false
is: SBO:0000247
is: HMDB00288
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM fe3 e
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: Fe3+
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial amount: NaN
is: CHEBI:29034
has only substance units: false
is: HMDB12943

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM dcacoa m
type: Species
is: HMDB06404
is: CHEBI:61430
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN

metaM 6thf e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/169691
name: hexaglutamyl folate (THF)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false
has only substance units: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_06b32556_a9ec_41fe_a37e_9f0303840795
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q14542
name: SLC29A2
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3177

metaR SERDGLYexR
fast: false
name: D-Serine/Glycine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
type: Reaction

metaR r0644
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction

metaR r2497
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reversible: false
type: Reaction
product: MODEL1310110019#

metaM didp c
is: CHEBI:28823
constant: false
type: Species
name: dIDP
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_458ee9f2_2152_4870_8a22_0407e16c4f80
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4713
is: P17568
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFB7
initial concentration: NaN

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_a362da38_79db_47d9_a0c9_4cef9c20f994
boundary condition: true
initial concentration: NaN
name: SC5DL
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6309
is: Q6GTM5

metaR Q10H2e
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000134
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true
name: transport of ubiquinol into lymph
is: SBO:0000185
kinetic law: MODEL1310110019#

metaR TKT1
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: transketolase
product: MODEL1310110019#

metaR PSSA2 hs
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110019#
name: Phosphatidylserine synthase homo sapiens
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.8.29
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ

metaR RE1709C
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
name: RE1709

metaR PPAm
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#

metaM pristcoa c
name: pristanoyl coa
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false
has only substance units: false
is: CHEBI:51341
initial amount: NaN
boundary condition: false

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaR CYTK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: cytidylate kinase (CMP,CTP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_fb2925e0_fd1a_46fb_a141_14a188119a8a
is encoded by: hsa:1593
is: Q02318
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: CYP27A1
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR MALSO4tm
is described by: ECO:0000269
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: Malate:sulfate antiport, mitochondrial
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM ura e
type: Species
name: uracil
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00300

metaM 25hvitd3 e
is: CHEBI:17933
is: SBO:0000247
initial concentration: 1.0
name: calcidiol
constant: false
initial amount: NaN
is: HMDB03550
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

metaM 5adtststerone e
initial concentration: 1.0
is: CHEBI:16330
constant: false
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
is: HMDB02961
boundary condition: false
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN

metaM 4mzym int1 r
constant: false
type: Species
name: 4-Methylzymosterol intermediate 1
is: HMDB06927
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d1a0fde3_4d04_489a_96b8_f9a9c8e79e51
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1119
constant: false
type: Species
is: P35790
name: CHKA
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_2519cc14_ff75_4397_bfd0_5c6fc257b73f
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9962
name: SLC23A2
is: Q9UGH3
initial concentration: NaN
constant: false
boundary condition: true

metaM q10 m
has only substance units: false
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
is: HMDB01072
initial amount: NaN
is: CHEBI:46245
type: Species
is: SBO:0000247
name: ubiquinone-10
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3fa50f3d_ef84_49cd_a10c_ad28c88d9417
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r2001
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_97921148_1c80_41e6_95bf_4a697880203c
is encoded by: hsa:3030
constant: false
boundary condition: true
is: E9KL44
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HADHA

metaM prostgf2 c
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57404
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
boundary condition: false
name: prostaglandin F2alpha(1-)
type: Species
is: SBO:0000247

metaM msa m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
constant: false
initial amount: NaN
name: 3-oxopropanoate
boundary condition: false
type: Species
is: HMDB11111
is: CHEBI:33190

http://identifiers.org/biomodels.db/MODEL1310110019#_bab79ce6_5570_4106_a6ad_427c387f0897
type: Species
name: CHAT
initial concentration: NaN
is: Q6LEN5
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103

metaR FTHFL
name: Formate-tetrahydrofolate ligase
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
fast: false
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#

metaR TKT2
type: Reaction
name: transketolase
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reactant: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_d7f0cb50_13e6_4771_a224_17927c6c6066
name: GMPPB
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29925
has only substance units: false

metaM k c
has only substance units: false
name: potassium
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00586
is: SBO:0000247
is: C00238
boundary condition: false
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species

metaM HC01409 m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:27540
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Hexanoyl-CoA
boundary condition: false

metaR r1109
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
fast: false

metaM 25hvitd3 c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
name: calcidiol
is: HMDB03550
is: SBO:0000247
is: CHEBI:17933

metaM retinal cis 13 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
is: HMDB06220
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: 13-cis-retinal
initial amount: NaN
constant: false
is: CHEBI:45487

metaR DNDPt17m
reversible: false
name: dUDP transport via dCDP antiport
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110019#

metaR r0915
fast: false
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_38072db4_55fa_4e67_b9de_824da31f8683
name: INPP4B
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8821
is: O15327
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_9762f91f_6b28_4e61_8a3a_7d6e401840e5
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2544
name: _2544_1_c

metaR RE0453C
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110019#
name: RE0453
reactant: MODEL1310110019#

metaR r0295
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f677a79a_f112_434d_9f31_91ded88b4072
is encoded by: hsa:10599
name: SLCO1B1
initial concentration: NaN
type: Species
is: Q9Y6L6
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM malthx e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
type: Species
is: C01936
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false

metaR r1993
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e2b7baaa_bd12_4654_b658_324bed2a273e
is: Q8TCT0
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:64781
type: Species
initial concentration: NaN
constant: false
name: CERK

metaM prostgf2 e
type: Species
initial concentration: 1.0
is: CHEBI:57404
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: prostaglandin F2alpha(1-)
initial amount: NaN
is: HMDB01139

http://identifiers.org/biomodels.db/MODEL1310110019#_31bcd9e3_28e8_4ebe_aaa4_6937c68767f6
boundary condition: true
name: TMEM54
initial concentration: NaN
is encoded by: hsa:113452
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q969K7

metaM arg L e
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00517
name: L-argininium(1+)
is: CHEBI:32682
boundary condition: false
constant: false
type: Species

metaR 3HCO3 NAt
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000134
reactant: MODEL1310110019#
name: 3HCO3_NAt
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110019#

metaM Rtotal e
name: R total
is: SBO:0000247
has only substance units: false
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
is: C00255
is: CHEBI:3554
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00244

metaR r0321
fast: false
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is: SBO:0000176

metaM sphmyln hs g
name: sphingomyelin betaine
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c8bd0c20_8d82_4508_b049_94122585cc0e
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q16698
name: DECR1
is: SBO:0000252
is encoded by: hsa:1666
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f525bc87_75e3_4729_83f1_004aa5791758
has only substance units: false
is: B7Z3W8
type: Species
name: SLC6A9
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6536
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_481b5918_2162_4b41_a72f_59d1225ab0fd
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3938
is: P09848
type: Species
name: LCT

metaR r1051
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true
product: MODEL1310110019#
name: Vesicular transport
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM acald m
type: Species
initial amount: NaN
is: HMDB00990
is: CHEBI:15343
is: SBO:0000247
name: acetaldehyde
has only substance units: false
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
constant: false

metaR GBA
is version of: http://identifiers.org/ec-code/3.2.1.45
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
fast: false
reversible: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
name: Glucosylceramidase

metaR RE2999M
reversible: true
is: SBO:0000176
name: RE2999
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaR r0917
kinetic law: MODEL1310110019#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110019#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_206c1d4f_eb16_4749_933c_251058c0863b
initial concentration: NaN
name: GGT2
is encoded by: hsa:728441
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_40187a35_ea62_4362_8e65_6890cc1e79fe
initial concentration: NaN
type: Species
name: MCCC1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:56922
is: Q96RQ3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c231657e_ab8e_4853_a6a2_1e31e76bbcff
is: SBO:0000252
initial amount: NaN
is: Q9Y345
is encoded by: hsa:9152
name: SLC6A5
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaM ipdp c
is: HMDB01347
initial amount: NaN
initial concentration: 1.0
name: Isopentenyl diphosphate
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:128769
is: C00129
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d23ce05b_fc00_4d52_8776_4045a7668cd0
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: RBAK
is encoded by: hsa:57786
is: Q9NYW8
has only substance units: false
constant: false

metaR HXPRT
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reactant: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
reversible: false

metaR r1050
name: Vesicular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d861c9cd_e030_42dc_ab05_b25f5bfe4028
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: SLC6A12
is: P48065
initial concentration: NaN
is encoded by: hsa:6539
has only substance units: false
is: SBO:0000252

metaR r0202
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
product: MODEL1310110019#

metaM nadh m
initial amount: NaN
boundary condition: false
type: Species
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: CHEBI:57945
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
is: SBO:0000247

metaM etoh e
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: ethanol
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108
initial amount: NaN
is: CHEBI:16236

metaR ALDD2xm
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is: SBO:0000176

metaR DOPAt4 2 r
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)

http://identifiers.org/biomodels.db/MODEL1310110019#_047ccba5_f859_40c6_a1fb_844c6f4032e0
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3145
is: P08397
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: HMBS

http://identifiers.org/biomodels.db/MODEL1310110019#_1fc92cca_f677_4762_a21e_c6d3a06fe2d1
is: SBO:0000252
name: KL
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:9365
type: Species
has only substance units: false
is: Q9UEF7

http://identifiers.org/biomodels.db/MODEL1310110019#_45bcd6aa_80c1_45db_a859_23da00113b19
is: SBO:0000252
boundary condition: true
name: ACAA1
type: Species
is encoded by: hsa:30
initial amount: NaN
constant: false
is: Q96CA6
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c88b574f_8279_4367_8833_5b8bd27e4607
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:314
name: AOC2
initial amount: NaN

metaM gly m
is: HMDB00123
initial concentration: 1.0
is: C00037
initial amount: NaN
is: SBO:0000247
is: CHEBI:15428
constant: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
type: Species
name: Glycine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e096ff81_a7db_460e_9b67_791367ef3db3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6646
initial concentration: NaN
is: B4DU95
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: SOAT1

metaM arg L c
type: Species
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00517
is: CHEBI:32682
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c4f2365b_007a_47cc_bfd7_edf4491be7d7
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110019#_74a31bc0_c397_409e_907f_85f45ce0e8b7
initial amount: NaN
is: SBO:0000252
name: PAICS
is encoded by: hsa:10606
constant: false
type: Species
boundary condition: true
is: P22234
has only substance units: false
initial concentration: NaN

metaR THYOXt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is: SBO:0000185
type: Reaction
name: T4 transport via facilitated diffusion
fast: false
product: MODEL1310110019#
is described by: ECO:0000269

metaR r1913
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f0c0303f_3376_4c1f_a5c5_3c0f2aca9894
initial amount: NaN
constant: false
is encoded by: hsa:5320
is: P14555
initial concentration: NaN
boundary condition: true
type: Species
name: PLA2G2A
has only substance units: false
is: SBO:0000252

metaM dhap x
is: http://identifiers.org/pubchem.compound/3411
is: C00111
is: CHEBI:57642
initial concentration: 1.0
is: SBO:0000247
is: HMDB01473
name: Dihydroxyacetone phosphate
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR PROD2m
name: Proline dehydrogenase (m)
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000254
reversible: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
reactant: MODEL1310110019#

metaM HC01603 c
is: CHEBI:57454
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: 10-Formyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110019#_c860b4e4_b401_4c64_aaae_22df393f4321
boundary condition: true
name: NDUFC1
type: Species
is encoded by: hsa:4717
is: O43677
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM HC00718 c
type: Species
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
has only substance units: false
is: CHEBI:57781
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_cc6dcfe2_9d66_4b05_9aa3_c8bca7dc3d40
is: Q9NY65
is: SBO:0000252
is encoded by: hsa:1962
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: EHHADH
has only substance units: false
constant: false

metaR r1668
type: Reaction
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_27878e15_b602_4a77_a670_289594621eeb
initial amount: NaN
name: SLC16A10
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q8TF71
constant: false
is encoded by: hsa:117247
has only substance units: false

metaM 3hibutcoa m
is: CHEBI:28259
initial amount: NaN
is: HMDB01052
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: (S)-3-Hydroxyisobutyryl-CoA

metaR ILEt5m
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
name: Isoleucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
is described by: ECO:0000000

metaR r0911
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
name: Facilitated diffusion
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaR ALASm
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: false
name: 5-aminolevulinate synthase
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110019#
type: Reaction

metaR RE1709N
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110019#
reversible: true
name: RE1709
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_3b88172d_9d58_4eed_b556_8565e89db9bc
initial concentration: NaN
constant: false
type: Species
is: Q9HCC0
has only substance units: false
boundary condition: true
name: MCCC2
initial amount: NaN
is encoded by: hsa:64087
is: SBO:0000252

metaR r1106
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110019#
name: Postulated transport reaction
fast: false

metaR DGCHOLte
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reversible: true
is described by: ECO:0000000

metaR LYStip
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
reversible: false
name: L-lysine transport, peroxisomal (irreversible)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2fc615f9_74f1_467f_8348_34d6b08904bb
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4708
is: SBO:0000252
is: H7C5B8
initial concentration: NaN
name: NDUFB2

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM etoh c
is: CHEBI:16236
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: ethanol
type: Species
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108
initial concentration: 1.0

metaR RE2954C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
modifier: MODEL1310110019#
name: RE2954
type: Reaction

metaR r1669
reactant: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110019#_980ba786_9bee_43ad_a4b5_c9ee89cb0132
name: SLC6A7
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: Q99884
is encoded by: hsa:6534

metaR LEUPHELAT2tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM focytC m
name: Ferrocytochrome C
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GLYt7 311 r
reversible: true
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
kinetic law: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#

metaM sphmyln hs c
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58216
is: SBO:0000247
name: sphingomyelin betaine
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007

metaR NDPK5n
product: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110019#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
fast: false
modifier: MODEL1310110019#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110019#

metaM na1 r
name: sodium(1+)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00588
is: CHEBI:29101
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN

metaR r0913
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_03222a8c_e108_4da0_8e79_a1d6bbe6ab64
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1375
name: CPT1B
is: Q53FV7
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM k e
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00586
name: potassium
is: CHEBI:29103
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00238

metaM acnam n
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
has only substance units: false
is: HMDB00230
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:35418

metaR ASCBt
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reactant: MODEL1310110019#
name: L-ascorbate transport via facilitated diffusion
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaR r1257
reactant: MODEL1310110019#
reversible: false
product: MODEL1310110019#
name: EC:6.2.1.3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000

metaM thp2c x
boundary condition: false
has only substance units: false
is: CHEBI:16987
is: SBO:0000247
initial concentration: 1.0
is: HMDB12130
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110019#_ee4b949b_39b4_43f2_8f0f_759d2b1b9fb4
name: ACO1
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: P21399
is encoded by: hsa:48
initial concentration: NaN

metaM nh4 x
is: CHEBI:28938
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Ammonium
type: Species
is: HMDB00051
has only substance units: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: C01342

http://identifiers.org/biomodels.db/MODEL1310110019#_9098984d_b7fa_4117_b87a_84bcf9f1f479
initial concentration: NaN
type: Species
is encoded by: hsa:4597
name: MVD
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P53602
constant: false
boundary condition: true

metaR PHYCBOXL
name: L-Phenylalanine carboxy-lyase
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000212
kinetic law: MODEL1310110019#
is: SBO:0000176

metaM q10 e
type: Species
constant: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
name: ubiquinone-10
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR CYANt
reactant: MODEL1310110019#
fast: false
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (extracellular to cytosol)
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_a316e740_7451_4cf3_a411_23ac7298e593
is: SBO:0000252
boundary condition: true
name: ALDH6A1
initial concentration: NaN
is: Q02252
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4329

metaM dump c
is: CHEBI:246422
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: dUMP
has only substance units: false
is: C00365

http://identifiers.org/biomodels.db/MODEL1310110019#_8cac9806_2134_42ff_bcf5_6445b72bd1c0
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:221
initial concentration: NaN
name: ALDH3B1
type: Species
is: P43353
boundary condition: true
has only substance units: false

metaM crn m
is: C00318
type: Species
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
initial concentration: 1.0
is: CHEBI:16347
initial amount: NaN
name: L-Carnitine
boundary condition: false
is: HMDB00062
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_29b31c62_423b_4697_bd66_48fdbedede72
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O14975
is encoded by: hsa:11001
name: SLC27A2
constant: false
initial amount: NaN

metaR GLYtm
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110019#
name: glycine passive transport to mitochondria

metaR SO4t4 2
is described by: ECO:0000269
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
is: SBO:0000185

metaM uppg3 c
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01086
is: C01051
name: Uroporphyrinogen III
is: CHEBI:57308
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051

metaM accoa c
is: HMDB01206
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57288
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
initial concentration: 1.0
name: Acetyl-CoA

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_10ee3614_1263_40b4_ace8_34e2d46e595a
name: OGDHL
is: Q9ULD0
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:55753

metaR r2347
is: SBO:0000185
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57453
is: HMDB01846
is: C00101
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate

metaM r5p c
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: alpha-D-Ribose 5-phosphate
has only substance units: false
is: C00117
initial amount: NaN
is: SBO:0000247
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: CHEBI:18189

metaM trp L e
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00929
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
initial amount: NaN
is: CHEBI:16828

metaR CYOR u10m
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110019#
reversible: false
is described by: ECO:0000134
name: ubiquinol-6 cytochrome c reductase, Complex III
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is: SBO:0000185
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110019#

metaM CE5118 m
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:57923
has only substance units: false

metaR r0093
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_5f27fec4_1a57_4de7_addd_63624a3ab804
boundary condition: true
initial concentration: NaN
name: ACAT1
initial amount: NaN
has only substance units: false
constant: false
is: P24752
type: Species
is encoded by: hsa:38
is: SBO:0000252

metaR r0998
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_ec7841ab_093e_42f1_96bb_28eb75dc186a
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_1cefff5f_a44b_4355_84c3_572e23ec511d
type: Species
boundary condition: true
constant: false
is: Q9H6Y6
is encoded by: hsa:4645
is: SBO:0000252
name: MYO5B
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_2c76d387_877b_4e22_ba5f_5b2f6f014d1a
name: IDI1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3422
type: Species
is: Q13907
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR r2079
reactant: MODEL1310110019#
fast: false
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110019#
reversible: true

metaR H2O2tp
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is described by: ECO:0000000
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_fc9b5665_a882_4690_9f6f_1cbf8aaf85b8
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:223
name: ALDH9A1
initial amount: NaN
type: Species
is: P49189
constant: false
initial concentration: NaN

metaR PEPCK
is described by: ECO:0000134
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d44f5e8a_1fe1_471a_b793_9081c230719c
is: E7EPT3
boundary condition: true
type: Species
is encoded by: hsa:501
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ALDH7A1

metaR NDPK3n
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b731e2cc_13f0_423a_b49e_c13818a83947
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6532
has only substance units: false
type: Species
initial amount: NaN
is: P31645
name: SLC6A4

http://identifiers.org/biomodels.db/MODEL1310110019#_e44a38e5_0e15_4b60_9b33_52e9aa2b587e
constant: false
boundary condition: true
is: Q9NY65
is encoded by: hsa:1962
type: Species
initial concentration: NaN
has only substance units: false
name: EHHADH
is: SBO:0000252
initial amount: NaN

metaM ump e
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
is: SBO:0000247
is: HMDB00288
name: UMP(2-)

metaM ficytC m
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:15991
name: Ferricytochrome c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123

http://identifiers.org/biomodels.db/MODEL1310110019#_1cc8f6e4_d207_4b18_ac07_e746c586d3fc
is: SBO:0000252
is encoded by: hsa:205
name: AK4
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR r0317
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d216c625_281d_4f57_b947_b8a3a0692881
is: SBO:0000252
is: O14561
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4706
boundary condition: true
name: NDUFAB1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_80560ee0_b908_4d17_9cd5_b2d4839f2525
is encoded by: hsa:1962
boundary condition: true
is: Q9NY65
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: EHHADH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_6b7be3c5_6adf_464e_a48e_ff7d006fc18e
is encoded by: hsa:641371
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: ACOT1
initial amount: NaN
is: E9KL42

metaR r0995
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction

metaM arachdcoa x
name: arachidonoyl-CoA(4-)
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06523
is: CHEBI:57368
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

http://identifiers.org/biomodels.db/MODEL1310110019#_1263c910_4295_4a6c_b165_037e31a0e399
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q9NPH0
is: SBO:0000252
initial amount: NaN
name: ACP6
is encoded by: hsa:51205

http://identifiers.org/biomodels.db/MODEL1310110019#_331e460c_211d_4b92_9e44_fa1be4ddafb3
initial amount: NaN
is: SBO:0000252
name: NDUFA2
has only substance units: false
type: Species
is: O43678
is encoded by: hsa:4695
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_6d0ddcdf_edfb_4b22_bce4_c84888f5641f
initial concentration: NaN
initial amount: NaN
is: P00568
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: AK1
is encoded by: hsa:203
type: Species

metaM trp L c
is: CHEBI:16828
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00929
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
constant: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM mag hs c
type: Species
is: SBO:0000247
is: CHEBI:16987
is: HMDB12130
constant: false
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_433e2272_4f35_4a4a_b15b_de5f9327c3a5
constant: false
has only substance units: false
is encoded by: hsa:5315
type: Species
is: SBO:0000252
name: PKM2
boundary condition: true
initial amount: NaN
is: P14618
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_0f503310_c1f2_4466_8b38_7c5749660998
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q6AI14
name: SLC9A4
is encoded by: hsa:389015

metaR r0002
reactant: MODEL1310110019#
type: Reaction
name: Active transport
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
fast: false
is: SBO:0000185
reversible: true

metaR r0541
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
reactant: MODEL1310110019#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_af4a1a2a_e378_47ad_87ec_2f027ba61660
type: Species
constant: false
name: RDH5
initial concentration: NaN
is encoded by: hsa:5959
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q92781

metaM met L c
is: HMDB00696
constant: false
boundary condition: false
is: SBO:0000247
name: L-methionine
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_df7b791b_1993_4d05_91a7_f5c2c3eb7b03
is: Q5MY95
boundary condition: true
name: ENTPD8
is encoded by: hsa:377841
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR GLYtp
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: glycine passive transport to peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
reversible: true
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
fast: false

metaR GTHO
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254
type: Reaction
name: glutathione oxidoreductase
product: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_821aea8c_69b9_457b_82c7_81270387096d
is: P19440
boundary condition: true
initial concentration: NaN
name: GGT1
type: Species
is encoded by: hsa:2678
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR CYSGLYexR
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
fast: false
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000185
name: L-cysteine/glycine reversible exchanger
reversible: true

metaR GLUDxm
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
name: glutamate dehydrogenase (NAD) (mitochondrial)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_2d38cdb5_9804_476b_937f_cc98e8b5fda3
constant: false
is: SBO:0000252
name: SYNJ1
has only substance units: false
boundary condition: true
is: O43426
type: Species
initial concentration: NaN
is encoded by: hsa:8867
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_1a84a36f_b996_40ba_80a6_f61b2988ebbf
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA977580
initial amount: NaN
initial concentration: NaN
type: Species
name: _AA977580_1_c

metaR r2139
product: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ump g
name: UMP(2-)
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00288
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110019#_f4abdd7f_a398_4779_acce_e2d5058288fc
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:23428
is: SBO:0000297
name: SLC7A8:SLC3A2
initial concentration: NaN
has part: Q9UHI5
has only substance units: false

metaR r2346
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110019#
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185

metaR UPPDC1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.37

metaM betald m
is: HMDB01252
is: CHEBI:15710
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
initial amount: NaN

metaR r1562
fast: false
type: Reaction
reactant: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_37ec99db_e5e6_4f9f_b363_1d80a4a4e156
constant: false
initial concentration: NaN
is: SBO:0000252
is: P15954
name: COX7C
is encoded by: hsa:1350
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaM mag hs e
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:60479
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: monoacylglycerol 2
constant: false

metaR SRTNt6 2 r
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110019#_3d85fca3_4261_4d61_a1da_ab3f0a8d04a2
has only substance units: false
constant: false
is encoded by: hsa:R33828
initial concentration: NaN
is: SBO:0000252
type: Species
name: _R33828_1_c
initial amount: NaN
boundary condition: true

metaM HC01444 e
constant: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
name: Galactosylglycerol
is: SBO:0000247
initial amount: NaN
is: CHEBI:15754
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

metaM crn r
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (R)-carnitine
has only substance units: false
boundary condition: false
is: HMDB00062

metaR r1561
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
product: MODEL1310110019#

metaR PRO1xm
is described by: ECO:0000254
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
name: proline oxidase (NAD), mitochondrial

metaR r0994
reactant: MODEL1310110019#
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
fast: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM 13dpg c
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: http://identifiers.org/pubchem.compound/3535
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01270
is: C00236
has only substance units: false
is: CHEBI:57604
name: 3-Phospho-D-glyceroyl phosphate

metaM ddcacoa m
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB03571
is: C01832
is: SBO:0000247
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_b25b2647_afb6_4257_bd0e_a350a6fe7e20
is: Q16795
is encoded by: hsa:4704
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: NDUFA9

metaR r2137
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110019#

metaR r0009
type: Reaction
modifier: MODEL1310110019#
fast: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_bbf27c85_a175_4b1e_bf3e_85ff13cd5c7b
constant: false
has only substance units: false
type: Species
name: PANK2
boundary condition: true
is encoded by: hsa:80025
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR C3STDH1r
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170

metaM 25aics c
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58443
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
boundary condition: false
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: C04823
initial amount: NaN
is: HMDB00797
initial concentration: 1.0

metaR RETNt
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
fast: false
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
kinetic law: MODEL1310110019#

metaR r2344
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: true
product: MODEL1310110019#

metaR r1560
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#

metaR O2Stm
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
name: superoxide anion transport via diffusion (mitochondria)
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_1861be44_9c51_4a1c_905c_d27920a8e32c
type: Species
name: INPP1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3628
initial concentration: NaN
is: SBO:0000252
is: P49441
initial amount: NaN

metaM nh4 m
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
has only substance units: false
is: C01342
is: HMDB00051
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110019#_f863ba0b_c617_4da2_a129_456bd5559b8c
name: PFKL:PFKP
is: SBO:0000297
initial concentration: NaN
has part: Q7L2M7
initial amount: NaN
is encoded by: hsa:5211
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_bbf13736_687f_4bdf_90ae_986db5db492d
constant: false
is: O14986
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIP5K1B
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8395
type: Species

metaM HC01415 m
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27537
type: Species
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_29cf7c8e_2751_4675_b12b_615e00aeddfb
is encoded by: hsa:22305
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: _22305_1_c
is: SBO:0000252
initial concentration: NaN

metaR RE1534M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110019#
name: RE1534
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reversible: true

metaM 2mop m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
name: 2-methyl-3-oxopropanoate
type: Species
constant: false
is: CHEBI:57700
has only substance units: false
is: HMDB01172
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_74afd9e9_7c20_4055_b739_5d351d1412b8
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:H45672
initial concentration: NaN
name: _H45672_1_m
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_8bd25764_0859_47a6_a6ec_7c4ed38e5f5b
is encoded by: hsa:57468
initial concentration: NaN
type: Species
boundary condition: true
name: SLC12A5
initial amount: NaN
is: Q9H2X9
has only substance units: false
is: SBO:0000252
constant: false

metaR r2341
reversible: true
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaR r2136
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

metaM cl e
is: C00115
type: Species
name: Chloride
initial amount: NaN
is: HMDB00492
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3966

metaM succ c
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
boundary condition: false
is: C00042
has only substance units: false
name: Succinate
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB00254
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c5879653_c249_41f3_abce_3d9ff3209705
is: SBO:0000252
constant: false
is encoded by: hsa:3990
boundary condition: true
name: LIPC
initial concentration: NaN
type: Species
initial amount: NaN
is: A6H8L5
has only substance units: false

metaM 3hmp m
type: Species
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00023
boundary condition: false
name: 3-hydroxy-2-methylpropanoate

metaM nh4 n
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: ammonium
is: CHEBI:28938
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
is: CHEBI:16236
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00108
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_a810fc7b_1ffd_43cb_b1f1_dd1cbc7441eb
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q16831
is encoded by: hsa:7378
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: UPP1

http://identifiers.org/biomodels.db/MODEL1310110019#_f59a8c8f_d6e2_4d89_9453_2b5bafe32cc5
is: SBO:0000252
name: TPI1
is encoded by: hsa:7167
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q53HE2
boundary condition: true
initial concentration: NaN

metaM ump c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: C00105
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
boundary condition: false
initial amount: NaN
is: HMDB00288
name: UMP

http://identifiers.org/biomodels.db/MODEL1310110019#_92a736de_72c6_444e_9de3_8bcf9809d43f
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:84812
is: Q9BRC7
type: Species
name: PLCD4
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_cd17ddeb_b9d0_451f_8a12_ac8d3dae2b41
type: Species
constant: false
is encoded by: hsa:AL048840
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AL048840_1_c

metaM nh4 c
is: HMDB00051
is: SBO:0000247
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:28938
is: C01342
initial amount: NaN
name: Ammonium
type: Species

metaM thp2c c
constant: false
initial amount: NaN
type: Species
name: 1-piperideine-6-carboxylate
is: SBO:0000247
has only substance units: false
is: CHEBI:16987
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
is: HMDB12130

http://identifiers.org/biomodels.db/MODEL1310110019#_5d4a4274_cc3b_4e60_818f_5842b194a5fd
has only substance units: false
initial amount: NaN
constant: false
is: P27987
is encoded by: hsa:3707
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ITPKB

metaR ACONTm
reversible: true
name: Aconitate hydratase
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical

metaR DCYTDn
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
name: deoxycytidine deaminase, nuclear
reversible: false
kinetic law: MODEL1310110019#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0d85e9e7_24ba_440d_8463_c7335647bc26
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1384
name: CRAT
initial concentration: NaN

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
type: Species
is: CHEBI:28095
boundary condition: false
is: SBO:0000247
name: 2-Amino-3-oxoadipate
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_2ad72b1c_9837_465d_aa1d_167ad8f67d29
is: P43007
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6509
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: SLC1A4

metaR r1566
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM dopa e
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:59905
is: SBO:0000247
type: Species
is: HMDB00073
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
name: dopaminium(1+)

http://identifiers.org/biomodels.db/MODEL1310110019#_d86857d9_67bb_43ba_88a4_ab0d686637f5
is: SBO:0000252
name: UCK2
type: Species
constant: false
boundary condition: true
is encoded by: hsa:7371
has only substance units: false
is: Q9BZX2
initial amount: NaN
initial concentration: NaN

metaR r1671
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaM ppbng c
is: SBO:0000247
is: CHEBI:58126
is: C00931
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial amount: NaN
is: HMDB00245
boundary condition: false
name: Porphobilinogen

metaR TRDR
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
is: SBO:0000176

metaM CE2424 m
is: SBO:0000247
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
initial concentration: 1.0
constant: false
is: CHEBI:28387

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58332
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_09db1bb6_30f0_48ae_b236_4f7fa244b3b3
name: CYBRD1
initial amount: NaN
type: Species
is: SBO:0000252
is: B4DWD7
constant: false
is encoded by: hsa:79901
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_efeaa0b2_8182_468c_b398_d3cb91ee5722
is encoded by: hsa:1375
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: CPT1B
type: Species
initial concentration: NaN
is: E9PCP2

metaM o2s e
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
has only substance units: false
is: CHEBI:18421
is: HMDB02168
boundary condition: false
name: superoxide
type: Species

metaM dhdascb e
name: dehydroascorbide(1-)
initial concentration: 1.0
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
boundary condition: false
is: CHEBI:58070
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01264
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_252f848c_514b_4e9d_b25a_19d0626182d0
initial amount: NaN
is: P11908
name: PRPS2
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5634
boundary condition: true

metaM ump m
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: CHEBI:57865
boundary condition: false
is: HMDB00288
name: UMP(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_219ccfa4_d977_430d_9f75_f0326d7c676f
name: AK2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:204
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR r0425
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
name: EC:1.1.1.42
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
fast: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r1565
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1670
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
reversible: true

metaM thf m
is: HMDB01846
has only substance units: false
is: CHEBI:57453
is: C00101
initial amount: NaN
type: Species
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR LPCOXp
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000269
name: L-pipecolate oxidase, peroxisomal
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.5.3.1

http://identifiers.org/biomodels.db/MODEL1310110019#_6ee503a9_df7c_4f89_baa8_94407facb15a
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: _HG2846_HT2983_1_m
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_987970d7_96a8_49ba_b61e_b22d29f73fc5
is encoded by: hsa:2582
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q38G75
has only substance units: false
name: GALE

http://identifiers.org/biomodels.db/MODEL1310110019#_68ed2883_3c21_45eb_8504_12377c1efc8f
constant: false
type: Species
is encoded by: hsa:11343
is: B2ZGL7
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: MGLL
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_efd8d732_0663_4d4e_8bc3_debf04a201f4
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5313
type: Species
is: SBO:0000252
is: P30613
name: PKLR
initial concentration: NaN

metaM crn c
is: HMDB00062
initial amount: NaN
boundary condition: false
name: L-Carnitine
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00318
is: CHEBI:16347

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM ump n
initial amount: NaN
is: CHEBI:57865
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00288
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_19dd315b_3bbf_44b6_9cce_ce0eb0c1f9d2
type: Species
has only substance units: false
name: UGT1A8
is: Q5DSZ6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:54576

http://identifiers.org/biomodels.db/MODEL1310110019#_ac235da8_5470_4427_b372_08105402eec5
type: Species
is encoded by: hsa:BC005314
boundary condition: true
constant: false
is: SBO:0000252
name: _BC005314_1_x
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR LEUKTRD4t
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reversible: true
fast: false
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
name: leukotriene D4 transport

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_85c708d2_06b5_46de_b092_e61d20e965b0
has part: P23921
name: RRM1:RRM2
has part: P31350
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6241
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_d0d44304_0817_4e43_a5eb_36a5a5e531c0
is: C5HZ13
has only substance units: false
is encoded by: hsa:1178
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: CLC

http://identifiers.org/biomodels.db/MODEL1310110019#_5a596921_e3dd_43ce_8782_54a6eb3ef613
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFB10
is: A8K761
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4716
constant: false

metaR r1564
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28002
type: Species
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952
has only substance units: false

metaR PGMT
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
modifier: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
name: phosphoglucomutase

http://identifiers.org/biomodels.db/MODEL1310110019#_76604c22_256f_4eb3_b359_20fd1a4cfc25
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1384
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: CRAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7aa8a0b6_d36d_4b7f_85be_5376a3feba31
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI640625
initial amount: NaN
name: _AI640625_1_c
has only substance units: false
type: Species

metaM dhdascb c
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
type: Species
is: SBO:0000247
name: dehydroascorbide(1-)
is: HMDB01264
is: CHEBI:58070
initial amount: NaN
boundary condition: false
constant: false

metaM o2s c
name: superoxide
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB02168
type: Species
is: CHEBI:18421
constant: false
has only substance units: false

metaM imp c
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
type: Species
name: IMP
constant: false
initial amount: NaN
is: C00130
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
boundary condition: false

metaR LEUKTRE4t
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: leukotriene E4 transport

metaR P45027A16m
name: Cytochrome P450 27
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
reactant: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR r1800
reversible: false
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#

metaR r0423
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d8a76420_c353_457a_8a7c_2ed2d600772d
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: ALDOA
is encoded by: hsa:226

metaR ACt2m
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
name: acetate mitochondrial transport via proton symport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000

metaR r1563
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000

metaM dolp L c
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683

metaR RE2079R
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
fast: false
name: RE2079
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_7c552a41_322a_4f6d_bdcc_ddcc1e93c187
is encoded by: hsa:1719
has only substance units: false
initial amount: NaN
is: P00374
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: DHFR

metaR DNDPt38m
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110019#
name: dUTP transport via dUDP antiport
reversible: false
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3ed26243_039f_479e_9542_3ec38903be4d
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: B4DK61
name: ACOX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_302dd678_6812_4f94_a094_8f0167ddfd9f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6470
is: P34896
boundary condition: true
has only substance units: false
name: SHMT1
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_74fedd5a_a117_46cc_b2e5_06db8b25c9bd
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:765
is: Q5FC00
has only substance units: false
name: CA6
constant: false

metaR r0801
modifier: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110019#

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_6001830f_1406_46df_92e4_f5099a36ddb2
is: SBO:0000252
has only substance units: false
name: UCKL1
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q53HM1
is encoded by: hsa:54963
initial amount: NaN

metaR r1803
reactant: MODEL1310110019#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: false
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d2b0f89b_f72a_4953_896d_a814d3c19784
type: Species
initial concentration: NaN
is: SBO:0000252
name: _D29675_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:D29675
constant: false
initial amount: NaN

metaR RE1523M
name: RE1523
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110019#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_fbbebb3d_87b3_449f_bd00_dc245e6eb4c0
name: COX7A2
initial concentration: NaN
is: H0UI06
is encoded by: hsa:1347
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR FERO
reversible: false
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000176
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_2425c783_60b5_44e7_8e0b_bb0a0b51744a
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AF080579
name: _AF080579_1_c
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6258fa0c_98e9_4f93_a096_0506049007c0
is: SBO:0000252
initial concentration: NaN
is: P22413
type: Species
has only substance units: false
is encoded by: hsa:5167
boundary condition: true
name: ENPP1
constant: false
initial amount: NaN

metaR DMATTx
is described by: ECO:0000134
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
reversible: false
name: dimethylallyltranstransferase
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110019#

metaR NAHCO3 HCLt
kinetic law: MODEL1310110019#
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_6fbf8d57_021b_4ed5_bdfe_b91cbd862add
constant: false
is encoded by: hsa:5297
boundary condition: true
is: B4DYG5
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: PI4KA
initial concentration: NaN

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM peamn c
has only substance units: false
is: SBO:0000247
name: 2-phenylethanaminium
constant: false
is: HMDB12275
boundary condition: false
type: Species
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
is: CHEBI:225237
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_af3869ea_676a_46a5_b2ca_8094bd04036a
initial amount: NaN
name: LDHAL6A
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:160287
initial concentration: NaN
is: Q6ZMR3
type: Species

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_41a70455_14ac_49e4_abe3_73fb035f15e8
is: SBO:0000252
is: O95528
name: SLC2A10
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:81031
initial amount: NaN

metaR HSD3A2r
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110019#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000

metaM 4mzym int2 r
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
has only substance units: false
type: Species
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 2
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR r1569
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#

metaM met L e
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00696
boundary condition: false
initial concentration: 1.0
is: CHEBI:16643
constant: false

metaR r1805
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110019#
name: Y+LAT2 Utilized transport
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaM malthp e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
name: maltoheptaose
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: C01936
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_2ae02dba_f684_4fdb_8415_61519db00211
is: C9JT23
initial amount: NaN
is encoded by: hsa:126328
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFA11
type: Species
initial concentration: NaN

metaM nh4 e
is: HMDB00051
constant: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial amount: NaN
is: CHEBI:28938
type: Species
boundary condition: false
initial concentration: 1.0
name: ammonium

metaR ACt2r
fast: false
name: acetate reversible transport via proton symport
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD

metaR r0999
is: SBO:0000185
reactant: MODEL1310110019#
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6175c117_5211_4cd2_ac57_e65464e640a0
constant: false
type: Species
name: NDUFC2
initial concentration: NaN
is: Q549M5
initial amount: NaN
is encoded by: hsa:4718
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0651
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110019#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false

metaR r0426
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.34
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#

metaR r1568
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaR PHEACGLNt
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
name: PHEACGLN extracellular transport via diffusion
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reversible: true

metaM gly x
initial amount: NaN
is: HMDB00123
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: glycine
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_64155e3c_a885_45e2_bf96_633d49ff892d
has only substance units: false
is: Q8TCD5
initial concentration: NaN
name: NT5C
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:30833
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_d55004f7_6ecb_40d3_87c4_38cbc0ef18ee
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:80308
initial amount: NaN
has only substance units: false
name: FLAD1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_4c09cf01_1b4b_4a38_9440_ecbd14d18684
boundary condition: true
has only substance units: false
is: P07451
is encoded by: hsa:761
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: CA3

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR PROt4 2 r
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000006
type: Reaction
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR r1318
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
name: Transport reaction
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_59d3347b_b296_41ec_afab_eeddc2f67006
is encoded by: hsa:79717
is: Q9HAB8
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PPCS
constant: false

metaM pmtcrn x
type: Species
is: HMDB00222
initial amount: NaN
is: CHEBI:17490
name: L-palmitoylcarnitine
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

metaR RE1845C
name: RE1845
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110019#
is: SBO:0000176

metaR r1567
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0650
reactant: MODEL1310110019#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1a7685d8_b66a_4713_8405_9adf4ae7dd4b
is: Q9NPB1
initial concentration: NaN
is encoded by: hsa:56953
constant: false
is: SBO:0000252
name: NT5M
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_eb5a746e_1d94_4dc5_87f8_5e99db6dff9e
is encoded by: hsa:51292
type: Species
has only substance units: false
boundary condition: true
is: Q9P2T1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: GMPR2

http://identifiers.org/biomodels.db/MODEL1310110019#_7560493c_76a2_4428_a78d_7c1bb74260e7
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9NY65
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: EHHADH
is encoded by: hsa:1962

metaR GLNyLATthc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_beccaea9_3865_4a6b_9408_9082ea145c26
constant: false
is: SBO:0000297
is encoded by: hsa:5160
type: Species
has part: P08559
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DLAT:DLD:PDHA1:PDHB:PDHX
boundary condition: true

metaR r0652
fast: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
type: Reaction
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
product: MODEL1310110019#

metaM q10h2 m
name: Ubiquinol-10
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
is: SBO:0000247
boundary condition: false
constant: false

metaM nac c
initial amount: NaN
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false
is: C00253
is: CHEBI:0
constant: false
is: HMDB01488
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Nicotinate
boundary condition: false

metaM pmtcrn r
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17490
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
is: HMDB00222
boundary condition: false

metaM o2s m
constant: false
boundary condition: false
is: CHEBI:18421
has only substance units: false
is: HMDB02168
is: C00704
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

http://identifiers.org/biomodels.db/MODEL1310110019#_00c6db07_bb86_4f2d_8ed0_360c01cbbdf2
type: Species
boundary condition: true
is encoded by: hsa:NM 001929
is: SBO:0000252
has only substance units: false
name: _NM_001929_1_c
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ff2a2fde_2e55_42a7_8c48_8e952cbca58e
constant: false
type: Species
is: SBO:0000252
name: SLC16A3
is encoded by: hsa:9123
initial amount: NaN
initial concentration: NaN
is: O15427
boundary condition: true
has only substance units: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM clpn hs c
type: Species
is: HMDB00156
has only substance units: false
notes: FORMULA: CHARGE: 0
name: clpn_hs[c]
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:15589
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_5f6d6632_2832_4887_a2a8_00ee02b894e5
is encoded by: hsa:9194
name: SLC16A7
is: Q8NEM3
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_6c9891e2_21df_4de5_929c_48345224a382
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: MTMR2
has only substance units: false
boundary condition: true
is encoded by: hsa:8898
type: Species
is: A6NN98

http://identifiers.org/biomodels.db/MODEL1310110019#_61b61149_89a3_4398_ac0a_8d43719ac6a5
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: P48651
boundary condition: true
name: PTDSS1
is encoded by: hsa:9791
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_578d1ac6_8e50_4847_bfc4_7fd939143e7a
is: P07205
constant: false
has only substance units: false
name: PGK2
is encoded by: hsa:5232
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_a3ed7392_d78d_4692_8282_097ebc3a2fd7
is: SBO:0000252
constant: false
is: Q9ULD0
type: Species
initial concentration: NaN
is encoded by: hsa:55753
has only substance units: false
name: OGDHL
boundary condition: true
initial amount: NaN

metaR r0653
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110019#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaM 3hbcoa m
is: CHEBI:57316
is: HMDB01166
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
constant: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false

metaM 2mop c
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 2-methyl-3-oxopropanoate
initial amount: NaN
is: CHEBI:57700
type: Species
has only substance units: false
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false

metaM 4ppan c
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: D-4'-Phosphopantothenate
is: HMDB01016
type: Species
is: C03492
initial amount: NaN
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492

metaR SERCYSNaEx
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)

http://identifiers.org/biomodels.db/MODEL1310110019#_b11cbcb2_f5ef_40c6_b381_86827dbf2d88
boundary condition: true
initial amount: NaN
is encoded by: hsa:8875
constant: false
initial concentration: NaN
has part: O95497
is encoded by: hsa:55350
has only substance units: false
name: VNN3:VNN2:VNN1
type: Species
has part: A8K7W0
is: SBO:0000297
is encoded by: hsa:8876

http://identifiers.org/biomodels.db/MODEL1310110019#_ef028ecc_24da_4584_9672_7a6d5813dd79
has only substance units: false
constant: false
name: _AV717590_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:AV717590
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM tsul e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16094
constant: false
boundary condition: false
is: HMDB00257
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
has only substance units: false
type: Species

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
fast: false
reversible: true
product: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110019#
name: RE0958

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: false
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
is described by: ECO:0000000
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1

http://identifiers.org/biomodels.db/MODEL1310110019#_c75086fa_c30a_4a0e_873d_1563b3a7ca5f
type: Species
name: SGMS1
boundary condition: true
is: D3DWC4
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:259230

metaM bhb e
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:10983
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
constant: false
name: (R)-3-hydroxybutyrate

metaR TDCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is: SBO:0000185
name: bile acid intracellular transport
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b5ffeda7_ce98_47cd_9068_433e08e89e1e
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10201
constant: false
name: NME6
is: O75414
has only substance units: false
type: Species

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
type: Species
name: betaine aldehyde
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01252
initial amount: NaN
is: CHEBI:15710
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_9ff259ed_a62d_4bfc_995c_f5d69649bed8
is encoded by: hsa:374291
type: Species
is: O75251
name: NDUFS7
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR VALTAm
type: Reaction
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: valine transaminase, mitochondiral
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_d580f80f_7046_4164_a341_e1523e203dfb
is: SBO:0000252
initial amount: NaN
name: SLC6A10P
is encoded by: hsa:386757
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM pep c
is: HMDB00263
is: C00074
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
name: Phosphoenolpyruvate
type: Species
is: SBO:0000247
is: CHEBI:18021
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_add5bd74_1e2f_41a8_88b8_04170f05e023
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8399
name: PLA2G10
has only substance units: false
boundary condition: true
type: Species
is: O15496
initial concentration: NaN

metaR RE3627M
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110019#
is described by: ECO:0000000
name: RE3627
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
reactant: MODEL1310110019#

metaR RDH2a
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (9-cis,NADPH)
is described by: ECO:0000269
product: MODEL1310110019#
is: SBO:0000176
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_43548c82_88a1_4078_b8f5_b0ef540caf6d
initial amount: NaN
type: Species
constant: false
is: P35754
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2745
boundary condition: true
name: GLRX
is: SBO:0000252

metaR IZPN
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
reversible: false
is: SBO:0000176
fast: false
name: Imidazolonepropionase
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000

metaR THYOXt
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
name: T4 transport via bicarbonate countertransport

http://identifiers.org/biomodels.db/MODEL1310110019#_1af6f332_30bf_4262_a6f0_0ba40c50ae75
boundary condition: true
is: Q02218
is encoded by: hsa:4967
name: OGDH
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR r0655
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10

http://identifiers.org/biomodels.db/MODEL1310110019#_bed57296_9a91_4e52_8340_b3a2b4aaa968
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:54995
is: Q9NWU1
initial amount: NaN
boundary condition: true
has only substance units: false
name: OXSM

metaM 3mob c
type: Species
constant: false
is: SBO:0000247
is: HMDB00019
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false
initial amount: NaN
has only substance units: false
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851

metaR TALA
type: Reaction
kinetic law: MODEL1310110019#
name: transaldolase
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.2.1.2
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_08724ca9_5be5_4959_86ec_834a1d8bff1c
constant: false
initial amount: NaN
boundary condition: true
name: MTHFD2L
type: Species
is: Q9H903
has only substance units: false
is: SBO:0000252
is encoded by: hsa:441024
initial concentration: NaN

metaR r0193
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reversible: true
fast: false
type: Reaction
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176

metaR LYSOXp
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reversible: false
name: L-lysine oxidase, peroxisomal
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is: SBO:0000176
type: Reaction
fast: false

metaM HC00695 m
is: CHEBI:17432
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: S-Succinyldihydrolipoamide
is: SBO:0000247

metaR CHOLtu
name: Choline uniport
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_225ad03b_4e1e_42aa_83d3_462561517554
initial amount: NaN
is: SBO:0000252
name: COX8A
boundary condition: true
constant: false
type: Species
is: Q53XN1
is encoded by: hsa:1351
initial concentration: NaN
has only substance units: false

metaR GTHRDtr
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
product: MODEL1310110019#
type: Reaction
reversible: true
name: glutathione transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_a8c55833_c0f6_4f02_8fea_6363fba7669d
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PTDSS2
type: Species
is encoded by: hsa:81490
initial concentration: NaN
is: Q9BVG9
constant: false

metaR r0196
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37

metaM hmgcoa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
type: Species
constant: false
is: HMDB01375
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA

metaR r0656
product: MODEL1310110019#
reactant: MODEL1310110019#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_62414b36_c2e8_466e_a4d3_b6935958f6cf
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P23786
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252
constant: false
type: Species
name: CPT2

http://identifiers.org/biomodels.db/MODEL1310110019#_1e02e1d4_52f7_4f43_bc19_7af0981443db
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:56606
type: Species
name: SLC2A9

metaR ARGtiDF
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000269
name: L-arginine transport via diffusion (extracellular to cytosol)
reversible: false
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaM HC02175 e
is: CHEBI:27689
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
boundary condition: false
name: caprate
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_4c5112d7_e795_4272_96ff_8962612b9499
initial amount: NaN
boundary condition: true
type: Species
name: GGT5
constant: false
is: SBO:0000252
is encoded by: hsa:2687
is: P36269
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_7d8a28c7_3558_470e_81c3_726069ac8ece
constant: false
is encoded by: hsa:22978
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P49902
initial amount: NaN
boundary condition: true
name: NT5C2

metaM akg e
initial amount: NaN
name: 2-oxoglutarate(2-)
is: CHEBI:16810
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00208
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e8549175_e0db_41c5_90fe_cf9da3c651bb
is encoded by: hsa:25902
constant: false
type: Species
is: SBO:0000252
is: B2RD24
boundary condition: true
initial concentration: NaN
name: MTHFD1L
initial amount: NaN
has only substance units: false

metaR HYXNt
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Hypoxanthine transport
type: Reaction
product: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269

metaM fe2 m
boundary condition: false
name: Fe2+
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: C00023
type: Species
is: SBO:0000247
is: HMDB00692

http://identifiers.org/biomodels.db/MODEL1310110019#_b2072cab_7887_49a5_bd9d_28f1c72ded4e
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NM 013421
type: Species
constant: false
name: _NM_013421_1_e
initial amount: NaN
boundary condition: true

metaM 4izp c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01014
is: CHEBI:57255
type: Species
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
name: 4-Imidazolone-5-propanoate
is: SBO:0000247
constant: false
has only substance units: false

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR RE3000M
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3000
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#

metaM sucsal m
is: HMDB01259
name: Succinic semialdehyde
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57706
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232

metaM 5aop m
is: C00430
has only substance units: false
constant: false
is: HMDB01149
is: CHEBI:17549
boundary condition: false
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247

metaR RE0944E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
name: RE0944
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_26d0b4ca_5309_4346_8c66_9e4e92b7563c
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: A1L4Q0
initial amount: NaN
name: DGKE
constant: false
type: Species
is encoded by: hsa:8526

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM pmtcrn m
is: CHEBI:17490
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-palmitoylcarnitine
is: HMDB00222
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN

metaR r1464
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport

metaR DGSNt
is: SBO:0000185
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoyguanosine transport via diffusion
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_1df64cf5_3065_47e7_848a_d3bb7c2a4eea
constant: false
is encoded by: hsa:4718
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: NDUFC2
is: SBO:0000252
has only substance units: false
is: Q549M5

metaR DTTPtn
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: dTTP diffusion in nucleus

metaM g3pc c
is: HMDB00086
has only substance units: false
boundary condition: false
name: sn-Glycero-3-phosphocholine
is: CHEBI:16870
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaR FUMtm
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110019#
fast: false
name: fumarate transport, mitochondrial
reversible: true
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
is: SBO:0000185

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_9d0fe960_92ae_41b3_abea_7c95440e879b
boundary condition: true
name: _AI222095_1_m
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI222095
initial amount: NaN

metaR SUCCt2m
kinetic law: MODEL1310110019#
is: SBO:0000185
name: succinate transport, mitochondrial
reversible: true
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110019#_50ce3b9d_2a9d_443c_b40b_07fc80a199f4
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: AK3
is: E7ET30
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:50808

metaR DTMPK
is version of: http://identifiers.org/ec-code/2.7.4.9
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: dTMP kinase
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_91592b54_c9f9_4944_8774_c93d98a7961a
type: Species
name: ENTPD1
is: Q86VV3
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:953
constant: false

metaM HC02175 c
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
boundary condition: false
name: caprate
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_17611380_3e1b_40da_8eb0_a5b7d56cf934
constant: false
initial concentration: NaN
name: PKM2
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252

metaR RE0452M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reversible: true
fast: false
name: RE0452
is: SBO:0000176
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_6c0fa2ea_e2f6_4947_9b1b_8c37cae08445
is: F5H066
boundary condition: true
is encoded by: hsa:6560
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: SLC12A4
initial concentration: NaN

metaM akg c
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 2-Oxoglutarate
constant: false
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: CHEBI:16810
is: HMDB00208
is: C00026
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_d033370a_e6f5_4002_a5e5_5b3426f5b210
initial concentration: NaN
constant: false
is: Q96CD2
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:60490
name: PPCDC

metaM acrn c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
is: CHEBI:57589
is: HMDB00201
has only substance units: false
name: O-acetylcarnitine
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e0fe5880_d3e8_49b9_a731_46ed411bcb70
has only substance units: false
type: Species
is encoded by: hsa:5471
boundary condition: true
name: PPAT
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: Q06203

http://identifiers.org/biomodels.db/MODEL1310110019#_f208dfaf_c31b_446e_adb4_a642259e7505
initial concentration: NaN
boundary condition: true
constant: false
is: P14618
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5315
name: PKM2
has only substance units: false

metaR URCN
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: URCN
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b579976b_eeaa_446a_a47a_ac10eac76188
boundary condition: true
is: P48764
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6550
has only substance units: false
is: SBO:0000252
name: SLC9A3

metaM hpyr c
is: CHEBI:17180
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
constant: false
is: HMDB01352
type: Species
name: 3-hydroxypyruvate
initial amount: NaN
boundary condition: false

metaM 5aizc c
is: CHEBI:58564
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
constant: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
boundary condition: false
is: C04751
initial concentration: 1.0
is: HMDB06273
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_8e84f74a_bdb5_4c2f_8602_eb90f92f46cf
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q7GXY9
is encoded by: hsa:4536
name: ND2
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_cbaacf30_394d_4d21_af56_6ebb58d74190
initial amount: NaN
has only substance units: false
is: O14556
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:26330
name: GAPDHS
boundary condition: true
is: SBO:0000252

metaR NDP8
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.9
type: Reaction
reversible: false
reactant: MODEL1310110019#
name: nucleoside-diphosphatase (dUDP)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_75d66a68_0c91_47fb_bbc8_6753e8d023e8
has only substance units: false
constant: false
name: AK2
is: SBO:0000252
is encoded by: hsa:204
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: P54819

metaM arachdcoa c
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57368
has only substance units: false

metaR CYTK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110019#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110019#
name: cytidylate kinase (CMP,UTP),nuclear
type: Reaction

metaM xol7aone r
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01993
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899

http://identifiers.org/biomodels.db/MODEL1310110019#_8b5bf069_ec12_4d7c_a13b_362432c98309
is encoded by: hsa:5860
name: QDPR
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P09417
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR LEUKTRA4tr
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: leukotriene intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaM q10h2 e
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
type: Species
is: HMDB13111

http://identifiers.org/biomodels.db/MODEL1310110019#_35163206_bc1e_49ef_bfe7_1e3741014315
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64600
type: Species
is: Q9BZM2
constant: false
boundary condition: true
initial amount: NaN
name: PLA2G2F

metaR r1926
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2352
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110019#

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d638878c_8123_4c2b_8dd1_25aefa5fa7c1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: _AI222095_1_e
initial concentration: NaN
is encoded by: hsa:AI222095

http://identifiers.org/biomodels.db/MODEL1310110019#_c3ff05bd_88d0_42f0_ae4b_9ae6ba24299b
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4700
name: NDUFA6
initial concentration: NaN
is: P56556

metaR CLOXAtex2
is described by: ECO:0000304
is: SBO:0000185
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
product: MODEL1310110019#
name: chloride transport via oxalate countertransport (2:1)
reactant: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#

metaR DHAAt1r
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110019#
name: dehydroascorbate transport (uniport)
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR PPPG9tm
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: protoporphyrinogen IX mitochondrial transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM leugly c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Leucylglycine
notes: FORMULA: C8H16N2O3 CHARGE: 0
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
boundary condition: false

metaR CYSSERNaEx
reactant: MODEL1310110019#
type: Reaction
fast: false
is described by: ECO:0000269
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_8cefa754_e56a_47b2_b74d_4463eade536f
is: SBO:0000252
name: PANK4
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55229
initial amount: NaN
is: Q9NVE7
type: Species

metaR 34DHOXPEGOX
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
modifier: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
is: SBO:0000176

metaM man1p c
constant: false
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:35374
initial concentration: 1.0
is: HMDB06330
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_04124e33_16d3_42c1_908d_2f5bedb62285
has only substance units: false
constant: false
boundary condition: true
name: FOLR1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2348
initial concentration: NaN

metaR PNTK
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
name: pantothenate kinase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false

metaR r1925
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3d17a625_2dcc_43e6_ae69_8b3376738d29
is: Q9Y5P6
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:29925
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: GMPPB

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR CHATn
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
type: Reaction
fast: false
reversible: true
name: Choline O-acetyltransferase
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_3e9ade31_6325_4ad3_8a09_4144860c3074
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:211
boundary condition: true
name: ALAS1
is: P13196
has only substance units: false
type: Species

metaM pser L c
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: O-Phospho-L-serine
initial concentration: 1.0
is: HMDB01721
is: CHEBI:15811
type: Species
constant: false

metaM acrn m
initial concentration: 1.0
boundary condition: false
type: Species
name: O-acetylcarnitine
is: HMDB00201
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
constant: false
is: CHEBI:57589

metaR BILIRUBt2
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110019#
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_b8f90d94_397f_4c84_b250_b35d5cd23b5b
has only substance units: false
name: SCP2
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6342
initial concentration: NaN
is: C9JC79

metaR r0311
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_fbee6700_e50e_4da7_afee_8a3e63385678
is encoded by: hsa:125206
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: SLC5A10
initial concentration: NaN
type: Species
initial amount: NaN
is: A0PJK1

http://identifiers.org/biomodels.db/MODEL1310110019#_c92c3835_8d22_4148_968d_fa64cbba1d1b
is: SBO:0000297
has part: P00709
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2683
boundary condition: true
has part: P15291
is encoded by: hsa:3906
name: B4GALT1:LALBA
initial amount: NaN

metaM leuktrC4 r
is: HMDB01198
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57973
name: leukotriene C4(2-)
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_0aac9f39_a7d5_4672_8e91_624d64439ee4
initial concentration: NaN
is: P41222
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5730
type: Species
constant: false
name: PTGDS
initial amount: NaN

metaM q10h2 c
is: HMDB13111
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
name: Ubiquinol-10
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaR RE2998M
fast: false
kinetic law: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
name: RE2998

metaM tsul m
is: SBO:0000247
boundary condition: false
name: thiosulfate(2-)
has only substance units: false
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
initial amount: NaN
constant: false
is: HMDB00257
initial concentration: 1.0

metaM 3mgcoa m
boundary condition: false
initial concentration: 1.0
is: HMDB01057
initial amount: NaN
name: trans-3-methylglutaconyl-CoA(5-)
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: SBO:0000247
is: CHEBI:57346
type: Species
has only substance units: false
constant: false

metaR O2t
is: SBO:0000185
reactant: MODEL1310110019#
name: o2 transport (diffusion)
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_5690ab39_5330_4df0_b094_0cfe86dbb238
is: SBO:0000252
initial amount: NaN
name: ABCD1
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:215
is: P33897
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b216d571_ca82_4bc7_85af_fa967093c112
constant: false
boundary condition: true
is: SBO:0000252
name: FTCD
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10841

metaM leugly e
initial amount: NaN
initial concentration: 1.0
name: Leucylglycine
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/97364
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM bhb m
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00011
constant: false
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_62c45f42_28ba_4006_adf0_43ae7a81c8ac
constant: false
name: IDH1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3417
type: Species
boundary condition: true
initial amount: NaN
is: O75874
is: SBO:0000252

metaM HC00361 c
initial concentration: 1.0
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
is: CHEBI:58335
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c12c006f_651c_415b_8698_e429189c956d
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI972237
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI972237_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_60c03247_7732_42eb_bad7_060ab8287b16
is encoded by: hsa:80025
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q6P1K9
has only substance units: false
type: Species
initial concentration: NaN
name: PANK2

metaR r0310
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: false
reactant: MODEL1310110019#

metaR URIt5le
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
name: uridine transport in via sodium symport (1:2)

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110019#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.1.1.17

metaR LEUt5m
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: leucine mitochondrial transport
type: Reaction
is: SBO:0000185

metaM pan4p c
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: C01134
type: Species
is: HMDB01416
initial concentration: 1.0
is: CHEBI:47942

metaR ADNt4
name: adenosine transport (Na/Adn cotransport)
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
reversible: false
fast: false

metaR FTCD
type: Reaction
name: formimidoyltransferase cyclodeaminase
is described by: ECO:0000134
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_60284868_2545_45b9_9c8a_1f6666ac8d1b
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: DGUOK
boundary condition: true
is encoded by: hsa:1716
has only substance units: false

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/2.7.7.72
fast: false
reactant: MODEL1310110019#

metaM L2aadp6sa c
initial amount: NaN
is: SBO:0000247
is: CHEBI:17917
type: Species
has only substance units: false
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
boundary condition: false
is: HMDB01263
initial concentration: 1.0

metaR AIRCr
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110019#
is: SBO:0000176
fast: false
modifier: MODEL1310110019#
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.2.6
kinetic law: MODEL1310110019#
is described by: ECO:0000269

metaM dolp L r
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
has only substance units: false
name: dolichyl phosphate(2-)
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57683
initial amount: NaN

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_39547a34_0056_41b8_b270_f22ea1757148
has only substance units: false
constant: false
is: SBO:0000252
name: _D87002_1_m
is encoded by: hsa:D87002
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR SERTHRNaEx
product: MODEL1310110019#
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_50a4e607_a3b2_4e10_8d5a_a882a608f9a9
type: Species
initial amount: NaN
name: HSD17B10
is encoded by: hsa:3028
boundary condition: true
initial concentration: NaN
is: Q99714
has only substance units: false
constant: false
is: SBO:0000252

metaM fe2 e
constant: false
is: HMDB00692
is: C00023
type: Species
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Fe2+

metaR MI14PP
modifier: MODEL1310110019#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.57
name: inositol-1,4-bisphosphate 1-phosphatase
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_ea818784_52f2_4343_8be6_89e571177b99
initial amount: NaN
constant: false
is: P13686
is encoded by: hsa:54
type: Species
name: ACP5
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR LTD4DP
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM lpam m
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17460
is: HMDB00962
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
name: lipoamide
type: Species

metaR DMNONCOACRNCPT1
fast: false
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
name: DMNONCOACRNCPT1
type: Reaction
is described by: ECO:0000000

metaM dutp m
is: CHEBI:17625
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01191
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
boundary condition: false
name: dUTP

metaR r2141
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110019#_d4de9f39_07f7_453d_bf18_2123cdab432d
is encoded by: hsa:51102
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: MECR
constant: false
is: Q9BV79
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_66ffe2e5_3bd6_4a0e_8199_9441725c0db4
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3550
name: IK
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q13123

metaR THFtm
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110019#_99287d8f_99a5_462e_aad1_e42ba6b3b700
constant: false
is encoded by: hsa:5287
has only substance units: false
boundary condition: true
is: O00750
is: SBO:0000252
name: PIK3C2B
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f9f7a5fd_72ed_44ec_b09c_8196d0502416
type: Species
initial concentration: NaN
is encoded by: hsa:84105
name: PCBD2
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9H0N5
has only substance units: false

metaM HC02202 c
boundary condition: false
constant: false
is: CHEBI:57398
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM HC02216 e
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
name: prostaglandin-f2beta
is: CHEBI:28922
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_df887148_791e_46c1_875f_7aea80023617
has only substance units: false
name: NME1:NME2
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4830
constant: false
type: Species
boundary condition: true

metaR C3STDH1Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0c6ff1b4_f1e8_427a_bd84_2c34e74826e7
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: NDUFS5
is encoded by: hsa:4725
constant: false
is: Q6IBA0
is: SBO:0000252
type: Species

metaM dutp n
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17625
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
initial amount: NaN
name: dUTP
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_955d7d73_4fcc_4573_9fbb_8c7d7e192384
constant: false
type: Species
name: PDHA2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P29803
is encoded by: hsa:5161
initial concentration: NaN
has only substance units: false

metaM but e
initial concentration: 1.0
name: butyrate
boundary condition: false
is: SBO:0000247
is: HMDB00039
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:17968
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaR r2142
modifier: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_71603a04_c939_4701_a02d_b1a4df404606
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:51
initial amount: NaN
initial concentration: NaN
name: ACOX1
is: B4DK61

metaM pan4p e
is: C01134
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: SBO:0000247
is: HMDB01416
type: Species
is: CHEBI:47942
boundary condition: false

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR r1921
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e90beff6_37ef_4b0b_92fc_6c7bded147ad
initial amount: NaN
boundary condition: true
constant: false
name: SLC2A14
initial concentration: NaN
is encoded by: hsa:144195
type: Species
is: SBO:0000252
has only substance units: false
is: Q8TDB8

http://identifiers.org/biomodels.db/MODEL1310110019#_c61a77d3_145c_43b4_841f_c7eae8854854
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4522
name: MTHFD1
is: P11586
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_4a95e42a_c142_4dcc_9369_1aec9d34f3f4
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4199
is: P48163
has only substance units: false
name: ME1

metaR ALOX52
fast: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
product: MODEL1310110019#
name: Arachidonate 5-lipoxygenase
is described by: ECO:0000269
modifier: MODEL1310110019#
reversible: false

metaR GAPD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
modifier: MODEL1310110019#
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
type: Reaction

metaM hmgcoa c
name: Hydroxymethylglutaryl-CoA
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
is: HMDB01375
type: Species
boundary condition: false
constant: false

metaR THRPHELAT2tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM fe2 c
constant: false
is: C00023
type: Species
is: HMDB00692
has only substance units: false
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Fe2+
initial amount: NaN

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM HC02202 e
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r0545
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
modifier: MODEL1310110019#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39

http://identifiers.org/biomodels.db/MODEL1310110019#_0b33d87d_4b7b_4170_967f_23d8c198389e
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:BE966236
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _BE966236_1_m

http://identifiers.org/biomodels.db/MODEL1310110019#_6d3409a2_40da_4eb9_94cb_1e9a4df8ea42
is: Q96P26
constant: false
initial amount: NaN
has only substance units: false
name: NT5C1B
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:93034
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_33182b5e_99bb_4b9e_b5fa_44729d566bd6
has only substance units: false
is encoded by: hsa:6392
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SDHD
type: Species
boundary condition: true
is: O14521

metaR GLYBt4 2 r
product: MODEL1310110019#
is described by: ECO:0000269
name: Betaine transport (sodium symport) (2:1)
type: Reaction
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1ab873d6_3190_4f31_b8dc_7721217f3f29
name: NDUFS5
has only substance units: false
is encoded by: hsa:4725
is: SBO:0000252
is: Q6IBA0
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM HC02216 c
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false
is: SBO:0000247
is: CHEBI:28922
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_3acd1b09_b89a_426e_9046_a28cf9d91cf8
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ENPP1
is encoded by: hsa:5167
is: SBO:0000252
boundary condition: true
is: P22413
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_a7de05f8_f815_4979_bc75_99c89b0dd749
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1375
initial amount: NaN
is: SBO:0000252
name: CPT1B
boundary condition: true
is: Q92523

metaR AACOAT
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Acetoacetyl-CoA:acetate CoA-transferase
is: SBO:0000176
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD

metaM but c
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
name: butyrate
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_1d8d6ffd_1ada_4ee3_87d2_90a95e894b58
boundary condition: true
constant: false
name: CPT1A
initial concentration: NaN
type: Species
initial amount: NaN
is: Q8WZ48
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1374

metaR DCMPDA
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110019#
name: dCMP deaminase
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.12
modifier: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a2a2fce4_9c45_4438_a41c_80a23422770b
initial concentration: NaN
initial amount: NaN
type: Species
name: _BE042354_1_m
boundary condition: true
is encoded by: hsa:BE042354
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_26825c66_95b0_40be_adf3_7e2c0dda1b5a
boundary condition: true
name: MCCC1:MCCC2
has part: Q96RQ3
has part: Q9HCC0
type: Species
is encoded by: hsa:64087
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:56922

metaR r2140
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110019#
reversible: true
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM crn x
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
type: Species
name: L-Carnitine
boundary condition: false
initial amount: NaN
constant: false
is: C00318
is: HMDB00062
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_271735ab_53b5_4026_83a9_fba301ad8195
type: Species
is: Q96C36
initial amount: NaN
boundary condition: true
name: PYCR2
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29920

metaM 5aop c
is: C00430
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
has only substance units: false
name: 5-Amino-4-oxopentanoate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17549

metaR r1579
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110019#

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM oxa c
is: HMDB02329
name: oxalate(2-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
is: CHEBI:30623
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_e4ffc873_1283_4891_a421_40dcabd7292a
is encoded by: hsa:2030
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC29A1
is: Q99808
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_5c6b2e35_db56_4d1d_852b_8c65227ac4ca
name: SLC3A2
initial concentration: NaN
is: P08195
is encoded by: hsa:6520
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM fol c
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: Folate
is: HMDB00121
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_df2a7fb8_20ba_4594_b31e_2553de13017e
initial amount: NaN
is encoded by: hsa:64781
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: CERK
type: Species

metaM dttp e
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:37568
initial amount: NaN
is: HMDB01342
name: dTTP(4-)
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: Mesaconyl-CoA
initial concentration: 1.0
is: C06028
is: SBO:0000247
has only substance units: false
is: CHEBI:27969

metaM ser D c
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB03406

metaR r0629
reactant: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
reversible: true
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.6.1.22
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction

metaR RE2269E
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110019#
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.4.21.39
modifier: MODEL1310110019#

metaR DNDPt22m
is described by: ECO:0000269
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110019#
reversible: false
type: Reaction
name: dTDP transport via dUDP antiport
kinetic law: MODEL1310110019#

metaM trdrd c
initial amount: NaN
constant: false
has only substance units: false
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15967
type: Species
name: Reduced thioredoxin

metaR r2314
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaM 13 cis retn r
is: HMDB06219
is: D00348
is: SBO:0000247
name: 13-cis-retinoate
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414

http://identifiers.org/biomodels.db/MODEL1310110019#_74271323_7ede_495d_b20c_e944d81b822a
initial concentration: NaN
name: PRPS1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5631
constant: false
boundary condition: true
has only substance units: false
is: P60891

W3 CDTF: Fri Aug 31 06:19:07 BST 2012

metaR FBA2
is described by: ECO:0000304
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
type: Reaction

metaM bilglcur e
type: Species
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
is: SBO:0000247
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_800e6790_8a6c_47f9_9880_d9d6cf83519e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: INPP4A
type: Species
is encoded by: hsa:3631
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_295c5c11_7d4f_408f_a3b0_d28325ea0a68
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4830
type: Species
name: NME1
has only substance units: false
is: SBO:0000252
is: P15531
boundary condition: true

metaR GLYCLTDy
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.79
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
name: Glycolate dehydrogenase (NADP)
type: Reaction
is described by: ECO:0000269

metaR r2313
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110019#

metaM ac c
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00042
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
initial amount: NaN
type: Species
initial concentration: 1.0

metaM pa hs c
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
is: CHEBI:57739
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: phosphatidate(2-)

http://identifiers.org/biomodels.db/MODEL1310110019#_6835a13f_649f_4028_8625_361335b388cc
initial amount: NaN
type: Species
is: P49914
initial concentration: NaN
name: MTHFS
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:10588

metaM glutcoa m
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN
is: CHEBI:57378
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB01339
boundary condition: false
name: glutaryl-CoA(5-)

metaM oxa e
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:30623
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329

metaM o2 m
initial concentration: 1.0
is: C00007
is: HMDB01377
name: O2
is: SBO:0000247
is: CHEBI:15379
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
constant: false

metaR r0480
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_6050a8f7_3dc2_4384_8543_86e27c70f831
has only substance units: false
name: VNN3:VNN2:VNN1
boundary condition: true
is encoded by: hsa:55350
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR NTD6
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
reversible: false

metaM dtmp e
initial amount: NaN
has only substance units: false
is: CHEBI:26999
name: dTMP(2-)
is: HMDB01227
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_3ded4f0b_6676_47b3_ae41_0432b87b3fbd
is encoded by: hsa:11254
has only substance units: false
constant: false
name: SLC6A14
type: Species
boundary condition: true
is: Q9UN76
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_08964152_afea_4dd5_b41b_d92b8b1cde06
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9377
type: Species
is: SBO:0000252
name: COX5A
is: P20674
constant: false

metaM citr L e
initial concentration: 1.0
name: citr_L[e]
initial amount: NaN
boundary condition: false
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00904

metaM 5dpmev c
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
type: Species
constant: false
is: HMDB01090
initial concentration: 1.0
name: (R)-5-Diphosphomevalonate
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
product: MODEL1310110019#

metaR METtec
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
fast: false
name: L-methionine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0e048133_5b8b_4f1f_b043_34b4157ef234
initial concentration: NaN
has only substance units: false
is encoded by: hsa:374291
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: O75251
name: NDUFS7
constant: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM prostgd2 c
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: prostaglandin D2(1-)
type: Species
is: HMDB01403
has only substance units: false
is: CHEBI:57406
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaM pppg9 m
is: CHEBI:57307
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: Protoporphyrinogen IX
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
is: C01079
is: HMDB01097
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c9a995c6_5cb7_45db_9255_98a7f3d403a9
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: SLC38A4
initial concentration: NaN
is: Q969I6
type: Species
is: SBO:0000252
is encoded by: hsa:55089

metaR GLNS
name: glutamine synthetase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110019#
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.15
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e3b787ae_22d8_404a_b2d6_2dfa4827b69d
is encoded by: hsa:AI620219
type: Species
name: _AI620219_1_e
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_89940822_3a70_4b81_9a2e_eebade2ef29f
is: P49247
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:22934
type: Species
initial concentration: NaN
name: RPIA

metaM glyald c
boundary condition: false
name: D-Glyceraldehyde
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
type: Species
has only substance units: false
is: C00577
is: SBO:0000247
is: CHEBI:17378
initial concentration: 1.0
initial amount: NaN

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR r2420
product: MODEL1310110019#
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110019#

metaR C4STMO1r
reversible: false
type: Reaction
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110019#
is described by: ECO:0000000
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ

metaR HMBS
reversible: false
type: Reaction
name: hydroxymethylbilane synthase
is version of: http://identifiers.org/ec-code/2.5.1.61
kinetic law: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
is described by: ECO:0000254
fast: false

metaR r2315
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_aa94e407_37da_427c_b635_13936e27b07f
type: Species
has only substance units: false
is: Q53H96
is encoded by: hsa:65263
name: PYCRL
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_8eb3001e_ec02_48c7_a593_5576f70aabfa
name: ETNK2
is encoded by: hsa:55224
constant: false
type: Species
is: Q9NVF9
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM dadp c
name: dADP
is: HMDB01508
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
is: CHEBI:57667
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00206

metaM ac e
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: CHEBI:30089
initial amount: NaN
constant: false
is: SBO:0000247
name: acetate
has only substance units: false
type: Species
boundary condition: false
is: HMDB00042

http://identifiers.org/biomodels.db/MODEL1310110019#_f78a1886_8ac3_4d98_9110_4bf8ce16ba46
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AA278423
name: _AA278423_1_c
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR r1575
reactant: MODEL1310110019#
reversible: true
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PROD2
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000254
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
name: Proline dehydrogenase
fast: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
reversible: false

metaM acetone c
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: acetone
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01659
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaR CYSGLUexR
modifier: MODEL1310110019#
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110019#
type: Reaction
reversible: true
product: MODEL1310110019#
fast: false
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#

metaR RE1447N
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_790eeb58_cc0c_4802_92e2_7280414fa335
initial amount: NaN
constant: false
is: SBO:0000252
is: Q5VYT2
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFB6
type: Species
is encoded by: hsa:4712

metaR CERT2rt
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
fast: false
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#

metaR r1657
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_eab097b3_7eba_4c8f_b341_c462bbd654c3
is: SBO:0000252
name: GMPR2
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:51292
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_f7373f23_f43b_478a_b1d6_2b4b8fc0c0a9
constant: false
name: ALDH1B1
boundary condition: true
is: P30837
is encoded by: hsa:219
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r2318
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR DUMPtn
name: dUMP nuclear transport
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
reversible: true

metaR CHOLtn
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110019#
name: Choline transport, nuclear through pores

metaM 1pyr5c m
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: C03912
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
is: HMDB01301
has only substance units: false
is: CHEBI:15893

metaM citr L c
constant: false
boundary condition: false
is: HMDB00904
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
is: CHEBI:16349
name: L-citrulline
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r0839
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaM succ x
has only substance units: false
name: Succinate
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00254
is: C00042
initial concentration: 1.0
is: CHEBI:30031
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR RE3326M
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
reactant: MODEL1310110019#
fast: false
name: RE3326
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
is: CHEBI:15740
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: formate
constant: false
initial concentration: 1.0

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR r1576
is: SBO:0000185
product: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaM pd3 c
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false
name: Previtamin D3
is: HMDB06500
is: SBO:0000247
initial amount: NaN
type: Species

metaR r1656
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c1013c85_a9a4_4ca0_831b_f468983c8f07
initial concentration: NaN
is encoded by: hsa:100128062
constant: false
is: SBO:0000252
type: Species
name: _100128062_1_m
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0410
type: Reaction
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_8297ec3e_211a_4a70_890e_5a536d4bb5a6
is: B7Z5G2
has only substance units: false
is encoded by: hsa:2629
name: GBA
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR r2317
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_a8302b30_163b_4792_9796_50fe6db3c307
is: SBO:0000252
is: O15056
initial amount: NaN
constant: false
is encoded by: hsa:8871
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: SYNJ2

metaR C14STRr
kinetic law: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
name: C-14 sterol reductase
product: MODEL1310110019#
reversible: false
is: SBO:0000176
modifier: MODEL1310110019#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110019#

metaR r0838
product: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
name: Free diffusion
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false

metaM zym int2 r
boundary condition: false
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
is: SBO:0000247
constant: false
name: zymosterol intermediate 2
type: Species
is: CHEBI:52386
initial concentration: 1.0

metaR AATAi
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
modifier: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
name: 2-aminoadipate transaminase, irreversible
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
is: SBO:0000176

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
initial amount: NaN
type: Species
name: acetone
boundary condition: false
is: SBO:0000247
is: CHEBI:15347
has only substance units: false
is: HMDB01659
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7a5b2d90_8fa1_4b41_be4e_448cd3208821
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q6UWQ5
name: LYZL1
is encoded by: hsa:84569
type: Species
initial amount: NaN

metaR ILEtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110019#
reversible: true
is described by: ECO:0000269

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR r1659
reversible: true
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_80e5f54c_9ca0_476c_bdf9_2f15568d994c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q92947
is encoded by: hsa:2639
has only substance units: false
constant: false
name: GCDH
initial amount: NaN
type: Species

metaR ASNCYSNaEx
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110019#

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_4ab8023a_7d41_420e_b8ac_3767b0af6ff0
has only substance units: false
is encoded by: hsa:37
name: ACADVL
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P49748
type: Species
boundary condition: true
constant: false

metaM dttp c
name: dTTP
is: C00459
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01342
type: Species
is: CHEBI:37568
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaR RE1447M
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: RE1447
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d3b0a30b_2a0b_4e66_84b9_bfe2ff914bfc
has only substance units: false
is encoded by: hsa:AI539321
initial amount: NaN
name: _AI539321_1_c
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7274926a_b76a_4e9f_aa0a_7898b8aa68ed
type: Species
name: CMAS
is: SBO:0000252
is encoded by: hsa:55907
is: Q8NFW8
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM thbpt4acam n
has only substance units: false
constant: false
is: CHEBI:15374
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR r1658
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 44mzym r
is: SBO:0000247
is: HMDB01286
name: 14-demethyllanosterol
is: CHEBI:18364
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
initial amount: NaN

metaR r1578
product: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_9ef9ee9d_fe8e_4a9d_965d_8abe820ab9c4
initial amount: NaN
type: Species
is: O00330
boundary condition: true
is encoded by: hsa:8050
initial concentration: NaN
has only substance units: false
constant: false
name: PDHX
is: SBO:0000252

metaR 2OXOADOXm
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110019#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2

metaR r2319
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3fa62488_85fa_4d61_bcd0_1b543f225467
name: GSR
is encoded by: hsa:2936
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: P00390
constant: false
has only substance units: false

metaM icit m
type: Species
boundary condition: false
is: HMDB00193
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: C00311
is: CHEBI:16087
name: Isocitrate
initial concentration: 1.0

metaM cbasp e
type: Species
is: CHEBI:32814
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial amount: NaN
is: SBO:0000247
constant: false
name: N-Carbamoyl-L-aspartate
initial concentration: 1.0
is: HMDB00828
is: C00438

metaR PI45P5P
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is: SBO:0000176
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_de7bc492_292f_44cf_a366_c704c0337634
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: VNN1
initial amount: NaN
boundary condition: true
is encoded by: hsa:8876
is: SBO:0000252
is: O95497

http://identifiers.org/biomodels.db/MODEL1310110019#_0344c4ed_89c3_4f15_8b65_b2c469ac820a
has only substance units: false
is encoded by: hsa:2348
constant: false
is: SBO:0000252
initial amount: NaN
name: FOLR1
boundary condition: true
type: Species
initial concentration: NaN

metaM bilglcur c
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_7c4e0449_0858_4691_95d9_43c3abb2fb3c
type: Species
name: _AA854479_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA854479
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_942657f7_8d78_4ad9_bcf2_ab8731b195f0
type: Species
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
has part: P36957
is encoded by: hsa:1743
initial amount: NaN
has part: P09622
is: SBO:0000297
has only substance units: false
is encoded by: hsa:1738
constant: false
is encoded by: hsa:4967
has part: Q02218
has part: O00330
boundary condition: true
is encoded by: hsa:8050

metaM xmp c
is: C00655
type: Species
is: CHEBI:57464
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
name: Xanthosine 5'-phosphate
is: HMDB01554
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM dutp c
has only substance units: false
initial amount: NaN
type: Species
is: C00460
is: CHEBI:17625
initial concentration: 1.0
name: dUTP
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
is: SBO:0000247
is: HMDB01191

metaR r1928
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_98b21f36_ce25_47f3_8eba_d6472b61cb63
is: SBO:0000252
is encoded by: hsa:57835
name: SLC4A5
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9BY07
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_bf375a1a_2dd3_46c1_8aa6_4484b9907f27
constant: false
initial amount: NaN
is encoded by: hsa:4538
is: SBO:0000252
type: Species
is: P03905
initial concentration: NaN
name: ND4
boundary condition: true
has only substance units: false

metaM glyc R c
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16659
type: Species
is: HMDB00139
name: D-glycerate
initial concentration: 1.0
constant: false
initial amount: NaN

metaR PIter
is described by: ECO:0000212
is: SBO:0000185
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
name: phosphate transport, endoplasmic reticulum
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_9392a898_b72b_4238_a04c_2dcd48807372
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: PYCR2
boundary condition: true
is: Q96C36
initial amount: NaN
is encoded by: hsa:29920
constant: false

metaM lanost r
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: HMDB01251
name: lanosterol
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16521

http://identifiers.org/biomodels.db/MODEL1310110019#_dd60d5d2_aa7b_461d_b440_4a3a2948b19b
constant: false
initial concentration: NaN
name: _AI694761_1_c
is encoded by: hsa:AI694761
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1571
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000

metaR LPASE
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.5
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: false
name: lysophospholipase
fast: false
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110019#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_66d7e676_2004_4e36_986f_f1f8716c740f
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: GRHPR
constant: false
boundary condition: true
is: Q9UBQ7
is encoded by: hsa:9380
type: Species
is: SBO:0000252

metaR r1418
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110019#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_2ca58d4c_0de1_4c63_aaa4_01012bb670a0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8140
initial amount: NaN
is: SBO:0000252
type: Species
is: Q8IV97
constant: false
boundary condition: true
name: SLC7A5

http://identifiers.org/biomodels.db/MODEL1310110019#_c8290c6b_dbbb_4ba8_b1be_8e7557c46ef3
is: P21108
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PRPS1L1
constant: false
has only substance units: false
is encoded by: hsa:221823
initial amount: NaN

metaR MAL Ltx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
name: Transport reaction for malate
is described by: ECO:0000134
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110019#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_689209a6_ebe8_4eee_8e55_0c8ec392f5bb
boundary condition: true
has only substance units: false
is: B2RDU6
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4598
name: MVK

metaR RE3520E
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
name: RE3520
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
fast: false
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_cb9e34ea_1460_4cd5_93a6_dd6c07ce2ea0
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1103
has only substance units: false
is: P28329
name: CHAT

metaM cdp n
is: CHEBI:58069
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
initial concentration: 1.0
is: HMDB01546
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaM dnad c
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:18304
name: Deamino-NAD+
is: C00857
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaM dtmp m
is: SBO:0000247
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
type: Species
is: CHEBI:26999
boundary condition: false
has only substance units: false
name: dTMP
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 2oxoadp c
type: Species
name: 2-oxoadipate(2-)
is: CHEBI:57499
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR BDHm
is described by: ECO:0000269
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
reversible: true
is: SBO:0000176

metaM 5pmev c
initial concentration: 1.0
is: HMDB01343
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
initial amount: NaN
has only substance units: false
name: (R)-5-phosphonatomevalonate(3-)
is: SBO:0000247

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3fe465c0_4c48_4e61_93b1_b657dc525ce8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PLCE1
initial amount: NaN
is: Q9P212
constant: false
has only substance units: false
type: Species
is encoded by: hsa:51196

metaR DCYTD
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110019#
type: Reaction
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
is described by: ECO:0000254
reversible: false
name: deoxycytidine deaminase

metaR r0488
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
product: MODEL1310110019#
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
kinetic law: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
fast: false
type: Reaction

metaM trdrd m
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Reduced thioredoxin
type: Species
is: CHEBI:15967
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_dc276273_e9a3_4c8a_8287_1c4675cdcfcb
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: SLC25A2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:83884
is: Q9BXI2

metaR r1573
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dudp n
boundary condition: false
initial amount: NaN
type: Species
name: dUDP(3-)
has only substance units: false
is: CHEBI:60471
initial concentration: 1.0
is: HMDB01000
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaM glyald m
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: D-glyceraldehyde
is: CHEBI:17378
has only substance units: false
is: HMDB01051
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaR THRASNNaEx
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110019#
is: SBO:0000185
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM 10fthf5glu e
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
boundary condition: false
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN
is: HMDB00108
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16236

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: SBO:0000247
type: Species
name: O2
constant: false
is: CHEBI:15379
is: C00007
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01377

metaR 3MOBte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
is: SBO:0000185

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR GGT5r
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
product: MODEL1310110019#
name: Gamma-glutamyltransferase 5
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: true
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_5a87727e_fc8c_4af9_9f81_cfeddf6bc3ee
is: Q9NUB1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:84532
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: ACSS1

metaM L2aadp m
is: HMDB00510
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58672
is: SBO:0000247
initial concentration: 1.0
name: L-2-aminoadipate(1-)
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaM itp n
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
name: ITP(3-)
constant: false
is: HMDB00189
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM dttp n
is: CHEBI:37568
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
name: dTTP
is: C00459
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_85b3c04e_eade_45c9_9bd0_c102cdfbc21e
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: BLVRA
is: P53004
constant: false
is encoded by: hsa:644
boundary condition: true
is: SBO:0000252

metaR RE3556C
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3556
product: MODEL1310110019#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_db69526d_cf51_43d4_9bac_fc46603a642c
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:223
has only substance units: false
name: ALDH9A1
initial amount: NaN
constant: false
is: P49189
is: SBO:0000252

metaR r1574
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_e2290963_0e19_4c4c_a206_b5ac8b463ba7
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM for c
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
initial concentration: 1.0
name: Formate
has only substance units: false
is: CHEBI:15740
is: HMDB00142
is: C00058
type: Species

metaM CE5236 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
is: HMDB03952
boundary condition: false
initial amount: NaN
is: CHEBI:28002
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false

metaM pan4p m
is: CHEBI:47942
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01416

http://identifiers.org/biomodels.db/MODEL1310110019#_95e17bf8_f066_44ff_8792_cb4de5b73ee4
name: CDA
initial concentration: NaN
is encoded by: hsa:978
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P32320
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3712f329_1966_4cc8_aa03_92de889306b4
constant: false
type: Species
is encoded by: hsa:51727
is: SBO:0000252
name: CMPK1
boundary condition: true
has only substance units: false
is: B2R6S5
initial amount: NaN
initial concentration: NaN

metaR r0774
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_ceba1d31_3738_4993_85ba_1b62850a5292
has only substance units: false
type: Species
is encoded by: hsa:1103
initial amount: NaN
is: Q6LEN6
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110019#_ac459127_84d3_4fcb_9bf5_ff6426124042
is: SBO:0000252
type: Species
is: Q14916
is encoded by: hsa:6568
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC17A1

metaR GALU
reactant: MODEL1310110019#
name: UTP-glucose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reversible: true
type: Reaction
is described by: ECO:0000134
fast: false

metaM dudp m
initial amount: NaN
is: SBO:0000247
constant: false
name: dUDP(3-)
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
is: HMDB01000
initial concentration: 1.0
type: Species
is: CHEBI:60471

metaM stcoa x
is: CHEBI:57394
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
has only substance units: false
constant: false
initial amount: NaN
is: C00412
is: HMDB01114

http://identifiers.org/biomodels.db/MODEL1310110019#_05a932c6_5bb0_4070_8b76_d79840416c17
is encoded by: hsa:5331
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PLCB3
is: G5E960

http://identifiers.org/biomodels.db/MODEL1310110019#_563470e4_acee_4186_8681_e422e59ecc43
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4258
is: D6RBB5
constant: false
name: MGST2
initial concentration: NaN
type: Species
has only substance units: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM dhcholestanate m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
is: CHEBI:16577
type: Species
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_1fc8878d_4663_4c2f_a3b5_6b59558f4763
type: Species
constant: false
has only substance units: false
is: E5KS60
initial concentration: NaN
name: SUCLA2
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8803

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR r2310
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
product: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_ad9a0b83_58d1_4f0f_94f5_8dfd656f9cb1
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC24A4
is encoded by: hsa:123041
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_69aa2867_a589_40f0_ba1f_53b1d0106783
boundary condition: true
type: Species
is: Q9NVE7
initial concentration: NaN
name: PANK4
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:55229

metaR MGCHrm
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is described by: ECO:0000269
reversible: true

metaR FRDPtc
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport

metaM leuktrE4 e
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
constant: false
has only substance units: false
name: leukotriene E4(1-)

metaR r0779
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110019#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR ECOAH1m
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110019#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM forglu c
has only substance units: false
is: C00439
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:18327
name: N-Formimidoyl-L-glutamate
constant: false
is: HMDB00854
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: SBO:0000247

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM o2 e
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01377
constant: false
is: C00007
is: CHEBI:15379

metaR RE3626M
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110019#
name: RE3626
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_642587d3_85a3_4016_95e3_091be1c182ae
initial concentration: NaN
is encoded by: hsa:11332
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACOT7
is: O00154
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_fe7d12c1_f328_4e2a_9019_2d69f51c154d
name: ALDOA
has only substance units: false
type: Species
constant: false
is encoded by: hsa:226
is: P04075
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR CMPSASn
type: Reaction
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.7.43
name: CMP sialic acid synthase, nuclear
product: MODEL1310110019#
reversible: false

metaR HMGCOASim
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction
reversible: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_066ee91f_bc01_471c_a76e_ec036126067d
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9H310
name: RHBG
constant: false
is encoded by: hsa:57127
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_17459720_9d1f_4ecf_a6ae_1c4fde623ace
has part: P48728
has part: P23434
initial concentration: NaN
is: SBO:0000297
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2731
constant: false
boundary condition: true
is encoded by: hsa:2653
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:275
has part: P23378

metaM 56dura c
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 5,6-dihydrouracil
is: HMDB00076
is: SBO:0000247
is: CHEBI:15901
has only substance units: false
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d75c66e9_487e_4881_818c_900d495d78c9
initial concentration: NaN
name: NT5E
is encoded by: hsa:4907
initial amount: NaN
is: P21589
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM dadp n
is: HMDB01508
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
has only substance units: false
name: dADP(3-)
boundary condition: false
type: Species
is: CHEBI:57667

http://identifiers.org/biomodels.db/MODEL1310110019#_f5736ca7_d580_4347_91bf_78486d8377f5
has only substance units: false
type: Species
is encoded by: hsa:H17063
constant: false
name: _H17063_1_m
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM itacon m
initial concentration: 1.0
type: Species
is: HMDB02092
boundary condition: false
constant: false
name: itaconate(2-)
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: SBO:0000247
is: CHEBI:17240
initial amount: NaN

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
is described by: ECO:0000269
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110019#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110019#

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110019#
fast: false
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM leuktrE4 c
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
has only substance units: false
name: leukotriene E4(1-)
is: HMDB02200
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_4e8d52a3_1ed3_4a75_b33e_2be7555e9dbf
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: E9PB82
name: HSD17B4
is: SBO:0000252
constant: false
is encoded by: hsa:3295
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_79e752a4_68ff_4333_a2ac_8647f5477e34
is encoded by: hsa:AA081045
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: _AA081045_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_38311396_3ccd_4ba2_b685_68ed596cee0b
is: O95477
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:19
initial amount: NaN
name: ABCA1
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_46d2b29d_5271_4ad1_9015_06581c90c1f8
is: D9HTE9
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC25A1
is encoded by: hsa:6576
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e5a0f0ea_9a40_420e_b049_c2eae37eb67b
is encoded by: hsa:4514
constant: false
is: P00414
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: COX3
boundary condition: true

metaR LYStiDF
product: MODEL1310110019#
reactant: MODEL1310110019#
name: L-lysine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_87cd1de5_9ee2_4e9f_838c_8cd489a206ba
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B7Z5T8
type: Species
is: SBO:0000252
has only substance units: false
name: CPT1B
constant: false
is encoded by: hsa:1375

http://identifiers.org/biomodels.db/MODEL1310110019#_96172761_aa4e_4ecc_b4b2_4d56474b6b48
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23517
is: Q3MHC9
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: SKIV2L2

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaM dadp m
type: Species
boundary condition: false
name: dADP(3-)
is: CHEBI:57667
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508

metaR r2311
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_1b4a8b5a_0243_4337_9b7e_0124e2e3df9a
is: A8K3L7
constant: false
initial concentration: NaN
is encoded by: hsa:10423
is: SBO:0000252
name: CDIPT
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaM h2o2 c
is: C00027
name: Hydrogen peroxide
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
type: Species
is: HMDB03125
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
boundary condition: false

metaR TCYNTtm
type: Reaction
reversible: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
name: Thiocyanate transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_76286635_d46c_43a1_b452_3cdfae29fe4c
type: Species
boundary condition: true
is: SBO:0000252
name: UGP2
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q16851
is encoded by: hsa:7360

metaR r1570
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true

metaM dhbpt c
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:20680
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
type: Species
name: 6,7-dihydrobiopterin
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR NTD9
is described by: ECO:0000134
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
name: 5'-nucleotidase (GMP)
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: false
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR RE0935E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0935
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110019#
fast: false
reversible: true
type: Reaction

metaM ps hs c
is: CHEBI:18303
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: ps_hs[c]
type: Species
has only substance units: false

metaR Uritm
is described by: ECO:0000269
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reversible: true
is: SBO:0000185
name: uridine facilated transport in mitochondria
reactant: MODEL1310110019#

metaR GLYOp
type: Reaction
reactant: MODEL1310110019#
name: glycine oxidase, perixosomal
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r0552
modifier: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaR LEUTA
modifier: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
fast: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110019#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110019#
name: leucine transaminase

metaM h2o2 e
initial amount: NaN
is: HMDB03125
name: hydrogen peroxide
has only substance units: false
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
boundary condition: false
type: Species

metaM cit m
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Citrate
is: CHEBI:16947
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110019#_dabd7010_0880_4ce3_9fbb_1e80ea19163b
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q96QE2
initial concentration: NaN
name: SLC2A13
is encoded by: hsa:114134

metaR RE2541E
product: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
name: RE2541
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaR DAGK hs
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
reversible: true
reactant: MODEL1310110019#
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110019#

metaR r0558
modifier: MODEL1310110019#
fast: false
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110019#

metaM nicrnt c
type: Species
constant: false
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57502
is: SBO:0000247
name: Nicotinate D-ribonucleotide

metaM e4hglu m
name: erythro-4-hydroxy-L-glutamate(1-)
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB02273
is: CHEBI:6331

metaM prostgd2 r
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57406
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
has only substance units: false
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110019#_75e135d3_3fae_4452_b778_4166acd09585
is: P27708
name: CAD
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:790
constant: false
boundary condition: true
has only substance units: false

metaM succ m
is: SBO:0000247
name: Succinate
has only substance units: false
is: CHEBI:30031
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: C00042

http://identifiers.org/biomodels.db/MODEL1310110019#_e8efbdae_346c_4559_9d77_8824452a7243
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2629
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: GBA
is: B7Z6S9

http://identifiers.org/biomodels.db/MODEL1310110019#_3fa89dfe_be20_4022_a567_91bda8677209
is: O43181
type: Species
is: SBO:0000252
is encoded by: hsa:4724
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: NDUFS4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e7d89eee_2e12_4a5c_8834_a89f12170d58
initial amount: NaN
initial concentration: NaN
is: O00624
name: SLC17A2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:10246
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_562a8017_aa22_4e19_8ed2_3982d9357c93
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4710
has only substance units: false
is: O95168
type: Species
name: NDUFB4

metaM accoa r
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01206
boundary condition: false
is: SBO:0000247
name: acetyl-CoA(4-)
constant: false
has only substance units: false
is: CHEBI:57288

metaR r0268
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176

metaM 3mob e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial amount: NaN
type: Species
is: CHEBI:11851
constant: false
name: 3-methyl-2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110019#_6070103d_74c4_4b22_adf4_b1bc8372db1c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q7Z4L0
constant: false
has only substance units: false
is encoded by: hsa:341947
boundary condition: true
type: Species
name: COX8C

metaM 2oxoadp m
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
type: Species
is: CHEBI:57499
has only substance units: false
boundary condition: false
constant: false
is: HMDB00225
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r1932
product: MODEL1310110019#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
name: Y+LAT2 Utilized transport
type: Reaction

metaR PE HStm
reversible: true
fast: false
type: Reaction
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR CREATt4 2 r
name: Creatine transport (sodium symport) (2:1)
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110019#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_d6ea9e93_c5f1_44fa_bc0c_fbff3ead57c6
is: G3V4L5
is encoded by: hsa:89874
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC25A21
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_38804097_0772_4345_87c4_c7eac5ff77f7
name: _H77542_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:H77542

metaR r2389
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000

metaR RTOTALt
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
is: SBO:0000185

metaR RE1532M
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110019#
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3702c1d9_23d4_4802_b2e3_5870f245bfbb
has only substance units: false
is encoded by: hsa:AI291895
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AI291895_1_c

metaR r1933
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#

metaR r0556
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110019#

metaR r2065
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM lnlc r
constant: false
is: SBO:0000247
initial amount: NaN
name: linoleate
type: Species
boundary condition: false
is: HMDB00673
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0
has only substance units: false

metaM gar c
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
constant: false
initial concentration: 1.0
is: C03838
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: HMDB02022
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58457
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0524723a_736b_4edb_b269_526a92696291
type: Species
boundary condition: true
name: _AL525798_1_c
is encoded by: hsa:AL525798
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR CO2tm
type: Reaction
kinetic law: MODEL1310110019#
fast: false
name: CO2 transport (diffusion), mitochondrial
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110019#
is described by: ECO:0000000

metaM cgly e
is: CHEBI:4047
name: L-cysteinylglycine
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: SBO:0000247
is: HMDB00078

metaR r1934
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110019#_cb4b4af6_b125_4933_a2b2_2586aa02deae
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM ppi c
type: Species
is: SBO:0000247
name: Diphosphate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
boundary condition: false
has only substance units: false
is: HMDB00250
constant: false
is: C00013
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110019#_68194464_64be_4806_9650_8bb9519ee2bc
is: SBO:0000252
is encoded by: hsa:65010
name: SLC26A6
is: Q9NQU1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaM dag hs e
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
name: diglyceride
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:18035

http://identifiers.org/biomodels.db/MODEL1310110019#_fde0cb5c_e888_4242_ac55_66ef3b9ced75
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: B3KT70
has only substance units: false
is encoded by: hsa:80201
boundary condition: true
name: HKDC1

metaR PRISTCOAtcx
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_c83f10af_9f98_470c_a2e6_14f65f88bf2a
is: O95139
initial concentration: NaN
type: Species
is: SBO:0000252
name: NDUFB6
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4712
has only substance units: false

metaM C02528 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00518
type: Species
name: chenodeoxycholate
is: CHEBI:36234

metaM urate e
name: Urate
is: CHEBI:17775
has only substance units: false
is: C00366
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB00289
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR GLUPROASCT1
reversible: false
is: SBO:0000185
type: Reaction
name: glutamate intake by system ASCT-1 transporter
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
product: MODEL1310110019#
fast: false
is described by: ECO:0000134
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaM mercplac c
initial concentration: 1.0
name: 3-Mercaptolactate
initial amount: NaN
type: Species
is: HMDB02127
has only substance units: false
is: http://identifiers.org/pubchem.compound/8118
boundary condition: false
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
constant: false
is: C05823
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_c35bc8ae_bd48_4181_881a_160891619311
type: Species
boundary condition: true
name: NDUFA8
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4702
initial amount: NaN
is: B1AM93
initial concentration: NaN

metaR NP1
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: nucleotide phosphatase
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_eea3766c_02ef_4238_9d5a_01fdd9c155e4
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O75452
is encoded by: hsa:8608
initial concentration: NaN
name: RDH16
boundary condition: true

metaR r0033
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
type: Reaction

metaM accoa m
initial amount: NaN
is: CHEBI:57288
constant: false
name: Acetyl-CoA
has only substance units: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
type: Species
is: C00024
is: SBO:0000247
initial concentration: 1.0

metaR DTDPtn
name: dTDP nuclear transport
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000

metaR ADEt
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110019#
name: adenine reversible transport, cytosol
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_72180501_e777_4879_ad7b_29aa24b69bd2
type: Species
is: Q9Y2D0
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11238
is: SBO:0000252
has only substance units: false
name: CA5B
initial amount: NaN

metaM dag hs c
is: CHEBI:18035
is: SBO:0000247
has only substance units: false
name: diglyceride
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_86c3e0a5_78c1_4d2b_9da8_03f20ab061e2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:206358
is: Q1LZ56
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC36A1

metaR GGH 10FTHF7GLUe
fast: false
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM pheacgln c
is: SBO:0000247
type: Species
is: CHEBI:58310
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344

metaM udpg r
initial concentration: 1.0
is: HMDB00286
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:58367
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaM ppi e
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
name: Diphosphate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: CHEBI:33019
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110019#_5603b162_f14e_4334_8cac_eec996257cb1
is encoded by: hsa:57379
has only substance units: false
initial amount: NaN
is: Q546Y9
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: AICDA

metaM accoa n
is: HMDB01206
name: acetyl-CoA(4-)
has only substance units: false
is: CHEBI:57288
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_a8dde2d6_6ed4_4e56_8540_7425277815f5
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: PIP5K1A
boundary condition: true
is encoded by: hsa:8394
is: Q99755
has only substance units: false

metaM cgly c
name: L-cysteinylglycine
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
constant: false
is: HMDB00078
initial amount: NaN
type: Species

metaM aacoa c
is: HMDB01484
initial concentration: 1.0
type: Species
is: C00332
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: Acetoacetyl-CoA
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286
initial amount: NaN

metaM HC01118 r
boundary condition: false
name: presqualene diphosphate(3-)
is: CHEBI:57310
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_04223bd5_23ff_4bc2_bd6c_4bc403d1dae7
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q16873
name: LTC4S
is encoded by: hsa:4056
initial amount: NaN

metaR LNLCCRNt
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
name: transport into the mitochondria (carnitine)

metaM crm hs g
is: SBO:0000247
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
initial amount: NaN
is: CHEBI:52639
initial concentration: 1.0
boundary condition: false
name: N-acylsphingosine
has only substance units: false

metaR PAIL45P HStn
kinetic law: MODEL1310110019#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaR THRSERNaEx
type: Reaction
reversible: false
modifier: MODEL1310110019#
product: MODEL1310110019#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
is: SBO:0000185

metaR GLNTHRNaEx
kinetic law: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
fast: false
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
reversible: false
modifier: MODEL1310110019#

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR ALATHRNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110019#
reversible: false
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110019#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_27fb5fa5_fd5d_427d_96df_a65932062573
initial amount: NaN
is encoded by: hsa:9651
is: O75038
has only substance units: false
is: SBO:0000252
name: PLCH2
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM dhcholestanate c
initial amount: NaN
is: CHEBI:16577
type: Species
is: HMDB00359
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false

metaR ALACYSNaEx
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110019#

metaR HMGCOAtm
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_fa8e3e22_3b3e_47d2_913c_92dd63989a16
type: Species
is: B4DIA3
has only substance units: false
is encoded by: hsa:6535
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SLC6A8

metaR PROSTGE1t
kinetic law: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
name: prostaglandin transport via bicarbonate countertransport
fast: false
reversible: true
type: Reaction

metaR ASPPROASCT1
name: aspartate intake by system ASCT-1 transporter
type: Reaction
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_e108522f_1c9e_4aae_8133_8e655dc1c541
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: HAO2
has only substance units: false
is: Q9NYQ3
constant: false
initial concentration: NaN
is encoded by: hsa:51179

metaM xan c
is: SBO:0000247
is: HMDB00292
initial amount: NaN
constant: false
is: C00385
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
name: Xanthine
boundary condition: false
is: CHEBI:17712
type: Species

metaM urate c
type: Species
constant: false
initial concentration: 1.0
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:17775
is: C00366
boundary condition: false
name: Urate

http://identifiers.org/biomodels.db/MODEL1310110019#_e24ec303_7e16_4545_b1ab_2c2ee1de29a7
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: NDUFV3
has only substance units: false
is encoded by: hsa:4731
is: SBO:0000252
initial amount: NaN

metaM pail45p hs m
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28910
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_ad77f8d9_62be_49b4_9ae7_f69a3d8015f5
is: SBO:0000252
constant: false
initial concentration: NaN
name: CMPK1
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51727
is: B2R6S5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_4ed925c6_8451_4e77_90ce_3b18ea0eb5fa
name: _AI824319_1_r
is encoded by: hsa:AI824319
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR r0559
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
type: Reaction
modifier: MODEL1310110019#

metaR R group phosphotase 1
product: MODEL1310110019#
type: Reaction
name: R group phosphotase 1
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
reversible: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR ALAASNNaEx
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000269
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
reversible: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
is: CHEBI:57767
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_604d7767_a853_49c2_89e9_dff910270223
type: Species
is encoded by: hsa:8802
is: SBO:0000252
boundary condition: true
name: SUCLG1
initial amount: NaN
constant: false
is: P53597
has only substance units: false
initial concentration: NaN

metaR NDPK10n
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus

metaM udp c
is: CHEBI:58223
type: Species
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00015

metaM pail45p hs n
is: CHEBI:28910
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR RE1691M
is version of: http://identifiers.org/ec-code/2.8.1.1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true
name: RE1691
is described by: ECO:0000000
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_03223060_610c_4241_bc90_8a5f98f86c46
is: E9KL48
name: GLUD1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2746
initial amount: NaN

metaR NDPK7n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
product: MODEL1310110019#
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR GLYCt
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110019#
name: glycerol transport via channel
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110019#

metaR r2200
type: Reaction
fast: false
modifier: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_ff11906c_fc81_4e91_8160_ed08b3d2f34e
has only substance units: false
constant: false
name: UCK1
is encoded by: hsa:83549
is: Q5JT09
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR PYRt2r
is described by: ECO:0000269
name: pyruvate reversible transport via proton symport
reversible: true
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction

metaM pail45p hs c
initial concentration: 1.0
boundary condition: false
is: CHEBI:28910
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
type: Species

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110019#
name: UMP kinase (CTP),nuclear
reversible: true
modifier: MODEL1310110019#

metaM gam c
is: HMDB01514
is: SBO:0000247
is: CHEBI:17315
initial concentration: 1.0
constant: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: C00329
name: D-Glucosamine
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR ACACtx
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
name: acetoacetate intracellular transport unknown mechanism
product: MODEL1310110019#
reversible: true

metaM for r
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: Formate
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
has only substance units: false
is: HMDB00142
is: C00058

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#

metaM phaccoa c
is: HMDB06503
boundary condition: false
name: phenylacetyl-CoA(4-)
constant: false
is: CHEBI:57390
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
type: Species
initial concentration: 1.0
has only substance units: false

metaM cit e
is: HMDB00094
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
constant: false
is: CHEBI:16947
type: Species
name: citrate(3-)
has only substance units: false
boundary condition: false
initial amount: NaN

metaM o2 r
boundary condition: false
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15379
name: O2
type: Species
constant: false
is: C00007
initial amount: NaN
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110019#_471e3ef4_06ba_4d38_8939_e3e6e6356ea6
initial amount: NaN
name: AMY1A
constant: false
initial concentration: NaN
boundary condition: true
is: Q6NSB3
is encoded by: hsa:276
type: Species
is: SBO:0000252
has only substance units: false

metaM h2o2 m
name: Hydrogen peroxide
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB03125
type: Species
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: CHEBI:16240
initial amount: NaN
is: C00027

metaM 3php c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:18110
boundary condition: false
name: 3-phosphonatooxypyruvate(3-)
is: HMDB01024
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232

http://identifiers.org/biomodels.db/MODEL1310110019#_d29f8c09_3408_429e_8fe2_466edc786e3d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27124
boundary condition: true
name: INPP5J
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR ALAGLNNaEx
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000269
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110019#

metaR r1652
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaR ASNALANaEx
is: SBO:0000185
product: MODEL1310110019#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110019#
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#

metaR PLA2 2e
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
name: phospholipase A2
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.4
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaR r2201
reversible: true
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185

metaR TYROXDAc
reversible: false
product: MODEL1310110019#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)

metaM crm hs c
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: N-acylsphingosine
constant: false

metaM dcholcoa c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: HMDB06292
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_256cbf56_cbb1_4a9f_b0ec_4ee58ac331ad
is encoded by: hsa:10166
has only substance units: false
is: SBO:0000252
type: Species
is: Q9Y619
constant: false
initial concentration: NaN
boundary condition: true
name: SLC25A15
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_bef52698_b7c9_49c9_aee1_e41fa49cc5e7
is: SBO:0000252
initial amount: NaN
is: P14672
has only substance units: false
constant: false
name: SLC2A4
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6517

http://identifiers.org/biomodels.db/MODEL1310110019#_68bfab83_0637_4c5f_aca7_600934194a99
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P19634
is encoded by: hsa:6548
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC9A1

http://identifiers.org/biomodels.db/MODEL1310110019#_db11ea8f_8e7f_4068_bea6_82ebe584c2ac
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: DDO
boundary condition: true
is encoded by: hsa:8528
initial amount: NaN

metaM 3mob m
is: HMDB00019
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
has only substance units: false

metaM udp e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58223
is: HMDB00295
has only substance units: false
type: Species
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
constant: false

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR r1653
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110019#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_196186b3_2065_4476_becc_5f1cfaef6180
is encoded by: hsa:58510
initial concentration: NaN
is: Q9UF12
name: PRODH2
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM xol7a r
is: HMDB01496
name: 20-hydroxycholesterol
initial amount: NaN
constant: false
is: CHEBI:1296
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
type: Species
has only substance units: false

metaM gam e
is: CHEBI:17315
constant: false
is: C00329
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01514
is: SBO:0000247

metaR ALAGLNexR
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#

metaR DNDPt15m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via dGDP antiport
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_b19db35d_ba7d_4231_b849_4875ee9f25da
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:230
has only substance units: false
name: ALDOC
is: P09972
initial concentration: NaN
type: Species

metaR r2202
fast: false
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_e68ba2a2_8b1c_4996_98c6_1dd8acb9f1e6
initial amount: NaN
has only substance units: false
name: PLCG2
is: P16885
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:5336
boundary condition: true

metaM taur e
is: CHEBI:3544
constant: false
type: Species
is: HMDB00251
name: Taurine
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
is: C00245
initial concentration: 1.0

metaR UPP3S
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.75
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
reversible: false
reactant: MODEL1310110019#
name: uroporphyrinogen-III synthase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
type: Reaction

metaR r1654
reversible: true
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR LEUKTRA4t
name: leukotriene A4 transport
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaM cit c
is: C00158
is: HMDB00094
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
has only substance units: false
is: CHEBI:16947
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: Citrate

http://identifiers.org/biomodels.db/MODEL1310110019#_0c2e8e6b_d4d1_4ade_a2ea_3ee98c0f069c
initial amount: NaN
is: P08237
is encoded by: hsa:5213
has only substance units: false
type: Species
boundary condition: true
name: PFKM
initial concentration: NaN
constant: false
is: SBO:0000252

metaR MEVK1c
reversible: false
name: mevalonate kinase (atp) cytosol
type: Reaction
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
modifier: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d828bde8_ff55_44ea_9153_1f32f188b82d
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q99643
is: SBO:0000252
type: Species
is encoded by: hsa:6391
name: SDHC

metaM spmd c
type: Species
is: HMDB01257
is: C00315
name: Spermidine
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57834
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0

metaM pchol hs r
type: Species
is: CHEBI:16110
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: Phosphatidylcholine
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_94b50f99_ed07_4150_b789_d3c7bd94e497
is: O43674
name: NDUFB5
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:4711
is: SBO:0000252

metaR RDH1a
is version of: http://identifiers.org/ec-code/1.1.1.300
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
name: retinol dehydrogenase (all-trans,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110019#_88bf6904_7406_45fe_83b0_b076e4636ff0
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4731
initial amount: NaN
boundary condition: true
is: P56181
is: SBO:0000252
name: NDUFV3

http://identifiers.org/biomodels.db/MODEL1310110019#_90db3178_d396_4f02_af7c_ed74c6a7a7f2
type: Species
initial amount: NaN
name: SOD2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P04179
is encoded by: hsa:6648
constant: false

metaR FRDPtr
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_085545db_4e06_42f0_bbb0_1f9f27ce39b2
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23428
initial amount: NaN
name: SLC7A8
initial concentration: NaN
is: Q9UHI5
constant: false

metaM crm hs e
is: SBO:0000247
is: CHEBI:52639
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
boundary condition: false
type: Species
name: N-acylsphingosine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_5577752b_f761_4765_804b_0f2e297f794a
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:80025
name: PANK2
is: Q9BZ23

http://identifiers.org/biomodels.db/MODEL1310110019#_5207f2e1_0fa6_437d_acbe_9d7fc5606982
has only substance units: false
name: _7359_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:7359
initial concentration: NaN

metaR DALAt2r
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000304
name: D-alanine transport via proton symport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM f1p c
has only substance units: false
name: D-Fructose 1-phosphate
is: C01094
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:18105
is: SBO:0000247
is: HMDB01076
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
initial amount: NaN
boundary condition: false

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110019#
name: Transport of q10
type: Reaction
reactant: MODEL1310110019#

metaR MAL Lte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000134
reversible: true
type: Reaction
is: SBO:0000185
name: Transport of L-malate
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0d8a0dac_f44e_4114_9794_00fdbf607b6d
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: SLC4A8
constant: false
is: E7EML0
is: SBO:0000252
is encoded by: hsa:9498
initial amount: NaN

metaR r1655
modifier: MODEL1310110019#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#

metaM udp g
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0
is: HMDB00295
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: UDP(3-)
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM taur c
is: HMDB00251
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: Taurine
is: C00245
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
is: CHEBI:3544

http://identifiers.org/biomodels.db/MODEL1310110019#_384a293a_4b42_47ff_84de_4732c754b8ac
name: ACAA2
has only substance units: false
is: P42765
is: SBO:0000252
is encoded by: hsa:10449
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM 5HPET c
has only substance units: false
name: 5(S)-HPETE(1-)
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
is: HMDB01193
initial concentration: 1.0
is: CHEBI:57450
initial amount: NaN
boundary condition: false
constant: false

metaR H2Oter
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O endoplasmic reticulum transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#

metaM pcrn c
name: propionyl-carnitine
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaM accoa x
is: C00024
is: CHEBI:57288
name: Acetyl-CoA
boundary condition: false
constant: false
is: HMDB01206
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM thbpt4acam c
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: HMDB02281
initial concentration: 1.0

metaR CYOOm3
product: MODEL1310110019#
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
reversible: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.9.3.1

http://identifiers.org/biomodels.db/MODEL1310110019#_a4e64460_5cfc_471a_af98_b120efcccb28
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: TPI1P2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:286016
initial amount: NaN

metaR ALCD2yf
reversible: false
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000134
product: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false

metaM CE5236 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28002
has only substance units: false
type: Species

metaR HMGCOAtx
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_58fbc7f6_a731_4fc5_a40f_cbcdb3e675f1
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: P23919
is: SBO:0000252
is encoded by: hsa:1841
constant: false
has only substance units: false
name: DTYMK

metaM ac m
boundary condition: false
has only substance units: false
is: HMDB00042
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:30089
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110019#_479df5a8_9261_4494_92db_2e9bff8efc10
is: Q9BV79
constant: false
initial concentration: NaN
boundary condition: true
name: MECR
is: SBO:0000252
is encoded by: hsa:51102
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_19bd02b5_4c6f_42bf_8310_750489911f88
type: Species
is encoded by: hsa:622
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: BDH1

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
name: Propenoyl-CoA hydrolase (m)
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110019#_e3c554b5_c011_4631_ba99_98901cd9ba4f
is: SBO:0000252
initial amount: NaN
name: RPE
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6120
has only substance units: false
is: Q53TV9
type: Species
constant: false

metaR r0842
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM fru e
is: HMDB00660
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: SBO:0000247
is: CHEBI:15824
constant: false
name: D-Fructose
type: Species
initial amount: NaN
has only substance units: false
is: C00095
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_0d30663d_a912_4723_9689_0ad5d28d746c
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8836
is: Q92820
name: GGH

metaM 1pyr5c c
initial concentration: 1.0
constant: false
is: C03912
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
is: HMDB01301
is: SBO:0000247
type: Species
has only substance units: false

metaM L2aadp c
is: HMDB00510
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-2-aminoadipate(1-)
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR CYTK12n
reversible: true
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_87bc01ad_a908_4cc4_b37d_100c1af48fe5
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: SLC23A1
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:9963

metaM prostgd2 e
type: Species
is: SBO:0000247
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01403
name: prostaglandin D2(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_4254e150_2c0d_43d9_8834_70dd60424622
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: Q16790
name: CA9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:768

metaR FATP2t
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
modifier: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
name: fatty acid electroneutral transport
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_644bdcb0_5489_446b_a72b_844db1f0a225
is: E5KSL6
is encoded by: hsa:1716
initial concentration: NaN
is: SBO:0000252
name: DGUOK
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_de3e8d7b_3363_4436_b423_4560621c6250
boundary condition: true
is: P28331
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4719
name: NDUFS1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_abe1f429_335a_4132_8134_e807278e9bbe
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFA3
is: O95167
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4696

W3 CDTF: Fri Aug 31 06:19:08 BST 2012

metaM for m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
type: Species
name: formate
is: HMDB00142

metaR PYRt2m
name: pyruvate mitochondrial transport via proton symport
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reactant: MODEL1310110019#
fast: false
type: Reaction

metaR RE1526M
product: MODEL1310110019#
type: Reaction
reversible: true
fast: false
name: RE1526
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_535b35b8_5366_479e_ae41_4596a0183641
has only substance units: false
is: SBO:0000252
is: P06132
boundary condition: true
constant: false
type: Species
name: UROD
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7389

metaR C4STMO2r
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: C-4 methyl sterol oxidase
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.72
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176

metaM CE0785 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57795
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: cis,cis-myristo-5,8-dienoyl-CoA

metaM lnlc e
is: SBO:0000247
is: CHEBI:30245
name: linoleate
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_53246f8e_8f9a_4281_b107_485f865b1cb6
is: SBO:0000252
type: Species
is: Q6IBK2
initial concentration: NaN
has only substance units: false
name: KHK
is encoded by: hsa:3795
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ab3448c7_d815_468b_ab7b_6adbfdbd7137
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:R39999
name: _R39999_1_c
initial amount: NaN
initial concentration: NaN
constant: false

metaM cholp g
is: C00588
is: SBO:0000247
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:295975
name: choline phosphate(1-)
boundary condition: false
has only substance units: false
constant: false

metaM dtmp c
type: Species
is: C00364
boundary condition: false
constant: false
has only substance units: false
is: HMDB01227
initial concentration: 1.0
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
is: SBO:0000247
is: CHEBI:26999

metaR PROSTGF2t
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
product: MODEL1310110019#
name: prostaglandin uniport
type: Reaction
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_29fb6e31_1c58_4daf_a3e1_3251a2dc682d
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: _R06874_1_r
boundary condition: true
has only substance units: false
is encoded by: hsa:R06874

metaR CYTK8n
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110019#
name: cytidylate kinase (CMP,dATP),nuclear
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e66b881a_765b_4215_8532_2c0d6181924e
is: SBO:0000252
is encoded by: hsa:9107
is: Q9Y217
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: MTMR6

http://identifiers.org/biomodels.db/MODEL1310110019#_2c549b4a_3062_45bf_abb2_0ae24024537b
is encoded by: hsa:219
has only substance units: false
boundary condition: true
name: ALDH1B1
is: P30837
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR P5CRxm
name: pyrroline-5-carboxylate reductase (m)
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r2069
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaR PROt2r
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: L-proline reversible transport via proton symport
is: SBO:0000185
product: MODEL1310110019#

metaM HC01522 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28508
name: Gentisate aldehyde
constant: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
has only substance units: false
type: Species

W3 CDTF: Fri Aug 31 06:19:08 BST 2012

metaR ARACHDCOAtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110019#_67f22c90_bca2_4e38_b1ff_fc2a02042c37
initial concentration: NaN
is encoded by: hsa:3157
constant: false
initial amount: NaN
name: HMGCS1
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM fru c
initial amount: NaN
name: D-Fructose
has only substance units: false
is: HMDB00660
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
constant: false
boundary condition: false
is: CHEBI:15824
initial concentration: 1.0
is: C00095

metaR r1650
modifier: MODEL1310110019#
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM o2 x
constant: false
is: C00007
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
is: HMDB01377
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: O2
is: SBO:0000247
type: Species

metaR r0267
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
modifier: MODEL1310110019#
type: Reaction
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:

metaR r1796
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR GCC2am
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoamide), mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110019#

metaR ILETAm
reactant: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: isoleucine transaminase, mitochondrial

metaR GLYCTO1p
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Glycolate oxidase, peroxisome
reversible: false
product: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15

metaR UDPGLCAter
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reactant: MODEL1310110019#
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true

metaM aacoa m
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
boundary condition: false
type: Species
is: CHEBI:57286
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01484
is: SBO:0000247

metaM acetone m
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15347
is: HMDB01659
constant: false
boundary condition: false
has only substance units: false
name: acetone
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

W3 CDTF: Fri Aug 31 06:19:07 BST 2012

metaM ditp n
has only substance units: false
is: CHEBI:61382
initial amount: NaN
name: dITP(4-)
constant: false
type: Species
is: SBO:0000247
is: HMDB03537
boundary condition: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial concentration: 1.0

metaR r1651
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_5772aaba_4094_4dae_a71b_f778b939f776
boundary condition: true
initial amount: NaN
is: P00491
has only substance units: false
is: SBO:0000252
name: PNP
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4860

metaR r0339
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.2.22
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110019#_e7e1f278_1276_4ff4_9565_c6f0fbd8b349
is encoded by: hsa:50
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACO2
type: Species
constant: false
is: Q99798

http://identifiers.org/biomodels.db/MODEL1310110019#_c4bdbe6a_406d_4a9e_bedc_76414fbe9a0b
boundary condition: true
has only substance units: false
name: NDUFA2
initial amount: NaN
is: SBO:0000252
type: Species
is: O43678
is encoded by: hsa:4695
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_6fa4bc2d_237f_406b_a81c_ce6707e2a7be
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51557
type: Species
is: Q5TDP6
name: LGSN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_9faf553d_2ff0_4078_a3ff_a90d8c7ceafa
initial amount: NaN
has only substance units: false
name: XDH
is: SBO:0000252
type: Species
is: P47989
boundary condition: true
constant: false
is encoded by: hsa:7498
initial concentration: NaN

metaM HC02210 e
initial concentration: 1.0
name: prostaglandin-d3
constant: false
is: SBO:0000247
type: Species
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
has only substance units: false
boundary condition: false

metaM HC00460 c
has only substance units: false
is: CHEBI:58044
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2,5-dihydroxybenzoate
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
type: Species
constant: false

metaR GLNASNNaEx
modifier: MODEL1310110019#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110019#
is described by: ECO:0000269
fast: false
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR FUMSO3tm
reversible: true
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110019#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110019#
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110019#

metaR r2328
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
is: CHEBI:57795
constant: false

metaR DNDPt21m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: dTDP transport via ADP antiport
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_0b6492fc_b32c_4f26_a7ef_43891504aa28
type: Species
is: Q96PL7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9154
has only substance units: false
name: SLC28A1
initial amount: NaN
constant: false

metaR DASCBR
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.8.4.1
fast: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000176
reversible: false
modifier: MODEL1310110019#
type: Reaction
name: dehydroascorbate reductase
is described by: ECO:0000269
reactant: MODEL1310110019#

metaM 10fthf7glu e
initial concentration: 1.0
boundary condition: false
is: HMDB00108
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial amount: NaN
is: CHEBI:16236

metaM pi x
constant: false
has only substance units: false
is: HMDB00973
boundary condition: false
initial concentration: 1.0
name: hydrogenphosphate
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial amount: NaN
is: SBO:0000247

metaR r2433
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
type: Reaction

metaR FAOXC101C8m
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM i c
is: SBO:0000247
name: iodide
is: HMDB12238
is: CHEBI:16382
initial amount: NaN
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM sph1p c
initial amount: NaN
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
boundary condition: false
is: HMDB01383
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
has only substance units: false
type: Species

metaR METyLATthc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR ALOX5
reversible: false
reactant: MODEL1310110019#
name: Arachidonate 5-lipoxygenase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.34

http://identifiers.org/biomodels.db/MODEL1310110019#_e57871c1_dfc6_41ae_87ce_85ec0527a8b1
boundary condition: true
is encoded by: hsa:1716
type: Species
initial concentration: NaN
name: DGUOK
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR DCK2n
reversible: true
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
name: Deoxycytidine kinase, nuclear (UTP)

metaM tyr L c
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00158
type: Species
initial concentration: 1.0

metaR AMETr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-methionine intracellular diffusion
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
type: Reaction

metaR r2327
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110019#

metaR PI34P5K
is: SBO:0000176
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.68
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: false
type: Reaction

metaM arachd x
is: HMDB01043
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
is: CHEBI:32395
initial amount: NaN
name: arachidonate
initial concentration: 1.0
type: Species

metaR KCCt
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110019#
name: K+-Cl- cotransport
fast: false
kinetic law: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_487b5027_9fc6_4d28_8035_32ed6591c842
initial concentration: NaN
is: Q9BYZ2
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: LDHAL6B
has only substance units: false
initial amount: NaN
is encoded by: hsa:92483

http://identifiers.org/biomodels.db/MODEL1310110019#_2c0ce8a8_ea1d_4aab_9157_2b8dd6e25060
type: Species
is: O75438
is: SBO:0000252
name: NDUFB1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4707
has only substance units: false

metaM cholate e
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00619
name: Cholate
type: Species
is: CHEBI:29747

metaM co c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17245
name: carbon monoxide
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361

metaM HC00250 c
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: hydrosulfide
is: CHEBI:29919

http://identifiers.org/biomodels.db/MODEL1310110019#_fbe61578_741c_49be_83be_2efee0964578
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:763
name: CA5A
boundary condition: true
has only substance units: false
is: P35218
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_3ee42baa_524d_451f_861b_09fc8734c59b
has only substance units: false
name: _AI684467_1_m
initial amount: NaN
is encoded by: hsa:AI684467
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d24fda37_f5f9_4456_b73b_998fd45988b1
constant: false
boundary condition: true
name: ACAT2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9BWD1
is: SBO:0000252
type: Species
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110019#_c0cdd002_8968_48aa_958b_1a9af98a3fe0
type: Species
is: SBO:0000252
name: SLC13A1
initial concentration: NaN
constant: false
boundary condition: true
is: Q9BZW2
initial amount: NaN
is encoded by: hsa:6561
has only substance units: false

metaM cholp c
initial amount: NaN
is: CHEBI:295975
type: Species
name: choline phosphate(1-)
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_43ca2920_35ec_4a79_b76c_7193fe34e450
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9UBM1
has only substance units: false
name: PEMT
boundary condition: true
is encoded by: hsa:10400
type: Species

metaM pcrn m
constant: false
name: propionyl-carnitine
boundary condition: false
is: HMDB00824
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR r1649
reactant: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
type: Reaction

metaR r0345
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
product: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_fdd4dcc9_7323_4952_a6f0_57de0e1831f4
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: Q9UBF8
is encoded by: hsa:5298
name: PI4KB
initial concentration: NaN

metaM creat c
is: HMDB00064
type: Species
is: CHEBI:16919
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
name: creatine
is: SBO:0000247
boundary condition: false
constant: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR SGPL12r
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
product: MODEL1310110019#
reversible: false
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
name: Sphingosine-1-phosphate lyase
is described by: ECO:0000304

metaR r2326
fast: false
reactant: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM HC00591 c
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16769
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6c1761f4_3d3f_4c07_aa3f_803db2ee622d
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P17174
is encoded by: hsa:2805
initial amount: NaN
type: Species
name: GOT1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_872be71a_396b_4eb6_aaf3_36a3a234b75d
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ADSL
is encoded by: hsa:158
has only substance units: false
is: SBO:0000252

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM i e
is: CHEBI:16382
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
initial concentration: 1.0
is: HMDB12238

metaR ADCim
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaM sph1p e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
constant: false
is: HMDB01383
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_7ebecb33_109c_4582_8bbc_82e7c6d21a02
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: CDIPT
type: Species
is: O14735
is encoded by: hsa:10423
is: SBO:0000252
boundary condition: true

metaR ARACHDt2
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaM tyr L e
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
is: SBO:0000247
name: L-tyrosine
initial amount: NaN
has only substance units: false
is: HMDB00158
boundary condition: false
type: Species
initial concentration: 1.0

metaR NMNATr
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110019#
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR CITtbm
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
type: Reaction
name: citrate transport, mitochondrial
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaM didp n
is: CHEBI:28823
is: SBO:0000247
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
constant: false
initial amount: NaN
name: dIDP
initial concentration: 1.0
type: Species
boundary condition: false

metaR r1648
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reversible: true

metaM HC01231 c
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
is: CHEBI:58480

http://identifiers.org/biomodels.db/MODEL1310110019#_458e207b_3b59_4be6_84bb_4ba6ed19e1dc
has only substance units: false
name: PPT1
is: SBO:0000252
type: Species
is: Q6FGQ4
is encoded by: hsa:5538
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR DNDPt41m
reactant: MODEL1310110019#
type: Reaction
fast: false
modifier: MODEL1310110019#
reversible: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUTP transport via dCDP antiport
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110019#

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaR DNDPt29m
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110019#
product: MODEL1310110019#
name: dCDP transport via dADP antiport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110019#

metaM prpp e
initial concentration: 1.0
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Species
has only substance units: false
is: HMDB00280
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR VD3
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
name: Vitamin D3 formation
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000134
reversible: true
is: SBO:0000176

metaR r1647
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f8ded632_35e5_4d87_b362_f76f5c738fcd
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5498
boundary condition: true
has only substance units: false
initial amount: NaN
is: P50336
name: PPOX
constant: false

metaR r1589
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaR THRGLNexR
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
product: MODEL1310110019#
modifier: MODEL1310110019#
name: L-threonine/glycine reversible exchange
type: Reaction
reversible: true
reactant: MODEL1310110019#

metaR RE1448N
name: RE1448
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000176

metaM ribflv c
initial concentration: 1.0
name: Riboflavin
initial amount: NaN
is: C00255
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110019#_c54b7cae_4f33_4432_b12f_4d72aa26ebbb
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8527
has only substance units: false
type: Species
boundary condition: true
constant: false
name: DGKD

http://identifiers.org/biomodels.db/MODEL1310110019#_08e65233_c336_4f8b_ad22_006aed757bec
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AA177072
type: Species
name: _AA177072_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM prostge1 e
is: HMDB01442
constant: false
type: Species
name: prostaglandin E1(1-)
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r0639
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110019#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR ACETONEt2m
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: acetone mitochondrial transport via proton symport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true

metaR r1163
is: SBO:0000185
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
fast: false

metaR r1377
product: MODEL1310110019#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387
type: Species
is: HMDB11123
boundary condition: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial amount: NaN

metaM dhf c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
boundary condition: false
type: Species
is: CHEBI:57451
constant: false
is: C00415
has only substance units: false
is: HMDB01056
initial amount: NaN

metaR ACACt2m
reactant: MODEL1310110019#
type: Reaction
name: Acetoacetate mitochondrial transport via H+ symport
reversible: true
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
product: MODEL1310110019#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_fdffd165_ec6b_4c3d_8f20_10a718edf781
has part: Q53YB7
has part: Q96KJ9
is encoded by: hsa:341947
initial concentration: NaN
is encoded by: hsa:1346
is encoded by: hsa:1340
is encoded by: hsa:84701
is encoded by: hsa:125965
is encoded by: hsa:1337
has part: P24311
has part: Q7Z4L0
has part: Q02221
is encoded by: hsa:1347
has part: P13073
is encoded by: hsa:1350
has part: Q53XN1
is encoded by: hsa:1327
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1329
has part: P09669
has part: P15954
boundary condition: true
is encoded by: hsa:1345
has part: P14854
has part: P20674
constant: false
type: Species
is encoded by: hsa:4514
has part: P00414
initial amount: NaN
is encoded by: hsa:1349
is encoded by: hsa:170712
is encoded by: hsa:9167
is encoded by: hsa:1339
has part: Q8TF08
is encoded by: hsa:9377
has part: Q6FGA0
has part: P24310
is encoded by: hsa:1351
has only substance units: false
has part: Q7GXY8
has part: H0UI06
is encoded by: hsa:4513
has part: P12074
has part: Q6YFQ2
is encoded by: hsa:4512
has part: Q7GXZ8
is: SBO:0000297

metaR r1646
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaR r0400
fast: false
reversible: true
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is: SBO:0000176
type: Reaction
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110019#

metaR PItn
name: phosphate transport, nuclear
type: Reaction
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000

metaM 10fthf c
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
type: Species
initial amount: NaN
is: C00234
is: CHEBI:57454
is: HMDB00972
has only substance units: false

metaM pi r
type: Species
is: C00009
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:43474
boundary condition: false
constant: false
has only substance units: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973

metaR r0497
product: MODEL1310110019#
is: SBO:0000176
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110019#
fast: false

metaR r0638
fast: false
type: Reaction
kinetic law: MODEL1310110019#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110019#
modifier: MODEL1310110019#

metaM leuktrB4 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
initial amount: NaN
constant: false
type: Species
name: leukotriene B4(1-)
is: CHEBI:57461
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_1c7f23ab_dcd9_4b22_929a_18aa19060a36
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC23A1
is encoded by: hsa:9963
is: Q9UHI7

metaR RE2799C
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110019#
name: RE2799
reactant: MODEL1310110019#
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:

metaR r1378
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction

metaR DIDPtn
reactant: MODEL1310110019#
is described by: ECO:0000000
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c16a94a3_018d_44d9_80fe_cc9de0541ce5
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI769281_1_e
constant: false
is encoded by: hsa:AI769281
type: Species
boundary condition: true

metaM prpp c
boundary condition: false
is: SBO:0000247
type: Species
is: C00119
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
has only substance units: false
is: HMDB00280
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial amount: NaN

metaR ALASERNaEx
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: false
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
fast: false

metaM dhlam m
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00985
is: SBO:0000247
name: dihydrolipoamide
is: CHEBI:17694
constant: false
boundary condition: false

metaR ALAt4
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
product: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
name: Alanine-Sodium symporter
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR r1645
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
type: Reaction

metaR SPMTDe
kinetic law: MODEL1310110019#
is described by: ECO:0000134
reactant: MODEL1310110019#
name: SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_78843ef8_01b5_46a7_972e_494e39f5e37d
is: Q6IBB5
is encoded by: hsa:4694
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFA1
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0494
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
reversible: true

metaR ORPT
name: orotate phosphoribosyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true

metaM ribflv e
is: C00255
initial concentration: 1.0
constant: false
name: Riboflavin
is: SBO:0000247
is: CHEBI:3554
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244
initial amount: NaN

metaM so3 m
is: SBO:0000247
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
name: hydrogensulfite
initial amount: NaN
boundary condition: false
is: HMDB00240
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_aeae5270_d576_4530_9be0_79ab6f0cf19a
is encoded by: hsa:5464
is: SBO:0000252
name: PPA1
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q15181
has only substance units: false
constant: false

metaM spmd e
is: CHEBI:57834
type: Species
is: SBO:0000247
constant: false
is: C00315
boundary condition: false
initial concentration: 1.0
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial amount: NaN
name: Spermidine

http://identifiers.org/biomodels.db/MODEL1310110019#_03c1637a_e00f_4660_b133_1dd16c2f5f65
has only substance units: false
initial amount: NaN
name: ALDH3B2
constant: false
is: SBO:0000252
is: P48448
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:222

metaR ALAt2r
product: MODEL1310110019#
reactant: MODEL1310110019#
name: L-alanine reversible transport via proton symport
is: SBO:0000185
fast: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR FUMSO4tm
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1d9f400c_e5d2_4ad5_b771_2bd7b22ce419
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: Q9Y5P4
is encoded by: hsa:10087
initial amount: NaN
name: COL4A3BP
constant: false

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR C160CPT2
fast: false
product: MODEL1310110019#
name: C160 transport into the mitochondria
reversible: false
reactant: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM dhf e
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57451
is: HMDB01056
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_1ce15cd4_5824_450f_b92c_ea49bd7f2223
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:65010
is: Q9Y3Y1
name: SLC26A6
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR NTD2m
name: 5'-nucleotidase (UMP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
fast: false
product: MODEL1310110019#

metaR r1644
modifier: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110019#
fast: false

metaR r1588
is: SBO:0000185
reversible: true
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_23a82f87_e474_4b7c_b452_13e6cbef15bb
boundary condition: true
is: O75908
initial concentration: NaN
constant: false
is encoded by: hsa:8435
has only substance units: false
type: Species
name: SOAT2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_1d299fac_c564_4399_943c_bb814da5eb01
has only substance units: false
is encoded by: hsa:1606
is: P23743
is: SBO:0000252
initial concentration: NaN
name: DGKA
constant: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_5a68e164_7d14_47e7_9627_8a2716556d9c
boundary condition: true
is: Q9Y2Q0
initial amount: NaN
type: Species
is encoded by: hsa:10396
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: ATP8A1

metaR 2AMADPTm
product: MODEL1310110019#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
modifier: MODEL1310110019#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269

metaR 3HBCOAHLm
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110019#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reactant: MODEL1310110019#
type: Reaction

metaM HC00250 e
initial amount: NaN
boundary condition: false
name: hydrosulfide
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaM cholate c
name: Cholate
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB00619
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
is: SBO:0000247
initial concentration: 1.0

metaR r0280
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#

metaM leuktrB4 c
has only substance units: false
type: Species
constant: false
is: CHEBI:57461
is: HMDB01085
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
name: leukotriene B4(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_faafd3c9_ab48_43ba_8e1a_ec89083e0906
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6530
name: SLC6A2
is: Q96KH8
initial amount: NaN
initial concentration: NaN

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r2329
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_51a98152_2d58_4d6a_88c7_ffd19a2341a9
initial amount: NaN
has only substance units: false
is encoded by: hsa:5160
boundary condition: true
is: SBO:0000252
name: PDHA1
type: Species
constant: false
initial concentration: NaN
is: P08559

http://identifiers.org/biomodels.db/MODEL1310110019#_9861fa20_5d1d_409c_9257_d2c2f2c86426
boundary condition: true
name: SLC5A2
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6524
is: SBO:0000252
is: P31639
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c351410f_d7d8_48c9_90bf_abea48827498
name: PRDX3
constant: false
is: SBO:0000252
is: E9PH29
is encoded by: hsa:10935
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR r2534
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
fast: false
reversible: true

metaM pheacgln e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB06344
constant: false
is: CHEBI:58310
type: Species
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate

http://identifiers.org/biomodels.db/MODEL1310110019#_a6d47010_0ae3_4051_a1ed_c25227841224
name: PSAT1
initial concentration: NaN
is: Q9Y617
type: Species
is encoded by: hsa:29968
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaM HC00591 m
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
name: 2-oxoglutaramate
is: SBO:0000247
boundary condition: false
is: CHEBI:16769
constant: false
initial amount: NaN
type: Species

metaR r2320
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaR r1585
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_59c788f0_4b08_4779_8dc1_9b5cbc82bce6
is: Q9NS18
constant: false
is encoded by: hsa:51022
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: GLRX2

http://identifiers.org/biomodels.db/MODEL1310110019#_75477319_f379_421a_bf52_50dc7ffa3b37
boundary condition: true
type: Species
initial amount: NaN
name: BDH1
initial concentration: NaN
is encoded by: hsa:622
is: Q02338
constant: false
is: SBO:0000252
has only substance units: false

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is described by: ECO:0000269
product: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.4.1.4
reactant: MODEL1310110019#

metaR r2384
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: false
modifier: MODEL1310110019#
type: Reaction
fast: false
reactant: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1586
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR GLYCtm
reactant: MODEL1310110019#
type: Reaction
name: glycerol transport
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false

metaR r0634
modifier: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR r0340
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_e12d8e72_9e10_470d_9851_4241b75d2092
initial concentration: NaN
is: Q6FGV9
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10654
has only substance units: false
name: PMVK
boundary condition: true
constant: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR 5ADTSTSTERONESte
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
name: sulfonated testosterone transport
fast: false

metaR r0560
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_fc7a8a4c_b934_4b05_b21a_357ba98f65f0
constant: false
is: P04075
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:226
name: ALDOA
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_7a7d66a4_1cb8_490c_89a9_f1165132acbb
is: SBO:0000252
is encoded by: hsa:4846
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: A0S0A7
name: NOS3
boundary condition: true
constant: false

metaR r2439
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

http://identifiers.org/biomodels.db/MODEL1310110019#_875b3b8e_ef22_4cf8_b4f9_1d3a292e34fc
is: P54868
is encoded by: hsa:3158
name: HMGCS2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r2532
product: MODEL1310110019#
reversible: true
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185

metaR NDPK1
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110019#
is described by: ECO:0000134
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP)
product: MODEL1310110019#

metaR FUMTSULtm
type: Reaction
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_1ff79122_4021_4c84_88d0_6e72aebecf43
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: LIPA
initial concentration: NaN
is: P38571
constant: false
has only substance units: false
is encoded by: hsa:3988
type: Species

metaM prostge1 c
type: Species
is: HMDB01442
is: CHEBI:57397
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: prostaglandin E1(1-)

http://identifiers.org/biomodels.db/MODEL1310110019#_c79105d0_b1b2_49ad_b9a2_7ecc75ae0dd8
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
name: ACP1
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: Q59EH3

http://identifiers.org/biomodels.db/MODEL1310110019#_57d8b6a7_da56_4ab5_96bf_52021fbd2ce4
is encoded by: hsa:AA526438
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: _AA526438_1_m
boundary condition: true

metaR PCRNtc
name: transport into the cytosol from peroxisome (carnitine)
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
is described by: ECO:0000000
reversible: false

metaR r2380
reactant: MODEL1310110019#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110019#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reactant: MODEL1310110019#
fast: false
type: Reaction
modifier: MODEL1310110019#
is described by: ECO:0000000
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false

metaR r1583
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110019#

metaR r0633
reversible: true
modifier: MODEL1310110019#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR ITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
name: ITP nuclear transport

metaR RE2974N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: RE2974
reversible: true
reactant: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_f77355f4_95e2_4746_8165_073fecda5349
boundary condition: true
is: SBO:0000252
type: Species
name: PLA2G2E
constant: false
is encoded by: hsa:30814
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9NZK7

metaM arachd r
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32395
has only substance units: false
is: HMDB01043
name: arachidonate

metaM crm hs r
type: Species
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
name: N-acylsphingosine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2382
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110019#

metaR r1584
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000

metaR r0788
is described by: ECO:0000000
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110019#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
fast: false
modifier: MODEL1310110019#
reversible: true
type: Reaction

metaR CRMPte
reversible: true
name: crmp hs transport
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
product: MODEL1310110019#

metaM prpncoa m
is: CHEBI:57367
is: SBO:0000247
constant: false
has only substance units: false
name: acryloyl-CoA(4-)
is: HMDB02307
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 10fthf m
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
initial amount: NaN
is: HMDB00972
is: CHEBI:57454
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0f5e6ee3_608f_4814_aa17_88661d61dceb
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6120
is: SBO:0000252
type: Species
has only substance units: false
name: RPE
is: Q96AT9
initial concentration: NaN

metaR r2387
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#

metaM crmp hs e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57674
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
name: ceramide 1-phosphate(2-)
type: Species
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_07ac77c5_96f4_4622_b3b1_08ab2a883b99
initial concentration: NaN
boundary condition: true
name: _AU149534_1_e
is encoded by: hsa:AU149534
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaM hista c
is: HMDB00870
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58432
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
boundary condition: false

metaM orot e
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
name: orotate
is: HMDB00226
constant: false
type: Species
is: CHEBI:30839
has only substance units: false

metaR r2110
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110019#

metaM creat e
is: HMDB00064
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
name: creatine
constant: false
initial concentration: 1.0
is: CHEBI:16919
type: Species
is: SBO:0000247

metaR r2324
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110019#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR GLNtN1
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_ab7630c9_3f62_499e_b62b_ce27afcd217f
is encoded by: hsa:56954
name: NIT2
type: Species
constant: false
is: Q9NQR4
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR ECOAH9m
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
fast: false
product: MODEL1310110019#

metaM grdp x
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01285
is: CHEBI:58057
name: geranyl diphosphate(3-)
has only substance units: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341

http://identifiers.org/biomodels.db/MODEL1310110019#_ed9fa484_4470_48d2_aa1d_cf6f6ef44eb5
initial amount: NaN
is: SBO:0000252
is: O95299
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFA10
is encoded by: hsa:4705
constant: false

metaR r0789
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
reactant: MODEL1310110019#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_2371a3d3_bd60_4bed_8684_e0fc5db5b5a2
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:284111
name: SLC13A5
initial amount: NaN
is: Q86YT5
constant: false
initial concentration: NaN

metaR r0974
is described by: ECO:0000000
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185

metaM 3mop m
boundary condition: false
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
type: Species
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
initial concentration: 1.0
is: HMDB00491
constant: false
is: SBO:0000247

metaR r1581
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110019#

metaR r2388
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000

metaR ETHAK
name: Ethanolamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.82
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000269
is: SBO:0000176

metaR PHEMEtm
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
is: SBO:0000185
product: MODEL1310110019#
reversible: true
type: Reaction
name: Heme transport to cytosol
reactant: MODEL1310110019#
fast: false

metaR r2323
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0408
is: SBO:0000176
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR UGCG
kinetic law: MODEL1310110019#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80
name: Ceramide glucosyltransferase
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reactant: MODEL1310110019#

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR r0630
kinetic law: MODEL1310110019#
fast: false
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110019#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110019#

metaR NADtpu
is described by: ECO:0000000
name: NAD transporter, peroxisome
reversible: false
type: Reaction
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR r0973
kinetic law: MODEL1310110019#
type: Reaction
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a1a346a2_beaa_463c_a51b_56fef659cb78
has only substance units: false
name: LHPP
boundary condition: true
is encoded by: hsa:64077
constant: false
is: Q9H008
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaM hista e
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58432
has only substance units: false
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
boundary condition: false
is: SBO:0000247

metaR r2322
is described by: ECO:0000000
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110019#
is: SBO:0000185

metaR MECOALm
is: SBO:0000176
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaM orot c
boundary condition: false
initial concentration: 1.0
is: C00295
name: Orotate
is: SBO:0000247
initial amount: NaN
is: HMDB00226
has only substance units: false
type: Species
constant: false
is: CHEBI:30839
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaM dhf m
is: HMDB01056
is: SBO:0000247
name: dihydrofolate(2-)
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57451

metaR PItx
is: SBO:0000185
name: Phosphate transporter, peroxisome
type: Reaction
reactant: MODEL1310110019#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM mi34p c
is: CHEBI:28858
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: 1D-myo-Inositol 3,4-bisphosphate
initial amount: NaN
is: HMDB06235
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063

metaM crmp hs c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
is: CHEBI:57674
name: ceramide 1-phosphate(2-)
initial concentration: 1.0

metaR r2385
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: false
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_da74103c_3008_4b30_8e23_79195022e4d2
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: ALDH9A1
is: SBO:0000252
is: P49189
is encoded by: hsa:223

metaR FMNAT
fast: false
type: Reaction
is described by: ECO:0000134
name: FMN adenylyltransferase
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.7.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaR r2435
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

metaR r0407
kinetic law: MODEL1310110019#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
modifier: MODEL1310110019#
product: MODEL1310110019#

metaR BUTt2r
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
name: Butyrate transport via proton symport, reversible
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
type: Reaction

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110019#
name: orotidine-5'-phosphate decarboxylase
product: MODEL1310110019#
reversible: false
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10

http://identifiers.org/biomodels.db/MODEL1310110019#_296438ac_b612_4620_ae41_dd17678db254
boundary condition: true
is encoded by: hsa:3028
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: HSD17B10
initial amount: NaN
type: Species
constant: false
is: Q99714

http://identifiers.org/biomodels.db/MODEL1310110019#_6088389a_baf3_429a_9acd_5d9fa70c00d3
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: SLC28A3
has only substance units: false
is: Q9HAS3
is encoded by: hsa:64078
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_6cf71aee_233a_47ca_b7b8_26ed947825aa
is encoded by: hsa:4541
is: Q7GXZ1
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: ND6
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_486ff4cc_acbf_4aea_83a6_e27ea3476beb
boundary condition: true
type: Species
name: RRM2B
is: Q7LG56
is encoded by: hsa:50484
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR 4MOPt2im
reactant: MODEL1310110019#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#

metaM HC02210 c
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: prostaglandin-d3
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939

metaR GSNt
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
product: MODEL1310110019#
name: guanosine facilated transport in cytosol
reversible: true
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1251729f_a2d1_4b56_bdb5_7412a7a4417c
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:400410
constant: false
name: ST20
has only substance units: false
is: Q9HBF5
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_2275b122_c8c5_4213_b873_e297e634c86e
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: SLC43A1
boundary condition: true
is encoded by: hsa:8501
is: O75387

metaR r2321
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110019#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#

metaM co e
is: HMDB01361
is: CHEBI:17245
boundary condition: false
is: SBO:0000247
name: carbon monoxide
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaR r2386
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
modifier: MODEL1310110019#
reversible: false

metaM pcrn x
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: propionyl-carnitine
initial concentration: 1.0
boundary condition: false
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738

metaR r2535
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_64ef21b9_0bab_495f_8939_5565182dbd7d
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9NQR4
is encoded by: hsa:56954
boundary condition: true
initial amount: NaN
has only substance units: false
name: NIT2

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_e91bd6f7_77d6_450d_91cc_412f0fd1f0fe
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2180
is: P33121
name: ACSL1
is: SBO:0000252
has only substance units: false
initial concentration: NaN

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR r1580
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: true
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b2787cff_128d_41e1_9acc_e7e55214d9c8
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: DUOX1
constant: false
is encoded by: hsa:53905
type: Species

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110019#_ec7da723_8481_45ae_bee2_a0ddf48e519e
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: ENPP1
is: SBO:0000252
is: P22413
is encoded by: hsa:5167
initial concentration: NaN

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3b0331bd_a941_4375_8567_df8c49c034cf
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: GGT1
is: P19440
initial concentration: NaN
constant: false
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110019#_707e3a8d_44ba_47ce_a08f_105ac1cb428e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10007
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: P46926
has only substance units: false
name: GNPDA1

http://identifiers.org/biomodels.db/MODEL1310110019#_dedc80fd_4253_4628_873f_3e952d2c10ab
is: SBO:0000252
is: Q92903
name: CDS1
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1040
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ff028ece_6574_4d68_b84a_b91292db025f
initial concentration: NaN
name: PLCZ1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:89869
has only substance units: false
type: Species
boundary condition: true
is: Q86YW0

metaR CYTK13n
fast: false
is: SBO:0000176
name: cytidylate kinase (dCMP,dATP),nuclear
is described by: ECO:0000269
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_9fadccca_353a_4597_a440_1c627f1ba1b3
constant: false
has only substance units: false
is encoded by: hsa:160851
type: Species
initial amount: NaN
initial concentration: NaN
name: DGKH
is: SBO:0000252
is: A8K0I1
boundary condition: true

metaR THRGLNNaEx
is described by: ECO:0000269
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
reversible: false
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is: SBO:0000185

metaM bilirub r
is: CHEBI:57977
constant: false
boundary condition: false
name: bilirubin(2-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110019#_6a6dd970_602e_4c33_8f88_a5bddcfc3cf2
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q8IZV5
initial concentration: NaN
is encoded by: hsa:157506
has only substance units: false
name: RDH10
type: Species
constant: false

metaM ala L c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
has only substance units: false
boundary condition: false
type: Species
name: L-alanine
is: HMDB00161

metaR r1400
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
name: Active transport
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110019#

metaR r2053
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110019#

metaR r2101
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
fast: false
is: SBO:0000185
reversible: true

metaR NDPK6
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_0cf26c2c_a81f_46a4_9405_44c063f693dd
initial amount: NaN
is: SBO:0000252
is: Q86V21
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:65985
type: Species
name: AACS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_cc4d2c9f_957d_4cdb_9314_1584499086ef
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: _AU149534_1_m
is encoded by: hsa:AU149534

metaR r0853
product: MODEL1310110019#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reactant: MODEL1310110019#
name: Facilitated diffusion
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM udpgal e
boundary condition: false
is: HMDB00302
is: SBO:0000247
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: UDP-D-galactose(2-)
constant: false

metaM lnlccoa r
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM pi g
constant: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial concentration: 1.0
type: Species
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_df12e63e_d2a1_45f8_a0d4_47ad326c4cf4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:278
is: P04745
initial amount: NaN
initial concentration: NaN
name: AMY1C
constant: false
type: Species
has only substance units: false

metaR PHEt4
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reversible: false
modifier: MODEL1310110019#
name: L-phenylalanine transport in via sodium symport
is described by: ECO:0000269
product: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_dc629505_4e53_40a2_adc4_ea725038f933
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O00337
is: SBO:0000252
name: SLC28A1
is encoded by: hsa:9154
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ac8a9d47_6897_4098_a532_931fb3e03d80
initial amount: NaN
is encoded by: hsa:8398
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: O60733
type: Species
boundary condition: true
name: PLA2G6

http://identifiers.org/biomodels.db/MODEL1310110019#_744fad5d_2ee6_4d77_afcd_2d984a8ccd27
constant: false
type: Species
name: GAPDH
is: SBO:0000252
is encoded by: hsa:2597
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: E7EUT4
boundary condition: true

metaR r0022
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110019#

metaR r2379
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR PCRNtm
type: Reaction
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000000
name: transport into the mitochondria from cytosol (carnitine)
product: MODEL1310110019#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_2129ddf1_e4f0_49b4_a52b_4f0053644316
is encoded by: hsa:AI024818
constant: false
initial amount: NaN
name: _AI024818_1_c
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR NDPK7
is described by: ECO:0000269
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r2102
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000

metaM 34hpp e
type: Species
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
has only substance units: false
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_9e94a573_da84_4a61_a547_e3b4e8c15f51
has only substance units: false
has part: P21912
initial concentration: NaN
constant: false
is: SBO:0000297
has part: P31040
type: Species
is encoded by: hsa:6390
initial amount: NaN
boundary condition: true
is encoded by: hsa:6392
has part: Q99643
has part: O14521
is encoded by: hsa:6391
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110019#_0a22a651_7bdf_4e4c_a83f_9dcc7ea4f5ce
constant: false
name: INPP5A
has only substance units: false
type: Species
is: Q14642
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3632
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_5a9970af_59ec_46a1_83cd_7594c41e8f89
type: Species
is encoded by: hsa:3284
has only substance units: false
is: SBO:0000252
name: HSD3B2
is: P26439
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM HC01610 e
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:28607
is: SBO:0000247
initial amount: NaN
name: CoproporphyrinogenI
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_5ab9f1ef_76b1_4d5c_96ee_8e0b8578bf1c
name: SHMT1
has only substance units: false
initial amount: NaN
is encoded by: hsa:6470
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR CYTK13
modifier: MODEL1310110019#
reversible: true
name: cytidylate kinase (dCMP,dATP)
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_bb3bba61_f8ec_4f3e_81d3_490a20df0a50
constant: false
has only substance units: false
initial amount: NaN
is: A8K0T6
is encoded by: hsa:55512
initial concentration: NaN
is: SBO:0000252
name: SMPD3
type: Species
boundary condition: true

metaR r0780
kinetic law: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
reactant: MODEL1310110019#

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

metaR CLHCO3tex2
name: chloride transport via bicarbonate countertransport (2:1)
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_8654245e_c691_4b5c_a9db_91d32b593356
initial amount: NaN
constant: false
is encoded by: hsa:5211
type: Species
has only substance units: false
boundary condition: true
is: P17858
name: PFKL
is: SBO:0000252
initial concentration: NaN

metaR DOLPMT4 Ler
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#

metaM ps hs e
type: Species
has only substance units: false
is: SBO:0000247
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18303
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6ac4eccf_db58_4b1a_8aa7_6dabca4e3d0d
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: O43674
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4711
name: NDUFB5

http://identifiers.org/biomodels.db/MODEL1310110019#_d6a72367_a9de_41b7_9898_5db04cfceb12
name: SLCO2A1
is: Q92959
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6578
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_f473981f_0c42_4709_95cf_0876fe225bd9
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:218
initial concentration: NaN
constant: false
is: P30838
boundary condition: true
type: Species
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110019#_994c9d73_935a_40a7_ba5d_fe6b0a7714af
has only substance units: false
name: GNPDA2
initial amount: NaN
type: Species
is: Q8TDQ7
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:132789
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_fbf38527_8afd_4fa2_83e3_5e3e2bd217d2
initial concentration: NaN
is encoded by: hsa:84890
boundary condition: true
is: SBO:0000252
name: ADO
type: Species
has only substance units: false
constant: false
is: B3KXN9
initial amount: NaN

metaR NDPK8
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110019#
name: Nucleoside-diphosphate kinase (ATP:dADP)
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
fast: false
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_103c2eab_0752_4247_80a5_3268d4926e19
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: DGUOK
has only substance units: false
is: Q16854
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110019#_c664da0d_ae18_4fb4_bb20_2c01a08f0135
initial amount: NaN
name: HEPH
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:9843
initial concentration: NaN
type: Species
has only substance units: false
is: E9PHN8

metaR r2378
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR CYTK14
is: SBO:0000176
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
name: cytidylate kinase (dCMP,UTP)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM udpgal c
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
is: CHEBI:58439
is: HMDB00302
is: SBO:0000247
initial concentration: 1.0
type: Species
name: UDP-D-galactose(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_70e23d41_029a_466e_b94c_e6336fb0c4da
name: AKR1A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: P14550
constant: false
is encoded by: hsa:10327
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b6ba52d3_e84e_4791_9eb6_3fb1c2b813fa
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8659
type: Species
constant: false
initial amount: NaN
name: ALDH4A1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_9355a0d1_3dd6_416d_a75b_1a695933b70f
has only substance units: false
is: Q542Y6
name: PLA2G12A
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:81579
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: NO transport (diffusion)
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaR FORtr
name: FOR transporter, endoplasmic reticulum
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_c3c36452_8f3b_4150_9b82_f53983e09048
initial amount: NaN
constant: false
has only substance units: false
name: HAO2
is encoded by: hsa:51179
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_1f9fe6be_85c1_43e3_9d59_5d518e40a54d
is encoded by: hsa:AV713053
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _AV713053_1_m
constant: false
boundary condition: true
is: SBO:0000252

metaR ADNt
product: MODEL1310110019#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: adenosine facilated transport in cytosol
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110019#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_5a69b818_ce15_435e_8af0_a47d072a821b
is encoded by: hsa:AV727634
name: _AV727634_1_c
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR r1492
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
name: Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
product: MODEL1310110019#
type: Reaction

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r2100
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NDPK9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP)
type: Reaction
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM 13 cis retn c
is: D00348
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06219
has only substance units: false
constant: false
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
is: http://identifiers.org/pubchem.compound/7847414

metaR NDPK6n
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110019#_93fc9047_f29f_47eb_9ba6_a10f9507a165
is encoded by: hsa:3099
is: P52789
initial amount: NaN
initial concentration: NaN
name: HK2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaR r2377
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_0667945e_2813_4ca2_b0c3_d77446679a0b
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:501
is: E7EPT3
is: SBO:0000252
name: ALDH7A1

http://identifiers.org/biomodels.db/MODEL1310110019#_61a1b2ec_ec62_4537_9182_d1322215bddc
is: SBO:0000252
name: BLVRB
has only substance units: false
initial amount: NaN
constant: false
is: P30043
type: Species
is encoded by: hsa:645
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_4ed9881f_3297_4bcc_b1f3_5f5ff3819823
initial concentration: NaN
boundary condition: true
name: HSD17B10
is encoded by: hsa:3028
is: SBO:0000252
type: Species
is: Q99714
has only substance units: false
initial amount: NaN
constant: false

metaR TPI
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
product: MODEL1310110019#

metaM HC01231 m
is: CHEBI:58480
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaM 4hglusa m
is: CHEBI:27809
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
constant: false
name: L-4-hydroxyglutamic semialdehyde
boundary condition: false
type: Species
has only substance units: false

metaR UMPK3n
product: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR FBA
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
product: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
reversible: true
name: fructose-bisphosphate aldolase
modifier: MODEL1310110019#
is described by: ECO:0000134
kinetic law: MODEL1310110019#

metaR ECOAH12m
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110019#
fast: false
reversible: true
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110019#

metaR r2105
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0b54b7c3_01e7_4fd7_bf60_7a3e2ae55111
name: PPA2
is: Q9H2U2
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110019#_ff08a007_ff11_4caf_8f32_e60e4ce73141
boundary condition: true
is encoded by: hsa:3098
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q59FD4
type: Species
initial concentration: NaN
name: HK1
constant: false

metaR NDPK2
is: SBO:0000176
reactant: MODEL1310110019#
name: nucleoside-diphosphate kinase (ATP:UDP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000269
type: Reaction

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM 3mop e
constant: false
initial concentration: 1.0
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
is: CHEBI:28654
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_7d7420c0_7841_4a9f_b2b4_1c3bc08487b6
name: PLA2G2D
constant: false
is encoded by: hsa:26279
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9UNK4

metaM maltttr e
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
boundary condition: false
name: Maltotetraose
type: Species
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
constant: false
is: HMDB01296
initial amount: NaN
is: C02052
has only substance units: false
is: SBO:0000247

metaR r0781
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is described by: ECO:0000000
reversible: true
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0853bc1e_6823_4cd0_b225_078da6b5a78d
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:112724
initial concentration: NaN
name: RDH13
is: B3KVA3
is: SBO:0000252
constant: false

metaM HC02205 c
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
name: prostaglandin-b2
is: CHEBI:28099
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaM CE4794 m
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57923
type: Species
has only substance units: false
boundary condition: false
name: cis-6-dodecenoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_75fd7bec_74f9_4ff8_8771_b3f6c08ffc6f
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6390
is: SBO:0000252
is: P21912
constant: false
boundary condition: true
name: SDHB
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e86afadc_44ac_45a7_b7f8_6211fb82cd6e
is: P49753
name: ACOT2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10965
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_d2a54ee4_9a70_456b_8922_75b7e31ae374
name: PANK1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:53354

metaR DMNONCRNt
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
product: MODEL1310110019#

metaR NDPK3
fast: false
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000269
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
reactant: MODEL1310110019#

metaR r2106
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reactant: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM fadh2 r
initial amount: NaN
name: FADH2(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
type: Species
is: CHEBI:58307
is: HMDB01197
constant: false
boundary condition: false

metaM pi c
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:43474
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
name: hydrogenphosphate
is: SBO:0000247
initial concentration: 1.0
is: C00009
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110019#_e15a33ee_dd1f_4652_8a03_f43f6e4749be
constant: false
name: MLYCD
is: SBO:0000252
has only substance units: false
is: O95822
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:23417
initial amount: NaN

metaM lnlccoa m
constant: false
initial amount: NaN
name: linoleic coenzyme A
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
type: Species
has only substance units: false

metaR PROSTGE2t
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110019#
fast: false
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_200ddbe8_bfd6_4dd2_94d9_ac3cf72f336b
is: Q6ZWP6
type: Species
initial concentration: NaN
name: ACAD8
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR UMPK
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
name: UMP kinase
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#

metaR r0784
reactant: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is: SBO:0000176
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_40e5024b_3dbf_465a_a711_3233c7043188
has only substance units: false
name: NDUFB11
is: SBO:0000252
is: Q9NX14
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:54539
initial amount: NaN

metaR UDPGLCter
reactant: MODEL1310110019#
is described by: ECO:0000000
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_de073ed0_207a_4050_9c6c_2da242649521
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P48448
constant: false
is encoded by: hsa:222
type: Species
boundary condition: true
initial concentration: NaN
name: ALDH3B2

metaR CYANtm
type: Reaction
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#
fast: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM ala L e
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16977
initial concentration: 1.0
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
has only substance units: false
initial amount: NaN

metaR RE2649C
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
name: RE2649
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
fast: false
reversible: true

metaR r0021
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
reactant: MODEL1310110019#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176

metaR NDPK4
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
name: nucleoside-diphosphate kinase (ATP:dTDP)

metaM air c
type: Species
is: HMDB01235
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
boundary condition: false
initial amount: NaN
is: C03373
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: SBO:0000247

metaR r0783
is described by: ECO:0000000
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_436b60e5_c3e1_4c7a_9dfb_62dd104e41c2
has only substance units: false
name: _AA576959_1_c
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AA576959
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_1c0abf70_f59a_495a_a7c5_8e647e9029ae
constant: false
initial amount: NaN
name: ECHS1
type: Species
is: P30084
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1892
has only substance units: false

metaR DM fol
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_9f450b75_4804_43f7_96ab_bdf3e78dc0be
name: ENTPD3
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O75355
has only substance units: false
initial amount: NaN
is encoded by: hsa:956
constant: false

metaM udpgal g
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: CHEBI:58439
is: HMDB00302
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e4add595_377d_443b_a792_4274487d45b0
is encoded by: hsa:55902
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q5QPH3
name: ACSS2
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR MALSO3tm
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
product: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:28099

http://identifiers.org/biomodels.db/MODEL1310110019#_37fe427c_09a5_41c3_b00f_da2abba5c938
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2182
name: ACSL4
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: O60488

metaM 6dhf e
boundary condition: false
type: Species
name: hexaglutamyl folate (DHF)
has only substance units: false
is: HMDB06563
constant: false
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
initial amount: NaN

metaM 34hpp c
is: HMDB00707
boundary condition: false
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR OAADC
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_9e928695_8997_43f9_8b32_513e84940aae
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P31939
constant: false
type: Species
is encoded by: hsa:471
is: SBO:0000252
name: ATIC

metaR ACACT1rm
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000176
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
type: Reaction

metaM galside hs e
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247

metaM pi e
initial amount: NaN
is: CHEBI:43474
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: C00009
is: HMDB00973
initial concentration: 1.0
constant: false

metaM 3mop c
has only substance units: false
type: Species
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
initial concentration: 1.0
constant: false
is: CHEBI:28654
initial amount: NaN

metaR HIStN1
kinetic law: MODEL1310110019#
name: Histidine transport (Na, H coupled)
product: MODEL1310110019#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaR r2104
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#
fast: false

metaR NDPK5
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false

metaR FADH2tru
reversible: false
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110019#
product: MODEL1310110019#
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction

metaR r1156
kinetic law: MODEL1310110019#
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3e326d66_bf11_4a5c_ad96_35ac016c0f66
type: Species
has only substance units: false
is encoded by: hsa:51268
initial concentration: NaN
boundary condition: true
name: PIPOX
initial amount: NaN
constant: false
is: Q9P0Z9
is: SBO:0000252

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR r2109
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110019#_2bdb80e2_a62a_4113_a43c_c580a2933ddb
constant: false
name: _M68895_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:M68895
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_da465059_a6cb_4d59_8517_c76191ea9614
is encoded by: hsa:221823
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: PRPS1L1
initial concentration: NaN

metaR GPDDA1
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176

metaM HC01408 m
is: SBO:0000247
is: CHEBI:27648
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
name: 3-Oxohexanoyl-CoA

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM pi n
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00973
is: CHEBI:43474
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110019#_2000bbf3_a6bd_401b_8c49_c07e606a9f01
boundary condition: true
is encoded by: hsa:4539
is: Q7GXZ4
name: ND4L
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1642
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false

metaR RE3347C
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000176
name: RE3347

metaM CE5854 e
is: CHEBI:27485
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: gama-CEHC-glucuronide
is: HMDB02710

metaM fadh2 m
is: C01352
is: SBO:0000247
is: HMDB01197
boundary condition: false
is: CHEBI:58307
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
constant: false
has only substance units: false

metaM citr L m
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
name: L-citrulline
type: Species
is: HMDB00904
is: CHEBI:16349
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaM 2hb c
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
is: HMDB00008
is: CHEBI:1148
initial amount: NaN
type: Species

metaR SUCOASm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is described by: ECO:0000000
product: MODEL1310110019#
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
type: Reaction
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_933057eb_e69d_4499_ae98_8ece0f06cb7e
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: CMAS
boundary condition: true
is: Q8NFW8
initial concentration: NaN
is encoded by: hsa:55907

http://identifiers.org/biomodels.db/MODEL1310110019#_67aef2d5_ebe1_44df_aaa3_8787658d7276
is: Q15392
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1718
type: Species
name: DHCR24
initial concentration: NaN

metaR DM ethamp r
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_6c0fbdf6_4c56_4e6a_8c93_3ec4a00f7e3b
initial concentration: NaN
is encoded by: hsa:BE966236
name: _BE966236_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR r1643
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#
type: Reaction
reversible: true

metaR r0129
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110019#

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type: Species
has part: Q96I99
is: SBO:0000297
has only substance units: false
name: SUCLG2:SUCLG1
boundary condition: true
constant: false
is encoded by: hsa:8802
has part: P53597
initial amount: NaN
is encoded by: hsa:8801
initial concentration: NaN

metaM man c
is: SBO:0000247
is: C00159
initial amount: NaN
is: HMDB00169
initial concentration: 1.0
has only substance units: false
is: CHEBI:16024
constant: false
name: D-Mannose
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR NRPPHRt4 2 r
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Norepinephrine reversible transport in via sodium symport (1:2)
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_fd3a2eb9_7b0a_4e1b_80d0_8e802d6260ad
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:218
is: P30838
initial concentration: NaN
name: ALDH3A1
initial amount: NaN

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name: MYO5B
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4645
initial concentration: NaN
is: Q9H6Y6
initial amount: NaN

metaR r2107
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM cbasp c
constant: false
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
initial concentration: 1.0
is: HMDB00828
is: C00438
boundary condition: false
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
type: Species
initial amount: NaN
has only substance units: false

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boundary condition: true
is: P28329
type: Species
initial concentration: NaN
name: CHAT
is: SBO:0000252
constant: false
is encoded by: hsa:1103
has only substance units: false
initial amount: NaN

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is: Q86U05
name: SLC7A8
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:23428
initial amount: NaN
initial concentration: NaN
constant: false

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is: O75521
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10455
initial concentration: NaN
type: Species
boundary condition: true
name: ECI2
constant: false
has only substance units: false

metaR r1640
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_6d331409_948d_418f_bc57_329947ac8c25
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:26289
boundary condition: true
is: SBO:0000252
is: Q9Y6K8
name: AK5

http://identifiers.org/biomodels.db/MODEL1310110019#_132f3224_5d05_41eb_bb86_5d63e1e6b4b2
constant: false
initial concentration: NaN
boundary condition: true
is: A8K460
is: SBO:0000252
initial amount: NaN
name: PLA2G6
has only substance units: false
type: Species
is encoded by: hsa:8398

metaM 2hb e
has only substance units: false
is: HMDB00008
boundary condition: false
name: 2-Hydroxybutyrate
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
is: CHEBI:1148
initial concentration: 1.0

metaR RBFK
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
name: riboflavin kinase
reactant: MODEL1310110019#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.26
fast: false

metaR r2108
product: MODEL1310110019#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110019#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110019#

metaM ps hs m
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:18303
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[m]
initial concentration: 1.0

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type: Species
name: HSD17B4
is: E9PB82
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3295
has only substance units: false
boundary condition: true

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has only substance units: false
is encoded by: hsa:8781
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: _8781_1_c
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_7a4ad959_98ba_4d40_bc3c_26e65740376c
is encoded by: hsa:56623
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: INPP5E
is: Q9NRR6

http://identifiers.org/biomodels.db/MODEL1310110019#_b754338d_ecdf_43b2_9c21_371826c34b2b
initial amount: NaN
type: Species
constant: false
is: Q4W5N8
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51166
name: AADAT

metaR r1641
type: Reaction
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
product: MODEL1310110019#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR LEUGLYHYc
is described by: ECO:0000134
fast: false
reactant: MODEL1310110019#
is: SBO:0000176
type: Reaction
reversible: true
name: hydrolysis of leucylglycine
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110019#

metaM man e
is: C00159
initial amount: NaN
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaR PSt3
product: MODEL1310110019#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110019#
reversible: true
name: phosphatidylserine transport

metaR r0027
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110019#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176

metaM vitd3 c
type: Species
is: HMDB00876
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
initial amount: NaN
name: calciol
has only substance units: false
is: CHEBI:28940
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_6dd7a4c2_0252_4bf8_94a0_a38615461dc7
has only substance units: false
is encoded by: hsa:3157
name: HMGCS1
boundary condition: true
initial amount: NaN
constant: false
is: Q01581
is: SBO:0000252
initial concentration: NaN
type: Species

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is encoded by: hsa:8611
boundary condition: true
is: G3XA95
initial amount: NaN
name: PPAP2A
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_e71bfae7_bd3e_4756_a548_753939d9a980
constant: false
initial amount: NaN
name: RRM1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P23921
is encoded by: hsa:6240

metaM cys L c
constant: false
is: SBO:0000247
name: L-cysteine
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
is: CHEBI:17561
initial amount: NaN

metaM cdp c
is: C00112
type: Species
name: CDP
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58069
boundary condition: false
is: SBO:0000247
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
constant: false

metaM zymstnl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: HMDB06841
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5alpha-cholest-8-en-3beta-ol
constant: false
is: CHEBI:16608
initial concentration: 1.0
type: Species

metaR CHSTEROLt2
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
name: cholesterol intracellular transport
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR FRUt4
name: D-fructose transport via sodium cotransport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
reversible: true

metaR CYTK11
name: cytidylate kinase (dCMP,dGTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_9ebb1eaf_8cfb_4ddc_b2b9_c29861c8876f
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3636
constant: false
initial concentration: NaN
has only substance units: false
name: INPPL1
is: O15357

metaR RE1525M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE1525
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
product: MODEL1310110019#

metaM CE5786 e
is: HMDB02710
constant: false
is: SBO:0000247
type: Species
is: CHEBI:27485
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: kinetensin

http://identifiers.org/biomodels.db/MODEL1310110019#_1310d32d_dd3b_4f60_8aa6_6880215fd8c6
initial concentration: NaN
is encoded by: hsa:2987
is: Q16774
name: GUK1
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_18d65d6a_5bc2_4d27_b0eb_4a67d05f42b0
is: Q96PE7
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: MCEE
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84693

metaM so3 c
is: C00094
is: SBO:0000247
is: HMDB00240
type: Species
has only substance units: false
is: CHEBI:17137
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
initial amount: NaN
name: Sulfite
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_c0cf9e1b_e21c_4aad_afea_7b0206f2b443
constant: false
initial concentration: NaN
is: SBO:0000252
is: P28330
name: ACADL
has only substance units: false
boundary condition: true
is encoded by: hsa:33
type: Species
initial amount: NaN

metaR SUCOAS1m
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reactant: MODEL1310110019#

metaR r1381
fast: false
reversible: true
kinetic law: MODEL1310110019#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110019#

metaR RE1533M
kinetic law: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: RE1533
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM fpram c
is: SBO:0000247
is: C04640
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial concentration: 1.0
boundary condition: false
is: CHEBI:58478
constant: false
type: Species
is: HMDB06211
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

http://identifiers.org/biomodels.db/MODEL1310110019#_be05fd9d_1724_40d5_be9e_1275b3ec7a2b
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: GCK
boundary condition: true
initial concentration: NaN
constant: false
is: Q53Y25
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110019#_9c674a4d_b562_46c3_81ee_7aade5885f98
type: Species
is: P07864
boundary condition: true
initial concentration: NaN
name: LDHC
is encoded by: hsa:3948
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_72f09eb6_01f7_4312_9252_5073c41913db
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:7372
initial concentration: NaN
is: A8K5J1
name: UMPS
constant: false
initial amount: NaN
is: SBO:0000252

metaR PPNCL3
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110019#
name: phosphopantothenate-cysteine ligase
modifier: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269

metaR CHSTEROLt1
reversible: true
name: cholesterol intracellular transport
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110019#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reactant: MODEL1310110019#

metaR CYTK12
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP)
is: SBO:0000176

metaR PRASCS
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110019#
fast: false

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaM cdp e
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01546
initial concentration: 1.0
is: CHEBI:58069
boundary condition: false
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

metaR r1384
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110019#
type: Reaction

metaM cys L e
constant: false
is: SBO:0000247
type: Species
name: L-cysteine
initial concentration: 1.0
is: HMDB00574
boundary condition: false
is: CHEBI:17561
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false

metaR CYTK9n
modifier: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR DCK1n
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (ATP)
fast: false
kinetic law: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR EBP1r
product: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

metaR GALt1r
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
fast: false
type: Reaction
modifier: MODEL1310110019#
name: galactose transport (uniport)
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000269

metaR CERT1gt
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110019#
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110019#
name: ceramide transport protein
fast: false
reversible: true

metaR GTHDH
fast: false
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
name: Glutathione dehydrogenase (dehydroascorbate reductase)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_f9309817_3967_4698_a551_91ae29f724aa
type: Species
is: SBO:0000252
name: CPT1C
is: Q8TCG5
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:126129
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_7eed7c99_88fd_4d8d_b9da_961cb80241e2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10948
boundary condition: true
has only substance units: false
constant: false
is: B4DUY1
is: SBO:0000252
name: STARD3

metaR PSP L
reversible: false
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
name: phosphoserine phosphatase (L-serine)
is described by: ECO:0000269
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.3

metaR RE3006M
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false

metaM HC01406 m
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
is: SBO:0000247
is: CHEBI:28264
name: 3-Oxooctanoyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

metaR CHOLt4
product: MODEL1310110019#
name: choline, sodium cotransport
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false

metaM HC01602 c
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: C00234
is: CHEBI:57454
is: SBO:0000247

metaM pi m
initial amount: NaN
name: hydrogenphosphate
is: C00009
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false
type: Species
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110019#_04d06232_bd9f_4d5c_977f_ef5ca51ce0f9
name: _AI631997_1_m
is encoded by: hsa:AI631997
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR ASNTHRNaEx
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction

metaM icit c
name: Isocitrate
has only substance units: false
is: SBO:0000247
is: CHEBI:16087
initial concentration: 1.0
is: HMDB00193
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: C00311
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_f2433d69_805b_41cd_acb0_19bb3e230274
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2235
is: Q7KZA3
constant: false
type: Species
initial concentration: NaN
name: FECH
initial amount: NaN
boundary condition: true

metaR CYTK10
product: MODEL1310110019#
name: cytidylate kinase (CMP,dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110019#
is: SBO:0000176
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110019#

metaR RE1573M
is: SBO:0000176
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: RE1573
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110019#

metaR TYRTA
is described by: ECO:0000269
modifier: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
fast: false
reversible: true
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_8a5f8966_42a6_4934_9b4e_c5e529e65ad0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: _AI971036_1_c
is encoded by: hsa:AI971036

http://identifiers.org/biomodels.db/MODEL1310110019#_7e06a5c4_6796_4234_8fe5_e03a55a81958
boundary condition: true
initial concentration: NaN
name: HMOX2
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:3163
is: SBO:0000252
is: P30519
constant: false

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
is: CHEBI:15372
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
constant: false
is: HMDB00027
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaM bilirub e
is: CHEBI:57977
has only substance units: false
name: bilirubin(2-)
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
is: HMDB00054
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR MTHFD
is: SBO:0000176
product: MODEL1310110019#
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_14b6c506_0fb7_4b62_87a5_42774557f606
name: IMPDH1
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: B3KRZ3
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3614

metaM CE2420 m
boundary condition: false
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: CHEBI:28387
has only substance units: false
is: SBO:0000247
is: HMDB11123
initial concentration: 1.0
constant: false
initial amount: NaN

metaR OROTGLUt
type: Reaction
kinetic law: MODEL1310110019#
fast: false
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000134
name: OROTGLUt
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM sbt D c
has only substance units: false
constant: false
boundary condition: false
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
initial amount: NaN
is: CHEBI:17924
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 1p3h5c m
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r1633
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaR HISSNAT5tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1599
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM xolest2 hs e
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: cholesterol ester
is: CHEBI:17002
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_72ab5afd_8141_4652_a08a_5d18db1dd665
initial concentration: NaN
is encoded by: hsa:257202
is: P59796
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: GPX6
is: SBO:0000252

metaM chsterol r
type: Species
initial concentration: 1.0
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
is: HMDB00067
is: SBO:0000247
name: cholesterol
constant: false
has only substance units: false
boundary condition: false

metaR CYTK3n
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
reversible: true
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110019#
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_297a1e30_d0b5_42ee_a2b4_e0e20c94faac
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4722
constant: false
initial amount: NaN
is: O75489
type: Species
boundary condition: true
has only substance units: false
name: NDUFS3

metaR MTHFC
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110019#
is described by: ECO:0000134
name: methenyltetrahydrofolate cyclohydrolase
is: SBO:0000176

metaR LEUKTRF4t
is: SBO:0000185
product: MODEL1310110019#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110019#
fast: false
name: leukotriene F4 transport

http://identifiers.org/biomodels.db/MODEL1310110019#_178fce67_a83f_4a59_b4b7_e5a40ec46a2d
is: Q6FHI7
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:762
name: CA4
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR MTHFD2m
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_beb34c2e_8d51_40f0_8b94_f819a12e2c11
type: Species
initial amount: NaN
is: O00746
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4833
initial concentration: NaN
constant: false
name: NME4
boundary condition: true

metaR r0354
reactant: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
fast: false
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaM HC02214 e
is: CHEBI:28852
has only substance units: false
name: prostaglandin-f1alpha
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000

metaR r1632
is: SBO:0000185
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110019#
type: Reaction

metaR r0570
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
reactant: MODEL1310110019#

metaR ATP2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110019#
is: SBO:0000185

metaR RE0456M
reactant: MODEL1310110019#
is: SBO:0000176
name: RE0456
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
fast: false
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_5287504b_7605_4551_9102_838a22cc9838
initial amount: NaN
name: DEGS1
is: O15121
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8560
is: SBO:0000252

metaM rib D c
name: D-ribose
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16988
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0

metaR ORNt4m
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110019#
fast: false
reversible: true
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_495ab050_7ca0_491e_ae27_d46f3edfb64f
is: P28332
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:130
constant: false
name: ADH6
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_b8ca7070_ed34_404e_86d0_0bece4b46aeb
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI348006
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _AI348006_1_c

metaM amet c
constant: false
name: S-Adenosyl-L-methionine
is: CHEBI:15414
is: HMDB01185
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaR r0817
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is described by: ECO:0000000

metaR HMGCOASi
product: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
type: Reaction
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0b7aed14_0b98_48e8_9003_7aee8308e6e9
has only substance units: false
is encoded by: hsa:376497
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: SLC27A1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ce04c951_7d52_43d8_a0a5_2390ae6c9e37
initial concentration: NaN
constant: false
is encoded by: hsa:55349
is: Q8NE62
has only substance units: false
name: CHDH
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR r0603
kinetic law: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reactant: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110019#
is: SBO:0000176

metaR D LACt2
is described by: ECO:0000269
name: D-lactate transport via proton symport
reactant: MODEL1310110019#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000185

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
modifier: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#

metaR r0680
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110019#
is described by: ECO:0000000

metaR r0355
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
fast: false
product: MODEL1310110019#

metaR ACCOAtr
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
name: acetyl-coa transport
kinetic law: MODEL1310110019#
type: Reaction
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD

metaM frdp x
boundary condition: false
constant: false
is: HMDB00961
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: farnesyl pyrophosphate(3-)
is: CHEBI:175763
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM dhcrm hs c
has only substance units: false
is: CHEBI:31488
type: Species
boundary condition: false
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
name: dihydroceramide
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_9bc97c32_e2bd_43e8_97df_de4c093a7e90
type: Species
is encoded by: hsa:1854
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P33316
initial amount: NaN
constant: false
name: DUT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_888aa4c5_9d57_4ed4_8673_6f2de0e4f281
constant: false
boundary condition: true
is encoded by: hsa:3633
is: SBO:0000252
is: P32019
has only substance units: false
type: Species
name: INPP5B
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_50087dc7_b0c7_43ea_bbbb_5db1f360a75d
initial amount: NaN
is encoded by: hsa:131
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ADH7
is: P40394
has only substance units: false
type: Species

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR RE2973N
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
name: RE2973

http://identifiers.org/biomodels.db/MODEL1310110019#_be01513f_8935_4dde_a920_d238d8b12139
name: NME1:NME2
boundary condition: true
is: SBO:0000297
type: Species
has part: P22392
has part: P15531
has only substance units: false
is encoded by: hsa:4830
constant: false
initial amount: NaN
is encoded by: hsa:4831
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_8c23088b_9a4d_4f56_9cb3_94fec4330472
type: Species
name: CA2
constant: false
initial concentration: NaN
is: P00918
is: SBO:0000252
is encoded by: hsa:760
has only substance units: false
boundary condition: true
initial amount: NaN

metaR P5CDm
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110019#_818347b3_e758_46ae_8711_435c2715bcc1
type: Species
is: Q96SL4
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: GPX7
initial concentration: NaN
constant: false
is encoded by: hsa:2882

http://identifiers.org/biomodels.db/MODEL1310110019#_3fdc6f0a_4c54_4f9d_8b36_585e56eeb186
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _22305_2_c
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:22305

metaM retinol cis 13 c
is: SBO:0000247
initial amount: NaN
is: HMDB06217
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: 13-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
has only substance units: false
is: CHEBI:45479

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR CITtam
type: Reaction
is described by: ECO:0000269
name: citrate transport, mitochondrial
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false

metaR DURAD
kinetic law: MODEL1310110019#
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
reversible: true

metaR r2443
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110019#

metaR PEt
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110019#
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is: SBO:0000185
reversible: true

metaR CITRtm
type: Reaction
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110019#
fast: false
name: citrulline mitochondrial transport via proton antiport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#

metaR NODe
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110019#
name: NODe

metaM dmnoncrn x
type: Species
name: 4,8-dimethylnonanoyl carnitine
initial amount: NaN
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB06202
is: SBO:0000247

metaM glyc e
is: HMDB00131
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:17754
name: Glycerol

metaR MTHFDm
reversible: true
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000269
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110019#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_0f26243d_0a4c_4541_8131_b30008942487
boundary condition: true
has only substance units: false
name: SLC15A2
is encoded by: hsa:6565
is: Q16348
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR PYK
reversible: false
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
name: pyruvate kinase
reactant: MODEL1310110019#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
fast: false

metaM 2dr5p c
is: SBO:0000247
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
type: Species
has only substance units: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
boundary condition: false
is: CHEBI:57651
initial amount: NaN
constant: false
initial concentration: 1.0

metaR CSNAT3x
kinetic law: MODEL1310110019#
reversible: true
name: carnitine O-aceyltransferase, peroxisomal
is described by: ECO:0000269
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
type: Reaction

metaR r1637
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#

metaR FCLTm
kinetic law: MODEL1310110019#
name: Ferrochelatase, mitochondrial
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.99.1.1
reversible: false
product: MODEL1310110019#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096

metaM g6p c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
is: HMDB01401
is: CHEBI:61548
is: C00092
has only substance units: false
is: SBO:0000247

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM retinal 11 cis c
initial amount: NaN
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02152
type: Species
is: CHEBI:16066

metaM trdox m
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18191
initial amount: NaN
type: Species
has only substance units: false
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110019#_e4a20181_201b_442f_9db1_898cdf3cddc8
is: SBO:0000252
is encoded by: hsa:151531
is: O95045
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: UPP2
initial amount: NaN

metaR 3SPYRSP
is: SBO:0000176
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
reversible: false
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

metaM arachcoa e
name: arachidyl coenzyme A
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
constant: false
is: SBO:0000247
is: HMDB04258
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_1e58fe3c_fc7b_4a07_b8bd_fd7616baea8f
type: Species
is: P19961
is: SBO:0000252
is encoded by: hsa:280
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: AMY2B
constant: false

metaR UGALGTg
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110019#
is described by: ECO:0000134
type: Reaction
reversible: false
modifier: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus

metaR THRCYSNaEx
reversible: false
reactant: MODEL1310110019#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction

metaM dgmp m
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57673
is: HMDB01044
is: C00362

metaM cyan m
is: HMDB02084
is: SBO:0000247
boundary condition: false
name: hydrogen cyanide
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
is: CHEBI:18407

metaR r1636
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_b491cd21_86a3_426b_969f_de1912df0177
is: P48448
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDH3B2
is encoded by: hsa:222
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_c9906b38_8801_452f_ad57_ab7b9aa3a8ef
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5213
constant: false
is: SBO:0000297
has only substance units: false
name: PFKM:PFKP
has part: P08237
initial amount: NaN

metaM acac c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00060
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
name: acetoacetate
is: CHEBI:13705
is: SBO:0000247

metaM xylt c
type: Species
is: CHEBI:17151
is: HMDB02917
initial concentration: 1.0
name: xylitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r0604
kinetic law: MODEL1310110019#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176

metaR AMPtp
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110019#
name: AMP transporter, peroxisome
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR RE1342C
reactant: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
name: RE1342
type: Reaction
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_9bf6bb61_6122_45fa_bd4f_d60929655c4f
is: SBO:0000252
initial amount: NaN
is: Q68CJ7
constant: false
name: UROC1
initial concentration: NaN
is encoded by: hsa:131669
has only substance units: false
boundary condition: true
type: Species

metaR CYSGLNNaEx
reversible: false
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110019#

metaR r1639
reversible: true
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_35a69582_6f62_4e3b_90dd_5aba6d688c7c
constant: false
has only substance units: false
boundary condition: true
name: AMY2A
type: Species
initial amount: NaN
initial concentration: NaN
is: P04746
is: SBO:0000252
is encoded by: hsa:279

metaM xolest2 hs c
boundary condition: false
type: Species
is: SBO:0000247
name: cholesterol ester
has only substance units: false
initial concentration: 1.0
is: CHEBI:17002
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c4cc7f6f_c3ef_40ae_90e2_fb2e7c147d47
is encoded by: hsa:7371
is: Q9BZX2
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: UCK2
initial amount: NaN

metaM mmcoa S m
initial concentration: 1.0
name: (S)-methylmalonyl-CoA(5-)
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02310
is: CHEBI:57327
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
has only substance units: false

metaM sbt D e
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
name: D-glucitol
type: Species
is: SBO:0000247
constant: false
is: HMDB00247
initial concentration: 1.0

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449
has only substance units: false
constant: false
is: SBO:0000247
name: trans-3-decenoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_c4158bf2_f64c_4294_aa82_fc45eea01db4
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: NDUFB3
initial concentration: NaN
initial amount: NaN
is: Q6IB80
is encoded by: hsa:4709

http://identifiers.org/biomodels.db/MODEL1310110019#_03545e24_fa02_43f7_af8d_81a0b0e4a55e
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: CHKA
is encoded by: hsa:1119
boundary condition: true
has only substance units: false

metaM 4hoxpacd c
has only substance units: false
boundary condition: false
is: HMDB03767
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:15621
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765

http://identifiers.org/biomodels.db/MODEL1310110019#_a99e94d0_c60c_4187_9b13_51587bb4ce27
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23007
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: PLCH1
is: Q4KWH8

metaM urcan c
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
has only substance units: false
constant: false
is: SBO:0000247
name: Urocanate
is: CHEBI:17771
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00301
boundary condition: false

metaR LDH L
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase
fast: false
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaM nadph r
is: HMDB00221
is: SBO:0000247
constant: false
is: C00005
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57783
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_6298986d_77b8_49c9_8bef_782d939d9fb9
constant: false
type: Species
name: CTH
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P32929
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1491

metaR r1638
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_f733fb85_51a0_428a_afb1_2256abd7a50c
constant: false
is: SBO:0000252
has only substance units: false
is: P15104
initial amount: NaN
is encoded by: hsa:2752
name: GLUL
initial concentration: NaN
type: Species
boundary condition: true

metaM HC02214 c
initial amount: NaN
is: CHEBI:28852
name: prostaglandin-f1alpha
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
initial concentration: 1.0

metaM ibcoa m
has only substance units: false
initial amount: NaN
is: HMDB01243
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: isobutyryl-CoA(4-)
is: CHEBI:57338

metaR CHOLESACATc
is version of: http://identifiers.org/ec-code/2.3.1.26
reversible: false
type: Reaction
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000176
fast: false
name: esterification of cholesterol to cholesterol ester within enterocytes
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_6e1211cd_1ea5_4ecd_915c_424549add753
name: NMNAT2
boundary condition: true
is: Q9BZQ4
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:23057
has only substance units: false
initial concentration: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM HC02204 e
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27624
name: prostaglandin-b1

metaR r1591
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false

metaR r0960
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR BILIRUBtr
is: SBO:0000185
fast: false
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: lipid, flip-flop intracellular transport
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_ca4e22b0_edcb_4a9f_b21c_5ff288d323db
name: SLC38A2
is encoded by: hsa:54407
boundary condition: true
initial concentration: NaN
is: Q96QD8
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_d6f84331_0453_42ba_b02a_20aed8ad3a69
is: SBO:0000252
type: Species
initial amount: NaN
is: Q13825
is encoded by: hsa:549
name: AUH
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR DURIPP
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is described by: ECO:0000269
name: deoxyuridine phosphorylase
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a2ccb3e6_844c_41cd_9dce_10ea624d7e5f
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: CLYBL
boundary condition: true
is encoded by: hsa:171425

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR LSTO2r
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.21.6
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
reversible: false
name: Lathosterol oxidase
fast: false
modifier: MODEL1310110019#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110019#

metaM dc2coa m
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false
type: Species
initial amount: NaN
name: trans-Dec-2-enoyl-CoA
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61406

metaR RDH4
product: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: retinol dehydrogenase (13-cis,NADH)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT

metaR r1592
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_78965f2c_3f9c_489c_b431_a4bec2ba406b
constant: false
is encoded by: hsa:728441
has only substance units: false
name: GGT2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM lpchol hs c
type: Species
name: lysophosphatidylcholine
is: SBO:0000247
has only substance units: false
is: CHEBI:60479
constant: false
boundary condition: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaM HC01501 c
is: SBO:0000247
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
type: Species
has only substance units: false
is: CHEBI:33539
name: hydroxidodioxidosulfidosulfate(1-)
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM HC02204 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:27624
name: prostaglandin-b1
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9b5bfa69_5f7f_4374_87cc_420fd82b5352
is encoded by: hsa:2629
is: SBO:0000252
is: B7Z6S1
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110019#_635dd414_f6a6_449c_a1f3_bc04b296973c
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51733
name: UPB1
boundary condition: true
type: Species
initial amount: NaN
is: B3KNC1

metaR ASNGLNNaEx
reversible: false
kinetic law: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction

metaR r1527
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR r0060
product: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1d7d2dde_902f_4a32_87a2_44aeee11699c
type: Species
boundary condition: true
name: PRODH
constant: false
is: O43272
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5625

http://identifiers.org/biomodels.db/MODEL1310110019#_1ce9f758_94f3_456b_b4d4_3368fcd844c7
initial amount: NaN
is encoded by: hsa:29880
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: ALG5
boundary condition: true
is: Q9Y673

http://identifiers.org/biomodels.db/MODEL1310110019#_d092b5e2_d0bb_4cc2_852b_f95a33394315
is: Q5SPY7
initial concentration: NaN
is encoded by: hsa:954
name: ENTPD2
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR MMTSADm
fast: false
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#

metaM 5mthf c
is: CHEBI:3729
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00440
type: Species
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
constant: false
name: 5-Methyltetrahydrofolate

metaR r0575
fast: false
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_c913c73f_13d8_4981_9778_11950b7c79ca
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1103
name: CHAT
boundary condition: true
is: D3DX95

metaR r1593
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110019#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_2e568433_9bcb_4dcf_aead_713daaaad016
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: D3DX95
name: CHAT
boundary condition: true
is encoded by: hsa:1103

metaR O2tp
reversible: true
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
name: O2 transport, peroxisomal
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR PE HSter
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is described by: ECO:0000000

metaM chsterol l
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
is: CHEBI:16113
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00067
name: cholesterol

metaR RNDR2
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110019#
is described by: ECO:0000254
reversible: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: ribonucleoside-diphosphate reductase (GDP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_a2e2df69_a0b0_4a16_99ef_c8c1c18061e9
name: GMPR
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: P36959
initial concentration: NaN
is encoded by: hsa:2766
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_3b34dc7d_443d_4f06_9587_712d36c5e32e
is: SBO:0000252
name: ACPP
has only substance units: false
is encoded by: hsa:55
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: P15309
constant: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r2526
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reversible: true
fast: false

metaR r1594
reactant: MODEL1310110019#
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true

metaR DAGt
type: Reaction
product: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
name: diacylglycerol transport
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR LPS3
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.1.23
modifier: MODEL1310110019#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110019#
type: Reaction
name: lipase
fast: false
is: SBO:0000176
product: MODEL1310110019#

metaM CE2705 n
constant: false
is: CHEBI:15374
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB02281
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
name: quinonoid dihydrobiopterin

metaM acac e
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
type: Species
is: CHEBI:13705
initial concentration: 1.0
name: acetoacetate
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM lpchol hs e
initial concentration: 1.0
is: CHEBI:60479
boundary condition: false
type: Species
is: SBO:0000247
name: lysophosphatidylcholine
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110019#_da95fae2_97bb_4402_bbd1_cd9de2602ead
name: ENTPD8
is: Q5MY95
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:377841

metaR PCHOL HSter
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
name: phosphatidylcholine scramblase
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000
fast: false

metaR HMGLx
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is version of: http://identifiers.org/ec-code/4.1.3.4
reversible: false
product: MODEL1310110019#
type: Reaction
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3c5dc9a9_590d_4116_bc0f_db78f941e215
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P39877
initial amount: NaN
is encoded by: hsa:5322
name: PLA2G5
type: Species

metaR RNDR1
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (ADP)
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110019#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000254

metaM chsterol m
has only substance units: false
is: CHEBI:16113
initial concentration: 1.0
boundary condition: false
is: HMDB00067
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
type: Species

metaM 5mthf e
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
is: HMDB01396
is: C00440
boundary condition: false
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
constant: false
is: CHEBI:3729
has only substance units: false
initial amount: NaN

metaR r2525
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110019#
reversible: true
fast: false
is: SBO:0000185

metaR SCP22x
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: Sterol carrier protein 2
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110019#
is described by: ECO:0000000

metaM HC01412 m
has only substance units: false
is: CHEBI:61405
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false
initial amount: NaN
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM dgmp e
is: SBO:0000247
constant: false
type: Species
is: HMDB01044
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57673

http://identifiers.org/biomodels.db/MODEL1310110019#_ed6f3237_d5e2_4b59_b311_ecfb71f61fa8
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: NDUFB2
constant: false
is: H7C5B8
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4708

metaR LNLCCPT1
reversible: false
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_34c8ccb2_abcb_4b3d_832f_81feac11ef99
name: ND5
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4540
is: P03915
initial concentration: NaN
initial amount: NaN

metaR r1595
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_1f2b8270_ad44_42a0_85f3_dc4226451532
is: P53794
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6526
name: SLC5A3

metaM g1p c
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
constant: false
is: HMDB01586
is: CHEBI:58601
is: C00103
initial amount: NaN
name: D-Glucose 1-phosphate
type: Species

metaM acac m
type: Species
initial amount: NaN
is: CHEBI:13705
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
name: acetoacetate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00060

metaM glyc m
is: HMDB00131
is: CHEBI:17754
constant: false
boundary condition: false
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: C00116
is: SBO:0000247

metaR r2520
is: SBO:0000185
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false

metaR RNDR4
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (UDP)
reversible: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_d9afad9e_9959_46c4_98b3_78de9aa796c6
name: MDH2
is encoded by: hsa:4191
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P40926
has only substance units: false
type: Species

metaR HOMt4
is: SBO:0000185
name: L-homoserine via sodium symport
reactant: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110019#_890382fb_2522_426e_b43e_0f31a35221cb
name: SLCO3A1
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:28232
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9UIG8

http://identifiers.org/biomodels.db/MODEL1310110019#_37651b85_2f36_45c2_af31_32db3b77e9b5
is: SBO:0000252
boundary condition: true
name: PPA2
is: F8WDN9
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:27068

metaR LNLCCPT2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
name: carnitine transferase
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_ced9d6a8_83ff_4fb5_90aa_6da0393bcb46
initial concentration: NaN
has only substance units: false
name: ALDH1A3
boundary condition: true
is encoded by: hsa:220
is: SBO:0000252
constant: false
type: Species
is: P47895
initial amount: NaN

metaR r1596
reversible: true
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110019#

metaR RE3624M
reversible: false
modifier: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
kinetic law: MODEL1310110019#

metaR GGH 5DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
fast: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: false
type: Reaction
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR GGH 7DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
fast: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_797500cb_fb58_4ec0_9e08_356f2b7270b7
is: P49327
type: Species
name: FASN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2194
initial amount: NaN
initial concentration: NaN

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR DNDPt35m
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
reversible: false
modifier: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false

metaR RDH1
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110019#
name: retinol dehydrogenase (all-trans)
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR ACCOAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
name: acetyl-CoA transport, nuclear
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
reversible: true
type: Reaction

metaR GLCt4
modifier: MODEL1310110019#
reversible: true
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
is described by: ECO:0000269
name: glucose transport via sodium symport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reactant: MODEL1310110019#

metaM g1p e
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01586
initial concentration: 1.0
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)
is: CHEBI:58601
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species

metaR r1597
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_7e40e1a0_dc51_4227_858d_0992d0a975cc
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:375056
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q5JRA6
name: MIA3

metaR r0464
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reversible: true
reactant: MODEL1310110019#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
fast: false
product: MODEL1310110019#

metaR PFK
is described by: ECO:0000304
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is: SBO:0000176
reversible: false
name: phosphofructokinase
is version of: http://identifiers.org/ec-code/2.7.1.11
type: Reaction
kinetic law: MODEL1310110019#

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
type: Reaction
name: glycine N-choloyltransferase EC:2.3.1.65
kinetic law: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#

metaR CO2t
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: true
name: CO2 transporter via diffusion
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_11799211_d8c7_4ff3_b851_0cf6a6376fab
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: _D29675_1_e
is encoded by: hsa:D29675

metaR C4STMO2Pr
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
reversible: false
name: C-4 methyl sterol oxidase
reactant: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM xol7ah2al c
is: HMDB06894
is: CHEBI:27428
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
has only substance units: false
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true

metaR THP2Ctp
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaR PPCDC
type: Reaction
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269
modifier: MODEL1310110019#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR O2tm
reactant: MODEL1310110019#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false
name: O2 transport (diffusion)
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_a40fc84f_b813_42e0_808f_b2745394bda7
constant: false
is: SBO:0000252
name: _AA081045_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA081045
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_5046a9f2_5036_4b3a_8569_bce2279f8971
type: Species
name: OXSM
initial amount: NaN
is encoded by: hsa:54995
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9NWU1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_a9e081a2_6c87_44cb_9d2a_9c0ce5978c1f
constant: false
type: Species
boundary condition: true
name: LOXL2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4017
is: Q9Y4K0

metaR RDH3
is: SBO:0000176
name: retinol dehydrogenase (11-cis,NADH)
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_ea20971c_bd93_4447_a2e4_67a1a92e4462
initial concentration: NaN
constant: false
is encoded by: hsa:2348
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: FOLR1
type: Species
has only substance units: false

metaR r2521
product: MODEL1310110019#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
name: Utilized transport
reversible: true

metaR PVD3
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: Previtamin D3 formation
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

metaR SPHS1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
fast: false
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
product: MODEL1310110019#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

metaM dgchol c
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
name: glycochenodeoxycholate
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:36252
is: HMDB00637
type: Species

metaM CE2417 m
initial amount: NaN
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
type: Species
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false

metaR INSTt4 2
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
product: MODEL1310110019#
name: inositol transport via sodium symport
fast: false
is: SBO:0000185
is described by: ECO:0000006
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_6b43fa78_91bd_48b9_830b_ecccf2154cee
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4722
constant: false
name: NDUFS3
is: O75489
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM chsterol c
has only substance units: false
type: Species
is: CHEBI:16113
name: cholesterol
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067

metaR UMPK4n
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110019#
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_dbc7ea80_f0d1_48ff_9c8a_035101e113d7
initial amount: NaN
type: Species
is encoded by: hsa:210
is: SBO:0000252
boundary condition: true
is: Q6ZMU0
constant: false
has only substance units: false
initial concentration: NaN
name: ALAD

http://identifiers.org/biomodels.db/MODEL1310110019#_95a6aa42_80ae_495b_b427_0fd8d0f1325a
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: ALDH2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:217
is: P05091
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_0de09696_956e_4e1d_a6b6_2ba20a836d7e
name: FOLR1
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110019#_a78b64dc_e10b_4664_bc1d_abf9f45537e6
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:285973
is: Q674R7
initial concentration: NaN
constant: false
has only substance units: false
name: ATG9B

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: D-proline
is: HMDB03411
constant: false
is: CHEBI:16313
type: Species

metaR r0796
modifier: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is: SBO:0000176
product: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0e9bf0a2_5433_4042_a40a_d4663788d68e
is: O60331
boundary condition: true
type: Species
is encoded by: hsa:23396
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PIP5K1C
constant: false

metaR CBASPte
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of N-carbamoyl-L-aspartate
is described by: ECO:0000134
reversible: true

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d0965f01_87d2_408e_b062_253d4f24dab1
initial amount: NaN
boundary condition: true
is encoded by: hsa:124935
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: SLC43A2
is: Q8N370
initial concentration: NaN

metaM amet r
has only substance units: false
type: Species
is: CHEBI:15414
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-adenosyl-L-methionine
constant: false
initial amount: NaN
is: HMDB01185
boundary condition: false
initial concentration: 1.0

metaR ORNtiDF
type: Reaction
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
name: ornithine transport via diffusion (extracellular to cytosol)
fast: false
reversible: false
product: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaR ACACt2
fast: false
type: Reaction
modifier: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
name: acetoacetate transport via proton symport
is: SBO:0000185
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110019#
is described by: ECO:0000269

metaM asp L e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:29991
is: SBO:0000247
name: L-aspartate(1-)
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
is: HMDB00191
initial amount: NaN

metaM idp n
is: HMDB03335
name: IDP(3-)
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58280
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

http://identifiers.org/biomodels.db/MODEL1310110019#_49dd59f8_0f2f_44c0_b803_181d1a059af1
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFS8
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: O00217
is encoded by: hsa:4728

metaR r1431
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d55e485d_ded5_451e_988e_a6b353e710a5
initial concentration: NaN
constant: false
is: Q6FH11
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:3162
boundary condition: true
name: HMOX1

metaR MCLOR
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110019#
is: SBO:0000176
name: 3-Mercaptolactate:NAD+ oxidoreductase

metaR ETOHt
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: ethanol reversible transport
reactant: MODEL1310110019#
reversible: true
type: Reaction

metaM fald c
boundary condition: false
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
type: Species
is: HMDB01426
initial amount: NaN
constant: false
has only substance units: false
name: formaldehyde
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_13658c67_22e8_42b8_8414_d2213beccf6d
name: NDUFV2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4729
is: P19404
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR r0714
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110019#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_429b1197_1e09_41c0_93e4_be00181bff63
initial amount: NaN
name: _AL050025_1_c
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AL050025
has only substance units: false
is: SBO:0000252

metaR NADH2 u10m
name: NADH dehydrogenase, mitochondrial
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.6.99.3
is: SBO:0000185
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.6.5.3
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is described by: ECO:0000134
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_2acdd992_2269_4616_82cd_6bd20c911832
type: Species
name: PKM2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5315
is: B4DNK4

metaR r0795
reactant: MODEL1310110019#
name: Spontaneous reaction
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
reversible: false

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM Lpipecol x
initial concentration: 1.0
is: CHEBI:30913
is: SBO:0000247
constant: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial amount: NaN
boundary condition: false
name: L-pipecolic acid
is: HMDB00716
type: Species
has only substance units: false

metaM ade c
is: CHEBI:16708
boundary condition: false
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
initial amount: NaN
is: HMDB00034
initial concentration: 1.0
name: Adenine
has only substance units: false
is: SBO:0000247
is: C00147

http://identifiers.org/biomodels.db/MODEL1310110019#_1b1b5e62_b774_4e00_b1ed_d43c80cf9a1c
is: Q86WU2
name: LDHD
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:197257
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_22834680_550e_4df5_8f31_697a82afe91c
initial amount: NaN
name: _728637_1_c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:728637
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_d7fd99f8_8f7e_4a44_827f_cbba0860b159
initial amount: NaN
name: SLC6A9
is encoded by: hsa:6536
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: P48067
type: Species

metaM dgchol e
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
initial amount: NaN
is: CHEBI:36252
initial concentration: 1.0
is: HMDB00637
boundary condition: false
name: glycochenodeoxycholate
has only substance units: false
type: Species

metaM CE2421 m
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: SBO:0000247
type: Species
name: (3S)-3-hydroxylinoleoyl-CoA
is: HMDB02329
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is version of: http://identifiers.org/ec-code/2.4.2.7
modifier: MODEL1310110019#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#

metaM fdp c
constant: false
has only substance units: false
is: CHEBI:16905
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3647
initial concentration: 1.0
initial amount: NaN
is: HMDB01058
is: C00354
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
name: D-Fructose 1,6-bisphosphate

metaR TRDRm
modifier: MODEL1310110019#
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110019#

metaR GTHRDt
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: true
name: Glutathione transport into mitochondria
fast: false

metaM oaa x
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
is: CHEBI:16452
is: C00036
name: Oxaloacetate
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110019#_3f7f2d03_ca3d_4a6f_817d_82f6cf727474
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: COASY
is: Q13057
boundary condition: true
is encoded by: hsa:80347
initial amount: NaN
is: SBO:0000252

metaM ascb L e
is: CHEBI:38290
is: SBO:0000247
has only substance units: false
is: HMDB00044
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
name: L-ascorbate
constant: false
initial amount: NaN

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
is: CHEBI:16113
has only substance units: false
name: cholesterol
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00067
boundary condition: false

metaM ctp n
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
name: CTP(4-)
constant: false
initial concentration: 1.0
type: Species
is: HMDB00082
is: SBO:0000247
initial amount: NaN
is: CHEBI:37563
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_50be0d62_88ef_4c52_882f_ac08c2f51063
is encoded by: hsa:1609
type: Species
constant: false
is: P52824
initial amount: NaN
boundary condition: true
has only substance units: false
name: DGKQ
initial concentration: NaN
is: SBO:0000252

metaR r0130
is described by: ECO:0000000
modifier: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
type: Reaction
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

http://identifiers.org/biomodels.db/MODEL1310110019#_5fd1b224_4f56_4e6a_9fc0_39473db839ff
is: E9PB82
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3295
name: HSD17B4
initial concentration: NaN
constant: false
type: Species

metaM pro D e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
constant: false
boundary condition: false
is: CHEBI:16313
has only substance units: false
initial concentration: 1.0
type: Species
name: D-proline
is: SBO:0000247
initial amount: NaN

metaM pglyc hs c
boundary condition: false
initial amount: NaN
name: pglyc_hs[c]
notes: FORMULA: CHARGE: 0
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00156
initial concentration: 1.0
is: CHEBI:15589

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: CHEBI:16038
boundary condition: false
constant: false
name: phosphatidylethanolamine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_47b41d32_c661_4ce5_989d_65b972a012c8
name: ACAA1
is: SBO:0000252
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_9b8c8c83_d04a_4991_9aa1_09fb2b4e55ee
constant: false
initial amount: NaN
has only substance units: false
name: COX4I1
initial concentration: NaN
is: SBO:0000252
is: P13073
boundary condition: true
type: Species
is encoded by: hsa:1327

http://identifiers.org/biomodels.db/MODEL1310110019#_9ae6fae3_cd2d_4622_805f_27c553298b2d
type: Species
name: CA7
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q86YU0
is encoded by: hsa:766
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM 6a2ohxnt x
is: CHEBI:17534
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid
boundary condition: false
is: HMDB12151
initial concentration: 1.0
initial amount: NaN

metaR r0716
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110019#

metaR r1433
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reversible: true
reactant: MODEL1310110019#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
fast: false

metaR PI345P5P
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
is: SBO:0000176
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR DUDPtn
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: dUDP nuclear transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM dgmp c
is: SBO:0000247
name: dGMP
is: HMDB01044
boundary condition: false
constant: false
is: CHEBI:57673
initial concentration: 1.0
has only substance units: false
type: Species
is: C00362
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

http://identifiers.org/biomodels.db/MODEL1310110019#_04b2585a_4f94_45f2_a906_a73270fbea77
has only substance units: false
is encoded by: hsa:6575
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: SLC20A2
is: SBO:0000252
is: B2RBR4
initial amount: NaN

metaM andrstrn r
is: SBO:0000247
name: androsterone
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16032
type: Species
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
boundary condition: false
is: HMDB00031

http://identifiers.org/biomodels.db/MODEL1310110019#_6b1f6357_f5bd_463a_afaf_76c2fc643915
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AI345944
is: SBO:0000252
name: _AI345944_1_m
initial concentration: NaN
type: Species

metaR r1434
is: SBO:0000185
reactant: MODEL1310110019#
product: MODEL1310110019#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
reversible: false

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_943e3efe_b5bf_4e93_babf_e3558fecea6e
initial concentration: NaN
initial amount: NaN
type: Species
name: _U37519_1_m
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false

metaM glyb c
type: Species
is: HMDB00043
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
initial concentration: 1.0
name: glycine betaine
is: CHEBI:17750

http://identifiers.org/biomodels.db/MODEL1310110019#_1fce52de_3cc4_4fa6_bb48_f1054f79c661
is: SBO:0000252
name: NME1
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110019#_76697feb_a441_4012_80df_e4da47d04a00
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2747
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GLUD2
is: SBO:0000252
is: P49448

metaR r0245
is described by: ECO:0000000
modifier: MODEL1310110019#
reactant: MODEL1310110019#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110019#
fast: false
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176

metaM CE2839 e
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
has only substance units: false
name: maltodecaose
initial concentration: 1.0
initial amount: NaN
is: C01936
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5041

http://identifiers.org/biomodels.db/MODEL1310110019#_06d63372_b3cd_4c8d_8a5d_e942e2475f18
is encoded by: hsa:2582
is: Q14376
initial concentration: NaN
constant: false
type: Species
name: GALE
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ab5a82f5_3314_4a06_83de_5b014ea1ebd1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:314
is: O75106
has only substance units: false
name: AOC2
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR r2199
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_cd9c5ec7_849e_4ce2_aec2_fef7105d8508
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COX4I2
is: Q96KJ9
boundary condition: true
has only substance units: false
is encoded by: hsa:84701

http://identifiers.org/biomodels.db/MODEL1310110019#_eedaa6f4_12e7_4007_bfe8_3422ea1e635a
is: Q96T66
constant: false
is encoded by: hsa:349565
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: NMNAT3

metaM dcmp n
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
is: HMDB01202
is: CHEBI:57566
name: dCMP(2-)
constant: false
initial amount: NaN
is: SBO:0000247

metaR GTHPm
modifier: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
name: glutathione peroxidase, mitochondria
reactant: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
reversible: true
fast: false
product: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_efb1e52d_7695_4298_a9d8_2cc11a6af702
boundary condition: true
name: GCH1
type: Species
is encoded by: hsa:2643
initial amount: NaN
has only substance units: false
is: Q8IZH9
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r0791
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000000
modifier: MODEL1310110019#
type: Reaction
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110019#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_54e926b3_c2be_4fac_93dd_db393661e9fc
name: ACAA1:HSD17B4:ACOX1
is: SBO:0000297
has part: E9PB82
boundary condition: true
has part: B4DK61
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
has part: Q96CA6
initial amount: NaN
constant: false
is encoded by: hsa:30
is encoded by: hsa:3295

metaM CE4790 m
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57923
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial concentration: 1.0
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_a74030ca_00bc_4b24_bfaa_b8b3d9cee645
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _AA021081_1_r
initial concentration: NaN
is encoded by: hsa:AA021081
boundary condition: true

metaM glc D g
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
is: HMDB00122
initial concentration: 1.0
boundary condition: false
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110019#_379d3ebd_39a5_44c7_a705_9b7aacc2667b
constant: false
initial concentration: NaN
is: Q9Y6M9
is: SBO:0000252
type: Species
is encoded by: hsa:4715
initial amount: NaN
name: NDUFB9
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_90c8b281_de42_4310_b17f_6747de34075e
type: Species
boundary condition: true
is encoded by: hsa:6542
initial concentration: NaN
is: P52569
has only substance units: false
constant: false
name: SLC7A2
is: SBO:0000252
initial amount: NaN

metaR EX 34hpp
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR SPODMm
is described by: ECO:0000304
modifier: MODEL1310110019#
name: superoxide dismutase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110019#
reversible: false
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
product: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f05dec7b_1b6f_4f21_9a3b_46a260f8f5ad
is: O76082
initial concentration: NaN
initial amount: NaN
name: SLC22A5
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6584

metaM glyb e
boundary condition: false
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
is: HMDB00043
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:17750
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_1986f4bb_55aa_4238_9b49_cca795a800ac
name: PPA2
type: Species
initial amount: NaN
is: SBO:0000252
is: F8WDN9
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:27068

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_023f2427_9278_40ce_bc42_0ca88c5c4834
initial amount: NaN
constant: false
name: _AD000092_1_c
initial concentration: NaN
is encoded by: hsa:AD000092
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR THRALANaEx
modifier: MODEL1310110019#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110019#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d9e69f87_b22f_42ef_938c_435f68d73972
name: LHPP
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:64077
type: Species
is: Q9H008
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_bb24be9f_ccc4_4534_bb71_958386eca46e
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O00476
is encoded by: hsa:10786
has only substance units: false
constant: false
initial amount: NaN
name: SLC17A3

http://identifiers.org/biomodels.db/MODEL1310110019#_ddd6411c_c3e2_494b_9efc_37d677d3400a
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ALAS2
is encoded by: hsa:212
constant: false
is: Q5JZF5
type: Species

metaR RBTt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110019#
type: Reaction
name: ribitol transport via passive diffusion
product: MODEL1310110019#
fast: false
is: SBO:0000185
reactant: MODEL1310110019#

metaR CITt4 4
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is described by: ECO:0000006
type: Reaction
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD

metaM dgtp n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species
is: HMDB01440
is: SBO:0000247
is: CHEBI:16497
is: C00286
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_35e6c9df_4467_4325_adb6_25a87f845a66
is: Q15147
initial amount: NaN
is encoded by: hsa:5332
boundary condition: true
type: Species
name: PLCB4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ca47bc53_782f_4fb1_8db1_1e4b439f58b1
boundary condition: true
is: Q674R7
is: SBO:0000252
has only substance units: false
name: ATG9B
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:285973
initial concentration: NaN

metaM dctp c
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16311
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
has only substance units: false
is: C00458
is: HMDB00998
constant: false
is: SBO:0000247

metaM asp L c
type: Species
is: HMDB00191
initial amount: NaN
name: L-aspartate(1-)
is: SBO:0000247
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r0246
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110019#
fast: false

metaM glc D e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00122
is: CHEBI:4167
constant: false
name: D-glucose
type: Species
has only substance units: false
initial concentration: 1.0

metaM ade e
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: adenine
boundary condition: false
is: HMDB00034
is: CHEBI:16708
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_5de67b6d_b238_43ca_b431_96ba3a23aa26
has only substance units: false
name: SLC25A19
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:60386
is: Q9HC21
initial concentration: NaN

metaR ACALDtm
reversible: true
name: acetaldehyde mitochondrial diffusion
is described by: ECO:0000000
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
kinetic law: MODEL1310110019#
is: SBO:0000185

metaM xtsn c
initial concentration: 1.0
is: CHEBI:18107
constant: false
is: HMDB00299
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
name: xanthosine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_3858b996_6936_4dd1_8ae5_506d4dc8eba3
is encoded by: hsa:11181
name: TREH
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: O43280
initial amount: NaN

metaR r0579
product: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
modifier: MODEL1310110019#
fast: false
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_5f11e19b_ee20_43b4_a0fc_85634eab5cf0
initial amount: NaN
is: P82251
name: SLC7A9
boundary condition: true
has only substance units: false
is encoded by: hsa:11136
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaM triodthy e
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
is: HMDB00265
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18258
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
type: Species
constant: false

metaR CRNrtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
fast: false
type: Reaction
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_176f427d_340a_4afb_be3a_a8cf522129a6
constant: false
is encoded by: hsa:4714
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O95169
name: NDUFB8

metaM tdcoa m
is: HMDB01521
initial concentration: 1.0
is: C02593
is: SBO:0000247
is: CHEBI:57385
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaR TRPt
name: L-tryptophan transport
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR r2196
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110019#
reversible: true
is: SBO:0000185
reactant: MODEL1310110019#

metaM 4ppcys m
initial amount: NaN
is: CHEBI:59458
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species
is: SBO:0000247
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
is: CHEBI:57381
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: itaconyl-CoA(5-)
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_9d170b27_4832_45ed_9444_d4f70879b644
initial concentration: NaN
type: Species
constant: false
name: ACAD9
is: SBO:0000252
is: Q9H845
initial amount: NaN
is encoded by: hsa:28976
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_8fadeb92_3d4b_4649_bcf4_0139496cd9fb
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA664770
initial concentration: NaN
name: _AA664770_1_m
has only substance units: false
type: Species
boundary condition: true

metaR PItg
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
name: phosphate transport, Golgi apparatus
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false

metaR RE0926E
is: SBO:0000176
fast: false
product: MODEL1310110019#
name: RE0926
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_1307dfb3_7cac_4870_b890_846fc2db280f
initial amount: NaN
constant: false
is: B3KXY9
is encoded by: hsa:3098
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: HK1
initial concentration: NaN

metaM glc D c
name: D-glucose
initial amount: NaN
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00122
has only substance units: false
is: SBO:0000247

metaM lcts e
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
is: HMDB00186
is: SBO:0000247
constant: false
is: C00243
initial amount: NaN
is: CHEBI:17716
name: Lactose

http://identifiers.org/biomodels.db/MODEL1310110019#_b9ed3baa_dce9_4b09_9fa5_c7b5843ef5da
is encoded by: hsa:10568
type: Species
has only substance units: false
initial concentration: NaN
name: SLC34A2
is: O95436
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_f211eed8_1c3c_4f77_96c1_ddaf5eddedaa
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:137872
name: ADHFE1
is: Q8IWW8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_11149e6e_8777_4121_8611_8fe8800eb1d9
initial concentration: NaN
boundary condition: true
is: A8K7W0
initial amount: NaN
name: VNN2
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8875

metaR DCYTt
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
product: MODEL1310110019#
fast: false
type: Reaction
name: deoxycytidine transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110019#_1043f8f0_2e8f_41e4_ba6a_a1906d047bfb
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AI697028_1_m
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AI697028

metaR r2195
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110019#
product: MODEL1310110019#

metaM triodthy c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
is: HMDB00265
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_43133914_45f2_4fd2_8e08_020038ee6697
is encoded by: hsa:4723
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: E5KNH5
name: NDUFV1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9acfbeaf_bdff_48be_8d3f_7530a6dd55a8
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f58aa8a6_d30b_4705_a902_2836ba865f6c
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: HADHB
is: P55084
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3032

metaR UMPKm
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110019#
name: UMP kinase (mitochondrial, ATP)
fast: false
reversible: true
product: MODEL1310110019#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR UDPGALtg
product: MODEL1310110019#
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110019#
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
modifier: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_5d5d6733_7113_428c_a1ee_689ee0165304
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q6LEN5
name: CHAT
is encoded by: hsa:1103
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_ddcd799f_bbc6_4b87_b046_db08872d652f
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:3101
initial concentration: NaN
is: SBO:0000252
name: HK3
constant: false
is: P52790
boundary condition: true

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3233329a_1c65_468a_9199_379942eaad12
is encoded by: hsa:124454
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: EARS2
is: Q5JPH6

http://identifiers.org/biomodels.db/MODEL1310110019#_29f50008_3143_478e_b6b3_5556e2c26e0b
is: SBO:0000252
initial concentration: NaN
is: Q15758
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6510
name: SLC1A5
boundary condition: true
initial amount: NaN

metaR r2198
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
fast: false

metaM HC02121 c
constant: false
has only substance units: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
initial amount: NaN
is: CHEBI:58758
type: Species
boundary condition: false
initial concentration: 1.0
name: S-(hydroxymethyl)glutathione(1-)

http://identifiers.org/biomodels.db/MODEL1310110019#_9ee2ce17_dd95_4969_8265_91db28108906
initial concentration: NaN
type: Species
is: O14521
is encoded by: hsa:6392
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SDHD

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR DM atp c
type: Reaction
name: DM_atp(c)
product: MODEL1310110019#
is described by: ECO:0000134
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_30b92560_1516_4a4f_b85e_094d39e13496
is encoded by: hsa:2639
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: GCDH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_c555e37c_0123_4595_a074_2069b1836c56
constant: false
type: Species
boundary condition: true
has only substance units: false
name: COX6B1
initial amount: NaN
is: P14854
is: SBO:0000252
is encoded by: hsa:1340
initial concentration: NaN

metaR r0242
kinetic law: MODEL1310110019#
reversible: true
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
type: Reaction
modifier: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000

metaR r0688
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: true
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

metaR UMPKn
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110019#
name: UMP kinase, nuclear

metaR CERK
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
reversible: false
name: Ceramide kinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (64781.1) or (64781.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.7.1.138 Confidence Level: 4 AUTHORS: PMID:11956206 NOTES:NJ
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.138

metaR SUCD1m
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
type: Reaction
is described by: ECO:0000134
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: succinate dehydrogenase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110019#

metaM dgtp c
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: dGTP
is: C00286
is: CHEBI:16497
is: HMDB01440

metaR 1PPDCRp
kinetic law: MODEL1310110019#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal

metaR r1090
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: false
is described by: ECO:0000000
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110019#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_8f1110c8_5203_4eab_972f_a427e006b07b
is encoded by: hsa:AI924226
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: _AI924226_1_m

http://identifiers.org/biomodels.db/MODEL1310110019#_623a07db_9c68_4664_9c81_3bff306d9f42
constant: false
type: Species
initial amount: NaN
is: Q546Y9
initial concentration: NaN
is encoded by: hsa:57379
is: SBO:0000252
boundary condition: true
has only substance units: false
name: AICDA

metaM ctp e
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: CHEBI:37563
has only substance units: false
boundary condition: false
name: CTP(4-)
is: HMDB00082
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_b68cc630_7d8f_45e2_b6f6_980fa6c334fa
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI926493
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _AI926493_1_c

metaR r2197
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110019#_845abda5_17a9_436e_a87f_22fb92ca5190
type: Species
is: Q92911
initial amount: NaN
constant: false
is encoded by: hsa:6528
boundary condition: true
initial concentration: NaN
name: SLC5A5
has only substance units: false
is: SBO:0000252

metaR RE1517M
modifier: MODEL1310110019#
fast: false
reversible: true
name: RE1517
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000

metaR RE3005M
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: RE3005
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1147
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110019#
is: SBO:0000185
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM pram c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01128
has only substance units: false
is: CHEBI:58681
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
constant: false
is: C03090
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_5d076ec6_e55e_4600_afcc_8a0910cc36cb
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3939
has only substance units: false
constant: false
initial amount: NaN
name: LDHA
is: P00338
type: Species
is: SBO:0000252

metaM man6p c
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: D-Mannose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: CHEBI:17369
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01078

metaR CYTK10n
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (CMP,dGTP),nuclear
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM gthrd r
initial concentration: 1.0
is: CHEBI:57925
is: SBO:0000247
boundary condition: false
is: HMDB00125
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
constant: false
name: glutathionate(1-)
initial amount: NaN

metaR MALTSULtm
type: Reaction
is: SBO:0000185
name: Malate:thiosulfate antiport, mitochondrial
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110019#

metaR CPPPGO
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.3.3
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
kinetic law: MODEL1310110019#
name: coproporphyrinogen oxidase (O2 required)
modifier: MODEL1310110019#
is: SBO:0000176
reversible: false
reactant: MODEL1310110019#
type: Reaction
fast: false

metaM ascb L c
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:38290
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
type: Species
name: L-ascorbate

http://identifiers.org/biomodels.db/MODEL1310110019#_743389bd_37b1_4fc3_b89a_7f959949d843
name: ACADM
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:34
type: Species
is: P11310
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_45792386_f199_4881_aedb_9e59325407ef
is: P54687
constant: false
name: BCAT1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:586
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0434fb62_f6e2_45bd_bc8a_d50bdc0f98ed
is: B4DPV0
boundary condition: true
is encoded by: hsa:5236
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: PGM1
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_95e4ab53_43e1_47fd_8011_4686d7364a7f
initial amount: NaN
has only substance units: false
name: SLC7A1
is: SBO:0000252
is encoded by: hsa:6541
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: P30825

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR TCHOLAte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
name: bile acid intracellular transport
fast: false
product: MODEL1310110019#
type: Reaction
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR 2OXOADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
fast: false
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
name: 2-oxoadipate shuttle (cytosol/mitochondria)
is: SBO:0000185
reversible: true
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269

metaM dgtp e
has only substance units: false
is: CHEBI:16497
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01440
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
name: dGTP
constant: false

metaR r0139
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.2.2
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction

metaR SPHS1Ptr
type: Reaction
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
name: sphingosine-1-phosphate transport
reactant: MODEL1310110019#
product: MODEL1310110019#

metaM oaa m
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16452
has only substance units: false
is: C00036
name: Oxaloacetate
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
is: HMDB00223

metaM nadp c
type: Species
boundary condition: false
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
initial concentration: 1.0
is: C00006
is: CHEBI:58349
initial amount: NaN
is: SBO:0000247
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate

metaR RIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110019#
type: Reaction
fast: false
reactant: MODEL1310110019#
name: ribose transport via diffusion
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185

metaM biliverd c
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: biliverdin(2-)
is: HMDB01008
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
boundary condition: false
is: CHEBI:57991

metaR r2046
reversible: false
kinetic law: MODEL1310110019#
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_fa68fde4_9d28_40cd_b06c_fed2c2532552
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AI653169
constant: false
name: _AI653169_1_c
boundary condition: true

metaM rib D e
initial concentration: 1.0
is: HMDB00283
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
is: CHEBI:16988
constant: false
name: D-ribose
initial amount: NaN
boundary condition: false
type: Species

metaR CYSSNAT5tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_51755155_99f0_4c61_9b18_e332d3dcf2e9
has only substance units: false
initial amount: NaN
is: P31937
type: Species
is encoded by: hsa:11112
name: HIBADH
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_053a534f_a988_48c6_a7de_8236f3c7d3cf
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: NDUFS6
is: Q6IBC4
constant: false
initial amount: NaN
is encoded by: hsa:4726

metaM cholcoa c
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57373
boundary condition: false
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
name: choloyl-CoA(4-)
constant: false

metaM gthox c
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
is: C00127
initial concentration: 1.0
is: CHEBI:58297
name: Oxidized glutathione
has only substance units: false
is: SBO:0000247

metaR PSDm hs
kinetic law: MODEL1310110019#
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.65
reactant: MODEL1310110019#
modifier: MODEL1310110019#

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_505711a4_e4d7_43ae_a981_20cdc20398be
name: SLC22A3
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6581
type: Species
has only substance units: false
is: Q5SYN6

metaR GLCt1r
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110019#
reversible: true
kinetic law: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
name: glucose transport (uniport)

metaR r1630
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
product: MODEL1310110019#
is: SBO:0000185

metaR r2193
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_3dba9403_8cb5_4687_943f_8e3a7edc8df8
has only substance units: false
constant: false
initial concentration: NaN
name: ADH1A
is: P07327
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:124
is: SBO:0000252

metaM lthstrl r
boundary condition: false
is: HMDB01170
is: SBO:0000247
name: 5alpha-cholest-7-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17168

metaM trdox c
is: CHEBI:18191
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
type: Species
name: Oxidized thioredoxin
boundary condition: false
initial amount: NaN
is: C00343

metaR r2049
kinetic law: MODEL1310110019#
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_90a44be9_5668_4c6d_8528_60c45e7154ba
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
constant: false
is: P07864
name: LDHC
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00448
has only substance units: false
constant: false
type: Species
is: CHEBI:175763
name: Farnesyl diphosphate

http://identifiers.org/biomodels.db/MODEL1310110019#_762fe9d7_1dfb_4f74_aea7_e0f5902cbb86
is encoded by: hsa:956
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: ENTPD3
boundary condition: true
is: O75355

metaR r1631
product: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
reactant: MODEL1310110019#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_66996340_c85f_4ea3_bd6a_3b39d543abfd
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P31040
constant: false
name: SDHA
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110019#_ee7aebe3_40d4_49c9_a9c4_3f0b75dc87f1
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205
type: Species
name: AK4
has only substance units: false
is: SBO:0000252
is: P27144
initial amount: NaN

metaR HPACtr
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
product: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
name: hydroxyphenylacetate transport via diffusion
type: Reaction
fast: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_21cca36d_e24c_4978_9199_b8f8625b50a5
is encoded by: hsa:4952
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: OCRL
initial concentration: NaN

metaR RE1530C
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110019#
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR NDPK9n
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
fast: false
product: MODEL1310110019#

metaM fad r
name: Flavin adenine dinucleotide oxidized
type: Species
is: CHEBI:16238
constant: false
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_d920e66c_2557_4e9c_a56f_84dcb0a8d000
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:51022
type: Species
name: GLRX2
boundary condition: true

metaR CSNAT2m
modifier: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110019#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_8d120e37_87a6_449b_9d47_e49bce2fb2b5
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: P49619
initial amount: NaN
name: DGKG
is encoded by: hsa:1608
initial concentration: NaN
type: Species

metaM lcts g
is: HMDB00186
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: lactose
is: CHEBI:17716
initial amount: NaN
type: Species

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR NICRNS
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
kinetic law: MODEL1310110019#
reversible: false
type: Reaction
is: SBO:0000176
name: NICRNS
product: MODEL1310110019#
fast: false
is described by: ECO:0000000

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
product: MODEL1310110019#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110019#
modifier: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110019#

metaR ADK1m
modifier: MODEL1310110019#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
name: adenylate kinase, mitochondrial
is described by: ECO:0000269
type: Reaction
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110019#
fast: false

metaM retn e
constant: false
initial amount: NaN
is: CHEBI:35291
is: SBO:0000247
initial concentration: 1.0
is: HMDB01852
boundary condition: false
name: all-trans-retinoate
has only substance units: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777

http://identifiers.org/biomodels.db/MODEL1310110019#_cc263014_27a0_480a_8ab7_14dba66ad3c0
name: SLC24A3
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57419
is: Q9HC58
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_f480cde2_b15c_46be_bfd8_1a533018b2e2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1737
boundary condition: true
type: Species
name: DLAT
constant: false
initial amount: NaN
is: Q86YI5
initial concentration: NaN

metaR RE2972M
reversible: true
reactant: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110019#
name: RE2972
kinetic law: MODEL1310110019#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_326c2b92_d5d2_4d99_85f7_b16183774c56
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4129
name: MAOB
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P27338

metaR r2308
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_423cd0d4_c925_4a1f_abd1_938e52911543
is encoded by: hsa:LOC727762
is: SBO:0000252
constant: false
name: _LOC727762_1_m
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaM nadp r
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
has only substance units: false
is: HMDB00217
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
type: Species
is: CHEBI:58349
constant: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM glcur e
initial concentration: 1.0
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
constant: false
is: HMDB00127
boundary condition: false
name: D-glucuronate
type: Species
is: SBO:0000247

metaM ppi x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
name: Diphosphate
boundary condition: false
is: C00013
is: CHEBI:33019
type: Species
initial amount: NaN
constant: false

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR SMS
is version of: http://identifiers.org/ec-code/2.7.8.27
name: Sphingomyelin synthase (homo sapiens)
reactant: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110019#
type: Reaction
fast: false

metaR CYTK2n
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110019#
name: cytidylate kinase (dCMP),nuclear
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#

metaR r1623
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PPD2CSPp
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
name: PPD2CSPp
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000

metaR RE2660C
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
fast: false
reversible: true
is described by: ECO:0000000
name: RE2660

metaR r0502
fast: false
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113

metaR r0472
fast: false
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000000
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110019#
type: Reaction

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
has only substance units: false
is: CHEBI:59458
initial amount: NaN
initial concentration: 1.0
type: Species
is: C04352
is: HMDB01117
constant: false
boundary condition: false

metaM ach c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00895
constant: false
type: Species
initial amount: NaN
is: CHEBI:15355
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110019#_34b08af5_a130_49b4_800b_d9bebd76141a
boundary condition: true
constant: false
name: COX6B2
initial amount: NaN
is: Q6YFQ2
is encoded by: hsa:125965
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR NH4tp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: ammonia peroxisomal transport
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110019#

metaM fad m
boundary condition: false
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16238
initial amount: NaN
is: SBO:0000247
is: C00016

http://identifiers.org/biomodels.db/MODEL1310110019#_00aab45c_ab6e_4eda_b31f_70b8c0baae49
initial concentration: NaN
is: Q6NVY1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:26275
is: SBO:0000252
name: HIBCH
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_84deaf70_4a90_4c1a_86b4_a6bdd7cc7bd8
is: SBO:0000252
is: P31040
is encoded by: hsa:6389
boundary condition: true
initial amount: NaN
constant: false
name: SDHA
has only substance units: false
initial concentration: NaN
type: Species

metaM pail345p hs c
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
is: SBO:0000247
constant: false
is: CHEBI:57836
has only substance units: false

metaR r0580
product: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction

metaR r1622
kinetic law: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110019#

metaR PAIL4P HStn
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)

metaR GAMt1r
reversible: true
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: glucosamine transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110019#
is described by: ECO:0000269

metaM dctp n
is: HMDB00998
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00458
constant: false
type: Species
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
is: CHEBI:16311

metaM cpppg3 c
is: HMDB01261
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57309
name: Coproporphyrinogen III
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
initial amount: NaN
is: C03263
type: Species
boundary condition: false
has only substance units: false

metaR r0614
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reversible: true
fast: false
reactant: MODEL1310110019#

metaM 3otdcoa m
type: Species
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
is: HMDB03935
name: 3-Oxotetradecanoyl-CoA
constant: false
initial concentration: 1.0
is: CHEBI:28726
is: SBO:0000247
has only substance units: false

metaM dad 2 c
name: 2-deoxyadenosine
type: Species
is: HMDB00101
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:17256

metaR RPE
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase

metaM adn e
has only substance units: false
initial amount: NaN
is: C00212
type: Species
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: Adenosine
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00050

metaR RAI1
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: retinal isomerase (11-cis)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110019#

metaM udp r
name: UDP
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58223
is: C00015
initial amount: NaN
has only substance units: false

metaR ORNt3m
kinetic law: MODEL1310110019#
name: ornithine mitochondrial transport via proton antiport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM h2o2 x
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
constant: false
boundary condition: false
is: CHEBI:16240
initial concentration: 1.0
is: HMDB03125
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM C02528 r
constant: false
is: HMDB00518
is: CHEBI:36234
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: chenodeoxycholate
type: Species

metaM ditp c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
constant: false
has only substance units: false
is: HMDB03537
is: CHEBI:61382
is: SBO:0000247

metaR CERT1rt
reactant: MODEL1310110019#
is described by: ECO:0000304
modifier: MODEL1310110019#
name: ceramide transport protein
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reversible: true

metaR MI145PP
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
reactant: MODEL1310110019#
name: inositol-1,4,5-trisphosphate 5-phosphatase

metaR r1621
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110019#
product: MODEL1310110019#

metaR GRTTx
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110019#
product: MODEL1310110019#
fast: false
name: geranyltranstransferase
is: SBO:0000176
reactant: MODEL1310110019#
is described by: ECO:0000134
modifier: MODEL1310110019#

metaR O2St
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
name: superoxide anion transport via diffusion (extracellular)
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

metaR DSAT
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110019#
name: dihydrosphingosine N-acyltransferase
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reversible: false
product: MODEL1310110019#

metaR r0365
type: Reaction
product: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaM 7dhchsterol r
is: HMDB00032
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17759
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_944a3a4d_0660_4a0d_9988_b0a556913fc0
initial concentration: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
constant: false
is encoded by: hsa:7991
boundary condition: true
has only substance units: false
is: SBO:0000297
type: Species

metaM gthrd m
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57925
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
is: HMDB00125
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_983148dc_c742_4f4e_b5f6_f62e131fb592
initial amount: NaN
is: Q9UFY1
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5335
is: SBO:0000252
boundary condition: true
type: Species
name: PLCG1

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: HMDB01534
name: 5-Formiminotetrahydrofolate
is: C00664
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57456
is: SBO:0000247

metaM HC02203 c
is: SBO:0000247
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: prostaglandin-a2
boundary condition: false

metaM asp D c
name: D-aspartate(1-)
is: CHEBI:29990
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06483
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d1b2bae0_1d93_4f4d_b0bc_f104e9b57f28
name: HSD3B1
is: P14060
initial concentration: NaN
is encoded by: hsa:3283
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM ach e
name: acetylcholine
boundary condition: false
is: HMDB00895
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110019#_4356ba21_83f5_46c0_8b7f_e34ed303edea
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI915649
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AI915649_1_c
constant: false

metaR RAI2
reversible: true
name: retinal isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is: SBO:0000176
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_3efcd75f_a277_453b_a7fe_218dcb4d142a
initial amount: NaN
has only substance units: false
is encoded by: hsa:1346
boundary condition: true
constant: false
name: COX7A1
is: P24310
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_937fb57d_c12d_41cc_bac3_b7662acae4e9
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:205
name: AK4
boundary condition: true
is: SBO:0000252

metaM 4mop m
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
constant: false
is: CHEBI:17865
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: HMDB00695
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_97b34eb2_c5c8_4cb1_9034_e26156f01473
initial amount: NaN
initial concentration: NaN
is: P17812
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:1503
type: Species
has only substance units: false
name: CTPS1

metaR r1620
reactant: MODEL1310110019#
is: SBO:0000185
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_51ebb231_9713_4c7b_95d9_116c45e23891
has only substance units: false
boundary condition: true
is: C9JT23
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: NDUFA11
is encoded by: hsa:126328

metaR FORt2m
reversible: true
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
name: formate mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
is: SBO:0000185
type: Reaction
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_40f922b1_0a18_41d1_a1c9_c563b0432a16
name: PPA2
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:27068
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d3022bd2_903f_4e50_88f9_34541ddff55c
is encoded by: hsa:4729
is: SBO:0000252
is: P19404
has only substance units: false
constant: false
initial amount: NaN
name: NDUFV2
initial concentration: NaN
boundary condition: true
type: Species

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_c4b84f62_afa3_420b_a2f7_cd197a276ec9
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: BDH1
initial concentration: NaN
is encoded by: hsa:622

http://identifiers.org/biomodels.db/MODEL1310110019#_a3109d0c_f1e3_4332_b660_6b369190667e
is: SBO:0000252
is encoded by: hsa:3418
name: IDH2
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: P48735
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_027d9a9a_c34d_4088_ab5c_56e63954e47c
type: Species
boundary condition: true
initial amount: NaN
is: Q6IB80
has only substance units: false
initial concentration: NaN
name: NDUFB3
is: SBO:0000252
constant: false
is encoded by: hsa:4709

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30860
initial amount: NaN
name: Methylmalonate

http://identifiers.org/biomodels.db/MODEL1310110019#_01037842_7983_4816_af38_7fa6677c6b03
initial concentration: NaN
type: Species
name: DHODH
is encoded by: hsa:1723
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q02127

metaM udpg c
is: C00029
type: Species
constant: false
name: UDPglucose
is: CHEBI:58367
boundary condition: false
is: HMDB00286
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false

metaM gthox m
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB03337
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
is: SBO:0000247
boundary condition: false

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110019#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110019#

metaM nad x
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
constant: false
initial concentration: 1.0
is: C00003
is: HMDB00902

metaR STCOAtx
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110019#
reversible: true
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM pnto R c
boundary condition: false
initial concentration: 1.0
is: CHEBI:7916
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
name: (R)-Pantothenate

metaM lnlc c
boundary condition: false
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: linoleate
is: HMDB00673
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_cb6fd756_9582_4a71_9161_25b4e61d4586
boundary condition: true
is: O14880
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: MGST3
is encoded by: hsa:4259
initial amount: NaN

metaR HACD9m
is: SBO:0000176
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reversible: true
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
initial amount: NaN
constant: false
is: SBO:0000247
name: prostaglandin-a2
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM nadp m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
constant: false
initial amount: NaN
is: C00006
is: HMDB00217
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species

metaM ivcoa m
is: SBO:0000247
type: Species
is: CHEBI:57345
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
name: Isovaleryl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01113

metaR r1627
is: SBO:0000185
product: MODEL1310110019#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaM oaa c
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: Oxaloacetate
boundary condition: false
is: HMDB00223
is: C00036
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0

metaR CSNATm
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: carnitine O-aceyltransferase, mitochondrial
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
product: MODEL1310110019#
is: SBO:0000176
fast: false
reactant: MODEL1310110019#

metaM prostgh2 c
is: CHEBI:57405
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
is: SBO:0000247
name: prostaglandin H2(1-)

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_0da352ed_e67d_4a82_8429_b090573cde66
boundary condition: true
name: FOLR3
is encoded by: hsa:2352
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: Q05C14
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_4ecf4d7e_405e_4711_a8f3_8e6b9c673c98
has only substance units: false
type: Species
name: PYCR1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P32322
is encoded by: hsa:5831
initial concentration: NaN

metaM asp D e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:29990
is: SBO:0000247
name: D-aspartate(1-)
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
constant: false
is: HMDB06483

metaR r0618
reactant: MODEL1310110019#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
product: MODEL1310110019#
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110019#_79eb3fac_4e55_4e0b_bf94_805ce23fd351
boundary condition: true
is: SBO:0000252
name: IDH2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3418
initial amount: NaN
initial concentration: NaN
is: P48735

http://identifiers.org/biomodels.db/MODEL1310110019#_a56e458a_975a_4b05_a9ae_be70ac71d080
is: SBO:0000252
constant: false
is encoded by: hsa:30
has only substance units: false
initial amount: NaN
type: Species
name: ACAA1
is: Q96CA6
boundary condition: true
initial concentration: NaN

metaM pheme m
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: HMDB03178
boundary condition: false
initial concentration: 1.0
is: C00032
constant: false
initial amount: NaN
name: Protoheme
is: CHEBI:17627
is: SBO:0000247
type: Species

metaR PHCHGSm
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
product: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_b37c4450_03f3_4459_807c_b0aa0531b6c4
constant: false
boundary condition: true
is: SBO:0000252
is: Q99798
initial concentration: NaN
type: Species
name: ACO2
initial amount: NaN
has only substance units: false
is encoded by: hsa:50

metaM CE4792 m
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
constant: false
type: Species
has only substance units: false

metaM udp n
is: HMDB00295
is: CHEBI:58223
is: SBO:0000247
constant: false
has only substance units: false
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r1626
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_00c696fb_6cb8_49d1_a804_4d005d8c5ad3
initial concentration: NaN
type: Species
name: _AA614647_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:AA614647
is: SBO:0000252
constant: false
initial amount: NaN

metaM pac c
is: CHEBI:18401
is: HMDB00209
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: phenylacetate

metaM ctp c
has only substance units: false
type: Species
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00082
initial amount: NaN
initial concentration: 1.0
name: CTP
is: C00063

metaM udpg e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367
initial concentration: 1.0

metaM ppi r
name: Diphosphate
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: C00013
is: HMDB00250
is: CHEBI:33019

http://identifiers.org/biomodels.db/MODEL1310110019#_f095aac2_6497_4064_af21_2713a06d9e70
initial amount: NaN
name: SLC40A1
type: Species
constant: false
is encoded by: hsa:30061
is: SBO:0000252
boundary condition: true
is: Q9NP59
initial concentration: NaN
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR RPI
name: ribose-5-phosphate isomerase
is: SBO:0000176
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110019#

metaM udp m
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: UDP(3-)
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295

metaM pnto R e
name: (R)-Pantothenate
boundary condition: false
initial concentration: 1.0
is: CHEBI:7916
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_536da1a5_2c73_4002_8378_28c34329d445
type: Species
is encoded by: hsa:7108
has only substance units: false
constant: false
initial concentration: NaN
name: TM7SF2
boundary condition: true
is: SBO:0000252
is: O76062
initial amount: NaN

metaR RE1807C
product: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
name: RE1807

http://identifiers.org/biomodels.db/MODEL1310110019#_66f5f75f_3a64_40c1_a2ad_f022e6afaeaa
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5332
name: PLCB4
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: E2QRH8

http://identifiers.org/biomodels.db/MODEL1310110019#_c29fd278_73f6_4063_99e1_1150b43e16c0
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: PCK2
is: SBO:0000252
is encoded by: hsa:5106
constant: false
boundary condition: true
is: Q16822

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27555
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_a3883ecf_35ab_444a_9415_ad5875aef429
constant: false
name: NDUFA5
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4698
is: Q16718
is: SBO:0000252

metaR r1625
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110019#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_f2e8d40a_c848_4b9a_8181_d5e3c67a5213
is: Q7GXY8
has only substance units: false
constant: false
is encoded by: hsa:4512
boundary condition: true
initial concentration: NaN
type: Species
name: COX1
initial amount: NaN
is: SBO:0000252

metaR CDS
modifier: MODEL1310110019#
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: phosphatidate cytidylyltransferase
reversible: false
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176
reactant: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_58c23388_e069_4144_9d2c_318020e6ab95
has only substance units: false
constant: false
is: Q6FGA0
is encoded by: hsa:9167
is: SBO:0000252
boundary condition: true
name: COX7A2L
initial amount: NaN
type: Species
initial concentration: NaN

metaR HEX10
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucosamine:ATP)
is: SBO:0000176
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
reversible: false
reactant: MODEL1310110019#

metaM C05957 r
is: CHEBI:27485
is: HMDB02710
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: Prostaglandin J2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
constant: false
is: SBO:0000247

metaM xu5p D c
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial amount: NaN
boundary condition: false
is: HMDB00868
is: CHEBI:57737
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM fum m
is: HMDB00134
is: C00122
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:29806

http://identifiers.org/biomodels.db/MODEL1310110019#_7644b7ba_5104_49dd_9eac_ffd81145f7ae
is: Q99624
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10991
type: Species
name: SLC38A3
initial amount: NaN

metaR r0616
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_56210f66_5d1c_4026_a18b_ea0cc1426fac
boundary condition: true
constant: false
has only substance units: false
is: O43677
name: NDUFC1
initial concentration: NaN
type: Species
is encoded by: hsa:4717
is: SBO:0000252
initial amount: NaN

metaM ahcys c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16680
initial amount: NaN
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
type: Species
name: S-Adenosyl-L-homocysteine
constant: false
is: C00021
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d9ad5a5a_a4bd_41f6_9ae6_996fd8d40712
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: A0PJJ9
name: GGT7
boundary condition: true
is encoded by: hsa:2686

metaR BHBt
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV

metaR MI145PK
reactant: MODEL1310110019#
fast: false
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_167042e2_3839_452c_a720_4a4a319fb6ca
has only substance units: false
is: SBO:0000252
constant: false
is: Q9BQG2
name: NUDT12
is encoded by: hsa:83594
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR FE3R2e
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
reactant: MODEL1310110019#
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
name: Fe(III) reduction (ascorbate)

metaR DHCRD2
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
modifier: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_0cc1ee49_6f87_4f6c_8222_f39d89cd70e0
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: _AA526438_1_c
is encoded by: hsa:AA526438
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_dc5df971_403c_4138_877f_e38a12be1d07
type: Species
is: Q6IA69
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:55191
name: NADSYN1

http://identifiers.org/biomodels.db/MODEL1310110019#_c2280185_b191_4d71_b0ad_67f4f44d745d
constant: false
initial concentration: NaN
is: SBO:0000252
is: E2QC23
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:23464
type: Species
name: GCAT

http://identifiers.org/biomodels.db/MODEL1310110019#_2b1a993a_3885_4298_b73b_c23167feeecb
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220
boundary condition: true
constant: false
is: P47895
is: SBO:0000252
name: ALDH1A3
has only substance units: false
type: Species

metaR r1624
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR MI134PP
kinetic law: MODEL1310110019#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.57
is described by: ECO:0000269
product: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
name: inositol-1,3,4-trisphosphate 1-phosphatase

metaR CSNAT2x
is described by: ECO:0000269
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110019#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
kinetic law: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_e4d1a76d_4a9f_42fe_944a_00407d7e932b
name: PLCB1
is: Q9NQ66
constant: false
has only substance units: false
type: Species
is encoded by: hsa:23236
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM fad e
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: C00016
is: HMDB01248
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: CHEBI:16238

metaR r1291
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110019#
name: Postulated transport reaction
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction

metaR 34DHOXPEGt
reversible: true
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
fast: false
is: SBO:0000185
product: MODEL1310110019#
is described by: ECO:0000000
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)

metaR r0587
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reversible: true
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
modifier: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
fast: false

metaR BTNt4i
reactant: MODEL1310110019#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110019#
name: Biotin uptake (antiport)
reversible: false
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
is described by: ECO:0000269

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_377e27e5_6cb1_4d90_b587_51bc00370caa
name: _AI191472_1_c
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI191472
is: SBO:0000252

metaR r1429
kinetic law: MODEL1310110019#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
name: Free diffusion
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaR CSNATp
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110019#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
kinetic law: MODEL1310110019#
is described by: ECO:0000304
is: SBO:0000176

metaM glc D r
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
initial concentration: 1.0
type: Species
is: HMDB00122
constant: false
boundary condition: false
name: D-glucose
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_a3954163_fc6c_4bc9_9551_8f0d016efaaf
is encoded by: hsa:FLJ44968
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _FLJ44968_1_m
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_86aae66f_03c6_4dfb_8397_e86f80750940
is: SBO:0000252
name: ABP1
initial amount: NaN
is: P19801
is encoded by: hsa:26
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM glu L m
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: L-glutamate(1-)

metaR RETt
reactant: MODEL1310110019#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_b8b2bfc6_cdf1_41ed_89e7_ce0ae6163529
boundary condition: true
is encoded by: hsa:H17063
initial concentration: NaN
name: _H17063_1_c
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR CYSt4
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
name: L-cysteine reversible transport via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110019#
reversible: false
is: SBO:0000185

metaR r1292
kinetic law: MODEL1310110019#
name: Postulated transport reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reversible: true
fast: false

metaR ASPTA
type: Reaction
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000176
fast: false
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reversible: true
is described by: ECO:0000269

metaR r0360
type: Reaction
kinetic law: MODEL1310110019#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#

metaR RETNGLCt2
type: Reaction
kinetic law: MODEL1310110019#
reversible: false
is: SBO:0000185
reactant: MODEL1310110019#
fast: false
name: retinoyl glucuronide efflux (13-cis)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:14704335,PMID:2324641 NOTES:IT
product: MODEL1310110019#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR CYSTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176
name: cysteine transaminase
reversible: true
product: MODEL1310110019#
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.6.1.1

metaM thyox L c
type: Species
is: SBO:0000247
is: CHEBI:18332
initial concentration: 1.0
is: HMDB00248
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine

metaR r1428
product: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
name: Free diffusion
reactant: MODEL1310110019#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_d7c67f60_047b_47a9_aba1_8b48127b19b1
is encoded by: hsa:2181
initial amount: NaN
is: O95573
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: ACSL3

metaM utp n
is: SBO:0000247
type: Species
is: HMDB00285
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:46398
name: UTP(4-)
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false

metaR MMSAD3m
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110019#
is described by: ECO:0000269
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
modifier: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD

metaM glyclt x
is: HMDB00115
constant: false
is: CHEBI:29805
is: SBO:0000247
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
boundary condition: false
initial amount: NaN
name: glycolate
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_29efbe20_9ac0_40c6_bb0c_b99dca9014db
has only substance units: false
name: ALDH7A1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:501
is: E7EPT3
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_cfb00c4c_5bd7_4b73_98bb_78c81c690007
initial concentration: NaN
is: P36269
type: Species
name: GGT5
constant: false
is: SBO:0000252
is encoded by: hsa:2687
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_06aa4ae0_ca4a_420c_922b_da6e14351f83
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5198
is: Q6P4B4
name: PFAS
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR GGT6
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Gamma-glutamyltransferase
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_103fbfee_5c88_41f5_91e4_f87c43fa7622
initial amount: NaN
is encoded by: hsa:4357
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P25325
has only substance units: false
name: MPST
constant: false
type: Species

metaM gthrd e
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
is: HMDB00125
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57925
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR SERASNNaEx
is: SBO:0000185
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
type: Reaction

metaM fad c
is: CHEBI:16238
is: C00016
is: HMDB01248
boundary condition: false
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR RE3272N
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
fast: false
is described by: ECO:0000000
name: RE3272
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
type: Reaction

metaM 2mp2coa m
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial amount: NaN
has only substance units: false
is: CHEBI:27754
type: Species
name: 2-Methylprop-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01011

metaM retinal c
constant: false
is: SBO:0000247
has only substance units: false
name: retinal
type: Species
is: HMDB01358
is: CHEBI:15035
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0
initial amount: NaN

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110019#
type: Reaction
is: SBO:0000176
fast: false
name: dUTP diphosphatase, nuclear
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_f88a03ae_07b2_40f7_a822_f85f011952d8
is: B7Z2M9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8525
type: Species
name: DGKZ
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_6ba5781a_5eb5_486b_a067_97f88a175ad4
is encoded by: hsa:8525
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: G3V0F6
name: DGKZ
is: SBO:0000252

metaM ppi n
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00250
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:33019
name: diphosphate(3-)

metaR r1427
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#

metaM CE0693 m
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
constant: false
has only substance units: false
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB11123

metaM utp m
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:46398
name: UTP(4-)

metaR r1629
reactant: MODEL1310110019#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR MMEm
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.1.99.1
kinetic law: MODEL1310110019#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
is: SBO:0000176
name: methylmalonyl-CoA epimerase/racemase

metaR ASCBt4
name: L-ascorbate transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
reactant: MODEL1310110019#
type: Reaction
is: SBO:0000185
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_d5795126_8edc_4085_ad6b_b63c594f4b08
name: ADH1A:ADH1B
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:125
is: SBO:0000297
has part: P07327
has part: P00325
is encoded by: hsa:124

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM dmnoncrn c
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
is: HMDB06202
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR FADH2ETC
name: Complex II reaction for respiratory chain
reactant: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is described by: ECO:0000134
reversible: false
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_a9a90c7b_8df2_4042_a1cc_e8e34443feb5
is: SBO:0000252
name: FDFT1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P37268
initial amount: NaN
is encoded by: hsa:2222
type: Species

metaM 4mop e
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00695
boundary condition: false
constant: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
has only substance units: false

metaM ach n
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: CHEBI:15355
type: Species
name: acetylcholine
initial concentration: 1.0
is: HMDB00895
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b42d595d_a168_4e2c_8d4c_c1068f890fd8
type: Species
initial amount: NaN
constant: false
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
is: SBO:0000297
initial concentration: NaN
has part: E5KS60
has only substance units: false
boundary condition: true

metaR r2511
product: MODEL1310110019#
name: Utilized transport
kinetic law: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reactant: MODEL1310110019#
reversible: true
fast: false
is: SBO:0000185

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR PIt7
product: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110019#_a9ad0002_df04_408c_94dc_d97af7a817f3
constant: false
boundary condition: true
is: D9HTE9
name: SLC25A1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110019#_0fc6c051_f983_4e52_bb26_bd2984e597de
initial amount: NaN
constant: false
type: Species
is: Q7GXZ8
initial concentration: NaN
is encoded by: hsa:4513
boundary condition: true
is: SBO:0000252
name: COX2
has only substance units: false

metaM frdp c
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: HMDB00961
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Farnesyl diphosphate
is: C00448
initial amount: NaN

metaR DOLGPP Ler
product: MODEL1310110019#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110019#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110019#
is described by: ECO:0000000

metaM pheme e
is: CHEBI:17627
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
constant: false
is: C00032
is: HMDB03178
initial amount: NaN
type: Species
name: Protoheme

metaR RE1807M
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110019#
name: RE1807

metaM HC02213 c
constant: false
name: prostaglandin-e3
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110019#_59feae88_dc45_4281_b7f0_e557cdddb4cc
is encoded by: hsa:10587
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: TXNRD2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_044d22cc_cff7_4076_aee3_71fd06a816df
is: SBO:0000252
is encoded by: hsa:4705
initial amount: NaN
constant: false
is: O95299
initial concentration: NaN
name: NDUFA10
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_d5db5cb2_1c3a_414b_8e1d_f73aa4923037
is: Q9Y5B8
is encoded by: hsa:29922
name: NME7
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3e3b7588_7e4d_4871_b8f2_0ded92ce97bc
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: PLCL1
boundary condition: true
has only substance units: false
is: Q15111
constant: false
is encoded by: hsa:5334

http://identifiers.org/biomodels.db/MODEL1310110019#_edbe818a_6c83_4545_a992_72f5ce4938e8
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P37268
name: FDFT1
boundary condition: true
is encoded by: hsa:2222
initial concentration: NaN

metaM dcholcoa r
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
constant: false
type: Species
initial amount: NaN
is: CHEBI:28701
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
boundary condition: false
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110019#_d41db0ff_74ea_4140_abc1_871d9a7c5e77
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:55967
is: F8VQS7
is: SBO:0000252
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110019#_3eb832eb_772e_42ef_9d3e_a36c6921a98d
boundary condition: true
has only substance units: false
is encoded by: hsa:6005
type: Species
initial amount: NaN
name: RHAG
initial concentration: NaN
is: SBO:0000252
is: Q96E98
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_5701e717_f4c3_4e41_9938_19e593b8783a
initial concentration: NaN
is encoded by: hsa:248
type: Species
is: P09923
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ALPI

http://identifiers.org/biomodels.db/MODEL1310110019#_086bf986_be71_4649_aaa9_8bb5bba82209
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: ADH4
initial concentration: NaN
is encoded by: hsa:127
is: P08319
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110019#_181b8f68_a313_4ba2_8a3c_49b5827e2100
is: SBO:0000252
is: Q9UMR5
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9374
name: PPT2
has only substance units: false
boundary condition: true

metaR r0584
modifier: MODEL1310110019#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction

metaM gthrd c
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
name: Reduced glutathione
boundary condition: false
is: C00051
initial concentration: 1.0
is: SBO:0000247
is: HMDB00125
has only substance units: false
constant: false
type: Species

metaR PPA
fast: false
is: SBO:0000176
name: inorganic diphosphatase
reactant: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110019#_907f1833_e59f_4334_9900_a1fa22bc7fb0
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: Q96CD2
initial concentration: NaN
initial amount: NaN
name: PPCDC
is encoded by: hsa:60490
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_63d02fa3_2321_44cd_b8a5_7034a552e845
is: P48728
is: SBO:0000252
name: AMT
initial concentration: NaN
is encoded by: hsa:275
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR r0051
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110019#
is: SBO:0000176
modifier: MODEL1310110019#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110019#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
type: Reaction
reversible: true

metaR DNDPt34m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dTDP antiport
is described by: ECO:0000269
product: MODEL1310110019#
modifier: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110019#
is: SBO:0000185

metaR DASPO1p
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.1
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
name: D-aspartate oxidase, peroxisomal
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: false
product: MODEL1310110019#
is described by: ECO:0000269
modifier: MODEL1310110019#

metaM 4mop c
boundary condition: false
name: 4-methyl-2-oxopentanoate
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00695
constant: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

metaR COt
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is: SBO:0000185
type: Reaction
name: CO transporter via diffusion
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_97ffce49_76e3_47f2_8ad2_a1c6b5b6957f
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: O75438
initial concentration: NaN
boundary condition: true
name: NDUFB1
is encoded by: hsa:4707

metaM fum c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: SBO:0000247
is: CHEBI:29806
name: Fumarate
type: Species
constant: false
is: C00122
is: HMDB00134
initial concentration: 1.0

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM glyb m
name: glycine betaine
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00043
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
type: Species
is: SBO:0000247

metaM ppi m
initial amount: NaN
initial concentration: 1.0
is: C00013
has only substance units: false
is: SBO:0000247
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: HMDB00250
type: Species
is: CHEBI:33019
constant: false

metaR r0504
fast: false
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110019#
reactant: MODEL1310110019#
product: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_3b4eb724_ae6c_4cbe_827b_8b4c9c744b2b
is: SBO:0000252
constant: false
name: ADH1B
initial concentration: NaN
boundary condition: true
is encoded by: hsa:125
is: P00325
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_6678bbc1_0460_4c80_a731_a1c32a39e8bd
name: NME1
type: Species
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR SQLEr
product: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.13.132
fast: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is: SBO:0000176

metaM pheme c
constant: false
initial concentration: 1.0
is: HMDB03178
type: Species
has only substance units: false
is: CHEBI:17627
name: Protoheme
boundary condition: false
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
is: C00032

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR G3PD1
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_7c0cb613_4fc6_4d5b_95ea_2f2c7ded6d6a
is encoded by: hsa:4731
is encoded by: hsa:4712
constant: false
type: Species
initial amount: NaN
has only substance units: false
has part: Q5VYT2
initial concentration: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
is: SBO:0000297

metaM dhor S c
has only substance units: false
is: CHEBI:30864
constant: false
is: HMDB03349
initial amount: NaN
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial concentration: 1.0
name: (S)-dihydroorotate
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_06e069d1_f6d1_42d0_a536_1cc060a3154a
is: P28330
is: SBO:0000252
name: ACADL
has only substance units: false
type: Species
is encoded by: hsa:33
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM 3hpp m
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
is: HMDB00700
initial amount: NaN
is: CHEBI:16510
name: 3-hydroxypropionate

metaR r0718
is version of: http://identifiers.org/ec-code/1.1.1.181
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110019#
reversible: false
kinetic law: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#

metaR CSNATr
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110019#
name: carnitine O-acetyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reversible: true

metaR 4HGLSDm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
reactant: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000212
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_238a4e8d_5f47_444e_bf35_1141b6a94d83
initial concentration: NaN
type: Species
name: _AI378339_1_m
is: SBO:0000252
is encoded by: hsa:AI378339
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r0475
product: MODEL1310110019#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is: SBO:0000176

metaM retn r
boundary condition: false
name: all-trans-retinoate
has only substance units: false
is: HMDB01852
constant: false
is: CHEBI:35291
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN

metaM glu L r
is: CHEBI:29985
boundary condition: false
has only substance units: false
name: L-glutamate(1-)
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: HMDB00148
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110019#_63b5b165_4a68_40d8_b3cc_946d60e47600
is: Q16836
has only substance units: false
constant: false
is encoded by: hsa:3033
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110019#_5fd872b4_6274_4988_8571_9d522f12523f
is: Q13454
name: TUSC3
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:7991
type: Species
has only substance units: false
initial concentration: NaN

metaR NH4tn
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
type: Reaction
name: ammonia nuclear transport
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM thyox L e
name: L-thyroxine
is: SBO:0000247
initial amount: NaN
is: HMDB00248
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: CHEBI:18332

metaR 3MOPt2im
is described by: ECO:0000000
kinetic law: MODEL1310110019#
product: MODEL1310110019#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
reactant: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_feaa0708_eb97_4368_9275_3e9a41394123
boundary condition: true
is: SBO:0000252
is: P15531
is encoded by: hsa:4830
has only substance units: false
constant: false
name: NME1
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_b90f6d32_d2cc_4800_9a16_a3d578dcc3ec
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110019#_6c6aa30a_6ca9_4540_bb92_c26011147967
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: SLC22A2
is encoded by: hsa:6582
type: Species
initial concentration: NaN
is: O15244

http://identifiers.org/biomodels.db/MODEL1310110019#_56d2c067_5215_478c_9428_529cd73f5c69
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: GART
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P22102
is encoded by: hsa:2618

metaM pyr c
is: C00022
name: pyruvate
is: CHEBI:15361
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
is: SBO:0000247
has only substance units: false
is: HMDB00243
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_cb9cda1e_6662_4666_a265_b26fb7376771
initial concentration: NaN
name: PSAT1
boundary condition: true
type: Species
is encoded by: hsa:29968
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r0142
type: Reaction
reactant: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
modifier: MODEL1310110019#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110019#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_830664e3_17a9_4c72_b428_2a3d55637f53
has only substance units: false
constant: false
is: SBO:0000252
is: O43181
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4724
name: NDUFS4
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_be968ea1_7f4f_46da_a17d_a3736a08597d
name: NOS3
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4846
is: A0S0A7
initial amount: NaN

metaM glu L e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
type: Species
constant: false
is: CHEBI:29985
initial concentration: 1.0
initial amount: NaN
name: L-glutamate(1-)

metaR DGNSKm
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
fast: false
product: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000269
name: deoxyguanosine kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_62ec2204_9b9b_4686_9bb6_43c0cacc392f
is encoded by: hsa:4710
type: Species
initial amount: NaN
is: O95168
name: NDUFB4
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_f561a5ae_cd4b_445e_a0f5_77d044691bf2
boundary condition: true
initial amount: NaN
name: SLC23A2
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:9962
constant: false
initial concentration: NaN

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
modifier: MODEL1310110019#
reversible: true
type: Reaction
product: MODEL1310110019#
fast: false
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is version of: http://identifiers.org/ec-code/2.7.8.29
reactant: MODEL1310110019#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110019#

metaM HC02179 e
initial amount: NaN
constant: false
is: SBO:0000247
name: 20-hydroxy-arachidonate
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
boundary condition: false
has only substance units: false

metaM cmpacna c
initial amount: NaN
is: CHEBI:57812
type: Species
boundary condition: false
is: HMDB01176
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
initial concentration: 1.0

metaR ALAtN1
reactant: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
type: Reaction
name: Alanine transport (Na, H coupled)
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR NDPK10
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110019#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110019#
name: nucleoside-diphosphate kinase (ATP:dIDP)
product: MODEL1310110019#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_1af278ee_c8c3_444b_b98d_035b9fea0c4c
initial amount: NaN
has only substance units: false
name: _X63359_1_c
is encoded by: hsa:X63359
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM tym c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: HMDB00306
boundary condition: false
is: CHEBI:327995
constant: false
name: tyraminium
is: SBO:0000247
type: Species
has only substance units: false

metaM nad m
boundary condition: false
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: HMDB00902
is: C00003
is: CHEBI:57540
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_ec776096_3c68_43fb_8b84_9d496744be6e
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:R51273
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _R51273_1_c

metaM mlthf m
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
type: Species
has only substance units: false
is: C00143
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: SBO:0000247
is: HMDB01533
initial amount: NaN

metaM 2mb2coa m
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57337
type: Species
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)

metaR r2519
type: Reaction
product: MODEL1310110019#
name: Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110019#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_c3b48f33_8d20_46ad_a5e5_8bfe0da3c6ba
is encoded by: hsa:8833
name: GMPS
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P49915

metaM co2 c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: CO2
initial concentration: 1.0
constant: false
is: CHEBI:3313
is: C00011
has only substance units: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0

metaM cmp c
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
is: C00055
name: CMP
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:60377

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM pyr e
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00243
name: pyruvate

metaR FALDH
name: formaldehyde dehydrogenase
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
product: MODEL1310110019#
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_7bd237dd_c78b_4d5d_b63c_abad3f446789
is: Q5JWV8
is encoded by: hsa:2182
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: ACSL4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_089e37a1_373a_4de5_9b5e_cfd0a3edccd4
is encoded by: hsa:23305
is: SBO:0000252
constant: false
is: B2RB13
boundary condition: true
name: ACSL6
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR NDPK8n
reactant: MODEL1310110019#
reversible: true
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000176
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
kinetic law: MODEL1310110019#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_aae7f028_eec0_4af5_9fcf_0a6e77ac9e47
is: Q9UGQ3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11182
initial concentration: NaN
name: SLC2A6
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaR PPBNGS
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
name: porphobilinogen synthase
is described by: ECO:0000269
modifier: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.24

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110019#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM dcamp c
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
has only substance units: false
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
boundary condition: false
is: HMDB00536
is: C03794
initial amount: NaN
is: SBO:0000247
is: CHEBI:57567
constant: false
initial concentration: 1.0

metaM malcoa e
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
is: CHEBI:57384
name: malonyl-CoA(4-)
type: Species
initial amount: NaN
is: HMDB01175

metaR PROSTGE2t2
fast: false
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is: SBO:0000185
name: prostaglandin uniport
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
modifier: MODEL1310110019#

metaM HC00342 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR LNSTLSr
is: SBO:0000176
kinetic law: MODEL1310110019#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/5.4.99.7
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
reversible: false
name: lanosterol synthase

http://identifiers.org/biomodels.db/MODEL1310110019#_6a5e584b_6f7a_4043_92d8_8ba0cf57d8fd
constant: false
is encoded by: hsa:50700
is: Q9NYR8
boundary condition: true
is: SBO:0000252
type: Species
name: RDH8
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC02179 c
name: 20-hydroxy-arachidonate
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_5dfbd9fa_961f_4b24_ba0e_c587752962f3
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: _AW299740_1_m
is encoded by: hsa:AW299740
has only substance units: false

metaR MALtm
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110019#
modifier: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
product: MODEL1310110019#
reversible: true
name: malate transport, mitochondrial
kinetic law: MODEL1310110019#

metaR r1847
product: MODEL1310110019#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110019#
reversible: false
modifier: MODEL1310110019#
is: SBO:0000185

metaM HC02213 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28031
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_2bddf05c_b841_41ad_95cf_0724278ebc0a
is encoded by: hsa:6240
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: RRM1
constant: false
is: SBO:0000252
is: P23921
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_10813e92_9ea1_4870_a904_191151f0ac19
constant: false
is: P04062
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2629
has only substance units: false
name: GBA
is: SBO:0000252

metaR PDHm
reactant: MODEL1310110019#
is described by: ECO:0000134
name: pyruvate dehydrogenase
fast: false
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.2.4.1
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_48f6a673_91e5_4279_bd45_0b78127881ac
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1718
is: Q15392
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: DHCR24

http://identifiers.org/biomodels.db/MODEL1310110019#_8126c7cd_ac4b_4584_8e3f_7aba50f69d81
is: P54819
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:204
type: Species
constant: false
name: AK2
has only substance units: false
boundary condition: true
initial amount: NaN

metaR MECOAS1m
kinetic law: MODEL1310110019#
is described by: ECO:0000304
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110019#
modifier: MODEL1310110019#

metaR DOLGLCP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
product: MODEL1310110019#
reversible: false
is described by: ECO:0000000
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
fast: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR UMPK5n
reactant: MODEL1310110019#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP),nuclear
kinetic law: MODEL1310110019#
reversible: true
product: MODEL1310110019#
fast: false
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR GCC2bim
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
modifier: MODEL1310110019#
reactant: MODEL1310110019#

metaM 3hpcoa m
initial amount: NaN
is: CHEBI:58528
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
type: Species

metaM cmp e
is: SBO:0000247
name: CMP(2-)
is: HMDB00095
constant: false
boundary condition: false
is: CHEBI:60377
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
initial amount: NaN
has only substance units: false

metaM co2 e
is: SBO:0000247
constant: false
name: CO2
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
initial concentration: 1.0
is: CHEBI:16526
type: Species
initial amount: NaN
is: HMDB01967
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_e4bfbe25_e340_4306_85f3_3296c7d91be8
has part: Q6IBC4
has part: Q6FG42
has part: E5KNH5
has part: O95299
is encoded by: hsa:4702
has only substance units: false
is encoded by: hsa:4731
has part: F8VQS7
is encoded by: hsa:4536
is encoded by: hsa:126328
is encoded by: hsa:4694
is encoded by: hsa:4697
is encoded by: hsa:4540
has part: C9JT23
boundary condition: true
is encoded by: hsa:4729
is encoded by: hsa:4704
has part: O00483
is encoded by: hsa:7991
has part: Q549M5
is encoded by: hsa:4539
has part: P19404
is encoded by: hsa:4706
is encoded by: hsa:4719
is encoded by: hsa:4726
is encoded by: hsa:4711
has part: P03915
has part: O95169
has part: O75489
has part: O43678
initial amount: NaN
is encoded by: hsa:4709
is encoded by: hsa:4713
is encoded by: hsa:4701
has part: O95139
is encoded by: hsa:51079
is encoded by: hsa:4695
has part: P03897
has part: O00217
is: SBO:0000297
has part: O43181
is encoded by: hsa:4715
has part: Q13454
is encoded by: hsa:4722
has part: O43677
has part: Q6IBB5
is encoded by: hsa:4537
has part: O95167
has part: Q6IBA0
is encoded by: hsa:374291
has part: P28331
is encoded by: hsa:4717
has part: O43674
is encoded by: hsa:4705
has part: Q9Y6M9
has part: Q16795
is encoded by: hsa:4724
is encoded by: hsa:4698
is encoded by: hsa:4712
type: Species
constant: false
has part: P56181
has part: Q9P0J0
is encoded by: hsa:4707
has part: O95168
is encoded by: hsa:4714
has part: Q7GXZ1
has part: O14561
is encoded by: hsa:4728
is encoded by: hsa:4716
has part: P56556
has part: H7C5B8
has part: B7Z792
is encoded by: hsa:4720
has part: Q85KV6
is encoded by: hsa:4538
is encoded by: hsa:4535
has part: Q7GXY9
has part: P03905
is encoded by: hsa:4696

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:30623
is: HMDB02329
initial amount: NaN
constant: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
has only substance units: false
is: SBO:0000247

metaM itp e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
is: CHEBI:57614
initial amount: NaN
type: Species
constant: false
is: HMDB00189

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_d3fdef59_e58b_4d19_9030_c5f130a1af85
constant: false
is: SBO:0000252
is encoded by: hsa:4723
initial amount: NaN
boundary condition: true
is: E5KNH5
has only substance units: false
name: NDUFV1
initial concentration: NaN
type: Species

metaR GTHOm
reversible: false
name: glutathione oxidoreductase
modifier: MODEL1310110019#
fast: false
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254

metaR RE1531M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110019#
name: RE1531
modifier: MODEL1310110019#
fast: false
reversible: true
kinetic law: MODEL1310110019#
type: Reaction
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_ac4ea879_c833_49f0_8102_909aa44a5a6e
initial concentration: NaN
is: P22392
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: NME2
is: SBO:0000252
type: Species
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110019#_a03cfa92_2ca3_4fda_8c28_d6fd21290a5f
boundary condition: true
initial amount: NaN
is: Q9BY49
initial concentration: NaN
is encoded by: hsa:55825
name: PECR
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaM 3pg c
constant: false
type: Species
is: HMDB00807
initial concentration: 1.0
is: CHEBI:58272
has only substance units: false
name: 3-Phospho-D-glycerate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
initial amount: NaN
is: SBO:0000247
is: C00197

metaR PIt8
reversible: true
is described by: ECO:0000006
is: SBO:0000185
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter
modifier: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_acc84740_0507_4b89_baf8_f07a3ccf0b14
constant: false
initial amount: NaN
initial concentration: NaN
is: B7Z792
is encoded by: hsa:4720
has only substance units: false
name: NDUFS2
type: Species
is: SBO:0000252
boundary condition: true

metaM anth c
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial concentration: 1.0
is: SBO:0000247
is: HMDB01123
name: anthranilate
type: Species
initial amount: NaN
is: CHEBI:16567
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_96943372_ac12_4a6b_a6f1_43ca26f37d81
is encoded by: hsa:2821
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: GPI
boundary condition: true
is: P06744

metaR r0724
type: Reaction
modifier: MODEL1310110019#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
kinetic law: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_f4c2cf04_9084_4fd3_8dc6_29f5876177ae
is: SBO:0000252
constant: false
initial amount: NaN
is: Q13232
is encoded by: hsa:4832
has only substance units: false
initial concentration: NaN
name: NME3
boundary condition: true
type: Species

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110019#

metaR DURItn
name: deoxyuridine transport in nucleus
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR RE0344C
reversible: true
modifier: MODEL1310110019#
is: SBO:0000176
name: RE0344
fast: false
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110019#
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110019#_b5521a84_486b_410e_9a3e_9c42a9191a0a
is: SBO:0000252
type: Species
is: Q96PE3
initial amount: NaN
name: INPP4A
initial concentration: NaN
is encoded by: hsa:3631
boundary condition: true
constant: false
has only substance units: false

metaR DM anth
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR LTC4Sr
reversible: false
is: SBO:0000176
name: Leukotriene C4 synthase
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.4.1.20
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110019#

metaR INSTt2r
product: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
reversible: true
name: inositol transport in via proton symport
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_155e8699_fe3e_49d4_8ae9_e05a127248f1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PIK3C2G
is: O75747
constant: false
has only substance units: false
is encoded by: hsa:5288

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_b999867d_6e98_451c_9e86_86a16682b6a2
initial concentration: NaN
name: SLC16A8
type: Species
is encoded by: hsa:23539
is: O95907
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_0511edb7_3407_45ce_90b3_0e6a65b603ca
type: Species
initial amount: NaN
name: ACOT6
is: Q3I5F7
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:641372
has only substance units: false
initial concentration: NaN

metaM mi3p D c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
initial concentration: 1.0
is: HMDB06814
name: 1D-myo-inositol 3-phosphate(2-)
constant: false
initial amount: NaN
is: CHEBI:58401
boundary condition: false
type: Species

metaM udpglcur c
is: C00167
initial amount: NaN
boundary condition: false
is: HMDB00935
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: UDP-D-glucuronate
is: CHEBI:58052
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaM asp D x
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
constant: false
is: SBO:0000247
is: CHEBI:29990
type: Species
is: HMDB06483
has only substance units: false
name: D-aspartate(1-)
initial concentration: 1.0

metaM itp c
initial concentration: 1.0
is: CHEBI:57614
is: HMDB00189
type: Species
constant: false
boundary condition: false
name: ITP(3-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaM glyc R m
type: Species
is: CHEBI:16659
name: D-glycerate
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00139
has only substance units: false
constant: false

metaR XOLEST2te
type: Reaction
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
name: cholesterol ester transporter
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:

metaM lnlccrn m
name: Linoleyl carnitine
has only substance units: false
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
initial concentration: 1.0
is: HMDB06469
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_27327849_f56c_44fb_b370_fae05aa8354a
initial concentration: NaN
name: SLC38A1
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9H2H9
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:81539

metaM dudp c
is: C01346
is: HMDB01000
is: CHEBI:60471
name: dUDP
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
type: Species
constant: false

metaR DURIt
type: Reaction
product: MODEL1310110019#
fast: false
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyuridine transport via diffusion
is described by: ECO:0000000

metaR FADtru
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
type: Reaction
name: FAD transporter, endoplasmic reticulum
reversible: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR RE3004M
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3004
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110019#_3681449a_9716_4875_a541_adbca2881bb8
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CYP27A1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1593
is: Q02318

metaR RTOTAL2t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110019#
name: RTOTAL2 transport
is: SBO:0000185
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9c9466b1_a89d_492a_8877_9fec2c258874
is: P30084
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1892
is: SBO:0000252
has only substance units: false
name: ECHS1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_45860479_6c88_4629_b8cc_f0b0973cb0e7
constant: false
type: Species
name: AFMID
is: Q63HM1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:125061
boundary condition: true

metaR ITCOALm
modifier: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000176
fast: false
is described by: ECO:0000212
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction

metaR r1423
product: MODEL1310110019#
fast: false
name: Facilitated diffusion
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110019#
type: Reaction
reactant: MODEL1310110019#
is described by: ECO:0000000

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r0722
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
fast: false
reversible: true
product: MODEL1310110019#
is: SBO:0000176
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.3.12
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM anth e
is: SBO:0000247
is: HMDB01123
initial concentration: 1.0
initial amount: NaN
type: Species
name: anthranilate
is: CHEBI:16567
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

metaR PRODt2r
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is described by: ECO:0000304
product: MODEL1310110019#
fast: false
name: D-proline reversible transport via proton symport
reactant: MODEL1310110019#
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_2c57a86b_2594_475c_8c34_380f938d349f
boundary condition: true
is: O00483
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFA4
is encoded by: hsa:4697
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_bab9cc5f_8112_4c24_980c_506edc1b6338
is encoded by: hsa:4706
is: O14561
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFAB1
initial concentration: NaN

metaM CE2705 c
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
name: quinonoid dihydrobiopterin
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:52328

metaR CYTK11n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
modifier: MODEL1310110019#
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaM mlthf c
boundary condition: false
is: C00143
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01533
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
constant: false

metaM mthgxl c
boundary condition: false
constant: false
initial concentration: 1.0
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
is: HMDB01167
is: CHEBI:17158
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_be3eabd2_12d2_42cd_ae22_cd7cbb495325
is: SBO:0000252
is encoded by: hsa:6515
type: Species
initial amount: NaN
is: P11169
boundary condition: true
constant: false
initial concentration: NaN
name: SLC2A3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_e8c080fe_dd3b_4a39_93af_cefcf8214cca
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ALDH1A3
is: SBO:0000252
is: P47895
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:220

metaR r0149
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110019#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_19a9ae1e_f8dc_4174_9f2d_53a0ed2243c2
initial concentration: NaN
has only substance units: false
name: _AI285872_1_c
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI285872
constant: false
initial amount: NaN

metaM HC00342 c
is: SBO:0000247
constant: false
is: CHEBI:16383
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
initial concentration: 1.0
name: cis-aconitate(3-)

http://identifiers.org/biomodels.db/MODEL1310110019#_61d6a951_729e_4e1f_b577_5967d53d887f
initial amount: NaN
type: Species
is encoded by: hsa:3939
boundary condition: true
is: P00338
has only substance units: false
constant: false
is: SBO:0000252
name: LDHA
initial concentration: NaN

metaR LPS2e
kinetic law: MODEL1310110019#
type: Reaction
name: lipase, extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
fast: false
modifier: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM thr L e
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
is: HMDB00167
initial concentration: 1.0
constant: false
is: CHEBI:16857

metaR r0720
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110019#
kinetic law: MODEL1310110019#
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_4cd27ea2_a775_4734_85d8_7cb472956e18
type: Species
name: ALPP
initial concentration: NaN
initial amount: NaN
constant: false
is: P05187
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:250

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110019#
type: Reaction
is described by: ECO:0000134
fast: false
is: SBO:0000185
reversible: true
name: Transport of anthranilate
product: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR RE3218C
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
name: RE3218
product: MODEL1310110019#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2

metaM ahcys r
is: HMDB00939
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16680
name: S-adenosyl-L-homocysteine
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaR FATP3t
kinetic law: MODEL1310110019#
is: SBO:0000185
fast: false
modifier: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000269
name: fatty acid electroneutral transport
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110019#_209e3860_283d_472a_9c42_96e1953c44ad
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: _AL038231_1_c
has only substance units: false
is encoded by: hsa:AL038231

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_b991cdf8_8b38_439d_9dd6_bf3b374cd946
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:J03866
name: _J03866_1_m
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_53f19bf4_2f58_46e4_ba76_0d40c3f6bc6d
is encoded by: hsa:23057
constant: false
name: NMNAT2
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110019#_5e96a95b_2961_4a63_b1af_97b64f5f14df
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:3098
is: P78542
type: Species
boundary condition: true
name: HK1

metaM ser D e
name: D-serine
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16523
has only substance units: false
is: HMDB03406
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false

metaR RE0512M
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
fast: false
name: RE0512
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110019#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110019#
is: SBO:0000176

metaR RE2147C
notes: GENE_ASSOCIATION: (54658.1) SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10702251 NOTES:
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000176
product: MODEL1310110019#
is described by: ECO:0000000
type: Reaction
name: RE2147
is version of: http://identifiers.org/ec-code/2.4.1.17
reactant: MODEL1310110019#
modifier: MODEL1310110019#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110019#_4d5830c3_65a6_438d_9c42_c421b7dcdd35
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC24A2
is encoded by: hsa:25769
boundary condition: true
is: Q9UI40
is: SBO:0000252
has only substance units: false

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
product: MODEL1310110019#
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110019#
reversible: true
reactant: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110019#

metaR r0830
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
reactant: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM mthgxl e
is: HMDB01167
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17158
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_9d622393_014b_47e1_a8e5_a7b68fb106cc
is: P00709
initial concentration: NaN
is encoded by: hsa:3906
constant: false
name: LALBA
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_200f47ac_5e38_4785_9632_f46ff8e35376
initial concentration: NaN
initial amount: NaN
is: D9HTE9
has only substance units: false
type: Species
name: SLC25A1
is encoded by: hsa:6576
boundary condition: true
constant: false
is: SBO:0000252

metaR 3MOPte
kinetic law: MODEL1310110019#
name: Transport of 3-methyl-2-oxopentanoate
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110019#
fast: false

metaM acac x
name: acetoacetate
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
is: HMDB00060
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:13705
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_1ee3a04f_7a88_489f_ae06_58540ae3ced0
boundary condition: true
type: Species
has only substance units: false
is: P15291
initial concentration: NaN
initial amount: NaN
constant: false
name: B4GALT1
is encoded by: hsa:2683
is: SBO:0000252

metaR RE1520M
reactant: MODEL1310110019#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110019#
reversible: true
fast: false
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110019#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110019#_65b0b27c_fea0_4414_a9e0_cb4ecaba62d1
is: Q8IWX5
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: SGPP2
is: SBO:0000252
is encoded by: hsa:130367
constant: false
initial concentration: NaN

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM HC02187 e
has only substance units: false
name: reverse-triiodthyronine
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_6e5ec245_1bb2_4599_8bef_954ad63782a8
is: SBO:0000252
is: Q15392
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DHCR24
is encoded by: hsa:1718
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7e798c52_aba1_48f5_90be_eef1e479b2a0
initial amount: NaN
name: HSD17B4
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3295
is: SBO:0000252
is: E9PB82

http://identifiers.org/biomodels.db/MODEL1310110019#_bd5dc0c6_b10e_4b14_af9d_9fe478239915
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449
is: P42765
constant: false
name: ACAA2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_a62c6462_cd0a_4231_803b_fc4202adc5cd
is: SBO:0000252
is: P17516
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1109
type: Species
name: AKR1C4

metaM CE4876 r
is: SBO:0000247
constant: false
is: CHEBI:57923
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
initial amount: NaN
has only substance units: false
boundary condition: false

metaM 5dhf e
boundary condition: false
has only substance units: false
is: HMDB06487
name: pentaglutamyl folate (DHF)
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
is: SBO:0000247

metaM CE5788 e
type: Species
is: CHEBI:27485
initial concentration: 1.0
boundary condition: false
is: HMDB02710
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
constant: false
has only substance units: false
is: SBO:0000247
name: kinetensin 1-7
initial amount: NaN

metaR RE1516M
reactant: MODEL1310110019#
name: RE1516
modifier: MODEL1310110019#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
kinetic law: MODEL1310110019#
is described by: ECO:0000000
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110019#_e913d954_55d7_485c_af91_f4c0f1de014c
is: O00217
constant: false
initial amount: NaN
is encoded by: hsa:4728
has only substance units: false
name: NDUFS8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15361
is: C00022
is: HMDB00243
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110019#_a2b83109_e042_49f8_85a0_6bc08222268d
is: Q1EHB4
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:159963
boundary condition: true
initial amount: NaN
name: SLC5A12
is: SBO:0000252

metaR ACALDt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: acetaldehyde reversible transport
fast: false
reactant: MODEL1310110019#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110019#
product: MODEL1310110019#

metaR LDH D
is: SBO:0000176
reversible: true
name: D-lactate dehydrogenase
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
product: MODEL1310110019#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_443afb76_ea35_4816_a739_7cfcf03b8fa1
is: SBO:0000252
name: MSMO1
is encoded by: hsa:6307
is: A8MYF6
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_9d89d487_09e8_4599_a807_8ef3a99aa5ef
is encoded by: hsa:9162
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: DGKI
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O75912

http://identifiers.org/biomodels.db/MODEL1310110019#_17e9c3ad_354a_4fe6_9336_f795ab6b4434
name: FDPS
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2224
is: P14324
type: Species
boundary condition: true

metaM aicar c
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C04677
has only substance units: false
constant: false
is: CHEBI:58475
is: HMDB01517

http://identifiers.org/biomodels.db/MODEL1310110019#_b5ddc268_2aab_4f37_be1d_64f4afbb8bd1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: AK5
is encoded by: hsa:26289
boundary condition: true

metaR FTHFLm
reversible: true
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
type: Reaction
fast: false
product: MODEL1310110019#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
modifier: MODEL1310110019#
is version of: http://identifiers.org/ec-code/6.3.4.3
name: formate-tetrahydrofolate ligase, mitochondrial
is: SBO:0000176

metaR PROSTGD2t
product: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
reactant: MODEL1310110019#

http://identifiers.org/biomodels.db/MODEL1310110019#_4c19d82c_13ca_41f1_8fd6_b56993d548fe
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ALDH3A2
constant: false
is: P51648
is: SBO:0000252
is encoded by: hsa:224

metaR DHCR241r
reactant: MODEL1310110019#
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110019#
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: 24-dehydrocholesterol reductase [Precursor]
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is version of: http://identifiers.org/ec-code/1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110019#_c8f89e55_9be1_42ef_87c7_a0d41eb46b0b
initial concentration: NaN
initial amount: NaN
name: HADH
is: SBO:0000252
is: Q16836
boundary condition: true
type: Species
is encoded by: hsa:3033
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_1e29fe1c_ff10_4427_9f1f_363c74b3c719
initial concentration: NaN
has part: P00326
is: SBO:0000297
constant: false
has only substance units: false
type: Species
is encoded by: hsa:126
name: ADH1A:ADH1C
boundary condition: true
initial amount: NaN

metaM glyclt c
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: glycolate
is: SBO:0000247
is: CHEBI:29805
constant: false

metaM hdd2coa m
is: SBO:0000247
constant: false
is: C05272
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
is: CHEBI:61526
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
type: Species
initial amount: NaN
boundary condition: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM HC01403 m
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM HC01397 m
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
initial concentration: 1.0
has only substance units: false
type: Species

metaR RE0569E
reversible: false
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0569
is: SBO:0000176
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110019#
product: MODEL1310110019#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_49378d5b_31d0_49d2_b01b_619cd671aab6
name: SLC5A11
is: Q8WWX8
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:115584
is: SBO:0000252

metaR r2037
kinetic law: MODEL1310110019#
product: MODEL1310110019#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110019#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110019#_0c39a889_9347_4243_87bd_6db8d8664c60
is encoded by: hsa:3706
constant: false
initial concentration: NaN
name: ITPKA
has only substance units: false
boundary condition: true
is: P23677
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_d5442f53_105d_4bf6_a1cb_c3ddde7873b4
has only substance units: false
constant: false
name: SLC9A5
is: Q9NSW9
initial concentration: NaN
is encoded by: hsa:6553
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaM dmnoncrn m
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
has only substance units: false
is: HMDB06202
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110019#_cc0ea5cd_9e0d_45c4_82f7_6783cac71080
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:7296
name: TXNRD1
is: SBO:0000252
initial concentration: NaN
type: Species

metaR CTPtn
name: CTP diffusion in nucleus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110019#
reversible: true
is: SBO:0000185
product: MODEL1310110019#
kinetic law: MODEL1310110019#
type: Reaction
is described by: ECO:0000000

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM HC02187 c
name: reverse-triiodthyronine
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
type: Species
boundary condition: false
is: CHEBI:28774
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR FAOXC180x
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110019#
type: Reaction
kinetic law: MODEL1310110019#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110019#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM oxa m
name: oxalate(2-)
initial amount: NaN
constant: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02329
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110019#_e084fb35_ba2c_4c69_bd32_ea8c537f56b7
constant: false
initial concentration: NaN
is: P10746
is: SBO:0000252
has only substance units: false
name: UROS
type: Species
is encoded by: hsa:7390
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_5e2425ba_193b_41fd_9772_5bc80322f6e6
constant: false
initial concentration: NaN
is encoded by: hsa:50814
is: Q15738
boundary condition: true
initial amount: NaN
has only substance units: false
name: NSDHL
is: SBO:0000252
type: Species

metaR RE1527M
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110019#
product: MODEL1310110019#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110019#
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
fast: false

metaR GLYCTDle
is described by: ECO:0000134
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM adn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16335
initial concentration: 1.0
is: HMDB00050
is: C00212
boundary condition: false
name: Adenosine
initial amount: NaN
has only substance units: false

metaM retinol e
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:50211
name: retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
constant: false
initial concentration: 1.0

metaR 7DHCHSTEROLtr
kinetic law: MODEL1310110019#
is described by: ECO:0000000
name: cholesterol precursor intracellular transport
type: Reaction
fast: false
product: MODEL1310110019#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
reactant: MODEL1310110019#

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is described by: ECO:0000000
kinetic law: MODEL1310110019#
type: Reaction

metaM 3pg m
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
constant: false
is: SBO:0000247
type: Species
is: HMDB00807
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58272

metaR FACOAL204
reactant: MODEL1310110019#
is described by: ECO:0000269
kinetic law: MODEL1310110019#
reversible: true
product: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
name: fatty-acid--CoA ligase

metaM pppg9 c
initial concentration: 1.0
is: HMDB01097
is: C01079
boundary condition: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
type: Species
is: CHEBI:57307
constant: false
has only substance units: false
is: SBO:0000247
name: Protoporphyrinogen IX
initial amount: NaN

metaR BILIRED
is version of: http://identifiers.org/ec-code/1.3.1.24
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
product: MODEL1310110019#
is: SBO:0000176
name: Nad(p)h biliverdin reductase
is described by: ECO:0000000
reactant: MODEL1310110019#
reversible: false
type: Reaction
fast: false

metaM stcoa c
initial concentration: 1.0
boundary condition: false
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57394
initial amount: NaN
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
type: Species

metaR KHK
name: ketohexokinase
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110019#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3
product: MODEL1310110019#
is: SBO:0000176
kinetic law: MODEL1310110019#
modifier: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR DRPA
reactant: MODEL1310110019#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110019#
kinetic law: MODEL1310110019#
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
reversible: false
fast: false

metaM gmp c
initial amount: NaN
is: C00144
name: GMP
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115

metaR MI4PP
reversible: false
modifier: MODEL1310110019#
name: myo-inositol 4-phosphatase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110019#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110019#

metaM cmpacna n
initial concentration: 1.0
boundary condition: false
is: HMDB01176
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
constant: false
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110019#_e7e2e83c_ddec_4585_b05c_44ee780bfa31
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:221
is: SBO:0000252
is: P43353
name: ALDH3B1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_494fecf9_d5c7_466d_8090_23a0ae775096
initial amount: NaN
name: NDUFA13
is: Q9P0J0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51079
constant: false
type: Species

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
name: R total Coenzyme A
is: HMDB00904
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16349
boundary condition: false
constant: false

metaR MAN6PI
modifier: MODEL1310110019#
name: mannose-6-phosphate isomerase
is described by: ECO:0000304
type: Reaction
product: MODEL1310110019#
reactant: MODEL1310110019#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.8
kinetic law: MODEL1310110019#

metaR r2309
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is described by: ECO:0000000
product: MODEL1310110019#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110019#
reactant: MODEL1310110019#
reversible: true
type: Reaction
is: SBO:0000185

metaR CYSASNNaEx
kinetic law: MODEL1310110019#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
type: Reaction
is: SBO:0000185
fast: false
reversible: false
modifier: MODEL1310110019#
is described by: ECO:0000269
product: MODEL1310110019#
reactant: MODEL1310110019#

metaM 5thf e
type: Species
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB06487
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_4697976b_86b8_4f41_81eb_f0c65916b76f
type: Species
has only substance units: false
name: UGT1A1
boundary condition: true
constant: false
is: P22309
is: SBO:0000252
is encoded by: hsa:54658
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110019#_c65c1894_463e_41aa_b7e9_181d1c9d0167
boundary condition: true
is: SBO:0000252
is encoded by: hsa:219
name: ALDH1B1
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110019#_4eb12912_09e7_4e5a_9989_d475c5c437fd
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:55350
type: Species
name: VNN3
boundary condition: true
initial concentration: NaN

metaR r0835
reactant: MODEL1310110019#
reversible: true
product: MODEL1310110019#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110019#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110019#
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM zymst r
is: HMDB06271
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: zymosterol
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
type: Species
is: CHEBI:18252
constant: false

metaM thr L c
boundary condition: false
has only substance units: false
is: CHEBI:16857
is: SBO:0000247
initial concentration: 1.0
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
is: HMDB00167
type: Species
constant: false

metaM glu L c
initial concentration: 1.0
is: SBO:0000247
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
initial amount: NaN
is: CHEBI:29985
is: HMDB00148
boundary condition: false
type: Species
constant: false

metaM nad r
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00902
name: NAD(1-)
type: Species
is: CHEBI:57540
constant: false
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

http://identifiers.org/biomodels.db/MODEL1310110019#_ead96f72_7a36_40d9_8fa0_27509f8a09b9
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CA8
constant: false
type: Species
is encoded by: hsa:767
initial concentration: NaN
is: P35219
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110019#_b90132b6_e787_4e49_abcf_ebb0d9b2a9c8
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
initial concentration: NaN

metaR CYTK1n
product: MODEL1310110019#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110019#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110019#
kinetic law: MODEL1310110019#

metaR GLYSNAT5tc
kinetic law: MODEL1310110019#
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CMPACNAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110019#
fast: false
is: SBO:0000185
product: MODEL1310110019#
reactant: MODEL1310110019#
is described by: ECO:0000000
reversible: false
name: CMP-Sia nuclear export
type: Reaction

metaR CGLYt3 2
is described by: ECO:0000304
type: Reaction
reversible: false
reactant: MODEL1310110019#
name: Cys-Gly transport in via proton symport
fast: false
modifier: MODEL1310110019#
is: SBO:0000185
kinetic law: MODEL1310110019#
product: MODEL1310110019#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaM retinol c
boundary condition: false
is: SBO:0000247
name: retinol
type: Species
initial amount: NaN
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
has only substance units: false
is: HMDB00305
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_7accc47d_666e_45f5_a946_bc6b3b789d36
type: Species
name: SLC7A8:SLC3A2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:23428
has part: Q86U05
constant: false

http://identifiers.org/biomodels.db/MODEL1310110019#_3ea5b973_a680_4b18_9e2e_df04e8d53eff
initial concentration: NaN
is encoded by: hsa:8867
name: SYNJ1
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: C9JFZ1
boundary condition: true
initial amount: NaN

metaM mescon m
initial amount: NaN
is: HMDB00749
is: CHEBI:36986
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaM retn c
is: HMDB01852
name: all-trans-retinoate
initial concentration: 1.0
is: CHEBI:35291
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110019#_d9669cb5_6ce4_483e_ac9f_5fd4794d6457
is: P21953
boundary condition: true
initial concentration: NaN
name: BCKDHB
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:594