http://identifiers.org/biomodels.db/MODEL1310110018#_86d11812_4206_4cee_9812_fa32763d9af4
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC12A7
is: Q9Y666
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10723
boundary condition: true

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR G14T17g
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110018#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110018#

metaM ca2 e
is: SBO:0000247
constant: false
is: CHEBI:29108
type: Species
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
boundary condition: false
name: calcium(2+)
has only substance units: false
initial concentration: 1.0

metaR PRGSTRNt
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110018#
is: SBO:0000185
name: Progesterone transport
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_aa4ca359_c92d_4597_9022_5b9a5019d55e
is: O95299
name: NDUFA10
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4705
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_9bbb756b_2d1f_4e59_93f8_c532d35257c2
initial amount: NaN
name: ALPPL2
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:251
type: Species
is: P10696

http://identifiers.org/biomodels.db/MODEL1310110018#_1e410344_744b_4709_90b8_ed288cf49f1f
has part: P22392
has part: P15531
constant: false
name: NME1:NME2
is encoded by: hsa:4831
is encoded by: hsa:4830
boundary condition: true
has only substance units: false
is: SBO:0000297
initial amount: NaN
type: Species
initial concentration: NaN

metaR RE1534M
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is: SBO:0000176
name: RE1534
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_d8cf7eb4_876d_4f53_8e09_6e4ac578fec9
constant: false
initial amount: NaN
name: TM7SF2
is encoded by: hsa:7108
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: O76062
is: SBO:0000252

metaR r1580
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110018#_309f0629_9175_48bc_a91b_c3c3fab690ff
name: _C7orf24_1_m
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:C7orf24
boundary condition: true
has only substance units: false
constant: false

metaM CE4790 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57923
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA

metaR FAOXC165C164m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_12a6180a_586e_4b89_87d4_e164fda8e064
initial concentration: NaN
is encoded by: hsa:8659
is: SBO:0000252
has only substance units: false
type: Species
is: P30038
constant: false
boundary condition: true
initial amount: NaN
name: ALDH4A1

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM urea m
is: CHEBI:16199
constant: false
name: Urea
is: C00086
type: Species
is: HMDB00294
boundary condition: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR SERGLYexR
fast: false
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#

metaR PPPG9tm
fast: false
reactant: MODEL1310110018#
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
kinetic law: MODEL1310110018#
reversible: true
name: protoporphyrinogen IX mitochondrial transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_8bcf77c9_6742_4edf_bd9b_20bd95fe5640
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4645
constant: false
name: MYO5B
type: Species
is: Q9H6Y6

metaR GCALDD
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110018#
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaM c14dccoa x
is: HMDB02288
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: tetradecanedioylcoa
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_e6a3ebba_fc3f_4e86_bb7d_2f1a5c56cd82
is encoded by: hsa:3028
constant: false
initial amount: NaN
type: Species
name: HSD17B10
boundary condition: true
is: Q99714
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r1429
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110018#
fast: false
name: Free diffusion
product: MODEL1310110018#
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_7f87129d_c71a_4f8a_9ca2_8e02781aca4f
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: P53597
is: SBO:0000252
has only substance units: false
name: SUCLG1
is encoded by: hsa:8802

metaR SERGLNNaEx
kinetic law: MODEL1310110018#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d08978e8_ecc3_4f0b_ac44_74d485b1fb16
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:U52111
type: Species
name: _U52111_1_c
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_42c13030_31fe_4d02_a6e6_331dddb4eea0
boundary condition: true
type: Species
constant: false
is encoded by: hsa:BG035985
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _BG035985_1_c
initial amount: NaN

metaR UGLT
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110018#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
modifier: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000

metaM 3mop e
has only substance units: false
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:28654
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR DNDPt14m
name: dUDP transport via dTDP antiport
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction

metaR RE3000M
reversible: true
reactant: MODEL1310110018#
name: RE3000
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110018#

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: CHEBI:58439
type: Species
initial amount: NaN
name: UDP-D-galactose(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00302
boundary condition: false
has only substance units: false

metaM fuc L l
type: Species
is: SBO:0000247
name: L-fucose
is: HMDB00174
is: CHEBI:18287
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
initial concentration: 1.0

metaR PIACGT
reversible: false
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.83
is version of: http://identifiers.org/ec-code/2.4.1.198
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
name: phosphatidylinositol N-acetylglucosaminyltransferase

metaR FACOAL180i
fast: false
is described by: ECO:0000269
name: C180 fatty acid activation
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
type: Reaction

metaM btamp c
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Biotinyl-5'-AMP
is: CHEBI:3110
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_99848e85_5699_44b5_b6ae_857f69669ee9
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5337
is: Q59EA4
has only substance units: false
type: Species
is: SBO:0000252
name: PLD1

http://identifiers.org/biomodels.db/MODEL1310110018#_da6bfa57_10b7_4256_80eb_b0f4c6e90275
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9Y619
is encoded by: hsa:10166
constant: false
name: SLC25A15
has only substance units: false

metaR FAS100COA
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty acyl-CoA synthase (n-C10:0CoA)
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110018#_6bd652ba_2a71_4b79_9899_d2228a01aa05
is: Q13946
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PDE7A
constant: false
is encoded by: hsa:5150
has only substance units: false
type: Species

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM core6 l
type: Species
has only substance units: false
is: CHEBI:12936
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
is: HMDB00143

metaM ksi pre23 g
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28067
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species

metaR NMNATr
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110018#
reversible: true
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110018#

metaR LGTHL
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000269
name: lactoylglutathione lyase
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.5

metaR r1428
is described by: ECO:0000000
name: Free diffusion
type: Reaction
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false

metaR AG13T1g
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110018#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_63f517dd_45ad_4d0d_95ef_048f7c4fd5cf
is: Q5K4L6
type: Species
is encoded by: hsa:11000
name: SLC27A3
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR PGLer
product: MODEL1310110018#
reversible: false
type: Reaction
name: 6-phosphogluconolactonase, endoplasmic reticulum
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110018#
is: SBO:0000176

metaM zymst r
is: HMDB06271
is: CHEBI:18252
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
name: zymosterol
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437

metaM retinal cis 13 r
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB06220
name: 13-cis-retinal
type: Species
is: SBO:0000247
is: CHEBI:45487
initial concentration: 1.0

metaM crvnc e
is: HMDB02183
is: SBO:0000247
is: CHEBI:36005
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C22H31O2 CHARGE: -1
constant: false
name: cervonic acid, C22:6 n-3
initial amount: NaN
has only substance units: false

metaM 3mop c
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00491
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
initial amount: NaN

metaM hdcoa c
constant: false
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: HMDB06532

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110018#
is described by: ECO:0000134
type: Reaction
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.12
product: MODEL1310110018#
fast: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r1252
name: EC:6.2.1.3
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
reactant: MODEL1310110018#
reversible: false
type: Reaction
product: MODEL1310110018#

metaR NDPK7n
modifier: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110018#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
type: Reaction
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176

metaR DOLPMT3 Uer
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110018#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM rnam c
initial amount: NaN
has only substance units: false
is: HMDB00855
name: N-Ribosylnicotinamide
is: CHEBI:15927
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_1b942d9c_3814_4dc0_a8d8_b052648fb94b
constant: false
is: B2RD24
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:25902
name: MTHFD1L

http://identifiers.org/biomodels.db/MODEL1310110018#_7c640b2b_9bfd_4659_83e4_cb4701ecf4a0
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: PDE5A
is encoded by: hsa:8654
is: O76074
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_ceb3c727_8bbb_41ed_afda_0ace5311dd16
is encoded by: hsa:4199
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: ME1
is: P48163

http://identifiers.org/biomodels.db/MODEL1310110018#_0cdf02d0_9dc9_4087_8f41_6eb26e9cc619
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q75T13
is encoded by: hsa:80055
name: PGAP1

metaR P4503A5
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.14.1
notes: GENE_ASSOCIATION: (1577.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES:_8,9 epoxidation of aflatoxin assumed to take place on outer membrane NJ
modifier: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110018#
name: cytochrome P450 3A5

http://identifiers.org/biomodels.db/MODEL1310110018#_dbf7d216_efdd_4f23_8f09_a9b6bf3c8081
boundary condition: true
initial concentration: NaN
type: Species
name: IVD
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3712
is: B3KVI7
has only substance units: false

metaR H2Otly
is: SBO:0000185
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: H2O transport, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM 5adtststerone r
is: CHEBI:16330
type: Species
initial amount: NaN
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false

metaR SERALANaEx
product: MODEL1310110018#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_2455a98f_7daf_445a_88d7_7b2787d4a554
is: SBO:0000297
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: O95498
boundary condition: true
type: Species
name: VNN3:VNN2:VNN1

metaM crn x
name: L-Carnitine
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: HMDB00062
is: SBO:0000247
constant: false
has only substance units: false
is: C00318
type: Species
initial concentration: 1.0
initial amount: NaN

metaR GMAND
name: GDP-D-mannose dehydratase
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.47
fast: false
product: MODEL1310110018#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR GLCNACASE4ly
modifier: MODEL1310110018#
reversible: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110018#

metaM so4 l
is: HMDB01448
name: sulfate
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
type: Species
initial concentration: 1.0

metaM trdox c
is: SBO:0000247
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:18191
has only substance units: false
is: C00343
initial concentration: 1.0
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110018#_c8a9b507_d4f4_4ec7_8ca0_1cb2562dc207
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2585
constant: false
name: GALK2
boundary condition: true
has only substance units: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM udpgal g
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: CHEBI:58439
type: Species
boundary condition: false
constant: false
has only substance units: false
is: HMDB00302
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_ebd0a074_9815_47f0_a2d4_bfc9b956b5e9
is encoded by: hsa:3098
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P19367
is: SBO:0000252
constant: false
type: Species
name: HK1
has only substance units: false

metaM crvnc c
initial concentration: 1.0
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
has only substance units: false
is: CHEBI:36005
constant: false
name: cervonic acid, C22:6 n-3
is: SBO:0000247
is: HMDB02183
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_81df7356_d562_4166_968c_94148e2b0ec2
initial amount: NaN
constant: false
is: Q9NS00
type: Species
is: SBO:0000252
name: C1GALT1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56913

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_81b19631_39e6_4f65_af23_083872e7119b
name: PDE9A
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5152
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_2f8df7e9_6941_44dc_9d26_f9572880d71f
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O95497
initial concentration: NaN
name: VNN1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:8876

metaR GLCt4
is described by: ECO:0000269
type: Reaction
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR C160CPT2
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: C160 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110018#_f305ae7a_36f4_4bc3_bb8a_40e7f3d4e4f9
constant: false
has only substance units: false
name: GAPDH
is: SBO:0000252
is: E7EUT4
is encoded by: hsa:2597
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_eee21db6_9bbb_4011_a9c5_0e08035f0cc8
constant: false
initial concentration: NaN
type: Species
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
boundary condition: true

metaM so4 m
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: CHEBI:16189

metaM malcoa r
is: HMDB01175
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57384
initial amount: NaN
type: Species
has only substance units: false

metaR TRIODTHYt2
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_de52b418_d979_4d4d_b657_f765b32f6ce8
name: COL4A3BP
boundary condition: true
is: Q9Y5P4
is: SBO:0000252
type: Species
is encoded by: hsa:10087
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR BDHm
is version of: http://identifiers.org/ec-code/1.1.1.30
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
fast: false

metaR ASCBt
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
name: L-ascorbate transport via facilitated diffusion
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#

metaR r0655
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110018#

metaR 4HPRO LTte
type: Reaction
is: SBO:0000185
reversible: true
name: Transport of trans-4-hydroxy-L-proline
product: MODEL1310110018#
is described by: ECO:0000134
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110018#

metaM btamp m
type: Species
is: HMDB04220
boundary condition: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0
constant: false
is: CHEBI:3110
name: Biotinyl-5'-AMP
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
name: adrenyl coenzyme A
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial amount: NaN
is: C16170

metaR FACOAL1822
name: fatty-acid--CoA ligase
is described by: ECO:0000269
reversible: true
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_5768697f_b009_4a2e_a62a_5ea0e8f4e40f
is: P07327
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:124
is: SBO:0000252
boundary condition: true
name: ADH1A
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_28ebdc06_0c67_476d_9775_e3aa5afae6af
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: OCRL
initial concentration: NaN
is encoded by: hsa:4952
boundary condition: true
has only substance units: false

metaR AG13T12g
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110018#

metaM HC00695 m
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: S-Succinyldihydrolipoamide
is: CHEBI:17432

metaR r0051
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
fast: false
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

http://identifiers.org/biomodels.db/MODEL1310110018#_a17d19c3_5f78_4c6b_b146_c22723e1aa30
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10568
name: SLC34A2
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O95436

http://identifiers.org/biomodels.db/MODEL1310110018#_9552b911_af9b_40bf_993f_0fe3dfae38de
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AA576959
constant: false
boundary condition: true
initial concentration: NaN
name: _AA576959_1_c

metaM fuc L c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: L-fucose
type: Species
is: HMDB00174
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaM gthox m
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
is: HMDB03337
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58297

http://identifiers.org/biomodels.db/MODEL1310110018#_3693c867_bbf8_4c28_9186_95440d3c10c8
is: Q9BYZ2
constant: false
name: LDHAL6B
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:92483
type: Species
initial amount: NaN

metaR FACOAL1821
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
name: fatty-acid--CoA ligase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110018#
fast: false

metaR THRCYSNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#

metaM CE2421 m
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
initial concentration: 1.0
boundary condition: false
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
type: Species
has only substance units: false
is: HMDB02329
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_77238ca3_e44f_4c12_ba2d_c66316d882f7
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P27986
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5295
name: PIK3R1

metaM urea e
initial amount: NaN
has only substance units: false
is: C00086
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: HMDB00294
is: SBO:0000247
name: Urea
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16199
type: Species

metaR TYRCBOX
name: L-Tyrosine carboxy-lyase
kinetic law: MODEL1310110018#
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28

http://identifiers.org/biomodels.db/MODEL1310110018#_b650bfa2_d1ce_4f5b_85ea_ed1cbc19d5d4
name: SUOX
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6821
initial amount: NaN
is: P51687
has only substance units: false
constant: false
type: Species

metaM ser D c
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16523
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
name: D-serine
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM mmcoa R m
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: SBO:0000247
is: HMDB01269
is: CHEBI:57326
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false

metaR EX eaflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 8,9 epxoy aflatoxin B1 exchange
type: Reaction

metaR PRPNCOAHYDm
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000134
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110018#

metaR r0911
reversible: true
fast: false
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction

metaR M4MPDOL Uter
name: m4mpdol flippase
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110018#

metaR RE1523M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1523
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000

metaR r1880
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110018#
product: MODEL1310110018#

metaM HC01459 x
constant: false
has only substance units: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:27458

http://identifiers.org/biomodels.db/MODEL1310110018#_2eaa502e_c903_49d5_9d73_c6b4436caf21
is: SBO:0000297
constant: false
name: SPTLC1:SPTLC2
has only substance units: false
initial concentration: NaN
type: Species
has part: O15269
boundary condition: true
is encoded by: hsa:10558
initial amount: NaN
has part: O15270
is encoded by: hsa:9517

metaM fuc L e
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:18287
is: HMDB00174
name: L-fucose
initial amount: NaN

metaR 2HCO3 NAt
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reactant: MODEL1310110018#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_b45efd3f_1a76_49f3_96d5_b92e3ee85b0e
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI620219
name: _AI620219_1_e
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_41fda4ff_c6a8_4991_a0ba_141b36dd06b4
type: Species
is encoded by: hsa:28976
boundary condition: true
name: ACAD9
constant: false
initial concentration: NaN
is: Q9H845
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.41
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000

metaR LNLNCGt
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110018#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_8ae6f3c1_f923_4508_90c2_2b2ecc43be3c
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AA177072
name: _AA177072_1_x
constant: false
initial amount: NaN
is: SBO:0000252

metaM urea c
type: Species
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: CHEBI:16199
is: C00086
initial amount: NaN
name: Urea
is: HMDB00294
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_8f0109f7_9a0c_46fc_b19a_27046afe5309
initial concentration: NaN
name: ALG12
initial amount: NaN
is encoded by: hsa:79087
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q9BV10

metaM arab L c
notes: FORMULA: C5H10O5 CHARGE: 0
has only substance units: false
is: CHEBI:30849
is: HMDB00646
name: L-arabinose
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaM 25aics c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: CHEBI:58443
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00797
is: C04823

http://identifiers.org/biomodels.db/MODEL1310110018#_a9f5fdff_30aa_4b67_b433_cb5ea74e04f2
name: OXCT2
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9BYC2
is encoded by: hsa:64064
boundary condition: true
constant: false

metaR r0226
modifier: MODEL1310110018#
is: SBO:0000176
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a4cd2548_bc89_41b0_9161_1d9a6f08ea00
is: SBO:0000252
type: Species
is: Q15738
name: NSDHL
is encoded by: hsa:50814
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaM 2hexdtricoa m
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
is: SBO:0000247
has only substance units: false
type: Species
name: 2,7,10-hexadecatrienoylcoa

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

metaR ELAIDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
type: Reaction
product: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185

metaR L LACDcm
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria

metaR GLUDym
name: glutamate dehydrogenase (NADP), mitochondrial
fast: false
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110018#

metaM 2maacoa m
name: 2-methylacetoacetyl-CoA(4-)
constant: false
boundary condition: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57335

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaR S4TASE4ly
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
product: MODEL1310110018#

metaM ksi deg8 l
initial amount: NaN
name: keratan sulfate I, degradation product 8
initial concentration: 1.0
is: CHEBI:12936
type: Species
has only substance units: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247
boundary condition: false
is: HMDB00143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a0568e3d_7527_4580_b49b_e2209d01d4f3
type: Species
is: A8K4A0
constant: false
initial concentration: NaN
name: ARSB
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:411

metaR SBT Dtde
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
name: D-sorbitol transport, extracellular

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.8

metaR MTHGXLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110018#
reversible: false
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110018#
name: Methylglyoxal transport (cytosol to extracellular)
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM arab L e
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30849
is: HMDB00646
initial amount: NaN
name: L-arabinose
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_0abac4c8_4e83_43bb_a3b4_67fb07a7fc4c
initial amount: NaN
is encoded by: hsa:8277
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: TKTL1
is: B7Z7I0

http://identifiers.org/biomodels.db/MODEL1310110018#_08848816_237f_4bfe_8531_3c935def0c1a
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
has only substance units: false
initial amount: NaN
constant: false
has part: P27986
type: Species
is: SBO:0000297

metaR GULN3D
is: SBO:0000176
is described by: ECO:0000000
name: L-gulonate 3-dehydrogenase
fast: false
type: Reaction
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaM nh4 x
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C01342
is: HMDB00051
name: Ammonium
constant: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial concentration: 1.0
type: Species

metaM tethex3coa c
is: C16168
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false
type: Species
constant: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_192c4e71_a86f_4c85_8db8_546485904792
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: HSD17B10
boundary condition: true
type: Species
is: Q99714
is encoded by: hsa:3028
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d7978ce1_5d9f_4607_bf02_34afec080bf5
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PDE6H
initial amount: NaN
is encoded by: hsa:5149
is: Q13956
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_e391cbe6_bdd7_4f33_8d55_116fbabf7ee6
type: Species
initial amount: NaN
is: SBO:0000252
name: SCP2
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: C9JC79
is encoded by: hsa:6342

http://identifiers.org/biomodels.db/MODEL1310110018#_96751d31_193f_4eb1_bd5d_d3fea6471470
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: Q71UM8
is encoded by: hsa:108
is: SBO:0000252
has only substance units: false
name: ADCY2

http://identifiers.org/biomodels.db/MODEL1310110018#_1c9c8038_7a68_4e8b_967b_1da6c4a02afa
name: PIGN
is encoded by: hsa:23556
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f3802c8f_50bf_46e6_8da8_28e304e631d1
initial amount: NaN
constant: false
is: Q8IWW8
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: ADHFE1
is encoded by: hsa:137872
initial concentration: NaN

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM pe hs r
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
initial amount: NaN
is: CHEBI:16038

metaM hco3 m
is: CHEBI:17544
is: C00288
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: HMDB00595
name: Bicarbonate
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM ksi deg13 l
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
constant: false
initial concentration: 1.0
is: CHEBI:16953
is: SBO:0000247
initial amount: NaN
is: HMDB00812
name: keratan sulfate I, degradation product 13

metaR EX c12dc
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecanedioyl carnitine
type: Reaction

metaR AMPTASECG
type: Reaction
is: SBO:0000176
name: alanyl aminopeptidase (cys-gly)
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.11.2
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000212
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
reversible: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a21ee88e_b668_46fe_9834_33d11f1ad0a4
initial concentration: NaN
name: PDE5A
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:8654
boundary condition: true

metaR SERASNNaEx
is described by: ECO:0000269
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110018#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
type: Reaction
is: SBO:0000185
fast: false

metaM cholcoads x
type: Species
is: CHEBI:27505
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
boundary condition: false
initial amount: NaN
is: HMDB06889
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
has only substance units: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_772fd534_bbbd_4eac_966b_fdf9a0427e23
type: Species
is: SBO:0000252
name: FASN
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: P49327
has only substance units: false
is encoded by: hsa:2194

metaR FACOAL260
modifier: MODEL1310110018#
is: SBO:0000176
name: fatty-acid--CoA ligase (n-C26:0)
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
fast: false
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110018#
is described by: ECO:0000000

metaR RTOTAL2FATPc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM nh4 n
name: ammonium
is: CHEBI:28938
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00051
type: Species

metaR EHGLAT2m
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
kinetic law: MODEL1310110018#
reversible: false

metaM HC02175 e
is: CHEBI:27689
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
has only substance units: false
initial amount: NaN

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR MECOAS1m
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
fast: false
is: SBO:0000176
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_df9d11a5_fe40_4a97_9a71_53b03bbc15dc
constant: false
is encoded by: hsa:570
name: BAAT
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q14032

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM ksii core2 g
constant: false
has only substance units: false
is: HMDB01014
type: Species
is: SBO:0000247
is: CHEBI:57255
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_899ead33_24fd_4861_8b9d_6e1b6f97407f
has only substance units: false
name: SLCO1C1
type: Species
is encoded by: hsa:53919
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: Q5JPA4
initial amount: NaN

metaR DOLPGT1 Uer
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.267
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110018#
fast: false
type: Reaction

metaR UROLACer
fast: false
is: SBO:0000176
name: uronolactonase, endoplasmic reticulum
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reactant: MODEL1310110018#

metaR GLCAASE9ly
reactant: MODEL1310110018#
name: beta-glucuronidase, lysosomal
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110018#
type: Reaction

metaR PGISr
is described by: ECO:0000134
modifier: MODEL1310110018#
name: Prostaglandin I2 synthase
is version of: http://identifiers.org/ec-code/5.3.99.4
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
is: SBO:0000176
product: MODEL1310110018#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaR ACACT7p
reactant: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
reversible: false
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM cgly c
constant: false
boundary condition: false
is: CHEBI:4047
initial amount: NaN
initial concentration: 1.0
is: HMDB00078
type: Species
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
has only substance units: false

metaR PMANM
reversible: true
is: SBO:0000176
name: phosphomannomutase
type: Reaction
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.8
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#

metaM gthox c
type: Species
name: Oxidized glutathione
boundary condition: false
initial amount: NaN
is: HMDB03337
initial concentration: 1.0
is: C00127
constant: false
is: SBO:0000247
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false

metaM nh4 m
boundary condition: false
is: CHEBI:28938
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
initial concentration: 1.0
name: Ammonium
has only substance units: false
is: HMDB00051
is: SBO:0000247
is: C01342
constant: false

metaR DESAT18 10
fast: false
reactant: MODEL1310110018#
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_8561e00f_9b50_4b26_bf0a_d911663b59b3
name: PDE6G
is: P18545
initial concentration: NaN
is encoded by: hsa:5148
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_73cdcff1_f2ac_4e09_8b1a_41cd9272e9c5
is: Q99944
initial concentration: NaN
is encoded by: hsa:80864
boundary condition: true
constant: false
type: Species
has only substance units: false
name: EGFL8
initial amount: NaN
is: SBO:0000252

metaR RE1254C
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is: SBO:0000176
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
name: RE1254
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR EX CE1940 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine monoaldehyde 2 exchange
type: Reaction

metaR FAOXC103C102m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR r1879
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
name: Y+LAT2 Utilized transport
type: Reaction

metaR r2443
is: SBO:0000185
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reactant: MODEL1310110018#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ab4c0633_3e06_4f2e_a552_aa71e38e0e29
type: Species
initial amount: NaN
has only substance units: false
name: AGA
is: SBO:0000252
is encoded by: hsa:175
boundary condition: true
is: P20933
constant: false
initial concentration: NaN

metaM fgam c
constant: false
is: SBO:0000247
is: HMDB01308
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426
initial amount: NaN
is: C04376

metaR r0917
reversible: true
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_529c8978_14a1_4f79_ba5e_c63617ced5cb
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AA614647
initial concentration: NaN
name: _AA614647_1_c
initial amount: NaN
has only substance units: false
type: Species

metaM prostgd2 r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: prostaglandin D2(1-)
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57406
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403

metaM leuktrB4 e
constant: false
is: HMDB01085
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: leukotriene B4(1-)
is: CHEBI:57461
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0

metaR MACOXO
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
is version of: http://identifiers.org/ec-code/1.4.3.4
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
reversible: false
is: SBO:0000176
type: Reaction
fast: false

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
type: Reaction
reversible: true
product: MODEL1310110018#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR HISCAT1
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM 34hpp c
has only substance units: false
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_fcf2bd28_6f96_4ffc_92f6_99ec0899e084
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: ALDH3A2
is encoded by: hsa:224
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110018#_6ecad7dd_5420_4c60_8a5d_02a52457ad7e
constant: false
initial amount: NaN
name: SLC26A6
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q548A7
is encoded by: hsa:65010

metaR SERt4
reactant: MODEL1310110018#
is described by: ECO:0000269
kinetic law: MODEL1310110018#
name: L-serine via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
fast: false
reversible: false

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false
is: HMDB00019
name: 3-methyl-2-oxobutanoate
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110018#_749755bf_fb87_4e97_b8df_4fbb0b5d5f79
initial concentration: NaN
has only substance units: false
name: ST3GAL5
initial amount: NaN
is encoded by: hsa:8869
type: Species
constant: false
is: SBO:0000252
is: Q9UNP4
boundary condition: true

metaM cgly e
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:4047
is: HMDB00078
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ee1a36f4_f41e_4f10_bae8_3319c34f608f
constant: false
is encoded by: hsa:AL050025
name: _AL050025_1_c
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r2201
type: Reaction
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110018#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM mn l
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
initial amount: NaN
type: Species
name: beta-1,4-mannose-N-acetylglucosamine
constant: false
has only substance units: false
is: HMDB06535

metaM pe hs m
initial amount: NaN
constant: false
is: CHEBI:16038
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaR FAOXC221C201x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR r1722
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f56dd5c4_4576_4831_ab6a_4ef88a613645
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: P22102
name: GART
is: SBO:0000252
is encoded by: hsa:2618
boundary condition: true

metaR PTCRTD
fast: false
name: diffusion of putriscine into the endothelial cells
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reversible: true
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185

metaR LNSTLSr
fast: false
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.99.7
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
name: lanosterol synthase
is: SBO:0000176

metaM leuktrB4 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
is: CHEBI:57461
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: leukotriene B4(1-)
is: SBO:0000247
constant: false

metaM adrncoa c
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A
constant: false
is: C16170
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_985badaa_d6e2_473a_8f3a_ef00397a51be
is encoded by: hsa:9962
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9UGH3
name: SLC23A2
boundary condition: true
type: Species
constant: false

metaR FACOAL1813
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000269
product: MODEL1310110018#
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM dkmpp c
is: SBO:0000247
is: C15650
notes: FORMULA: C6H9O6PS CHARGE: -2
constant: false
type: Species
is: CHEBI:58828
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 2,3-diketo-5-methylthio-1-phosphopentane

metaR r2202
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
reversible: true
is: SBO:0000185

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
name: retinoic acid transport
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_5d595126_0e6f_4df7_a9ed_0343b37ae5ce
name: SLC25A1
type: Species
constant: false
is: D9HTE9
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6576
initial amount: NaN

metaR ACNACNGALGBSIDEtg
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: acnacngalgbside hs intracellular transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true

metaM dsmsterol r
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02719
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
name: desmosterol
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17737

metaR r0774
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: true
name: Active transport
type: Reaction

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM 34hpp e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
constant: false
is: CHEBI:36242
has only substance units: false
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_c91d48ee_dab1_49cb_a6ad_56e0ffc49d1b
name: DPM3
boundary condition: true
initial concentration: NaN
constant: false
is: Q86TM7
initial amount: NaN
is encoded by: hsa:54344
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_316f671b_daad_4206_9853_95a6ea298205
constant: false
boundary condition: true
is: Q9NTN3
name: SLC35D1
is encoded by: hsa:23169
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR r0913
reversible: true
product: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction

metaR r2447
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000185
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
is described by: ECO:0000000
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a3752545_1683_411d_9bec_b9a830be8a6b
name: DBT:DLD:BCKDHA:BCKDHB
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:594
has part: Q9BQL0
type: Species

metaR DTMPK
type: Reaction
reversible: true
fast: false
name: dTMP kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR 4HGLSDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110018#
fast: false
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000212
reactant: MODEL1310110018#
is: SBO:0000176

metaR ILEt5m
is: SBO:0000185
reactant: MODEL1310110018#
fast: false
reversible: true
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR r1147
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_35a7fe9e_f271_4bc4_9b7a_a98b557aa3b0
is encoded by: hsa:4697
is: O00483
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: NDUFA4
has only substance units: false
initial concentration: NaN

metaM ser D e
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB03406
is: SBO:0000247
initial amount: NaN
is: CHEBI:16523
boundary condition: false
name: D-serine

http://identifiers.org/biomodels.db/MODEL1310110018#_09da16bf_341c_49ce_84c3_c12285cc2ae2
name: B3GALT5
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:10317
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM sphmyln hs g
name: sphingomyelin betaine
initial concentration: 1.0
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:58216
has only substance units: false
initial amount: NaN

metaM xol27oh m
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
is: CHEBI:17703
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02103
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

metaR RE3218C
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is: SBO:0000176
reactant: MODEL1310110018#
name: RE3218
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2

metaM HC02175 c
is: CHEBI:27689
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
type: Species
has only substance units: false

metaM chol c
type: Species
initial amount: NaN
constant: false
is: C00114
boundary condition: false
initial concentration: 1.0
is: HMDB00097
name: Choline
is: CHEBI:15354
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR 3SALACBOXL
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.1.1.15
name: 3-Sulfino-L-alanine carboxy-lyase
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.29
is described by: ECO:0000269
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
type: Reaction

metaM 5mdru1p c
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
is: C04582
is: CHEBI:58548
initial amount: NaN
is: SBO:0000247
is: HMDB01299
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C6H11O7PS CHARGE: -2
type: Species

metaR DCK2n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
is described by: ECO:0000269
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaR ACNACNGALGBSIDEte
product: MODEL1310110018#
reactant: MODEL1310110018#
name: acnacngalgbside hs transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
kinetic law: MODEL1310110018#

metaR PROD2m
is described by: ECO:0000254
product: MODEL1310110018#
name: Proline dehydrogenase (m)
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
reversible: false
reactant: MODEL1310110018#

metaR GTHDH
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
type: Reaction
name: Glutathione dehydrogenase (dehydroascorbate reductase)
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110018#
reversible: false

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
fast: false

metaR r1589
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_7e75de28_99f9_4a85_8463_3587e2bf974e
type: Species
name: ABAT
initial concentration: NaN
is: P80404
is encoded by: hsa:18
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR S6T17g
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_34741613_4fb0_4c8c_82fb_c7f9af55fc38
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI656480
name: _AI656480_1_m
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM malcoa c
is: C00083
initial concentration: 1.0
type: Species
is: CHEBI:57384
has only substance units: false
initial amount: NaN
name: Malonyl-CoA
is: HMDB01175
constant: false
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false

metaR 2MCITt
is described by: ECO:0000000
name: 2-methylcitrate transport via diffusion
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
kinetic law: MODEL1310110018#

metaM L2aadp6sa c
is: CHEBI:17917
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01263
name: L-allysine

metaM ksii core2 l
type: Species
initial amount: NaN
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
is: HMDB01014
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM aps c
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:58243
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: HMDB01003
name: 5'-adenylyl sulfate(2-)

metaR r0915
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_fe124bcb_91fb_4b53_993e_99329511f9e4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51179
name: HAO2
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM glx c
is: CHEBI:36655
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
initial amount: NaN
is: SBO:0000247
name: glyoxylate
boundary condition: false
initial concentration: 1.0
is: HMDB00119
type: Species

metaR LEULEULAPc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR r1587
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110018#_2ac0df26_708e_4026_a9ac_9e16f34f2a91
is: Q9BT22
is: SBO:0000252
is encoded by: hsa:56052
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: ALG1
constant: false
type: Species

metaR r1257
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
fast: false
name: EC:6.2.1.3
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e5a2002c_9a72_4ffc_ae32_3a8ffd03a0e0
constant: false
name: CA4
initial concentration: NaN
has only substance units: false
is: Q6FHI7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:762
type: Species
initial amount: NaN

metaR TXA2tr
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
is described by: ECO:0000000
name: thromboxane A2 intracellular transport
type: Reaction
is: SBO:0000185
product: MODEL1310110018#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9dd8d965_f3a8_42cc_a9dc_9055eb2661e4
boundary condition: true
initial concentration: NaN
type: Species
name: CD38
is encoded by: hsa:952
is: SBO:0000252
constant: false
has only substance units: false
is: P28907
initial amount: NaN

metaR ETFQO
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.5.5.1
reversible: false
reactant: MODEL1310110018#

metaM docosahexcoa m
is: SBO:0000247
has only substance units: false
name: 3,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR MI145PK
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110018#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR ATP1ter
kinetic law: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
name: ADP/ATP transporter, endoplasmic reticulum
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true

metaM chol e
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
name: Choline
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15354
initial amount: NaN
is: HMDB00097
constant: false
is: C00114
initial concentration: 1.0

metaM fru c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
is: CHEBI:15824
name: D-Fructose
constant: false
has only substance units: false
initial amount: NaN
is: C00095
is: HMDB00660
initial concentration: 1.0

metaM 1pyr5c m
has only substance units: false
type: Species
is: C03912
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: HMDB01301
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0

metaR FAOXC2251836m
reversible: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176

metaR OCTAt
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
name: Octanoate transport via diffusion
reversible: true
type: Reaction

metaM focytC m
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Ferrocytochrome C
constant: false
initial amount: NaN
type: Species
is: CHEBI:16928
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_b91c115d_c497_4c2c_bd02_7c148b150e83
is: SBO:0000252
type: Species
name: SLC29A2
is encoded by: hsa:3177
boundary condition: true
has only substance units: false
is: Q14542
constant: false
initial concentration: NaN
initial amount: NaN

metaR RE2349C
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
name: RE2349
reversible: true
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
fast: false
is described by: ECO:0000000

metaR DNDPt36m
name: dGDP transport via dCDP antiport
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
fast: false
product: MODEL1310110018#

metaR r1588
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nh4 e
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: ammonium
is: HMDB00051
type: Species
is: CHEBI:28938
has only substance units: false

metaR r1435
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
name: Transport reaction
reversible: false
is: SBO:0000185

metaM memgacpail hs r
type: Species
is: CHEBI:57977
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00054
initial concentration: 1.0
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3a8cfe85_f28f_400e_b3cd_c948438851be
has only substance units: false
is: Q5JWV8
constant: false
is encoded by: hsa:2182
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ACSL4
initial concentration: NaN

metaM c8dc c
has only substance units: false
constant: false
name: suberyl carnitine
is: C14143
type: Species
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB04047

metaM 3mob c
has only substance units: false
name: 3-methyl-2-oxobutanoate
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:11851
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_d1951c18_7638_4563_9b19_04f02b3e6b03
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q16773
is: SBO:0000252
type: Species
name: CCBL1
boundary condition: true
constant: false
is encoded by: hsa:883

metaM dcsptn1coa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
has only substance units: false
is: C16173

metaM L2aadp m
name: L-2-aminoadipate(1-)
is: CHEBI:58672
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
boundary condition: false
is: HMDB00510
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR NRVNCCOAtx
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
reactant: MODEL1310110018#
name: fatty acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f6011efa_af96_4c14_8650_bfcc0b6129cc
initial concentration: NaN
has part: P38117
boundary condition: true
is encoded by: hsa:2109
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: ETFA:ETFB
is: SBO:0000297

metaR r1585
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_02cd7cd1_8e55_4b59_bc9e_e4845d78c92f
initial amount: NaN
boundary condition: true
name: SYNJ2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: O15056
is encoded by: hsa:8871
constant: false

metaM arach c
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
initial concentration: 1.0
is: CHEBI:32360
constant: false
name: arachidate
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_f2c9a404_045d_448f_9d75_37cbe37a077e
is: Q6FGA0
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9167
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: COX7A2L

metaM sphmyln hs c
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: CHEBI:58216
is: SBO:0000247
name: sphingomyelin betaine
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_2c96d8bb_c5c5_4337_bf6c_e887b00e461f
type: Species
initial concentration: NaN
is encoded by: hsa:400410
initial amount: NaN
boundary condition: true
has only substance units: false
name: ST20
is: SBO:0000252
is: Q9HBF5
constant: false

metaM prgnlone m
constant: false
is: CHEBI:16581
name: pregnenolone
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
boundary condition: false
initial amount: NaN
is: HMDB00253
is: SBO:0000247

metaR GLAl
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.22
name: galactosidase, alpha
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
product: MODEL1310110018#

metaR LEUTA
kinetic law: MODEL1310110018#
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reversible: true
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110018#
type: Reaction

metaR r1433
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
fast: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:

metaM nh4 c
boundary condition: false
name: Ammonium
initial concentration: 1.0
is: C01342
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00051
is: SBO:0000247
type: Species
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM CE2424 m
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false
has only substance units: false
is: HMDB11123
is: CHEBI:28387
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
constant: false
initial amount: NaN

metaR r1586
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
product: MODEL1310110018#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HISTAtu
fast: false
type: Reaction
name: Histamine uniport
is described by: ECO:0000269
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d84979fd_529f_42bd_9adb_8a1507e14174
boundary condition: true
has only substance units: false
name: ACAT2
is: SBO:0000252
is: Q9BWD1
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:39

metaR LNELDCt
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

metaR NDP7ex
name: nucleoside-diphosphatase (UDP), extracellular
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110018#
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
type: Reaction

metaM 3mob e
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
is: HMDB00019
name: 3-methyl-2-oxobutanoate
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:11851
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_3b20c8d3_97b0_416f_87d9_d4a4e656ed12
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P21912
is encoded by: hsa:6390
name: SDHB
constant: false
boundary condition: true

metaM pe hs e
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110018#_b091f759_b4b7_459c_940b_0bdfb523bab9
is: Q9HC58
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:57419
constant: false
name: SLC24A3
initial concentration: NaN
boundary condition: true

metaM c8dc e
is: SBO:0000247
is: HMDB04047
boundary condition: false
name: suberyl carnitine
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: C14143
notes: FORMULA: C15H26NO6 CHARGE: -1
type: Species

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaM sucsal m
has only substance units: false
boundary condition: false
initial amount: NaN
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
constant: false
is: SBO:0000247
is: HMDB01259
is: CHEBI:57706
type: Species
initial concentration: 1.0

metaM acetol c
initial amount: NaN
boundary condition: false
name: hydroxyacetone
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27957
is: HMDB06961
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
has only substance units: false

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176

metaR RE2998M
is described by: ECO:0000000
name: RE2998
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110018#_a6e81ed1_6ba1_4751_898f_49f7282e2fc8
is: P51648
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ALDH3A2
constant: false
is encoded by: hsa:224
has only substance units: false
type: Species
boundary condition: true

metaR OMHPALTD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR ADPRIBt
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:IT
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.2.5
name: ADPribose transport

metaR PPA
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
reversible: false
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM gmp n
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB01397
is: SBO:0000247
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
boundary condition: false
name: GMP(3-)

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_82084a1a_2907_43a4_a071_23f49b415224
is: Q16877
name: PFKFB4
boundary condition: true
has only substance units: false
is encoded by: hsa:5210
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaM CE2417 m
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: SBO:0000247
boundary condition: false
is: CHEBI:28387
initial concentration: 1.0
initial amount: NaN
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
has only substance units: false
constant: false

metaR r1584
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0660
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.2
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#

metaR MI145PP
name: inositol-1,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is: SBO:0000176
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110018#
type: Reaction
fast: false
reversible: false
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR RE3001M
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110018#
name: RE3001
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110018#

metaR GLCter
fast: false
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true

metaM cys L e
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
is: CHEBI:17561
initial concentration: 1.0
name: L-cysteine
is: HMDB00574
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM L2aadp6sa m
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
is: HMDB01263
initial concentration: 1.0
is: CHEBI:17917
name: L-allysine

metaM pe hs c
boundary condition: false
name: phosphatidylethanolamine
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
is: CHEBI:16038
has only substance units: false

metaR FAOXC163C164Gm
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR ALDD2xm
reactant: MODEL1310110018#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reversible: false

metaM ksi deg10 l
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16953
initial amount: NaN
name: keratan sulfate I, degradation product 10
is: HMDB00812
is: SBO:0000247
type: Species
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
boundary condition: false

metaR r1581
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_cc6698ec_3583_49df_a6c4_f54041b13a62
is: P00441
is encoded by: hsa:6647
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: SOD1
initial concentration: NaN

metaR DDPGAm
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD

metaM ksi pre8 g
boundary condition: false
has only substance units: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
type: Species
name: keratan sulfate I biosynthesis, precursor 8
is: CHEBI:28067
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM fru e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
constant: false
boundary condition: false
initial amount: NaN
is: C00095
has only substance units: false
is: HMDB00660
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_6f4647ba_a4ea_443e_a193_67bd22926a39
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PTEN
type: Species
is: F6KD01
is encoded by: hsa:5728
initial amount: NaN
initial concentration: NaN

metaR UMPK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
name: UMP kinase (dCTP),nuclear
type: Reaction
fast: false

metaM ksi deg9 l
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 9
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_419ca5b5_7415_47ce_979a_d08e854a25d9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:482
constant: false
initial amount: NaN
name: ATP1A3:ATP1B2
boundary condition: true
is: SBO:0000297
has part: P14415
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_b254a1ee_d9e2_4f6f_9af2_8242dc835d66
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5151
name: PDE8A
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000

metaR DCYTDn
reversible: false
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110018#
is described by: ECO:0000254
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
name: deoxycytidine deaminase, nuclear

metaM cys L c
initial concentration: 1.0
name: L-cysteine
type: Species
is: CHEBI:17561
is: HMDB00574
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
has only substance units: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_189011c8_1d6d_496d_b5e9_a293346ac253
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10327
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: AKR1A1

metaM fe2 c
constant: false
is: CHEBI:29033
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00023
initial amount: NaN
name: Fe2+
is: HMDB00692
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
type: Species

metaR OLEICFATPtc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2f79fad5_0015_4437_bcc8_41342c2984f1
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC9A1
is encoded by: hsa:6548
is: P19634
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_37774219_c1b7_4644_9213_1923da383846
name: SUCLG1:SUCLA2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8803
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000297
has part: E5KS60

http://identifiers.org/biomodels.db/MODEL1310110018#_2a5ea1b7_8aad_48b6_84e5_f80aea8f6a58
name: LHPP
initial amount: NaN
has only substance units: false
is: Q9H008
initial concentration: NaN
is encoded by: hsa:64077
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR DTDPtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dTDP nuclear transport
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
fast: false
product: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR P450SCC1m
product: MODEL1310110018#
name: cholesterol monooxygenase
type: Reaction
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

metaR NDPK8n
fast: false
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_f1f80a0f_5bcc_40e0_9d65_74ef7d85f819
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:79646
is: Q9H999
name: PANK3
initial concentration: NaN

metaR r1590
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR FDH
product: MODEL1310110018#
fast: false
name: formate dehydrogenase
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.6
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110018#

metaR RE1533M
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_3a8646c1_436e_4597_b4d3_f7527a4c5ca4
is: P36957
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: DLST
initial concentration: NaN
is encoded by: hsa:1743
type: Species
constant: false
has only substance units: false

metaR HDD2COAtx
name: hdd2coa intracellular transport
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_272e01c1_78b8_4c1d_8a61_f24e65b3c780
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:206358
is: Q1LZ56
initial concentration: NaN
name: SLC36A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ced4679c_6aad_4b5e_94f5_fa6b09e4da22
constant: false
is encoded by: hsa:AI090874
boundary condition: true
initial concentration: NaN
name: _AI090874_1_c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM o2s x
is: HMDB02168
name: superoxide
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: CHEBI:18421
type: Species
boundary condition: false
initial concentration: 1.0

metaR DESAT16 2
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d7bd8ff7_3cc8_4c51_9d3c_174d5c49f829
name: _D29675_1_e
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:D29675
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 7dhchsterol r
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
is: HMDB00032
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
type: Species

metaR TMDPP
type: Reaction
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.4
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
is described by: ECO:0000269
name: thymidine phosphorylase
reactant: MODEL1310110018#

metaM 3aib m
constant: false
is: CHEBI:33094
boundary condition: false
is: HMDB02166
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaM nac c
name: Nicotinate
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
is: CHEBI:0
constant: false
is: SBO:0000247
is: HMDB01488
initial amount: NaN
initial concentration: 1.0

metaM pyr c
has only substance units: false
name: pyruvate
is: SBO:0000247
constant: false
is: HMDB00243
initial amount: NaN
is: CHEBI:15361
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
type: Species
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1
is: C00022

metaM txa2 c
has only substance units: false
is: CHEBI:57445
initial concentration: 1.0
constant: false
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01452

http://identifiers.org/biomodels.db/MODEL1310110018#_efb75602_6c6d_426f_9fcf_d1878b74020a
name: PIGP
initial concentration: NaN
type: Species
is encoded by: hsa:51227
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r0647
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
fast: false
name: Spontaneous reaction
is described by: ECO:0000000

metaR KCCt
fast: false
modifier: MODEL1310110018#
is: SBO:0000185
reversible: true
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM lald L c
name: (S)-lactaldehyde
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:18041
initial concentration: 1.0
is: HMDB03052
initial amount: NaN
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: SBO:0000247

metaM 5aizc c
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: CHEBI:58564
is: HMDB06273
initial amount: NaN
type: Species
is: C04751
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
boundary condition: false

metaM gpi sig r
is: HMDB00224
is: CHEBI:58190
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
notes: FORMULA: Y CHARGE: 0
constant: false
initial amount: NaN

metaM fe2 e
is: C00023
has only substance units: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
is: HMDB00692
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Fe2+
boundary condition: false
initial amount: NaN
constant: false

metaM glx m
name: glyoxylate
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:36655
has only substance units: false
initial amount: NaN
is: HMDB00119
is: SBO:0000247
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

metaM ksii core4 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
notes: FORMULA: C69H112N6O48X CHARGE: -1
initial amount: NaN
has only substance units: false
is: CHEBI:2504
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06552

metaR r1592
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ASNGLNNaEx
reversible: false
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is: SBO:0000185
modifier: MODEL1310110018#

metaR FACOAL181i
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: C181 fatty acid activation
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000269

metaR IPDDIx
type: Reaction
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.3.3.2
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
is described by: ECO:0000134
product: MODEL1310110018#
name: isopentenyl-diphosphate D-isomerase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_51e770c0_9918_4209_86cf_b59e5ebefbf4
is: Q96CA6
initial amount: NaN
constant: false
type: Species
name: ACAA1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:30
has only substance units: false
initial concentration: NaN

metaR UMPK7n
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
name: UMP kinase (dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#

metaR r1591
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_4d530eb2_0801_47a6_9702_e0ae3b8ba0ed
is encoded by: hsa:3992
name: FADS1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: O60427
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f33eea59_880a_4f4e_a1de_c7faefaa05cb
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q96CA6
constant: false
is encoded by: hsa:30
name: ACAA1
boundary condition: true

metaM ksi deg26 l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061
constant: false
is: CHEBI:58343
name: keratan sulfate I, degradation product 26
boundary condition: false

metaR AG13T2g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
reactant: MODEL1310110018#
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#

metaM prostgd2 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: prostaglandin D2(1-)
is: SBO:0000247
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
constant: false
is: HMDB01403

metaR C4STMO1r
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110018#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.13.72
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#

metaM txa2 e
is: CHEBI:57445
initial concentration: 1.0
has only substance units: false
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01452
boundary condition: false
constant: false

metaM hs deg4 l
constant: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
has only substance units: false
is: SBO:0000247
name: heparan sulfate, degradation product 4
boundary condition: false
is: CHEBI:16126
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_8e9ea181_9129_468e_bf87_28ed5eb0e15c
name: BCAT2
boundary condition: true
is: O15382
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:587

metaR LYStm
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Lysine mitochondrial transport via ornithine carrier
modifier: MODEL1310110018#
reversible: true

metaR AG13T13g
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110018#

metaM orn e
boundary condition: false
name: Ornithine
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
constant: false
is: C01602
is: HMDB00214
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:0

metaR r0642
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d01fce1e_ef41_4d6a_8069_03570135a41f
is: SBO:0000252
initial amount: NaN
name: SLC17A3
boundary condition: true
initial concentration: NaN
is: O00476
constant: false
type: Species
has only substance units: false
is encoded by: hsa:10786

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR CYSSERNaEx
reactant: MODEL1310110018#
fast: false
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110018#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_88c4c390_2272_4b7e_a41b_0afa1bd1ded5
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6185
has part: P04844
is encoded by: hsa:1650
name: DAD1:DDOST:RPN1:RPN2
has part: Q53G02
has part: P39656
is encoded by: hsa:6184
boundary condition: true
has part: P04843
is: SBO:0000297
is encoded by: hsa:1603
initial concentration: NaN

metaR r0321
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.3.5.2
is: SBO:0000176
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
product: MODEL1310110018#

metaR NTP3e
reversible: false
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
name: nucleoside-triphosphatase (GTP)
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176

metaR KAS8
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110018#

metaR GLYCLTtp
product: MODEL1310110018#
name: glycolate transport into peroxisome
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110018#

metaR LNELDCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2eb71c0f_2771_490a_afcf_782fd22ea482
constant: false
type: Species
is encoded by: hsa:51
initial concentration: NaN
boundary condition: true
name: ACOX1
is: SBO:0000252
is: B4DK61
initial amount: NaN
has only substance units: false

metaR S3TASE2ly
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000

metaR FERO
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
product: MODEL1310110018#
is: SBO:0000176
name: ferroxidase
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
type: Reaction

metaM orn c
initial concentration: 1.0
name: Ornithine
is: HMDB00214
is: C01602
is: CHEBI:0
type: Species
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3c92467f_5f80_48ea_a2f7_26062ecfc075
initial amount: NaN
is: E7EPT3
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ALDH7A1
is encoded by: hsa:501
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_714ff49f_a100_4404_b464_21933db1153d
name: PPT1
is encoded by: hsa:5538
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q6FGQ4
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR r0643
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR CSPG Atly
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: chondroitin sulfate A transport, extracellular to lysosome
reactant: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_5d509c72_c20f_477b_a7f8_fddc2c339700
is encoded by: hsa:4696
boundary condition: true
initial concentration: NaN
name: NDUFA3
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: O95167

metaM prostgd2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
initial concentration: 1.0
type: Species
name: prostaglandin D2(1-)
is: CHEBI:57406
initial amount: NaN
is: HMDB01403
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR HSD17B4x
reversible: false
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is described by: ECO:0000269
reactant: MODEL1310110018#

metaR FAOXC226C205m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c34c71b9_afaf_4676_86c5_77889d35dc32
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: HSD11B2
is encoded by: hsa:3291
has only substance units: false
constant: false
initial concentration: NaN
is: P80365

metaR SERGLNexR
is described by: ECO:0000304
product: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
name: L-Serine/Glutamine reversible exchange
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM dctp c
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
name: dCTP
is: CHEBI:16311
is: SBO:0000247
is: HMDB00998
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3759f736_3f05_4dcd_b8d0_879bb204957a
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: PIK3C2G
initial amount: NaN
is: O75747
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5288

metaR FRDPtcr
is: SBO:0000185
is described by: ECO:0000134
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaM h2o2 m
is: C00027
has only substance units: false
constant: false
name: Hydrogen peroxide
initial amount: NaN
is: HMDB03125
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: CHEBI:16240
type: Species

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR r0644
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
fast: false
reactant: MODEL1310110018#
type: Reaction
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110018#

metaM 34dhmald c
is: C05577
type: Species
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
is: HMDB06242

metaM gluala e
initial amount: NaN
type: Species
name: 5-L-Glutamyl-L-alanine
is: HMDB06248
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6503
constant: false
boundary condition: false
is: C03740
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_6f12bff7_9521_40c7_b7fc_1a523a9263b7
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2544
name: _2544_1_c

metaM ha pre1 l
type: Species
is: SBO:0000247
is: CHEBI:16126
constant: false
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR MI14P4P
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reversible: false
name: inositol-1,4-bisphosphate 4-phosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
product: MODEL1310110018#
fast: false
type: Reaction
reactant: MODEL1310110018#

metaM h2o2 n
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
type: Species
has only substance units: false
is: HMDB03125
initial concentration: 1.0
name: hydrogen peroxide

metaR ARAB Lt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
type: Reaction
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
name: L-arabinoase extracellular transport
fast: false
kinetic law: MODEL1310110018#

metaM sgalside hs c
is: CHEBI:16523
is: HMDB03406
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
has only substance units: false
is: SBO:0000247
name: sulfatide galactocerebroside
initial amount: NaN

metaM acgal1p c
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
type: Species
initial amount: NaN
name: N-Acetyl-D-galactosamine 1-phosphate
is: CHEBI:55404
is: SBO:0000247
is: HMDB06480

http://identifiers.org/biomodels.db/MODEL1310110018#_0ff4b9c3_dff1_42c2_a4f9_b144de3beb11
is: Q15111
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:5334
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PLCL1

http://identifiers.org/biomodels.db/MODEL1310110018#_2c8a7d9c_26b9_4441_acce_440b4a4ec162
is encoded by: hsa:5147
initial concentration: NaN
has part: P18545
type: Species
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
has only substance units: false
is encoded by: hsa:5148
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN
has part: O43924

metaM crn c
is: SBO:0000247
has only substance units: false
boundary condition: false
name: L-Carnitine
constant: false
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
is: HMDB00062
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_2f58d008_d13d_41f8_923e_555ed8e8a8b1
is encoded by: hsa:191
boundary condition: true
initial concentration: NaN
is: B3KUN3
initial amount: NaN
name: AHCY
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_5700503e_4b35_4d2b_a619_d99d34c9d594
is: Q99808
is: SBO:0000252
is encoded by: hsa:2030
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC29A1
boundary condition: true

metaR GTHP
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.11.1.15
reversible: true
name: glutathione peroxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8f95a8e2_d4e1_47e4_985b_99f1567b03b3
has only substance units: false
is: P04745
initial amount: NaN
constant: false
is encoded by: hsa:278
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: AMY1C

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR GLUDxm
type: Reaction
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3

metaR PDE4
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
reactant: MODEL1310110018#
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110018#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_81896a3d_768d_4bbe_bcf2_e0c2cd8518ef
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: O95168
is encoded by: hsa:4710
initial amount: NaN
name: NDUFB4
has only substance units: false
type: Species

metaR r1154
fast: false
type: Reaction
is described by: ECO:0000000
name: EC:1.2.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#

metaR HPYRDC
is: SBO:0000176
name: hydroxypyruvate decarboxylase
reactant: MODEL1310110018#
type: Reaction
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
is described by: ECO:0000000

metaR CLPNDt
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: fatty acid transport via diffusion

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_3c92adc5_f8fa_462f_9254_6fa1fa95c2e1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: O75354
boundary condition: true
is encoded by: hsa:955
name: ENTPD6

metaR r0752
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
product: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110018#

metaM retinol 9 cis c
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17336
name: 9-cis-retinol
is: HMDB06217
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

metaR GGH 6THFe
name: Gamma-glutamyl hydrolase (6THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
reversible: false

metaR GLNS
reactant: MODEL1310110018#
name: glutamine synthetase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
is described by: ECO:0000254
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_87de4377_d50f_4c1d_9cf0_3d8bcdc3f47b
name: CA7
is: Q86YU0
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:766
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_8ba78bd1_2803_462f_835a_7f91260255ef
is encoded by: hsa:57665
is: Q9HBH5
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: RDH14
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_f11a3f6f_3f2d_4f13_8b2b_156dea0c886d
is encoded by: hsa:2645
constant: false
name: GCK
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: Q53Y25
initial concentration: NaN
has only substance units: false

metaM fe2 m
type: Species
name: Fe2+
is: HMDB00692
is: CHEBI:29033
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
initial amount: NaN
boundary condition: false
has only substance units: false

metaM oxa e
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:30623
is: HMDB02329
has only substance units: false
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN

metaM g3m8masn r
boundary condition: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
constant: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05873
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_57b0fc5d_8fda_466c_aeac_1e38b78c90d4
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2530
is: Q546E0
constant: false
is: SBO:0000252
type: Species
name: FUT8
initial amount: NaN

metaR r1155
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
reversible: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110018#_ad399e76_eca5_40c3_855b_98e4b2e78a8e
type: Species
initial concentration: NaN
name: SLC23A2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:9962
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_3baaa4f0_94ea_4efe_a497_5d3de4512017
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: ALG2
type: Species
is encoded by: hsa:85365
has only substance units: false
is: SBO:0000252

metaM o2s m
initial concentration: 1.0
is: CHEBI:18421
constant: false
is: HMDB02168
boundary condition: false
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: SBO:0000247
type: Species
name: Superoxide anion
initial amount: NaN

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
is described by: ECO:0000134
product: MODEL1310110018#
name: Isopentenyl diphosphate transport (peroxisome)
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
reactant: MODEL1310110018#
fast: false
is: SBO:0000185

metaR r0753
product: MODEL1310110018#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM hmbil c
is: HMDB01137
is: C01024
initial amount: NaN
is: SBO:0000247
name: Hydroxymethylbilane
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: CHEBI:57845

metaR H6ET3er
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.8.1
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_8b0376ad_b547_40fa_8e03_259cf9dc13f2
is encoded by: hsa:4705
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFA10
is: O95299
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_809d92bd_3c3a_4c82_82e7_a4e12ef8443b
is: P04746
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:279
initial amount: NaN
name: AMY2A
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_64b50984_aab7_41b7_b3f5_566e679a442f
is: SBO:0000252
name: _W74642_1_c
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:W74642
has only substance units: false

metaM pan4p m
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
initial concentration: 1.0
name: pantetheine 4'-phosphate(2-)

metaR NACHEX12ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d8cba9b7_22fd_4e7f_9ad1_bc447ec8bf1d
name: ACADL
is encoded by: hsa:33
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: P28330
constant: false

metaR TMDPK
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.6.2
type: Reaction
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
name: Thiamin pyrophosphokinase (EC 2.7.6.2)

metaR GLNASNNaEx
reversible: false
product: MODEL1310110018#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185

metaM co e
initial concentration: 1.0
is: HMDB01361
type: Species
has only substance units: false
constant: false
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial amount: NaN
boundary condition: false
name: carbon monoxide
is: SBO:0000247

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM co c
name: carbon monoxide
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01361
type: Species
is: CHEBI:17245
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
reversible: true
fast: false
type: Reaction

metaR GTHO
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: glutathione oxidoreductase
product: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254

metaR r0754
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c1699cb4_5dff_4d08_b7ed_4c3a26a3dab6
initial amount: NaN
boundary condition: true
is: E7ET32
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2592
is: SBO:0000252
constant: false
type: Species
name: GALT

metaM o2s n
name: superoxide
boundary condition: false
is: CHEBI:18421
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
type: Species
is: HMDB02168
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_cb25e726_2619_4a3d_8c96_3257c74ffed5
name: PIGC
is: SBO:0000252
boundary condition: true
is: Q92535
has only substance units: false
type: Species
is encoded by: hsa:5279
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c15c20f2_433d_4384_aef6_9ff1db3ff26c
type: Species
name: IDH1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3417
constant: false
is: O75874
boundary condition: true

metaM sgalside hs g
is: CHEBI:58343
name: sulfatide galactocerebroside
constant: false
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: SBO:0000247
boundary condition: false
is: HMDB00061
initial concentration: 1.0
initial amount: NaN
type: Species

metaR AHEXASE2ly
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110018#_7b09e25d_0a6c_4368_a017_b58802b6bfd1
has only substance units: false
initial amount: NaN
is: Q16718
name: NDUFA5
boundary condition: true
is encoded by: hsa:4698
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM C05965 e
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB04243
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: CHEBI:57444
name: 12(S)-HPETE(1-)
type: Species

metaR RE1448N
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
kinetic law: MODEL1310110018#
reversible: true
name: RE1448
fast: false
reactant: MODEL1310110018#

metaR GBAl
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
reversible: false
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.45
name: Glucosylceramidase

metaM ksii core2 pre4 g
is: HMDB06552
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:2504
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
boundary condition: false
constant: false

metaM fn2m2masn g
constant: false
type: Species
initial amount: NaN
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32984
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247

metaR PPPGOm
is described by: ECO:0000304
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
reversible: false
name: protoporphyrinogen oxidase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.3.4
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD

metaM ha pre1 e
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
constant: false
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0755
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000000

metaR LYStiDF
name: L-lysine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
reversible: false

metaM oxa c
initial amount: NaN
name: oxalate(2-)
constant: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
is: CHEBI:30623
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM oaa c
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
is: SBO:0000247
name: Oxaloacetate
initial concentration: 1.0
type: Species
is: HMDB00223
is: CHEBI:3338
constant: false
is: C00036

metaM dcsptn1coa m
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C16173

metaM h2o2 c
is: C00027
type: Species
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125
is: SBO:0000247
constant: false
is: CHEBI:16240
initial amount: NaN
name: Hydrogen peroxide
initial concentration: 1.0

metaM 4hexdtetcoa m
has only substance units: false
name: 4,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
initial amount: NaN

metaR KSIt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110018#
name: keratan sulfate I transport, golgi to extracellular
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR FACOAL1832
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110018#_5d7dc698_1b63_41db_a474_0789a47d6066
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2352
name: FOLR3
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q05C14

http://identifiers.org/biomodels.db/MODEL1310110018#_e4a8f1e3_22e9_41e9_9cc0_34baec188e2f
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4724
name: NDUFS4
initial concentration: NaN
is: O43181
initial amount: NaN

metaR IDOURte
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true
product: MODEL1310110018#
type: Reaction
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: L-iduronate transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110018#_4991e5cf_a0b9_4146_af0b_2504104ee87a
initial concentration: NaN
initial amount: NaN
constant: false
name: CAT
is encoded by: hsa:847
is: SBO:0000252
is: P04040
type: Species
boundary condition: true
has only substance units: false

metaR r0756
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR FAOXC205C185m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM dctp n
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
is: CHEBI:16311
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00998
is: SBO:0000247
constant: false
has only substance units: false
is: C00458
boundary condition: false

metaR FACOAL1831
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110018#
name: fatty-acid--CoA ligase
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d144dece_7f40_408f_8913_4422d7d9e35c
name: ACADS
has only substance units: false
is: P16219
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:35
type: Species

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR THFtm
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110018#
is: SBO:0000185

metaM ksii core2 e
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
initial concentration: 1.0
is: CHEBI:17268
constant: false
is: HMDB00211
name: keratan sulfate II (core 2-linked)
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0757
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
type: Reaction
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_223b65e6_1eb7_4c60_8d5f_daa66eaf1471
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q9NRA2
is encoded by: hsa:26503
constant: false
initial amount: NaN
name: SLC17A5

http://identifiers.org/biomodels.db/MODEL1310110018#_9af9d6ac_be0d_4029_b281_dfd6d51b709b
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10841
has only substance units: false
name: FTCD
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR DADNt4
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyadenosine transport via diffusion
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000

metaR H2Oter
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
name: H2O endoplasmic reticulum transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR ASNCYSNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is described by: ECO:0000269
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_e790d0a3_1b53_472c_8597_8d38288c50d7
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: HAS2
is: Q92819
has only substance units: false
boundary condition: true
is encoded by: hsa:3037
constant: false

metaM h2o2 e
initial concentration: 1.0
name: hydrogen peroxide
type: Species
boundary condition: false
has only substance units: false
is: HMDB03125
is: SBO:0000247
constant: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_086d448d_7c73_44f9_a314_7cc060e09e60
constant: false
type: Species
name: UROD
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7389
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P06132

metaM 3aib D m
constant: false
boundary condition: false
name: D-3-Amino-isobutanoate
has only substance units: false
is: HMDB02299
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
initial concentration: 1.0
is: C03265

http://identifiers.org/biomodels.db/MODEL1310110018#_726f142a_c09b_4ed4_beb3_63ab25b97cd5
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:594
constant: false
is: P21953
is: SBO:0000252
boundary condition: true
name: BCKDHB
initial concentration: NaN

metaM 2kmb c
name: 2-keto-4-methylthiobutyrate
initial concentration: 1.0
is: HMDB01553
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16723
constant: false
initial amount: NaN
notes: FORMULA: C5H7O3S CHARGE: -1

metaR RE3520E
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
name: RE3520
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:

metaR SIAT9g
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.9
fast: false
product: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000000
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus

metaM no e
is: SBO:0000247
is: CHEBI:16480
name: Nitric oxide
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
has only substance units: false
is: C00533
is: HMDB03378
constant: false

metaR RE1522M
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110018#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
name: RE1522

metaM nac e
is: HMDB01488
name: Nicotinate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00253
is: CHEBI:0
constant: false
boundary condition: false
notes: FORMULA: C6H4NO2 CHARGE: -1
type: Species
is: SBO:0000247

metaR DINt
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
name: deoxyinosine transport via diffusion
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000

metaR FACOAL161
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
name: fatty-acid--CoA ligase (hexadecenoate)
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110018#
reversible: true

metaR ACACt2
fast: false
name: acetoacetate transport via proton symport
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is: SBO:0000185

metaM mi1345p c
type: Species
is: CHEBI:57895
boundary condition: false
has only substance units: false
is: HMDB01059
initial amount: NaN
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
is: SBO:0000247
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)

http://identifiers.org/biomodels.db/MODEL1310110018#_b0816612_6310_4b78_b140_bd922088b2dc
name: HAO2
is: Q9NYQ3
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:51179
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM btcoa m
is: HMDB01088
boundary condition: false
initial amount: NaN
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
type: Species
is: CHEBI:57371
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00136

metaM glx x
constant: false
is: HMDB00119
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: glyoxylate
type: Species
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.4.17
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
reactant: MODEL1310110018#
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM dhcholestancoa x
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: HMDB02159
type: Species
is: CHEBI:15494

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaM oaa x
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: C00036
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB00223
constant: false
initial amount: NaN
is: CHEBI:16452
name: Oxaloacetate
initial concentration: 1.0

metaM ksi deg1 l
type: Species
is: CHEBI:18287
constant: false
is: HMDB00174
boundary condition: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_491fef62_d5c2_4ecf_9b25_4d6151732b19
is encoded by: hsa:9245
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: GCNT3
initial amount: NaN
is: O95395
constant: false

metaR ALAGLNexR
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
reversible: true
type: Reaction
kinetic law: MODEL1310110018#

metaM od2coa c
has only substance units: false
is: SBO:0000247
name: trans-Octadec-2-enoyl-CoA
is: CHEBI:50570
is: HMDB06529
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: C16218
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244

http://identifiers.org/biomodels.db/MODEL1310110018#_4d67930a_607a_4aa2_a57f_89b8ed4ecaec
is: Q6IBC0
has only substance units: false
boundary condition: true
is encoded by: hsa:3155
is: SBO:0000252
type: Species
name: HMGCL
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_d1dee734_b8ae_4448_a26b_a3d259b378d3
boundary condition: true
is encoded by: hsa:212
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: ALAS2
is: Q5JZF5
initial concentration: NaN
constant: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM no c
is: CHEBI:16480
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB03378
constant: false
is: SBO:0000247
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
initial amount: NaN

metaM ksii core2 deg3 l
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
boundary condition: false
has only substance units: false
is: HMDB00143
initial amount: NaN
constant: false
type: Species
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 3
is: SBO:0000247

metaM pacald c
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16424
initial concentration: 1.0
has only substance units: false
constant: false
name: phenylacetaldehyde
initial amount: NaN
is: HMDB06236
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601

metaM sgalside hs l
type: Species
is: HMDB00904
is: CHEBI:16349
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
name: sulfatide galactocerebroside
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR r0208
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.1
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction

metaR PPD2CSPp
type: Reaction
reactant: MODEL1310110018#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
name: PPD2CSPp
kinetic law: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000000

metaM HC01397 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_45ef99af_3cbd_42f0_8fb6_16fb381b9c49
is: SBO:0000252
constant: false
is: E9PB82
type: Species
boundary condition: true
initial amount: NaN
name: HSD17B4
has only substance units: false
is encoded by: hsa:3295
initial concentration: NaN

metaM thmmp c
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial amount: NaN
name: Thiamin monophosphate
is: HMDB02666
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: C01081
is: CHEBI:37575

metaM f1a l
type: Species
is: SBO:0000247
constant: false
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB02917
is: CHEBI:17151
has only substance units: false

metaR r0068
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
is version of: http://identifiers.org/ec-code/3.1.2.1
is: SBO:0000176
reversible: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is described by: ECO:0000000

metaR CYSGLYexR
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction
name: L-cysteine/glycine reversible exchanger
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaR NADtpu
name: NAD transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ffc80209_ee0f_41f1_ad52_01c616e3b5f4
is: P31937
boundary condition: true
name: HIBADH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11112
type: Species
initial amount: NaN
constant: false

metaR IDOAASE3ly
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: alpha-L-iduronidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76

metaM c12dc c
is: HMDB04047
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: dodecanedioyl carnitine
constant: false
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
initial concentration: 1.0
is: C14143

metaR TYRt
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110018#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: L-tyrosine transport
kinetic law: MODEL1310110018#

metaM phytcoa c
is: CHEBI:57391
name: phytanoyl-CoA(4-)
initial concentration: 1.0
is: HMDB01359
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaM CE2838 e
name: maltononaose
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C01936
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838

metaR AIRCr
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
modifier: MODEL1310110018#

metaR SPODM
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
reversible: false

metaR TDCHOLAte
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110018#
type: Reaction
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110018#_ddc59833_e95c_4b5f_a8e8_92dda0818521
constant: false
boundary condition: true
is: Q10471
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2590
name: GALNT2

metaM n2m2nm l
type: Species
name: n2m2nmasn (w/o peptide linkage)
initial amount: NaN
boundary condition: false
is: CHEBI:30825
is: HMDB00573
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false

metaR RE0935E
is described by: ECO:0000000
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0935
type: Reaction

metaR MANtg
product: MODEL1310110018#
type: Reaction
reversible: false
name: mannose efflux from Golgi apparatus
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM ksii core2 pre5 g
is: HMDB06552
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial concentration: 1.0
is: CHEBI:2504
has only substance units: false
type: Species
boundary condition: false
constant: false
name: keratan sulfate II biosynthesis, precursor 5
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_2e7c8f8d_d2d6_471c_96e7_d4990fbe675f
initial concentration: NaN
is encoded by: hsa:1737
is: SBO:0000297
boundary condition: true
has only substance units: false
has part: Q86YI5
constant: false
type: Species
initial amount: NaN
has part: P29803
has part: P11177
is encoded by: hsa:5161
name: DLAT:DLD:PDHA2:PDHB:PDHX
is encoded by: hsa:5162

metaM oxa m
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
has only substance units: false
is: HMDB02329
is: SBO:0000247
boundary condition: false
is: CHEBI:30623
name: oxalate(2-)
type: Species
initial amount: NaN

metaM ksi pre29 g
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28067
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 29
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_bce06771_2367_40c3_a38d_b532f8446aca
name: CHAT
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P28329
is encoded by: hsa:1103
constant: false
boundary condition: true

metaM gthrd e
boundary condition: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
is: SBO:0000247
initial amount: NaN
name: glutathionate(1-)
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57925

metaM pan4p e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:47942
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
boundary condition: false
type: Species
is: SBO:0000247
name: Pantetheine 4'-phosphate
is: C01134

http://identifiers.org/biomodels.db/MODEL1310110018#_e52dd1ee_ed34_44b5_a542_e174fee07b49
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: B1AM93
name: NDUFA8
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4702

metaR RE2814M
is described by: ECO:0000000
name: RE2814
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_cee04da8_5132_4e65_9778_2c1ac9460bc3
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AV717590_1_c
is encoded by: hsa:AV717590
constant: false
has only substance units: false
type: Species

metaM saccrp L m
is: HMDB00279
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
has only substance units: false
boundary condition: false
name: L-saccharopinate(1-)
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57951
is: SBO:0000247
constant: false

metaM pheme e
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
has only substance units: false
constant: false
is: C00032
is: HMDB03178
type: Species
initial concentration: 1.0
is: CHEBI:17627
boundary condition: false
name: Protoheme

http://identifiers.org/biomodels.db/MODEL1310110018#_ad315990_4132_45ca_9f6d_7ab9e0fbc2fe
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:5152
name: PDE9A
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2e8c0493_259b_4299_b9b9_929f0606c938
is encoded by: hsa:AI222095
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AI222095_1_m
has only substance units: false
constant: false

metaR GLCNACASE3ly
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110018#

metaR GLRASE
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
name: glucuronolactone reductase
fast: false

metaM uppg3 c
is: HMDB01086
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: Uroporphyrinogen III
constant: false
is: CHEBI:57308
is: C01051
initial amount: NaN

metaR HSD3A1r
product: MODEL1310110018#
is described by: ECO:0000269
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

metaM bildglcur c
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: HMDB03325
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
type: Species
has only substance units: false

metaR CYTK7n
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_fb114f7c_420d_4bc3_92ae_d788e3ed33d4
initial amount: NaN
has only substance units: false
is: Q5JPH6
type: Species
is encoded by: hsa:124454
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: EARS2

http://identifiers.org/biomodels.db/MODEL1310110018#_f3141cf6_f4f1_4071_856a_77ecad773c04
initial concentration: NaN
constant: false
type: Species
name: PFAS
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5198
is: Q6P4B4
is: SBO:0000252

metaM for e
boundary condition: false
has only substance units: false
name: formate
is: SBO:0000247
type: Species
is: HMDB00142
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
initial concentration: 1.0
initial amount: NaN

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: CHEBI:17544
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: Bicarbonate
is: HMDB00595
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_df4031fe_9789_4243_80e9_570109d2d475
is encoded by: hsa:765
constant: false
boundary condition: true
initial amount: NaN
name: CA6
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q5FC00

metaM em2emgacpail prot hs r
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16870
is: HMDB00086
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0

metaM leu L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-leucine
constant: false
has only substance units: false
is: CHEBI:15603
initial amount: NaN
is: HMDB00687
type: Species

metaR ALAGLYexR
is described by: ECO:0000304
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
fast: false
name: L-alanine/glycine reversible exchange
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8bffbde1_69d8_4b5e_ab61_641ce8ef4711
is: SBO:0000252
name: NME1
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110018#_829106c8_d42a_480f_b70c_04245d084caf
is encoded by: hsa:3948
name: LDHC
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P07864
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_02d59a23_4495_4021_9c65_e2454ac76f1e
initial amount: NaN
name: PLCXD2
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q0VAA5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:257068

metaR DCSPTN1t
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#

metaM lneldccoa m
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB01064
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
constant: false
name: linoelaidyl coenzyme A

metaM r5p c
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00618
is: C00117
initial amount: NaN
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
has only substance units: false

metaR RE1709N
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true

metaR CSNt
kinetic law: MODEL1310110018#
name: cytosine transport via facilated diffusion
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_3eee61c2_e18f_451e_8741_9687a517e1b1
boundary condition: true
name: _NOS2A_1_c
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:NOS2A
has only substance units: false
is: SBO:0000252

metaM gthrd c
has only substance units: false
type: Species
is: HMDB00125
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
name: Reduced glutathione
is: C00051
boundary condition: false
constant: false
is: CHEBI:57925

metaM 5adtststerone e
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
has only substance units: false
is: CHEBI:16330
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM pan4p c
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
boundary condition: false
is: CHEBI:47942
is: HMDB01416
is: SBO:0000247
constant: false
name: Pantetheine 4'-phosphate
initial concentration: 1.0
type: Species
is: C01134

metaR S6TASE3ly
is described by: ECO:0000000
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110018#
is: SBO:0000176

metaM pheme c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00032
type: Species
constant: false
is: HMDB03178
initial concentration: 1.0
boundary condition: false
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
name: Protoheme

metaR RE0691C
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
name: RE0691
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_0cdcc0a3_f6a8_46ea_b42d_fc40aa8d4bdd
type: Species
is: SBO:0000252
name: COX8A
is: Q53XN1
constant: false
is encoded by: hsa:1351
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_8cfac89a_4f7d_4f27_9f90_cd6f482bfefe
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _AI915649_1_c
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI915649

metaR S6T16g
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM for c
initial amount: NaN
name: Formate
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
is: HMDB00142
constant: false
is: C00058
initial concentration: 1.0
has only substance units: false
is: CHEBI:15740
boundary condition: false

metaR r0926
kinetic law: MODEL1310110018#
type: Reaction
reversible: false
name: Postulated transport reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR DCK1n
name: Deoxycytidine kinase, nuclear (ATP)
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is described by: ECO:0000269
reversible: true
product: MODEL1310110018#

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM 5adtststerone c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16330
type: Species

metaR S6TASE25ly
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM dcsptn1coa c
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06513
constant: false
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
is: C16173
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_59b1f3bf_78e3_4bb7_b4eb_d8acb578d881
initial amount: NaN
is: SBO:0000252
constant: false
name: APRT
is encoded by: hsa:353
type: Species
has only substance units: false
is: P07741
boundary condition: true
initial concentration: NaN

metaR LEUtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000269
product: MODEL1310110018#
name: L-leucine transport via diffusion (extracellular to cytosol)
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_f9f9e763_1de0_40bf_931c_2ff48111ba4f
name: ENTPD2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9Y5L3
constant: false
boundary condition: true
type: Species
is encoded by: hsa:954
has only substance units: false

metaM txa2 r
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
is: CHEBI:57445
initial amount: NaN
has only substance units: false
is: HMDB01452
initial concentration: 1.0
name: thromboxane A2(1-)
constant: false

metaR ACETONEt2
reactant: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: acetone transport via proton symport
modifier: MODEL1310110018#
is: SBO:0000185

metaR MALTe
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: alpha-glucosidase, extracellular
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reversible: false
type: Reaction
is: SBO:0000176
fast: false

metaR r2435
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM crn e
is: SBO:0000247
constant: false
is: C00318
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
initial concentration: 1.0
name: L-Carnitine
is: CHEBI:16347
initial amount: NaN
is: HMDB00062
has only substance units: false

metaM CE1926 e
initial amount: NaN
is: CHEBI:15748
has only substance units: false
is: HMDB00127
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

metaR PHEMEt
name: heme transport
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: false

metaR PI45P3K
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
reversible: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
product: MODEL1310110018#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase

http://identifiers.org/biomodels.db/MODEL1310110018#_9126e35b_5812_41ae_9c67_374bb18114af
has only substance units: false
is encoded by: hsa:6487
constant: false
initial amount: NaN
name: ST3GAL3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q5T4W8
type: Species

metaR r1597
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_362bab36_8167_4f16_bec5_025ff685e57d
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: B3KTV4
name: ADSSL1
initial concentration: NaN
is encoded by: hsa:122622
type: Species
has only substance units: false

metaR RE2814R
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110018#
fast: false
is: SBO:0000176
type: Reaction
name: RE2814

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: CHEBI:203600
initial concentration: 1.0
has only substance units: false
is: HMDB01498
constant: false

metaR r0651
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_912b066f_9c0c_4fdb_878f_be8d8be777b3
is encoded by: hsa:84649
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: Q96PD7
has only substance units: false
name: DGAT2

http://identifiers.org/biomodels.db/MODEL1310110018#_5bdf0e18_0f62_4152_8846_07c9f38abc16
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: P51648
is encoded by: hsa:224
has only substance units: false
name: ALDH3A2

metaR O2ter
reversible: true
name: O2 transport, endoplasmic reticulum
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM h2o2 x
is: SBO:0000247
is: CHEBI:16240
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
constant: false
boundary condition: false
initial amount: NaN
name: Hydrogen peroxide
is: C00027

http://identifiers.org/biomodels.db/MODEL1310110018#_fbde5468_eb4c_4814_a123_2a85f766084d
has only substance units: false
constant: false
name: SHMT1
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6470
initial concentration: NaN

metaR CORE4GTg
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_ddc591cc_e6d2_4734_8320_56de4c81cb67
type: Species
name: ALOX5
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P09917
is encoded by: hsa:240
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_3c80dcd7_60af_4e74_bd68_f751e2b4ed55
is: E9PB82
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HSD17B4
is: SBO:0000252
constant: false
is encoded by: hsa:3295
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_245a8f50_8839_45d3_ab2a_21852005bae6
type: Species
is: SBO:0000252
is: Q9Y6T7
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: DGKB
is encoded by: hsa:1607
initial concentration: NaN

metaR M13N2Tg
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.101
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
product: MODEL1310110018#
reversible: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaR r0650
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR H2O2tn
fast: false
name: hydrogen peroxide nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
product: MODEL1310110018#

metaM 10fthf5glu e
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00108
name: 10-formyltetrahydrofolate-[Glu](5)
has only substance units: false
is: CHEBI:16236

metaR r1598
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
fast: false
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_38e908e8_4233_4474_a144_232cae24c3bf
name: _AI222095_1_e
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI222095
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_f40e7cc6_6e90_4d01_8dd3_1e4ac14960a7
is: SBO:0000252
constant: false
is encoded by: hsa:AV717590
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: _AV717590_1_m
has only substance units: false

metaM hexdectecoa m
is: SBO:0000247
is: HMDB02288
constant: false
has only substance units: false
type: Species
name: 2,4,7,10-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR PSDm hs
fast: false
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176

metaM 3aib e
type: Species
boundary condition: false
name: (S)-3-aminoisobutyric acid
is: HMDB02166
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaM r5p r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
constant: false
is: HMDB00618
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaM hco3 c
is: CHEBI:17544
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
initial amount: NaN
is: HMDB00595
is: C00288
name: Bicarbonate
constant: false
initial concentration: 1.0

metaR HSAT3ly
is: SBO:0000185
reactant: MODEL1310110018#
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false

metaM ksi deg1 e
is: SBO:0000247
is: HMDB00211
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17268
initial amount: NaN
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7264b920_b94d_4012_ba84_197bc93278c5
has only substance units: false
constant: false
is encoded by: hsa:376497
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SLC27A1

metaR 3SALAOX
product: MODEL1310110018#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
name: cysteinesulfinic acid oxidase
is described by: ECO:0000000
kinetic law: MODEL1310110018#
type: Reaction

metaR r0653
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is described by: ECO:0000000
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false

metaR r1446
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR r1599
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110018#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_91b26d54_3ce1_4082_baf0_f93a7871605a
type: Species
initial amount: NaN
boundary condition: true
is: P05091
is encoded by: hsa:217
constant: false
name: ALDH2
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR HS1ly
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110018#
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110018#_c2029380_eb83_4635_99f5_756bfb85b39e
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q9H3H5
is encoded by: hsa:1798
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: DPAGT1

metaM hs deg18 l
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01352
boundary condition: false
constant: false
is: CHEBI:17180
name: heparan sulfate, degradation product 18
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_b5374157_e27f_4d15_aa7f_40a209c1d48d
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q9NRF8
name: CTPS2
is encoded by: hsa:56474
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_6be76e24_1edc_46bc_bce7_591fa749a7e7
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_e

metaR H2O2tp
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
name: hydrogen peroxide peroxisomal transport via diffusion
product: MODEL1310110018#

metaR SPMTDe
product: MODEL1310110018#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000134
name: SPMTDe

metaM lneldccoa c
constant: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB06521
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: linoelaidyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677

metaR GLCNACPT U
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.15
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_7a5fc801_7448_468d_a6cf_9f34aecb280b
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _R14373_1_x
is encoded by: hsa:R14373
constant: false

metaR r0652
is described by: ECO:0000000
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction

metaM oaa m
type: Species
initial amount: NaN
name: Oxaloacetate
is: C00036
is: HMDB00223
is: CHEBI:16452
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

metaR COt
reactant: MODEL1310110018#
name: CO transporter via diffusion
reversible: true
product: MODEL1310110018#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000

metaM gthrd m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
name: glutathionate(1-)
is: HMDB00125
is: CHEBI:57925
has only substance units: false

metaR PHACCOAGLNAC
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110018#

metaM thmmp m
is: HMDB02666
is: SBO:0000247
is: CHEBI:37575
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
name: thiamine(1+) monophosphate(2-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM crn r
constant: false
is: HMDB00062
type: Species
name: (R)-carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16347
initial amount: NaN

metaR SUCCtp
reversible: true
name: succinate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR LNELDCCPT2
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110018#
is: SBO:0000176
reversible: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ed84bc1d_40fe_4904_b16e_d7283841024a
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AA788780_1_c
constant: false
is encoded by: hsa:AA788780
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_334ff60c_1650_48f4_a94d_5a350a548d59
constant: false
boundary condition: true
is: P48448
initial amount: NaN
type: Species
is encoded by: hsa:222
has only substance units: false
is: SBO:0000252
name: ALDH3B2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_370e7da2_c20d_4eec_8b35_7d2f43992628
initial amount: NaN
name: PRDX2
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7001

metaM 3aib c
is: HMDB02166
name: (S)-3-aminoisobutyric acid
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:33094
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial amount: NaN
has only substance units: false

metaR CYTK1
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP)
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#

metaM cs a l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
is: HMDB02183
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: SBO:0000247
initial amount: NaN
is: CHEBI:36005

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_4c73754c_d6cf_4aad_a933_0aab625bcaad
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r1593
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM leu L c
initial amount: NaN
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00687
type: Species
boundary condition: false

metaM HC01522 c
boundary condition: false
is: CHEBI:28508
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: Gentisate aldehyde
initial concentration: 1.0

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110018#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM CE5160 r
constant: false
name: 3-oxo-cis-9-octadecenoyl-CoA
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57923
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_bd781687_cd8d_49e0_b27a_e0603b4fb470
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: RRM2
is: SBO:0000252
is encoded by: hsa:6241
initial amount: NaN
is: P31350

metaR PRO1xm
product: MODEL1310110018#
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
name: proline oxidase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110018#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_17819daa_de14_4093_b3df_239c83eb49af
has only substance units: false
is: SBO:0000252
is: Q53YE7
is encoded by: hsa:4128
name: MAOA
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM pheme m
initial concentration: 1.0
initial amount: NaN
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
constant: false
is: C00032
is: CHEBI:17627
name: Protoheme
type: Species
is: SBO:0000247
boundary condition: false

metaR FAOXC225C204m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR P4501B1r
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110018#
is described by: ECO:0000269
fast: false
product: MODEL1310110018#
is: SBO:0000176
name: cytochrome P450 1B1
kinetic law: MODEL1310110018#
reversible: false
type: Reaction
modifier: MODEL1310110018#

metaR r0317
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110018#_3aea3918_baca_4874_a57b_a237e4b3a37d
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5831
constant: false
name: PYCR1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: A6NFM2

metaR r1594
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#

metaM orn m
type: Species
constant: false
initial amount: NaN
is: C01602
is: SBO:0000247
has only substance units: false
name: Ornithine
boundary condition: false
initial concentration: 1.0
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110018#_ad4d1520_10b5_4b21_b882_1c1ee1e8efe9
is: O15427
constant: false
name: SLC16A3
is encoded by: hsa:9123
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM ca2 c
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:29108
initial concentration: 1.0
name: calcium(2+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_8582d022_21a7_4a61_9251_d0023845b673
name: GCNT1
is: SBO:0000252
has only substance units: false
is: Q02742
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2650
initial concentration: NaN

metaR ADNCYC
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
name: adenylate cyclase
product: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/4.6.1.1
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_5e75e49e_be04_4a76_89a1_1d03d857aa19
is encoded by: hsa:6534
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC6A7
is: SBO:0000252
boundary condition: true
is: Q99884

metaR A4GNT2g
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
reversible: false
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_aa4447e0_8cf9_4dbd_828a_80bffcaaca14
is encoded by: hsa:205
constant: false
is: SBO:0000252
initial amount: NaN
is: P27144
has only substance units: false
type: Species
name: AK4
initial concentration: NaN
boundary condition: true

metaM leu L e
boundary condition: false
is: CHEBI:15603
is: SBO:0000247
name: L-leucine
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaR r1595
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_1a055603_0217_4b6d_8a47_875d84d4a381
name: _PRO1933_1_m
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:PRO1933
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_113adb12_1e81_49d3_aba4_ddcda409a795
is encoded by: hsa:6567
is: P36021
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: SLC16A2
initial concentration: NaN
has only substance units: false

metaM HC01397 x
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial amount: NaN
is: SBO:0000247
is: CHEBI:27402
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_4639d0fc_f69e_4f1d_9c1a_36301660e004
is encoded by: hsa:10870
has part: Q9UBK5
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:5294
name: HCST:PIK3CG
constant: false
has part: P48736
initial amount: NaN

metaM trdox m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191

metaM crn m
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16347
is: C00318
is: HMDB00062
has only substance units: false
constant: false
boundary condition: false
name: L-Carnitine

metaR r1596
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_30310efa_1048_47ea_82f5_40df4059f275
type: Species
name: UPP2
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:151531
has only substance units: false
boundary condition: true
is: O95045

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
modifier: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110018#

metaR RE1709C
reactant: MODEL1310110018#
product: MODEL1310110018#
name: RE1709
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000176

metaM ala L c
type: Species
initial amount: NaN
is: CHEBI:16977
boundary condition: false
constant: false
initial concentration: 1.0
name: L-alanine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
has only substance units: false

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110018#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR GTMLTe
kinetic law: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000185
name: g-glutamyltransferase (e)
reversible: false
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110018#_810ca1fc_8e87_446a_82c1_90817ecaf3cf
is encoded by: hsa:1178
has only substance units: false
initial amount: NaN
is: C5HZ13
boundary condition: true
constant: false
is: SBO:0000252
name: CLC
initial concentration: NaN
type: Species

metaM nadp x
is: C00006
boundary condition: false
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00217
is: SBO:0000247

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM akg x
boundary condition: false
is: HMDB00208
name: 2-oxoglutarate(2-)
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810

metaM tetpent6coa x
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
is: C16172

http://identifiers.org/biomodels.db/MODEL1310110018#_2508e81c_331e_46fd_8559_7e9738e88b65
initial amount: NaN
is: SBO:0000252
is: O14772
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:8790
name: FPGT

http://identifiers.org/biomodels.db/MODEL1310110018#_63570590_c50e_496b_b2fa_112a89ca4e88
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: OGDH
is: B4E3E9
is encoded by: hsa:4967

metaM thr L e
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00167
name: L-threonine
constant: false
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false

metaR G14T15g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110018#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
fast: false
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000

metaR CSND
name: Cytosine deaminase
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
is: SBO:0000176
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000

metaM ksi pre15 g
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
boundary condition: false
is: CHEBI:2504
is: SBO:0000247
is: HMDB06552
name: keratan sulfate I biosynthesis, precursor 15
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_1b6dc87c_a6b1_4684_b3c1_01ba7c22bc7c
type: Species
is: SBO:0000252
constant: false
name: MCEE
is: Q96PE7
is encoded by: hsa:84693
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0633
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110018#
type: Reaction
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_26904da6_e3cc_49ef_b49b_873b133f0712
name: GALNT14
boundary condition: true
is: SBO:0000252
constant: false
is: Q96FL9
is encoded by: hsa:79623
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM pchol hs c
boundary condition: false
constant: false
name: Phosphatidylcholine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
type: Species

metaR PMTCOAtx
fast: false
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true

metaM onpthl e
boundary condition: false
name: naphthalene epoxide
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
constant: false
is: HMDB06215
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM ile L c
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: L-isoleucine
type: Species
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17191

metaM tchola x
is: HMDB00036
name: taurocholate
is: CHEBI:36257
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_ad04d8ee_6248_4693_a6be_45cca5178d0f
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: AADAT
is: Q4W5N8
is encoded by: hsa:51166
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d85ea73d_4e01_4afb_9424_8b473804883a
initial concentration: NaN
constant: false
name: _R51273_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:R51273
initial amount: NaN
type: Species

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r0630
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_23d2f25d_34bf_4978_a59f_074f8bb26fc2
constant: false
is: SBO:0000252
is: B4DX62
type: Species
boundary condition: true
name: ST3GAL3
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_52b8f3b1_3fc8_44bb_bd8b_a1689c59c762
name: NDUFV3
is encoded by: hsa:4731
initial concentration: NaN
is: P56181
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR DGCHOLtx
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b7874175_5c50_4827_ada1_aeded86f13b8
initial concentration: NaN
type: Species
boundary condition: true
has part: Q9P2X0
initial amount: NaN
is encoded by: hsa:54344
has only substance units: false
name: DPM3:DPM1:DPM2
constant: false
is: SBO:0000297
is encoded by: hsa:8818

http://identifiers.org/biomodels.db/MODEL1310110018#_3ee3b24b_4cc7_412a_939a_1df79a335b1b
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: Q99798
is encoded by: hsa:50
name: ACO2
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c3cf1319_58fd_40ee_a2e1_7a7c2e2afea4
type: Species
is encoded by: hsa:57835
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9BY07
name: SLC4A5

metaM bildglcur r
boundary condition: false
is: CHEBI:58471
initial amount: NaN
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247
has only substance units: false
is: HMDB03325
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2fc6bb4c_7dd7_44a8_a984_bac9f742d5f3
boundary condition: true
type: Species
is encoded by: hsa:4538
has only substance units: false
initial concentration: NaN
is: P03905
constant: false
initial amount: NaN
is: SBO:0000252
name: ND4

http://identifiers.org/biomodels.db/MODEL1310110018#_b6a38c17_a1b2_4f13_8ea8_1ea5390a4e94
is encoded by: hsa:124637
name: CYB5D1
initial concentration: NaN
is: Q6P9G0
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaM pail5p hs n
constant: false
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_ea878519_e8e3_4117_a687_3b1bc4f2b34b
name: NDUFS1
is encoded by: hsa:4719
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: P28331
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR 4MOPte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of 4-methyl-2-oxopentanoate
kinetic law: MODEL1310110018#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_35003ea3_5ca9_4697_8d16_783b0c008a39
type: Species
has only substance units: false
is: Q9GZR5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ELOVL4
is encoded by: hsa:6785
initial amount: NaN
constant: false

metaR GASNASE3ly
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_4d49a71c_d6c1_4331_9e70_183b7f246f4a
has only substance units: false
name: GALNT9
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q9HCQ5
is encoded by: hsa:50614

metaR C12DCe
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C12DC
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c098bb50_2452_458a_9aa8_c77159dcc945
initial concentration: NaN
is: Q15392
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1718
is: SBO:0000252
name: DHCR24
initial amount: NaN
has only substance units: false

metaM pchol hs e
is: CHEBI:16110
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
initial amount: NaN
name: Phosphatidylcholine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pristcoa c
is: CHEBI:51341
name: pristanoyl coa
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247

metaM ile L e
constant: false
is: CHEBI:17191
is: SBO:0000247
name: L-isoleucine
boundary condition: false
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
initial amount: NaN
is: HMDB11111
has only substance units: false
type: Species
name: 3-oxopropanoate
initial concentration: 1.0
is: CHEBI:33190
is: SBO:0000247
constant: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a5a30fbd_6783_4673_9263_3c1f1f0b35cb
has only substance units: false
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_66cebc05_6e69_4a24_8855_9fddcae3758e
is: SBO:0000252
is: B7Z6S1
has only substance units: false
type: Species
is encoded by: hsa:2629
initial amount: NaN
name: GBA
boundary condition: true
constant: false
initial concentration: NaN

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR UPP3S
type: Reaction
is: SBO:0000176
fast: false
name: uroporphyrinogen-III synthase
is version of: http://identifiers.org/ec-code/4.2.1.75
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_f48771de_6eb4_4fc3_b7af_a1fd20b5bc8e
boundary condition: true
type: Species
name: ACSL3
initial concentration: NaN
is: B3KMA6
is encoded by: hsa:2181
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR S26Tg
type: Reaction
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110018#
name: beta-galactoside alpha-2,6-sialyltransferase
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.99.1
reactant: MODEL1310110018#

metaM dolmanp U r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15809
is: SBO:0000247
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
constant: false
type: Species

metaR GALASE20ly
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: beta-galactosidase, lysosomal
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000

metaM orot e
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00226
name: orotate
initial concentration: 1.0
is: CHEBI:30839
constant: false
boundary condition: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM hs deg22 l
notes: FORMULA: C37H56NO35S CHARGE: -3
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:21338
is: HMDB02704
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_de56e147_1b22_4909_beb8_6a24425607de
type: Species
name: ACAA1
initial amount: NaN
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaM i c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16382
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: iodide
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

http://identifiers.org/biomodels.db/MODEL1310110018#_7e82e8ae_62df_4812_b285_f23a77f277ab
initial amount: NaN
is encoded by: hsa:5313
initial concentration: NaN
boundary condition: true
name: PKLR
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: P30613

http://identifiers.org/biomodels.db/MODEL1310110018#_52410253_b0a1_4324_a9b8_a3838added61
initial amount: NaN
is encoded by: hsa:6536
constant: false
is: SBO:0000252
name: SLC6A9
initial concentration: NaN
type: Species
boundary condition: true
is: B7Z3W8
has only substance units: false

metaR SACCD4m
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.8
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
modifier: MODEL1310110018#
is: SBO:0000176
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
reversible: false
product: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
fast: false

metaR FAOXC122C101m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM prostgh2 r
is: CHEBI:57405
is: HMDB01381
constant: false
name: prostaglandin H2(1-)
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_537995a0_9d8f_4375_9af3_2691f0494f36
is encoded by: hsa:5106
initial concentration: NaN
constant: false
is: Q16822
is: SBO:0000252
name: PCK2
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_83cf0f33_2b0e_4fe6_ba44_1560684fed01
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:23632
has only substance units: false
boundary condition: true
name: CA14
initial amount: NaN
initial concentration: NaN
is: A8K3J4

metaR C226COAtx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
fast: false

metaR Coqe
type: Reaction
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000134
name: Transport of q10
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR RE2666C
reactant: MODEL1310110018#
is: SBO:0000176
name: RE2666
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false

metaM ala L e
is: CHEBI:16977
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB00161
name: L-alanine
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaM nadp r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58349
is: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
constant: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_54459f2a_0bc5_443c_8d28_72e6247c59f6
name: ARG2
type: Species
boundary condition: true
is encoded by: hsa:384
has only substance units: false
initial concentration: NaN
is: P78540
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_3e0dbe20_d9b2_4e37_b772_bcd6f0fa5d0a
type: Species
name: DHFR
initial concentration: NaN
is encoded by: hsa:1719
is: P00374
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_061ef6e5_a340_413a_b0bf_a3865af6ad60
initial concentration: NaN
has only substance units: false
is: P14060
name: HSD3B1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3283
initial amount: NaN

metaR r0634
is: SBO:0000176
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1

http://identifiers.org/biomodels.db/MODEL1310110018#_6b71ac93_8194_4ec3_bb14_c2170fa6efb9
initial amount: NaN
has only substance units: false
is encoded by: hsa:5137
type: Species
is: Q8NB10
constant: false
is: SBO:0000252
name: PDE1C
boundary condition: true
initial concentration: NaN

metaR CYStec
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000185
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
name: L-cysteine transport via diffusion (extracellular to cytosol)

metaR RE3301C
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
name: RE3301
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_5bde076f_130e_4c60_b4f6_733f0b4113af
boundary condition: true
name: MAN1B1
type: Species
is: Q9UKM7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:11253
initial amount: NaN
is: SBO:0000252

metaR SFGTH
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.12
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
name: S-Formylglutathione hydralase
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110018#

metaR DOLPH Uer
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
reversible: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
kinetic law: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:

metaM xol7ah2 c
is: CHEBI:28047
is: HMDB06893
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ac0c3f0a_5fce_4950_9d24_850df11d3d17
has only substance units: false
is encoded by: hsa:2954
initial concentration: NaN
name: GSTZ1
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaM orot c
type: Species
is: SBO:0000247
name: Orotate
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
is: CHEBI:30839
constant: false
initial amount: NaN
is: HMDB00226
initial concentration: 1.0
is: C00295

metaM dd2coa m
is: HMDB03712
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57330
is: SBO:0000247

metaR SPHINGStl
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110018#
name: sphingosine intracellular transport
product: MODEL1310110018#
is: SBO:0000185

metaM i e
type: Species
name: iodide
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB12238
has only substance units: false
is: SBO:0000247

metaR ADSK
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: adenylyl-sulfate kinase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_09bc11b5_3ca6_4167_ab25_adc94d901f89
has only substance units: false
is: P09669
name: COX6C
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1345

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM thr L c
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16857
initial amount: NaN
name: L-threonine

http://identifiers.org/biomodels.db/MODEL1310110018#_e92f8ed4_973b_4099_bc61_3b8855632978
is: SBO:0000252
name: SLC16A7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9194
type: Species
constant: false
boundary condition: true
is: Q8NEM3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ca5ba332_19b1_40d6_8142_027afd61580c
is encoded by: hsa:160851
has only substance units: false
is: A8K0I1
constant: false
name: DGKH
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_25114f5e_dc45_422d_b6ce_90235767c1bc
is: P51688
initial amount: NaN
is encoded by: hsa:6448
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SGSH

metaM melatn c
boundary condition: false
is: HMDB01389
has only substance units: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
name: melatonin
is: CHEBI:16796
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR DURAD
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrouracil dehydrogenase (NADP)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_73202bc5_32dc_48f4_9efb_82881fa205e6
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:115286
constant: false
name: SLC25A26

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2aa56824_be06_4097_8aa7_b8db527fdb03
is: SBO:0000252
is: P30825
constant: false
initial amount: NaN
name: SLC7A1
initial concentration: NaN
is encoded by: hsa:6541
has only substance units: false
boundary condition: true
type: Species

metaM 2octpencoa m
name: 2,6,9,12,15-octadecapentenoylcoa
boundary condition: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
constant: false
type: Species
initial concentration: 1.0

metaM for r
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
name: Formate
initial concentration: 1.0
is: C00058
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00142
is: CHEBI:15740
is: SBO:0000247

metaM onpthl c
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: naphthalene epoxide
is: HMDB06215
initial concentration: 1.0
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_bc738730_c13c_4851_87bb_b3edf4131ca7
has only substance units: false
boundary condition: true
initial amount: NaN
name: PEMT
type: Species
constant: false
is encoded by: hsa:10400
initial concentration: NaN
is: SBO:0000252

metaR RE2677C
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
is: SBO:0000176

metaR PPNCL3
type: Reaction
reversible: false
reactant: MODEL1310110018#
name: phosphopantothenate-cysteine ligase
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaR AG13T10g
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110018#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c796f325_cde4_4a28_a2fc_85e67a06558f
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5338
is: O14939
name: PLD2
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_552ea767_f1e7_4ec5_aeea_c225efd4d638
name: ADH5
is: Q6IRT1
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:128
constant: false
initial concentration: NaN
initial amount: NaN

metaR ADMDC
kinetic law: MODEL1310110018#
fast: false
name: adenosylmethionine decarboxylase
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.1.1.50
reversible: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_9377e8e4_2e2f_4c77_b627_7e374929cc67
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFB6
initial amount: NaN
is: Q5VYT2
has only substance units: false
is encoded by: hsa:4712

metaR r0202
is: SBO:0000176
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
product: MODEL1310110018#

metaR r2009
fast: false
modifier: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_7ec901b7_aefc_4b54_867e_3b7bf01dd184
initial amount: NaN
type: Species
boundary condition: true
is: O95169
constant: false
initial concentration: NaN
is encoded by: hsa:4714
name: NDUFB8
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_6aaa51d1_b63a_485d_be0f_865a25a11a23
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA419122
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: _AA419122_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3a924254_3746_407b_9878_fa13fd58bd6a
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: _AI539321_1_c
is encoded by: hsa:AI539321

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM ditp c
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:61382
has only substance units: false
name: dITP(4-)
is: HMDB03537
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_a2a2fe64_e4c1_475c_97e0_1ba2d0c709d6
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10935
is: SBO:0000252
boundary condition: true
name: PRDX3
is: P30048
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2e718fc7_4dd5_443b_b3b1_b6ddfcfbdc2b
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _U37519_1_c
is encoded by: hsa:U37519
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reversible: true
is described by: ECO:0000000
fast: false

metaM ins c
is: CHEBI:17596
is: C00294
name: Inosine
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
boundary condition: false
is: HMDB00195
is: SBO:0000247

metaR r0638
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2
is described by: ECO:0000000

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
is: HMDB00217
is: CHEBI:58349
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: C00006
name: Nicotinamide adenine dinucleotide phosphate

metaR ASAH1
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.1.23
reversible: false
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: N-acylsphingosine amidohydrolase
reactant: MODEL1310110018#
fast: false

metaM akg m
type: Species
name: 2-Oxoglutarate
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
is: CHEBI:16810
is: HMDB00208
is: C00026
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM tettet6coa x
is: HMDB06516
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: tetracosatetraenoyl coenzyme A
type: Species
is: C16171
is: http://identifiers.org/pubchem.compound/47205481
has only substance units: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e096f0fd_a624_4650_a982_77edd46812e9
constant: false
type: Species
initial amount: NaN
name: HIBCH
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26275
has only substance units: false
is: Q6NVY1

metaM adprbp e
initial concentration: 1.0
is: CHEBI:58673
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
is: HMDB06336
name: ADP-D-ribose 2'-phosphate(4-)
initial amount: NaN

metaR HSAT4ly
product: MODEL1310110018#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110018#
is: SBO:0000185

metaM andrstrn r
has only substance units: false
is: CHEBI:16032
initial concentration: 1.0
name: androsterone
boundary condition: false
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial amount: NaN
is: HMDB00031
is: SBO:0000247
constant: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR r0639
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
fast: false

metaM ile L m
name: L-isoleucine
is: CHEBI:17191
is: SBO:0000247
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00172
constant: false

metaM c12dc e
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: C14143
initial concentration: 1.0
boundary condition: false
name: dodecanedioyl carnitine
is: HMDB04047
notes: FORMULA: C19H34NO6 CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_937212ef_7bdb_4ade_ad9b_b7e8acf31da7
is: SBO:0000252
constant: false
name: CHST1
is: O43916
initial amount: NaN
type: Species
is encoded by: hsa:8534
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_aee38599_bf3e_4398_95e3_537cd807f03c
initial concentration: NaN
initial amount: NaN
name: PYCR2
boundary condition: true
is: Q96C36
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:29920

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR EX coumarin LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: coumarin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_8d9cdb12_d519_484d_9bdd_cc9ca2ca6082
initial concentration: NaN
type: Species
boundary condition: true
is: O60760
is encoded by: hsa:27306
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: HPGDS

metaR ENGASEly
reversible: false
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110018#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176

metaR 3HBCOAHLm
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_bd05a360_72e9_48f4_8056_5aed901c91a4
is encoded by: hsa:3423
constant: false
initial concentration: NaN
name: IDS
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: P22304
initial amount: NaN

metaR RE1521M
reactant: MODEL1310110018#
fast: false
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1521
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM gua c
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine
type: Species
is: HMDB00132
has only substance units: false
is: C00242
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16235

metaR AHCYSte
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110018#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR DURItn
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: deoxyuridine transport in nucleus
is: SBO:0000185
kinetic law: MODEL1310110018#

metaR HEXDICOAACBPx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR NORANMT
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.1.28
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
fast: false
name: noradrenaline N-methyltransferase

metaR ALACYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110018#
reversible: false
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000185
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
type: Reaction
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#

metaM hs deg19 l
is: SBO:0000247
has only substance units: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 19
is: HMDB01352

metaR r0789
modifier: MODEL1310110018#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM pro D c
name: D-proline
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: HMDB03411
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16313
initial concentration: 1.0

metaR r0074
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_baade04c_ab94_4abd_863a_20fdb1d6a9ef
is: P55084
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: HADHB
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:3032

metaR AHCYStd
is: SBO:0000185
name: diffusion of S-Adenosyl-L-homocysteine
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_f394e7be_726a_4b62_a034_b4a1e41221ba
is: Q14032
constant: false
type: Species
name: BAAT
initial concentration: NaN
boundary condition: true
is encoded by: hsa:570
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM ksi pre6 g
name: keratan sulfate I biosynthesis, precursor 6
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06552
has only substance units: false
is: CHEBI:2504
notes: FORMULA: C107H174N7O80SX CHARGE: -2
type: Species
initial amount: NaN

metaR ESTRADIOLtr
is: SBO:0000185
fast: false
reactant: MODEL1310110018#
name: estradiol intracellular transport
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_efce0110_4943_4111_afc4_85d7e034f696
constant: false
name: SLC13A5
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q86YT5
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:284111

metaR PDX5PO
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
name: pyridoxine 5'-phosphate oxidase
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#

metaM bildglcur e
is: HMDB03325
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58471
initial amount: NaN
constant: false

metaM ppp9 m
boundary condition: false
constant: false
is: HMDB00241
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Protoporphyrin
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: CHEBI:36159
type: Species
initial concentration: 1.0

metaR GALASE16ly
reactant: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
name: beta-galactosidase, lysosomal
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_e1af0e27_e497_4bc7_8126_69a3139a4b96
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5151
boundary condition: true
is: H0YMZ7
name: PDE8A
constant: false
is: SBO:0000252

metaM c12dccoa x
is: SBO:0000247
name: dodecanedioylcoa
has only substance units: false
type: Species
is: C14143
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: HMDB04047
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_1e498de6_a5d4_4d37_ac8a_c75aa62050f6
is encoded by: hsa:AI934540
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AI934540_1_c

metaR ADSS
kinetic law: MODEL1310110018#
is described by: ECO:0000134
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.4
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
fast: false
product: MODEL1310110018#
name: adenylosuccinate synthase
is: SBO:0000176

metaR EX aflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: aflatoxin B1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_bbd07465_7221_43a6_910d_179cc0d242d5
constant: false
name: SLC25A19
initial concentration: NaN
is encoded by: hsa:60386
boundary condition: true
initial amount: NaN
is: Q9HC21
is: SBO:0000252
has only substance units: false
type: Species

metaM galgbside hs g
is: SBO:0000247
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
boundary condition: false
name: galactosylgloboside
constant: false
is: CHEBI:18259
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_0c40e708_3de5_4010_b6cd_f822d729fdc3
is: O43570
initial concentration: NaN
name: CA12
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:771
has only substance units: false

metaR DCSPTN1CRNt
type: Reaction
reactant: MODEL1310110018#
fast: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reversible: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR r0787
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.1
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
is: SBO:0000176
modifier: MODEL1310110018#
reversible: false

metaM pro D e
initial concentration: 1.0
is: SBO:0000247
constant: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16313
boundary condition: false

metaR OROTGLUt
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
name: OROTGLUt
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_551221cb_23a5_48ef_bf76_acc611384976
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3707
is: P27987
name: ITPKB
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_700db77d_56a5_4505_a5bc_e4a474f44d93
name: GALNT11
boundary condition: true
is encoded by: hsa:63917
is: B3KWF4
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_105bfcac_020c_4179_88c3_3cbc3ba922ed
boundary condition: true
is encoded by: hsa:1738
name: DLD
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: P09622

metaR r0494
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
reversible: true

metaR MAL Ltx
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
product: MODEL1310110018#
reactant: MODEL1310110018#
name: Transport reaction for malate
fast: false
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_6f343e2a_b955_4b69_a74c_38e5bee0c9f9
is: P14410
type: Species
is: SBO:0000252
name: SI
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6476

http://identifiers.org/biomodels.db/MODEL1310110018#_8873659e_b795_4d21_8cee_b316a3d45eae
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297
name: VNN3:VNN2:VNN1
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_b5bf8fa7_c420_422f_9106_5408d28c614d
type: Species
initial concentration: NaN
name: SGPP1
initial amount: NaN
is: Q9BX95
has only substance units: false
is: SBO:0000252
is encoded by: hsa:81537
boundary condition: true
constant: false

metaR GALASE12ly
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR ABTArm
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
is described by: ECO:0000269
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
type: Reaction

metaR BTNPLm
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
kinetic law: MODEL1310110018#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110018#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_7e72b7a1_4622_46e5_be1b_6232d495bfde
name: B3GNT7
is encoded by: hsa:93010
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q8NFL0
constant: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_e523f2cd_81c2_4a8e_941a_69e7e168664d
boundary condition: true
name: HAS1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:3036
initial concentration: NaN
has only substance units: false
is: Q8IYH3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_3abcc798_ef5d_41fb_9061_5d48d112b50f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2629
initial amount: NaN
name: GBA
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaR ADCim
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reversible: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD

metaR FUM
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
name: fumarase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110018#
is described by: ECO:0000000

metaM cs a deg1 l
boundary condition: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16953
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
is: HMDB00812
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_de652e8f_2c04_4f40_a053_cfd3173c000c
initial concentration: NaN
has only substance units: false
name: UGDH
constant: false
is: O60701
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:7358
initial amount: NaN

metaM ins e
boundary condition: false
name: Inosine
type: Species
constant: false
initial amount: NaN
is: HMDB00195
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
initial concentration: 1.0
is: CHEBI:17596
is: SBO:0000247

metaR r0788
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true

metaM uacgam c
initial concentration: 1.0
is: CHEBI:57705
type: Species
is: HMDB00290
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110018#_9804dda0_b242_43a1_9da7_3cd6492d901b
is: SBO:0000252
is encoded by: hsa:51166
initial amount: NaN
initial concentration: NaN
name: AADAT
boundary condition: true
constant: false
is: Q8N5Z0
type: Species
has only substance units: false

metaR PNP
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
name: purine-nucleoside phosphorylase
reversible: true

metaM 3dhguln c
initial amount: NaN
is: HMDB06334
initial concentration: 1.0
boundary condition: false
is: CHEBI:57655
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
type: Species
has only substance units: false
name: 3-dehydro-L-gulonate
constant: false

metaR NCAMUP
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Nicotinamide acid uptake
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
type: Reaction

metaM xol7ah2 m
is: HMDB06893
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
is: CHEBI:28047
constant: false
type: Species
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_b5dbda63_dfbe_4f05_8a14_fd9396ff2123
is: P11926
initial concentration: NaN
is encoded by: hsa:4953
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ODC1

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r0354
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110018#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_306d6523_c266_4672_8c67_5d45b17d836d
is: SBO:0000252
type: Species
is: P04745
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:277
name: AMY1B

metaM q10h2 e
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
is: HMDB13111
boundary condition: false
name: Ubiquinol-10
initial amount: NaN

metaR CHOLtn
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000000
name: Choline transport, nuclear through pores
type: Reaction
is: SBO:0000185

metaR r1051
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR r1567
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false

metaR r1454
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR HACD9m
modifier: MODEL1310110018#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110018#
is described by: ECO:0000134

metaM prostgh2 e
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
is: SBO:0000247
is: HMDB01381
constant: false
initial amount: NaN
is: CHEBI:57405
boundary condition: false
name: prostaglandin H2(1-)

metaM b2coa m
has only substance units: false
initial concentration: 1.0
name: crotonoyl-CoA(4-)
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
constant: false
is: CHEBI:57332
initial amount: NaN
is: HMDB02009
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ab680f43_e882_40be_81f5_8bd89c3e443b
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:374907
constant: false
initial concentration: NaN
type: Species
name: B3GNT8
is: Q7Z7M8
boundary condition: true

metaM sphgn c
initial amount: NaN
type: Species
name: sphinganine(1+)
is: HMDB00269
constant: false
is: CHEBI:57817
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_203738f4_d725_4fbd_a979_e8724d1d9bc4
is encoded by: hsa:65985
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q86V21
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: AACS

metaR r1050
fast: false
name: Vesicular transport
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaM pchol hs r
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16110
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_b80d4d04_07c4_4a67_8796_a7df387396b0
initial concentration: NaN
is encoded by: hsa:275
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P48728
constant: false
name: AMT
initial amount: NaN
type: Species

metaR r2001
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1568
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0797
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
name: glycine N-choloyltransferase EC:2.3.1.65
fast: false
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaM pyr m
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
constant: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
has only substance units: false
name: pyruvate
is: CHEBI:15361
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00022

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:32372
boundary condition: false
type: Species
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)
is: HMDB03229
initial amount: NaN

metaM xol7ah2al c
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
type: Species
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:27428

metaR r2420
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000

metaM ksii core4 pre6 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: CHEBI:28067

metaM q10h2 c
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
constant: false
is: SBO:0000247
name: Ubiquinol-10
boundary condition: false
is: HMDB13111
has only substance units: false

metaR THYOXt
name: T4 transport via bicarbonate countertransport
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000269
type: Reaction

metaR UMPKm
name: UMP kinase (mitochondrial, ATP)
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000134

metaR r1565
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
fast: false

metaR r0796
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
modifier: MODEL1310110018#
type: Reaction

metaR MERCPLACCYSt
type: Reaction
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_af7b86d8_02a3_46b1_aab1_8c2ff09198c6
type: Species
initial concentration: NaN
is encoded by: hsa:8836
has only substance units: false
is: SBO:0000252
is: Q92820
initial amount: NaN
boundary condition: true
constant: false
name: GGH

http://identifiers.org/biomodels.db/MODEL1310110018#_94c95ba1_b470_4c20_a4dd_b747c9fad39f
has part: Q96I99
name: SUCLG2:SUCLG1
constant: false
initial amount: NaN
is: SBO:0000297
type: Species
has part: P53597
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8802
has only substance units: false
is encoded by: hsa:8801

metaM uacgam g
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00290
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaM CE4792 m
is: CHEBI:57923
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
constant: false
boundary condition: false
name: 3-oxo-cis-8-tetradecenoyl-CoA

metaM betald c
has only substance units: false
is: CHEBI:15710
is: HMDB01252
constant: false
type: Species
is: SBO:0000247
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM 3m4hpga m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7909
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
constant: false
has only substance units: false
is: HMDB04061
is: C05583
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a9f11eb5_9f74_4466_8354_df4633491ae0
name: PEMT
is encoded by: hsa:10400
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9UBM1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaM dd2coa x
is: CHEBI:57330
type: Species
is: HMDB03712
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-Dodec-2-enoyl-CoA

metaR THYMt
is: SBO:0000185
name: thymine reversible transport via facilated diffusion
fast: false
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_f3b40351_02ed_462b_b2e3_92821a15c58a
name: SLC12A4
type: Species
initial concentration: NaN
is encoded by: hsa:6560
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: F5H066
has only substance units: false

metaR AMETtd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110018#
is described by: ECO:0000134
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#

metaR r1453
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_3b461696_a64f_4361_9d7c_54bfab18c7cb
initial amount: NaN
name: MCCC2
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: Q9HCC0
is encoded by: hsa:64087
boundary condition: true
has only substance units: false

metaR UMPKn
reversible: true
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
name: UMP kinase, nuclear

metaR r1566
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110018#
type: Reaction

metaR S6TASE21ly
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is: SBO:0000176
reactant: MODEL1310110018#
reversible: true

metaM gua e
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: guanine
is: CHEBI:16235
is: HMDB00132
initial concentration: 1.0
initial amount: NaN
constant: false

metaM akg e
initial amount: NaN
type: Species
name: 2-oxoglutarate(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00208

metaM nadp e
type: Species
is: CHEBI:58349
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: NADP+(3-)
is: SBO:0000247
is: HMDB00217
has only substance units: false
constant: false

metaR BTNPL
is described by: ECO:0000000
is: SBO:0000176
name: holocarboxylase synthestase (biotin protein ligase)
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
kinetic law: MODEL1310110018#

metaM cs b l
constant: false
has only substance units: false
is: HMDB02183
is: CHEBI:36005
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
initial concentration: 1.0
notes: FORMULA: C45H66N2O49S4 CHARGE: -6

metaR CSBPASEly
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110018#
fast: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
type: Reaction

metaM acgal l
initial concentration: 1.0
initial amount: NaN
is: HMDB00212
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
is: SBO:0000247
type: Species
is: CHEBI:28037

http://identifiers.org/biomodels.db/MODEL1310110018#_08cd05af_5fc7_4a4b_a10f_36504ccfc762
type: Species
has only substance units: false
name: CDO1
is: Q16878
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1036
initial concentration: NaN

metaM c226coa c
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
constant: false
is: SBO:0000247
is: C16169
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110018#_59e289d3_2d74_4a63_93cd_7b3a2a77677e
initial amount: NaN
name: _AI435857_1_x
is encoded by: hsa:AI435857
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ksi deg11 l
is: CHEBI:12936
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
constant: false
name: keratan sulfate I, degradation product 11
type: Species
is: HMDB00143
is: SBO:0000247

metaR C3STKR2r
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
kinetic law: MODEL1310110018#
name: C-3 sterol keto reductase (zymosterol)
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM ksi pre12 g
initial concentration: 1.0
is: CHEBI:2504
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
type: Species
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 12
is: HMDB06552

http://identifiers.org/biomodels.db/MODEL1310110018#_9c69dc38_cd21_4b75_a369_946925f1485c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AL048840
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: _AL048840_1_c

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR ARSA
modifier: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
name: Arylsulfatase A
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.8

http://identifiers.org/biomodels.db/MODEL1310110018#_46db8564_278e_4dab_af2b_cba4da67375e
has only substance units: false
is: P11310
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:34
boundary condition: true
name: ACADM
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_587708e2_db15_4be0_bc5a_da7d064dac1d
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5244
name: ABCB4
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaM nadp c
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
is: CHEBI:58349
initial concentration: 1.0

metaM itacon m
name: itaconate(2-)
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
type: Species
is: HMDB02092
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17240

http://identifiers.org/biomodels.db/MODEL1310110018#_dcd771a9_1b46_47fd_ac9e_fdcfa29b72cb
name: UAP1L1
boundary condition: true
initial amount: NaN
is: Q3KQV9
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:91373
initial concentration: NaN
constant: false

metaR P45011A1m
reversible: false
modifier: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
is version of: http://identifiers.org/ec-code/1.14.15.6
is: SBO:0000176
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaM n2m2masn g
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
constant: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C11530
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM akg c
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
has only substance units: false
name: 2-Oxoglutarate
initial amount: NaN
is: C00026
is: CHEBI:16810
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00208

http://identifiers.org/biomodels.db/MODEL1310110018#_28dce0f9_d6e5_4c15_8844_b18f5f190414
is: SBO:0000252
constant: false
name: SLCO1B1
initial amount: NaN
is: Q9Y6L6
is encoded by: hsa:10599
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM idour e
constant: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
has only substance units: false
name: L-iduronate
is: HMDB02704
type: Species
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN

metaR CYSASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#
type: Reaction
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110018#

metaR r1569
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_8f9f8c0b_eb6d_49b3_a717_51fdcb584acc
is: SBO:0000252
has only substance units: false
is: Q4F7X0
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:114
boundary condition: true
constant: false
name: ADCY8

metaR r0792
kinetic law: MODEL1310110018#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
modifier: MODEL1310110018#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction

metaR BAAT3x
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000304
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a929554d_851c_4bcb_971b_8fed7ab88b7b
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: PRODH
is: O43272
has only substance units: false
is encoded by: hsa:5625

metaM prostgh2 c
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
initial concentration: 1.0
name: prostaglandin H2(1-)
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_6748419b_cd2d_40aa_8b02_da1c0c24bae7
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AL038231
constant: false
is: SBO:0000252
name: _AL038231_1_c
initial concentration: NaN
type: Species

metaM hdca r
name: Hexadecanoate (n-C16:0)
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
is: C00249
initial concentration: 1.0
is: HMDB00220
is: CHEBI:7896
type: Species
boundary condition: false
constant: false
has only substance units: false

metaR MMEm
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.1.99.1
reversible: true
name: methylmalonyl-CoA epimerase/racemase
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

metaR CHOLtu
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
reversible: true
name: Choline uniport

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_53cf0442_d3bd_4a7e_a78a_7e379d1a00eb
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2954
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: A6NED0
name: GSTZ1
type: Species

metaR r0791
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is: SBO:0000176

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05875
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaM dec24dicoa m
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: 2,4-decadienoylcoa
has only substance units: false
initial concentration: 1.0
is: HMDB01168
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_63246957_4716_4963_8340_f70879f5d74a
is encoded by: hsa:7357
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: UGCG
constant: false
type: Species
is: Q16739
has only substance units: false

metaR ACNAMlt
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
fast: false
product: MODEL1310110018#
reversible: true
name: N-acetylneuraminate transport into lysososme

metaM idour c
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
boundary condition: false
constant: false
name: L-iduronate
is: SBO:0000247
is: HMDB02704
type: Species
is: CHEBI:21338
initial concentration: 1.0

metaM hdcea e
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
is: HMDB03229
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:32372
is: SBO:0000247
type: Species

metaM ala L m
is: HMDB00161
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16977
initial amount: NaN
name: L-alanine
initial concentration: 1.0
constant: false

metaR PPDOx
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
reactant: MODEL1310110018#
product: MODEL1310110018#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reversible: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110018#

metaM q10h2 m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
is: HMDB13111
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
name: Ubiquinol-10

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
name: prostaglandin-c2
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:27555
is: SBO:0000247
initial amount: NaN

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM c12dc x
name: dodecanedioyl carnitine
notes: FORMULA: C19H34NO6 CHARGE: -1
boundary condition: false
is: HMDB03952
is: SBO:0000247
initial amount: NaN
is: C05280
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaM s2l2n2m2m l
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00573
name: de-Fuc form of PA6 (w/o peptide linkage)
initial amount: NaN
is: CHEBI:30825
notes: FORMULA: C84H136N6O62 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110018#_8a348c4b_4445_4d93_89eb_c685e7948984
initial concentration: NaN
is: SBO:0000297
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:7991
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
constant: false

metaM pyr e
name: pyruvate
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
initial amount: NaN
is: CHEBI:15361

http://identifiers.org/biomodels.db/MODEL1310110018#_918e9c7b_4d2a_49ff_8d15_965a3780be9d
is: SBO:0000252
is: Q16836
type: Species
name: HADH
has only substance units: false
boundary condition: true
is encoded by: hsa:3033
initial amount: NaN
initial concentration: NaN
constant: false

metaM HC00460 c
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58044
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
type: Species
constant: false
boundary condition: false

metaR PPDOy
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction

metaR TXASr
is described by: ECO:0000134
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: Thromboxane-A synthase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.5
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#

metaR r1560
type: Reaction
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_8bdf8240_1903_40aa_a7ca_3ae84cd96013
initial amount: NaN
is: SBO:0000252
type: Species
name: ENTPD5
has only substance units: false
is: O75356
is encoded by: hsa:957
constant: false
boundary condition: true
initial concentration: NaN

metaM gdpddman c
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
boundary condition: false
is: CHEBI:57964
initial amount: NaN
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01346
has only substance units: false
type: Species

metaM acgal c
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00212
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
type: Species
name: N-acetyl-D-galactosamine
has only substance units: false
is: CHEBI:28037

metaM hyptaur c
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16668
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
boundary condition: false
is: HMDB00965
initial concentration: 1.0
name: Hypotaurine

metaM pail345p hs c
is: SBO:0000247
has only substance units: false
is: CHEBI:57836
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM HC02207 c
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
has only substance units: false
is: CHEBI:27555
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_15347e25_0557_451f_bd45_1cb7d6dcb239
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AV727634
type: Species
name: _AV727634_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d532b671_d929_48ef_9b32_47e7a751e114
name: NDUFA1
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6IBB5
is encoded by: hsa:4694
constant: false
type: Species

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Phosphatidylcholine
is: CHEBI:16110
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaR FAOXTC142TC122m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_0362c561_5195_49b3_895c_a834dca4c5e1
is encoded by: hsa:134526
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q5FWE9
initial amount: NaN
name: ACOT12
constant: false
initial concentration: NaN
type: Species

metaR PMEVKc
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
modifier: MODEL1310110018#
name: phosphomevalonate kinase, cytosol
is described by: ECO:0000134
kinetic law: MODEL1310110018#

metaM 3octdectecoa m
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR ORNt4m
fast: false
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b85c17d7_a650_4c91_bb09_c456ff34311d
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM betald m
is: CHEBI:15710
is: HMDB01252
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: betaine aldehyde
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576

http://identifiers.org/biomodels.db/MODEL1310110018#_0b2604ca_85c2_40b9_bd13_0c561d5e1611
is: SBO:0000252
type: Species
is: Q16760
boundary condition: true
constant: false
name: DGKD
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8527

http://identifiers.org/biomodels.db/MODEL1310110018#_fb29b985_753b_4a9b_aefe_212e32ece2ff
name: PPCDC
constant: false
boundary condition: true
is: SBO:0000252
is: Q96CD2
is encoded by: hsa:60490
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110018#_decdea3b_e65d_400f_9f6b_0050a7e3684e
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10317
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: B3GALT5

metaM xol7ah2al m
is: CHEBI:27428
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06894
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
constant: false

metaR GLUPROASCT1
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110018#
name: glutamate intake by system ASCT-1 transporter
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reversible: false
type: Reaction

metaR NACHEX15ly
kinetic law: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110018#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110018#

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_eb4f7368_d893_4ffc_9b6a_3a43fcbd53e8
is encoded by: hsa:R39999
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: _R39999_1_c
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_eb9cd50c_c40c_4f2e_8389_2c9950806c4e
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: A0N0X8
type: Species
name: CYP1A1
is encoded by: hsa:1543
boundary condition: true

metaR r1563
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
type: Reaction

metaM elaid e
name: elaidate
initial amount: NaN
is: CHEBI:30825
is: HMDB00573
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR DOPABMO
is version of: http://identifiers.org/ec-code/1.14.17.1
product: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
fast: false
is: SBO:0000176
name: dopamine beta-monooxygenase
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_6ce52220_53fc_46d2_b8f3_81ee4e1235c9
initial amount: NaN
name: NDUFA3
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4696
boundary condition: true
is: O95167
is: SBO:0000252

metaR RE3003M
is described by: ECO:0000000
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
name: RE3003
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110018#
fast: false

metaR FAOXC10C8x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r1459
name: Transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: true
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ddbc1c49_352f_4365_926d_4c345a6094bb
is: SBO:0000252
boundary condition: true
is: Q9BZX2
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7371
name: UCK2
has only substance units: false
type: Species

metaR r1564
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
fast: false
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_99472ebc_234d_452c_a2fa_7260df952563
is: P47712
boundary condition: true
is encoded by: hsa:5321
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: PLA2G4A

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR NDPK5n
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false

metaM m2mpdol U c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28049

metaM idour l
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
initial amount: NaN
is: HMDB02704
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: L-iduronate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_39f11677_b67a_4fd7_9189_723ed851dd78
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O43306
name: ADCY6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:112
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_2d2d1a31_f4ad_4e06_aa3f_d232c0f22491
boundary condition: true
name: RPL36A
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P83881
type: Species
is: SBO:0000252
is encoded by: hsa:6173

metaR DNDPt23m
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269
name: dTDP transport via dGTP antiport
modifier: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_0c32d5f4_f89f_4a2e_af3a_8fe4ebbeb51f
is: B7Z9T9
initial amount: NaN
initial concentration: NaN
type: Species
name: PDE6B
is: SBO:0000252
is encoded by: hsa:5158
constant: false
boundary condition: true
has only substance units: false

metaR r1561
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
type: Reaction

metaM ditp n
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:61382
boundary condition: false
is: HMDB03537

metaM elaid c
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: CHEBI:30825
is: HMDB00573
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: elaidate

http://identifiers.org/biomodels.db/MODEL1310110018#_5800970c_05d8_40a3_b4bc_e5334ab976ab
is encoded by: hsa:54344
has part: O94777
initial amount: NaN
has only substance units: false
has part: Q86TM7
constant: false
is encoded by: hsa:8818
has part: O60762
name: DPM3:DPM1:DPM2
boundary condition: true
is encoded by: hsa:8813
is: SBO:0000297
type: Species
initial concentration: NaN

metaM tettet6coa c
initial concentration: 1.0
constant: false
is: HMDB06516
type: Species
name: tetracosatetraenoyl coenzyme A
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205481
is: C16171
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247

metaR r1562
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c763749b_fdc3_45bd_949b_130de919eae5
constant: false
is encoded by: hsa:1809
name: DPYSL3
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q8IXW6
boundary condition: true
is: SBO:0000252

metaR ACALDt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110018#
name: acetaldehyde reversible transport
reactant: MODEL1310110018#
type: Reaction
reversible: true

metaR DEBRISOQUINEt
reactant: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
name: debrisoquine uniport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false

metaM ksi l
boundary condition: false
is: CHEBI:57455
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
is: C00445
is: HMDB01354

metaM hdcea r
name: palmitoleate
is: CHEBI:32372
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: HMDB03229
has only substance units: false

metaR DM atp c
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
reversible: false
reactant: MODEL1310110018#
name: DM_atp(c)

metaM hdca e
initial concentration: 1.0
type: Species
is: CHEBI:0
notes: FORMULA: C16H31O2 CHARGE: -1
has only substance units: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
boundary condition: false
is: HMDB00220
is: C00249
initial amount: NaN
constant: false

metaM dttp c
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
initial amount: NaN
is: HMDB01342
boundary condition: false
name: dTTP
has only substance units: false
initial concentration: 1.0
is: C00459
is: CHEBI:37568
is: SBO:0000247

metaR NDPK6n
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000304
is: SBO:0000176
reversible: true
type: Reaction

metaR r0345
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110018#_4107b6b6_8b4f_458a_872d_4e382cfe8185
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: P11509
is encoded by: hsa:1548
initial concentration: NaN
name: CYP2A6
is: SBO:0000252

metaR G14T14g
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110018#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR DESAT20 2
fast: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
type: Reaction
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
reversible: false
reactant: MODEL1310110018#

metaR HISyLATthc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_570e6797_68bd_496d_a7a8_18fae3c42a23
is encoded by: hsa:3284
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: HSD3B2
is: SBO:0000252
type: Species
is: P26439

metaM gluside hs l
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:18368
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
has only substance units: false

metaM gmp c
is: SBO:0000247
initial concentration: 1.0
type: Species
name: GMP
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: C00144
boundary condition: false
is: HMDB01397
is: CHEBI:58115
has only substance units: false
constant: false

metaR ADAe
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
name: Adenosine deaminase, extracellular
is: SBO:0000176
reversible: false

metaM c226coa m
is: SBO:0000247
is: C16169
boundary condition: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479

metaR ABUTt2r
kinetic law: MODEL1310110018#
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f5423ed1_dfd9_4b05_8ae1_9c0aafba3339
is: P30566
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ADSL
is encoded by: hsa:158
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_e5b73ce1_5c33_437c_8277_29f074e5442e
is: SBO:0000252
name: DECR1
type: Species
initial amount: NaN
is encoded by: hsa:1666
constant: false
boundary condition: true
initial concentration: NaN
is: Q16698
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ff9f6743_778a_4fe2_b2ea_aaa88a9b204b
name: OXSM
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:54995
is: Q9NWU1

metaM ala B e
has only substance units: false
is: HMDB00056
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: CHEBI:16958
boundary condition: false
name: beta-alanine
type: Species
constant: false

metaR DESAT20 1
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ba35e0f4_e237_4b02_9793_afbf36abe05d
is: SBO:0000252
is: Q13232
boundary condition: true
constant: false
initial amount: NaN
name: NME3
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4832

http://identifiers.org/biomodels.db/MODEL1310110018#_5d26c831_10b2_4920_b8cc_9b6a4d886997
initial amount: NaN
is: P29803
type: Species
initial concentration: NaN
name: PDHA2
boundary condition: true
is encoded by: hsa:5161
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d8741c46_b445_425d_b763_04a497d5190a
initial concentration: NaN
boundary condition: true
is: Q53Y83
is encoded by: hsa:2717
is: SBO:0000252
name: GLA
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM hdca c
is: HMDB00220
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
boundary condition: false
is: CHEBI:7896
initial concentration: 1.0

metaR 4MPTNLte
name: 4-methylpentanal transport
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
type: Reaction
is described by: ECO:0000000

metaR S6TASE16ly
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8d9b03f3_0120_4e08_a343_6e92439339f7
is: SBO:0000252
name: CPOX
is: P36551
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1371
boundary condition: true
initial amount: NaN
constant: false

metaM sphings c
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: CHEBI:57756
constant: false
name: sphingosine(1+)
is: HMDB00252
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r0081
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:

metaM ps hs m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
has only substance units: false
constant: false
name: ps_hs[m]
type: Species
is: SBO:0000247

metaR SERPT
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.50
fast: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
name: serine C-palmitoyltransferase
product: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110018#

metaM gmp g
has only substance units: false
name: GMP(3-)
initial amount: NaN
boundary condition: false
is: CHEBI:58115
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
type: Species
initial concentration: 1.0

metaR CSEPASEly
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_5063e491_570c_43cc_9dd4_0f1e57d3a63b
has only substance units: false
type: Species
is: SBO:0000252
name: CHAT
is: D3DX95
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1103

metaM gmp e
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01397
name: GMP(3-)
boundary condition: false
is: CHEBI:58115
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
has only substance units: false

metaR r0083
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
type: Reaction
is: SBO:0000176
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110018#

metaR NDPK6m
reversible: true
fast: false
is described by: ECO:0000254
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaR Uritm
is described by: ECO:0000269
reactant: MODEL1310110018#
fast: false
type: Reaction
name: uridine facilated transport in mitochondria
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110018#

metaM dttp e
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
is: CHEBI:37568
initial concentration: 1.0
is: HMDB01342
has only substance units: false
boundary condition: false
is: SBO:0000247
name: dTTP(4-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_6b6470c1_db80_4122_86a5_f19a06d2db6d
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: _AI285872_1_c
is encoded by: hsa:AI285872
is: SBO:0000252

metaM ala B c
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: HMDB00056
initial amount: NaN
boundary condition: false
is: CHEBI:16958
is: SBO:0000247
type: Species
has only substance units: false

metaM HC00900 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
name: Methylmalonate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM lanost r
is: SBO:0000247
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
has only substance units: false
type: Species
initial amount: NaN
name: lanosterol
initial concentration: 1.0
boundary condition: false
is: CHEBI:16521
is: HMDB01251

http://identifiers.org/biomodels.db/MODEL1310110018#_8ab9a0eb_85a4_46fe_9c10_999995c3fea8
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: O75489
has only substance units: false
type: Species
initial amount: NaN
name: NDUFS3
is encoded by: hsa:4722

http://identifiers.org/biomodels.db/MODEL1310110018#_8bb66706_5d3d_429f_a533_441a68bcc346
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5287
name: PIK3C2B
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: O00750

http://identifiers.org/biomodels.db/MODEL1310110018#_6d9a991e_3948_4b6d_a157_ecbc9a48b80b
boundary condition: true
is: Q9NWU1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54995
name: OXSM
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_02e9a21c_3195_4d3b_aa2a_907e4ac85480
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4701
name: NDUFA7
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q6FG42
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_0c484ef5_673f_4aa2_81f3_338b2b4ae644
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: SGPL1
initial concentration: NaN
is: O95470
is encoded by: hsa:8879
constant: false

metaM 3mlda e
constant: false
is: http://identifiers.org/pubchem.compound/8122
has only substance units: false
is: HMDB02820
type: Species
boundary condition: false
is: SBO:0000247
is: C05828
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial amount: NaN
initial concentration: 1.0
name: 3-Methylimidazoleacetic acid

http://identifiers.org/biomodels.db/MODEL1310110018#_7a4ad38d_ab98_407d_a1a2_c8efdf8ed750
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:8608
initial concentration: NaN
name: RDH16
is: O75452
type: Species
initial amount: NaN

metaM 4abut c
has only substance units: false
is: CHEBI:3628
initial concentration: 1.0
boundary condition: false
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false
is: C00334
initial amount: NaN
is: HMDB00112
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_05c08e3c_3759_4ebb_a0ac_1a1d46208c4e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: P23219
has only substance units: false
name: PTGS1
is encoded by: hsa:5742
boundary condition: true

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_4144ecdf_e1f2_4bf2_a400_ddb63eb43252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:R06874
initial concentration: NaN
is: SBO:0000252
name: _R06874_1_r
constant: false
boundary condition: true

metaR ASNALANaEx
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: false
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_1de247d9_bb29_4b28_ac6d_8eda4acd9005
is: Q02218
type: Species
initial amount: NaN
name: OGDH
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4967
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_7202a45a_2e11_4636_b886_88c9203fedb5
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1103
initial amount: NaN
constant: false
name: CHAT
has only substance units: false
is: P28329
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_fed9b035_e935_4c02_845a_16906fb98d10
type: Species
is: Q59E93
name: ANPEP
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:290
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_92f99e71_7928_4968_bf35_f1a30eb47cfa
name: _AA081045_1_m
is encoded by: hsa:AA081045
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_9a997069_7ebe_41d1_a59e_deab26e541c4
is: SBO:0000252
boundary condition: true
is: Q53HM1
constant: false
initial amount: NaN
type: Species
name: UCKL1
has only substance units: false
is encoded by: hsa:54963
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_3be2cba2_c269_41a9_bbc9_926be16ad780
name: HSD11B1
boundary condition: true
is encoded by: hsa:3290
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: P28845

http://identifiers.org/biomodels.db/MODEL1310110018#_7a25b0df_848c_4dfc_9e14_9f90b31a021b
constant: false
is: Q15849
is encoded by: hsa:8170
type: Species
name: SLC14A2
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM apoC Lys btn c
constant: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247

metaR RE0926E
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110018#
name: RE0926
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
modifier: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000

metaM gluside hs g
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
is: CHEBI:18368
constant: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
type: Species

metaR r2408
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
modifier: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false

metaM gln L c
initial amount: NaN
constant: false
is: HMDB00641
type: Species
name: L-glutamine
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR PYAM5POr
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
name: pyridoxamine 5'-phosphate oxidase
is version of: http://identifiers.org/ec-code/1.4.3.5

http://identifiers.org/biomodels.db/MODEL1310110018#_b8529b43_99f1_45ac_8d3d_987bf84e3de3
initial concentration: NaN
type: Species
is: SBO:0000252
is: O15245
boundary condition: true
is encoded by: hsa:6580
constant: false
has only substance units: false
initial amount: NaN
name: SLC22A1

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_9d8b4b83_84fa_4dea_bc67_edc3e26b678b
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:NM 001929
has only substance units: false
boundary condition: true
constant: false
name: _NM_001929_1_c

metaR UMPK7
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110018#
reversible: true
name: UMP kinase (dGTP)
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM 13dpg c
is: SBO:0000247
boundary condition: false
is: C00236
constant: false
is: CHEBI:57604
is: HMDB01270
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaR EX hcoumarin LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxy coumarin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_1a5b9dc4_e5ab_416b_9a44_346a68631917
has only substance units: false
name: _AI653169_1_c
is encoded by: hsa:AI653169
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_65d63364_b24b_4c21_a479_7cd24bc5540c
is encoded by: hsa:57282
name: SLC4A10
initial amount: NaN
initial concentration: NaN
is: B7Z1R0
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_708139f7_179b_4144_81f2_9907f1a8d3e7
type: Species
is: P52790
is: SBO:0000252
is encoded by: hsa:3101
boundary condition: true
initial amount: NaN
name: HK3
has only substance units: false
initial concentration: NaN
constant: false

metaR UMPK6
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
name: UMP kinase (dCTP)

metaM 3mlda c
is: http://identifiers.org/pubchem.compound/8122
is: SBO:0000247
is: C05828
has only substance units: false
is: HMDB02820
initial concentration: 1.0
boundary condition: false
constant: false
name: 3-Methylimidazoleacetic acid
initial amount: NaN
type: Species
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828

metaR NACHEX14ly
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
reversible: false
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal

metaM 35cgmp n
is: HMDB01314
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial amount: NaN
name: 3',5'-cyclic GMP(1-)
has only substance units: false
is: CHEBI:57746
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_8fbc2ef0_847c_4622_8480_ce693c05e1ec
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4731
has only substance units: false
initial concentration: NaN
name: NDUFV3
initial amount: NaN
is: P56181
constant: false

metaR SUCCTD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_6442b427_5721_42aa_ac00_2d48674b19be
name: ALAD
constant: false
type: Species
initial concentration: NaN
is: P13716
is encoded by: hsa:210
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b7622aae_3ba1_44d6_8b7d_3b52b603e0d3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84076
name: TKTL2
constant: false
boundary condition: true
is: Q9H0I9
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_abd4d6f4_7955_4e03_b5fb_45f47924131d
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P42765
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
type: Species

metaR RE1520M
name: RE1520
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
product: MODEL1310110018#

metaM HC01444 e
constant: false
name: Galactosylglycerol
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
type: Species
initial amount: NaN

metaM hs deg23 l
constant: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB02704
is: CHEBI:21338
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_b74f8254_e195_47f4_8ae9_c7382a067af1
is encoded by: hsa:5281
type: Species
has part: Q8TEQ8
initial amount: NaN
has only substance units: false
is: SBO:0000297
name: PIGF:PIGO
boundary condition: true
has part: Q07326
is encoded by: hsa:84720
initial concentration: NaN
constant: false

metaR DOLPMT1 Uer
reversible: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.258
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110018#
fast: false
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

metaR UMPK5
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110018#
reversible: true
name: UMP kinase (dATP)
reactant: MODEL1310110018#

metaR UDPACGALtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
name: udpacgal intracellular transport
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_6c9d3fc0_a8e9_43a5_94be_6318a0d4e699
boundary condition: true
initial amount: NaN
name: _AI469183_1_x
type: Species
is encoded by: hsa:AI469183
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM gln L e
is: HMDB00641
type: Species
is: CHEBI:18050
boundary condition: false
name: L-glutamine
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_399f3996_2020_431d_850a_8f209167996b
constant: false
is: Q9HAS3
initial amount: NaN
is encoded by: hsa:64078
has only substance units: false
type: Species
name: SLC28A3
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM mal L x
name: (S)-malate(2-)
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110018#_2b82195e_1263_4ecb_a237_eea6af5ab6d2
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:56901
name: NDUFA4L2
is: Q9NRX3
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_dae73f14_519b_4902_9be2_d0e9ce685f1d
is: Q9NPC4
initial concentration: NaN
has only substance units: false
name: A4GALT
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:53947
boundary condition: true

metaM ksii core2 pre7 g
has only substance units: false
is: HMDB06552
is: CHEBI:2504
initial amount: NaN
constant: false
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 7

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_abcb1772_cfcd_4659_b7de_012f4217d91c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30061
is: Q9NP59
name: SLC40A1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c33936b1_13d1_4359_95bc_32f2f8627a6d
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: H7C5B8
initial amount: NaN
is encoded by: hsa:4708
initial concentration: NaN
boundary condition: true
name: NDUFB2

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is: P48065
boundary condition: true
name: SLC6A12
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6539
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0779
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_5bd7397d_bee3_451b_8f48_e917584b239b
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:7991
is: Q13454
name: TUSC3
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

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name: _AA278423_1_m
has only substance units: false
type: Species
is encoded by: hsa:AA278423
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_48026d46_b29d_4352_817e_4485c5c2a07d
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: SARDH
initial concentration: NaN
has only substance units: false
type: Species
is: A8K596
is encoded by: hsa:1757

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initial concentration: NaN
type: Species
is: P82251
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11136
name: SLC7A9

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_8920ead6_5150_49db_937b_7ab36b1a3143
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SMPD3
is encoded by: hsa:55512
boundary condition: true
is: A8K0T6
constant: false
initial concentration: NaN
type: Species

metaM m8masn r
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876

metaR NADPNe
is version of: http://identifiers.org/ec-code/3.2.2.5
is: SBO:0000176
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
kinetic law: MODEL1310110018#
fast: false
name: NADP nucleosidase,extracellular

metaM strch2 e
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0
is: HMDB00122
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:4167
boundary condition: false
initial amount: NaN

metaR r0627
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product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23

metaM HC01842 c
boundary condition: false
has only substance units: false
is: CHEBI:31997
name: Phosphodimethylethanolamine
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110018#_5b685b01_37fa_44bb_97d0_0c72328b9374
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2182
name: ACSL4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O60488

metaR SACCD3m
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is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: false
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.8
type: Reaction
modifier: MODEL1310110018#

metaM pppg9 m
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01097
boundary condition: false
name: Protoporphyrinogen IX
constant: false
is: C01079
is: SBO:0000247
is: CHEBI:57307
initial amount: NaN
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079

metaR FAS140COA
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name: fatty-acyl-CoA synthase (n-C14:0CoA)
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction

metaM m2mn l
has only substance units: false
is: HMDB06537
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false

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type: Species
name: SLC23A1
boundary condition: true
is encoded by: hsa:9963
initial amount: NaN
constant: false
is: Q9UHI7
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM c8dc x
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initial amount: NaN
has only substance units: false
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false

metaM ksi e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I
boundary condition: false
is: HMDB00211
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17268
initial amount: NaN
constant: false

metaM asp L m
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is: SBO:0000247
name: L-aspartate(1-)
boundary condition: false
is: HMDB00191
constant: false
type: Species
has only substance units: false
is: CHEBI:29991
initial amount: NaN
initial concentration: 1.0

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is encoded by: hsa:25841
initial amount: NaN
type: Species
is: E9PRW7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: ABTB2

http://identifiers.org/biomodels.db/MODEL1310110018#_768d3ae8_65a4_4ed0_9a7c_2c2ecc11f670
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2805
is: P17174
initial concentration: NaN
constant: false
name: GOT1
is: SBO:0000252

metaM hexccoa x
type: Species
name: Hexacosanoyl-CoA (n-C26:0CoA)
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: HMDB06459
constant: false

metaM 4abut e
notes: FORMULA: C4H9NO2 CHARGE: 0
constant: false
initial concentration: 1.0
is: C00334
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:3628
is: SBO:0000247
initial amount: NaN
name: 4-Aminobutanoate
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110018#_9e28c1ec_f7f1_421d_a63f_12c8be37bf2e
is: E9PCI1
has only substance units: false
initial amount: NaN
name: ACP2
is encoded by: hsa:53
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM dttp n
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initial amount: NaN
is: HMDB01342
is: SBO:0000247
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
is: CHEBI:37568
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_c804750c_4eec_44b2_aed1_6fd54d2a388d
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P18283
type: Species
name: GPX2
is encoded by: hsa:2877
has only substance units: false
initial concentration: NaN

metaM prgnlone c
type: Species
initial concentration: 1.0
is: CHEBI:16581
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
is: SBO:0000247
name: pregnenolone
is: HMDB00253

http://identifiers.org/biomodels.db/MODEL1310110018#_1346988b_5600_4b8a_9eec_43c935aaf2e6
is encoded by: hsa:10965
is: P49753
name: ACOT2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_4f1779f0_13ee_48ac_98bc_3dcdd291ecf4
initial concentration: NaN
initial amount: NaN
is: A8K460
is encoded by: hsa:8398
name: PLA2G6
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaM man6p c
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB01078
boundary condition: false
name: D-Mannose 6-phosphate
is: CHEBI:17369
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

http://identifiers.org/biomodels.db/MODEL1310110018#_042418ff_c120_4035_8d6b_6efa9639f2f1
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:204
name: AK2

metaM hdca l
is: SBO:0000247
name: palmitate
initial amount: NaN
is: CHEBI:7896
has only substance units: false
is: HMDB00220
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

http://identifiers.org/biomodels.db/MODEL1310110018#_eb5448c7_1f8b_4df8_a8a0_a76e43744d21
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c

metaR NDP8ex
fast: false
name: nucleoside-diphosphatase (UTP), extracellular
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110018#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM c226coa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
type: Species
initial amount: NaN
is: C16169
has only substance units: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false

metaM dttp m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: dTTP
has only substance units: false
is: HMDB01342
type: Species
is: C00459
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
is: CHEBI:37568

metaR G12MT1 U
fast: false
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110018#
reversible: false

metaR r0629
product: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.22
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110018#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65

metaM gumtchol e
type: Species
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: guar gum-taurocholic acid complex
constant: false
is: http://identifiers.org/pubchem.compound/93131
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM ps hs e
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: phosphatidylserine
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

http://identifiers.org/biomodels.db/MODEL1310110018#_2d795382_fcc3_46c5_a798_13f9f533e3cb
is: Q96RV2
boundary condition: true
is: SBO:0000252
has only substance units: false
name: HAS3
type: Species
initial concentration: NaN
is encoded by: hsa:3038
initial amount: NaN
constant: false

metaM ksi g
is: CHEBI:57255
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
initial amount: NaN
is: HMDB01014
has only substance units: false

metaR NACHEX17ly
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_d8fcc536_7bf7_467f_b3f3_1a1588c07cfb
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P33402
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2977
name: GUCY1A2
initial concentration: NaN

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR AG13T11g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false

metaM ppi c
is: CHEBI:0
is: C00013
boundary condition: false
name: Diphosphate
type: Species
is: HMDB00250
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: HO7P2 CHARGE: -3
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3789c5c0_e9d6_4eab_bddd_0134d02bfca0
is: Q00796
is: SBO:0000252
has only substance units: false
name: SORD
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6652
initial concentration: NaN
initial amount: NaN

metaR PROSTGD2t
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
reversible: true
modifier: MODEL1310110018#

metaR FAOXC12DCTc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaM 35cgmp c
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01314
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57746
name: 3',5'-cyclic GMP(1-)
has only substance units: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942

metaR GALASE15ly
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110018#
name: beta-galactosidase, lysosomal
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176

metaR r0084
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_97647227_0a12_4a6e_80b8_26d0f5f4915a
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q8N0W3
initial concentration: NaN
type: Species
name: FUK
is encoded by: hsa:197258
boundary condition: true

metaR ACITL
name: ATP-Citrate lyase
kinetic law: MODEL1310110018#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8
reactant: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: false

metaM HC01415 m
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:27537
name: (2E)-Octenoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_cbff4820_5b2a_4f52_9a43_58a3310e43f8
initial amount: NaN
has only substance units: false
is: Q04760
is: SBO:0000252
type: Species
name: GLO1
is encoded by: hsa:2739
constant: false
initial concentration: NaN
boundary condition: true

metaM dump c
initial amount: NaN
boundary condition: false
is: C00365
has only substance units: false
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
initial concentration: 1.0
constant: false
type: Species
name: dUMP
is: SBO:0000247

metaR KSII CORE2tly
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r0085
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110018#_d76d6154_9885_43d3_ae27_1b5ba21f3d02
is: SBO:0000252
is encoded by: hsa:65010
name: SLC26A6
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q9Y3Y1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_3825b0d1_95bb_4e07_b06e_0049ddcd6d8d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9791
has only substance units: false
type: Species
is: P48651
constant: false
boundary condition: true
name: PTDSS1

metaM ppi e
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00250
boundary condition: false
is: SBO:0000247
is: CHEBI:33019
name: Diphosphate
constant: false
initial concentration: 1.0

metaR FAOXC164C143m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM xol27oh r
initial amount: NaN
is: SBO:0000247
name: 26-hydroxycholesterol
has only substance units: false
is: CHEBI:17703
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
is: HMDB02103
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_46246408_e046_43d3_b965_1487860dff8e
boundary condition: true
is: SBO:0000252
name: GALNT4
has only substance units: false
initial amount: NaN
is: Q8N4A0
is encoded by: hsa:8693
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ee590a52_728d_4b1d_bd30_59ed48dc2812
initial concentration: NaN
name: ETFB
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P38117
is: SBO:0000252
type: Species
is encoded by: hsa:2109

metaR DCTPtn
type: Reaction
name: dCTP diffusion in nucleus
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110018#
is: SBO:0000185
fast: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR CYSALANaEx
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaR r0086
product: MODEL1310110018#
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.3
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:

metaM glysar e
notes: FORMULA: C5H10N2O3 CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Glycylsarcosine
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/93131
initial amount: NaN
constant: false

metaR CO2ter
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110018#

metaM g1m8mpdol U r
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
is: CHEBI:59093
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_e74e0acf_696a_448b_b426_690645e43076
is: SBO:0000252
name: ACOX1
initial amount: NaN
is: B4DK61
boundary condition: true
is encoded by: hsa:51
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_af89e833_236b_41fe_8ead_1beabf07628b
initial concentration: NaN
type: Species
is encoded by: hsa:27010
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: F5GZG6
name: TPK1
is: SBO:0000252

metaM gluside hs r
boundary condition: false
initial amount: NaN
type: Species
name: D-glucosyl-N-acylsphingosine
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR r0340
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3ce0633a_8031_4823_8f39_3682fbfbaec2
is: P19801
type: Species
name: ABP1
initial concentration: NaN
constant: false
is encoded by: hsa:26
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM gln L m
has only substance units: false
boundary condition: false
constant: false
is: HMDB00641
is: CHEBI:18050
is: SBO:0000247
initial concentration: 1.0
type: Species
name: L-glutamine
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM asp L e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29991
constant: false
type: Species
is: HMDB00191
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
initial amount: NaN
boundary condition: false

metaM pap c
name: adenosine 3',5'-bismonophosphate(4-)
initial amount: NaN
is: HMDB00061
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
constant: false
is: CHEBI:58343

http://identifiers.org/biomodels.db/MODEL1310110018#_1894df91_e000_4e8d_a41e_ca9920ec5df5
is encoded by: hsa:1119
initial amount: NaN
is: P35790
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: CHKA

metaR r0784
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_354043a8_9137_43f1_8d22_22aca41133c7
is encoded by: hsa:956
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: O75355
name: ENTPD3
initial amount: NaN

metaR r1464
name: Active transport
fast: false
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#

metaR Ser Thrtg
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: Ser/Thr transport (from golgi to lysosome)
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
product: MODEL1310110018#
is: SBO:0000185

metaR SUBERCROT
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c64c1f22_8a0d_497d_be78_36bb33dfbc70
is encoded by: hsa:5281
has only substance units: false
is encoded by: hsa:84720
initial amount: NaN
has part: Q6IB04
type: Species
name: PIGF:PIGO
is: SBO:0000297
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_d5d97f7f_2163_4648_9d4a_a796f8f4d893
initial concentration: NaN
name: ABCA1
is encoded by: hsa:19
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O95477

metaM glysar c
notes: FORMULA: C5H10N2O3 CHARGE: 0
constant: false
is: SBO:0000247
name: Glycylsarcosine
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/93131
has only substance units: false
boundary condition: false
type: Species

metaR BILIRED
fast: false
name: Nad(p)h biliverdin reductase
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is version of: http://identifiers.org/ec-code/1.3.1.24

metaR r1578
reactant: MODEL1310110018#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#

metaR r0783
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110018#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110018#_58c07025_a75b_4346_b415_c48d1c13bb8d
name: UEVLD
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55293
is: Q8IX04
boundary condition: true
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_c0d0fdd8_581f_4e18_8694_259f39b2323f
constant: false
initial amount: NaN
is encoded by: hsa:7991
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: TUSC3

metaR PALFATPtc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR SPC HSt
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
fast: false
product: MODEL1310110018#
name: sphingosylphosphorylcholine transport (diffusion)
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ecfa284f_ae3a_4b1b_b0bb_9b40bc5e976a
has only substance units: false
name: SLC23A1
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a0ae9281_1dbf_4eae_adf6_5df9d221db66
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51227
is: SBO:0000297
type: Species
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
boundary condition: true

metaR DNDPt24m
reactant: MODEL1310110018#
name: dTDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
kinetic law: MODEL1310110018#
is: SBO:0000185

metaR r1579
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaR r1466
product: MODEL1310110018#
name: EC:2.3.1.86
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_45e946bc_3caf_4047_a793_689804c911a4
is: H7C5B8
initial amount: NaN
is encoded by: hsa:4708
name: NDUFB2
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR BAAT4x
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
reactant: MODEL1310110018#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM pppg9 c
initial amount: NaN
boundary condition: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
has only substance units: false
initial concentration: 1.0
type: Species
name: Protoporphyrinogen IX
is: SBO:0000247
constant: false
is: C01079
is: HMDB01097
is: CHEBI:57307

metaR Q10H2e
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
name: transport of ubiquinol into lymph
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a03d90b4_b843_41d7_a903_08b053d18b83
type: Species
name: _AA526438_1_m
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA526438

metaR DOLPMT U
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.83
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
reversible: false
modifier: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_fb47310d_0396_41c1_a3ca_1a3b0b9d8466
is: C9JZ62
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:641649
name: TMEM91
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_1a0d7075_8d08_452c_87b8_dbdba8c7e6d1
boundary condition: true
has only substance units: false
name: SLC1A5
initial concentration: NaN
is encoded by: hsa:6510
initial amount: NaN
is: Q15758
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f52a8ef0_1792_4f93_821a_c7a1304a1064
boundary condition: true
initial amount: NaN
is: P48200
constant: false
has only substance units: false
initial concentration: NaN
name: IREB2
is encoded by: hsa:3658
is: SBO:0000252
type: Species

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaM ksi deg39 l
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
boundary condition: false
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 39
type: Species
initial amount: NaN
is: SBO:0000247

metaR CRNtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
product: MODEL1310110018#
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_b155cad2_f5d0_486f_884f_aa10643f24dd
initial amount: NaN
constant: false
is encoded by: hsa:54344
initial concentration: NaN
is: SBO:0000252
is: Q9P2X0
boundary condition: true
type: Species
has only substance units: false
name: DPM3

metaM ppi r
is: SBO:0000247
is: C00013
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:33019
name: Diphosphate
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: HMDB00250

metaR NADPHtxu
reversible: false
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is described by: ECO:0000000
name: NADPH transporter, peroxisome
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM HC02023 r
has only substance units: false
constant: false
name: Cholesterol-ester-ol
type: Species
is: CHEBI:46898
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
initial amount: NaN
boundary condition: false

metaR CH25H
reversible: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.99.38
type: Reaction
name: cholesterol 25-hydroxylase
is: SBO:0000176
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_0c36be07_5ccd_477e_b584_3f309e76ad16
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:763
name: CA5A
constant: false
is: P35218
has only substance units: false
type: Species
initial concentration: NaN

metaM apoC Lys btn m
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
is: C05552
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
initial amount: NaN
constant: false

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is described by: ECO:0000000
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
is: SBO:0000176

metaR r0908
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ad8d9e38_4388_42d0_bfca_a0ea93dbd0bd
has part: Q9HCC0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: MCCC1:MCCC2
is encoded by: hsa:56922
is: SBO:0000297
is encoded by: hsa:64087
has part: Q96RQ3
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_ceb3fa43_ced4_4c1b_a818_1f5a673dd24b
constant: false
is: SBO:0000252
initial concentration: NaN
name: HMGCS2
is: P54868
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:3158
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_1f5b886b_db47_4386_8647_84235f9a933e
name: GGT1
is: SBO:0000252
constant: false
is encoded by: hsa:2678
is: P19440
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_90736826_a564_4af8_9eb8_d04047980b38
constant: false
initial concentration: NaN
is: Q9NY97
has only substance units: false
type: Species
is encoded by: hsa:10678
is: SBO:0000252
boundary condition: true
name: B3GNT2
initial amount: NaN

metaR CYTK9n
fast: false
product: MODEL1310110018#
name: cytidylate kinase (CMP,dCTP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction

metaM ps hs c
type: Species
is: SBO:0000247
name: ps_hs[c]
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaM ppi m
is: HMDB00250
is: SBO:0000247
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
is: CHEBI:33019
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: C00013

metaM pap g
is: CHEBI:58343
boundary condition: false
has only substance units: false
type: Species
is: HMDB00061
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110018#_22d4996e_4515_40ae_b64a_775550c10601
is encoded by: hsa:125965
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q6YFQ2
type: Species
name: COX6B2
has only substance units: false
initial amount: NaN

metaM ksii core4 pre8 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
is: HMDB06552
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:2504
type: Species
notes: FORMULA: C83H134N7O61SX CHARGE: -2
boundary condition: false
has only substance units: false

metaR G5SADrm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
fast: false
product: MODEL1310110018#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_85807807_4c09_41b8_9d59_8fcc3a420d1a
type: Species
is: P19961
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:280
initial amount: NaN
name: AMY2B
has only substance units: false

metaR GLCNACASE1ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110018#
type: Reaction
fast: false
product: MODEL1310110018#
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR CMPACNAtn
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: CMP-Sia nuclear export
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false

metaR GALASE7ly
fast: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_eb0c3fdc_b7b6_4300_929b_3e8e9b4b739c
is: SBO:0000252
is: D3DX95
name: CHAT
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1103
initial concentration: NaN

metaR r0782
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#

metaR LDH D
name: D-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
kinetic law: MODEL1310110018#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_ebc4d768_a8a3_436e_8112_4ece3ffb9128
is: Q9UMR5
constant: false
name: PPT2
is encoded by: hsa:9374
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.21
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_21b23a1b_6821_4209_bd5f_396980f20af7
initial amount: NaN
name: IMPA2
is: SBO:0000252
has only substance units: false
type: Species
is: O14732
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3613

http://identifiers.org/biomodels.db/MODEL1310110018#_3053a2b0_0b73_48a7_b367_c0baf4f707a6
is: Q13510
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ASAH1
is: SBO:0000252
is encoded by: hsa:427
boundary condition: true
has only substance units: false

metaM trdrd c
initial concentration: 1.0
is: CHEBI:15967
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
is: SBO:0000247
name: Reduced thioredoxin
type: Species

metaR r0781
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
fast: false

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000134
reversible: false
fast: false
kinetic law: MODEL1310110018#
name: geranyltranstransferase

metaM ppi n
initial amount: NaN
is: CHEBI:33019
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: diphosphate(3-)
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: HMDB00250

metaR BMTer U
fast: false
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
name: B mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
kinetic law: MODEL1310110018#

metaM asp L c
is: SBO:0000247
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
is: CHEBI:29991
initial concentration: 1.0
is: HMDB00191
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaM tststerone c
is: HMDB00234
name: testosterone
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
is: SBO:0000247
is: CHEBI:17347
initial concentration: 1.0

metaR GLB1
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Beta-galactosidase
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110018#_cad91b8c_463b_45ac_b3a7_d66aa98c77f3
name: ADSS
constant: false
is: P30520
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:159
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR DOLP Uter
name: dolichol phosphate flippase (uterus)
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176

metaM tetpent6coa c
constant: false
is: C16172
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false
initial concentration: 1.0
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false

metaM ksi deg24 l
is: HMDB00143
name: keratan sulfate I, degradation product 24
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
has only substance units: false
is: SBO:0000247

metaM gluside hs c
is: SBO:0000247
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR PCHOLPm hs
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
name: choline phosphatase
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110018#_dc6002a5_9b41_499b_bcbf_e7f5f267d50b
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: Q16706
name: MAN2A1
is encoded by: hsa:4124
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_84a968e9_f051_491d_b93f_d08bcad7e2be
constant: false
initial concentration: NaN
is: Q308M7
is: SBO:0000252
name: ENPP3
has only substance units: false
type: Species
is encoded by: hsa:5169
boundary condition: true
initial amount: NaN

metaR PRO Dtde
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110018#
fast: false
is: SBO:0000185
name: D-proline transport, extracellular
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_55a3bd76_70c3_49e5_9eda_dc0d88b4ea3b
has part: P42336
initial amount: NaN
has only substance units: false
name: PIK3CA:PIK3R2
type: Species
constant: false
is encoded by: hsa:5290
initial concentration: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5296
has part: O00459

metaR ETF
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
reactant: MODEL1310110018#
reversible: false
name: electron transfer flavoprotein
fast: false
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#

metaR OCDCAtr
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false

metaM ala B m
initial concentration: 1.0
name: beta-alanine
initial amount: NaN
is: CHEBI:16958
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00056
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaM so4 e
is: CHEBI:16189
initial amount: NaN
boundary condition: false
is: HMDB01448
type: Species
has only substance units: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR RE2999M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
product: MODEL1310110018#
name: RE2999
reversible: true
type: Reaction

metaM HC02216 e
has only substance units: false
name: prostaglandin-f2beta
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: CHEBI:28922
type: Species
boundary condition: false
initial amount: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM ppi x
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
name: Diphosphate
constant: false
has only substance units: false
is: C00013
is: SBO:0000247
boundary condition: false
is: CHEBI:33019
initial concentration: 1.0
initial amount: NaN

metaM tststerone e
is: HMDB00234
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
has only substance units: false
constant: false
is: CHEBI:17347
boundary condition: false
is: SBO:0000247

metaR RE1804M
type: Reaction
name: RE1804
product: MODEL1310110018#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110018#
is: SBO:0000176

metaM Ser Thr g
initial concentration: 1.0
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00645
is: CHEBI:58336
notes: FORMULA: XH CHARGE: 0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_5a020f90_c66a_44b4_98ac_2dd6c4117b4d
boundary condition: true
constant: false
is: A4D0W4
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AASS
initial concentration: NaN
is encoded by: hsa:10157
type: Species

metaM dump n
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01409
initial concentration: 1.0
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110018#_c6fe1aae_8e5f_4f74_87b9_367c05e5f345
initial concentration: NaN
is encoded by: hsa:6240
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P23921
constant: false
name: RRM1
type: Species

metaM ala D c
type: Species
initial amount: NaN
name: D-alanine
is: CHEBI:15570
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7525c895_3f8e_434a_ac54_0e05ce26920c
type: Species
initial concentration: NaN
has only substance units: false
is: Q14916
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6568
constant: false
name: SLC17A1
initial amount: NaN

metaR FAS160COA
name: fatty-acyl-CoA synthase (n-C16:0CoA)
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: false
reactant: MODEL1310110018#

metaR r1570
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110018#

metaR ALOX52
kinetic law: MODEL1310110018#
name: Arachidonate 5-lipoxygenase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reversible: false
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR r1998
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110018#
modifier: MODEL1310110018#

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB06552
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:2504
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 7
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM thyox L c
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00248
initial concentration: 1.0
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
initial amount: NaN
name: L-thyroxine

metaR SARDHm
name: Sarcosine dehydrogenase (m)
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.99.1
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
fast: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_1128e067_31e2_43b6_a1e9_2d48616dc221
initial concentration: NaN
name: XDH
has only substance units: false
initial amount: NaN
constant: false
is: P47989
type: Species
is encoded by: hsa:7498
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_cf35e568_1d72_4a82_85d6_e3af6b6e61a1
name: GNE
is: SBO:0000252
constant: false
is: B7Z428
boundary condition: true
is encoded by: hsa:10020
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR BUTt2r
name: Butyrate transport via proton symport, reversible
kinetic law: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#

metaR S6TASE18ly
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is described by: ECO:0000000

metaM sphings l
is: CHEBI:57756
type: Species
name: sphingosine(1+)
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR r1571
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3307b26d_0806_410b_a3b3_22e55d326005
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1346
name: COX7A1
is: P24310
constant: false

metaM so4 c
name: sulfate
is: HMDB01448
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
is: SBO:0000247
is: CHEBI:16189
initial concentration: 1.0
has only substance units: false

metaM 3octpencoa m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
constant: false
boundary condition: false
name: 3,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
type: Species

metaM thyox L e
is: HMDB00248
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:18332
initial concentration: 1.0
constant: false
has only substance units: false
name: L-thyroxine

http://identifiers.org/biomodels.db/MODEL1310110018#_5ed553fe_7824_4acf_9fd3_a8676be8c052
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: _U37519_1_m
is: SBO:0000252
type: Species
is encoded by: hsa:U37519

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_63802ddc_3edf_4d20_a6c9_3a90c7dc8e01
has part: B7Z2T0
is encoded by: hsa:478
initial amount: NaN
is encoded by: hsa:481
has only substance units: false
initial concentration: NaN
is: SBO:0000297
boundary condition: true
has part: A3KLL5
type: Species
name: ATP1A3:ATP1B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_4ac51177_b6bd_466c_b24e_9c4954df82a4
is encoded by: hsa:5279
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: PIGC
is: SBO:0000252
constant: false

metaR r2419
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_754f5b2f_6faa_43d6_852d_015026149466
boundary condition: true
type: Species
name: SCD
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6319
initial concentration: NaN
constant: false
is: O00767

metaM pail5p hs c
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR 4MPTNLtm
name: 4-methylpentanal transport (mitochondria)
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
product: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Transport reaction
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#

metaR AHCYStr
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
name: S-Adenosyl-L-homocysteine intracellular diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_e4708498_fe3e_4634_a71c_d3e7cdeb6905
is encoded by: hsa:5283
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: Q14442
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PIGH

metaR r0339
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110018#

metaM Ser Thr l
boundary condition: false
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
is: HMDB00224
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:58190
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0

metaM pyam5p c
constant: false
is: HMDB01555
is: CHEBI:58451
has only substance units: false
is: C00647
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: Pyridoxamine 5'-phosphate

metaM ksii core2 pre2 g
boundary condition: false
is: SBO:0000247
is: HMDB06552
notes: FORMULA: C39H63N3O28X CHARGE: -1
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 2
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:2504

http://identifiers.org/biomodels.db/MODEL1310110018#_6483f4b2_53b6_48a7_a366_ba67632e25aa
initial concentration: NaN
name: LIPA
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3988
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: P38571

metaM ksii core4 deg4 l
is: CHEBI:16953
name: keratan sulfate II (core 4-linked), degradation product 4
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00812
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C66H108N6O48SX CHARGE: -1
type: Species
has only substance units: false

metaR ORNDC
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.1.1.17
product: MODEL1310110018#
is: SBO:0000176
reversible: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
name: Ornithine Decarboxylase
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e572145e_90aa_4e22_bd9b_9bad0cc5c451
name: NDUFS7
initial concentration: NaN
type: Species
is encoded by: hsa:374291
is: O75251
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM HC00900 m
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:30860
has only substance units: false
constant: false
name: Methylmalonate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

http://identifiers.org/biomodels.db/MODEL1310110018#_091491cb_96d6_40f9_aa19_fc86a587232c
has only substance units: false
boundary condition: true
constant: false
is: B3KQH0
is encoded by: hsa:55343
name: SLC35C1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR NADNe
is: SBO:0000176
kinetic law: MODEL1310110018#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.2.2.5
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
name: NAD nucleosidase,extracellular
reversible: false

metaM trdrd m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
name: Reduced thioredoxin
initial amount: NaN
has only substance units: false
type: Species

metaR r1573
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR KYNAKGAT
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
kinetic law: MODEL1310110018#
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_d8af2c02_ec6f_47c2_898b_f5863565719a
is encoded by: hsa:5277
constant: false
is: B3KUV7
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PIGA

metaR r2412
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false

metaR SERtN1
reactant: MODEL1310110018#
name: Serine transport (Na, H coupled)
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true

metaR C8DCe
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of suberyl carnitine into the extra cellular space
type: Reaction

metaR TETPENT6COAtx
fast: false
name: fatty acid intracellular transport
type: Reaction
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_ac442371_0517_41b0_b3f4_bfce8ed3463c
name: IDH2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418
boundary condition: true
is: P48735
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaR H7 TAer
kinetic law: MODEL1310110018#
name: H7' transamidase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110018#
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c87e5f8f_8fc5_4d0d_85f5_22493a5f933a
is: P19801
initial amount: NaN
is encoded by: hsa:26
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: ABP1

metaR MAL Lte
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
fast: false
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000134
type: Reaction

metaR S6TASE22ly
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_be3ab70f_7775_421d_8a0c_f9649be74bb0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: GLRX2
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:51022

metaR LDH L
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110018#
fast: false
name: L-lactate dehydrogenase
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_d49c4086_11c0_4ff7_882b_5494156869ec
is encoded by: hsa:8560
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DEGS1
constant: false
boundary condition: true
is: SBO:0000252

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM HC02216 c
type: Species
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
constant: false
is: CHEBI:28922
has only substance units: false

metaR CMPACNAtg
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is: SBO:0000185
reversible: true
name: CMP-Sia Golgi transport via CMP antiport
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000269
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ea7190e2_486e_4bd7_90be_1ae3fd8da095
name: SLC5A8
initial amount: NaN
type: Species
is encoded by: hsa:160728
is: Q8N695
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1575
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
fast: false
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM Lcyst c
is: HMDB02757
initial concentration: 1.0
name: L-cysteate(1-)
initial amount: NaN
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58090
is: SBO:0000247
constant: false

metaM hexccoa c
is: SBO:0000247
initial concentration: 1.0
is: HMDB06459
initial amount: NaN
has only substance units: false
name: Hexacosanoyl-CoA (n-C26:0CoA)
constant: false
boundary condition: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
type: Species

metaM dhlam m
is: SBO:0000247
is: CHEBI:17694
name: dihydrolipoamide
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00985
has only substance units: false

metaM cs e deg6 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
is: CHEBI:16953
is: HMDB00812
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9e5688f8_d795_4e2d_ae52_25f726bd40f0
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: CAD
boundary condition: true
has only substance units: false
is encoded by: hsa:790
is: P27708

metaR ORNt3m
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is: SBO:0000185
name: ornithine mitochondrial transport via proton antiport
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.49
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaM ala D e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01310
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
constant: false
name: D-alanine
is: CHEBI:15570

http://identifiers.org/biomodels.db/MODEL1310110018#_ad835c39_fb77_4c36_b7a3_3a57514b5868
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is: P30043
name: BLVRB
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:645

metaR r1576
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR C4STMO2Pr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
fast: false
reactant: MODEL1310110018#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110018#
name: C-4 methyl sterol oxidase
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#

metaM estradiol e
is: SBO:0000247
name: estradiol
constant: false
boundary condition: false
is: CHEBI:16469
is: HMDB00151
has only substance units: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
type: Species
initial concentration: 1.0
initial amount: NaN

metaR DM gpi sig er
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_fce0e2b8_0592_4fda_ae3f_f1ce8ba23821
constant: false
is: SBO:0000252
name: GCDH
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: Q92947
has only substance units: false
is encoded by: hsa:2639

metaM gly m
initial concentration: 1.0
name: Glycine
type: Species
is: CHEBI:15428
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
is: HMDB00123
is: C00037

metaM ksi deg31 l
boundary condition: false
type: Species
is: HMDB00812
is: SBO:0000247
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 31
has only substance units: false
is: CHEBI:16953
initial amount: NaN
notes: FORMULA: C90H148N6O72S2 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110018#_0d25682a_391d_43c8_a5cf_1f9a285b76b2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI697028
initial amount: NaN
name: _AI697028_1_e
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_4a73b604_f161_4a1a_b680_264f4c236fb3
has only substance units: false
constant: false
boundary condition: true
is: A8K3L7
initial amount: NaN
is: SBO:0000252
name: CDIPT
is encoded by: hsa:10423
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_e0e2b1a2_06e1_4258_a68f_dffe556c52d4
boundary condition: true
name: GLUL
initial amount: NaN
type: Species
is: P15104
is encoded by: hsa:2752
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_de1d60a3_1d8c_4ae0_bb70_ff2588229f02
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: DLD:DLST:OGDH:PDHX
type: Species
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4967
has part: B4E3E9

metaR RE3565C
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
name: RE3565

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b0e6e19b_a351_4895_9ae4_d3a4cabf59bd
is encoded by: hsa:4712
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4731
type: Species
initial concentration: NaN
has part: Q5VYT2
boundary condition: true

metaR G14T13g
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_0af37adf_5a5c_452c_b644_47a214e87fee
type: Species
initial concentration: NaN
name: PDE7A
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5150
constant: false

metaM sphs1p c
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
initial amount: NaN
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: CHEBI:60119
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00277

metaM HC01401 m
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR METt4
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
name: L-methionine transport in via sodium symport
is described by: ECO:0000269
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_27c9800e_76f1_4381_9fa3_5aaceedeaf94
is encoded by: hsa:23396
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: O60331
name: PIP5K1C

metaR AG13T5g
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
modifier: MODEL1310110018#
is: SBO:0000176

metaR r0097
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#
fast: false
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1

metaM hspg e
initial concentration: 1.0
is: HMDB00719
boundary condition: false
is: CHEBI:15699
type: Species
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
is: SBO:0000247
has only substance units: false
name: heparan sulfate proteoglycan

metaM dmnoncrn x
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
is: SBO:0000247

metaM na1 x
is: SBO:0000247
is: CHEBI:29101
has only substance units: false
boundary condition: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial concentration: 1.0
is: HMDB00588
name: sodium(1+)
type: Species
constant: false
initial amount: NaN

metaR UGLCNACtg
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport

metaR SIAASEly
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176

metaM 2octdectecoa m
name: 2,6,9,12-octadecatetraenoylcoa
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
constant: false

metaR S6TASE15ly
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_3440768e_21b8_482d_a389_7a7a35816d6a
initial concentration: NaN
is: Q96C36
name: PYCR2
is encoded by: hsa:29920
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r2509
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110018#
name: Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_6c333cb0_97e5_49e7_bcfe_b606072e7bb4
type: Species
boundary condition: true
is encoded by: hsa:3098
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A8K7J7
has only substance units: false
name: HK1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b4f4c0cc_fe63_4aa4_b48a_d14a62153304
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5244
type: Species
has only substance units: false
name: ABCB4
boundary condition: true
initial concentration: NaN
is: P21439
constant: false

metaR GULLACter
fast: false
name: gulonolactone endoplasmic reticular transport
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8b3517e6_9f46_4fb1_aea9_1a0661208fe9
name: STS
initial amount: NaN
is encoded by: hsa:412
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: P08842

metaM CE5101 m
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR GCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
reversible: true

metaR URIK1
name: uridine kinase (ATP:Uridine)
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
fast: false
reversible: false
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_19570ff4_d79a_4ddc_b27c_dbabab9b64d3
type: Species
name: ALDH9A1
constant: false
is: P49189
is encoded by: hsa:223
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0618
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_41f4100d_d820_4a60_a699_f6c634fb976d
is encoded by: hsa:4860
initial concentration: NaN
initial amount: NaN
is: P00491
name: PNP
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

metaM amp r
is: HMDB00045
initial amount: NaN
has only substance units: false
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
constant: false
is: CHEBI:456215
type: Species
boundary condition: false
initial concentration: 1.0
is: C00020

metaM na1 r
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:29101
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
initial amount: NaN
is: HMDB00588
name: sodium(1+)
is: SBO:0000247
type: Species

metaR r0722
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.3.12
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_3bbf2cda_680f_45b1_ae4f_eeed4f4e9f0f
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q92185
initial concentration: NaN
is encoded by: hsa:6489
name: ST8SIA1
constant: false
initial amount: NaN

metaM ade c
constant: false
is: SBO:0000247
is: CHEBI:16708
initial concentration: 1.0
is: HMDB00034
type: Species
initial amount: NaN
is: C00147
name: Adenine
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
boundary condition: false

metaR DNDPt42m
is described by: ECO:0000269
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
name: dUTP transport via ADP antiport

metaR r0617
fast: false
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110018#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110018#_2bee9214_b7cf_44ea_8dcf_91df6d0458f1
is: Q02218
boundary condition: true
name: OGDH
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4967

metaR SCP22x
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
fast: false
modifier: MODEL1310110018#
name: Sterol carrier protein 2
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: true

metaR r2507
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000

metaM 6pgl r
is: SBO:0000247
is: HMDB01127
initial amount: NaN
has only substance units: false
is: CHEBI:57955
initial concentration: 1.0
boundary condition: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
type: Species
constant: false

metaR RE2660C
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: RE2660
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#

metaR NODe
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110018#
name: NODe

metaR S6TASE24ly
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR r1292
kinetic law: MODEL1310110018#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8ec2d8fb_47fc_4919_b181_bbd397cd25a1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: ACSS2
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55902
is: Q5QPH3

metaM acac e
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:13705
is: HMDB00060
constant: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate

metaR r0616
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
modifier: MODEL1310110018#

metaR r2508
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110018#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110018#_5746b3c5_dc1b_47a0_b908_4597a3d9902e
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
initial concentration: NaN
name: LDHA:LDHB
initial amount: NaN
type: Species
has part: P00338
has part: P07195
is encoded by: hsa:3945
is encoded by: hsa:3939

metaR r1291
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM xan c
type: Species
has only substance units: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
is: HMDB00292
is: SBO:0000247
constant: false
is: C00385
boundary condition: false
is: CHEBI:17712
initial amount: NaN
name: Xanthine

metaR RE2972M
name: RE2972
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.67
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaR r0720
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_4323f678_bd32_4dee_bd70_a42bd62996f9
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2954
is: O43708
type: Species
name: GSTZ1
has only substance units: false

metaR r0615
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
fast: false
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000

metaR SPRMTDe
name: absorption for spermine across the basolateral side
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
fast: false
product: MODEL1310110018#
is described by: ECO:0000134

metaM ade e
is: HMDB00034
has only substance units: false
is: CHEBI:16708
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
type: Species
name: adenine
constant: false
is: SBO:0000247
boundary condition: false

metaR GALC
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Galactocerebrosidase
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.46
fast: false
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000

metaM gcald c
type: Species
constant: false
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
name: glycolaldehyde
initial amount: NaN
is: SBO:0000247
is: HMDB03344
initial concentration: 1.0
is: CHEBI:17071
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_85c617aa_1852_45bc_87d3_f73b993975c2
has only substance units: false
is encoded by: hsa:51205
is: Q9NPH0
initial concentration: NaN
initial amount: NaN
name: ACP6
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR ILEtec
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: true

metaM ksi deg27 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 27
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
constant: false
type: Species
is: HMDB00143
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_4a1a23c8_e04b_471e_9390_1f731930f8b7
initial concentration: NaN
name: ALG6
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:29929
is: Q9Y672
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_c55c5ec8_42fa_41a5_b141_0bc98775c3ad
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
name: HSD3B1
initial concentration: NaN
boundary condition: true
is: P14060
is encoded by: hsa:3283

metaR ATP2ter
is described by: ECO:0000000
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_69795ce3_1d3e_4300_bef9_0457faf98d5d
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P04183
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:7083
name: TK1

metaR r2506
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
name: Utilized transport
is: SBO:0000185

metaR DCMPDA
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.4.12
reversible: true
fast: false
is described by: ECO:0000254
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase

metaR r0614
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110018#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110018#

metaM sphs1p e
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
is: SBO:0000247
constant: false
initial amount: NaN

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#

metaM thmpp c
is: C00068
has only substance units: false
is: HMDB01372
type: Species
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:45931
boundary condition: false
constant: false
initial amount: NaN
name: Thiamine diphosphate

http://identifiers.org/biomodels.db/MODEL1310110018#_b4b6836b_f372_4d31_ad7c_d772a7d3f640
has only substance units: false
is encoded by: hsa:4725
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: NDUFS5
is: Q6IBA0
initial concentration: NaN

metaR RE3241R
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110018#
name: RE3241
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: false
is described by: ECO:0000000

metaR EX doco13ac
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR TKT1
is: SBO:0000176
reversible: true
name: transketolase
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaM amp e
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: C00020
is: CHEBI:456215
is: HMDB00045
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
boundary condition: false
name: AMP

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:58367
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00286

metaR NADPtru
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#

metaR ACACt2m
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
name: Acetoacetate mitochondrial transport via H+ symport
reversible: true
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_dd676ef4_a45b_4277_aa75_fe8768b43587
initial amount: NaN
is: O43252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: PAPSS1
is encoded by: hsa:9061
boundary condition: true

metaM ksi pre19 g
is: HMDB06552
name: keratan sulfate I biosynthesis, precursor 19
is: CHEBI:2504
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
boundary condition: false
is: SBO:0000247

metaR r0726
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r2133
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM leuktrD4 c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
name: Leukotriene D4
has only substance units: false
is: CHEBI:28666

metaM dolp U c
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
constant: false
is: CHEBI:57683
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaR TKT2
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110018#
is: SBO:0000176
reversible: true
name: transketolase

metaR AG13T16g
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_e6277349_900a_4e6c_a0dc_74046c8dfa91
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152
constant: false
boundary condition: true
initial concentration: NaN

metaM l2fn2m2masn g
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:28067
type: Species
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C68H113N4O49X CHARGE: 0

metaM m6mpdol U r
has only substance units: false
is: SBO:0000247
is: CHEBI:37635
type: Species
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_295be274_e75e_436a_a73b_19c96f1b4025
name: GLA
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: Q53Y83
initial amount: NaN
constant: false
is encoded by: hsa:2717

http://identifiers.org/biomodels.db/MODEL1310110018#_304995de_700a_4383_af3f_28d58053c89e
type: Species
is encoded by: hsa:4719
has only substance units: false
is: P28331
name: NDUFS1
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_8c7f0e5b_55fa_46a3_8f4f_a89e6230fdc4
name: _AD000092_1_c
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AD000092
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_edc0b2e9_aa18_4afc_bb4b_7d83cd06b5be
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AV713053
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: _AV713053_1_m

metaR MI1PS
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.5.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
reactant: MODEL1310110018#
product: MODEL1310110018#
name: myo-Inositol-1-phosphate synthase
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_a8cc8940_f98c_465c_a675_a45cee85179c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6472
initial amount: NaN
is: B4DJQ3
is: SBO:0000252
boundary condition: true
type: Species
name: SHMT2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7078a062_90b7_4836_b040_e746368e7a0f
boundary condition: true
has only substance units: false
type: Species
is: Q86YW0
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:89869
name: PLCZ1

metaM cs e deg1 l
is: HMDB00868
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
boundary condition: false
is: SBO:0000247

metaM etfrd m
initial amount: NaN
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0
is: HMDB00151
name: Electron transfer flavoprotein reduced
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:16469
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_6f5fc326_3993_4e08_9e1c_d488fecc25db
name: NDUFS2
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4720
is: SBO:0000252
type: Species
is: B7Z792

metaR TSTSTERONEtr
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
name: testosterone intracellular transport

metaM arachd r
has only substance units: false
boundary condition: false
initial amount: NaN
name: arachidonate
is: SBO:0000247
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:32395

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_be2caba8_8861_434e_a99f_d9983bac0aaa
boundary condition: true
is encoded by: hsa:6240
initial amount: NaN
name: RRM1
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P23921
initial concentration: NaN

metaR MI1PP
name: myo-inositol 1-phosphatase
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_bf22b3ab_2f3e_4bd5_8922_b7da7aae8876
is: P09960
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4048
initial amount: NaN
boundary condition: true
name: LTA4H
is: SBO:0000252

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR DURIt
fast: false
product: MODEL1310110018#
name: deoxyuridine transport via diffusion
reactant: MODEL1310110018#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_4daa7047_827e_4ea9_9720_76461c1ba607
has only substance units: false
name: SRM
is: SBO:0000252
is: P19623
initial concentration: NaN
is encoded by: hsa:6723
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaM acac c
is: SBO:0000247
name: acetoacetate
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: HMDB00060
is: CHEBI:13705
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e69c4e4c_d0c2_4d54_9a8e_c7f84377ae37
is: A7E2E0
has only substance units: false
initial concentration: NaN
name: PIK3CD
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5293
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_093a070d_82cd_4c3b_9376_0b24d6f48f13
is: P04040
is: SBO:0000252
is encoded by: hsa:847
name: CAT
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_b91fd0a4_773e_48eb_a715_4038d7f12793
has only substance units: false
name: ANPEP
initial concentration: NaN
is encoded by: hsa:290
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: Q59E93

metaM ksii core2 deg6 l
has only substance units: false
constant: false
is: CHEBI:12936
is: HMDB00143
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6
type: Species
initial amount: NaN
is: SBO:0000247

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
has only substance units: false
is: CHEBI:15428
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: glycine
initial amount: NaN

metaR NACHEX18ly
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
type: Reaction
is: SBO:0000176

metaR RE3367E
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
reversible: false
reactant: MODEL1310110018#
name: RE3367
is described by: ECO:0000000

metaR CSPG Btly
name: chondroitin sulfate B transport, extracellular to lysosome
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110018#
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110018#

metaM tststerone r
constant: false
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:17347

metaR ETOHt
is: SBO:0000185
name: ethanol reversible transport
reversible: true
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c68df3f2_d37d_4895_9edd_bfc8d730072d
name: ME2
is: P23368
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4200
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_24ce64d0_2bd7_41dd_8aaa_a0c7eb1d68e0
has only substance units: false
type: Species
name: IMPDH2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:3615
initial amount: NaN
initial concentration: NaN
is: P12268

metaR ASNTHRNaEx
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_bbc2e23f_547c_4b22_92c6_90f1c637ae0d
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9Y233
type: Species
is encoded by: hsa:10846
boundary condition: true
initial concentration: NaN
name: PDE10A

metaM 2oxoadp m
type: Species
is: CHEBI:57499
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00225
name: 2-oxoadipate(2-)
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR r0801
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
product: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_09ffd8e1_ea9e_4b27_a604_24eb129b5f7c
initial amount: NaN
is: SBO:0000252
name: ENTPD4
boundary condition: true
initial concentration: NaN
type: Species
is: Q9Y227
constant: false
has only substance units: false
is encoded by: hsa:9583

metaR RDH2a
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (9-cis,NADPH)
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_50779452_d1b1_4a9d_b8e6_77ed5841d428
is: P50747
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3141
name: HLCS
boundary condition: true
type: Species
initial amount: NaN

metaR ALAASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b1d99864_47ab_4c6f_a717_35c8b5dd6996
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4715
type: Species
is: Q9Y6M9
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFB9
initial amount: NaN

metaM etfox m
notes: FORMULA: R CHARGE: 0
constant: false
initial concentration: 1.0
name: Electron transfer flavoprotein oxidized
is: CHEBI:16469
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00151
is: SBO:0000247
type: Species

metaM dadp n
is: CHEBI:57667
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01508
name: dADP(3-)
constant: false
type: Species
is: SBO:0000247

metaM Lpipecol x
is: CHEBI:30913
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
boundary condition: false
name: L-pipecolic acid
is: HMDB00716
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM crtsl r
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17650
is: SBO:0000247
initial amount: NaN
name: cortisol
type: Species
is: HMDB00063
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735

metaM estradiol r
is: CHEBI:16469
initial amount: NaN
is: HMDB00151
type: Species
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
name: estradiol
boundary condition: false
constant: false
has only substance units: false

metaR NACHEX21ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110018#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_4406fd2a_06ca_4b9a_b401_ecc05960afdf
type: Species
name: FOLR1
constant: false
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_4021dd93_31ad_49dd_9bce_3c671eb9aa37
is: G3V0F6
is: SBO:0000252
type: Species
is encoded by: hsa:8525
has only substance units: false
name: DGKZ
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR r2130
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110018#

metaR r0728
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176

metaR ONPTHLte
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
fast: false
name: xenobiotic transport

metaR PYNP2r
fast: false
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_9a8a2bda_9906_45d5_8a49_6bf89fb5b91b
type: Species
is encoded by: hsa:205
initial concentration: NaN
has only substance units: false
boundary condition: true
name: AK4
is: SBO:0000252
initial amount: NaN
constant: false

metaM dcsptn1 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB13123
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
is: http://identifiers.org/pubchem.compound/5282848

metaM glu5sa m
constant: false
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: C01165
boundary condition: false
initial concentration: 1.0
is: CHEBI:17232
is: HMDB02104
name: L-Glutamate 5-semialdehyde
type: Species
has only substance units: false
initial amount: NaN

metaR G14T6g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110018#_eaed13c4_33d8_47b9_8129_1261cbccb98d
initial amount: NaN
is: B3KT84
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:195814
has only substance units: false
name: SDR16C5
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_926bf42a_15cf_487b_ba12_c5e25743fbbe
is: SBO:0000252
is encoded by: hsa:2974
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: GUCY1B2
type: Species

metaR r2131
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110018#
is: SBO:0000185

metaR LEUKTRE4t
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: leukotriene E4 transport

metaM leuktrD4 e
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
has only substance units: false
is: HMDB03080
name: Leukotriene D4

http://identifiers.org/biomodels.db/MODEL1310110018#_788dc4ff_2784_4017_bc2e_9c514e367c8d
boundary condition: true
is encoded by: hsa:57665
has only substance units: false
is: SBO:0000252
is: Q9HBH5
initial amount: NaN
initial concentration: NaN
constant: false
name: RDH14
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_82c1625d_77f2_44fc_9ad4_d76ed3a613ad
name: ALDH1B1
type: Species
constant: false
is: P30837
is: SBO:0000252
is encoded by: hsa:219
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_9b533120_5283_4557_b0c5_c1fcf24eb51a
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5313
initial concentration: NaN
name: PKLR

http://identifiers.org/biomodels.db/MODEL1310110018#_b6f95957_9d57_49c2_babc_64acad5f791d
is: SBO:0000252
type: Species
is encoded by: hsa:79837
has only substance units: false
initial amount: NaN
is: B3KQV3
constant: false
name: PIP4K2C
boundary condition: true
initial concentration: NaN

metaR IDOAASE4ly
is described by: ECO:0000000
type: Reaction
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110018#
reversible: false
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110018#

metaM ksi deg40 l
name: keratan sulfate I, degradation product 40
is: CHEBI:12936
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
has only substance units: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false

metaM amp m
is: SBO:0000247
boundary condition: false
is: HMDB00045
initial concentration: 1.0
name: AMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:456215
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ddcb83b1_e32e_42a3_8ecc_137b9d364465
boundary condition: true
initial concentration: NaN
name: _M68895_1_c
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:M68895
initial amount: NaN

metaM m2emgacpail hs r
is: C00080
is: CHEBI:24636
boundary condition: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/3380
constant: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_d4130961_59d0_458f_bd19_5d678bed0954
initial amount: NaN
type: Species
is: O43677
has only substance units: false
constant: false
name: NDUFC1
is: SBO:0000252
is encoded by: hsa:4717
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_3fb20e15_e2cf_40d6_ba62_277894365d62
constant: false
initial amount: NaN
type: Species
name: NAGLU
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P54802
has only substance units: false
is encoded by: hsa:4669

metaR r2132
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d6066944_fb60_4545_9dd7_124b26fd84c3
is encoded by: hsa:686
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P43251
name: BTD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_00ae2b19_6c8b_4be1_a40b_9c6a0606d8ad
type: Species
is encoded by: hsa:2629
name: GBA
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_1b5b4bc2_5ff6_468f_bfa9_db6c676c0a00
name: ST3GAL1
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6482
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_f93511cc_152a_44bc_8b55_245cdba6dbe8
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:286016
name: TPI1P2
type: Species
is: SBO:0000252

metaR GCC2bim
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_5e2fe7d7_13ad_4ff2_a946_1302f79ae717
initial amount: NaN
is encoded by: hsa:221823
boundary condition: true
name: PRPS1L1
is: SBO:0000252
initial concentration: NaN
is: P21108
has only substance units: false
type: Species
constant: false

metaR APOC LYS BTNPm
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110018#
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false

metaR TETPENT6t
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_b689c26b_e525_48dc_94a2_9de40068d9f7
constant: false
initial concentration: NaN
is encoded by: hsa:18
is: SBO:0000252
name: ABAT
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaM dcsptn1 c
is: HMDB13123
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
initial concentration: 1.0
constant: false

metaM 3hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02288
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
boundary condition: false

metaM HC00361 c
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: CHEBI:58335
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0

metaM dtmp e
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: dTMP(2-)
is: HMDB01227
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110018#_520cbf67_377e_4c51_bad2_34368bd44559
has only substance units: false
name: KDSR
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q06136
is encoded by: hsa:2531

metaR GLYtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
reversible: true
is: SBO:0000185
name: glycine passive transport to mitochondria

metaR RE3626M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3626
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#

metaM hcoumarin e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:27510
constant: false
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
has only substance units: false
name: umbelliferone
is: SBO:0000247
is: C09315

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r2401
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaM dadp m
name: dADP(3-)
is: HMDB01508
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57667

http://identifiers.org/biomodels.db/MODEL1310110018#_cb37cbbd_9bff_41d5_ad15_70aeb0c53c93
name: GPX7
has only substance units: false
is encoded by: hsa:2882
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q96SL4
type: Species
constant: false

metaM sphs1p r
is: SBO:0000247
is: HMDB00277
initial concentration: 1.0
constant: false
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
type: Species
is: CHEBI:60119
boundary condition: false
has only substance units: false

metaR TPI
kinetic law: MODEL1310110018#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.1
modifier: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
reactant: MODEL1310110018#
type: Reaction
name: triose-phosphate isomerase

metaM 5forthf c
has only substance units: false
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: C00664
is: HMDB01534
constant: false

metaM mmcoa S m
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02310
is: CHEBI:57327
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
name: (S)-methylmalonyl-CoA(5-)
is: SBO:0000247
has only substance units: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM coa c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3312
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false
type: Species
is: HMDB01423
name: Coenzyme A
boundary condition: false
is: C00010
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_40d22307_9cb7_4ae7_80ce_f98e12114e90
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: MCCC1
is encoded by: hsa:56922
boundary condition: true
is: Q96RQ3

http://identifiers.org/biomodels.db/MODEL1310110018#_23c598f8_6fb7_4b70_b3fb_f86e24bd274a
has only substance units: false
is: P04062
boundary condition: true
constant: false
type: Species
name: GBA
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2629
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_f0122942_f4a7_4655_b703_d17c4fc8d1c1
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _AA177072_1_c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110018#_dcf8c02e_10ed_4191_8dc8_ec4a79f50f5c
name: FASN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P49327
initial amount: NaN
is encoded by: hsa:2194
boundary condition: true
has only substance units: false

metaR NDPK3m
type: Reaction
reversible: true
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110018#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110018#

metaR RE2973C
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1

metaM dtmp c
is: HMDB01227
name: dTMP
is: CHEBI:26999
is: SBO:0000247
initial amount: NaN
is: C00364
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110018#_baf3c551_b854_407e_adc9_909b1624713b
is encoded by: hsa:8566
is: O00764
boundary condition: true
constant: false
type: Species
name: PDXK
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR MMSAD3m
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
reversible: false
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.27
reactant: MODEL1310110018#
fast: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_dada5533_139b_46fc_a800_c5e6cc3bdbe6
type: Species
is encoded by: hsa:375056
name: MIA3
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q5JRA6

http://identifiers.org/biomodels.db/MODEL1310110018#_cd020409_d6a4_4b1e_a337_d9618a2e9eb2
has only substance units: false
name: ALDH6A1
initial concentration: NaN
initial amount: NaN
type: Species
is: Q02252
is: SBO:0000252
is encoded by: hsa:4329
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b2e371b8_3ce5_4a07_89fc_60885c2095ab
is: P21589
constant: false
name: NT5E
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4907
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_6f336c80_88df_47f3_8e1e_35f5b3c38942
is: E9KL44
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3030
has only substance units: false
constant: false
type: Species
name: HADHA

metaR NDPK3n
is described by: ECO:0000304
reactant: MODEL1310110018#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a0e20b14_7b3a_4f06_b1fb_52c8d80b9aaa
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:121278
has only substance units: false
is: Q8IWU9
name: TPH2
initial amount: NaN
type: Species

metaR r2099
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction

metaR TAGt
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
name: triacylglycerol transport

metaR GALU
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
product: MODEL1310110018#
is described by: ECO:0000134
reversible: true
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110018#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.7.9
kinetic law: MODEL1310110018#

metaM pydam c
has only substance units: false
is: SBO:0000247
is: HMDB01431
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
constant: false
type: Species
is: C00534
name: Pyridoxamine
boundary condition: false
is: CHEBI:57761

metaR LINOFATPtc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r2137
fast: false
reversible: true
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185

metaR FAOXC241C221x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaM hs deg16 l
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial amount: NaN
is: SBO:0000247
is: CHEBI:21338
is: HMDB02704
type: Species
boundary condition: false
name: heparan sulfate, degradation product 16

metaR r0809
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110018#
name: Facilitated diffusion
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reversible: true
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_154a35e2_3e11_4b79_b2cf_4424653a54f5
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AA526438
has only substance units: false
is: SBO:0000252
constant: false
name: _AA526438_1_c
boundary condition: true

metaM ksi deg19 l
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
has only substance units: false
is: HMDB00812
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 19
constant: false
is: CHEBI:16953

metaR PYRt2m
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
type: Reaction
reversible: true
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

metaR CHOLt4
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110018#
name: choline, sodium cotransport
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

metaM mal L c
boundary condition: false
initial concentration: 1.0
is: HMDB00156
name: (S)-malate(2-)
initial amount: NaN
has only substance units: false
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
type: Species

metaR r2098
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_37424e78_6439_474d_a4ad_786a66882c57
name: NT5M
is: Q9NPB1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:56953
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR CYTK4n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_3ddeae6d_f81a_4e08_8a99_080f021f531d
initial concentration: NaN
type: Species
is: P50135
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: HNMT
is encoded by: hsa:3176
constant: false

metaM Lcystin e
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial concentration: 1.0
is: HMDB00192
has only substance units: false
boundary condition: false
constant: false
name: L-cystine
initial amount: NaN
is: CHEBI:16283
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_1da6cf95_6e04_4ccc_976b_90430ba94230
name: _83530_1_c
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:83530

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_297d45eb_1273_4563_aafd_faef9c5932d4
has only substance units: false
is encoded by: hsa:6535
name: SLC6A8
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: B4DIA3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_475c5531_6599_43f1_acc8_2942d58a4e0a
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: _H45672_1_m
is encoded by: hsa:H45672
is: SBO:0000252

metaM dmnoncrn m
has only substance units: false
constant: false
is: HMDB06202
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
name: 4,8 dimethylnonanoyl carnitine
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_22e61f5f_2bbb_420d_a94f_9728e5598961
is encoded by: hsa:28976
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: Q9H845
initial concentration: NaN
initial amount: NaN
name: ACAD9

metaR PItg
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110018#

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR NACHEX8ly
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110018#_82f75995_14dd_4a4a_8a2d_02392d52f6a7
type: Species
is: SBO:0000252
is: Q99624
is encoded by: hsa:10991
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: SLC38A3

metaR r2097
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR SBTR
kinetic law: MODEL1310110018#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
name: D-sorbitol reductase
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
reversible: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR r0509
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110018#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
product: MODEL1310110018#
reversible: false

metaM coa g
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: coenzyme A(4-)
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57287
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_0c080a10_40ac_4cad_885b_31614d535c6c
initial concentration: NaN
is: P22303
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACHE
type: Species
is encoded by: hsa:43

metaM ocdcea r
initial concentration: 1.0
is: C00712
constant: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

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name: _AA854479_1_m
has only substance units: false
is encoded by: hsa:AA854479
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_0153d67f_40a3_47ec_9590_b26d5ef94f7c
is: P37287
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:5277
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PIGA
constant: false

metaR r2139
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_40feb3c9_1eb2_47ae_b422_2e8a6af221f9
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9UHK6
is encoded by: hsa:23600
has only substance units: false
initial amount: NaN
boundary condition: true
name: AMACR

metaR r2096
type: Reaction
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110018#_0f8ad99f_3be5_40b9_9182_3f87e3125f98
initial concentration: NaN
type: Species
is encoded by: hsa:5153
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q7Z364
name: PDE1B
boundary condition: true
constant: false

metaR GALT
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110018#
is described by: ECO:0000000
name: galactose-1-phosphate uridylyltransferase
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:

metaR S6T13g
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110018#
reversible: false
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM hcoumarin c
boundary condition: false
is: C09315
initial amount: NaN
is: CHEBI:27510
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
has only substance units: false
name: umbelliferone
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_ba168714_23e8_4b84_b33f_f7052ef7ca48
is: SBO:0000252
name: NDUFS2
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4720
boundary condition: true
is: B7Z792
initial amount: NaN
type: Species

metaM Lcystin c
initial concentration: 1.0
constant: false
is: HMDB00192
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16283
initial amount: NaN
boundary condition: false
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110018#_a5feb2f6_645a_436f_be0d_69ff4532dba4
type: Species
is encoded by: hsa:79053
constant: false
boundary condition: true
initial concentration: NaN
name: ALG8
has only substance units: false
initial amount: NaN
is: A6NDW6
is: SBO:0000252

metaR ASPNATm
type: Reaction
reversible: false
name: aspartate N-acetyltransferase, mitochondrial
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110018#_83a7aed1_e918_4fae_af5a_11d6e1c4ec6f
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110018#_b87f7888_7c38_442d_9f16_7fc83103a8ef
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
is encoded by: hsa:5279
has part: P57054
has part: B2RAU6
is encoded by: hsa:5277
type: Species
has only substance units: false
is encoded by: hsa:51227
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9091
boundary condition: true

metaM glcur r
has only substance units: false
boundary condition: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:15748
type: Species
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110018#_d9081e1e_dd65_440e_8018_00eb70e549f4
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7086
name: TKT
is: E7EPA7
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM chito2pdol U c
is: SBO:0000247
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
boundary condition: false
is: CHEBI:12427
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20

metaR PHEACGLNt
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
name: PHEACGLN extracellular transport via diffusion
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110018#

metaM dtmp m
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
is: CHEBI:26999
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dTMP
has only substance units: false
is: HMDB01227

metaM s2l2n2m2masn l
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00174
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:18287
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
name: de-Fuc form of PA6

metaR 5AOPtm
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
is: SBO:0000185
product: MODEL1310110018#
fast: false
name: 5-Aminolevulinate mitochondrial transport

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR FACOAL226
product: MODEL1310110018#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110018#_c22a93d0_c147_4a95_b333_43ca3d7454a7
is: Q3KT79
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:23600
name: AMACR
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_b0a2bb03_6248_443f_aefc_30084feb6b89
has only substance units: false
constant: false
is: P43353
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: ALDH3B1
is encoded by: hsa:221
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_330747a6_5a15_4611_ab02_2d8887f1b730
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: QPRT
is encoded by: hsa:23475
constant: false
is: Q15274
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_55110c04_bbea_425c_a1d9_7123d07e4139
is encoded by: hsa:6549
boundary condition: true
name: SLC9A2
initial amount: NaN
is: SBO:0000252
is: Q9UBY0
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR q10tm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
is described by: ECO:0000134
name: transport of ubiquinone into mitochondria
reversible: true
reactant: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_f5a74ad2_5206_4b4f_95c2_309bb6b997ce
initial concentration: NaN
type: Species
is: P17707
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:262
boundary condition: true
name: AMD1

metaR r2514
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
name: Utilized transport
product: MODEL1310110018#

metaR EX adp
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_bf800446_03a4_4362_b787_57ec2087e515
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2538
initial concentration: NaN
is: P35575
name: G6PC
constant: false
boundary condition: true
is: SBO:0000252

metaM n2m2mn l
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: HMDB00939
has only substance units: false
is: CHEBI:16680

http://identifiers.org/biomodels.db/MODEL1310110018#_a73d1b07_1782_4230_b275_fad257330f97
is: Q96Q11
boundary condition: true
constant: false
name: TRNT1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51095
initial amount: NaN
initial concentration: NaN

metaM arachd c
is: SBO:0000247
is: HMDB01043
constant: false
name: arachidonate
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32395
has only substance units: false

metaR RE1836X
product: MODEL1310110018#
reversible: true
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
name: RE1836
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR EX debrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: debrisoquine exchange
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM dadp c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
is: CHEBI:57667
is: HMDB01508
is: C00206
constant: false
type: Species
name: dADP
is: SBO:0000247

metaM mal L e
name: (S)-malate(2-)
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00156
is: CHEBI:15589
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false

metaM amp x
initial concentration: 1.0
is: HMDB00045
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
has only substance units: false
boundary condition: false
is: C00020
name: AMP
initial amount: NaN

metaM eicostetcoa c
is: SBO:0000247
boundary condition: false
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C16164

http://identifiers.org/biomodels.db/MODEL1310110018#_d96a6ad4_ff17_4ae6_ab4e_7ec7beeff9e2
initial concentration: NaN
is encoded by: hsa:171425
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q8N0X4
has only substance units: false
name: CLYBL

http://identifiers.org/biomodels.db/MODEL1310110018#_5131cad6_658f_478f_9fba_829910a615bf
boundary condition: true
initial amount: NaN
is encoded by: hsa:8527
has only substance units: false
constant: false
type: Species
name: DGKD
initial concentration: NaN
is: SBO:0000252

metaR FACOAL224
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110018#
fast: false
type: Reaction

metaR ARABR
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
name: arabinose reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110018#
type: Reaction

metaR LNLCCRNt
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000269
kinetic law: MODEL1310110018#
fast: false
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d8d9c44e_aeff_40b4_af6e_e9bf7c78d753
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: SLC37A4
is: A8K0S7
constant: false
is encoded by: hsa:2542

metaR CRNt
reactant: MODEL1310110018#
name: L-carnitine reversible transport
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
type: Reaction
reversible: true
modifier: MODEL1310110018#

metaM mal L m
is: CHEBI:15589
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (S)-malate(2-)
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM 2dr1p c
is: CHEBI:58576
name: 2-Deoxy-D-ribose 1-phosphate
is: C00672
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
is: HMDB01351
has only substance units: false
type: Species

metaM coa m
boundary condition: false
name: Coenzyme A
is: CHEBI:57287
initial concentration: 1.0
is: SBO:0000247
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
type: Species
has only substance units: false
is: HMDB01423
initial amount: NaN

metaM arachd e
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: HMDB01043
name: arachidonate
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:32395

http://identifiers.org/biomodels.db/MODEL1310110018#_e38a58f2_2dc1_4466_b056_ea8b3fc9523b
initial amount: NaN
has only substance units: false
is: Q9BWD1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:39
name: ACAT2

http://identifiers.org/biomodels.db/MODEL1310110018#_8af1556f_beb0_4aca_958d_989573df0c1c
has only substance units: false
constant: false
is encoded by: hsa:126328
boundary condition: true
is: C9JT23
initial amount: NaN
name: NDUFA11
initial concentration: NaN
type: Species
is: SBO:0000252

metaM thmpp m
constant: false
has only substance units: false
is: CHEBI:45931
is: SBO:0000247
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01372
name: Thiamine diphosphate
type: Species

metaM dd3coa x
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 3-dodecenoylcoa
is: HMDB04257
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4

metaM 4abut m
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
constant: false
is: C00334
boundary condition: false
is: CHEBI:16865
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c8ff9cb7_d829_43df_b4db_d7a9b2bea3ef
has only substance units: false
boundary condition: true
name: B3GNT2
is: SBO:0000252
is encoded by: hsa:10678
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM ksi pre21 g
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 21
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: CHEBI:2504
is: HMDB06552
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM xol7ah c
is: CHEBI:2290
is: HMDB06892
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_a932b91f_4831_408e_84c4_e34cb6406039
constant: false
type: Species
is encoded by: hsa:22305
has only substance units: false
initial concentration: NaN
name: _22305_2_c
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR CSPG Etly
fast: false
name: chondroitin sulfate E transport, extracellular to lysosome
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_3e87e7ea_5990_479d_861d_cc8849e196e1
is encoded by: hsa:5476
type: Species
initial amount: NaN
is: P10619
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CTSA
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_c4abd444_2b38_4c63_bd8c_0b97e304be81
is encoded by: hsa:5230
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P00558
type: Species
name: PGK1
initial concentration: NaN

metaR RIBt
name: ribose transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110018#
type: Reaction
fast: false
reversible: true

metaR FAOXC101m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM acac m
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
is: SBO:0000247
constant: false
is: CHEBI:13705
is: HMDB00060

metaR r2511
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaR r0504
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176

metaM 4abut n
is: C00334
initial amount: NaN
has only substance units: false
boundary condition: false
name: 4-Aminobutanoate
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
type: Species
is: HMDB00112

metaM lneldccrn m
constant: false
name: Linoelaidyl carnitine
is: HMDB06461
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247

metaM ksi deg4 l
name: keratan sulfate I, degradation product 4
is: HMDB00868
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57737
is: SBO:0000247

metaM ksi deg23 l
constant: false
name: keratan sulfate I, degradation product 23
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143

metaM glcur l
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: CHEBI:15748
type: Species
initial amount: NaN
has only substance units: false
name: D-glucuronate
is: HMDB00127
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_070816ef_b6da_40cd_ac57_957daaeccd2b
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2571
is: Q8IVA8
name: GAD1
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM HC01412 m
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: trans-tetradec-2-enoyl-CoA(4-)
is: CHEBI:61405
has only substance units: false
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273

metaR RE2660N
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
name: RE2660
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_2e76a93a_150c_4f3f_a1d3_c698a75123f5
is encoded by: hsa:57786
type: Species
is: Q9NYW8
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: RBAK
has only substance units: false

metaR FK
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#
name: Fucokinase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.52
type: Reaction
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR HIStN1
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
reversible: true
name: Histidine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110018#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110018#

metaR RTOTAL2t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true
name: RTOTAL2 transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR GALK
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
name: galactokinase
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.6
is version of: http://identifiers.org/ec-code/2.7.1.157
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_6194f635_18ab_4b39_a896_a15f04f8a0c5
has only substance units: false
constant: false
is: B4E097
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GALT
type: Species
is encoded by: hsa:2592

metaR PYRt2r
reactant: MODEL1310110018#
reversible: true
fast: false
product: MODEL1310110018#
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_fe7b4fa9_ad36_46ca_9b29_ae02c038b4c2
has only substance units: false
is encoded by: hsa:377841
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: ENTPD8
is: Q5MY95
boundary condition: true
is: SBO:0000252

metaR SR5ARr
type: Reaction
kinetic law: MODEL1310110018#
fast: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reversible: false
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is version of: http://identifiers.org/ec-code/1.3.99.5
modifier: MODEL1310110018#
is described by: ECO:0000134

metaM 4mzym int2 r
is: SBO:0000247
name: 4-Methylzymosterol intermediate 2
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB06838

http://identifiers.org/biomodels.db/MODEL1310110018#_eb6a95ad_2598_4cfd_bcfa_3410ccb51ea5
boundary condition: true
type: Species
is encoded by: hsa:26289
is: SBO:0000252
name: AK5
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM dolp U r
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
name: dolichyl phosphate(2-)
type: Species
constant: false
is: CHEBI:57683
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR INSt4
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: inosine transport in via sodium symport
type: Reaction
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
is: SBO:0000185

metaR UMPK2n
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000176
name: UMP kinase (CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#

metaM 7thf e
initial amount: NaN
is: HMDB06559
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
boundary condition: false
name: heptaglutamyl folate (THF)
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_983f70a1_389d_483d_8034_6046bee6cc8f
initial concentration: NaN
name: DOLPP1
has only substance units: false
is: Q86YN1
initial amount: NaN
is encoded by: hsa:57171
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaM hs deg3 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
constant: false
is: CHEBI:16126
type: Species
has only substance units: false
name: heparan sulfate, degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110018#_ec2aa932_c88e_4c1d_bf3d_7f3851c42c17
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PANK3
is encoded by: hsa:79646
type: Species
is: Q9H999

http://identifiers.org/biomodels.db/MODEL1310110018#_67a60282_d96c_4512_9e71_c125875c2c51
initial amount: NaN
is encoded by: hsa:54407
is: Q96QD8
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC38A2
type: Species
boundary condition: true

metaM udpg c
is: HMDB00286
is: SBO:0000247
is: CHEBI:58367
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00029
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
name: UDPglucose
type: Species

metaR FUMm
name: fumarase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110018#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000134

metaM coa n
is: HMDB01423
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
name: coenzyme A(4-)
initial concentration: 1.0
constant: false
is: CHEBI:57287
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_0cfe5921_5238_497f_8218_94a965f1c094
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: _AI697028_1_m
boundary condition: true
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110018#_5f035cb8_d9c6_45d7_b7bd_933aa5a3721f
type: Species
is: Q8TB61
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:347734
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC35B2

http://identifiers.org/biomodels.db/MODEL1310110018#_234814b1_c97e_4328_bd85_d3e65a10d695
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: SLC16A10
is: Q8TF71
is encoded by: hsa:117247
boundary condition: true
is: SBO:0000252

metaR r0502
kinetic law: MODEL1310110018#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.113
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110018#
fast: false
type: Reaction
modifier: MODEL1310110018#

metaR PItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
product: MODEL1310110018#
name: phosphate transport, nuclear
is: SBO:0000185
reactant: MODEL1310110018#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaM coa r
type: Species
name: Coenzyme A
constant: false
is: CHEBI:57287
is: HMDB01423
is: C00010
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR CTPtn
type: Reaction
name: CTP diffusion in nucleus
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#

metaM ocdcea e
is: C00712
constant: false
is: HMDB00207
has only substance units: false
is: CHEBI:0
name: octadecenoate (n-C18:1)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
initial amount: NaN
type: Species

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a42e1eda_18ad_4e23_b056_dee6ffa4bcd4
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: MANBA
is encoded by: hsa:4126
is: SBO:0000252
boundary condition: true
is: O00462

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
name: RE0344
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110018#
fast: false

metaR GALSIDEtg
name: galactocerebroside intracellular transport
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaM ksi pre32 g
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 32
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_dbb0452d_07e3_46ce_b00d_7840f0373a79
is encoded by: hsa:1349
boundary condition: true
type: Species
has only substance units: false
is: P24311
initial amount: NaN
name: COX7B
is: SBO:0000252
initial concentration: NaN
constant: false

metaR O2tn
name: O2 nuclear transport
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110018#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176

metaM ksii core4 deg1 l
is: HMDB00868
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
initial concentration: 1.0
is: CHEBI:57737
name: keratan sulfate II (core 4-linked), degradation product 1
initial amount: NaN
constant: false
has only substance units: false

metaM dhcholoylcoa x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:27393
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: SBO:0000247
is: HMDB06895
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

metaM 3hibutcoa m
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
boundary condition: false
is: CHEBI:28259
is: HMDB01052
initial concentration: 1.0

metaR MDHx
reversible: true
is described by: ECO:0000134
product: MODEL1310110018#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: malate dehydrogenase, peroxisomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_628d2769_4c92_450a_837e_2427e7bf31ad
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:9856
boundary condition: true
has only substance units: false
is: F5H123
initial concentration: NaN
name: DYLX2

http://identifiers.org/biomodels.db/MODEL1310110018#_fa0e79bd_4fb0_4a90_aaf4_2bb1493f38e9
name: GUCY2C
is encoded by: hsa:2984
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P25092
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d14c376b_69ee_4989_974c_4ed6802bff04
name: HAGHL
boundary condition: true
has only substance units: false
is encoded by: hsa:84264
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6PII5
initial concentration: NaN
type: Species

metaR O2tm
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: O2 transport (diffusion)
reactant: MODEL1310110018#

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR B3GNT39g
reversible: false
reactant: MODEL1310110018#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#

metaM bamppald c
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: http://identifiers.org/pubchem.compound/7975
is: HMDB01106
initial amount: NaN
has only substance units: false
constant: false
name: beta-Aminopropion aldehyde
boundary condition: false
is: SBO:0000247
is: C05665
initial concentration: 1.0
type: Species

metaM ocdcea c
initial amount: NaN
constant: false
is: HMDB00207
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
is: C00712
is: CHEBI:0
type: Species
has only substance units: false
initial concentration: 1.0
name: octadecenoate (n-C18:1)

metaR AG13T6g
product: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaR DPMVDc
type: Reaction
modifier: MODEL1310110018#
name: diphosphomevalonate decarboxylase, cytosol
fast: false
is: SBO:0000176
product: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.33
is described by: ECO:0000134
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.

http://identifiers.org/biomodels.db/MODEL1310110018#_a88ffb0e_4137_437a_8bfa_cc5f7335de90
has only substance units: false
type: Species
is: P30838
constant: false
initial amount: NaN
is encoded by: hsa:218
name: ALDH3A1
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_1698994e_cca2_400f_a703_c178d79fc44f
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2987
name: GUK1
is: Q16774
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_516ffda2_3fd7_4fd6_b411_c5edc2cb6d09
name: _LOC727762_1_m
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:LOC727762
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_db6ee742_cc54_4585_9378_12707794aa07
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P54709
type: Species
initial concentration: NaN
is encoded by: hsa:483
constant: false
name: ATP1B3

metaM CE2433 m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: CHEBI:57795
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
is: SBO:0000247
type: Species

metaR TSULt4 3
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000185
name: thiosulfate transport via sodium symport
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false

metaM nrvnccoa c
boundary condition: false
is: C16532
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: nervonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110018#_77c9f2d3_0db1_441b_9708_12bf71bcc01b
is encoded by: hsa:57194
has only substance units: false
is: O60312
type: Species
name: ATP10A
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0603
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.12
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reversible: true
kinetic law: MODEL1310110018#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
product: MODEL1310110018#

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
boundary condition: false
type: Species
has only substance units: false
is: HMDB01163
constant: false
initial concentration: 1.0
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_ae94fd6b_3dae_44ff_a588_c69c6bc3b6e2
initial amount: NaN
initial concentration: NaN
type: Species
name: FUT8
boundary condition: true
is: A8K8P8
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2530

http://identifiers.org/biomodels.db/MODEL1310110018#_933d7621_773b_44b8_b1c7_46a7037e1cf0
name: GPX5
boundary condition: true
type: Species
is encoded by: hsa:2880
is: O75715
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_72be1917_507b_4a96_884f_0860596cba0e
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4882
boundary condition: true
name: NPR2

metaR NACHEX22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reversible: false

metaR HMGCOAtm
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
type: Reaction
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD

metaM glcur e
boundary condition: false
is: CHEBI:15748
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_1596df74_1dcc_4bfa_aa0b_b746598b4b36
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: O00443
initial concentration: NaN
name: PIK3C2A
is encoded by: hsa:5286
boundary condition: true
type: Species

metaM ddcacoa c
type: Species
constant: false
is: C01832
initial amount: NaN
is: HMDB03571
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_0f8270b3_1e3c_4aff_a2f2_a2ef720e8a6e
boundary condition: true
is: SBO:0000252
is: O43678
name: NDUFA2
has only substance units: false
initial amount: NaN
is encoded by: hsa:4695
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_3f6bb30e_60da_46d4_a55b_c7b592295e24
is encoded by: hsa:7372
name: UMPS
is: SBO:0000252
is: A8K5J1
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR DNDPt41m
reactant: MODEL1310110018#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
type: Reaction
fast: false
name: dUTP transport via dCDP antiport
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_14407984_ea98_48c7_8b64_d14cff3af820
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:2618
type: Species
is: Q59HH3
name: GART
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR CBR2
kinetic law: MODEL1310110018#
name: Carbonyl reductase [NADPH] 1
is version of: http://identifiers.org/ec-code/1.1.1.189
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_2ce93f95_a7c1_40cd_951d_f005c99fa08e
is: SBO:0000252
is encoded by: hsa:131669
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q68CJ7
boundary condition: true
constant: false
name: UROC1

http://identifiers.org/biomodels.db/MODEL1310110018#_9ab3f714_fa66_46e8_ab75_620ea49ae02e
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: FUCA2
has only substance units: false
is encoded by: hsa:2519
is: Q9BTY2
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_85fc96de_71c7_4676_9855_7eec8a0bf824
name: GGT1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2678

metaR RTOTALt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
name: RTOTAL transport
type: Reaction
kinetic law: MODEL1310110018#

metaR RE2799C
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000

metaM retn e
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
name: all-trans-retinoate
constant: false
is: CHEBI:35291
initial concentration: 1.0
is: HMDB01852
has only substance units: false

metaM mercppyr c
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
has only substance units: false
is: HMDB01368
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57678
is: SBO:0000247

metaR AKGMALtm
product: MODEL1310110018#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_e11f3200_9e82_4ee2_8e06_d030a3ad0855
type: Species
constant: false
is encoded by: hsa:54539
has only substance units: false
name: NDUFB11
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9NX14
initial amount: NaN

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR SERHL
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
fast: false
name: L-Serine hydro-lyase
is described by: ECO:0000269
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.3.1.17
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_eaf71deb_7c12_4efe_99f7_56bdf21320be
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:7264
initial concentration: NaN
is: Q13630
is: SBO:0000252
name: TSTA3

http://identifiers.org/biomodels.db/MODEL1310110018#_eae25823_5ddf_47eb_bc40_202507fa834d
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: PROSC
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11212
type: Species
is: O94903

metaM retinal cis 9 c
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: SBO:0000247
initial amount: NaN
is: HMDB01358
initial concentration: 1.0
is: CHEBI:17898

http://identifiers.org/biomodels.db/MODEL1310110018#_32abd147_0be0_48c8_95a3_a7599e1c4ea1
is encoded by: hsa:64077
initial concentration: NaN
has only substance units: false
is: Q9H008
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: LHPP
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_4576fe87_049f_4e73_806d_eba8b2a909b7
constant: false
is encoded by: hsa:51557
is: Q5TDP6
type: Species
initial concentration: NaN
boundary condition: true
name: LGSN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GLNCYSNaEx
fast: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
reversible: false
modifier: MODEL1310110018#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM pydxn c
is: C00314
initial amount: NaN
boundary condition: false
is: CHEBI:16709
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: HMDB00239
has only substance units: false
initial concentration: 1.0
name: Pyridoxine

metaM xoldiolone r
has only substance units: false
is: CHEBI:28477
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02197
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR DGSNt
product: MODEL1310110018#
name: deoyguanosine transport via diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_c521a249_fd62_4ff3_bfae_9974579e56ad
is: SBO:0000252
is encoded by: hsa:4715
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NDUFB9
has only substance units: false
is: Q9Y6M9

metaR NACHEX26ly
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110018#

metaM ksi pre36 g
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial amount: NaN
is: CHEBI:28067
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 36
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR RE0583C
reactant: MODEL1310110018#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110018#
name: RE0583
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:

metaR PIt7
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
fast: false
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaM 3dsphgn c
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58299
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
has only substance units: false
is: HMDB01480
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
boundary condition: false
type: Species

metaM sarcs m
is: CHEBI:15611
constant: false
has only substance units: false
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
type: Species
is: C00213
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Sarcosine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_35c81546_b0ff_4d1c_ae17_2ccc883339b7
is: P48764
name: SLC9A3
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6550
constant: false

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
name: dCMP
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57566
initial amount: NaN
is: C00239
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_608c5f34_176e_4828_9a88_8a0e6e72c145
is: Q8TF08
boundary condition: true
name: COX7B2
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:170712
has only substance units: false

metaM retn c
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: all-trans-retinoate
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:35291

metaR DNDPt11m
modifier: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
product: MODEL1310110018#
name: dADP transport via dGDP antiport
reversible: false

metaM HC02206 c
name: prostaglandin C1(1-)
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57399

metaM m5mpdol U r
constant: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
is: SBO:0000247
is: CHEBI:37634

http://identifiers.org/biomodels.db/MODEL1310110018#_5917dd3e_32c0_4773_91d7_6ac95b8eaa7f
is: E9KL44
is encoded by: hsa:3030
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: HADHA

http://identifiers.org/biomodels.db/MODEL1310110018#_6c9bb253_ebe0_42b7_ab8e_38d74153720f
is: O95954
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: FTCD
type: Species
constant: false
is encoded by: hsa:10841
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_e88becb4_72c6_4607_b15f_aa6d098aab88
initial amount: NaN
has only substance units: false
name: UCK1
is: Q5JT09
is encoded by: hsa:83549
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR PIt8
reactant: MODEL1310110018#
name: phosphate transport in/out via Na+ symporter
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is: SBO:0000185
reversible: true
modifier: MODEL1310110018#

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR RPEc
type: Reaction
is described by: ECO:0000134
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c6361195_172f_43e7_a618_254a9ca781b9
has only substance units: false
name: SLC17A4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10050
is: Q9Y2C5
constant: false

metaR IDOAASE1ly
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110018#
fast: false
type: Reaction
modifier: MODEL1310110018#

metaR r2123
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110018#

metaR ACACT1x
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
modifier: MODEL1310110018#

metaM retn r
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
constant: false
is: CHEBI:35291
initial amount: NaN
is: HMDB01852
is: SBO:0000247
name: all-trans-retinoate
type: Species
boundary condition: false

metaR PGLYCt
product: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
type: Reaction
name: phosphatidylglycerol transport
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8a0c0391_43ea_4ac2_9c3a_7ddb908062b7
name: _AA977580_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AA977580

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: reverse-triiodthyronine
is: CHEBI:28774
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_539e2eea_c569_4dd8_822d_d1398ed903bd
is: Q92536
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:9057
is: SBO:0000252
name: SLC7A6
constant: false

metaM cyan c
name: hydrogen cyanide
is: HMDB02084
boundary condition: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM CE1944 c
is: CHEBI:36781
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: 1-pyrrolinium
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
has only substance units: false
is: SBO:0000247

metaM 5mthf e
is: HMDB01396
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:3729
type: Species
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
boundary condition: false
is: C00440
name: 5-Methyltetrahydrofolate

metaR GGT6
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_424afaa5_cb9d_4ff7_a598_3b4110ea0d55
boundary condition: true
type: Species
name: BCKDHA
is: B4DP47
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9d438d0b_f798_4045_a756_0464293bf3ce
initial amount: NaN
constant: false
is: SBO:0000252
is: P48448
has only substance units: false
name: ALDH3B2
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:222

metaR r2124
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
reversible: true
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_69a89dbd_d41c_4081_9ba3_1dd7f1d5d4cf
name: ACAT2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:39
is: Q9BWD1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f4a345ad_346d_401e_bb8f_c2017e80d6c8
is encoded by: hsa:1340
initial concentration: NaN
boundary condition: true
type: Species
is: P14854
constant: false
has only substance units: false
name: COX6B1
is: SBO:0000252
initial amount: NaN

metaR r0714
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_1813605c_0fbb_468f_aab4_c65ecae01e24
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4709
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: NDUFB3
is: Q6IB80

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR DESAT24 1
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
is described by: ECO:0000269
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_aed030ba_9c77_48c1_8c6c_178c71c87239
is encoded by: hsa:1339
has part: Q96KJ9
initial amount: NaN
has part: P14854
has part: Q53YB7
is encoded by: hsa:1340
is encoded by: hsa:125965
has part: P13073
boundary condition: true
is encoded by: hsa:170712
is encoded by: hsa:1347
has part: H0UI06
has part: P12074
has part: Q02221
constant: false
initial concentration: NaN
is encoded by: hsa:1345
has part: P09669
has part: Q7GXZ8
is encoded by: hsa:1329
is encoded by: hsa:4513
is encoded by: hsa:4512
is encoded by: hsa:84701
is encoded by: hsa:9167
is encoded by: hsa:1349
has only substance units: false
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1350
is: SBO:0000297
is encoded by: hsa:1346
has part: Q6YFQ2
is encoded by: hsa:1337
type: Species
is encoded by: hsa:9377
has part: Q8TF08
is encoded by: hsa:4514
has part: Q6FGA0
has part: P00414
has part: Q7Z4L0
has part: P20674
has part: Q7GXY8
has part: Q53XN1
is encoded by: hsa:1351
has part: P24311
is encoded by: hsa:341947
has part: P15954
is encoded by: hsa:1327
has part: P24310

metaR r0962
fast: false
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: false
type: Reaction

metaM glcur c
initial amount: NaN
constant: false
is: CHEBI:15748
is: SBO:0000247
name: D-glucuronate
is: HMDB00127
type: Species
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_45a38ef7_2ca8_4ec6_8e24_08f926c3ee47
initial amount: NaN
is: Q9H310
type: Species
boundary condition: true
is encoded by: hsa:57127
initial concentration: NaN
has only substance units: false
name: RHBG
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_cf258f53_b56e_420f_b35a_d003d62a8738
type: Species
is: P14618
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5315
is: SBO:0000252
has only substance units: false
name: PKM2
boundary condition: true

metaM xolest2 hs e
name: cholesterol ester
constant: false
type: Species
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:17002
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
initial concentration: 1.0
is: SBO:0000247
is: HMDB02917
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:17151
initial amount: NaN
type: Species

metaM phaccoa c
constant: false
has only substance units: false
name: phenylacetyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
type: Species
is: HMDB06503
boundary condition: false
is: CHEBI:57390
is: SBO:0000247

metaM coa x
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
is: SBO:0000247
is: HMDB01423
name: Coenzyme A
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57287
boundary condition: false
is: C00010

metaR r2121
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000185

metaR AG13T17g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110018#
reversible: false

metaR NACHEX9ly
modifier: MODEL1310110018#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110018#
type: Reaction
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal

metaM HC02187 e
is: SBO:0000247
boundary condition: false
name: reverse-triiodthyronine
constant: false
initial concentration: 1.0
is: CHEBI:28774
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
initial amount: NaN

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
product: MODEL1310110018#
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.4
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176

metaR RE3242R
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: RE3242
reversible: true

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_45a718f2_d9cf_4568_995b_e39a72413768
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: E2QC23
boundary condition: true
is encoded by: hsa:23464
name: GCAT
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c70de380_394d_47bc_8165_46c9cdc0291d
is: P22392
is encoded by: hsa:4831
type: Species
is: SBO:0000252
has only substance units: false
name: NME2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM 5mthf c
is: HMDB01396
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:3729
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
name: 5-Methyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
is: C00440

metaR r2122
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110018#
fast: false

metaM cyan e
constant: false
initial concentration: 1.0
is: CHEBI:18407
name: hydrogen cyanide
has only substance units: false
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
type: Species
is: HMDB02084
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_dd6f96a0_854c_4222_8caa_a00822e318ce
type: Species
initial concentration: NaN
name: ESD
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: P10768
is encoded by: hsa:2098
has only substance units: false

metaR r0960
reversible: true
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction

metaR PYDXtr
name: Pyridoxal transport
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
type: Reaction
product: MODEL1310110018#
reversible: true

metaR RDH1a
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.105
kinetic law: MODEL1310110018#
fast: false
reversible: true
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)
is: SBO:0000176

metaM but c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
name: butyrate
is: CHEBI:17968
type: Species
boundary condition: false
constant: false
is: HMDB00039

metaR r0716
type: Reaction
product: MODEL1310110018#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR MMSAD1m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
product: MODEL1310110018#
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM xylt c
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
is: SBO:0000247
type: Species
is: HMDB02917
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17151
initial concentration: 1.0

metaR UAG4E
kinetic law: MODEL1310110018#
is described by: ECO:0000304
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD

metaM sarcs c
is: CHEBI:3513
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: C00213
notes: FORMULA: C3H7NO2 CHARGE: 0
is: HMDB00271
initial concentration: 1.0
name: Sarcosine

metaR r0715
is described by: ECO:0000000
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
product: MODEL1310110018#
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110018#

metaR GALSIDEtl
reactant: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
product: MODEL1310110018#
name: galactocerebroside intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110018#

metaR FAOXC204C184m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR r2120
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
product: MODEL1310110018#

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR ENGASE3ly
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM dece4coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
name: 4-decenoylcoa
is: HMDB02145
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR ADK3m
name: adentylate kinase (GTP)
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.10

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR GTHPm
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15
is described by: ECO:0000269
is: SBO:0000176
name: glutathione peroxidase, mitochondria
type: Reaction
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c9119468_03d1_4d93_8109_862c048a7c78
constant: false
name: CYP7A1
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1581
is: SBO:0000252
type: Species
is: P22680

metaR RE3628M
product: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110018#
name: RE3628
reversible: true

metaR G14T5g
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110018#

metaR r0718
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
reversible: false
is: SBO:0000176
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_de5283fe_723f_4cbe_a5d2_d9b2f98a323d
type: Species
is: Q542Y6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:81579
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: PLA2G12A

metaR O2tp
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR GPIMTer U
reversible: false
is: SBO:0000176
fast: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#

metaM pac c
type: Species
is: SBO:0000247
is: HMDB00209
has only substance units: false
initial concentration: 1.0
is: CHEBI:18401
boundary condition: false
name: phenylacetate
initial amount: NaN
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_27accb47_ff1e_429b_96d0_94fd4245a128
is encoded by: hsa:NM 013421
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: _NM_013421_1_m
has only substance units: false
constant: false

metaR NDP7g
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176

metaR r0813
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
fast: false
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reactant: MODEL1310110018#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR VALtec
reversible: true
type: Reaction
is: SBO:0000185
name: L-valine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false

metaR r0812
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:

metaR MM7B2g
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
product: MODEL1310110018#
reversible: false
type: Reaction
modifier: MODEL1310110018#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_75fd3a8f_ded5_42a5_8485_386e71c4e7e8
has only substance units: false
is: Q9UJM8
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: HAO1
is encoded by: hsa:54363

metaR r0717
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
product: MODEL1310110018#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110018#

metaR LEUKTRD4t
product: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
name: leukotriene D4 transport
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_2258ad88_08e5_4347_9761_f230cea2ffec
is: SBO:0000252
is: P08236
type: Species
initial concentration: NaN
constant: false
name: GUSB
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2990

http://identifiers.org/biomodels.db/MODEL1310110018#_d25790b0_744e_41e7_bed9_9ea4d0f57429
is: SBO:0000252
initial concentration: NaN
name: NEU1
type: Species
constant: false
is: Q99519
boundary condition: true
is encoded by: hsa:4758
has only substance units: false
initial amount: NaN

metaM HC01162 c
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
constant: false
is: CHEBI:58376

metaR NDPK4n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_00a5a99a_4985_40db_980d_9aa6c5d5b55d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5743
has only substance units: false
initial amount: NaN
name: PTGS2
is: P35354
constant: false
type: Species

metaR SUBERCACT
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM acgpail hs c
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
constant: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57265
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR ALATHRNaEx
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110018#
type: Reaction

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR FAOXC141C121x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR PCHOL HSter
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: phosphatidylcholine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_188f5e6d_c3a6_434b_a927_7ed298bba41c
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: Q53HE2
has only substance units: false
type: Species
is encoded by: hsa:7167
name: TPI1

http://identifiers.org/biomodels.db/MODEL1310110018#_3d8c59aa_a0d6_411b_82a8_72eb318ad42a
is: Q9NY65
is encoded by: hsa:1962
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: EHHADH
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR FAOXC227C226m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM ksii core2 deg7 l
has only substance units: false
is: CHEBI:16953
initial amount: NaN
is: HMDB00812
notes: FORMULA: C44H73N4O30X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 7
boundary condition: false
type: Species
constant: false

metaR r0819
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000

metaR SCPx
is described by: ECO:0000269
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is version of: http://identifiers.org/ec-code/2.3.1.176
name: peroxisomal thiolase 2
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#

metaM 3mgcoa m
has only substance units: false
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01057
is: CHEBI:57346
name: trans-3-methylglutaconyl-CoA(5-)
constant: false
is: SBO:0000247
boundary condition: false

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
initial concentration: 1.0
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:18258

metaM sph1p e
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
is: HMDB01383
is: CHEBI:57939
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

metaR HSD17B42x
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction

metaM 2oxoadp c
initial concentration: 1.0
name: 2-oxoadipate(2-)
is: HMDB00225
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR G14T4g
product: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110018#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaM aflatoxin e
initial concentration: 1.0
constant: false
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:2504
initial amount: NaN
is: HMDB06552
boundary condition: false
name: aflatoxin B1

metaR GMPtn
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
name: GMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true

metaR MHISOR
reactant: MODEL1310110018#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
is: SBO:0000176
product: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.21
kinetic law: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110018#
is described by: ECO:0000269

metaM ksi pre4 g
name: keratan sulfate I biosynthesis, precursor 4
boundary condition: false
is: CHEBI:2504
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C101H165N7O72X CHARGE: -1
initial amount: NaN
constant: false
type: Species
is: HMDB06552

metaM hexde7coa x
has only substance units: false
constant: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 7-hexadecenoylcoa
boundary condition: false

metaR NACHEX11ly
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110018#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR RBFK
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.26
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: riboflavin kinase
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_136693cf_8821_4879_ae6e_d0810168c7cd
name: SYNJ1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8867
boundary condition: true
is: SBO:0000252
is: C9JFZ1
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_784c35db_ffe9_475c_bd42_19b5beac71d5
has only substance units: false
is encoded by: hsa:6515
constant: false
is: P11169
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC2A3

metaR RE3627M
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110018#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
name: RE3627
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

metaR NTD6
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: false
product: MODEL1310110018#
is described by: ECO:0000134
fast: false
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5

http://identifiers.org/biomodels.db/MODEL1310110018#_dee544dd_f4e5_4cbc_bf02_3caa276fef53
name: SLC14A1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6563
boundary condition: true
initial concentration: NaN
is: G0W2N5
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_d17a04f6_e40f_4bb5_a021_b3d7ea169893
type: Species
boundary condition: true
is encoded by: hsa:3614
constant: false
initial concentration: NaN
name: IMPDH1
initial amount: NaN
has only substance units: false
is: C9JV30
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_b789fcf5_d333_43a0_80f7_886546e9cd77
type: Species
initial concentration: NaN
name: PLCD3
is: Q8N3E9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:113026
has only substance units: false
boundary condition: true
constant: false

metaM ksi deg12 l
type: Species
has only substance units: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
name: keratan sulfate I, degradation product 12
boundary condition: false
is: SBO:0000247
is: HMDB00143
constant: false
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_a8cf2cef_f0ec_4f24_9b7c_d1d15721568f
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:6520
boundary condition: true
has part: P08195
initial amount: NaN
constant: false
has part: Q9NS82
has only substance units: false
type: Species
is encoded by: hsa:56301
name: SLC7A10:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110018#_31fe6514_2acf_455c_88a6_5c1441bfd19b
initial amount: NaN
has only substance units: false
is encoded by: hsa:3033
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q16836
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110018#_c02e2c6d_6c18_4d85_be9a_89773a004cf9
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: P22033
name: MUT
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4594

http://identifiers.org/biomodels.db/MODEL1310110018#_f8c62b03_bb93_493b_992c_4af87db9fea2
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9NY65
type: Species
name: EHHADH
is encoded by: hsa:1962
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_815ea947_8093_4fb7_ac2d_d17c8dc2f735
boundary condition: true
initial concentration: NaN
is encoded by: hsa:85365
initial amount: NaN
constant: false
is: Q9H553
has only substance units: false
name: ALG2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_516feab5_25dd_4939_b1a6_9cf5fbf52504
is: Q9BQL0
constant: false
name: BCKDHB
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:594
type: Species
has only substance units: false

metaM sph1p c
type: Species
has only substance units: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
initial concentration: 1.0
boundary condition: false
is: CHEBI:57939
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
constant: false
initial amount: NaN

metaR CYSTS
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.22
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
name: cystathionine beta-synthase
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD

metaM ksii core4 pre2 g
type: Species
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:2504
is: SBO:0000247
constant: false
name: keratan sulfate II boisynthesis, precursor 2
is: HMDB06552

metaM tdec4ecoa m
is: C08260
has only substance units: false
name: trans4decenoylcoa
boundary condition: false
is: HMDB00672
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR r0817
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
fast: false

metaM ddcacoa m
is: CHEBI:57375
is: HMDB03571
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
is: C01832
type: Species
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM 4mzym int1 r
is: SBO:0000247
constant: false
type: Species
is: HMDB06927
name: 4-Methylzymosterol intermediate 1
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR HMGCOAtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185

metaR UMPK3n
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110018#_1011daa4_e176_4739_95ff_b752e7beb145
is encoded by: hsa:10317
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: B3GALT5
has only substance units: false
type: Species
initial amount: NaN

metaM cyan m
type: Species
constant: false
name: hydrogen cyanide
is: CHEBI:18407
is: HMDB02084
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

metaR SALMCOM2
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: S-Adenosyl-L-methionine:catechol O-methyltransferase
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (118881.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.6 Confidence Level: 2 AUTHORS: PMID:7897657 NOTES:copied SAB's original NJ
product: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
fast: false
type: Reaction

metaR PDHm
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.4.1
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000134
fast: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.12
reactant: MODEL1310110018#
reversible: false
name: pyruvate dehydrogenase

metaR TDPm
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
name: thiamin pyrophosphatase, mitochondrial
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
reactant: MODEL1310110018#

metaM but e
initial concentration: 1.0
is: HMDB00039
constant: false
is: CHEBI:17968
boundary condition: false
name: butyrate
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

http://identifiers.org/biomodels.db/MODEL1310110018#_8176d050_9d9c_4086_869f_652baa87761c
is: P17050
is: SBO:0000252
is encoded by: hsa:4668
type: Species
name: NAGA
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR RE0456M
is described by: ECO:0000000
name: RE0456
type: Reaction
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
reversible: true

metaR RE3270C
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
type: Reaction
fast: false
name: RE3270
is: SBO:0000176
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_565833c0_e269_4821_9f59_e47ae78272b0
name: SLC33A1
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9197
boundary condition: true
type: Species
has only substance units: false
is: O00400

http://identifiers.org/biomodels.db/MODEL1310110018#_fe071869_a9c9_438e_8b39_9aae04d6828f
type: Species
is: SBO:0000252
name: PRDX2
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7001
is: P32119
constant: false

metaR GALASE3ly
reactant: MODEL1310110018#
reversible: false
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r2128
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110018#
type: Reaction
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_28e13f21_eaea_4d7b_b9ec_b95682c608d9
boundary condition: true
is: SBO:0000252
is: P55084
name: HADHB
initial amount: NaN
is encoded by: hsa:3032
initial concentration: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ac575ce5_8364_4ed0_b1d7_567d63d390c9
initial amount: NaN
is: SBO:0000252
name: MYO5B
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9H6Y6
is encoded by: hsa:4645
constant: false
type: Species

metaM glac r
type: Species
is: HMDB06355
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18268
name: D-glucurono-6,3-lactone
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1

metaR OCOAT1m
fast: false
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is: SBO:0000176
reactant: MODEL1310110018#
name: 3-oxoacid CoA-transferase
is version of: http://identifiers.org/ec-code/2.8.3.5
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#

W3 CDTF: Thu Aug 30 21:25:31 BST 2012

metaM CE2422 m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
constant: false
is: SBO:0000247
has only substance units: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
type: Species
is: CHEBI:28387
is: HMDB11123

metaM pydx5p e
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01491
is: SBO:0000247
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
name: pyridoxal 5'-phosphate(2-)
has only substance units: false
is: CHEBI:597326
initial concentration: 1.0
constant: false

metaM dpcoa m
type: Species
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01373
is: CHEBI:57328

metaR THP2Ctp
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ac6c9291_3e2b_46f4_b98e_3018640636c1
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6487
initial concentration: NaN
name: ST3GAL3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_1147ff3f_0458_46f5_830e_6b510766c02a
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5277
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000297
has part: P37287
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaM tsul e
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:16094
name: thiosulfate(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
is: HMDB00257

http://identifiers.org/biomodels.db/MODEL1310110018#_7e43b6ee_224f_4537_aed2_c3744da552d2
initial amount: NaN
name: PANK2
is encoded by: hsa:80025
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR AG13T18g
modifier: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_ebc40e63_862f_4d5d_b569_fcbd4f5dbe16
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM 2mop m
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
has only substance units: false
is: CHEBI:57700
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01172
initial amount: NaN

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51

metaR r2127
fast: false
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

W3 CDTF: Thu Aug 30 21:25:31 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110018#_bf9add1f_68be_40da_84ab_76dcc6f43339
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O14521
name: SDHD
initial concentration: NaN
is encoded by: hsa:6392
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a334740d_ad83_4785_9f24_66f3bd54dcc3
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56954
initial amount: NaN
is: SBO:0000252
name: NIT2
has only substance units: false
is: Q9NQR4
constant: false

metaR DHCRD2
reactant: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
name: dihydroceramide desaturase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
kinetic law: MODEL1310110018#
is described by: ECO:0000269
fast: false

metaM amp c
has only substance units: false
name: AMP
is: CHEBI:3322
initial amount: NaN
is: C00020
is: HMDB00045
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
type: Species
initial concentration: 1.0

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110018#

metaM 4fumacac c
is: HMDB01268
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:18034
constant: false
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
boundary condition: false

metaM xoldiolone c
has only substance units: false
is: SBO:0000247
is: CHEBI:28477
type: Species
is: HMDB02197
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f3ee82a7_2615_4004_beb1_c0be03b62e9f
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10870
boundary condition: true
is: SBO:0000252
is: Q9UBK5
name: HCST
type: Species
initial concentration: NaN

metaR r2126
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a54ecae0_3f15_442b_ad1f_62cbec32b115
name: _AA664770_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA664770
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM gal1p c
is: SBO:0000247
constant: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: HMDB00645
boundary condition: false
has only substance units: false
is: CHEBI:58336
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
initial amount: NaN
initial concentration: 1.0

metaM lnlncgcoa m
initial concentration: 1.0
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
type: Species
has only substance units: false

metaM pydx5p c
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00018
name: Pyridoxal 5'-phosphate
type: Species
constant: false
initial concentration: 1.0
is: HMDB01491
is: CHEBI:597326

http://identifiers.org/biomodels.db/MODEL1310110018#_5a5435c7_7c73_46c4_9862_c56a5b3f19f9
constant: false
boundary condition: true
has only substance units: false
is: E9PB82
is encoded by: hsa:3295
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: HSD17B4

metaM tsul c
initial amount: NaN
is: HMDB00257
has only substance units: false
name: thiosulfate(2-)
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16094
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

http://identifiers.org/biomodels.db/MODEL1310110018#_e618e7f2_8f0d_4bb1_ab72_9097e67a151d
constant: false
is: E9KL42
boundary condition: true
type: Species
is encoded by: hsa:641371
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACOT1

http://identifiers.org/biomodels.db/MODEL1310110018#_d9742eec_b986_4d11_b7a9_2f2557a0b826
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PDE6A
is: P16499
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5145

metaR S6T12g
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR GLYCTO1p
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: Glycolate oxidase, peroxisome
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD

metaR r2125
modifier: MODEL1310110018#
fast: false
reversible: true
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM triodthy e
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
constant: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:18258
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_57425a97_ae2c_41a0_8c5c_c49370aae2b0
name: SUCLG2
is encoded by: hsa:8801
type: Species
is: Q96I99
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR 3AIBtm
fast: false
product: MODEL1310110018#
reversible: false
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: 3-amino-isobutyrate transport, mitochondrial
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

W3 CDTF: Thu Aug 30 21:25:31 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110018#_a9697d08_0e7c_4999_a034_841b4565f6cb
has only substance units: false
name: FOLR1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:2348
initial concentration: NaN
type: Species
is: SBO:0000252
is: P15328

metaR BILGLCURtr
is described by: ECO:0000000
type: Reaction
reversible: true
name: glucuronidated compound transport
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

metaM ksi deg5 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
boundary condition: false
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: CHEBI:12936
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 5

http://identifiers.org/biomodels.db/MODEL1310110018#_9d619788_55fa_4bd2_84ad_3e1eb10a7f1b
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1644
name: DDC
boundary condition: true
is: Q53Y41
initial concentration: NaN
constant: false

metaM 3odcoa m
is: SBO:0000247
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
type: Species
initial concentration: 1.0
name: 3-Oxodecanoyl-CoA
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28528
is: HMDB03939
constant: false

metaM lnlncgcoa c
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57363
is: HMDB06368
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_e97b0de0_d851_4c24_9372_ce6635a7e27e
is encoded by: hsa:1629
is: SBO:0000297
type: Species
name: DBT:DLD:BCKDHA:BCKDHB
initial concentration: NaN
has part: P21953
is encoded by: hsa:594
boundary condition: true
has part: P11182
is encoded by: hsa:593
has only substance units: false
constant: false
has part: B4DP47
initial amount: NaN

metaM HC02206 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57399
initial amount: NaN
has only substance units: false
type: Species
name: prostaglandin C1(1-)
boundary condition: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM g2m8masn r
boundary condition: false
has only substance units: false
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05874
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C82H137N2O65X CHARGE: 0

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM HC01401 x
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
type: Species
constant: false
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_6ec8f777_16c8_4171_b48b_775af72ec796
is encoded by: hsa:223
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P49189
type: Species
name: ALDH9A1
boundary condition: true
initial concentration: NaN

metaM hs deg15 l
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate, degradation product 15
constant: false
is: CHEBI:16126
boundary condition: false
has only substance units: false

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: HMDB03571
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57375

http://identifiers.org/biomodels.db/MODEL1310110018#_08dad6f7_2c99_4d29_9bfd_74ae35032b33
initial concentration: NaN
is: SBO:0000252
is: A0PJK1
boundary condition: true
is encoded by: hsa:125206
name: SLC5A10
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_61210132_d4b9_4b54_a123_14bad527f9d8
boundary condition: true
is: Q9UJA2
is: SBO:0000252
constant: false
has only substance units: false
name: CRLS1
initial amount: NaN
type: Species
is encoded by: hsa:54675
initial concentration: NaN

metaM xu5p D c
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial amount: NaN
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
is: CHEBI:57737
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3e478f9c_8a72_4d55_b119_7a3368fd8a2a
name: PDE9A
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c02d4f97_4c35_44d3_9c72_14e4fbb0dfc4
constant: false
has only substance units: false
boundary condition: true
name: CHKB
is: Q9Y259
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1120
type: Species

metaR FAOXTC102C101m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e6fa17e8_1236_4565_9934_8ba78bf17c16
name: MAN1A2
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10905
constant: false
has only substance units: false
is: O60476
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_e76c97d6_236d_47f6_8dc8_131590a75fc2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152

metaR EX CE1939 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine monoaldehyde 1 exchange
type: Reaction

metaR ITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
name: ITP nuclear transport
reversible: true
is: SBO:0000185

metaM glac c
name: D-glucurono-6,3-lactone
is: SBO:0000247
is: HMDB06355
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
boundary condition: false
is: CHEBI:18268
type: Species
initial concentration: 1.0

metaR SUCD1m
is described by: ECO:0000134
name: succinate dehydrogenase
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaM guln r
boundary condition: false
is: SBO:0000247
is: HMDB03290
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:13115
constant: false
name: L-gulonate
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaM vacc e
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: SBO:0000247
initial concentration: 1.0
name: trans-vaccenate
has only substance units: false
is: CHEBI:30828
boundary condition: false

metaM cpppg3 c
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
constant: false
is: CHEBI:57309
boundary condition: false
initial concentration: 1.0
is: HMDB01261
name: Coproporphyrinogen III
type: Species
is: SBO:0000247
is: C03263
has only substance units: false
initial amount: NaN

W3 CDTF: Thu Aug 30 21:25:31 BST 2012

metaR UAG2EMAi
is described by: ECO:0000269
reversible: false
product: MODEL1310110018#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
fast: false
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_deb41fca_0cc5_4433_b49b_5586db80a3de
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:249
initial concentration: NaN
boundary condition: true
is: B7Z4Y6
has only substance units: false
name: ALPL
initial amount: NaN

metaM mi14p c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58282
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
initial amount: NaN

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR r1487
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110018#
reversible: true
name: EC:6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_4acaba18_2bde_4a27_a230_62da5480d683
type: Species
has only substance units: false
name: PDE4B
constant: false
boundary condition: true
is encoded by: hsa:5142
initial concentration: NaN
is: Q5TEK5
is: SBO:0000252
initial amount: NaN

metaM dolmanp U c
name: Dolichyl phosphate D-mannose, human uterine homolog
is: CHEBI:15809
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_304b8dbf_aa64_4acd_b2cc_919b235bc1d8
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1806
initial amount: NaN
initial concentration: NaN
type: Species
is: Q12882
name: DPYD

http://identifiers.org/biomodels.db/MODEL1310110018#_8ed18361_6907_4d19_b999_8c80b1d4e60b
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: HMGCS1
initial amount: NaN
is encoded by: hsa:3157

http://identifiers.org/biomodels.db/MODEL1310110018#_06db2c95_b0fd_4544_95b7_b85b5e420911
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9BQG2
is encoded by: hsa:83594
name: NUDT12

metaR biomass reaction
is: SBO:0000185
name: Generic human biomass reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_365898af_7654_42c3_bf1c_913b1d71c6be
is: P49448
name: GLUD2
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2747
type: Species
initial concentration: NaN
boundary condition: true

metaR BAAT2x
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000269

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR ACONTm
fast: false
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
kinetic law: MODEL1310110018#
is: SBO:0000176

metaM vacc c
is: C08367
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
type: Species
boundary condition: false
is: CHEBI:30828
name: trans-vaccenate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_433fe545_1d04_4918_9808_b435d5c09c97
name: PIGM
is encoded by: hsa:93183
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: Q9H3S5
boundary condition: true
is: SBO:0000252

metaM dcmp n
is: SBO:0000247
has only substance units: false
is: CHEBI:57566
type: Species
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
constant: false
name: dCMP(2-)
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_96e161df_477d_4ead_831b_ac3f91af8d8a
is: SBO:0000252
constant: false
initial concentration: NaN
name: DGAT1
is encoded by: hsa:8694
initial amount: NaN
is: O75907
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_c37f6817_1856_4edb_af68_c0d4823c8f5d
is: O43868
type: Species
name: SLC28A2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9153
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR ACHEe
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
reversible: false
name: Acetylcholinesterase
fast: false
is described by: ECO:0000269
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.1.7

metaM cholcoa c
has only substance units: false
is: CHEBI:57373
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01374
boundary condition: false
name: choloyl-CoA(4-)
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN

metaM tsul m
has only substance units: false
is: SBO:0000247
is: HMDB00257
name: thiosulfate(2-)
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
type: Species

metaM 4mlacac c
is: CHEBI:17105
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
initial concentration: 1.0
name: 4-maleylacetoacetate

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR GLYOX
is version of: http://identifiers.org/ec-code/3.1.2.6
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
name: hydroxyacylglutathione hydrolase

metaR SPH1Pte
type: Reaction
reactant: MODEL1310110018#
fast: false
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110018#

metaM dha e
constant: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
has only substance units: false
is: CHEBI:16016
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: glycerone
is: HMDB01882

http://identifiers.org/biomodels.db/MODEL1310110018#_79c95b88_e18a_420e_9b54_d3b769eec908
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: B3GNTL1
is encoded by: hsa:146712
constant: false
is: Q67FW5

http://identifiers.org/biomodels.db/MODEL1310110018#_81c2154b_5a54_4246_ae69_757b6dee9bfc
is: F8VQS7
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFA12
has only substance units: false
type: Species
is encoded by: hsa:55967

metaR AG13T7g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110018#
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false

metaM nrvnccoa x
initial amount: NaN
is: C16532
has only substance units: false
constant: false
name: nervonyl coenzyme A
boundary condition: false
type: Species
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
is: SBO:0000247
initial concentration: 1.0

metaM dpcoa c
is: C00882
initial concentration: 1.0
is: CHEBI:57328
has only substance units: false
boundary condition: false
name: Dephospho-CoA
constant: false
is: SBO:0000247
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
type: Species

metaM fdp c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16905
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: C00354
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
is: http://identifiers.org/pubchem.compound/3647

metaR FAOXC102m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_23b8a43f_517e_4a0f_a695_4bae05d7f109
is: P51570
name: GALK1
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:2584
initial concentration: NaN
type: Species

metaM estradiol c
is: SBO:0000247
name: estradiol
type: Species
is: CHEBI:16469
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151
boundary condition: false
has only substance units: false

metaM cyst L c
is: SBO:0000247
is: HMDB00099
initial concentration: 1.0
boundary condition: false
name: L-cystathionine
type: Species
is: CHEBI:17482
initial amount: NaN
constant: false
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
has only substance units: false

metaR 13DAMPPOX
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
fast: false
reversible: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is described by: ECO:0000212

metaR RNMK
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.22
fast: false
name: ribosylnicotinamide kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
product: MODEL1310110018#
type: Reaction

metaR FUMSO4tm
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
is: SBO:0000185
name: Fumarate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110018#

metaR HEXDIACTD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2da168ad_8790_454e_8604_c9e5f516163c
has only substance units: false
initial amount: NaN
is: P61457
is encoded by: hsa:5092
initial concentration: NaN
type: Species
name: PCBD1
constant: false
is: SBO:0000252
boundary condition: true

metaR TAURtcx
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
kinetic law: MODEL1310110018#
name: taurine transport (sodium symport) (cytosol to peroxisome)
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000212
product: MODEL1310110018#

metaR GULNDer
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
name: gulonate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110018#
reversible: true
fast: false

metaM orot5p c
initial amount: NaN
type: Species
is: HMDB00218
name: Orotidine 5'-phosphate
boundary condition: false
constant: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C01103
is: CHEBI:57538

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM hLkynr c
is: HMDB11631
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 3-hydroxy-L-kynurenine
has only substance units: false
is: CHEBI:17380
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a8c8cd23_fca6_421e_a06d_6a8ac2543cd1
constant: false
is: SBO:0000252
is encoded by: hsa:4728
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: NDUFS8
initial concentration: NaN
is: O00217

metaM 2mop c
is: SBO:0000247
is: CHEBI:57700
has only substance units: false
is: HMDB01172
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_12a67e9d_2be0_48d6_9168_b7617c297c88
is: A0PJJ9
type: Species
is encoded by: hsa:2686
name: GGT7
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR MDHm
kinetic law: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
fast: false
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
product: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
name: malate dehydrogenase, mitochondrial
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaM dpcoa e
is: C00882
is: CHEBI:57328
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
name: Dephospho-CoA
is: HMDB01373
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_a0a723c1_3f0b_458b_b776_fc781f76bb5e
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1609
is: P52824
initial concentration: NaN
type: Species
constant: false
name: DGKQ
initial amount: NaN
boundary condition: true

metaM dtdp n
constant: false
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58369
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110018#_a292d2dd_843a_4161_904d_07a2939c80f0
boundary condition: true
initial amount: NaN
is: O00217
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NDUFS8
type: Species
constant: false
is encoded by: hsa:4728

metaM arg L c
initial concentration: 1.0
boundary condition: false
is: CHEBI:32682
initial amount: NaN
is: HMDB00517
constant: false
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_8f759b18_68db_49b1_8723_1af945fc467f
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:H17063
has only substance units: false
name: _H17063_1_c
type: Species
initial concentration: NaN

metaM acgam1p c
has only substance units: false
initial amount: NaN
name: N-Acetyl-D-glucosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01367
is: CHEBI:7125
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_bc9aa4ac_0f1a_42f5_9d10_caf877326af4
initial amount: NaN
is encoded by: hsa:56623
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9NRR6
constant: false
boundary condition: true
name: INPP5E
has only substance units: false

metaR GALASE18ly
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110018#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR DMNONCOACRNCPT1
reactant: MODEL1310110018#
type: Reaction
reversible: true
name: DMNONCOACRNCPT1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
is: SBO:0000176

metaM 4hpro LT e
has only substance units: false
boundary condition: false
type: Species
constant: false
name: trans-4-hydroxy-L-proline
initial concentration: 1.0
initial amount: NaN
is: HMDB00725
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

metaM dtdp m
is: HMDB01274
initial amount: NaN
name: dTDP
is: SBO:0000247
boundary condition: false
type: Species
is: C00363
initial concentration: 1.0
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
has only substance units: false

metaM ump g
type: Species
is: SBO:0000247
name: UMP(2-)
constant: false
is: HMDB00288
is: CHEBI:57865
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110018#_0b93dd28_43e7_4937_89be_991a5572780f
type: Species
name: GALNT7
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:51809
is: Q86SF2
boundary condition: true
is: SBO:0000252
constant: false

metaM pmtcrn c
boundary condition: false
is: SBO:0000247
is: HMDB00222
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial concentration: 1.0
name: L-palmitoylcarnitine
has only substance units: false
initial amount: NaN
constant: false

metaR AASAD3m
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES:MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#

metaR R group phosphotase 1
is: SBO:0000176
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
name: R group phosphotase 1
type: Reaction

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:27809
name: L-4-hydroxyglutamic semialdehyde
boundary condition: false
is: HMDB06556
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_2aaf7a5d_623f_45bb_b777_50c3d6db378d
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:728637
name: _728637_1_c
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR G14T11g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a40f3f52_d219_4e3c_a251_2d25fdf06978
name: LDHC
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3948
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR r0531
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110018#_d62d285e_adb1_436a_a017_c39e7f301c23
type: Species
is encoded by: hsa:4707
is: SBO:0000252
initial amount: NaN
constant: false
name: NDUFB1
is: O75438
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR DIDPtn
type: Reaction
name: dIDP nuclear transport
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_ef9cc55b_e473_44dc_a656_69bad596278d
type: Species
is: Q6P1K9
boundary condition: true
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PANK2
initial concentration: NaN
constant: false

metaR SUCCt2m
name: succinate transport, mitochondrial
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3a8fb15b_32bd_4a28_a7e9_7de1deb3bd99
is: SBO:0000252
is: P25325
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4357
has only substance units: false
name: MPST

metaM arg L e
initial concentration: 1.0
name: L-argininium(1+)
is: SBO:0000247
has only substance units: false
is: HMDB00517
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
type: Species
initial amount: NaN

metaM ser L m
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:17115
is: HMDB00187
is: SBO:0000247

metaM kynate c
is: HMDB00715
name: kynurenate
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58454
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_30d66ff8_8d26_442e_9229_1e56756664c3
is: SBO:0000252
constant: false
type: Species
is: Q13615
boundary condition: true
initial amount: NaN
is encoded by: hsa:8897
initial concentration: NaN
name: MTMR3
has only substance units: false

metaR D LACt2
kinetic law: MODEL1310110018#
name: D-lactate transport via proton symport
modifier: MODEL1310110018#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaR r1492
reversible: false
reactant: MODEL1310110018#
name: Utilized transport
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM 4mptnl m
is: HMDB01318
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:17998
constant: false
has only substance units: false
type: Species
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
name: 4-methylpentanal
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_c7ef8b09_a9ea_4abe_af55_3a26d877073e
type: Species
name: QDPR
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5860
has only substance units: false
initial amount: NaN
constant: false
is: P09417

metaR AG13T3g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110018#
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110018#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b784dd9f_aaaf_4b88_97bc_55ed361395f5
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:AF080579
has only substance units: false
name: _AF080579_1_c
is: SBO:0000252

metaR r0744
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR MGCHrm
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
reactant: MODEL1310110018#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_1a622b1d_9af5_46bc_bcad_1c45843f27e0
is encoded by: hsa:5152
has only substance units: false
initial amount: NaN
name: PDE9A
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM lald D c
type: Species
boundary condition: false
is: CHEBI:17167
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06458
constant: false

metaR O2St
fast: false
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
name: superoxide anion transport via diffusion (extracellular)

metaR LEUTAm
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial
modifier: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176

metaR FAOXC12C10x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaM malthp e
boundary condition: false
type: Species
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: C01936
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: maltoheptaose

metaR GBA
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.45
product: MODEL1310110018#
modifier: MODEL1310110018#
name: Glucosylceramidase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_8a269826_e8ab_49fc_aa17_26972a4d525b
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: Q9UFY1
initial concentration: NaN
name: PLCG1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5335

metaM succ x
has only substance units: false
constant: false
is: HMDB00254
boundary condition: false
is: SBO:0000247
is: C00042
name: Succinate
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
initial concentration: 1.0
is: CHEBI:30031

http://identifiers.org/biomodels.db/MODEL1310110018#_6dd03b38_1f44_46e8_b16a_9f918d1d5cab
has part: C9JT23
is encoded by: hsa:4540
boundary condition: true
has part: Q6IBC4
has part: P03915
has part: P56181
has part: Q16795
has part: P56556
is encoded by: hsa:4535
is encoded by: hsa:4702
is encoded by: hsa:4697
is encoded by: hsa:4722
has part: O75489
has part: O43678
initial amount: NaN
has part: B7Z792
is encoded by: hsa:4714
has part: O43181
is encoded by: hsa:4707
has part: O43677
is encoded by: hsa:7991
is encoded by: hsa:4694
is encoded by: hsa:4719
is encoded by: hsa:4715
is encoded by: hsa:4711
is encoded by: hsa:4731
has part: P03905
is encoded by: hsa:4698
has part: O95139
is encoded by: hsa:4539
is encoded by: hsa:4726
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q13454
has part: P28331
has part: P19404
is encoded by: hsa:4536
has part: O95299
is encoded by: hsa:4723
has part: O14561
has part: O95169
is: SBO:0000297
is encoded by: hsa:4708
has part: Q549M5
is encoded by: hsa:4728
has part: O00483
has part: O00217
has part: F8VQS7
is encoded by: hsa:4704
is encoded by: hsa:4720
is encoded by: hsa:4700
is encoded by: hsa:4695
is encoded by: hsa:126328
has part: Q9Y6M9
has part: O43674
has part: O75438
is encoded by: hsa:4716
type: Species
has part: O75251
is encoded by: hsa:4712
has part: Q6FG42
has part: H7C5B8
is encoded by: hsa:4717
is encoded by: hsa:374291
has only substance units: false
has part: A8K761
has part: Q6IBB5
has part: Q7GXZ1
has part: Q6IB80
is encoded by: hsa:51079
has part: P03897
is encoded by: hsa:4541
is encoded by: hsa:4537
is encoded by: hsa:4724
constant: false
is encoded by: hsa:4709
has part: B1AM93
is encoded by: hsa:4729
has part: Q85KV6
is encoded by: hsa:4705
has part: O95168

metaR BILIRUBtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
product: MODEL1310110018#
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaR r0743
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_0adecb34_beaf_467c_9e92_f055b5c660fd
constant: false
has part: Q92569
type: Species
has part: A7E2E0
boundary condition: true
is encoded by: hsa:5293
initial concentration: NaN
is encoded by: hsa:8503
initial amount: NaN
name: PIK3CD:PIK3R3
is: SBO:0000297
has only substance units: false

metaM thcholstoic m
is: SBO:0000247
is: HMDB03873
boundary condition: false
is: CHEBI:18402
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN

metaM glyb e
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
is: HMDB00043
name: glycine betaine
is: CHEBI:17750
boundary condition: false
type: Species
initial concentration: 1.0

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM xoldioloneh c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:2288
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: HMDB06887
boundary condition: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species

metaR RE0828E
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
name: RE0828
fast: false

metaR LPS3e
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.3
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
name: lipase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110018#_ed4593e3_11bc_46a4_b5cc_2f9437a3253e
name: PNMT
type: Species
boundary condition: true
initial concentration: NaN
is: P11086
initial amount: NaN
is encoded by: hsa:5409
is: SBO:0000252
constant: false
has only substance units: false

metaM dag hs r
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
initial amount: NaN
is: CHEBI:18035

metaR S6TASE10ly
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110018#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR RE1447M
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
fast: false
name: RE1447
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
product: MODEL1310110018#

metaR FUCASE2e
is described by: ECO:0000000
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
name: alpha-fucosidase, extracellular
modifier: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.51
fast: false
is: SBO:0000176

metaM ump c
constant: false
is: CHEBI:57865
initial concentration: 1.0
is: HMDB00288
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_189aa4a6_6e22_4f3d_8b45_05d3518f2a7a
name: GALT
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2592
initial amount: NaN
is: B2RAT6
boundary condition: true

metaR r0741
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
fast: false
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_2b3e7e00_e830_4d6c_93fe_9e135249908f
initial concentration: NaN
type: Species
is encoded by: hsa:100128062
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: _100128062_1_m

metaR 3DSPHR
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.102
product: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: 3-Dehydrosphinganine reductase

metaR r1167
reactant: MODEL1310110018#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
is described by: ECO:0000000
name: EC:2.3.1.26
product: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_e26aec02_1fef_43a7_8803_b10915e9f856
initial concentration: NaN
constant: false
is: Q08828
type: Species
is: SBO:0000252
has only substance units: false
name: ADCY1
boundary condition: true
initial amount: NaN
is encoded by: hsa:107

metaR NAIt
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
reversible: true
name: Na+ / iodide cotransport
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110018#
fast: false

metaR DHPM1
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.2.2
modifier: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
name: dihydropyrimidinase (5,6-dihydrouracil)

http://identifiers.org/biomodels.db/MODEL1310110018#_060515c4_68ea_4ca4_9676_bf933106cd33
initial amount: NaN
is: E9KL48
name: GLUD1
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:2746
boundary condition: true
initial concentration: NaN

metaR FACOAL241
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110018#

metaM glyb c
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
name: glycine betaine
initial amount: NaN
is: SBO:0000247
is: HMDB00043
boundary condition: false
is: CHEBI:17750
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_07e0f9e6_f678_4fcf_aadd_20c3ba6db196
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: Q96KJ9
name: COX4I2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84701
boundary condition: true

metaR SIAASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
name: sialidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM retinal c
is: CHEBI:15035
boundary condition: false
name: retinal
is: HMDB01358
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
initial amount: NaN
has only substance units: false

metaR RE1447N
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
name: RE1447
fast: false
reactant: MODEL1310110018#

metaM 4hpro LT c
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
type: Species
is: HMDB00725
is: SBO:0000247
initial amount: NaN

metaM 5dpmev c
is: HMDB01090
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial amount: NaN
has only substance units: false
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR FACOAL240
modifier: MODEL1310110018#
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM e4hglu m
is: HMDB02273
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false
is: CHEBI:6331
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0936
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: Transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_bd495e41_40d0_40b6_a162_3d1ca3d2c38e
name: GALNTL2
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:117248
is: Q8N3T1
initial concentration: NaN

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57795
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435

metaR XYLt
name: D-xylose reversible transport
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110018#
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaM ump e
is: SBO:0000247
is: HMDB00288
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
initial amount: NaN
name: UMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110018#_0207c950_a8d1_4e45_b8d9_dc41cbf3dda2
is: Q86VV3
is encoded by: hsa:953
is: SBO:0000252
name: ENTPD1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR H2Otp
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110018#
name: H2O transport, peroxisomal
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ccfff348_27d9_43b0_87cb_2db06a415874
name: SLC4A4
is: A5JJ20
type: Species
boundary condition: true
is encoded by: hsa:8671
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR MTHFR3
reversible: false
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.20
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
kinetic law: MODEL1310110018#
is described by: ECO:0000134
modifier: MODEL1310110018#

metaR ICDHy
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110018#
name: isocitrate dehydrogenase (NADP)
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269

metaR FTCD
product: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.2.5
name: formimidoyltransferase cyclodeaminase
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_78c88243_4991_40a0_97f1_3bb7dcd8c785
is encoded by: hsa:8706
is: SBO:0000252
is: O75752
initial amount: NaN
initial concentration: NaN
name: B3GALNT1
type: Species
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_2e01e01d_97a7_43e1_98a4_63b3c1d02880
is: Q6P1M0
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: SLC27A4
is encoded by: hsa:10999

metaM 4hoxpacd c
boundary condition: false
is: CHEBI:15621
initial amount: NaN
type: Species
is: HMDB03767
has only substance units: false
name: (4-hydroxyphenyl)acetaldehyde
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 4hpro LT m
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial concentration: 1.0
constant: false
initial amount: NaN
name: trans-4-hydroxy-L-proline
is: HMDB00725
is: CHEBI:18095
boundary condition: false

metaR SQLEr
is described by: ECO:0000134
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
product: MODEL1310110018#
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
name: Squalene epoxidase, endoplasmic reticular (NADP)
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.14.13.132

http://identifiers.org/biomodels.db/MODEL1310110018#_7210b237_9913_4e18_9c9a_adab7f41b64e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: FUT8
is encoded by: hsa:2530
initial amount: NaN
is: Q9BYC5
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_9af407f1_4772_44f7_95e2_1794b75cec24
constant: false
initial concentration: NaN
name: NDUFAB1
is: O14561
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:4706

metaM ump n
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
name: UMP(2-)
initial amount: NaN
is: HMDB00288

metaR r1019
fast: false
reactant: MODEL1310110018#
name: Postulated transport reaction
product: MODEL1310110018#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction

metaR CYTK7
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP)
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_7e6377c5_494e_4d90_b96c_9c2e1a541216
name: PANK4
is encoded by: hsa:55229
boundary condition: true
is: Q9NVE7
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR RE2659R
fast: false
name: RE2659
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110018#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaM ksi deg41 l
initial amount: NaN
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 41
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaR 1PPDCRp
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
name: delta1-piperideine-2-carboxylate reductase, perixosomal

metaM ser L c
boundary condition: false
initial concentration: 1.0
is: HMDB00187
has only substance units: false
name: L-serine
initial amount: NaN
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ddcc8600_b7ea_4c42_835e_01eba7aa2640
has only substance units: false
boundary condition: true
is encoded by: hsa:2678
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: GGT1
constant: false

metaM phytcoa x
has only substance units: false
is: HMDB01359
constant: false
name: phytanoyl-CoA(4-)
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_aabbddc8_cdaf_47f7_9fd1_eef6ea96990b
constant: false
type: Species
name: HADHA:HADHB
is encoded by: hsa:3032
has part: P55084
has part: E9KL44
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3030

metaM sbt D e
initial concentration: 1.0
is: HMDB00247
initial amount: NaN
name: D-glucitol
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
type: Species

metaM fad x
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
is: HMDB01248
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized

metaR CYSSNAT5tc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR DHCR71r
name: 7-dehydrocholesterol reductase
product: MODEL1310110018#
is described by: ECO:0000134
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
fast: false

metaR GGH 7DHFe
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
kinetic law: MODEL1310110018#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false

metaR r1018
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
name: Transport reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c3d55283_3e62_42d0_98e2_5dfa3fe9422d
is: SBO:0000252
is: P00374
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1719
constant: false
initial concentration: NaN
name: DHFR
has only substance units: false

metaR S3TASE1ly
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
type: Reaction
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_19aa8c3d_d31f_4096_847a_ee8359bf316e
boundary condition: true
name: GCH1
is encoded by: hsa:2643
is: Q8IZH9
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK6
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (CMP,CTP)
type: Reaction
reactant: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110018#

metaM 4h2oglt m
boundary condition: false
is: HMDB02070
initial concentration: 1.0
is: CHEBI:17742
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: 4-hydroxy-2-oxoglutarate(2-)
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2

http://identifiers.org/biomodels.db/MODEL1310110018#_009a0eeb_1bc3_49d0_90c7_b95d85177700
constant: false
type: Species
name: ACADVL
is: P49748
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:37
has only substance units: false
initial amount: NaN

metaM arg L m
is: HMDB00517
initial concentration: 1.0
has only substance units: false
name: L-argininium(1+)
is: CHEBI:32682
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
type: Species
is: SBO:0000247

metaM ksi deg6 l
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
name: keratan sulfate I, degradation product 6
is: CHEBI:12936
type: Species
boundary condition: false

metaR AG13T14g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110018#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM retinol e
name: retinol
has only substance units: false
is: HMDB00305
is: CHEBI:50211
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
boundary condition: false

metaM dtdp e
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
initial amount: NaN
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
type: Species

metaR CYTDK1
name: ATPcytidine 5-phosphotransferase
modifier: MODEL1310110018#
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_df9c29dd_7007_4ea0_b837_1dabfcba524e
is: SBO:0000252
name: _AI971036_1_x
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI971036
initial amount: NaN
boundary condition: true

metaR 4ABUTtcn
type: Reaction
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110018#
is described by: ECO:0000134
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
name: transport of GABA

http://identifiers.org/biomodels.db/MODEL1310110018#_af30dc93_fb2c_4257_8bc3_c916a2fde2e3
has only substance units: false
is: P07864
initial amount: NaN
initial concentration: NaN
name: LDHC
is encoded by: hsa:3948
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaM 3sala c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3-Sulfino-L-alanine
is: C00606
type: Species
is: CHEBI:61085

metaM air c
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01235
is: C03373
boundary condition: false
is: SBO:0000247
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
initial amount: NaN
type: Species

metaM 4mptnl e
name: 4-methylpentanal
is: HMDB01318
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17998
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373

http://identifiers.org/biomodels.db/MODEL1310110018#_94e28ef1_521c_4f83_9745_ae13424a0425
name: NMNAT2
is encoded by: hsa:23057
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaR PAPtg
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
name: adenosine 3',5'-bisphosphate Golgi transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000185

metaR MM8Ber
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_e8db30ea_9acc_4544_bacc_9ede453f2300
boundary condition: true
is encoded by: hsa:54187
has only substance units: false
initial amount: NaN
is: Q9NR45
name: NANS
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_84acc286_81ff_4871_99aa_50678bae439d
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI926493
name: _AI926493_1_m
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR RADH2
name: retinal dehydrogenase (NADPH)
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_82c9da87_38ba_48f4_a655_c29d70da42ee
name: COX6A1
boundary condition: true
is: P12074
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1337

metaM ser L e
is: HMDB00187
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: L-serine
is: CHEBI:17115
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_14702fdf_9d08_479f_950b_924454e5912b
is: SBO:0000252
constant: false
name: ADCY6
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:112
type: Species
initial concentration: NaN

metaM dtdp c
constant: false
is: HMDB01274
is: CHEBI:58369
is: C00363
initial amount: NaN
type: Species
name: dTDP
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR LCADi
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: lactaldehyde dehydrogenase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110018#

metaR CYTK8
fast: false
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: cytidylate kinase (CMP,dATP)
reversible: true
is described by: ECO:0000269

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM ppbng c
type: Species
is: C00931
boundary condition: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
name: Porphobilinogen
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58126
is: HMDB00245
initial concentration: 1.0
is: SBO:0000247

metaR CYTK9
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP)
modifier: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM core2 g
is: CHEBI:15876
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: Core 2

metaR ALAt4
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: false
is: SBO:0000185
name: Alanine-Sodium symporter
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
reactant: MODEL1310110018#
is described by: ECO:0000269

metaR CYTK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
fast: false
name: cytidylate kinase (CMP)(GTP)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110018#_b9358aba_17a7_4fc6_96b5_440c172af391
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: B4GALT2
is encoded by: hsa:8704
has only substance units: false
initial amount: NaN

metaM pydx e
initial concentration: 1.0
is: C00250
is: HMDB01545
is: CHEBI:17310
initial amount: NaN
constant: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
name: Pyridoxal
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_673e5873_f051_49ab_a140_865710a167b8
name: CHKB
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1120
initial concentration: NaN
is: SBO:0000252
is: A0PJM6

metaM fmn c
is: CHEBI:58210
type: Species
has only substance units: false
name: FMN
is: C00061
boundary condition: false
initial amount: NaN
is: HMDB01520
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_8b5699a9_4b57_4456_874e_09173f27b6a1
name: PIK3C3
constant: false
is: Q8NEB9
initial amount: NaN
type: Species
is encoded by: hsa:5289
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r0821
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction

metaR S6TASE11ly
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110018#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_39a9e769_c9e0_4a05_9a24_01fa52388dd8
constant: false
is: O95498
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: VNN2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8875

metaM 5mdr1p c
has only substance units: false
is: C04188
constant: false
initial concentration: 1.0
type: Species
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
is: CHEBI:58533
initial amount: NaN
is: HMDB00963
boundary condition: false
is: SBO:0000247

metaR DALAt2r
reactant: MODEL1310110018#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110018#
fast: false
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_0b93fd36_6a49_4b59_83a1_e0dcb80b1ff9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:218
name: ALDH3A1
constant: false
is: P30838
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM 4mptnl c
is: SBO:0000247
is: CHEBI:17998
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
constant: false
initial amount: NaN
type: Species
name: 4-methylpentanal
is: HMDB01318
initial concentration: 1.0

metaR FAOXC185m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR r2110
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR CYTK2
name: cytidylate kinase (dCMP)
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110018#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110018#

metaR DM fol
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR r0311
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction

metaM dhcrm hs c
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
name: dihydroceramide
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:31488
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_41d5687f_8d48_443e_881c_020f8730e245
constant: false
initial concentration: NaN
is encoded by: hsa:124935
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8N370
name: SLC43A2

metaR VALTAm
name: valine transaminase, mitochondiral
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_503bc78b_c2be_4750_8c82_eb20ca5415ff
is: SBO:0000252
is: F5H6D0
is encoded by: hsa:7841
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: MOGS
constant: false

metaR HMGCOASi
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
reversible: false

metaR AFLATOXINte
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110018#
name: xenobiotic transport
fast: false
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000

metaR GMPtg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)
fast: false
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a2e5a078_db23_46ce_b7c4_3f66ac29af8d
is: SBO:0000252
type: Species
is encoded by: hsa:6581
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q5SYN6
name: SLC22A3
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_1a9c0338_3b40_40a5_8e4d_421c8b8979dd
initial amount: NaN
type: Species
name: AOC3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q16853
is encoded by: hsa:8639

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaR CYTK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110018#
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110018#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110018#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_f3d713dd_de07_4e40_9403_2e792a285ba2
is: Q99643
name: SDHC
is encoded by: hsa:6391
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_d875dba8_a676_4822_aead_a3c1536376ba
constant: false
is encoded by: hsa:5140
is: Q13370
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: PDE3B
boundary condition: true

metaR r2111
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM fad r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16238
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaM pydx c
initial concentration: 1.0
is: SBO:0000247
is: C00250
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: HMDB01545
is: CHEBI:17310
initial amount: NaN
constant: false
name: Pyridoxal
has only substance units: false
type: Species
boundary condition: false

metaR THYOXt2
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
name: T4 transport via facilitated diffusion
modifier: MODEL1310110018#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110018#

metaM sbt D c
type: Species
is: HMDB00247
boundary condition: false
initial amount: NaN
name: D-glucitol
is: SBO:0000247
is: CHEBI:17924
constant: false
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0

metaR G14T8g
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction

metaR GLUTCOADHm
is: SBO:0000176
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.99.7
name: glutaryl-CoA dehydrogenase (mitochondria)
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_470691de_9a2c_47f0_a1aa_02d21bf4da3d
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:728441
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GGT2

metaM thcholstoic c
type: Species
is: SBO:0000247
is: CHEBI:18402
is: HMDB03873
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM g2m8mpdol U r
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093
initial amount: NaN
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
type: Species

metaM ksi deg20 l
is: HMDB00143
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 20
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6

metaR EAFLATOXINte
reversible: true
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is: SBO:0000185
fast: false
name: xenobiotic transport
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM ump m
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false
initial amount: NaN
name: UMP(2-)
constant: false

metaR r2112
kinetic law: MODEL1310110018#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR CYTK4
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP)(GTP)
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM retinol c
is: CHEBI:50211
is: HMDB00305
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
constant: false
name: retinol
initial concentration: 1.0

metaR r0822
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
reactant: MODEL1310110018#

metaR r0747
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true

metaM ksii core2 pre3 g
is: CHEBI:2504
boundary condition: false
has only substance units: false
is: HMDB06552
name: keratan sulfate II biosynthesis, precursor 3
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_8a3ab64a_35c4_42b4_8caf_b6dedfd4e6ce
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2876
name: GPX1
constant: false
is: P07203
initial concentration: NaN
is: SBO:0000252

metaR ACGAMtly
is: SBO:0000185
reversible: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110018#
name: N-acetyl-glucosamine lysosomal efflux
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_16ee60ec_d217_4098_adca_8a34a8822e34
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2653
name: GCSH
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P23434

metaR F6Tg
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: false
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_54cf0f00_8240_4c38_9f3b_4b42011d87ff
has only substance units: false
boundary condition: true
is: B1AK53
is: SBO:0000252
type: Species
name: ESPN
is encoded by: hsa:83715
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7059823e_d025_4ca4_a8b3_fd33e8fc728a
constant: false
initial concentration: NaN
is encoded by: hsa:84569
has only substance units: false
initial amount: NaN
name: LYZL1
boundary condition: true
type: Species
is: Q6UWQ5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_e6f1c1c3_a26f_4b07_b38f_50168cb56b77
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4191
is: P40926
boundary condition: true
name: MDH2
initial amount: NaN
type: Species
has only substance units: false

metaR AKR1D2
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110018#
reversible: false
fast: false
is described by: ECO:0000269

metaR r2114
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110018#_a0efee5a_a9d2_4fbc_b187_77d6e0ea78ae
boundary condition: true
is: P09172
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: DBH
type: Species
has only substance units: false
is encoded by: hsa:1621
constant: false

metaM tetpent6 e
is: SBO:0000247
boundary condition: false
name: tetracosapentaenoic acid, n-6
has only substance units: false
is: HMDB06322
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaR r1010
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Postulated transport reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM HC02202 e
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
name: prostaglandin A1(1-)
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57398
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_dbd99af9_f9bd_40fe_98c1_c2d5364753ef
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GBA
constant: false
initial concentration: NaN
is: P04062
is encoded by: hsa:2629
type: Species

metaM cholcoa x
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
is: SBO:0000247
is: CHEBI:57373
constant: false
initial concentration: 1.0
name: choloyl-CoA(4-)

metaR H2Otg
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110018#
fast: false
name: H2O transport, Golgi apparatus

metaR M7MASNBterg
is described by: ECO:0000000
reversible: false
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110018#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_6cf426f7_e056_4776_9681_91fcfeacabe0
is: Q9NRA0
is encoded by: hsa:56848
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: SPHK2

metaM cmpacna g
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01176
initial amount: NaN
is: CHEBI:57812
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM arachdcoa c
is: CHEBI:57368
constant: false
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB06523
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_95733d5a_ba4f_477c_bd39_7dcc07d6c983
is: SBO:0000252
is: Q9BY49
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55825
has only substance units: false
type: Species
name: PECR
initial amount: NaN

metaR GLYt2r
is described by: ECO:0000304
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
reactant: MODEL1310110018#
fast: false
name: glycine reversible transport via proton symport
is: SBO:0000185
modifier: MODEL1310110018#
type: Reaction

metaM amet c
is: CHEBI:15414
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
name: S-Adenosyl-L-methionine
is: C00019
is: HMDB01185
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r2113
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#

metaM CE5118 m
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_1605bb9b_dfbf_4d21_b4c4_e5fa6eb31f30
initial concentration: NaN
is: Q9NUB1
boundary condition: true
constant: false
type: Species
has only substance units: false
name: ACSS1
is encoded by: hsa:84532
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c48f3e16_5fa8_4c23_af03_6442a11acb68
constant: false
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true
name: PDE9A
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_5da7363c_417f_4d06_868f_943af75aed88
constant: false
name: CYP11A1
initial amount: NaN
is: G3XAD7
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1583
has only substance units: false
boundary condition: true

metaR DESAT22 1p
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_051901d0_275a_4e2c_8610_2b92897910fc
type: Species
is: Q8TE04
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PANK1
is: SBO:0000252
is encoded by: hsa:53354
boundary condition: true
constant: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR ADRNt
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
product: MODEL1310110018#

metaR GAO1g
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
name: Ganglioside O-acetylation

metaR ECOAH9m
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110018#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#

metaR r2116
is: SBO:0000185
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PI45P4P
reactant: MODEL1310110018#
fast: false
is: SBO:0000176
product: MODEL1310110018#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase

metaM pmtcrn r
is: CHEBI:17490
is: HMDB00222
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: L-palmitoylcarnitine
initial amount: NaN
has only substance units: false

metaR r0181
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

metaM fad m
is: CHEBI:16238
is: HMDB01248
has only substance units: false
is: C00016
type: Species
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM dgdp c
boundary condition: false
is: C00361
type: Species
constant: false
is: HMDB00960
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: dGDP
initial amount: NaN
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM ksii core2 pre6 g
type: Species
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d8eca231_35f9_4c14_bbc1_4943e4f270cb
constant: false
is: Q96NT5
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:113235
name: SLC46A1
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.61
fast: false
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110018#
is: SBO:0000176
reversible: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR NDPK1m
product: MODEL1310110018#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000254

metaR r2115
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
fast: false
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_7229575a_18df_4214_ab00_2cb93d4750a3
name: ENTPD2
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:954
is: Q5SPY7
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_bc32942c_e000_4319_bb9a_dca0669639e1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3939
type: Species
is: P00338
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: LDHA

metaR RE1807M
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: RE1807
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
product: MODEL1310110018#

metaR DTTPtn
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: dTTP diffusion in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
reactant: MODEL1310110018#

metaR STRDNCt
fast: false
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110018#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110018#

metaM HC02172 c
boundary condition: false
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
constant: false
is: SBO:0000247
name: Zinc
is: CHEBI:29105
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_c7fca263_d83d_4297_a56a_2e723ab163c0
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PDE11A
boundary condition: true
initial amount: NaN
is: Q9HCR9
is encoded by: hsa:50940

metaR FAOXC226m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM duri c
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
is: HMDB00012
name: Deoxyuridine
is: CHEBI:16450
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C00526
has only substance units: false
initial concentration: 1.0

metaR r2532
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR G6PPer
is version of: http://identifiers.org/ec-code/3.1.3.9
type: Reaction
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is described by: ECO:0000269
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: glucose-6-phosphate phosphatase, edoplasmic reticular
reversible: false
kinetic law: MODEL1310110018#

metaM glyphe c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Glycylphenylalanine
is: http://identifiers.org/pubchem.compound/97415
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR r2118
type: Reaction
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
product: MODEL1310110018#

metaM ahcys c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00939
constant: false
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
is: CHEBI:16680
is: SBO:0000247
initial amount: NaN
name: S-Adenosyl-L-homocysteine

metaR BDMT U
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110018#
reversible: false
is described by: ECO:0000000
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
fast: false

metaM cs e deg5 l
is: HMDB00868
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
has only substance units: false
constant: false
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial concentration: 1.0
type: Species

metaR HMGCOASim
reversible: false
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
name: Hydroxymethylglutaryl CoA synthase (ir)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269

metaR CYTK6n
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110018#
name: cytidylate kinase (CMP,CTP),nuclear
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269

metaM ump r
boundary condition: false
is: CHEBI:57865
name: UMP
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
initial concentration: 1.0
is: HMDB00288
constant: false
initial amount: NaN

metaR r2117
product: MODEL1310110018#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0829
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.1.1.37
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#

metaR r0309
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_15e4de5c_742b_48d2_b815_21db2ef49eff
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:H77542
initial amount: NaN
name: _H77542_1_r

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000

metaM HC02172 e
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:29105
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
type: Species
name: Zinc

metaM ksii core4 pre9 g
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
constant: false
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28067

metaM m8mpdol U r
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
is: SBO:0000247
is: CHEBI:59093
boundary condition: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM duri e
initial concentration: 1.0
is: SBO:0000247
is: C00526
boundary condition: false
is: CHEBI:16450
is: HMDB00012
name: Deoxyuridine
type: Species
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
constant: false

metaM HC02202 c
has only substance units: false
is: CHEBI:57398
type: Species
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin A1(1-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9f7070dd_9dd2_4936_b5e2_b2c0ac03f98b
type: Species
name: LDHD
is: SBO:0000252
constant: false
is encoded by: hsa:197257
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM cmpacna n
constant: false
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
has only substance units: false
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_0fb62d9c_7f68_4a64_af36_ab7b21eaecce
initial amount: NaN
constant: false
is: SBO:0000252
name: PCBD2
is: Q9H0N5
is encoded by: hsa:84105
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaM dag hs c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: diglyceride
is: SBO:0000247
constant: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR RE2649C
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: RE2649

http://identifiers.org/biomodels.db/MODEL1310110018#_599da0d6_0a01_458e_b612_1607ce3af182
initial concentration: NaN
type: Species
is encoded by: hsa:10768
is: SBO:0000252
name: AHCYL1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: O43865

metaM tetpent6 c
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: tetracosapentaenoic acid, n-6
type: Species
initial amount: NaN

metaM 34dhmald m
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR UMPK4n
product: MODEL1310110018#
type: Reaction
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
name: UMP kinase (GTP),nuclear
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_d69a7e3e_b25f_475e_af98_8c1cd4b4ba30
is encoded by: hsa:570
initial concentration: NaN
name: BAAT
has only substance units: false
boundary condition: true
is: Q14032
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM ahcys e
name: S-Adenosyl-L-homocysteine
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00939
type: Species
is: C00021
is: CHEBI:16680
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: SBO:0000247
initial amount: NaN

metaR S6TASE26ly
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110018#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_01458979_5177_4709_a315_fe6dcffc7655
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1808
type: Species
is: B4DR31
name: DPYSL2
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r0186
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110018#

metaR S6T15g
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#

metaR r2119
is: SBO:0000185
reversible: true
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_68b2dcdf_212c_46b2_a148_0d6829862a49
initial concentration: NaN
is encoded by: hsa:1565
type: Species
name: CYP2D6
has only substance units: false
is: Q6NXU8
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR ADSL1
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000269
name: adenylosuccinate lyase
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: false
product: MODEL1310110018#
is: SBO:0000176
type: Reaction

metaR r0937
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
name: adenosine facilated transport in cytosol
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_2a5afdce_cdac_41bc_be0b_c5a6cfc582f4
is encoded by: hsa:2582
type: Species
name: GALE
constant: false
initial concentration: NaN
is: Q38G75
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_70e741a1_55d2_41e3_9c7d_38d2a768902c
is: Q9NRD9
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:53905
initial concentration: NaN
name: DUOX1
constant: false
has only substance units: false
is: SBO:0000252

metaM 3decdicoa m
initial concentration: 1.0
constant: false
name: 3,7-decadienoylcoa
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_17951a57_7892_48c8_b4ac_31c670f8b46b
is: P49748
initial amount: NaN
boundary condition: true
name: ACADVL
is encoded by: hsa:37
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR H2Otn
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
fast: false
name: H2O transport, nuclear
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX onpthl LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: naphthalene epoxide exchange
type: Reaction

metaR GLNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110018#
is described by: ECO:0000269

metaR r0527
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#

metaM omhpal r
initial amount: NaN
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
name: w-hydroxypalmiticacid
type: Species
is: HMDB06294
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR ACACT5p
is: SBO:0000176
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110018#
fast: false
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM pmtcrn m
initial concentration: 1.0
is: HMDB00222
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
initial amount: NaN
has only substance units: false
name: L-palmitoylcarnitine
is: CHEBI:17490
boundary condition: false
type: Species

metaR RE1526M
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110018#
name: RE1526
reversible: true
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110018#_2a502be0_78dd_41f3_ac51_bc3eac5d113d
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3417
is: SBO:0000252
name: IDH1
type: Species
is: O75874
initial amount: NaN

metaR r2535
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_5c1a2d17_6962_4adb_a024_0a03b6e3a44d
is encoded by: hsa:10935
is: E9PH29
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PRDX3
constant: false
type: Species

metaR r0750
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_4e34a7c4_37db_4191_8df2_517d41ab0222
is encoded by: hsa:4597
initial concentration: NaN
boundary condition: true
constant: false
name: MVD
is: SBO:0000252
is: P53602
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_11f831b3_a6db_4b37_9869_5acf1a7f76c1
type: Species
has only substance units: false
is: Q96KH8
is encoded by: hsa:6530
constant: false
initial concentration: NaN
name: SLC6A2
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_a42b75a4_0489_4668_8aa4_d2236cbc8cef
type: Species
constant: false
is: Q15181
has only substance units: false
boundary condition: true
initial amount: NaN
name: PPA1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5464

http://identifiers.org/biomodels.db/MODEL1310110018#_99d8acf8_e571_4e17_abbe_899dbe649524
is encoded by: hsa:55825
is: SBO:0000252
is: Q9BY49
name: PECR
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR GGH 5DHFe
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: Gamma-glutamyl hydrolase (5DHF), extracellular

http://identifiers.org/biomodels.db/MODEL1310110018#_d18cb45c_77b9_4edc_870c_fee061759ad5
initial concentration: NaN
constant: false
is: P19440
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GGT1
type: Species
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110018#_4e798587_9165_4777_a0b4_418e30375521
initial concentration: NaN
name: _FLJ44968_1_m
has only substance units: false
is encoded by: hsa:FLJ44968
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_b21a74a0_1561_4219_b850_815452e67b7a
is: SBO:0000252
name: ALDH3B2
has only substance units: false
initial amount: NaN
is encoded by: hsa:222
is: P48448
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR NRPPHRtu
name: Norepinephrine uniport
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_9e659492_0c2e_437d_84da_bf93becaa567
boundary condition: true
constant: false
is: E7EML0
has only substance units: false
initial amount: NaN
is encoded by: hsa:9498
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC4A8

metaR r2534
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110018#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaM ksi deg38 l
type: Species
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 38
has only substance units: false
boundary condition: false

metaR SAMHISTA
is version of: http://identifiers.org/ec-code/2.1.1.8
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
reversible: false
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#

metaR HS2ly
reactant: MODEL1310110018#
is: SBO:0000176
fast: false
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110018#
product: MODEL1310110018#

metaR CYSGLUexR
type: Reaction
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-cysteine/L-glutamine reversible exchanger
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110018#_f99bab89_d9a4_4413_b008_9c9124545ae9
initial amount: NaN
type: Species
has only substance units: false
is: P54803
constant: false
name: GALC
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2581

metaR NRVNCt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110018#

metaR H2Otm
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reactant: MODEL1310110018#
name: H2O transport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
product: MODEL1310110018#

metaM HC01408 m
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
boundary condition: false
is: CHEBI:27648
has only substance units: false
initial concentration: 1.0
name: 3-Oxohexanoyl-CoA
is: SBO:0000247

metaM fad e
has only substance units: false
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
type: Species
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
boundary condition: false
is: CHEBI:16238
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_e876004d_4096_4e66_be4a_b1da85fa3abc
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: O75521
name: ECI2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10455

http://identifiers.org/biomodels.db/MODEL1310110018#_f098945f_3764_452c_a54d_d9e76be4db78
is encoded by: hsa:23563
is: SBO:0000252
initial concentration: NaN
name: CHST5
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ee962985_180d_496e_a4da_19df36aa5460
type: Species
is: E7EQF2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:54677
has only substance units: false
initial amount: NaN
constant: false
name: CROT

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR NDPK1n
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110018#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r0523
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
type: Reaction
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: false
product: MODEL1310110018#
fast: false

metaM tethex3 e
initial amount: NaN
is: SBO:0000247
is: HMDB02007
name: tetracosahexaenoic acid, n-3
constant: false
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
boundary condition: false
has only substance units: false
type: Species

metaR KYNATESYN
product: MODEL1310110018#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_afda08e3_7935_44fa_b846_58d704d471e2
constant: false
name: TALDO1
initial amount: NaN
is encoded by: hsa:6888
boundary condition: true
type: Species
has only substance units: false
is: P37837
is: SBO:0000252
initial concentration: NaN

metaR 3MOPte
product: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Transport of 3-methyl-2-oxopentanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM dnad c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Deamino-NAD+
boundary condition: false
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: C00857
is: HMDB01179
type: Species
has only substance units: false
is: CHEBI:18304

http://identifiers.org/biomodels.db/MODEL1310110018#_f58fe4a2_0a55_4add_9d2b_fd7fad0558fb
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: PRPS2
is: P11908
boundary condition: true
initial amount: NaN
is encoded by: hsa:5634
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2d430bca_61c9_421b_9f43_eb5165b1cabb
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:47
is: P53396
name: ACLY

metaR ETOHtx
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
name: ethanol reversible peroxisomal transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ab80c0e6_8903_4ecc_8fc8_61d7e4ff8436
has only substance units: false
is: SBO:0000252
constant: false
is: Q6LEN6
is encoded by: hsa:1103
type: Species
initial amount: NaN
initial concentration: NaN
name: CHAT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_302e602a_ef5a_4624_a206_bb2d8d8959e1
is: SBO:0000252
constant: false
is: E9PB82
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3295
initial concentration: NaN
name: HSD17B4

metaR r2539
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: Postulated transport reaction

metaR RE1807C
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
reactant: MODEL1310110018#
name: RE1807
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110018#

metaR GLYCtm
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
reactant: MODEL1310110018#
name: glycerol transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_08284909_8272_408c_911e_8c0ddcf36af6
has only substance units: false
is encoded by: hsa:51
constant: false
type: Species
name: ACOX1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q15067
initial amount: NaN

metaM cmpacna c
type: Species
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01176
is: CHEBI:57812

http://identifiers.org/biomodels.db/MODEL1310110018#_d75c3c8e_61b2_4cc9_a7e4_04ef4d25ad99
has only substance units: false
is: Q63HM1
initial amount: NaN
constant: false
is encoded by: hsa:125061
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: AFMID

metaM glyb m
is: HMDB00043
boundary condition: false
name: glycine betaine
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
initial concentration: 1.0
is: CHEBI:17750
initial amount: NaN
constant: false
has only substance units: false

metaR RE0690E
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
reactant: MODEL1310110018#
name: RE0690
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
modifier: MODEL1310110018#

metaM dgdp m
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58595
constant: false
is: HMDB00960
name: dGDP(2-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false

metaR GUAt
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
type: Reaction
fast: false
name: Guanine transport
reversible: true
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_5be518de_3547_4e83_a238_5a904cfcbdee
is: SBO:0000252
has only substance units: false
boundary condition: true
name: OGDH
is: Q02218
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4967
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_a969010b_66e4_4a48_86a5_1f4ccdd543ab
is: SBO:0000252
name: SLC38A1
is encoded by: hsa:81539
is: Q9H2H9
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM fad c
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
boundary condition: false
is: HMDB01248
type: Species
is: CHEBI:16238
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_bd8aadf3_93d8_4e68_867e_8d309c3e711f
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: PTGIS
is: Q16647
is encoded by: hsa:5740
is: SBO:0000252

metaR r2538
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110018#

metaR S6TASE19ly
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reversible: true
reactant: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction

metaR DURIPP
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: deoxyuridine phosphorylase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
product: MODEL1310110018#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_def5486c_26cc_416a_b6bd_b5d85d783413
is: Q92685
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALG3
is encoded by: hsa:10195
constant: false
boundary condition: true

metaM tethex3 c
is: HMDB02007
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
has only substance units: false
boundary condition: false
name: tetracosahexaenoic acid, n-3
type: Species
is: SBO:0000247

metaR L LACt2r
reversible: true
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110018#
name: L-lactate reversible transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR AHEXASEly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaM dgdp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
initial amount: NaN
boundary condition: false
is: CHEBI:58595
is: HMDB00960
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR r0522
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#

metaR MANter
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110018#
name: mannose efflux from endoplasmic reticulum
kinetic law: MODEL1310110018#

metaR r2537
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
name: Utilized transport
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000185
product: MODEL1310110018#

metaR DNDPt27m
product: MODEL1310110018#
is described by: ECO:0000269
name: dCDP transport via dTDP antiport
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c8e098e5_9d3c_4383_86e0_e8dea9cd8b73
initial concentration: NaN
is encoded by: hsa:2108
constant: false
is: SBO:0000297
type: Species
boundary condition: true
is encoded by: hsa:2109
initial amount: NaN
has only substance units: false
has part: P13804
name: ETFA:ETFB

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110018#
name: Malate:sulfite antiport, mitochondrial
reversible: true
is: SBO:0000185
modifier: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_13136e49_2d95_428e_9c21_d90307660354
is encoded by: hsa:6579
initial amount: NaN
boundary condition: true
name: SLCO1A2
has only substance units: false
initial concentration: NaN
constant: false
is: P46721
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_50618001_fe62_4361_8a84_fb5203d0002c
constant: false
is: SBO:0000252
initial concentration: NaN
is: P80404
name: ABAT
is encoded by: hsa:18
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR ADSL2
product: MODEL1310110018#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110018#
reversible: false
name: adenylosuccinate lyase
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269

metaR THRGLYexR
fast: false
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
kinetic law: MODEL1310110018#
is: SBO:0000185

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM ksi pre17 g
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 17
boundary condition: false
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_ae8e75e0_b39d_4a47_8d02_b07a342349d9
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9UI40
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: SLC24A2
is encoded by: hsa:25769

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#
name: Active transport
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ec1e8f2b_657f_422e_b255_895e59ede988
type: Species
is: Q92911
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6528
initial amount: NaN
constant: false
name: SLC5A5
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a853725c_e09a_4dca_b1d4_398bc94bbab6
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q99643
constant: false
is: SBO:0000252
name: SDHC
boundary condition: true
is encoded by: hsa:6391

metaM tetpent3 e
is: SBO:0000247
boundary condition: false
is: HMDB06323
name: tetracosapentaenoic acid, n-3
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaR IMPD
product: MODEL1310110018#
is described by: ECO:0000134
name: IMP dehydrogenase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.205

metaR r0732
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR DNDPt29m
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
kinetic law: MODEL1310110018#
name: dCDP transport via dADP antiport

metaR r2517
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
reversible: true
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_0e406f26_e488_4e1c_a829_282a30ed8549
initial concentration: NaN
type: Species
is encoded by: hsa:AI620219
boundary condition: true
is: SBO:0000252
constant: false
name: _AI620219_1_m
has only substance units: false
initial amount: NaN

metaR r0830
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c7c06e38_fb15_4eb9_aace_4fff67ace956
has only substance units: false
is: P31040
constant: false
type: Species
is encoded by: hsa:6389
initial amount: NaN
name: SDHA
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM dgsn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00085
is: CHEBI:17172
type: Species
is: C00330
initial concentration: 1.0
constant: false
name: Deoxyguanosine

metaR r2518
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR IMPC
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.2.3
name: IMP cyclohydrolase
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000176
reversible: true

metaR r0731
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110018#
type: Reaction

metaR G14T10g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#
fast: false

metaR r0942
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185

metaM g3p c
name: Glyceraldehyde 3-phosphate
boundary condition: false
constant: false
has only substance units: false
is: C00661
is: CHEBI:58027
is: http://identifiers.org/pubchem.compound/3930
type: Species
initial amount: NaN
is: HMDB01112
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116

metaM tetpent3 c
boundary condition: false
name: tetracosapentaenoic acid, n-3
is: SBO:0000247
has only substance units: false
is: HMDB06323
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species

metaM em2emgacpail hs r
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
is: HMDB03125
type: Species
is: CHEBI:16240
is: SBO:0000247
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false

metaR r2519
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110018#
name: Utilized transport
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000

metaR r0734
reversible: false
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR ACt2m
is: SBO:0000185
product: MODEL1310110018#
reversible: true
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110018#

metaR AG13T4g
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110018#

metaM L2aadp c
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00510
is: CHEBI:58672
initial concentration: 1.0
name: L-2-aminoadipate(1-)

http://identifiers.org/biomodels.db/MODEL1310110018#_09b1bacb_8ea0_43d2_842c_27d1e28dfbfc
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: ABP1
is encoded by: hsa:26
is: P19801

metaR r0941
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Free diffusion

metaM amet r
has only substance units: false
name: S-adenosyl-L-methionine
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:15414
initial amount: NaN
constant: false
is: HMDB01185

metaR CITL
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Citrate lyase
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_7921c900_79c6_41eb_be4a_3d8ca1bd3543
name: HPRT1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3251
boundary condition: true
initial amount: NaN
is: P00492

metaM ksi pre22 g
is: HMDB06552
constant: false
type: Species
boundary condition: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial amount: NaN
is: CHEBI:2504
name: keratan sulfate I biosynthesis, precursor 22
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_25345909_96d2_46cd_b15c_60c358f45ca8
is: SBO:0000252
is encoded by: hsa:5152
type: Species
name: PDE9A
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR CREATt4 2 r
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
name: Creatine transport (sodium symport) (2:1)
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
fast: false

metaR NCNt
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110018#

metaM 3pg m
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
is: CHEBI:58272
initial concentration: 1.0
is: HMDB00807
constant: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197

metaR r0733
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM lneldccrn c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
name: Linoelaidyl carnitine
constant: false
is: HMDB06461
initial amount: NaN
has only substance units: false
type: Species

metaR ASPPROASCT1
product: MODEL1310110018#
type: Reaction
is: SBO:0000185
name: aspartate intake by system ASCT-1 transporter
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
is described by: ECO:0000134
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM apoC Lys m
is: HMDB00182
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
initial concentration: 1.0
initial amount: NaN
name: Apocarboxylase (Lys residue)
is: SBO:0000247

metaR TXA2te
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
product: MODEL1310110018#
is: SBO:0000185
reversible: true
name: thromboxane A2 transport
kinetic law: MODEL1310110018#
is described by: ECO:0000000
fast: false

metaM itaccoa m
name: itaconyl-CoA(5-)
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57381
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531

metaR SCP21x
is: SBO:0000185
modifier: MODEL1310110018#
product: MODEL1310110018#
name: Sterol carrier protein 2
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
fast: false
kinetic law: MODEL1310110018#

metaR VACCt
fast: false
type: Reaction
reactant: MODEL1310110018#
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110018#_32cde3ca_568d_4757_8e45_ce9a65ac8a08
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PLCB1
is: Q9NQ66
is encoded by: hsa:23236

metaR RDH3a
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: retinol dehydrogenase (11-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_270fc1c5_9b3f_486d_a89d_95ba61eb00cb
name: CYP1A2
has only substance units: false
is encoded by: hsa:1544
type: Species
boundary condition: true
is: P05177
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_b318a366_c3b4_4c20_a6e2_2da33770bddb
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110018#_4f066595_be25_457c_ae34_a1ef0c95d289
type: Species
name: DBT
is: P11182
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1629
constant: false

metaR NDPK1
product: MODEL1310110018#
name: nucleoside-diphosphate kinase (ATP:GDP)
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
modifier: MODEL1310110018#
reactant: MODEL1310110018#

metaM CE0849 m
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: CHEBI:57795
initial amount: NaN
type: Species
initial concentration: 1.0
name: cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247

metaR SERCYSNaEx
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110018#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
fast: false

metaM 6dhf e
constant: false
is: HMDB06563
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: hexaglutamyl folate (DHF)

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR RE0827E
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: RE0827

http://identifiers.org/biomodels.db/MODEL1310110018#_32718fdb_e75d_4f54_b26b_2b02e1eca40d
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: PANK2
is: Q9BZ23
is encoded by: hsa:80025

metaR FACOAL1812
reversible: true
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000000
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM nadph r
is: C00005
is: HMDB00221
type: Species
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57783
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
boundary condition: false

metaM ksi pre16 g
is: CHEBI:2504
type: Species
is: HMDB06552
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 16
initial concentration: 1.0
initial amount: NaN

metaR r1177
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR NDP3ex
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
type: Reaction
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000269

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:27647
name: prostaglandin-g2

http://identifiers.org/biomodels.db/MODEL1310110018#_053953cd_adad_4bde_acf1_920e0c6e83bf
is: P00568
name: AK1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:203
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaM CE0693 m
initial amount: NaN
is: SBO:0000247
is: HMDB11123
is: CHEBI:28387
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d128fe3d_d14b_48ea_8e22_e7ce23f0b239
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000297
name: EHHADH:ACAA1:ACOX1
has part: Q9NY65
is encoded by: hsa:1962
initial amount: NaN
boundary condition: true

metaR FBP
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
name: fructose-bisphosphatase
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b29d07e4_b22b_48c4_9225_adf37b2916ab
constant: false
initial concentration: NaN
is: P04040
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:847
type: Species
is: SBO:0000252
name: CAT

metaR SO4tl
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
name: Sulfate transport (lysosome)
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_19861b7d_2f32_40a7_be1b_c0d170c651b4
boundary condition: true
is: P05062
is encoded by: hsa:229
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: ALDOB
initial concentration: NaN

metaR FAOXC16C14m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_4ee4e9f8_4aec_4076_a5bf_64e55b4279d1
is encoded by: hsa:4713
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P17568
is: SBO:0000252
name: NDUFB7

metaR r0946
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM ksii core2 deg9 l
constant: false
type: Species
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C30H50N3O20X CHARGE: 0
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: CHEBI:12936
has only substance units: false

metaR NDPK3
product: MODEL1310110018#
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2b230720_a0bf_4e60_8cfe_c78a03ed4c9c
is encoded by: hsa:112724
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: B3KVA3
name: RDH13
initial concentration: NaN

metaR r0730
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction

metaM 3hmbcoa m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
is: CHEBI:57312
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)

metaR EHGLATm
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000212
reversible: false
kinetic law: MODEL1310110018#
type: Reaction

metaM ksii core4 deg3 l
initial amount: NaN
constant: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: HMDB00143
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_17e20e3c_b5f8_42f9_9846_7f86c686d28f
is: SBO:0000252
type: Species
is encoded by: hsa:5336
name: PLCG2
constant: false
initial amount: NaN
is: P16885
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM dgsn c
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00085
initial concentration: 1.0
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
boundary condition: false
type: Species
name: Deoxyguanosine
has only substance units: false

metaR EX adprib LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose exchange
type: Reaction

metaM HC02217 e
initial concentration: 1.0
has only substance units: false
name: prostaglandin-g2
type: Species
is: CHEBI:27647
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

http://identifiers.org/biomodels.db/MODEL1310110018#_1cb5587b_19a4_40ca_8515_811bc2d438e5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9091
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: B2RAU6
name: PIGQ
has only substance units: false

metaR MCLACCYSR
type: Reaction
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reactant: MODEL1310110018#
name: 3-mercaptolactate:cysteine reductase
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_99fbbbac_06c3_4bf8_9c50_53180cd3fea3
is: P00390
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GSR
constant: false
is encoded by: hsa:2936
is: SBO:0000252

metaM gm3 hs g
is: CHEBI:60065
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: SBO:0000247

metaM xmp c
name: Xanthosine 5'-phosphate
type: Species
constant: false
is: SBO:0000247
is: HMDB01554
initial amount: NaN
is: C00655
boundary condition: false
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: CHEBI:57464
initial concentration: 1.0
has only substance units: false

metaR NDPK2
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_b955f64a_607c_47f5_b83e_092b5664b658
type: Species
is encoded by: hsa:84720
constant: false
is: Q8TEQ8
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PIGO
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_7ec2d50c_af1c_4de8_8d19_8ec69ac0bffd
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5140
initial amount: NaN
type: Species
is: A7E2E5
name: PDE3B
has only substance units: false
is: SBO:0000252

metaR EICOSTETt
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110018#

metaR r0839
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: Postulated transport reaction
fast: false
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction

metaM 5fthf m
is: CHEBI:57457
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01562
has only substance units: false
name: 5-formyltetrahydrofolate(2-)
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_80601d46_6b24_49f6_a9bb_fed627b57bd2
constant: false
initial concentration: NaN
boundary condition: true
name: TXNRD3
is encoded by: hsa:114112
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q86VQ6

http://identifiers.org/biomodels.db/MODEL1310110018#_ef940ccd_1e0b_4941_8e22_6c293de45055
name: ADA
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:100
constant: false
boundary condition: true
is: P00813
initial concentration: NaN
has only substance units: false

metaM apoC Lys c
notes: FORMULA: C6H13N2OX CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB00182
name: Apocarboxylase (Lys residue)
is: CHEBI:32551
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM clpnd e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
name: clupanodonic acid
is: HMDB06528
is: CHEBI:53488
is: SBO:0000247
constant: false
has only substance units: false

metaR FAOXC184m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR C3STDH1Pr
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)

metaM ahcys r
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00939
constant: false
name: S-adenosyl-L-homocysteine
boundary condition: false
has only substance units: false

metaM glyphe e
is: http://identifiers.org/pubchem.compound/97415
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: Glycylphenylalanine

metaR r0838
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
fast: false
name: Free diffusion
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
kinetic law: MODEL1310110018#

metaR LACZe
is described by: ECO:0000134
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
name: b-galactosidase, extracellular
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.108

metaR ORNtiDF
is: SBO:0000185
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: ornithine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
kinetic law: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_17866d54_67d6_43d5_bc72_3dd110b78cfc
is: SBO:0000252
is encoded by: hsa:8706
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: Q49AT3
has only substance units: false
name: B3GALNT1

metaR ECOAH12m
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
kinetic law: MODEL1310110018#

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
type: Reaction
is described by: ECO:0000000
name: glycine passive transport to peroxisome
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
fast: false

metaR r0739
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110018#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_bf7f1e2d_4387_40e9_8655_82b5bba9060a
type: Species
is: SBO:0000252
is encoded by: hsa:5152
initial amount: NaN
name: PDE9A
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM omhpal c
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
initial amount: NaN
name: w-hydroxypalmiticacid
is: HMDB06294
type: Species
boundary condition: false

metaM dgchol c
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: glycochenodeoxycholate
type: Species
is: CHEBI:36252
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637

http://identifiers.org/biomodels.db/MODEL1310110018#_2eba566d_171e_4768_b6aa_77d9b9001e8e
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23007
type: Species
name: PLCH1
initial amount: NaN
initial concentration: NaN
is: Q4KWH8

http://identifiers.org/biomodels.db/MODEL1310110018#_a4c912f9_4682_4e5a_8afc_4bcec44bcdf0
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: AKR1B1
boundary condition: true
is: P15121
is encoded by: hsa:231
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_93262437_b5e0_4430_be67_a6a6830644e3
is: P50993
name: ATP1A2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:477
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_93ba2ae5_37e9_4e5b_9ff4_979556971376
boundary condition: true
is: SBO:0000252
name: LIPC
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: A6H8L5
initial concentration: NaN
is encoded by: hsa:3990

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR RBTt
type: Reaction
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
name: ribitol transport via passive diffusion
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_982a11bb_dee6_43d8_979d_06091a2e9de7
initial amount: NaN
name: HAGH
constant: false
is encoded by: hsa:3029
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: Q16775

metaR RETH
is version of: http://identifiers.org/ec-code/3.1.1.3
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
name: retinyl ester hydrolase
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110018#_3f94b0b1_4024_4b58_93fa_c6fd902b6128
is: SBO:0000252
type: Species
is: Q9H0P0
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51251
has only substance units: false
constant: false
initial amount: NaN
name: NT5C3

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR RE3273C
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
reactant: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.4
name: RE3273
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false

metaR CORE3GTg
kinetic law: MODEL1310110018#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
reversible: false
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_de2bc923_ad35_476f_a0cd_b007d0e9c4d6
name: PRPS1L1
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:221823
initial concentration: NaN
has only substance units: false

metaR 4HDEBRISOQUINEte
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
fast: false
name: xenobiotic transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaR r0836
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction

metaR HMGCOARc
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
modifier: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
reversible: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM leuktrA4 e
constant: false
initial concentration: 1.0
name: leukotriene A4(1-)
is: CHEBI:57463
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species
is: HMDB01337
boundary condition: false

metaM g3pc c
is: CHEBI:16870
name: sn-Glycero-3-phosphocholine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00086
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
constant: false
type: Species
has only substance units: false

metaM glyc R c
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
is: CHEBI:16659
is: HMDB00139
name: D-glycerate
type: Species
initial concentration: 1.0

metaR GUAPRT
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
type: Reaction
name: guanine phosphoribosyltransferase
is: SBO:0000176
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_e1d7c283_158a_465a_8266_33d1e2aa0b21
is encoded by: hsa:5333
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: P51178
name: PLCD1
is: SBO:0000252

metaM ahcys m
initial concentration: 1.0
has only substance units: false
name: S-Adenosyl-L-homocysteine
boundary condition: false
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: C00021
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB00939

metaR r0835
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a07225f2_71e9_489a_a21b_4054482cc429
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:686
constant: false
type: Species
is: P43251
name: BTD
initial amount: NaN
has only substance units: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_3cdf5ea8_8644_4f9c_85f3_99885e6862be
boundary condition: true
type: Species
has only substance units: false
name: PPA2
initial amount: NaN
is: F8WDN9
is encoded by: hsa:27068
initial concentration: NaN
constant: false
is: SBO:0000252

metaM 3pg c
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00197
is: CHEBI:58272
has only substance units: false
name: 3-Phospho-D-glycerate
is: HMDB00807

metaM 2mcit e
initial amount: NaN
constant: false
is: CHEBI:15598
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: HMDB00379
is: SBO:0000247
has only substance units: false
name: 2-methylcitrate(3-)
boundary condition: false
initial concentration: 1.0
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM amet m
initial concentration: 1.0
is: HMDB01185
name: S-Adenosyl-L-methionine
has only substance units: false
is: C00019
is: CHEBI:15414
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

metaR r0940
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: Free diffusion
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110018#
type: Reaction

metaR MCITS
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
product: MODEL1310110018#
name: 2-methylcitrate synthase
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#

metaR DHCR72r
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.1.21
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
name: 7-dehydrocholesterol reductase
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#

metaR UDPDOLPT U
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.117
kinetic law: MODEL1310110018#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is: SBO:0000176
modifier: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction

metaR LYStip
name: L-lysine transport, peroxisomal (irreversible)
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_653f02dd_4c16_45e9_acfb_fafadc5eaa85
is encoded by: hsa:AU149534
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AU149534_1_c
boundary condition: true

metaM abt e
is: HMDB01851
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial concentration: 1.0
is: CHEBI:18403
name: L-arabinitol
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_7ba2b8a9_9fe3_4045_b9a9_9b4a6598ca59
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6241
constant: false
name: RRM2
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P31350

metaR r2100
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110018#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR r0735
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
type: Reaction
is: SBO:0000176

metaM HC01118 r
boundary condition: false
constant: false
is: CHEBI:57310
initial concentration: 1.0
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
name: presqualene diphosphate(3-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR HS4ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110018#
fast: false
type: Reaction
modifier: MODEL1310110018#
name: heparan-N-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110018#_e002d44e_a565_4ec8_a187_23bbaab89a19
initial amount: NaN
type: Species
name: GCNT4
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q9P109
is encoded by: hsa:51301
is: SBO:0000252

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR AG13T15g
is: SBO:0000176
reactant: MODEL1310110018#
reversible: false
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM Ssq23epx r
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:15441
is: HMDB01188
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
name: (S)-2,3-epoxysqualene
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM duri n
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: HMDB00012
name: 2'-deoxyuridine

http://identifiers.org/biomodels.db/MODEL1310110018#_e414a7d2_9100_4d0f_b0d4_b3e33359f43b
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6519
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SLC3A1
is: Q07837

metaR LTC4CP
type: Reaction
name: Leukotriene C4 carboxypeptidase
reversible: true
product: MODEL1310110018#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is described by: ECO:0000000
reactant: MODEL1310110018#

metaM succ c
is: CHEBI:30031
type: Species
constant: false
is: C00042
name: Succinate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00254
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR TALA
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110018#
name: transaldolase
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.2
reversible: true
fast: false

metaM 6pgc r
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
name: 6-phosphonatooxy-D-gluconate
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58759
is: HMDB01316
boundary condition: false

metaM glc D r
is: HMDB00122
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
initial amount: NaN
type: Species
name: D-glucose
is: CHEBI:4167
constant: false
boundary condition: false
has only substance units: false

metaR THRGLNexR
modifier: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_59508764_38f6_461b_b587_444b4745f310
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM chol n
is: HMDB00097
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:15354
name: choline

metaM hgentis c
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
name: homogentisate
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: HMDB00130
initial amount: NaN
constant: false
is: CHEBI:16169
is: SBO:0000247

metaM chol m
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00097
is: CHEBI:15354
constant: false
initial concentration: 1.0
name: choline

metaR G14T7g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
type: Reaction
modifier: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.13
name: hydrolysis of cholesterol ester by cholesterol esterase
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000134

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_d3f48433_4292_4a3d_a86c_1f6163020b3d
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10768
initial amount: NaN
name: AHCYL1
constant: false
boundary condition: true

metaR q10h2tc
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000134

metaM 2mcit c
has only substance units: false
is: HMDB00379
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:15598
type: Species
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_9cecaad9_d1a1_40b6_8910_7626bbc3df45
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:389015
is: Q6AI14
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: SLC9A4

metaM abt c
name: L-arabinitol
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB01851
is: CHEBI:18403
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
is: SBO:0000247

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
is: HMDB00221
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_402ff596_8029_4e02_a9b2_4620a9658ba7
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4645
name: MYO5B
initial amount: NaN
is: Q9H6Y6

http://identifiers.org/biomodels.db/MODEL1310110018#_2fa0cdb6_38e1_49e6_8d3c_ffbed0e08a91
type: Species
initial concentration: NaN
is: F8WDN9
has only substance units: false
name: PPA2
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:27068

metaR CRVNCtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110018#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaR ACt2r
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: true
fast: false
is described by: ECO:0000000
name: acetate reversible transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_d2e33268_13e0_4a88_9d69_7477c05af1e9
is encoded by: hsa:8654
has only substance units: false
name: PDE5A
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: G5E9C5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_98283eea_f792_48fc_8ce6_dfeed1a729c2
is: P59796
is: SBO:0000252
name: GPX6
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:257202

http://identifiers.org/biomodels.db/MODEL1310110018#_d4ca8a78_6f84_4fc0_be16_b01d73554025
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI440329
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: _AI440329_1_r

metaM asp D x
boundary condition: false
name: D-aspartate(1-)
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
is: CHEBI:29990
is: HMDB06483
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_13522c85_23c2_46f9_bb7f_c7fa511b7339
name: ACOT4
is encoded by: hsa:122970
type: Species
is: Q8N9L9
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_f4082377_0a94_4ccc_bd2e_a1b43088e86f
constant: false
has only substance units: false
boundary condition: true
name: RDH11
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51109
is: SBO:0000252
is: B4DDW0

metaM pmtcrn x
boundary condition: false
is: CHEBI:17490
type: Species
is: SBO:0000247
name: L-palmitoylcarnitine
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
initial amount: NaN
initial concentration: 1.0

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110018#
fast: false
name: lipid, flip-flop intracellular transport
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaR NDP7er
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000

metaM glyc R m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
type: Species
is: HMDB00139
initial amount: NaN
initial concentration: 1.0
name: D-glycerate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_aef45a2d_07b5_4bd1_9702_9604169e6e0e
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CHAT
boundary condition: true
is: Q6LEN6
initial amount: NaN
type: Species
constant: false

metaM ksi pre7 g
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:2504
boundary condition: false
initial concentration: 1.0
is: HMDB06552
name: keratan sulfate I biosynthesis, precursor 7
has only substance units: false
constant: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110018#_127f28cb_5ab2_4810_ae67_6de9c2c97f08
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: PEMT
has only substance units: false
is: Q9UBM1
is encoded by: hsa:10400

metaR SO4CLtex2
is described by: ECO:0000304
fast: false
reversible: false
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)

http://identifiers.org/biomodels.db/MODEL1310110018#_7b74ea60_146a_476d_a7fa_c627359d19a9
initial concentration: NaN
is: Q549M5
boundary condition: true
initial amount: NaN
is encoded by: hsa:4718
constant: false
type: Species
is: SBO:0000252
name: NDUFC2
has only substance units: false

metaM HC02180 c
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28728
initial amount: NaN
name: thromboxane-b2
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR FAOXC225m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR r0193
reversible: true
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
type: Reaction
fast: false
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

metaM oagd3 hs c
initial amount: NaN
is: SBO:0000247
name: 9-O-Acetylated GD3
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:58367
is: HMDB00286
has only substance units: false
constant: false
type: Species
is: C00029

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM 4mop e
type: Species
is: HMDB00695
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 4-methyl-2-oxopentanoate
initial amount: NaN
is: CHEBI:17865
is: SBO:0000247
has only substance units: false
constant: false

metaR NDPK2n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
type: Reaction
reversible: true
reactant: MODEL1310110018#

metaR r1020
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
fast: false
reversible: true
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_9120a449_e837_45b2_bb78_585bff9a8a27
is: Q9P1E4
initial concentration: NaN
name: MAN2A2
type: Species
is encoded by: hsa:4122
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
product: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_7a1bca26_79cd_4a9e_9669_9e80e0ff2659
is: SBO:0000252
is encoded by: hsa:R33828
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: _R33828_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b9438379_2925_4012_8339_5d427a70cd9a
constant: false
is: Q96P26
has only substance units: false
type: Species
is encoded by: hsa:93034
initial concentration: NaN
initial amount: NaN
name: NT5C1B
boundary condition: true
is: SBO:0000252

metaM na1 c
has only substance units: false
constant: false
is: CHEBI:4541
is: C01330
is: SBO:0000247
is: HMDB00588
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: Na CHARGE: 1
name: Sodium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_89d05b16_24b3_4f96_9d25_6ad2ff06ef5e
has only substance units: false
initial concentration: NaN
constant: false
is: Q6IB04
is encoded by: hsa:5281
is: SBO:0000252
boundary condition: true
type: Species
name: PIGF
initial amount: NaN

metaM nrpphr e
is: CHEBI:33569
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine

metaM hs deg12 l
boundary condition: false
is: SBO:0000247
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: CHEBI:17180
initial concentration: 1.0
name: heparan sulfate, degradation product 12
type: Species
constant: false
is: HMDB01352
has only substance units: false
initial amount: NaN

metaM HC02180 e
is: CHEBI:28728
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial concentration: 1.0
name: thromboxane-b2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_5fa0681b_8769_4f49_99e7_62bc83cecd74
is: SBO:0000252
constant: false
name: SLC20A2
boundary condition: true
initial amount: NaN
has only substance units: false
is: B2RBR4
is encoded by: hsa:6575
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_8ede0320_a30b_4596_841d_90265da06388
is encoded by: hsa:11046
initial concentration: NaN
constant: false
boundary condition: true
is: Q76EJ3
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC35D2

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR COAtr
name: COA transporter, endoplasmic reticulum
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR RETI2
reactant: MODEL1310110018#
name: retinol isomerase (9-cis)
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
fast: false
reversible: true
type: Reaction
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_cd703cdd_29a3_4126_a056_be3706c68400
boundary condition: true
initial amount: NaN
name: SOD1
is encoded by: hsa:6647
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P00441
type: Species

metaR DESAT22 2p
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM 2amac c
is: HMDB03609
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
boundary condition: false
name: 2-aminoacrylic acid
initial amount: NaN
is: CHEBI:17123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e958bc37_7536_4a64_a765_d3c0e2ebfeba
initial amount: NaN
has only substance units: false
is: Q7GXY9
constant: false
boundary condition: true
type: Species
name: ND2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4536

http://identifiers.org/biomodels.db/MODEL1310110018#_5bb31e22_49d6_40ca_bb88_823dd52a424f
initial concentration: NaN
name: PDE9A
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
type: Species
initial amount: NaN
constant: false

metaM nadph c
is: C00005
is: HMDB00221
boundary condition: false
constant: false
is: CHEBI:57783
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
initial amount: NaN
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaM thcholstoic x
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: CHEBI:18402
initial amount: NaN
is: SBO:0000247
is: HMDB03873
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

metaM 4mop c
is: SBO:0000247
type: Species
constant: false
is: HMDB00695
initial concentration: 1.0
boundary condition: false
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
is: CHEBI:17865
initial amount: NaN

metaR r2102
is: SBO:0000185
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is described by: ECO:0000000

metaR CYOR u10m
modifier: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110018#
type: Reaction
fast: false

metaM oagd3 hs e
is: SBO:0000247
name: 9-O-Acetylated GD3
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB02168
type: Species
is: CHEBI:18421
initial amount: NaN
has only substance units: false

metaR ALAt2r
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110018#
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110018#

metaR PI45P5P
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
modifier: MODEL1310110018#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR RETI1
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000000
name: retinol isomerase (11-cis)
type: Reaction
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR NACHEX20ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR UMPK5n
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110018#
name: UMP kinase (dATP),nuclear
type: Reaction
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110018#
is: SBO:0000176

metaR TRDR
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
name: thioredoxin reductase (NADPH)
modifier: MODEL1310110018#
is described by: ECO:0000269

metaM nrpphr c
is: CHEBI:33569
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
name: Norepinephrine
is: HMDB00216

metaM glc D e
has only substance units: false
initial concentration: 1.0
type: Species
name: D-glucose
is: SBO:0000247
is: CHEBI:4167
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: HMDB00122
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_af98c345_ee49_4e43_a95d_b1f7f9963bb7
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q08499
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5144
type: Species
name: PDE4D
constant: false

metaR r0196
reversible: true
reactant: MODEL1310110018#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e2a955d5_aa11_47d5_ad2d_b40fa652d404
boundary condition: true
is encoded by: hsa:LOC374569
has only substance units: false
name: _LOC374569_1_e
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r2101
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false

metaR RE2974C
fast: false
kinetic law: MODEL1310110018#
name: RE2974
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.149
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: true
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110018#

metaM apoC m
is: CHEBI:32551
is: SBO:0000247
name: Apocarboxlase (no lys residue)
notes: FORMULA: XH CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00182
initial amount: NaN
type: Species

metaR NDPK2m
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000254
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_97abf3b0_e5ef_491c_9dcb_c924482a433c
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: FOLR1
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_df3e3fab_bb25_4bf5_a091_8e681beeabd2
type: Species
is encoded by: hsa:7378
constant: false
initial amount: NaN
boundary condition: true
is: Q16831
has only substance units: false
initial concentration: NaN
name: UPP1
is: SBO:0000252

metaR r0517
is: SBO:0000176
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Sedoheptulose 7-phosphate
is: HMDB01068
has only substance units: false
is: C05382
initial concentration: 1.0
is: CHEBI:57483
constant: false
type: Species

metaM glc D l
is: HMDB00122
initial amount: NaN
is: SBO:0000247
constant: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
has only substance units: false
is: CHEBI:4167
boundary condition: false
type: Species

metaM leuktrA4 c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57463
constant: false
is: SBO:0000247
boundary condition: false
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
has only substance units: false
type: Species

metaR 3MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185

metaM 2obut m
is: HMDB00005
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
initial concentration: 1.0
is: CHEBI:16763
name: 2-oxobutanoate

metaR r2108
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR NACHEX3ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#

metaR HEX1
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
reversible: false
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000134

metaR IZPN
type: Reaction
reversible: false
reactant: MODEL1310110018#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110018#
name: Imidazolonepropionase

http://identifiers.org/biomodels.db/MODEL1310110018#_565ff34b_ec67_4b92_a713_7126ed06c8e8
is: P51841
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2986
name: GUCY2F
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_b1f4d6f7_f38c_4dd4_9156_2a622552dfd2
type: Species
is encoded by: hsa:286297
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _286297_1_c
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_64f50278_b598_4e9c_8bdd_5d9b789ea356
name: CYP3A5
is encoded by: hsa:1577
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q7Z3N0
type: Species
initial amount: NaN

metaR MALSO4tm
name: Malate:sulfate antiport, mitochondrial
fast: false
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110018#

metaM adn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
name: Adenosine
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: C00212
initial concentration: 1.0
is: HMDB00050
is: SBO:0000247

metaM oagd3 hs g
is: C00029
boundary condition: false
is: SBO:0000247
is: HMDB00286
has only substance units: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58367
constant: false
name: 9-O-Acetylated GD3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_863a7710_0451_48f8_bf0c_cf51cc6f8c73
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: SHMT1
is: P34896
constant: false
is encoded by: hsa:6470

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_40f9ac14_41ec_47fb_818b_1352c92fb0c1
has part: P48728
is encoded by: hsa:2653
has part: P23378
constant: false
initial concentration: NaN
has part: P23434
is encoded by: hsa:275
name: DLD:GCSH:GLDC:AMT
boundary condition: true
is encoded by: hsa:2731
initial amount: NaN
is: SBO:0000297
has only substance units: false
type: Species

metaR 2AMACHYD
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
name: 2-Aminoacrylate hydrolysis
is described by: ECO:0000000
kinetic law: MODEL1310110018#

metaM adn c
initial concentration: 1.0
constant: false
name: Adenosine
is: SBO:0000247
is: HMDB00050
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
is: CHEBI:16335
is: C00212
type: Species
boundary condition: false

metaR CYTK5n
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_45f64695_1f6b_4fd6_bbab_b18280e640dc
is: Q92569
type: Species
initial amount: NaN
name: PIK3R3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:8503
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_fd705481_9f7b_40c5_880b_3566686c49f7
boundary condition: true
name: _7359_1_c
type: Species
has only substance units: false
constant: false
is encoded by: hsa:7359
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM xoltriol c
boundary condition: false
type: Species
has only substance units: false
is: HMDB01457
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial concentration: 1.0
is: CHEBI:16496
constant: false
is: SBO:0000247

metaR r2107
is: SBO:0000185
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110018#
is described by: ECO:0000000

metaM CE2420 m
type: Species
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial concentration: 1.0
constant: false
is: HMDB11123
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: SBO:0000247
is: CHEBI:28387
has only substance units: false

metaR DM ethamp r
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR COAtn
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
reversible: true
name: coenzyme A transport, nuclear
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_d7d924f1_26ce_4213_9ddb_be24f4ed04a7
is: P16930
is encoded by: hsa:2184
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: FAH
is: SBO:0000252
boundary condition: true

metaR DADA
kinetic law: MODEL1310110018#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
name: Deoxyadenosine deaminase
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110018#

metaM ksi pre18 g
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB06552
is: CHEBI:2504

metaM succ m
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
is: SBO:0000247
is: HMDB00254
has only substance units: false
name: Succinate
is: CHEBI:30031
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_537c53dc_3d10_4167_8043_7143676113d5
boundary condition: true
initial amount: NaN
is encoded by: hsa:4700
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: P56556
name: NDUFA6

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR ALCD21 L
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110018#
type: Reaction
reversible: false
is: SBO:0000176
name: alcohol dehydrogenase (L-1,2-propanediol)
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaR r2106
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
product: MODEL1310110018#
type: Reaction
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_0b84ab0d_0e18_4245_9858_6865491efb06
name: CPT1A
is: Q8WZ48
initial amount: NaN
is encoded by: hsa:1374
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR r2520
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true
kinetic law: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reactant: MODEL1310110018#

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b2037fd4_7008_4360_ab85_1f4fdb5bb086
type: Species
is: SBO:0000252
name: PIP5K1B
initial concentration: NaN
boundary condition: true
constant: false
is: O14986
initial amount: NaN
has only substance units: false
is encoded by: hsa:8395

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM HC01231 m
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM na1 e
is: C01330
initial concentration: 1.0
has only substance units: false
is: HMDB00588
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
name: Sodium
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_06c72d56_9103_4d8a_9835_fba14958cb07
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:7296
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: TXNRD1

metaR PFK26
type: Reaction
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
modifier: MODEL1310110018#
name: 6-phosphofructo-2-kinase
is version of: http://identifiers.org/ec-code/2.7.1.105
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000176
product: MODEL1310110018#

metaR RE1691M
name: RE1691
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.8.1.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reversible: true

metaM clpnd c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
is: HMDB06528
constant: false
has only substance units: false
is: CHEBI:53488
initial amount: NaN
type: Species
name: clupanodonic acid

http://identifiers.org/biomodels.db/MODEL1310110018#_c39d9aed_41cc_425c_94b7_a0689fd6054c
is: O43678
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4695
has only substance units: false
is: SBO:0000252
name: NDUFA2

metaM tddedi2coa m
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C08260
type: Species
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB00672
name: trans2,6dodecadienoylcoa
boundary condition: false

metaR r2105
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_f1f57a0b_1125_485e_8a05_d55aea515c27
is: SBO:0000252
initial amount: NaN
name: CYP27A1
is encoded by: hsa:1593
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q02318
type: Species

metaR COAtp
reversible: true
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000185
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR S6T14g
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176

metaM CE5132 c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ff404c3b_e173_41bc_921b_a19867f2003e
is encoded by: hsa:55
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P15309
name: ACPP
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR ACACT10m
reversible: true
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is described by: ECO:0000134
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_40ee9478_02a4_4326_a997_9a7bce30e05a
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: MOXD1
is: Q6UVY6
is encoded by: hsa:26002
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ae17b51f_ccc2_4df5_a683_af0ab84856b7
is: P49189
is: SBO:0000252
initial amount: NaN
name: ALDH9A1
is encoded by: hsa:223
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM 13 cis retn r
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
boundary condition: false
is: D00348
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
name: 13-cis-retinoate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_04654858_1c41_47d3_90c3_566cca218fe8
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:55568
is: SBO:0000252
name: GALNT10
initial concentration: NaN
constant: false
type: Species

metaR HEXCt
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaM apoC c
is: CHEBI:33190
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: XH CHARGE: 0
name: Apocarboxlase (no lys residue)
boundary condition: false
has only substance units: false
is: HMDB11111

metaM 4mop m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17865
constant: false
boundary condition: false
is: HMDB00695
has only substance units: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
name: 4-methyl-2-oxopentanoate

metaM gly c
type: Species
has only substance units: false
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: C00037
constant: false
is: HMDB00123
name: Glycine
is: SBO:0000247
boundary condition: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR r0514
type: Reaction
reversible: false
is: SBO:0000176
fast: false
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
reactant: MODEL1310110018#

metaR r2521
is: SBO:0000185
name: Utilized transport
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110018#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR CYSGLNNaEx
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110018#

metaR RE1525M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: true
type: Reaction
name: RE1525
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176

metaR HEX4
name: hexokinase (D-mannose:ATP)
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110018#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975

http://identifiers.org/biomodels.db/MODEL1310110018#_c037f85e_279c_46d4_99c1_895287855ca8
is: SBO:0000252
name: B4GALT3
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8703
initial concentration: NaN
is: A8K5Z0
initial amount: NaN

metaR XOL7AONEtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110018#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR ITCOAL1m
is described by: ECO:0000304
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110018#_7a0c0351_a5d8_4fe2_b132_695f9d4d044e
is encoded by: hsa:27124
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: INPP5J
is: SBO:0000252
constant: false
type: Species

metaM nadph m
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: C00005
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
is: CHEBI:57783
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0

metaM m3mpdol U c
is: SBO:0000247
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
has only substance units: false
initial concentration: 1.0
is: CHEBI:37632
constant: false
type: Species
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
boundary condition: false
initial amount: NaN

metaM Rtotal3 e
is: CHEBI:3554
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00244
name: R total 3 position
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
type: Species
is: C00255

metaR COAtm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110018#
name: CoA transporter
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7413cc04_54a9_4337_b58a_b5eb2176b64d
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: P11586
initial amount: NaN
name: MTHFD1
is: SBO:0000252
is encoded by: hsa:4522

metaR THBPT4ACAMDASE
reversible: false
is: SBO:0000176
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/4.2.1.96
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false

metaR CYTK14n
is described by: ECO:0000269
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
type: Reaction
fast: false
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110018#_738d5cf8_9bf7_4075_be44_bc5534c61787
is encoded by: hsa:3945
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: P07195
has only substance units: false
is: SBO:0000252
constant: false
name: LDHB

metaR CERT1gt
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
fast: false
reversible: true
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_080f42ea_13c2_4cde_929d_c507ce18b79c
type: Species
is encoded by: hsa:2821
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P06744
constant: false
initial amount: NaN
name: GPI

metaM psylchol e
boundary condition: false
is: http://identifiers.org/pubchem.compound/94244
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
type: Species
constant: false
name: psillium-glycocholic acid complex
initial concentration: 1.0

metaR PNTEH
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110018#
name: Hydrolase Class ( RXN R02973)
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM

http://identifiers.org/biomodels.db/MODEL1310110018#_91e21687_684b_45ba_8ee3_390d98d328ae
has only substance units: false
is: P43007
is encoded by: hsa:6509
type: Species
name: SLC1A4
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_d33d1795_a100_44fa_b72a_b16fa44c03a9
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4731
name: NDUFV3
constant: false
initial amount: NaN
initial concentration: NaN

metaR PHEt4
reactant: MODEL1310110018#
name: L-phenylalanine transport in via sodium symport
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110018#_4a8341a9_4398_416a_ba95_bf178c92a0b1
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PEMT
is: SBO:0000252
type: Species
is encoded by: hsa:10400
boundary condition: true
constant: false

metaM grdp x
constant: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01285
is: CHEBI:58057
initial amount: NaN
name: geranyl diphosphate(3-)
initial concentration: 1.0
has only substance units: false

metaR r2109
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110018#
reversible: true
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_26dc3143_f38b_47c8_866a_15794df5b54e
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AA278423
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: _AA278423_1_c

http://identifiers.org/biomodels.db/MODEL1310110018#_30cde12b_1fc7_42e6_8eb5_91944996872f
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:171425
name: CLYBL
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_46abef1c_c36d_4b2c_b925_0963428ca77f
name: SLC22A2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6582
has only substance units: false

metaM sebcoa x
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: sebacoylcoa
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_b3610ea1_899d_4a5a_83f7_abbe82b6868e
type: Species
is encoded by: hsa:8396
is: SBO:0000252
initial amount: NaN
is: P78356
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: PIP4K2B

metaR r2526
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reversible: true
is: SBO:0000185

metaM CE5119 m
is: SBO:0000247
type: Species
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
boundary condition: false
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
initial amount: NaN
initial concentration: 1.0

metaM hspg l
name: heparan sulfate proteoglycan
is: HMDB01993
constant: false
is: SBO:0000247
is: CHEBI:17899
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

metaR CHSTEROLt1
name: cholesterol intracellular transport
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reactant: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_e8b505b0_d684_4630_a7fa_063dac6c4f05
has only substance units: false
is: Q9GZS9
is: SBO:0000252
name: CHST5
is encoded by: hsa:23563
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaM adrnl c
has only substance units: false
is: HMDB00068
is: SBO:0000247
initial amount: NaN
is: CHEBI:33568
type: Species
boundary condition: false
name: Adrenaline
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
constant: false
initial concentration: 1.0

metaR DADAe
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.4
kinetic law: MODEL1310110018#
name: Deoxyadenosine deaminase, extracellular
product: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
fast: false

metaM docohexcoa m
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: 2,4,7,10,13,16-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR GUACYC
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/4.6.1.2
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
name: guanylate cyclase
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
reactant: MODEL1310110018#

metaR AICARte
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_2e24094a_8842_4423_bf11_385a48a49c44
initial concentration: NaN
has only substance units: false
is: P27815
is: SBO:0000252
is encoded by: hsa:5141
name: PDE4A
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR ALCD21 D
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.99.24
name: alcohol dehydrogenase (D-1,2-propanediol)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_00f64f17_1676_4b37_841e_3e2fea5f8b39
constant: false
name: NME2
initial concentration: NaN
is: P22392
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4831
has only substance units: false
type: Species
initial amount: NaN

metaR ADPT
is: SBO:0000176
name: adenine phosphoribosyltransferase
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.7
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
reversible: false
type: Reaction

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM xylu L c
type: Species
is: HMDB00751
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17399
initial concentration: 1.0
name: L-xylulose

metaR r2525
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_b30cdbae_6efd_467f_8cb7_671f0276af98
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ABCB4
is: SBO:0000252
boundary condition: true
is: A4D1D5
type: Species
is encoded by: hsa:5244
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_1ab77893_d691_4ec8_8883_b00090bd0f69
initial concentration: NaN
has only substance units: false
is: P78542
constant: false
initial amount: NaN
name: HK1
is encoded by: hsa:3098
boundary condition: true
is: SBO:0000252
type: Species

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_975bbd87_42ed_4755_85e6_47d8ce50cb21
is: SBO:0000252
is encoded by: hsa:1375
constant: false
is: B7Z5T8
name: CPT1B
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM glc D c
boundary condition: false
is: CHEBI:4167
is: SBO:0000247
has only substance units: false
name: D-glucose
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_45c9253d_ed1e_4d42_8ddd_ae49413d03fb
is: SBO:0000252
initial amount: NaN
is: P42336
initial concentration: NaN
is encoded by: hsa:5290
constant: false
type: Species
boundary condition: true
has only substance units: false
name: PIK3CA

http://identifiers.org/biomodels.db/MODEL1310110018#_6a98de07_a738_49bc_adab_e38b8bf33d04
is encoded by: hsa:4245
initial amount: NaN
name: MGAT1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: P26572
initial concentration: NaN

metaR DOLPMT2 Uer
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110018#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
reactant: MODEL1310110018#

metaR HEX7
fast: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000304
name: hexokinase (D-fructose:ATP)

http://identifiers.org/biomodels.db/MODEL1310110018#_a398563c_8d30_4630_93fa_45a377d10e8d
type: Species
initial concentration: NaN
has only substance units: false
is: Q86VU5
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: COMTD1
is encoded by: hsa:118881
constant: false

metaR CHSTEROLt3
name: cholesterol intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110018#
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
fast: false

metaR TETTET6t
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110018#
reversible: true

metaR GALASE1ly
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
product: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false

metaR RETt
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Retinol transport via faciliated diffusion
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110018#_e1e1c75f_dbed_458e_9420_02a89bf92c65
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: DGKG
is: P49619
is encoded by: hsa:1608
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_7d17b001_55b8_48fc_ac9d_9931c54cee72
has only substance units: false
is encoded by: hsa:23305
is: B2RB13
type: Species
is: SBO:0000252
name: ACSL6
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR RETFA
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000000
name: retinol acyltransferase
type: Reaction

metaR UDPGLCter
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
reactant: MODEL1310110018#
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000

metaM gly e
constant: false
is: CHEBI:3339
type: Species
name: Glycine
initial amount: NaN
is: SBO:0000247
is: C00037
is: HMDB00123
boundary condition: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
initial concentration: 1.0

metaR CHSTEROLt2
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#
fast: false
reversible: true
type: Reaction
name: cholesterol intracellular transport
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0512
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM 5htrp c
is: SBO:0000247
is: CHEBI:17780
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false
initial concentration: 1.0
name: 5-hydroxy-L-tryptophan
is: HMDB00472
type: Species

metaM 2obut c
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
is: SBO:0000247
is: C00109
initial concentration: 1.0
is: HMDB00005
initial amount: NaN
boundary condition: false
has only substance units: false
name: 2-Oxobutanoate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7397fc55_bfbf_4290_a8f1_e16d525babeb
is encoded by: hsa:1375
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: E9PCP2
name: CPT1B
initial concentration: NaN
constant: false
type: Species

metaR r0191
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_cb6d71e8_7edf_4d4d_8eac_24ad58e38f76
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI480132
type: Species
name: _AI480132_1_c
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_7a2fefa3_aff7_436c_b90a_45dabe8fff8d
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: _AI971036_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_c5279ce8_9684_4e9a_8998_043268d4dbce
is encoded by: hsa:5498
is: SBO:0000252
initial concentration: NaN
constant: false
is: P50336
boundary condition: true
has only substance units: false
initial amount: NaN
name: PPOX
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_cb1dfaf4_9c81_4cdf_9e29_5ae915620fda
type: Species
is: Q02221
constant: false
initial concentration: NaN
name: COX6A2
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1339

metaM dgchol x
is: SBO:0000247
is: CHEBI:36252
type: Species
name: glycochenodeoxycholate
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
is: HMDB00637

http://identifiers.org/biomodels.db/MODEL1310110018#_90c03ae6_6f29_4b76_a0eb_8bad95300db4
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
initial concentration: NaN
has part: B3KT19
is encoded by: hsa:5291
type: Species
constant: false
has part: B4DER4
boundary condition: true

metaR DGAT
kinetic law: MODEL1310110018#
name: diacylglycerol acyltransferase
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.20
reactant: MODEL1310110018#

metaR COAtg
name: CoA transport in Golgi via diffusion
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false

metaM ksi deg35 l
initial amount: NaN
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
constant: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 35
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00143

metaM idp c
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03335
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
name: IDP(3-)
is: CHEBI:58280
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_21bee1fd_9fbc_4074_b75b_20aea2050d9c
constant: false
is: P24752
name: ACAT1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR r1318
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110018#

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM asn L e
type: Species
is: HMDB00168
is: CHEBI:17196
is: SBO:0000247
initial concentration: 1.0
name: L-asparagine
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR BACCL
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false
reactant: MODEL1310110018#
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_4d2c16b1_0699_402c_bbd4_3b6c45cff852
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9UBM7
name: DHCR7
initial amount: NaN
has only substance units: false
is encoded by: hsa:1717

metaR DCSPTN1COAtx
reversible: true
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_f07281d3_ce0b_40e2_9ca1_6014ea18f011
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:T83654
name: _T83654_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_c3b4e117_99cd_4dc0_a329_384f1b09b985
initial amount: NaN
is encoded by: hsa:79717
constant: false
boundary condition: true
has only substance units: false
name: PPCS
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9HAB8

metaR AMANK
type: Reaction
name: N-acetyl-D-mannosamine kinase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
is version of: http://identifiers.org/ec-code/2.7.1.59
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000176

metaM hexc c
initial amount: NaN
initial concentration: 1.0
is: HMDB02356
type: Species
is: CHEBI:31013
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
has only substance units: false
name: cerotate
constant: false
boundary condition: false
is: SBO:0000247

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57767
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ca4b76ae_c915_405f_97c8_2224e33c2890
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: O76062
is encoded by: hsa:7108
name: TM7SF2
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_c5905dcd_711e_4734_9e4a_c13645b6982c
initial amount: NaN
has only substance units: false
name: SLC5A7
type: Species
is encoded by: hsa:60482
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9GZV3
boundary condition: true

metaM xol7aone c
is: CHEBI:17899
is: HMDB01993
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_44e0a4f5_7e9b_4198_8049_5876625a4c5d
is: O43505
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: B3GNT1
is encoded by: hsa:11041
initial amount: NaN

metaM idp e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB03335
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
initial amount: NaN
boundary condition: false
type: Species
name: IDP(3-)

metaM 6a2ohxnt x
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17534
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
boundary condition: false

metaM co2 x
type: Species
name: carbon dioxide
is: HMDB01967
boundary condition: false
is: CHEBI:16526
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN

metaM 5HPET c
type: Species
name: 5(S)-HPETE(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57450
is: HMDB01193
boundary condition: false
constant: false

metaR ACNAM9PL
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110018#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.5.1.56
fast: false
product: MODEL1310110018#
type: Reaction
is: SBO:0000176

metaM glyald c
is: SBO:0000247
has only substance units: false
is: C00577
type: Species
is: CHEBI:17378
name: D-Glyceraldehyde
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d764d2d7_4e8a_4cb1_9885_487745c633b7
type: Species
is encoded by: hsa:219
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH1B1
is: P30837
boundary condition: true
initial concentration: NaN
constant: false

metaM hs deg6 l
initial amount: NaN
name: heparan sulfate, degradation product 6
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: HMDB01352
constant: false
is: CHEBI:17180
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM asn L c
type: Species
name: L-asparagine
has only substance units: false
initial concentration: 1.0
is: HMDB00168
is: CHEBI:17196
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
initial amount: NaN

metaR DOCO13EFATP
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR LTA4H
modifier: MODEL1310110018#
name: Leukotriene A-4 hydrolase
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.3.2.6
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000134
reactant: MODEL1310110018#

metaM eaflatoxin e
is: HMDB06558
initial concentration: 1.0
name: aflatoxin B1 exo-8,9-epoxide
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
initial amount: NaN
is: CHEBI:30725
is: SBO:0000247

metaM dmnoncoa x
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB11604

metaM hs deg2 l
is: SBO:0000247
is: HMDB01352
boundary condition: false
is: CHEBI:17180
has only substance units: false
initial concentration: 1.0
name: heparan sulfate, degradation product 2
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11

metaM ksi deg34 l
name: keratan sulfate I, degradation product 34
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
has only substance units: false
is: HMDB00812
constant: false
is: CHEBI:16953
initial concentration: 1.0
boundary condition: false
type: Species

metaM hs deg11 l
is: HMDB00868
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
name: heparan sulfate, degradation product 11
constant: false
is: CHEBI:57737
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM hexc e
initial concentration: 1.0
constant: false
is: CHEBI:31013
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: cerotate
initial amount: NaN
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: HMDB02356

http://identifiers.org/biomodels.db/MODEL1310110018#_433b7ca6_4921_4b51_b28f_29ea0114702d
initial concentration: NaN
is encoded by: hsa:221
has only substance units: false
initial amount: NaN
is: P43353
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH3B1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_d9b0b208_29ce_48f7_bb4e_ac9f97e42e0f
initial amount: NaN
initial concentration: NaN
name: ALDH1A3
boundary condition: true
type: Species
constant: false
is: P47895
is: SBO:0000252
has only substance units: false
is encoded by: hsa:220

metaM CE5786 e
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
is: HMDB02710
constant: false
name: kinetensin
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:27485

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110018#
reversible: true
fast: false
product: MODEL1310110018#
type: Reaction
name: bilirubin transport via bicarbonate countertransport
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaM biliverd c
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: biliverdin(2-)
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: HMDB01008
is: CHEBI:57991
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_31375ae2_2f6f_40e1_b267_e02da7c05780
name: FADS2
is: O95864
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9415
boundary condition: true

metaM mpdol U c
type: Species
initial amount: NaN
is: CHEBI:18396
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaM ksi pre2 g
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:2504
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 2
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: HMDB06552
initial concentration: 1.0
has only substance units: false

metaM fe3 e
has only substance units: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: HMDB12943
is: CHEBI:29034
type: Species
initial amount: NaN
constant: false
name: Fe3+
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM tcynt e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: thiocyanate
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
initial amount: NaN
is: CHEBI:18022

http://identifiers.org/biomodels.db/MODEL1310110018#_d1fd39a5_c48b_4611_8b65_74681ebd9078
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10840
name: ALDH1L1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: O75891

metaR FAOXC81C61m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR FUCtly
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
name: L-fucose efflux from lysosome
fast: false
is described by: ECO:0000000

metaR BILDGLCURt
modifier: MODEL1310110018#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_32ec819e_8b49_437e_a1ad_53c8c2220e77
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5152
constant: false
type: Species
has only substance units: false
boundary condition: true
name: PDE9A

metaM HC00229 e
initial amount: NaN
name: Isomaltose
is: CHEBI:28189
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_6bb2052f_4dd1_48f6_9066_3c5fa60cd082
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: SLC25A16
is: P16260
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8034
has only substance units: false

metaR INSTt2r
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110018#
fast: false
name: inositol transport in via proton symport
product: MODEL1310110018#
type: Reaction
reversible: true

metaR ANTHte
is described by: ECO:0000134
reversible: true
fast: false
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: Transport of anthranilate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR CYTK13n
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is: SBO:0000176
reversible: true
name: cytidylate kinase (dCMP,dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM HC01434 m
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: oxalatosuccinate(3-)
initial concentration: 1.0
is: CHEBI:58931
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

metaM ksi pre13 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:2504
is: HMDB06552
is: SBO:0000247

metaR HXPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110018#
is described by: ECO:0000269
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_18f23a5e_29cc_46e4_96d0_dc352b2e4530
has only substance units: false
initial amount: NaN
name: SDHD
boundary condition: true
is: O14521
initial concentration: NaN
type: Species
is encoded by: hsa:6392
constant: false
is: SBO:0000252

metaM cdp m
constant: false
is: CHEBI:58069
name: CDP(3-)
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
is: HMDB01546
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaM ksii core4 pre1 g
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 1
constant: false

metaR S3TASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_6190e636_1544_436c_9a14_1b82405938a9
has only substance units: false
is: O94777
is encoded by: hsa:8818
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DPM2

metaR PGSr
is: SBO:0000176
fast: false
name: Prostaglandin G/H synthase
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.99.1
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR LPCOXp
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
name: L-pipecolate oxidase, peroxisomal
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
reversible: false
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.3.1
is: SBO:0000176
fast: false

metaM fe3 c
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 3
name: Fe3+
initial concentration: 1.0
is: HMDB12943
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_24a24cf3_1773_4bcd_9d18_f3e0d3493e70
is: A6NN98
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: MTMR2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8898

metaR B3GALT3g
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.79
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
product: MODEL1310110018#
name: Beta-1,3-galactosyltransferase 3

metaR NAGLCAly
name: N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#

metaM cdp n
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58069
type: Species
is: HMDB01546
is: SBO:0000247
constant: false
name: CDP(3-)
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

http://identifiers.org/biomodels.db/MODEL1310110018#_4595a886_eab1_44e1_a5b0_625c58d670b4
is: Q59EH3
initial amount: NaN
is encoded by: hsa:52
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ACP1
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3537c431_1d13_445e_b09a_0ab6bfafd3d3
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8706
is: SBO:0000252
type: Species
constant: false
is: B3KTQ4
name: B3GALNT1

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is: SBO:0000176
reactant: MODEL1310110018#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110018#

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
is: SBO:0000247
is: CHEBI:57462
type: Species
constant: false
is: HMDB02200
initial concentration: 1.0
name: leukotriene E4(1-)
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_01c478e8_69b9_4cf9_b590_e7c9983bff0f
is encoded by: hsa:22934
initial amount: NaN
constant: false
initial concentration: NaN
name: RPIA
is: SBO:0000252
has only substance units: false
is: P49247
boundary condition: true
type: Species

metaR MI134P4P
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
name: inositol-1,3,4-trisphosphate 4-phosphatase
is: SBO:0000176
product: MODEL1310110018#

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110018#
name: beta-glucuronidase, lysosomal
type: Reaction

metaM paps c
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
is: CHEBI:58339
constant: false
initial concentration: 1.0
initial amount: NaN
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
has only substance units: false
is: SBO:0000247

metaM mepi e
name: Metanephrine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H16NO3 CHARGE: 1 INCHI: InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3 EHMN_ABBREVIATION: C05588
is: CHEBI:144365
is: SBO:0000247
type: Species
is: HMDB04063

metaR 3AIBTm
is described by: ECO:0000304
name: L-3-aminoisobutyrate transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: true

metaR ALADGLNexR
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000304
fast: false
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110018#

metaR FAOXC14C12x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR r1646
type: Reaction
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
modifier: MODEL1310110018#
reversible: true
is described by: ECO:0000000

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM uri e
is: CHEBI:16704
boundary condition: false
type: Species
has only substance units: false
is: HMDB00296
initial amount: NaN
is: C00299
is: SBO:0000247
name: Uridine
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false

metaR UGCG
reversible: false
name: Ceramide glucosyltransferase
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
name: beta-galactosidase, lysosomal
reactant: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110018#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_1edfc17e_d289_4ad4_80ee_4275a57fcda3
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: Q16134
name: ETFDH
is encoded by: hsa:2110
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR DOLGPP Uer
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction

metaR HSAT1ly
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110018#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR GLYCTDle
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110018#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110018#
is described by: ECO:0000134

metaR CHOLD2m
is: SBO:0000176
name: choline dehydrogenase (FAD acceptor), mitochondrial
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.99.1
reversible: false
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
fast: false
product: MODEL1310110018#

metaM co2 r
is: C00011
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16526
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
is: HMDB01967
type: Species
is: SBO:0000247
initial amount: NaN

metaR 41R2A1H12BOOX
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110018#
fast: false
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
reversible: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
is described by: ECO:0000269
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR URATEt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
product: MODEL1310110018#
name: urate export from cytosol
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#

MODEL1310110018#
species: metaM HC02175 e
species: metaM 5mthf c
species: metaM cs e l
species: metaM mal L c
species: metaM h m
species: metaM glu L c
species: metaM idp n
species: metaM xyl D l
species: metaM ump g
species: metaM gly c
species: metaM HC01231 m
species: metaM pail3p hs c
species: metaM n2m2nm l
species: metaM orn m
species: metaM dolmanp U c
species: metaM 7dhf e
species: metaM gal1p c
species: metaM pacald c
species: metaM eicostet c
species: metaM ade e
stoichiometry: 0.013183
species: metaM idp c
species: metaM pmtcrn m
species: metaM hexccoa x
species: metaM ksi pre23 g
species: metaM imp e
species: metaM 25aics c
species: metaM thcholstoic c
species: metaM trdox m
species: metaM dad 2 c
species: metaM ksii core4 deg1 l
species: metaM leu L e
species: metaM lac D e
species: metaM coa n
species: metaM urate c
species: metaM retinal 11 cis c
species: metaM leuktrC4 e
stoichiometry: 4.0
species: metaM 34dhphe c
species: metaM coa c
species: metaM oxa m
species: metaM dtdp n
species: metaM nadp x
species: metaM galgluside hs c
species: metaM Ser Thr l
species: metaM ksii core2 pre6 g
species: metaM cholp g
species: metaM ksi deg1 e
species: metaM prostge1 c
species: metaM tststerone e
species: metaM hom L e
species: metaM cyan c
species: metaM ksii core4 e
species: metaM acnamp c
species: metaM sphmyln hs g
species: metaM 3mob m
species: metaM lnlccrn c
species: metaM chito2pdol U c
species: metaM ddcacoa m
species: metaM HC01672 c
species: metaM glyc R m
species: metaM od2coa c
species: metaM hs deg25 l
species: metaM gar c
species: metaM o2s x
species: metaM dhlam m
species: metaM ipdp c
species: metaM eitetcoa m
stoichiometry: 0.505626
species: metaM gd3 hs g
species: metaM pail hs n
species: metaM ksi deg38 l
species: metaM HC00591 c
species: metaM ksi deg1 l
species: metaM CE1943 e
species: metaM xol7ah2 c
species: metaM prostgi2 r
species: metaM ha pre1 l
species: metaM ksii core2 pre1 g
species: metaM pristcoa x

metaM frdp x
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: farnesyl pyrophosphate(3-)
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:175763
constant: false
boundary condition: false
is: HMDB00961
initial concentration: 1.0

metaR r1647
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000

metaR HCOUMARINte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reversible: true
fast: false
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
name: xenobiotic transport
reactant: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_f6ee3b9b_5353_4677_a44e_16cb2c350406
name: NME1:NME2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:4830

metaM glyald m
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
initial concentration: 1.0
name: D-glyceraldehyde
type: Species
is: HMDB01051
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
reactant: MODEL1310110018#

metaR FAOXC2442246x
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM HC02204 e
initial amount: NaN
name: prostaglandin-b1
is: CHEBI:27624
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

metaR r0119
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#

metaM coumarin c
is: HMDB01218
initial amount: NaN
initial concentration: 1.0
constant: false
name: coumarin
is: CHEBI:28794
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
boundary condition: false
type: Species

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
boundary condition: false
is: SBO:0000247
is: HMDB00058
constant: false
type: Species
has only substance units: false
is: CHEBI:58165
name: 3',5'-cyclic AMP(1-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_0bfcb3a3_c3d5_45ac_864a_2ad84cb77937
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: DPAGT1
constant: false
is encoded by: hsa:1798

http://identifiers.org/biomodels.db/MODEL1310110018#_8f6e5833_49dd_4093_8d62_4537f8b95650
constant: false
initial concentration: NaN
is encoded by: hsa:5831
name: PYCR1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P32322

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c60a071c_ce08_4598_b10c_c60cadd0dea7
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: ST3GAL3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3716b0bf_6b8b_4e24_85e9_3ba8429d2890
initial concentration: NaN
has only substance units: false
name: _BF195998_1_x
is: SBO:0000252
is encoded by: hsa:BF195998
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR r0425
kinetic law: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reversible: true
fast: false
name: EC:1.1.1.42
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110018#
type: Reaction

metaM lneldc c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: linoelaidic acid (all trans C18:2)
is: HMDB06270
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
boundary condition: false

metaR r1648
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110018#

metaM c6dc c
constant: false
is: SBO:0000247
is: C14143
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB04047
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: adipoyl carnitine

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM xtsn c
is: HMDB00299
is: CHEBI:18107
is: SBO:0000247
initial concentration: 1.0
name: xanthosine
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_97632091_ed42_4aab_b2f5_59c363182665
is encoded by: hsa:10423
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: CDIPT
is: O14735
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM tcynt c
has only substance units: false
is: SBO:0000247
name: thiocyanate
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:18022
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_28188a59_2cda_4765_bfb3_364f179e4642
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SCD
is encoded by: hsa:6319
has only substance units: false
type: Species
is: O00767

http://identifiers.org/biomodels.db/MODEL1310110018#_25a4c36f_807d_4191_88be_fd53a17df006
has only substance units: false
is: Q6IBA0
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4725
boundary condition: true
initial concentration: NaN
name: NDUFS5

metaR NACHEXA21ly
product: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000

metaR HDCEAtr
is: SBO:0000185
product: MODEL1310110018#
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

metaR r0424
modifier: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

metaM lnlccrn m
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
boundary condition: false

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
product: MODEL1310110018#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: RE1518

metaR PRISTCOAtcx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM 3dodtricoa m
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05280
is: SBO:0000247
boundary condition: false
is: HMDB03952
has only substance units: false
initial amount: NaN
constant: false
name: 3,6,9-dodecatrienoylcoa
type: Species

metaM HC02204 c
name: prostaglandin-b1
has only substance units: false
initial amount: NaN
is: CHEBI:27624
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
boundary condition: false
is: SBO:0000247

metaM galside hs c
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
initial concentration: 1.0
type: Species

metaR FAOXC226C227m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaM paps g
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
is: HMDB01134
boundary condition: false
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM ametam c
is: SBO:0000247
is: CHEBI:57443
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
name: S-Adenosylmethioninamine
type: Species
is: C01137
is: HMDB00988
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_8c7b30ff_785b_4c10_822d_30221626bf5c
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: P07954
initial amount: NaN
name: FH
is encoded by: hsa:2271
is: SBO:0000252
constant: false

metaM 56dura c
name: 5,6-dihydrouracil
is: HMDB00076
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
type: Species
constant: false
has only substance units: false
is: CHEBI:15901

metaR r1649
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaR TREHe
reversible: false
is: SBO:0000176
name: alpha,alpha-trehalase
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.28
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR

metaM fald c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16842
name: formaldehyde
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
is: HMDB01426
type: Species
is: SBO:0000247

metaM uri c
initial concentration: 1.0
is: CHEBI:16704
is: C00299
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
is: HMDB00296
boundary condition: false
name: Uridine
is: SBO:0000247

metaR ACCOAtn
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110018#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000

metaR S2L2N2M2MASNtly
reactant: MODEL1310110018#
name: s2l2n2m2masn transport, extracellular to lysosome
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaM lneldc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial amount: NaN
is: SBO:0000247
name: linoelaidic acid (all trans C18:2)
type: Species
is: HMDB06270
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR XOL7AH2tm
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110018#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110018#
reversible: true

metaM k e
is: HMDB00586
type: Species
is: CHEBI:29103
initial amount: NaN
name: potassium
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00238

metaR SUCOAS1m
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
kinetic law: MODEL1310110018#
name: Succinate--CoA ligase (GDP-forming)
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#

metaM cmp n
constant: false
name: CMP(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaR NH4tp
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
name: ammonia peroxisomal transport

metaM ksi deg3 l
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00573
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
name: keratan sulfate I, degradation product 3
is: SBO:0000247
is: CHEBI:30825

metaM CE5162 r
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial concentration: 1.0
is: CHEBI:57923
name: trans,cis-2,9-octadecadienoyl-CoA
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaM bilglcur e
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
is: CHEBI:57767
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_662dfb6b_60c9_43e1_92b3_5e4b92924bd0
has only substance units: false
constant: false
is encoded by: hsa:5146
boundary condition: true
is: P51160
name: PDE6C
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

metaR r0002
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Active transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_fbac462d_768b_4009_a480_1b3d9a922782
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4729
type: Species
name: NDUFV2
constant: false
is: P19404

metaR HESTRATRIOLte
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
type: Reaction
name: hydroxylated estrogen derivative transport
reversible: true
is: SBO:0000185

metaM 5oxpro e
name: 5-oxoprolinate
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00267
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
type: Species
is: CHEBI:57606

metaR BTNDm
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.1.12
name: biotinidase (biotin), mitochondrial
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reversible: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_c6f4f2a5_f679_42b9_9d5c_94d0772d7fa5
is encoded by: hsa:4830
initial concentration: NaN
initial amount: NaN
constant: false
is: P15531
is: SBO:0000252
name: NME1
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_0afc20f0_d1df_44e4_83e0_e03f05c8d3b3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3028
constant: false
boundary condition: true
name: HSD17B10
type: Species
initial amount: NaN
has only substance units: false
is: Q99714

metaM k c
constant: false
name: potassium
boundary condition: false
is: CHEBI:29103
initial amount: NaN
type: Species
has only substance units: false
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
is: HMDB00586
is: SBO:0000247

metaR UMPK
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaM doldp U r
is: SBO:0000247
name: Dolichol diphosphate, human uterine homolog
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
type: Species
is: CHEBI:15750
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_3f42071c_a411_4988_aa05_657b0d7d9e71
is: SBO:0000252
constant: false
is encoded by: hsa:4882
initial amount: NaN
is: P20594
initial concentration: NaN
name: NPR2
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_cfb17b22_8a0d_4c51_beaa_133be694c669
initial amount: NaN
name: LEFTY1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:10637
is: O75610
has only substance units: false

metaM cholp g
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:295975
is: C00588
name: choline phosphate(1-)
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_714d4150_4255_404c_997b_9d9e709a0228
boundary condition: true
initial amount: NaN
is: Q6FG42
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4701
has only substance units: false
name: NDUFA7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_4f77a3c0_2544_4a50_8f74_82864e513654
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2983
has only substance units: false
constant: false
type: Species
name: GUCY1B3
boundary condition: true
is: SBO:0000252
is: Q02153

http://identifiers.org/biomodels.db/MODEL1310110018#_41f966dd_96dd_4f28_9000_6c06e2474eac
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:157506
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8IZV5
name: RDH10

http://identifiers.org/biomodels.db/MODEL1310110018#_e3e78706_8716_4af8_bf46_2cbee458d511
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: _AI640625_1_c
is encoded by: hsa:AI640625

http://identifiers.org/biomodels.db/MODEL1310110018#_dc9fac81_75d0_4cb8_ba18_79b24963e5fc
is encoded by: hsa:622
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: BDH1
is: SBO:0000252
boundary condition: true

metaM bilglcur c
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57767
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR GPIAT
reactant: MODEL1310110018#
type: Reaction
name: glucosaminylphosphatidyl inositol acetyltransferase
fast: false
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269

metaM ahdt e
initial amount: NaN
initial concentration: 1.0
is: HMDB00980
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
is: CHEBI:58462
name: 7,8-dihydroneopterin 3'-triphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110018#_84a5e68c_a3e8_47f4_8859_58b1fd2e2dce
initial concentration: NaN
is encoded by: hsa:1557
is: P33261
name: CYP2C19
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR NH4tn
type: Reaction
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
name: ammonia nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_37e2e035_a246_4dee_aa21_73a6c59e3541
initial concentration: NaN
type: Species
is: SBO:0000252
name: NDUFA4
has only substance units: false
initial amount: NaN
boundary condition: true
is: O00483
constant: false
is encoded by: hsa:4697

http://identifiers.org/biomodels.db/MODEL1310110018#_bc90ee2f_e900_4898_a324_af74346dfc5c
constant: false
boundary condition: true
is encoded by: hsa:91734
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9BXS1
name: IDI2
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_1a4a84b9_7f8e_4de8_b062_cd55637b3098
initial amount: NaN
is encoded by: hsa:130367
initial concentration: NaN
has only substance units: false
is: Q8IWX5
type: Species
name: SGPP2
boundary condition: true
constant: false
is: SBO:0000252

metaM 5oxpro c
is: SBO:0000247
is: HMDB00267
type: Species
constant: false
name: 5-oxoprolinate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: CHEBI:57606
initial amount: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r2065
modifier: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM Ser Gly Ala X Gly l
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB02183
boundary condition: false
initial concentration: 1.0
is: CHEBI:36005
initial amount: NaN

metaR ATPtx
reversible: true
product: MODEL1310110018#
name: ATP transporter, peroxisomal
kinetic law: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110018#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR G12MT2 U
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reversible: false
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_ddbf3d3e_dd14_4e8c_bb7b_ecf59812f1ee
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NME7
is: Q9Y5B8
constant: false
type: Species
is encoded by: hsa:29922
boundary condition: true

metaM cmp m
is: CHEBI:60377
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
constant: false
has only substance units: false
name: CMP(2-)
initial concentration: 1.0

metaM co2 m
is: SBO:0000247
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: C00011
name: CO2
initial concentration: 1.0
is: HMDB01967

metaR FTHFL
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: Formate-tetrahydrofolate ligase
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_172c712b_94bd_4fbc_bc21_6981f9c744b8
type: Species
is encoded by: hsa:622
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: BDH1
is: Q02338
has only substance units: false
initial concentration: NaN

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaR r0999
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Facilitated diffusion
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110018#

metaR ACONT
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
name: aconitase
kinetic law: MODEL1310110018#
is described by: ECO:0000134

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM CE1940 e
is: SBO:0000247
initial amount: NaN
is: CHEBI:30623
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: spermidine monoaldehyde 2
constant: false
is: HMDB02329
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940

metaR KSII CORE4t
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110018#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000185

metaR r2382
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e336e3f6_bf0c_4e9f_8025_e85c9fff26d4
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q59GJ6
name: MTHFR
boundary condition: true
is encoded by: hsa:4524
initial concentration: NaN
constant: false
type: Species

metaR r1651
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
reversible: true

metaM cortsn r
is: SBO:0000247
constant: false
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
is: CHEBI:16962
initial concentration: 1.0
is: HMDB02802
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: cortisone

metaR GALASE9ly
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110018#_20654d0d_1377_403a_a6e4_4ba5dd955e16
is: P05091
boundary condition: true
has only substance units: false
constant: false
name: ALDH2
type: Species
is: SBO:0000252
is encoded by: hsa:217
initial amount: NaN
initial concentration: NaN

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58332
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
initial concentration: 1.0

metaR r2380
reactant: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110018#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_13f9e671_162a_44e5_8023_eea0a160817e
type: Species
is encoded by: hsa:5143
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q7KYS4
is: SBO:0000252
constant: false
initial amount: NaN
name: PDE4C

metaR RE1796R
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
name: RE1796
fast: false
reactant: MODEL1310110018#
type: Reaction

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM galside hs l
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:12947
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_68fce00e_d724_491a_874d_e1b5f41b7fdb
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ST6GAL1
is encoded by: hsa:6480
initial concentration: NaN
type: Species
boundary condition: true

metaR CYANt
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#
name: Cyanide transport via diffusion (extracellular to cytosol)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction

metaR r1650
is: SBO:0000185
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR N3Tg
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.122
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is described by: ECO:0000000

metaM HC01399 m
is: CHEBI:27466
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM xol7aone r
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB01993
initial concentration: 1.0
constant: false
is: CHEBI:17899

metaR r1653
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#

metaR ATPH1e
name: ATP diphosphohydrolase
reactant: MODEL1310110018#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_e91b6246_f66e_436c_a264_7f9f6fab6fce
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9NSW9
type: Species
name: SLC9A5
is encoded by: hsa:6553
initial concentration: NaN
initial amount: NaN
constant: false

metaR GLCAASE1ly
product: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_8f07fdb1_fa47_49c3_a2a3_56f46286d627
initial amount: NaN
is: P16152
name: CBR1
initial concentration: NaN
is encoded by: hsa:873
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaR r0998
name: Facilitated diffusion
kinetic law: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110018#
is: SBO:0000185
fast: false

metaR PRAGSr
is version of: http://identifiers.org/ec-code/2.1.2.2
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: phosphoribosylglycinamide synthase
is described by: ECO:0000269
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_76e827f7_1526_411d_8240_17e72317a3ac
initial concentration: NaN
type: Species
has only substance units: false
name: DPM1
is: O60762
boundary condition: true
is encoded by: hsa:8813
constant: false
initial amount: NaN
is: SBO:0000252

metaM lnlccrn c
type: Species
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06469
name: Linoleyl carnitine
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_cd819e1e_35c0_4d93_b2b5_eaa192c3f227
constant: false
initial amount: NaN
initial concentration: NaN
name: PKLR
has only substance units: false
is: P30613
boundary condition: true
type: Species
is encoded by: hsa:5313
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_3ec6c096_52b5_41ab_af7f_da43c4bfae7f
is: SBO:0000252
boundary condition: true
type: Species
name: PIGP
has only substance units: false
is encoded by: hsa:51227
initial amount: NaN
initial concentration: NaN
constant: false

metaR r1652
modifier: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cmp g
is: HMDB00095
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: CMP(2-)
is: CHEBI:60377
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247

metaM galgluside hs g
has only substance units: false
is: CHEBI:58223
is: SBO:0000247
boundary condition: false
is: HMDB00295
is: C00015
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
name: galactosyl glucosyl ceramide

http://identifiers.org/biomodels.db/MODEL1310110018#_529f73f3_24b6_456e_be3d_2675e706ebd4
type: Species
is: B3KT86
initial amount: NaN
is encoded by: hsa:109
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: ADCY3

metaM cholp c
is: SBO:0000247
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
boundary condition: false
is: CHEBI:295975
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: choline phosphate(1-)

metaR RE3269C
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
fast: false
name: RE3269
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.3.48
is: SBO:0000176

metaM lnlc r
type: Species
has only substance units: false
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: SBO:0000247
is: HMDB00673
is: CHEBI:30245
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: linoleate

metaM gdp g
is: HMDB01201
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
is: SBO:0000247
name: GDP(3-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:58189
type: Species

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR GLCURtly
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
product: MODEL1310110018#

metaR LALDO2x
type: Reaction
reversible: false
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF

metaR PSSA1 hs
product: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
modifier: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
name: Phosphatidylserine synthase homo sapiens
reversible: true
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
type: Reaction
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a6164b55_0eb5_4b03_930b_87998e7258b3
is: E5KNH5
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:4723
name: NDUFV1
has only substance units: false

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
name: Transport of (R)-Pantothenate
reversible: true

metaR r1655
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_9a648d0c_fa36_4c5b_9e71_e1dce6af0de0
type: Species
name: _AI769281_1_e
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI769281
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR r0434
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
modifier: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaR KCC2t
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is described by: ECO:0000269

metaR RE1796M
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: true
type: Reaction
name: RE1796
is: SBO:0000176
reactant: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.145

http://identifiers.org/biomodels.db/MODEL1310110018#_a57e1f57_9ee7_448b_803b_655eccdae0a2
boundary condition: true
constant: false
is encoded by: hsa:51181
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DCXR
type: Species
is: Q7Z4W1
has only substance units: false

metaM biocyt e
initial amount: NaN
initial concentration: 1.0
is: C05552
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
has only substance units: false
is: HMDB03134
name: Biocytin
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
constant: false

metaR MCLOR
kinetic law: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
reactant: MODEL1310110018#
is: SBO:0000176
name: 3-Mercaptolactate:NAD+ oxidoreductase
type: Reaction
product: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_cc6d1446_623e_4cca_abad_10e425d0e04b
initial concentration: NaN
constant: false
is encoded by: hsa:250
has only substance units: false
boundary condition: true
is: P05187
is: SBO:0000252
initial amount: NaN
name: ALPP
type: Species

metaM ksii core2 deg5 l
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species

metaM debrisoquine e
initial concentration: 1.0
name: debrisoquine
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
boundary condition: false
constant: false
is: HMDB06543
initial amount: NaN
is: CHEBI:34665
is: SBO:0000247
has only substance units: false
type: Species

metaM m7masnB g
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
has only substance units: false
is: C05881
is: SBO:0000247
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)

metaM dmnoncoa c
constant: false
type: Species
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: HMDB11604
initial concentration: 1.0
boundary condition: false

metaR r1654
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_4b8b34ec_8358_4f8d_9992_e1a3f7dca51e
is: SBO:0000297
is encoded by: hsa:4758
has part: P16278
is encoded by: hsa:5476
has part: P34059
has part: P10619
has part: Q99519
has only substance units: false
initial amount: NaN
is encoded by: hsa:2720
constant: false
type: Species
is encoded by: hsa:2588
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN

metaM cmp e
is: HMDB00095
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:60377
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species

metaM co2 e
is: HMDB01967
boundary condition: false
name: CO2
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
is: C00011
type: Species

metaM c6dc e
name: adipoyl carnitine
has only substance units: false
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
initial amount: NaN
is: C14143
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB04047
initial concentration: 1.0

metaR ASPDxt
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
name: D-aspartate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
fast: false
reversible: true

metaM galgluside hs l
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB00143
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
name: galactosyl glucosyl ceramide
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0

metaR CITtam
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
type: Reaction
name: citrate transport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF

metaM gdp e
type: Species
has only substance units: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:58189

metaM acetone m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
is: HMDB01659
name: acetone
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_6ae05f29_4a18_48e1_aab8_21d2a2c81769
name: B4GALT2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is: O60909
initial concentration: NaN
is encoded by: hsa:8704
initial amount: NaN

metaM ksi pre33 g
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: CHEBI:2504
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06552
name: keratan sulfate I biosynthesis, precursor 33
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a7fe01da_5324_4388_9e3a_4a86b330e3e6
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q546Y9
is encoded by: hsa:57379
name: AICDA
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_b1e34e71_b438_4d25_8a96_525975e79e7a
name: ALAD
constant: false
initial amount: NaN
is: Q6ZMU0
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:210
has only substance units: false
initial concentration: NaN

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: CHEBI:16953
is: HMDB00812
boundary condition: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_acd8fbf8_5936_4a23_b7bd_02081ed321fc
is: SBO:0000252
is encoded by: hsa:8394
type: Species
initial amount: NaN
is: Q99755
name: PIP5K1A
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM coumarin e
type: Species
is: SBO:0000247
name: coumarin
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
is: HMDB01218
is: CHEBI:28794
constant: false
has only substance units: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_84402b82_aa40_47b5_b172_1966a1449929
type: Species
is encoded by: hsa:29880
initial amount: NaN
constant: false
has only substance units: false
is: Q9Y673
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ALG5

metaR C6DCe
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of adipoyl carnitine into the extra cellular fluid
type: Reaction

metaR r1657
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM galside hs g
initial amount: NaN
is: CHEBI:12947
boundary condition: false
type: Species
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c7880ca3_e5f4_40cb_b9b1_fb6b692baa8d
name: GALE
has only substance units: false
is: Q14376
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2582
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM biocyt c
constant: false
is: C05552
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: Biocytin
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0

metaR FACOAL246 1
product: MODEL1310110018#
fast: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM pail45p hs m
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
is: CHEBI:28910
constant: false
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
has only substance units: false

metaR PYK
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: pyruvate kinase
modifier: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#

metaM fadh2 x
constant: false
name: FADH2(2-)
boundary condition: false
is: CHEBI:58307
is: SBO:0000247
initial concentration: 1.0
is: HMDB01197
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

metaM xol7aone m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01993
has only substance units: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_bc7879f8_c10e_44cb_9aa7_117c37459c1c
is: SBO:0000252
is: Q9UBF8
boundary condition: true
has only substance units: false
is encoded by: hsa:5298
constant: false
name: PI4KB
initial amount: NaN
initial concentration: NaN
type: Species

metaR r0994
product: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110018#
name: Facilitated diffusion
kinetic law: MODEL1310110018#
type: Reaction

metaR PIter
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
fast: false
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
product: MODEL1310110018#

metaR GLXO1
name: glyoxylate oxidase
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
reversible: false
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_bbf209ce_6a1c_4172_8d4d_7eda3507dc2d
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:2203
name: FBP1
is: Q2TU34
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_9d329b46_7619_4ca8_8893_f40e102f4fd5
constant: false
is: P37268
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2222
is: SBO:0000252
initial concentration: NaN
name: FDFT1

metaM co2 c
name: CO2
boundary condition: false
is: HMDB01967
is: CHEBI:3313
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: C00011
notes: FORMULA: CO2 CHARGE: 0
type: Species

metaM cmp c
is: C00055
is: HMDB00095
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
name: CMP
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377
constant: false
type: Species

metaR r1656
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_5d64ad02_1800_4ebe_ae71_015a49b97a7b
boundary condition: true
constant: false
has only substance units: false
name: RRM2B
is: SBO:0000252
is: Q7LG56
is encoded by: hsa:50484
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ab50b65d_c5e0_4c86_8964_81333b27a41c
has only substance units: false
constant: false
name: ATP1A3
is encoded by: hsa:478
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: B7Z2T0
boundary condition: true

metaR LINKDEG1ly
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110018#
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
reversible: false
reactant: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a2971b96_9058_468d_92e9_b62dbacc69f9
is: P47895
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:220
type: Species
has only substance units: false
name: ALDH1A3
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_a08079b4_9964_4d32_b5ad_fd2ce676a39f
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:23439
is: Q9UN42
initial amount: NaN
name: ATP1B4
has only substance units: false
constant: false
is: SBO:0000252

metaR OIVD1m
is described by: ECO:0000269
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110018#
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is: SBO:0000176
fast: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_4e17a4c3_f8a4_4d9a_af40_4a0d6aca6027
name: PYCRL
type: Species
is: SBO:0000252
boundary condition: true
is: Q53H96
constant: false
initial concentration: NaN
is encoded by: hsa:65263
has only substance units: false
initial amount: NaN

metaM thexddcoa m
is: HMDB02288
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: trans7,10-hexadecadienoylcoa
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
type: Species

metaM naglc2p U c
initial amount: NaN
is: SBO:0000247
is: CHEBI:18278
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
constant: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
boundary condition: false

metaM pail45p hs n
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r2389
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110018#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR HOXG
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.99.3
modifier: MODEL1310110018#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
kinetic law: MODEL1310110018#
name: Heme oxygenase 1
fast: false
is: SBO:0000176
product: MODEL1310110018#
is described by: ECO:0000134

metaR HESTRATRIOLtr
fast: false
type: Reaction
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
product: MODEL1310110018#
name: hydroxylated estrogen derivative transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_bbcaa95c_9856_43fd_aea5_cce5cdc742a0
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q6IBC4
is encoded by: hsa:4726
boundary condition: true
has only substance units: false
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110018#_c48425e7_04f5_46a6_83b4_b6e4497c1ddf
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: PDE9A
type: Species

metaM lnlc e
is: SBO:0000247
name: linoleate
initial concentration: 1.0
is: CHEBI:30245
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM HC01496 m
is: SBO:0000247
is: CHEBI:28095
name: 2-Amino-3-oxoadipate
initial amount: NaN
constant: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR G13MT U
is version of: http://identifiers.org/ec-code/2.4.1.132
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110018#_9a3d9449_3e13_4938_b302_1a2ae57c7c57
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: G3V5N0
is encoded by: hsa:2530
type: Species
name: FUT8
initial amount: NaN

metaR PI345P3P
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: false
reactant: MODEL1310110018#
fast: false
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.67
modifier: MODEL1310110018#
is described by: ECO:0000000

metaR FAEL205
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)
product: MODEL1310110018#

metaM cdp c
name: CDP
initial concentration: 1.0
is: HMDB01546
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: C00112
has only substance units: false
type: Species
is: CHEBI:58069
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_37727f1e_2de2_4882_aae2_9dc5aed60c92
type: Species
has only substance units: false
boundary condition: true
is: Q9UN76
name: SLC6A14
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11254

metaR r0541
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110018#

metaR UAGDP
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
product: MODEL1310110018#
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110018#

metaR UNK3
is: SBO:0000176
fast: false
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
name: 2-keto-4-methylthiobutyrate transamination
kinetic law: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_c86d3967_502c_406f_b79e_c35a8f8ae981
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: PIGO
has only substance units: false
type: Species
is encoded by: hsa:84720
initial concentration: NaN

metaR r2388
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reactant: MODEL1310110018#

metaR THMP
name: thiamin phosphatase
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: false

metaR S6TASE12ly
is described by: ECO:0000000
product: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110018#
reactant: MODEL1310110018#

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: Glycerol 3-phosphate
is: HMDB00126
boundary condition: false
is: C00093
is: CHEBI:57597
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_a97710a1_1947_4c5a_8f18_39c659889e05
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2878
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: GPX3
constant: false
is: P22352

metaR HS3ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110018#
reversible: false
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.10.1.1
reactant: MODEL1310110018#

metaM HC01406 m
boundary condition: false
is: SBO:0000247
name: 3-Oxooctanoyl-CoA
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28264

metaM lnlc c
name: linoleate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: CHEBI:30245
type: Species
boundary condition: false
is: HMDB00673
has only substance units: false
initial amount: NaN
constant: false

metaR MTHFD2m
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000254
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110018#

metaR r2387
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7c0954d7_3bff_472d_b54d_9dff7fb4bff4
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q7GXZ1
name: ND6
initial amount: NaN
is encoded by: hsa:4541
initial concentration: NaN
type: Species

metaM debrisoquine c
has only substance units: false
initial amount: NaN
is: HMDB06543
type: Species
is: CHEBI:34665
constant: false
name: debrisoquine
is: SBO:0000247
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
initial concentration: 1.0
boundary condition: false

metaM idp n
is: SBO:0000247
is: CHEBI:58280
is: HMDB03335
type: Species
name: IDP(3-)
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM 5thf e
constant: false
has only substance units: false
type: Species
name: pentaglutamyl folate (THF)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06487
notes: FORMULA: C39H45N11O18 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110018#_76bdc8ae_6c9e_4093_b373_aae43a8cb9af
type: Species
boundary condition: true
is: B4DZR2
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8854
initial amount: NaN
name: ALDH1A2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_29850399_94c9_4490_a3f8_924c314c2015
initial amount: NaN
is: Q13123
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3550
initial concentration: NaN
name: IK
boundary condition: true

metaR r2386
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
modifier: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_ef83d4ba_f777_4826_8b90_94f8d9d47523
is: SBO:0000252
is: P48426
constant: false
has only substance units: false
name: PIP4K2A
type: Species
is encoded by: hsa:5305
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM cdp e
constant: false
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
boundary condition: false
has only substance units: false
is: CHEBI:58069
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

metaM CE0713 m
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30623
has only substance units: false
name: 3-oxolinoleoyl-CoA
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN
boundary condition: false
is: HMDB02329
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_59b63957_baaa_4ca2_8b8d_6a62492efb96
is: Q546H9
name: ALDH5A1
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7915
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ac11f190_39ec_4538_a6e8_23351d7491d3
is: SBO:0000252
is: Q9BZV2
initial concentration: NaN
name: SLC19A3
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:80704
has only substance units: false

metaR r0842
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Postulated transport reaction
fast: false

metaR SPRMS
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
reversible: false
name: spermine synthase
is version of: http://identifiers.org/ec-code/2.5.1.22
modifier: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
kinetic law: MODEL1310110018#
is described by: ECO:0000269

metaM doco13ecoa x
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
name: 13-docosenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892791
type: Species
initial amount: NaN

metaR FMNAT
kinetic law: MODEL1310110018#
is described by: ECO:0000134
product: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
name: FMN adenylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.2
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#

metaR r2385
modifier: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
fast: false

metaR NPTHLte
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110018#
fast: false
name: xenobiotic transport

metaR PROSTGI2t
reversible: true
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: Prostaglandin I2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaR NAt3 1
reversible: true
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
name: sodium proton antiporter (H:NA is 1:1)

metaM gdp n
boundary condition: false
name: GDP(3-)
is: CHEBI:58189
is: HMDB01201
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM biocyt m
is: C05552
type: Species
has only substance units: false
constant: false
name: Biocytin
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
is: HMDB03134
initial concentration: 1.0

metaR LNLCCPT2
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
modifier: MODEL1310110018#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_87df4283_d3c1_4a28_b8e4_565b11cdb9d5
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6520
constant: false
is: P08195
name: SLC3A2
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r2384
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
reversible: false

metaR DAG HSter
kinetic law: MODEL1310110018#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
name: diacylglycerol ER export

metaR P5CDm
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
modifier: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110018#

metaM gdp m
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58189
boundary condition: false
name: GDP
constant: false

metaR DOLMANP Uter
reversible: false
product: MODEL1310110018#
is: SBO:0000185
name: dolichol-phosphate mannose flippase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_207dc161_da1a_4dd8_aa82_8272c21eabd2
is encoded by: hsa:5138
initial concentration: NaN
boundary condition: true
is: Q8IW54
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: PDE2A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_85eee654_93b1_49ad_bd6c_3e86cd122493
is encoded by: hsa:54511
has only substance units: false
initial concentration: NaN
constant: false
is: Q9NT06
name: HMGCLL1
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaR LNLCCPT1
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_02816dbc_5de5_47b2_92e1_7f4f5982cadc
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q6GTM5
is encoded by: hsa:6309
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: SC5DL

metaM cs e deg2 l
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
initial amount: NaN
is: HMDB00812
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
initial concentration: 1.0

metaR r0840
kinetic law: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
name: Free diffusion
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.13.70
reversible: true
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_a9af2818_523e_4de8_a0c7_b5cecb08297e
constant: false
type: Species
has part: O00330
is encoded by: hsa:8050
initial amount: NaN
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:1738
is encoded by: hsa:4967
boundary condition: true
initial concentration: NaN
has part: Q02218
is encoded by: hsa:1743
has part: P36957
has only substance units: false
is: SBO:0000297
has part: P09622

http://identifiers.org/biomodels.db/MODEL1310110018#_f36f5b5c_0459_4075_9ce8_0c9a99324cc6
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10331
constant: false
name: B3GNT3
is: Q9Y2A9
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_8b7579f5_128c_44f8_a090_a3469bc5103e
initial amount: NaN
constant: false
name: GAPDHS
boundary condition: true
is: O14556
type: Species
is encoded by: hsa:26330
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM galgluside hs c
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
is: HMDB06535
initial concentration: 1.0
initial amount: NaN
name: galactosyl glucosyl ceramide
boundary condition: false
constant: false
type: Species

metaR DHORD9
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaM gbside hs g
name: globoside
type: Species
is: CHEBI:18259
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM damp c
boundary condition: false
initial amount: NaN
constant: false
name: dAMP(2-)
has only substance units: false
is: HMDB00905
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
type: Species
is: CHEBI:58245

metaR MGSA2
is: SBO:0000176
reactant: MODEL1310110018#
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
type: Reaction
fast: false
kinetic law: MODEL1310110018#
name: methyglyoxylate synthase 2 (from g3p)

metaR BHBtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
product: MODEL1310110018#
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#

metaR r0841
is version of: http://identifiers.org/ec-code/1.1.1.271
product: MODEL1310110018#
name: Free diffusion
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
type: Reaction
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_0cbea6c4_4719_4c0d_9811_79d274af6d59
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q4FEB3
type: Species
name: CMA1
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1215

metaR CDIPTr
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.11
modifier: MODEL1310110018#

metaM anth e
is: SBO:0000247
is: HMDB01123
has only substance units: false
name: anthranilate
constant: false
initial amount: NaN
type: Species
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0
boundary condition: false

metaR NTD11
modifier: MODEL1310110018#
reversible: false
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000269
name: 5'-nucleotidase (IMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
product: MODEL1310110018#

metaR HEXCCOAtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: fatty acid intracellular transport
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
fast: false

metaR RE0452M
reversible: true
fast: false
is: SBO:0000176
name: RE0452
kinetic law: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_ac384551_ad58_4d23_8f0c_a13218c2a800
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B4DG68
is encoded by: hsa:4842
type: Species
is: SBO:0000252
name: NOS1
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_b4b5b8bc_ceb3_47d6_bb0c_d0d7ddcc27c5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:H53099
initial amount: NaN
type: Species
has only substance units: false
name: _H53099_1_m
constant: false
initial concentration: NaN

metaR NDPK5
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_ec4ca4ce_f115_46d9_ab10_3d48e98a224c
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:51196
constant: false
has only substance units: false
initial amount: NaN
is: Q9P212
boundary condition: true
name: PLCE1

metaR PUNP7
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
modifier: MODEL1310110018#
type: Reaction
fast: false
reactant: MODEL1310110018#
name: purine-nucleoside phosphorylase (Xanthosine)

http://identifiers.org/biomodels.db/MODEL1310110018#_560d4984_ae1f_4da5_81d8_588f25aacb74
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:126129
name: CPT1C
has only substance units: false
initial concentration: NaN
is: Q8TCG5

http://identifiers.org/biomodels.db/MODEL1310110018#_9d689d99_8c64_4959_91de_551737e92027
is: SBO:0000252
boundary condition: true
constant: false
name: NDUFC1
initial amount: NaN
is encoded by: hsa:4717
has only substance units: false
type: Species
is: O43677
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_cfd65300_fa78_4ff2_991e_dfe17ef16d15
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_653aea97_90f3_4eef_9f88_bbdf2cad2a9b
is: P30837
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:219
is: SBO:0000252
constant: false
boundary condition: true
name: ALDH1B1

metaM lnlccoa r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
is: SBO:0000247
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: linoleic coenzyme A

metaR r0549
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.1.1.17
type: Reaction

metaR NTD10
fast: false
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110018#
reversible: false
is described by: ECO:0000254
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
product: MODEL1310110018#
name: 5'-nucleotidase (XMP)
is: SBO:0000176

metaM dlnlcgcoa r
has only substance units: false
is: C03595
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_02948e18_a5fd_466a_97a9_e321c6c904fd
initial concentration: NaN
is encoded by: hsa:23428
initial amount: NaN
type: Species
is: SBO:0000252
is: Q86U05
boundary condition: true
has only substance units: false
constant: false
name: SLC7A8

metaM HC00250 e
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: hydrosulfide
has only substance units: false
is: CHEBI:29919
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaM 4abutn m
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01080
constant: false
boundary condition: false
initial concentration: 1.0

metaM lcts e
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00243
is: HMDB00186
is: CHEBI:17716
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
name: Lactose
has only substance units: false

metaM ivcoa m
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57345
is: HMDB01113
name: Isovaleryl-CoA

metaR NDPK4
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110018#
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110018#

metaR 34HPPOR
is: SBO:0000176
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
type: Reaction

metaR PUNP6
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000269
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyinosine)

metaM hs deg25 l
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16126
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1

metaM anth c
name: anthranilate
is: SBO:0000247
is: HMDB01123
type: Species
initial amount: NaN
constant: false
is: CHEBI:16567
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9b0f01b7_d3b3_4a3a_8f08_6e1fca224bb8
has only substance units: false
name: ALPP
is: SBO:0000252
is encoded by: hsa:250
boundary condition: true
constant: false
is: P05187
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_eff04459_350d_4bef_89d2_5d34a5be3849
boundary condition: true
initial concentration: NaN
is: Q53F23
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6916
constant: false
has only substance units: false
name: TBXAS1

metaR FRUt4
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
name: D-fructose transport via sodium cotransport
modifier: MODEL1310110018#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110018#

metaR NDPK7
type: Reaction
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110018#
is described by: ECO:0000269
kinetic law: MODEL1310110018#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP)
fast: false

metaR PE HSter
fast: false
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaM adpcoa x
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
has only substance units: false
boundary condition: false
initial amount: NaN
name: adipoylcoa
initial concentration: 1.0
constant: false
is: C14143
type: Species
is: SBO:0000247
is: HMDB04047

http://identifiers.org/biomodels.db/MODEL1310110018#_58ee3a2f_f5c6_48ff_ab73_72ce58794ffb
is: B4DUY1
constant: false
is encoded by: hsa:10948
initial concentration: NaN
initial amount: NaN
name: STARD3
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM m5masnB2 g
boundary condition: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
is: CHEBI:58282
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB00968

metaM HC00250 c
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: hydrosulfide
constant: false
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaR GLNLASEer
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
product: MODEL1310110018#
name: gluconolactonase, endoplasmic reticulum

metaM fadh2 m
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
type: Species
boundary condition: false
is: C01352
is: HMDB01197
is: SBO:0000247
is: CHEBI:58307
initial amount: NaN
has only substance units: false

metaR NDPK6
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dUDP)

http://identifiers.org/biomodels.db/MODEL1310110018#_d3cfc9ab_3a97_4e17_bbf6_33122cc87f15
initial concentration: NaN
is encoded by: hsa:9435
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: CHST2
is: Q9Y4C5
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9811e633_3181_4c26_9f67_7cbfd326fd8d
type: Species
constant: false
name: HEXA
initial concentration: NaN
is encoded by: hsa:3073
boundary condition: true
is: P06865
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GLYBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
type: Reaction
product: MODEL1310110018#
fast: false
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
kinetic law: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110018#
reversible: true

metaM 3docopencoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_30f076ea_320b_4809_b001_293b2928935d
has only substance units: false
constant: false
is: SBO:0000252
name: _AA021081_1_r
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA021081

http://identifiers.org/biomodels.db/MODEL1310110018#_e2adc1a0_54d5_4992_b86c_572ca28a1169
boundary condition: true
type: Species
name: CYP51A1
initial amount: NaN
initial concentration: NaN
is: Q16850
constant: false
is encoded by: hsa:1595
is: SBO:0000252
has only substance units: false

metaR NDPK10
fast: false
product: MODEL1310110018#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dIDP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaR HSPASEly
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_94783236_b7b7_4941_b5fc_a90d75d4a9a4
is: Q8NFF2
is encoded by: hsa:123041
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC24A4
is: SBO:0000252
initial amount: NaN

metaR UREAt
fast: false
is described by: ECO:0000269
name: Urea transport via facilitate diffusion
reversible: true
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_1b657df6_2a90_4c51_8c2c_2a4d6122758a
constant: false
boundary condition: true
name: AK3
is: SBO:0000252
is encoded by: hsa:50808
initial amount: NaN
has only substance units: false
is: E7ET30
initial concentration: NaN
type: Species

metaM bilirub e
is: CHEBI:57977
is: HMDB00054
has only substance units: false
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: proton
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110018#_998698bc_63d3_4c8c_9ea5_7ac5b1f0da2a
name: SLC5A2
is: P31639
is encoded by: hsa:6524
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR RETH2e
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: retinyl ester hydrolase (11-cis), extracellular
is described by: ECO:0000000

metaR UDPGD
name: UDPglucose 6-dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.22
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_9707d50f_2a8b_4543_b373_b303f292c0ce
has only substance units: false
is encoded by: hsa:1962
name: EHHADH
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9NY65
constant: false

metaR NDPK9
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_6ebfcc29_a807_42f3_90f1_3146aa0e915f
initial concentration: NaN
name: G6PC3
boundary condition: true
type: Species
is encoded by: hsa:92579
constant: false
is: Q9BUM1
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR OCCOAtm
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
type: Reaction
name: Octanoyl-CoA transport, diffusion

metaR PACCOAL
reversible: false
type: Reaction
kinetic law: MODEL1310110018#
fast: false
name: phenylacetate-CoA ligase
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110018#

metaM prostgi2 c
name: prostaglandin I2(1-)
is: CHEBI:57403
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB01335

metaR r0545
modifier: MODEL1310110018#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110018#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM urcan c
initial concentration: 1.0
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: Urocanate
is: C00785
is: HMDB00301
is: CHEBI:17771
boundary condition: false
has only substance units: false

metaM HC00342 c
is: CHEBI:16383
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
type: Species
name: cis-aconitate(3-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_e749217a_ca07_4bed_b9e1_0c7ac951358c
is: SBO:0000252
is encoded by: hsa:3156
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: P04035
constant: false
initial amount: NaN
name: HMGCR

metaR PROSTGF2t
is: SBO:0000185
name: prostaglandin uniport
type: Reaction
kinetic law: MODEL1310110018#
reversible: true
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269

metaR NDPK8
reactant: MODEL1310110018#
type: Reaction
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dADP)
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaM ksi pre14 g
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
type: Species
has only substance units: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_3a16f3ad_2dd5_4e45_8709_f61b08294324
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:501
has only substance units: false
is: E7EPT3
type: Species
constant: false
name: ALDH7A1
is: SBO:0000252

metaM dhcholestanate x
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: HMDB00359
initial amount: NaN

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_25c79893_ea58_4a5a_9aef_1772c3d48397
boundary condition: true
is: Q9Y217
has only substance units: false
constant: false
is encoded by: hsa:9107
initial amount: NaN
is: SBO:0000252
name: MTMR6
initial concentration: NaN
type: Species

metaM bilirub c
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: bilirubin(2-)
is: HMDB00054
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_115a3db6_d24a_4655_8af9_acfa82d0d3cc
is encoded by: hsa:314
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: AOC2
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_437b5e64_bd40_4efe_bc03_41a5d00e0a76
is encoded by: hsa:122481
has only substance units: false
constant: false
initial amount: NaN
is: Q96M32
name: AK7
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM fum c
name: Fumarate
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00134
is: C00122
constant: false
has only substance units: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN

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type: Species
is encoded by: hsa:AI348006
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI348006_1_c

http://identifiers.org/biomodels.db/MODEL1310110018#_8b5c237a_3dd5_48ba_a0e3_ee69bf9b57a4
is: O75106
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:314
type: Species
boundary condition: true
name: AOC2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_06355454_8a2e_4c03_8a09_226c23442d34
name: PRDX1
initial amount: NaN
is encoded by: hsa:5052
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR NACHEX23ly
modifier: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal

metaM fol m
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
initial amount: NaN
boundary condition: false
is: CHEBI:27470
initial concentration: 1.0
is: SBO:0000247
name: Folate
type: Species
has only substance units: false
is: HMDB00121
constant: false

metaR BPNT
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.7
is: SBO:0000176
kinetic law: MODEL1310110018#
name: 3',5'-bisphosphate nucleotidase
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2bd7e2c2_49dc_4cb2_a93f_02e38274e375
type: Species
is: Q86XP1
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:160851
is: SBO:0000252
name: DGKH
initial amount: NaN
has only substance units: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR NCKt
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is: SBO:0000185
modifier: MODEL1310110018#
type: Reaction

metaM HC02203 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27820
type: Species
name: prostaglandin-a2
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_0e89df4d_4f60_4b5f_a307_6ec56249c9a3
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: _100287639_1_c
boundary condition: true
is encoded by: hsa:100287639
has only substance units: false
constant: false

metaR HSD3B11
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
fast: false
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is described by: ECO:0000134
product: MODEL1310110018#
kinetic law: MODEL1310110018#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
reversible: false

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00121
has only substance units: false

metaR r0437
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is: SBO:0000176
reversible: true

metaM m4masn g
has only substance units: false
type: Species
is: C05881
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C46H77N2O35X CHARGE: 0

metaM mercplaccys e
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
is: HMDB06512
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_1a0a151e_8236_40be_ad5e_f5f9e5241464
initial concentration: NaN
type: Species
name: GCK
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2645

http://identifiers.org/biomodels.db/MODEL1310110018#_c776ce4d_dad5_44a2_ab1d_f4be8163d250
boundary condition: true
is: Q70HW3
has only substance units: false
name: SLC25A26
type: Species
is encoded by: hsa:115286
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR DOPAt4 2 r
reactant: MODEL1310110018#
name: Dopamine reversible transport in via sodium symport (1:2)
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110018#_adc9b048_923a_49a5_b057_67b2c5b54797
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P51828
is encoded by: hsa:113
constant: false
name: ADCY7

metaM hs deg1 l
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: heparan sulfate, degradation product 1
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:17180
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: HMDB01352

metaM csn e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16040
is: HMDB00630
constant: false
initial amount: NaN
name: cytosine
boundary condition: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species

metaM 10fthf6glu e
constant: false
boundary condition: false
is: CHEBI:16236
is: SBO:0000247
is: HMDB00108
initial amount: NaN
type: Species
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
has only substance units: false
initial concentration: 1.0

metaM 4abutn e
type: Species
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: HMDB01080
name: 4-ammoniobutanal
initial amount: NaN
has only substance units: false
is: CHEBI:58264
boundary condition: false
initial concentration: 1.0

metaR RTOTALFATPc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_d541908d_5cb5_408c_94fc_2e35f324aa91
name: H6PD
is encoded by: hsa:9563
boundary condition: true
has only substance units: false
is: O95479
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR NADPHtru
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
name: NADPH transporter, endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
is described by: ECO:0000000

metaR CYTK12n
modifier: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
fast: false
name: cytidylate kinase (dCMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110018#

metaM ksi pre3 g
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 3
is: HMDB06552
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
is: CHEBI:2504
initial amount: NaN

metaM HC02203 e
constant: false
initial concentration: 1.0
name: prostaglandin-a2
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2ecc4ff7_d2fa_40d5_9558_19579e7ae4f8
boundary condition: true
constant: false
initial concentration: NaN
name: UGP2
initial amount: NaN
type: Species
is encoded by: hsa:7360
has only substance units: false
is: SBO:0000252

metaR ADK1
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110018#
reactant: MODEL1310110018#

metaR EX mepi LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Metanephrine exchange
type: Reaction

metaR r1658
is described by: ECO:0000000
modifier: MODEL1310110018#
reversible: true
type: Reaction
reactant: MODEL1310110018#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_77d2475a_599f_4b1f_ae63_55b2f573cf49
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC7A8
is encoded by: hsa:23428
is: Q9UHI5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_61bceeb5_324e_44d8_8bb5_189e4968f8fc
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4881
boundary condition: true
is: P16066
has only substance units: false
type: Species
name: NPR1

http://identifiers.org/biomodels.db/MODEL1310110018#_c61cfdc9_2e88_44e3_8bf4_dbd80626d81c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:79966
name: SCD5
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q86SK9

http://identifiers.org/biomodels.db/MODEL1310110018#_701eb71b_c98f_4dfd_9ccc_178898125d09
type: Species
has part: Q8WYR1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:23533
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: PIK3R5:PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110018#_e6ef49be_00be_4365_bfa9_e516aabb6df3
type: Species
has only substance units: false
is: P23786
name: CPT2
constant: false
is encoded by: hsa:1376
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_f5d1c739_e43b_40f9_a14f_20f0c20321c2
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110018#_4efa4ee0_289e_41e1_8eac_65b02aacbd62
constant: false
is: SBO:0000252
name: AK4
has only substance units: false
initial amount: NaN
is encoded by: hsa:205
is: P27144
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_a6ac67a9_0f4b_44b0_ad15_933664660df2
initial amount: NaN
name: ALDH1A3
is: SBO:0000252
is encoded by: hsa:220
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: P47895

metaM 4abutn c
type: Species
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
has only substance units: false
is: HMDB01080
is: C00555
boundary condition: false
is: CHEBI:58264
initial amount: NaN
initial concentration: 1.0
name: 4-Aminobutanal

metaR RE1519M
is: SBO:0000176
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
name: RE1519
reversible: true
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR GLCAASE7ly
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110018#
is: SBO:0000176
product: MODEL1310110018#
name: beta-glucuronidase, lysosomal
reversible: false
reactant: MODEL1310110018#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r2051
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#

metaR r1659
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM acetone c
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB01659
boundary condition: false
is: CHEBI:15347
initial amount: NaN
is: SBO:0000247

metaR ASNtN1
kinetic law: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110018#
type: Reaction
reversible: true
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Asparagine transport (Na, H coupled)

metaM HC00342 m
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false
is: CHEBI:16383
name: cis-aconitate(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR URIt5le
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110018#
is described by: ECO:0000134
name: uridine transport in via sodium symport (1:2)
is: SBO:0000185
fast: false
reactant: MODEL1310110018#
reversible: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_8e5313a7_de87_408e_ba6f_cd8354289528
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q96NR8
is encoded by: hsa:145226
type: Species
name: RDH12

metaM prostgi2 e
type: Species
constant: false
name: prostaglandin I2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
initial amount: NaN
is: HMDB01335
boundary condition: false
initial concentration: 1.0
is: CHEBI:57403

metaM gdp c
is: HMDB01201
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: C00035
is: CHEBI:58189
is: SBO:0000247
name: GDP

metaR r0295
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110018#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false

metaR PUNP3
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: purine-nucleoside phosphorylase (Guanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: HMDB00256
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: squalene
is: CHEBI:15440

metaR ADK3
type: Reaction
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is described by: ECO:0000269
name: adentylate kinase (GTP)
modifier: MODEL1310110018#

metaR PUNP2
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_2052d6cf_7e16_48f7_9c5f_d050d6d14fbb
is encoded by: hsa:AI024818
name: _AI024818_1_c
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM acetone e
is: SBO:0000247
type: Species
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
is: HMDB01659
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15347
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ebb80340_f922_4845_ae5a_71d25a592b33
constant: false
is: SBO:0000252
has only substance units: false
name: _AI191472_1_c
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI191472

metaM gchola c
is: CHEBI:58235
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00138
name: glycocholate
has only substance units: false

metaR r1942
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110018#
name: Y+LAT2 Utilized transport
product: MODEL1310110018#

metaM cbasp c
boundary condition: false
is: CHEBI:32814
type: Species
name: N-Carbamoyl-L-aspartate
constant: false
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: SBO:0000247
is: C00438
has only substance units: false
initial concentration: 1.0
is: HMDB00828

metaR PUNP1
name: purine-nucleoside phosphorylase (Adenosine)
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_355f62f8_49e0_4d15_8c83_2df74c4b1a0a
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:477
is: SBO:0000297
has only substance units: false
constant: false
has part: P50993
name: ATP1B4:ATP1A2
is encoded by: hsa:23439
has part: Q9UN42

http://identifiers.org/biomodels.db/MODEL1310110018#_5a8a9f08_faa2_47bf_a4d7_3a75168cc486
is: Q4G1C4
constant: false
initial amount: NaN
is encoded by: hsa:284273
type: Species
name: ZADH2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r2054
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_3efc7151_3ed8_4237_be70_b4e2706d3218
is: P00326
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:126
name: ADH1C
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaR PUNP5
reversible: true
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#

metaM mercplaccys c
initial amount: NaN
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06512

metaR SCP21cx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_01e57c1e_a430_458d_aa24_99dfbd53b578
name: GMDS
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2762
is: O60547
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM h r
boundary condition: false
is: CHEBI:24636
is: SBO:0000247
is: C00080
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR C226CPT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
modifier: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
reversible: false
name: C226 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110018#_efd47e71_46ef_4664_bb91_e6669349e286
is: B2R6S5
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: CMPK1
is encoded by: hsa:51727
is: SBO:0000252

metaR r1943
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_82259f19_53d6_4f11_bc62_04d2104b7a98
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q9P019
is: SBO:0000252
is encoded by: hsa:29085
name: PHPT1

metaM ksi deg15 l
type: Species
name: keratan sulfate I, degradation product 15
is: CHEBI:12936
is: HMDB00143
has only substance units: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaM fadh2 r
is: CHEBI:58307
is: HMDB01197
name: FADH2(2-)
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_38da14ca_9c6f_42ca_afb9_ef0d2daa7e1f
has part: P31350
initial amount: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:6240
has part: P23921
name: RRM1:RRM2
boundary condition: true
is encoded by: hsa:6241
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_37da5351_99a0_4fa3_b99d_d27d48dc8f9b
is: Q16790
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: CA9
is encoded by: hsa:768
initial concentration: NaN

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_07f42bb5_fa6b_49ca_b0d0_9f43ed0e68ec
name: LDHB
initial amount: NaN
is encoded by: hsa:3945
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: P07195
boundary condition: true
type: Species

metaR PUNP4
product: MODEL1310110018#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is: SBO:0000176
modifier: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR C226CPT1
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: carnitine C22:6 transferase
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_98c9991b_61ef_414b_b47c_dbf00b2ab476
is: Q11203
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN

metaM gchola e
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: glycocholate
has only substance units: false
is: HMDB00138
constant: false
type: Species

metaM dlnlcgcoa c
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
type: Species
constant: false
is: CHEBI:27979
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_103685aa_721b_4f31_929e_9c9a23ec1657
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
has part: P22392
is encoded by: hsa:4831
has part: P15531
type: Species
is: SBO:0000297
constant: false
name: NME1:NME2
boundary condition: true
initial concentration: NaN

metaR 3HKYNAKGAT
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is described by: ECO:0000304
fast: false
type: Reaction
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaM csn c
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16040
is: HMDB00630
name: cytosine
constant: false
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

metaM dolglcp U r
constant: false
is: CHEBI:15812
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
initial concentration: 1.0

metaM fuc1p L c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: L-Fucose 1-phosphate
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
has only substance units: false
type: Species
constant: false
is: HMDB01265
is: CHEBI:28319

metaM dcacoa m
initial concentration: 1.0
type: Species
is: CHEBI:61430
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06404
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false

metaM ksi pre20 g
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 20
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_47e5204f_2a07_40a4_99c0_990e05e9575a
type: Species
is encoded by: hsa:3423
boundary condition: true
is: B4DGD7
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: IDS
constant: false

metaR S4TASE2ly
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12

metaM dgmp c
has only substance units: false
is: C00362
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
name: dGMP
type: Species
is: CHEBI:57673
constant: false
is: SBO:0000247

metaM lac L c
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: SBO:0000247
is: HMDB00190
name: (S)-lactate

metaR KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
name: KHte

MODEL1310110018
reaction: metaR r2001
species: metaM m1mpdol U c
reaction: metaR PNP
reaction: metaR RE0830N
reaction: metaR NTD10
species: metaM pi e
reaction: metaR r1620
reaction: metaR r0590
reaction: metaR r2193
species: metaM ade e
reaction: metaR URCN
species: metaM ocdcea c
species: metaM occoa c
reaction: metaR EX adp
reaction: metaR r0488
species: metaM ksi deg32 l
species: metaM acnam l
reaction: metaR SUBERCACT
reaction: metaR r1446
reaction: metaR UMPK6
species: metaM atp n
species: metaM pchol hs r
species: metaM dttp c
species: metaM 2kmb c
reaction: metaR C4STMO2Pr
reaction: metaR EX 5mthf LPAREN e RPAREN
reaction: metaR TXA2tr
reaction: metaR 5MTHFt
species: metaM urate e
reaction: metaR 2HBt2
reaction: metaR r2086
reaction: metaR C160CPT2
reaction: metaR r2355
reaction: metaR GluForTx
species: metaM CE5160 r
species: metaM eicostet e
reaction: metaR EX cytd LPAREN e RPAREN
reaction: metaR AG13T17g
species: metaM ppi m
species: metaM lnlnca c
reaction: metaR AICART
species: metaM HC02121 c
reaction: metaR r2324
reaction: metaR r0940
species: metaM 5mta c
species: metaM aps c
reaction: metaR F6Tg
reaction: metaR r0009
species: metaM CE1936 e
species: metaM idour e
reaction: metaR DOLPMT2 Uer
species: metaM nadph x
reaction: metaR r1583
reaction: metaR FACOAL184
reaction: metaR Htg
reaction: metaR EX gly LPAREN e RPAREN
reaction: metaR r2401
reaction: metaR FACOAL180i
species: metaM lys L e
species: metaM prostgh2 r
reaction: metaR RE3346M
reaction: metaR r0782
reaction: metaR EX psyl LPAREN e RPAREN
reaction: metaR BETALDHxm
species: metaM acald c
reaction: metaR NAt5
species: metaM ura e
reaction: metaR EX C05965 LPAREN e RPAREN
reaction: metaR PRGSTRNt
species: metaM 3m4hpga m
reaction: metaR r0268
reaction: metaR AG13T1g
reaction: metaR EX leuktrC4 LPAREN e RPAREN
reaction: metaR RE0689E
species: metaM trp L e
species: metaM HC01405 m
species: metaM thym e
species: metaM xoldioloneh c
reaction: metaR S6T7g
species: metaM ksi deg1 e

http://identifiers.org/biomodels.db/MODEL1310110018#_bc6d4eaf_af39_43f0_858c_aa5bd5287a04
type: Species
name: _U37519_1_e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U37519
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR r1665
modifier: MODEL1310110018#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_74dbfc0d_0055_4cb4_930b_3a1defe23c6a
name: ITPKC
is: Q96DU7
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:80271

metaM hs deg10 l
is: HMDB00127
name: heparan sulfate, degradation product 10
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:15748
type: Species
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: SBO:0000247
initial amount: NaN

metaM 3ohdcoa m
name: 3-oxopalmitoyl-CoA(4-)
constant: false
is: HMDB06402
is: CHEBI:57349
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false

metaR r2390
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_b521df1f_683b_4228_ac0d_359698cb3e7b
constant: false
type: Species
is: SBO:0000252
is: O00459
initial concentration: NaN
is encoded by: hsa:5296
initial amount: NaN
boundary condition: true
name: PIK3R2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9fa0c861_6f15_479d_9ddd_3b2405ef5936
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11001
name: SLC27A2
is: O14975
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR UREAtm
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: Urea transport via diffusion
product: MODEL1310110018#
fast: false
reversible: true
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110018#
type: Reaction

metaR ICDHyrm
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110018#
name: Isocitrate dehydrogenase (NADP+)
reactant: MODEL1310110018#
modifier: MODEL1310110018#
reversible: true
is: SBO:0000176

metaM spc hs c
type: Species
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0

metaM fum m
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
is: C00122
boundary condition: false
initial concentration: 1.0
is: HMDB00134
is: CHEBI:29806
has only substance units: false
constant: false
name: Fumarate
initial amount: NaN

metaR ALAGLNNaEx
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
is: SBO:0000185
reactant: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
reversible: false
fast: false

metaR r1664
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PROSTGE2t2
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
reactant: MODEL1310110018#
name: prostaglandin uniport
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaR ADPCOACROT
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial concentration: 1.0
has only substance units: false
name: dGMP(2-)
initial amount: NaN
is: HMDB01044
constant: false
boundary condition: false
type: Species
is: CHEBI:57673
is: SBO:0000247

metaM ptth m
constant: false
boundary condition: false
is: HMDB03426
is: SBO:0000247
name: pantetheine
has only substance units: false
type: Species
is: CHEBI:16753
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN

metaR O2Stm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110018#

metaM cbasp e
is: CHEBI:32814
constant: false
name: N-Carbamoyl-L-aspartate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: SBO:0000247
has only substance units: false
is: HMDB00828
is: C00438
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_0837e905_f127_407a_87b4_1b29544fbb24
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: OXSM
constant: false
is encoded by: hsa:54995
boundary condition: true
is: Q9NWU1
initial amount: NaN

metaM docohepcoa m
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
type: Species
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
initial amount: NaN

metaR GLYSNAT5tc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM 11 cis retfa e
is: HMDB00108
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:16236
initial concentration: 1.0
initial amount: NaN
type: Species
name: fatty acid 11-cis-retinol
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7b526ee3_7bc1_423b_b146_fe23636922a7
type: Species
is: A6NFM2
initial amount: NaN
boundary condition: true
has only substance units: false
name: PYCR1
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:5831

http://identifiers.org/biomodels.db/MODEL1310110018#_b3aca1b0_ac3e_49ae_a2cf_3d08ae1ab8a0
is encoded by: hsa:9990
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
name: SLC12A6
is: Q9UHW9
initial amount: NaN
initial concentration: NaN

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ab4f785c_a99f_416b_aacd_c49146047cbf
type: Species
name: NDUFA6
boundary condition: true
is: P56556
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4700
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_7023afcb_4529_4813_b20f_ae55e9039b62
is: SBO:0000252
initial concentration: NaN
is: Q1EHB4
is encoded by: hsa:159963
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: SLC5A12

http://identifiers.org/biomodels.db/MODEL1310110018#_02387d76_da44_440a_a0eb_e176b813a353
has only substance units: false
name: HSD11B1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3290
boundary condition: true
type: Species

metaR O2Stn
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
type: Reaction
name: superoxide anion transport via diffusion (nucleus)
reactant: MODEL1310110018#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110018#

metaR LPCHOLt
kinetic law: MODEL1310110018#
name: lysophosphatidylcholine transport
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
fast: false
reactant: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_b2670968_5a2b_4ec1_9e19_6f6667f69e78
boundary condition: true
is: Q6FH11
is encoded by: hsa:3162
has only substance units: false
name: HMOX1
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR PI5P3K
name: phosphatidylinositol-5-phosphate 3-kinase
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.137
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
fast: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR G6PDH1rer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
is: SBO:0000176
reactant: MODEL1310110018#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
modifier: MODEL1310110018#
is described by: ECO:0000269
product: MODEL1310110018#
reversible: true
fast: false

metaR ME2
is: SBO:0000176
name: malic enzyme (NADP)
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
product: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.40
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000

metaR RE3556C
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
name: RE3556
is: SBO:0000176

metaR r1662
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110018#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110018#
is: SBO:0000185

metaR SMS
product: MODEL1310110018#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.27
reactant: MODEL1310110018#
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_10fc3ad7_8e68_4c72_b679_56f4f650e955
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:H17063
name: _H17063_1_m
is: SBO:0000252

metaR RE0577C
product: MODEL1310110018#
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
is described by: ECO:0000000
name: RE0577
kinetic law: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction

metaM doco13ecoa c
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892791
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 13-docosenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110018#_0f89cd07_ee5c_4f67_8cd0_bfb45dafcd97
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: GPD1
is encoded by: hsa:2819
is: F8W1L5
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_ab2fdbea_86b0_4cd3_80a1_29499ad93bcd
type: Species
initial amount: NaN
name: SRD5A1
is encoded by: hsa:6715
has only substance units: false
constant: false
boundary condition: true
is: P18405
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_863f0679_3c28_46cf_99f0_3ad8bf23b66a
boundary condition: true
initial amount: NaN
name: FECH
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: P22830
initial concentration: NaN
is encoded by: hsa:2235

http://identifiers.org/biomodels.db/MODEL1310110018#_acc21007_8ae0_4300_b130_dcfb504cfe04
type: Species
is encoded by: hsa:158
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ADSL
has only substance units: false
constant: false
initial concentration: NaN

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR DGULND
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
type: Reaction
fast: false
is described by: ECO:0000000
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_19264430_551f_465e_8640_951f2811c3ed
boundary condition: true
initial amount: NaN
type: Species
name: PTGS1
is: P23219
initial concentration: NaN
is encoded by: hsa:5742
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110018#_0dd099f4_8105_47af_a32f_3e4c1fc6f8c3
has only substance units: false
initial amount: NaN
name: NMNAT3
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q96T66
is encoded by: hsa:349565

http://identifiers.org/biomodels.db/MODEL1310110018#_8afff513_7fae_4241_8adf_9a0a889ea194
type: Species
is encoded by: hsa:AI990637
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AI990637_1_x
has only substance units: false
boundary condition: true
constant: false

metaR GACPAILter
reversible: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_85156390_e5a8_46cc_8efc_9196a2c8dbf0
name: B4GALT5
is: O43286
boundary condition: true
is encoded by: hsa:9334
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR FAOXC201C181x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM dcacoa x
is: HMDB06404
initial concentration: 1.0
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: C05274

metaM mi13p c
is: CHEBI:18225
initial concentration: 1.0
type: Species
has only substance units: false
name: 1D-myo-Inositol 1,3-bisphosphate
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: HMDB06234
is: SBO:0000247

metaR DUMPtn
product: MODEL1310110018#
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
type: Reaction
name: dUMP nuclear transport
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true

metaM pglyc hs e
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: phosphatidylglycerol(1-)
type: Species
is: SBO:0000247
is: CHEBI:60523
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_219d5a8f_5af7_45e6_87b3_46d5b658c719
initial amount: NaN
is: SBO:0000252
is: Q16222
constant: false
has only substance units: false
boundary condition: true
name: UAP1
is encoded by: hsa:6675
type: Species
initial concentration: NaN

metaR GLCtly
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: glucose efflux from lysosome
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110018#
is: SBO:0000185

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110018#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110018#_c620f411_0956_4b71_8f03_196a82d8e72c
is encoded by: hsa:83884
initial amount: NaN
name: SLC25A2
constant: false
initial concentration: NaN
type: Species
is: Q9BXI2
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR LINKDEG2ly
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110018#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110018#
reversible: false

metaR NADH2 u10m
is: SBO:0000185
is described by: ECO:0000134
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
name: NADH dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
type: Reaction

metaM HC01231 c
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

http://identifiers.org/biomodels.db/MODEL1310110018#_759a33f6_3458_4410_a9d6_9adc6fe25f78
is: SBO:0000252
name: NDUFB6
type: Species
is: O95139
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4712

metaM lac L e
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
constant: false
is: SBO:0000247
name: (S)-lactate
type: Species
is: CHEBI:16651
boundary condition: false
is: HMDB00190
has only substance units: false

metaR ACGPID
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.89
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
product: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110018#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c6a4f524_5aad_4e23_8400_bf8ec9cf31a5
name: ACSL3
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O95573
constant: false
is encoded by: hsa:2181
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_024a66c2_e949_4656_bf64_cbac37aed74f
initial amount: NaN
is: O43280
initial concentration: NaN
boundary condition: true
name: TREH
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:11181

metaR DTMPKm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 17403938 NOTES:
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
name: dTMP kinase in mitochondria
product: MODEL1310110018#
fast: false
is described by: ECO:0000134

metaR RE3050R
is described by: ECO:0000000
name: RE3050
type: Reaction
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_194b3ec4_455b_45be_8b67_a92cae53cc8a
initial concentration: NaN
is: Q86VV3
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:953
name: ENTPD1
initial amount: NaN
boundary condition: true

metaR MM6B2g
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
product: MODEL1310110018#

metaR CYTK11
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (dCMP,dGTP)
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM prostgi2 r
constant: false
boundary condition: false
name: prostaglandin I2(1-)
is: HMDB01335
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
is: CHEBI:57403
type: Species

metaM pglyc hs c
name: phosphatidylglycerol(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:60523
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r1667
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR BTNDe
is version of: http://identifiers.org/ec-code/3.5.1.12
name: biotinidase (biotin), extracellular
kinetic law: MODEL1310110018#
reversible: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_987d735a_ac5f_4c54_94da_1144bbe35cca
constant: false
initial amount: NaN
is: P13196
type: Species
name: ALAS1
is: SBO:0000252
is encoded by: hsa:211
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR S6TASE20ly
type: Reaction
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_9d3af049_5ea0_4fb8_84f1_d65463b15a60
constant: false
is encoded by: hsa:LOC728997
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _LOC728997_1_c

metaM man1p c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06330
type: Species
is: CHEBI:35374
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial amount: NaN
constant: false

metaM cs b deg3 l
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: HMDB02704
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
is: CHEBI:21338

metaR THMMPtm
name: Thiamine monophosphate transport, mitochondrial
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
product: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true

metaR ESTRADIOLt
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110018#
reversible: true
name: estradiol transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_aea6c3ad_ba59_4ede_8867_2ac2745ac402
is: G5E960
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PLCB3
is encoded by: hsa:5331

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR CYTK10
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#

metaM thf c
initial concentration: 1.0
constant: false
type: Species
is: C00101
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
is: CHEBI:57453
boundary condition: false
is: HMDB01846
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR r1666
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000185
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM spc hs e
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
has only substance units: false

metaR FAOXC121C10x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_81ae9773_c12b_472a_89aa_708604f5a05c
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _J03866_1_m
is encoded by: hsa:J03866
type: Species
is: SBO:0000252
boundary condition: true

metaM ptth c
is: CHEBI:16753
initial amount: NaN
constant: false
is: HMDB03426
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaR r1384
reactant: MODEL1310110018#
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction
fast: false

metaM ksi deg18 l
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 18
type: Species
is: HMDB00143
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: SBO:0000247
constant: false
has only substance units: false

metaR HMBS
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.5.1.61
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176
name: hydroxymethylbilane synthase
product: MODEL1310110018#
is described by: ECO:0000254
kinetic law: MODEL1310110018#

metaM fadh2 c
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
is: CHEBI:58307
has only substance units: false
is: HMDB01197
name: FADH2(2-)
boundary condition: false

metaR r0553
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM HC01405 m
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
has only substance units: false
boundary condition: false
is: CHEBI:28632
initial concentration: 1.0
constant: false
name: (S)-Hydroxyoctanoyl-CoA

metaR RE2541E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110018#
name: RE2541

http://identifiers.org/biomodels.db/MODEL1310110018#_73c6cd55_81dc_41de_92f4_671ed41b1399
type: Species
initial amount: NaN
name: BCKDHB
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P21953
is encoded by: hsa:594
initial concentration: NaN

metaR CYTK13
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (dCMP,dATP)

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR RE0689E
modifier: MODEL1310110018#
fast: false
is: SBO:0000176
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0689
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_71073881_a015_43c5_be6b_249f9237510b
initial amount: NaN
is: Q9BRC7
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:84812
type: Species
boundary condition: true
name: PLCD4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_dded3e78_0870_4b04_88c9_113e1a5d12ae
is encoded by: hsa:55350
initial concentration: NaN
name: VNN3
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_3f117b29_f09e_4b65_96d7_9eb1c099a58d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10400
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: PEMT
initial amount: NaN

metaM thf m
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false
type: Species
is: HMDB01846
constant: false
has only substance units: false
is: C00101
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_fb5245a4_6da7_4f4e_a3f6_420084310780
is encoded by: hsa:7296
type: Species
is: SBO:0000252
boundary condition: true
name: TXNRD1
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR D3AIBTm
reactant: MODEL1310110018#
reversible: true
fast: false
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR HMGLm
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
product: MODEL1310110018#
reversible: false
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
name: hydroxymethylglutaryl-CoA lyase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_ea618122_6bb1_4660_8579_871aa2504bd0
type: Species
is: SBO:0000252
constant: false
name: SPTLC1
initial amount: NaN
boundary condition: true
is encoded by: hsa:10558
initial concentration: NaN
has only substance units: false
is: O15269

http://identifiers.org/biomodels.db/MODEL1310110018#_6888ae8d_9ea1_47ca_9b7a_d4eb1bca285d
is encoded by: hsa:8525
is: SBO:0000252
type: Species
is: B7Z2M9
initial amount: NaN
boundary condition: true
has only substance units: false
name: DGKZ
initial concentration: NaN
constant: false

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP)
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110018#

metaR PETOHMr hs
is version of: http://identifiers.org/ec-code/2.1.1.17
name: phosphatidylethanolamine N-methyltransferase
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000254
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ

metaR XOLDIOLONEt
is: SBO:0000185
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
name: lipid, flip-flop intracellular transport

metaR ASPTAm
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
name: aspartate transaminase
reactant: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_55ba4ad4_7361_4438_b79c_2bd9beab7846
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: _BE042354_1_m
is encoded by: hsa:BE042354
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_b6585df9_adbe_411d_ae58_8deab38e43c6
initial amount: NaN
is encoded by: hsa:30814
has only substance units: false
is: SBO:0000252
type: Species
is: Q9NZK7
name: PLA2G2E
boundary condition: true
constant: false
initial concentration: NaN

metaM guln c
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:13115
has only substance units: false
is: SBO:0000247
is: HMDB03290
name: L-gulonate

metaR LNELDCCRNt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: false
fast: false
modifier: MODEL1310110018#
type: Reaction
name: transport into the mitochondria (carnitine)
is: SBO:0000185

metaR r0556
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110018#
product: MODEL1310110018#

metaR LSTO1r
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
type: Reaction
fast: false
modifier: MODEL1310110018#
is described by: ECO:0000269
name: Lathosterol oxidase
is version of: http://identifiers.org/ec-code/1.14.21.6
reactant: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: trans-3-decenoyl-CoA
is: CHEBI:57449
has only substance units: false
boundary condition: false
constant: false

metaR FAOXC61C4m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_d919560a_6062_4527_aff7_fb8e36fd22a7
is encoded by: hsa:55753
boundary condition: true
type: Species
is: SBO:0000252
is: Q9ULD0
name: OGDHL
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM 10fthf c
constant: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
is: HMDB00972
is: SBO:0000247
name: 10-Formyltetrahydrofolate
initial amount: NaN
type: Species
boundary condition: false
is: C00234
has only substance units: false

metaM leuktrE4 c
initial concentration: 1.0
is: CHEBI:57462
name: leukotriene E4(1-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR CYTK14
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,UTP)

metaM CE2434 m
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial amount: NaN

metaR AMACR2p
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.1.99.4
reactant: MODEL1310110018#
reversible: false
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110018#
name: alpha-methylacyl-CoA racemase (reductase)
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
fast: false

metaM lnlncgcoa r
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06368
boundary condition: false
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
constant: false
type: Species
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaR MI13PP
is: SBO:0000176
name: inositol-1,3-bisphosphate 3-phosphatase
reactant: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110018#

metaR XYLTt
reversible: true
product: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
name: Xylitol transport via passive diffusion
fast: false
type: Reaction

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR r1661
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110018#
type: Reaction

metaM 34dhoxpeg c
initial concentration: 1.0
constant: false
is: C05576
is: http://identifiers.org/pubchem.compound/7902
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00318
type: Species
is: SBO:0000247
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
name: 3,4-Dihydroxyphenylethyleneglycol

metaR r1380
type: Reaction
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
product: MODEL1310110018#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110018#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR RE1897C
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110018#
name: RE1897
type: Reaction
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR FAOXC102C101m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR r1660
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#

metaM HC02214 e
boundary condition: false
constant: false
name: prostaglandin-f1alpha
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial concentration: 1.0
is: SBO:0000247

metaM eaflatoxin c
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
is: CHEBI:30725
has only substance units: false
constant: false
is: HMDB06558
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: aflatoxin B1 exo-8,9-epoxide
initial amount: NaN

metaR r2395
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
kinetic law: MODEL1310110018#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110018#_747fa73c_c6f0_4327_ad80_661afa680803
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6716
constant: false
boundary condition: true
name: SRD5A2
initial concentration: NaN
is: P31213

metaR DHORTS
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
modifier: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is described by: ECO:0000269
name: dihydroorotase
fast: false
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#

metaM andrstandn r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00899
is: SBO:0000247
has only substance units: false
is: CHEBI:15994
initial amount: NaN
constant: false
name: 5alpha-androstane-3,17-dione

metaR r0853
reactant: MODEL1310110018#
reversible: false
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
is: SBO:0000247
is: CHEBI:15748
initial amount: NaN
type: Species
is: HMDB00127
boundary condition: false
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_95cd23c9_8d1f_45af_a88b_ba0d8744b17a
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:83549
is: Q5JT09
name: UCK1
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_fa8118e0_56a8_4d7c_acc5_861b3c001902
name: ST3GAL3
constant: false
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR SPMS
reversible: false
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
name: spermidine synthase
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.5.1.16
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM 34dhoxpeg e
is: SBO:0000247
type: Species
is: HMDB00318
initial concentration: 1.0
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: http://identifiers.org/pubchem.compound/7902
constant: false
name: 3,4-Dihydroxyphenylethyleneglycol
is: C05576
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_041e5804_76eb_4126_ae09_1f7e5d5db05a
has only substance units: false
name: COX7A2
is: SBO:0000252
is encoded by: hsa:1347
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: H0UI06

http://identifiers.org/biomodels.db/MODEL1310110018#_047b8b42_b495_4b7e_8ddf_fcd832dba6c0
constant: false
boundary condition: true
is: B4DKS0
is: SBO:0000252
is encoded by: hsa:6566
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC16A1

http://identifiers.org/biomodels.db/MODEL1310110018#_6b76f471_591f_4fa7_a9dc_ae800f6c973f
name: ADH7
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P40394
constant: false
is encoded by: hsa:131
has only substance units: false
boundary condition: true

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_57fdc7d0_688e_4eaa_bda3_011bd87d30a5
initial amount: NaN
is: P52788
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6611
type: Species
boundary condition: true
is: SBO:0000252
name: SMS

http://identifiers.org/biomodels.db/MODEL1310110018#_d1db2ae6_bf7c_4e00_a6b1_6735708c7a47
type: Species
constant: false
has only substance units: false
is: Q9UNA3
initial amount: NaN
boundary condition: true
name: A4GNT
initial concentration: NaN
is encoded by: hsa:51146
is: SBO:0000252

metaM ksii core2 deg4 l
is: HMDB00812
name: keratan sulfate II (core 2-linked), degradation product 4
type: Species
is: CHEBI:16953
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR XYLtly
is described by: ECO:0000000
is: SBO:0000185
name: Xylose efflux from lysosome
reversible: false
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_eb84299c_7554_4ebb_a23b_e92828c78d5f
is encoded by: hsa:476
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: B7Z3U6
boundary condition: true
is: SBO:0000252
name: ATP1A1
constant: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_e83fae89_de46_4d04_97e6_6263e12eab83
has only substance units: false
constant: false
is encoded by: hsa:2180
boundary condition: true
name: ACSL1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P33121
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_967d8900_0bf4_456b_bf93_d6b54bcf943a
is: O94788
name: ALDH1A2
initial amount: NaN
is encoded by: hsa:8854
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR XYLUR
reversible: true
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.10
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: xylulose reductase
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_79792d4b_aadc_465e_b6e6_7e2d80af471b
name: SLC7A2
type: Species
is: P52569
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6542
initial amount: NaN

metaM 3ohdcoa x
initial amount: NaN
has only substance units: false
is: CHEBI:57349
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
boundary condition: false

metaR r0552
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_40c6f845_5a9e_452b_80b4_66492fd107fd
initial amount: NaN
is encoded by: hsa:1629
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P11182
boundary condition: true
constant: false
name: DBT

metaR r1381
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110018#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
kinetic law: MODEL1310110018#

metaR TETTET6COAtx
product: MODEL1310110018#
name: fatty acid intracellular transport
reversible: true
kinetic law: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reactant: MODEL1310110018#

metaR ARACHDtr
is described by: ECO:0000000
product: MODEL1310110018#
reversible: true
is: SBO:0000185
name: intracellular transport
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction

metaM HC02214 c
name: prostaglandin-f1alpha
is: CHEBI:28852
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_470c5eb1_ac8c_4379_9bc2_685145d2c267
initial concentration: NaN
name: ATP1B1
boundary condition: true
constant: false
is encoded by: hsa:481
initial amount: NaN
has only substance units: false
type: Species
is: A3KLL5
is: SBO:0000252

metaR HISD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is described by: ECO:0000269
reversible: false
product: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.3
reactant: MODEL1310110018#
name: histidase

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
is: CHEBI:57336
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01041
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
type: Species

metaR PRGNLONEtm
name: pregnenolone intracellular transport
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110018#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110018#
reversible: true

metaR GARFT
type: Reaction
name: phosphoribosylglycinamide formyltransferase
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110018#_5e8a651c_4f13_403a_96f4_cbfed719e5ee
is: P54750
is encoded by: hsa:5136
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: PDE1A

metaR r2369
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110018#
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR DOLPMT4 Uer
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110018#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_5918657f_7cc3_4e0e_9f66_04736098e3d4
name: ALDH1A1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:216
is: P00352
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR RE0453M
name: RE0453
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR r0871
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
kinetic law: MODEL1310110018#
reversible: true
is described by: ECO:0000000
type: Reaction
name: Diffusion
fast: false

metaR MG2er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
reactant: MODEL1310110018#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110018#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#

metaM hdd2coa c
type: Species
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: C05272
has only substance units: false
is: CHEBI:61526

metaR BETALDHxm
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
is described by: ECO:0000000
name: betaine-aldehyde dehydrogenase, mitochondrial
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: false
type: Reaction
is: SBO:0000176

metaM chlstol r
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: CHEBI:16290
is: HMDB06842
type: Species
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaR S6T2g
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000176
reactant: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r0559
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

metaR r0870
is version of: http://identifiers.org/ec-code/2.7.7.72
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Facilitated diffusion
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.4
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110018#

metaM ethamp c
constant: false
type: Species
is: CHEBI:58190
boundary condition: false
name: ethamp[c]
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
is: HMDB00224

http://identifiers.org/biomodels.db/MODEL1310110018#_6837ab68_6db1_44ac_94f4_7129a3499318
initial amount: NaN
type: Species
name: FH
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2271
is: P07954
constant: false
initial concentration: NaN

metaM q10 c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB01072
name: ubiquinone-10
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
is: CHEBI:46245
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_cafdad90_5213_4c9d_9dbf_95918bed2e3f
name: UGT1A8
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:54576
type: Species
initial concentration: NaN
is: Q5DSZ6
initial amount: NaN
has only substance units: false

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_2f95d32e_0f92_48d4_9844_da8eb7c46390
is: SBO:0000252
constant: false
is encoded by: hsa:114134
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC2A13
type: Species
is: Q96QE2
initial concentration: NaN

metaR r0558
modifier: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaM occoa m
constant: false
is: SBO:0000247
is: C01944
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: CHEBI:57386
type: Species
has only substance units: false
initial concentration: 1.0

metaR r2367
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_6da6a0ea_abae_49b7_b1ef_8136dec38948
is encoded by: hsa:8050
initial amount: NaN
is: O00330
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PDHX
initial concentration: NaN

metaR r0130
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
is described by: ECO:0000000

metaR UDPtl
fast: false
name: udp intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
type: Reaction
reactant: MODEL1310110018#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#

metaM ksi deg37 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 37
notes: FORMULA: C62H104N4O46 CHARGE: 0
constant: false
type: Species
is: HMDB00812
boundary condition: false
is: CHEBI:16953
initial amount: NaN

metaR AG13T9g
fast: false
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110018#

metaM atp x
boundary condition: false
name: ATP(4-)
constant: false
is: HMDB00538
initial amount: NaN
has only substance units: false
is: CHEBI:57299
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00002

metaM Rtotal3coa c
is: HMDB01448
type: Species
name: R total 3 Coenzyme A
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16189
initial concentration: 1.0

metaR RE1516M
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
product: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1516
reactant: MODEL1310110018#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r2368
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaM odecoa c
is: SBO:0000247
has only substance units: false
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
is: CHEBI:3793
type: Species
initial concentration: 1.0
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false

metaM 2mp2coa m
is: SBO:0000247
constant: false
name: 2-Methylprop-2-enoyl-CoA
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
is: HMDB01011
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_dac13733_6f56_4c24_a85e_c75cd5528c8a
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2687
name: GGT5
type: Species
constant: false
is: P36269
boundary condition: true

metaM dlnlcg c
is: CHEBI:53486
type: Species
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02925

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_d16b0266_0e9c_4d10_add2_89975ad3321d
name: SLC27A1
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q6PCB7
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:376497

metaR ACGAMPM
reversible: true
name: phosphoacetylglucosamine mutase
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is: SBO:0000176
product: MODEL1310110018#
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_63be69aa_fb50_4d29_8977_08a5c640d3af
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AW299740
initial concentration: NaN
name: _AW299740_1_m
initial amount: NaN
boundary condition: true

metaR DASPO1p
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
type: Reaction
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.1
reversible: false
name: D-aspartate oxidase, peroxisomal
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
is described by: ECO:0000269

metaR 4HOXPACDOX NADP
type: Reaction
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000304
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR DHCR243r
is described by: ECO:0000134
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110018#
type: Reaction

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM q10 e
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
is: SBO:0000247
type: Species
initial amount: NaN
name: ubiquinone-10
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

metaM HC01115 c
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: NeuNGc
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:29025
constant: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

http://identifiers.org/biomodels.db/MODEL1310110018#_640598c7_a25e_40dd_a837_b0d96838e13a
initial concentration: NaN
is: SBO:0000252
is: P19971
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1890
name: TYMP
has only substance units: false

metaR ME2m
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
kinetic law: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
name: malic enzyme (NADP), mitochondrial
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.40
is version of: http://identifiers.org/ec-code/1.1.1.38

http://identifiers.org/biomodels.db/MODEL1310110018#_2b3a46c7_6aaa_470d_bee2_f999914cf341
initial amount: NaN
is: Q6LEN5
is encoded by: hsa:1103
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CHAT
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_95f903d7_503d_4d4f_a561_7b317d45191e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3141
initial amount: NaN
name: HLCS
type: Species
constant: false
boundary condition: true
is: P50747
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ccea99e1_b2b9_4777_8bf9_ff8457d524fb
has only substance units: false
name: CMAS
is encoded by: hsa:55907
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q8NFW8
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_ce1b05a6_103e_40c1_8c52_f34488980834
is: Q9BV79
name: MECR
is encoded by: hsa:51102
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaR ABTti
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_c6c4b1e8_1daf_4f25_a322_f7d96f5a1254
is encoded by: hsa:953
initial amount: NaN
constant: false
is: Q86VV3
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: ENTPD1

metaR ADRNCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true

metaM dcholcoa r
initial concentration: 1.0
is: HMDB06292
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
type: Species
name: chenodeoxycholoyl coenzyme a
has only substance units: false

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
name: Aminobutyraldehyde dehydrogenase
product: MODEL1310110018#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110018#
fast: false
type: Reaction

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
modifier: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_271573c6_d8d5_464f_9be5_1abaf77d6744
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:115584
boundary condition: true
type: Species
is: Q8WWX8
initial amount: NaN
name: SLC5A11
initial concentration: NaN

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: pentaglutamyl folate (DHF)
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06487

metaR FAOXC142C122m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM acngalgbside hs g
initial amount: NaN
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16523
constant: false
is: HMDB03406
initial concentration: 1.0
is: SBO:0000247

metaM mthgxl e
is: HMDB01167
initial concentration: 1.0
is: SBO:0000247
name: methylglyoxal
is: CHEBI:17158
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
initial amount: NaN

metaM atp r
is: CHEBI:57299
constant: false
name: ATP(4-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00538
initial amount: NaN
boundary condition: false
type: Species
is: C00002

http://identifiers.org/biomodels.db/MODEL1310110018#_94c47531_3159_4b94_9664_08734f7cb1bd
is: SBO:0000252
boundary condition: true
is: Q9BVK2
type: Species
has only substance units: false
is encoded by: hsa:79053
name: ALG8
constant: false
initial amount: NaN
initial concentration: NaN

metaM HC01104 e
boundary condition: false
has only substance units: false
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:61146
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_c4df004e_ef27_491a_b699_79732fc42c99
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: HMOX2
constant: false
is: P30519
is encoded by: hsa:3163
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_e537ffb9_d598_4921_9681_91cb5994542f
is: P23743
is encoded by: hsa:1606
initial amount: NaN
name: DGKA
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9f817733_00d7_4987_946f_941e55d826d0
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: NME1:NME2
initial concentration: NaN
is encoded by: hsa:4830

metaM glyc c
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17754
initial amount: NaN
is: C00116
is: SBO:0000247
name: Glycerol
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false

metaM mhista c
constant: false
has only substance units: false
is: HMDB00898
is: SBO:0000247
is: CHEBI:58600
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
name: N(tele)-methylhistaminium
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_f35d1f78_1ba6_4ec6_8436_7ad0a65fef2e
has only substance units: false
constant: false
type: Species
is: Q9UKG4
name: SLC13A4
is encoded by: hsa:26266
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM btn m
has only substance units: false
is: CHEBI:57586
initial amount: NaN
type: Species
name: biotinate
initial concentration: 1.0
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_06ce50fa_a24d_460c_b540_6756f318e60b
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:55902
is: Q5QPH3
has only substance units: false
boundary condition: true
name: ACSS2

http://identifiers.org/biomodels.db/MODEL1310110018#_d6568b17_aa45_49f7_a591_ac581c918261
initial amount: NaN
has only substance units: false
is encoded by: hsa:8309
constant: false
is: Q99424
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACOX2

metaR RE3245C
product: MODEL1310110018#
type: Reaction
name: RE3245
kinetic law: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110018#
fast: false
is: SBO:0000176

metaR S2TASE3ly
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.13
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110018#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR B3GALT5g
modifier: MODEL1310110018#
reactant: MODEL1310110018#
name: Beta-1,3-galactosyltransferase 5
fast: false
product: MODEL1310110018#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110018#

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
is described by: ECO:0000269
product: MODEL1310110018#
type: Reaction

metaR FAOXC101C102m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r0409
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.10
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM dcsptn1crn m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
is: HMDB06321

metaM mthgxl c
name: methylglyoxal
initial concentration: 1.0
has only substance units: false
is: HMDB01167
is: SBO:0000247
boundary condition: false
is: CHEBI:17158
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
constant: false
initial amount: NaN

metaR SADT
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110018#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000176
name: sulfate adenylyltransferase
type: Reaction

metaM ha l
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
name: hyaluronan
is: CHEBI:16336

metaM ksii core2 deg8 l
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:12936
initial amount: NaN
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: HMDB00143
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 8
has only substance units: false

metaR RE0453N
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110018#
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_1c527738_129f_47e9_b35a_d0f5b802ea03
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:206
is: SBO:0000252
has only substance units: false
name: _206_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_b876c43d_973b_4249_81b6_099cf422da21
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ENTPD3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:956
is: O75355

metaR r0408
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
fast: false

metaR FAOXC164C165m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM glyc e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17754
is: C00116
constant: false
type: Species
name: Glycerol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
is: HMDB00131

metaM inost e
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
type: Species
is: CHEBI:17268
name: myo-inositol
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r0407
kinetic law: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is: SBO:0000176
reactant: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction

metaR 5ADTSTSTERONEtr
is: SBO:0000185
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
kinetic law: MODEL1310110018#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110018#_7131c151_c744_4632_aae8_6277e51ed1d9
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ADCY5
is encoded by: hsa:111
constant: false
initial amount: NaN
is: O95622
initial concentration: NaN
type: Species

metaM occoa x
initial amount: NaN
is: HMDB01070
type: Species
is: CHEBI:57386
constant: false
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
is: C01944
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247

metaM dutp n
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01191
type: Species
boundary condition: false
is: CHEBI:17625
initial concentration: 1.0
name: dUTP

metaM mma c
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
initial amount: NaN
is: HMDB00164
constant: false
type: Species
is: CHEBI:59338
is: SBO:0000247
name: methylammonium

http://identifiers.org/biomodels.db/MODEL1310110018#_8e4cfec0_a75f_4711_ae67_a9eb128911e8
initial concentration: NaN
name: PDE9A
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:5152
type: Species

metaM prostge1 c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01442
name: prostaglandin E1(1-)
is: CHEBI:57397
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_48a7a805_aedf_4f70_b461_fd886a5c1d93
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AA502753_1_m
initial amount: NaN
is encoded by: hsa:AA502753
is: SBO:0000252

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_34caac65_aee9_4d7b_a7cd_bae30a99232a
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6184
initial concentration: NaN
has only substance units: false
is: P04843
name: RPN1
initial amount: NaN
boundary condition: true

metaM gsn c
is: CHEBI:16750
type: Species
is: HMDB00133
constant: false
boundary condition: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
is: C00387
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Guanosine

metaR MG3er
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: false
type: Reaction
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
fast: false
kinetic law: MODEL1310110018#

metaM lgnc c
initial amount: NaN
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false
constant: false
is: HMDB02003
name: lignocerate
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110018#_c0f33039_bf78_4569_8bfb_56d66eb90c1d
is encoded by: hsa:8789
initial concentration: NaN
is: O00757
has only substance units: false
initial amount: NaN
name: FBP2
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_7cf8ebec_73cd_48e2_b55a_700f0abec48f
name: NDUFB1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4707
initial amount: NaN
is: O75438

metaR B MANNASEly
fast: false
name: beta-mannosidase, lysosomal
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
modifier: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25
kinetic law: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#

metaR METtec
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)
product: MODEL1310110018#
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB

metaR PI34P5K
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176

metaR PI45PLC
fast: false
is: SBO:0000176
kinetic law: MODEL1310110018#
is described by: ECO:0000000
reactant: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110018#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110018#
type: Reaction

metaR r0139
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#

metaR LGNCCOAtx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
name: fatty acid intracellular transport
reactant: MODEL1310110018#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR ACGAMK
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
name: N-acetylglucosamine kinase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
reversible: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_1061bdb1_920e_4054_9b7d_d69c67095a75
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5297
name: PI4KA
is: B4DYG5
initial concentration: NaN
is: SBO:0000252

metaM g6p c
is: C00092
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
has only substance units: false
is: CHEBI:61548
type: Species

metaR RE0453C
kinetic law: MODEL1310110018#
name: RE0453
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110018#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_0ad0160a_0f7b_4fed_9b56_aaff0b0ffb16
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1491
has only substance units: false
is: P32929
is: SBO:0000252
type: Species
name: CTH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110018#_3da745bd_a892_4ba9_95c3_623b490bd6d3
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:196883
name: ADCY4
boundary condition: true
is: SBO:0000252
is: Q8NFM4
initial concentration: NaN

metaR UGALNACtg
fast: false
modifier: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110018#_2d99046f_21e4_4636_b523_c107ef03cc9b
is encoded by: hsa:5092
constant: false
initial amount: NaN
has only substance units: false
name: PCBD1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaM gd3 hs g
is: CHEBI:28424
name: GD3
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR HPACtr
product: MODEL1310110018#
kinetic law: MODEL1310110018#
type: Reaction
name: hydroxyphenylacetate transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reactant: MODEL1310110018#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM prostge1 e
initial amount: NaN
is: HMDB01442
initial concentration: 1.0
is: CHEBI:57397
is: SBO:0000247
has only substance units: false
name: prostaglandin E1(1-)
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
constant: false

metaR r2088
fast: false
modifier: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_60e62049_cf0a_4075_98b6_867410106646
constant: false
initial concentration: NaN
name: GBA
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:2629
is: B7Z6S1

metaR GGH 10FTHF6GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
modifier: MODEL1310110018#
type: Reaction
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is described by: ECO:0000000
reactant: MODEL1310110018#

metaR FAOXC121x
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_ecbb8e6b_a376_4851_932e_c5dae1a08126
is encoded by: hsa:HG2846-HT2983
type: Species
has only substance units: false
boundary condition: true
name: _HG2846_HT2983_1_m
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR ACOX22x
reversible: false
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
fast: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.99.3
name: acyl-Coenzyme A oxidase 2, branched chain

metaM lgnc e
type: Species
is: SBO:0000247
is: CHEBI:31014
constant: false
has only substance units: false
name: lignocerate
is: HMDB02003
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547

metaR DCYTt
name: deoxycytidine transport via diffusion
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185

metaM ocdca c
name: stearate
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
constant: false
initial amount: NaN
is: HMDB00827
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:25629
initial concentration: 1.0

metaR FACOAL2042
type: Reaction
modifier: MODEL1310110018#
name: fatty-acid--CoA ligase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR LEUKTRB4t
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
reactant: MODEL1310110018#
name: leukotriene B4 transport

metaR r2089
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110018#_3da9a4da_a66a_47eb_8429_cedbdb0aad41
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8528
name: DDO
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_289b42b6_c3fe_4987_8a3a_134103117cee
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2629
name: GBA
is: B7Z5G2

http://identifiers.org/biomodels.db/MODEL1310110018#_1c70e773_555b_42e6_824b_9558876a1254
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ATG9B
boundary condition: true
is encoded by: hsa:285973
is: Q674R7
is: SBO:0000252
constant: false

metaM cysam c
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: cysteaminium
is: HMDB02991
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029

http://identifiers.org/biomodels.db/MODEL1310110018#_3caab63b_fbfb_4331_9da0_69248bb00432
initial concentration: NaN
name: PKM2
boundary condition: true
is: P14618
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5315

metaM tchola c
initial amount: NaN
name: taurocholic acid
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36257
has only substance units: false
constant: false

metaR r2086
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110018#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#

metaR r0281
fast: false
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110018#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6

metaR r0403
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110018#
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_a2337896_3f93_42b3_aaca_0e497c85f31e
type: Species
is: SBO:0000252
boundary condition: true
name: _AI824319_1_r
is encoded by: hsa:AI824319
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_793cc356_75d1_4750_8c64_162e83338fd4
type: Species
is: SBO:0000252
name: CYP27A1
initial amount: NaN
is: Q02318
constant: false
has only substance units: false
is encoded by: hsa:1593
boundary condition: true
initial concentration: NaN

metaR CYTK11n
name: cytidylate kinase (dCMP,dGTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110018#
type: Reaction
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000269
reversible: true

metaM 5mta c
is: SBO:0000247
name: 5-Methylthioadenosine
type: Species
is: HMDB01173
initial concentration: 1.0
is: C00170
initial amount: NaN
has only substance units: false
is: CHEBI:17509
boundary condition: false
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170

metaM btn e
is: C00120
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:3420
is: HMDB00030
constant: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR r0707
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
reversible: true
is: SBO:0000176
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.3.1.168
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR r2087
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110018#
is: SBO:0000185
fast: false
reversible: true

metaR PDE4n
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
reversible: false
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
type: Reaction
reactant: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269

metaM psyl e
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
initial amount: NaN
constant: false
name: psyllium

metaR FADtx
name: FAD transporter, peroxisomal
is: SBO:0000185
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false

metaR ASPDTDe
name: D-aspartate transport, extracellular
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
product: MODEL1310110018#
reversible: true
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
type: Reaction

metaM thcrm hs g
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
is: CHEBI:24636
name: trihexosyl ceramide
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_56b197e1_333a_4aab_8059_314efcfe8f86
initial concentration: NaN
name: PLA2G10
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: O15496
is encoded by: hsa:8399
constant: false
initial amount: NaN

metaR G14T3g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
modifier: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_f9517336_1c6b_484a_818c_0c060a80a0a2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5019
is: P55809
type: Species
initial amount: NaN
is: SBO:0000252
name: OXCT1
boundary condition: true
constant: false

metaR URAt
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: uracil transport via facilated diffusion
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110018#

metaR S6TASE13ly
modifier: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR r2083
modifier: MODEL1310110018#
fast: false
reversible: true
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NTD2m
reactant: MODEL1310110018#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110018#
is: SBO:0000176
name: 5'-nucleotidase (UMP), mitochondrial
reversible: false
type: Reaction
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
modifier: MODEL1310110018#

metaM ksi deg17 l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 17
constant: false
initial amount: NaN
type: Species
is: CHEBI:12936
has only substance units: false

metaM m6masnB2 g
initial amount: NaN
has only substance units: false
is: HMDB00573
initial concentration: 1.0
is: CHEBI:30825
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
constant: false
type: Species

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110018#
reactant: MODEL1310110018#

metaM ppcoa x
initial concentration: 1.0
is: CHEBI:57392
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Propanoyl-CoA
constant: false
is: HMDB01275
boundary condition: false
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species

metaM dcholcoa x
initial concentration: 1.0
has only substance units: false
constant: false
name: chenodeoxycholoyl coenzyme a
type: Species
is: CHEBI:28701
boundary condition: false
initial amount: NaN
is: HMDB06292
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaM udpglcur c
constant: false
type: Species
initial amount: NaN
name: UDP-D-glucuronate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
is: HMDB00935
has only substance units: false
is: SBO:0000247
is: CHEBI:58052

http://identifiers.org/biomodels.db/MODEL1310110018#_84e28782_7a31_4c62_950b_d7fa27dbb61a
initial concentration: NaN
initial amount: NaN
name: HMBS
is: P08397
has only substance units: false
constant: false
type: Species
is encoded by: hsa:3145
boundary condition: true
is: SBO:0000252

metaM dutp m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17625
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
type: Species

metaM glyc m
type: Species
constant: false
is: CHEBI:17754
has only substance units: false
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Glycerol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_dabe7473_4a75_48d2_82b1_1e70c3aceef6
name: RPIA
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P49247
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:22934

http://identifiers.org/biomodels.db/MODEL1310110018#_21594b6f_3bac_4159_a341_35c8e7537b6e
has only substance units: false
name: _AI291895_1_c
constant: false
is: SBO:0000252
is encoded by: hsa:AI291895
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_5724a3af_8cb5_4652_aa21_2f39fc45a4e4
boundary condition: true
has only substance units: false
is encoded by: hsa:4706
name: NDUFAB1
constant: false
is: O14561
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR CDPDAGtm
fast: false
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport

metaM inost c
is: HMDB00211
has only substance units: false
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
constant: false
name: myo-inositol
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM f26bp c
type: Species
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
is: CHEBI:58579
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01047
constant: false
boundary condition: false

metaM tchola e
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
constant: false
name: taurocholic acid
is: SBO:0000247
boundary condition: false

metaR r2085
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
reversible: true
fast: false

metaM clpndcoa c
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: C16166
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205476
is: HMDB06267
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: clupanodonyl CoA

metaR r0400
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
fast: false
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110018#
type: Reaction
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110018#

metaM acmanap c
initial amount: NaN
is: SBO:0000247
is: HMDB01121
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial concentration: 1.0
constant: false
type: Species
name: N-acetyl-D-mannosamine 6-phosphate(2-)
boundary condition: false
is: CHEBI:58557

metaR SMPD4
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
type: Reaction
name: sphingomyelinase
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000000

metaM btn c
is: SBO:0000247
is: CHEBI:3420
boundary condition: false
name: Biotin
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
initial amount: NaN
is: HMDB00030
has only substance units: false
constant: false
is: C00120

http://identifiers.org/biomodels.db/MODEL1310110018#_73a8c8b4_622e_4f7c_a88b_01134c0e8c6f
type: Species
initial concentration: NaN
initial amount: NaN
name: DCTD
is: P32321
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1635
boundary condition: true

metaM Tn antigen g
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Tn antigen
has only substance units: false
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110018#_d0d5ad0e_edb8_4603_9ed5_a2cde0626f6d
is: P19174
is encoded by: hsa:5335
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PLCG1
boundary condition: true

metaR APAT2rm
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110018#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
modifier: MODEL1310110018#
reversible: true
type: Reaction
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
reactant: MODEL1310110018#
is described by: ECO:0000212

metaR 34DHPHEt
type: Reaction
name: 3,4-Dihydroxy-L-phenylalanine transport
product: MODEL1310110018#
reversible: true
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD

metaR KSII CORE2t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction

metaM hcys L c
is: HMDB00742
is: CHEBI:17588
constant: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
name: L-homocysteine
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_dc36e925_4129_49a9_b4e2_362c066e850d
initial amount: NaN
is encoded by: hsa:1892
is: SBO:0000252
type: Species
boundary condition: true
is: P30084
name: ECHS1
constant: false
has only substance units: false
initial concentration: NaN

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
fast: false
is described by: ECO:0000000
product: MODEL1310110018#
is: SBO:0000176
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110018#
type: Reaction
reversible: true

metaR r2095
is: SBO:0000185
modifier: MODEL1310110018#
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM ksi deg32 l
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial amount: NaN
name: keratan sulfate I, degradation product 32
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
type: Species
is: HMDB00143
constant: false
has only substance units: false

metaR PCHOLP hs
modifier: MODEL1310110018#
is described by: ECO:0000269
reactant: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
name: choline phosphatase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false

metaR r2094
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX 34hpp
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR DM dttp m
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_84fa93e4_8da0_4480_9add_ccf3cd865191
initial concentration: NaN
name: RHAG
type: Species
is: Q96E98
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6005

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM met L c
initial concentration: 1.0
name: L-methionine
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00696
is: CHEBI:16643
boundary condition: false
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

metaM succoa m
constant: false
is: CHEBI:57292
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
name: Succinyl-CoA
boundary condition: false
is: HMDB01022

metaM prpp e
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
is: CHEBI:58017
boundary condition: false
constant: false
is: HMDB00280
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
name: glutamine phosphoribosyldiphosphate amidotransferase
product: MODEL1310110018#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_9020de50_0597_4918_ad9c_b12b466c9627
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5315
constant: false
boundary condition: true
name: PKM2
initial concentration: NaN
has only substance units: false
type: Species

metaM atp e
has only substance units: false
is: CHEBI:57299
initial amount: NaN
constant: false
is: HMDB00538
initial concentration: 1.0
is: C00002
name: ATP(4-)
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_739c6a1b_3b89_49d2_85ed_9e1a19496e73
is: P27707
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: DCK
is encoded by: hsa:1633
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR r1678
kinetic law: MODEL1310110018#
type: Reaction
reversible: false
product: MODEL1310110018#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110018#
is: SBO:0000185

metaR FAOXC164m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM tyr L e
constant: false
has only substance units: false
type: Species
is: CHEBI:17895
is: HMDB00158
initial amount: NaN
name: L-tyrosine
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
boundary condition: false

metaR r2093
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction

metaR PI345P5P
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110018#

metaR S6TASE1ly
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_885ea1f9_dad6_406c_87b7_ca3abb15c11c
initial concentration: NaN
name: NME4
is: O00746
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:4833

http://identifiers.org/biomodels.db/MODEL1310110018#_a5ad654f_037a_4d14_adce_c4d578eb3cc3
has only substance units: false
is encoded by: hsa:3030
initial concentration: NaN
constant: false
boundary condition: true
is: E9KL44
type: Species
is: SBO:0000252
name: HADHA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_e1280481_b9e3_462d_9968_ca53f9f6a0fe
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:248
constant: false
is: P09923
is: SBO:0000252
type: Species
initial amount: NaN
name: ALPI

metaM HC00718 c
type: Species
constant: false
is: CHEBI:57781
has only substance units: false
boundary condition: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
initial amount: NaN
name: N-methylethanolaminium phosphate(1-)
initial concentration: 1.0

metaR ALR3
fast: false
product: MODEL1310110018#
is described by: ECO:0000269
reversible: false
name: aldose reductase (acetol)
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:58190
is: SBO:0000247
boundary condition: false
is: HMDB00224
initial amount: NaN
type: Species
constant: false

metaM clpndcoa x
constant: false
has only substance units: false
type: Species
is: HMDB06267
initial concentration: 1.0
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110018#_ce44e00e_052b_40cb_9458_51e9f8529ba0
has only substance units: false
constant: false
name: HK1
is encoded by: hsa:3098
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q59FD4

metaR AMPtp
fast: false
name: AMP transporter, peroxisome
reversible: true
type: Reaction
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110018#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_75e335d9_1247_40e3_944d_16233ac192f3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: TK2
constant: false
is: O00142
is encoded by: hsa:7084
type: Species
boundary condition: true

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR r2092
kinetic law: MODEL1310110018#
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR ALR2
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110018#
is: SBO:0000176
name: aldose reductase (methylglyoxal)
type: Reaction
is described by: ECO:0000269

metaM nadh c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01487
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945

http://identifiers.org/biomodels.db/MODEL1310110018#_453f7eac_62bf_48b7_a44e_b4ed194b6d15
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10587
name: TXNRD2
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_cc68c5c4_4697_4851_8ecb_c0eae4e61a8e
is: SBO:0000252
has only substance units: false
is: P31939
constant: false
is encoded by: hsa:471
name: ATIC
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaM 5mta e
initial amount: NaN
constant: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 5-Methylthioadenosine
is: CHEBI:17509
is: HMDB01173
is: C00170
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_608b6dba_dfe6_43dd_860f_307d9b6bce76
type: Species
initial concentration: NaN
is: Q96BD0
has only substance units: false
constant: false
boundary condition: true
name: SLCO4A1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:28231

http://identifiers.org/biomodels.db/MODEL1310110018#_85d24c43_ba93_4e18_87f3_e8cec53609b6
is: Q13825
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: AUH
is encoded by: hsa:549
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR PGDI
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110018#
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/5.3.99.2
fast: false
is described by: ECO:0000269
type: Reaction
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110018#

metaR r2091
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110018#
fast: false
reversible: true
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM aflatoxin c
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
is: CHEBI:2504
constant: false
type: Species
has only substance units: false
name: aflatoxin B1
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06552
is: SBO:0000247

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR r0706
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110018#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is: SBO:0000176

metaM tyr L c
has only substance units: false
name: L-tyrosine
constant: false
type: Species
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
initial amount: NaN
is: HMDB00158
is: SBO:0000247
boundary condition: false

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
constant: false
name: proton
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_b802240b_ccfd_4a4a_90a1_8a689411216a
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AW277253
has only substance units: false
is: SBO:0000252
name: _AW277253_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110018#_2654a59c_3992_44e6_9942_ebfa16dc018b
is: SBO:0000252
constant: false
is: Q16795
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4704
initial amount: NaN
name: NDUFA9

http://identifiers.org/biomodels.db/MODEL1310110018#_ed5adafb_210c_462a_98a2_7c5e2803e628
has part: E9PB82
constant: false
has only substance units: false
name: ACAA1:HSD17B4:ACOX1
initial amount: NaN
is encoded by: hsa:3295
boundary condition: true
initial concentration: NaN
is: SBO:0000297
type: Species

metaM hdd2coa x
is: SBO:0000247
is: HMDB03945
constant: false
has only substance units: false
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:61526

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM h m
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: C00080
type: Species
has only substance units: false
initial concentration: 1.0
name: proton
is: CHEBI:24636
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247

metaM C05280 m
initial concentration: 1.0
is: CHEBI:28002
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
is: HMDB03952
is: SBO:0000247
name: cis,cis-3,6-Dodecadienoyl-CoA

metaR DKMPPD
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
type: Reaction
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000176

metaR ORPT
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110018#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: orotate phosphoribosyltransferase
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reversible: true

metaM pre prot r
has only substance units: false
is: SBO:0000247
notes: FORMULA: XY CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03125
constant: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial amount: NaN
is: CHEBI:16240

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
product: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
reactant: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR RE3244R
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
reversible: true
name: RE3244

http://identifiers.org/biomodels.db/MODEL1310110018#_f0e59caa_9a7d_4d71_b4a3_93d5ec3cc74d
has only substance units: false
name: PLA2G1B
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5319
type: Species
constant: false
is: P04054
initial amount: NaN
initial concentration: NaN

metaM dutp c
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: C00460
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01191

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM ppcoa c
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
name: Propanoyl-CoA
is: SBO:0000247
has only substance units: false
is: C00100
type: Species
boundary condition: false
is: HMDB01275
initial amount: NaN
initial concentration: 1.0
constant: false

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: true
product: MODEL1310110018#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR TAUBETAtc
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaR S6T11g
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reversible: false
is: SBO:0000176
product: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_40199558_c72e_4df8_b658_035c1c69485f
has only substance units: false
name: PRDX2
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:7001
initial amount: NaN
boundary condition: true

metaM dcholcoa c
boundary condition: false
is: CHEBI:28701
initial amount: NaN
constant: false
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
is: SBO:0000247
is: HMDB06292
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_718c7539_0377_4315_9c5e_ccd833540356
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3635
initial concentration: NaN
initial amount: NaN
is: Q92835
constant: false
name: INPP5D

metaR r1116
is: SBO:0000185
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
reactant: MODEL1310110018#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
kinetic law: MODEL1310110018#
is described by: ECO:0000000
product: MODEL1310110018#

metaR FE2tm
kinetic law: MODEL1310110018#
name: iron (II) transport
type: Reaction
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
is: SBO:0000185
reactant: MODEL1310110018#
fast: false

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM dhcholestanate c
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0560
reactant: MODEL1310110018#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110018#
is described by: ECO:0000000
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110018#
fast: false

metaM h n
boundary condition: false
constant: false
is: SBO:0000247
name: proton
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110018#_0d8d344b_0b55_4097_8e11_505cba29a477
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM alpam m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: S-aminomethyldihydrolipoamide
boundary condition: false
is: HMDB06239
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)

metaM HC02179 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:34306
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR APOC LYS BTNP
name: proteolysis of apoC-Lys-btn
reversible: false
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_fe4e80fa_9878_4e60_ad37_8884c2126717
is encoded by: hsa:6648
is: P04179
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: SOD2
initial concentration: NaN
is: SBO:0000252

metaR A MANASEly
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
modifier: MODEL1310110018#
reactant: MODEL1310110018#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.24
is: SBO:0000176
is described by: ECO:0000000
name: alpha-mannosidase, lysosomal
type: Reaction
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_9f050a00_78ea_457e_81f7_efeb762ec933
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4247
constant: false
type: Species
is: Q10469
has only substance units: false
is: SBO:0000252
name: MGAT2
boundary condition: true

metaR r1677
modifier: MODEL1310110018#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110018#
product: MODEL1310110018#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaM gncore2 g
constant: false
initial amount: NaN
notes: FORMULA: C30H50N3O20X CHARGE: 0
name: GlcNAc-alpha-1,4-Core 2
has only substance units: false
boundary condition: false
is: CHEBI:15876
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM ksi deg21 l
constant: false
is: CHEBI:12936
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
type: Species
name: keratan sulfate I, degradation product 21
is: HMDB00143
initial amount: NaN

metaM prpp c
name: 5-Phospho-alpha-D-ribose 1-diphosphate
boundary condition: false
type: Species
is: C00119
has only substance units: false
is: CHEBI:58017
constant: false
is: SBO:0000247
is: HMDB00280
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0

metaR S6TASE23ly
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
fast: false

metaR r0973
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110018#
name: Facilitated diffusion
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_0deb6442_3fb1_4b15_8145_c2db0f28c189
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: UPP1
is: SBO:0000252
is encoded by: hsa:7378

http://identifiers.org/biomodels.db/MODEL1310110018#_9e4b1887_863f_4ae1_87e2_51910809d7bb
name: MAOB
is: P27338
has only substance units: false
is encoded by: hsa:4129
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR DLNLCGt
reactant: MODEL1310110018#
reversible: true
kinetic law: MODEL1310110018#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: fatty acid transport via diffusion
is described by: ECO:0000000
product: MODEL1310110018#

metaR GluForTx
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.5
name: Glutamate formimidoyltransferase
product: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
reversible: false
kinetic law: MODEL1310110018#

metaR FAOXC16DCr
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_7c64f837_2663_4396_acde_b4800b704330
is encoded by: hsa:51733
boundary condition: true
is: B3KNC1
has only substance units: false
is: SBO:0000252
name: UPB1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110018#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110018#
product: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#

metaR NACHEX19ly
reversible: false
modifier: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110018#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110018#_e57543ce_56f9_456d_b74e_bb577f537fb7
is: P23919
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DTYMK
is encoded by: hsa:1841
boundary condition: true
constant: false
type: Species

metaM atp c
initial concentration: 1.0
type: Species
initial amount: NaN
name: ATP(4-)
constant: false
is: HMDB00538
boundary condition: false
is: C00002
is: SBO:0000247
is: CHEBI:30616
has only substance units: false

metaR SO4OXAtex2
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110018#
modifier: MODEL1310110018#
name: sulfate transport via oxalate countertransport (2:1)
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110018#
reversible: false

metaM h l
name: proton
is: CHEBI:24636
is: C00080
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7615882c_64ca_43f3_a181_4a25f3f65cc0
name: B3GNT8
is encoded by: hsa:374907
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_4ecd6343_2f8a_45d1_bfd5_eadb3a7f777c
constant: false
initial amount: NaN
type: Species
name: _AI684467_1_m
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI684467
has only substance units: false

metaR r0974
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
fast: false
name: Active transport
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_62ad2f28_681d_4772_8fa4_1e0958ac17e6
initial concentration: NaN
is: O60503
is encoded by: hsa:115
boundary condition: true
type: Species
name: ADCY9
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_5734cb17_3b37_4b92_bd32_db1890343427
has only substance units: false
name: B3GNT6
is: SBO:0000252
type: Species
is encoded by: hsa:192134
initial concentration: NaN
initial amount: NaN
constant: false
is: A8K9Q8
boundary condition: true

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR GGH 10FTHF7GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
type: Reaction
kinetic law: MODEL1310110018#
fast: false
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular

metaR CYTK2n
is: SBO:0000176
reversible: true
product: MODEL1310110018#
name: cytidylate kinase (dCMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110018#

metaR PYDAMK
is version of: http://identifiers.org/ec-code/2.7.1.35
name: pyridoxamine kinase
type: Reaction
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is described by: ECO:0000269
modifier: MODEL1310110018#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110018#_9c3b917b_5989_4241_bc52_e7a6964bce01
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: PPAT
is: Q06203
initial amount: NaN
is encoded by: hsa:5471

metaR OCCOAtx
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
name: fatty acid intracellular transport
product: MODEL1310110018#
type: Reaction

metaM eicostet e
constant: false
has only substance units: false
is: HMDB02177
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
boundary condition: false
is: SBO:0000247
name: eicosatetranoic acid

metaM cs e deg4 l
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4

metaM atp n
is: CHEBI:57299
is: HMDB00538
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: ATP(3-)
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002

metaR r2362
is: SBO:0000185
fast: false
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR FAOXC225C226m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM ksii core2 pre9 g
is: CHEBI:28067
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r1671
type: Reaction
modifier: MODEL1310110018#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110018#
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110018#
kinetic law: MODEL1310110018#

metaR NACHEX1ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
reversible: false
kinetic law: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
modifier: MODEL1310110018#

metaM dece3coa m
type: Species
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3-decenoylcoa
initial amount: NaN
initial concentration: 1.0
constant: false

metaR OIVD3m
is described by: ECO:0000269
product: MODEL1310110018#
is: SBO:0000176
kinetic law: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.2.4.4
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
fast: false
reactant: MODEL1310110018#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.168
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
modifier: MODEL1310110018#

metaR ALAR
is described by: ECO:0000212
reactant: MODEL1310110018#
is: SBO:0000176
fast: false
product: MODEL1310110018#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: alanine racemase
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
type: Reaction
reversible: true

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR TMNDNCt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110018#
type: Reaction
reversible: true

metaM hdd2coa m
initial amount: NaN
is: HMDB03945
constant: false
is: SBO:0000247
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
type: Species
has only substance units: false
is: C05272
initial concentration: 1.0

metaM Rtotalcoa c
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01448
initial concentration: 1.0
type: Species
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
boundary condition: false
initial amount: NaN

metaM adprib e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 INCHI: InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/p-2/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C00301
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01178
name: D-ribofuranos-5-yl-ADP(2-)
type: Species
is: CHEBI:57967

metaM acnam l
initial concentration: 1.0
is: HMDB00230
boundary condition: false
is: SBO:0000247
name: N-acetylneuraminate
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
has only substance units: false
constant: false
is: CHEBI:35418

http://identifiers.org/biomodels.db/MODEL1310110018#_f85af68c_904d_45e6_aa05_49dc77b26341
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:BC005314
name: _BC005314_1_x
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR FAOXC122m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM prostgf2 c
is: HMDB01139
is: CHEBI:57404
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin F2alpha(1-)

metaR r2361
fast: false
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110018#
reactant: MODEL1310110018#
kinetic law: MODEL1310110018#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR FAOXC183C163Gm
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM atp m
is: SBO:0000247
boundary condition: false
name: ATP(4-)
is: HMDB00538
type: Species
is: C00002
has only substance units: false
initial amount: NaN
is: CHEBI:57299
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_2e2ad285_edaa_4d55_8fe7_1c07d3b805ad
type: Species
is: Q7Z3X3
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2799
constant: false
name: GNS
boundary condition: true
initial concentration: NaN

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR CERT1rt
is: SBO:0000185
is described by: ECO:0000304
fast: false
product: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
reactant: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110018#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_021921e6_b960_42c0_8106_bb873c2e5d04
initial amount: NaN
is encoded by: hsa:AI620219
boundary condition: true
name: _AI620219_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR LPASE
is described by: ECO:0000000
reactant: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
fast: false
kinetic law: MODEL1310110018#
name: lysophospholipase
product: MODEL1310110018#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.5
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110018#_db0fcb32_983d_4d0e_ad3a_18c8680dfe22
constant: false
is: P55084
boundary condition: true
initial concentration: NaN
name: HADHB
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:3032

metaR ACNAMPH
reactant: MODEL1310110018#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_a7fd8eb7_6bca_4fef_920d_fcf6a78fdb16
constant: false
type: Species
is encoded by: hsa:8876
has part: O95497
is encoded by: hsa:8875
has part: A8K7W0
initial amount: NaN
boundary condition: true
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
initial concentration: NaN
is: SBO:0000297
has only substance units: false

metaR r2360
product: MODEL1310110018#
kinetic law: MODEL1310110018#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110018#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction

metaM ppcoa m
is: C00100
has only substance units: false
initial concentration: 1.0
constant: false
name: Propanoyl-CoA
is: CHEBI:57392
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR UDPGALtg
product: MODEL1310110018#
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
reversible: true
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110018#

metaR FAOXC102C81m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM nmn c
is: SBO:0000247
is: HMDB00229
is: CHEBI:14649
initial amount: NaN
has only substance units: false
name: NMN
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
initial concentration: 1.0
boundary condition: false
is: C00455

http://identifiers.org/biomodels.db/MODEL1310110018#_5327ef31_6e00_47f9_b6fc_22bd7272762b
type: Species
constant: false
is: O75251
boundary condition: true
name: NDUFS7
has only substance units: false
is encoded by: hsa:374291
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM ksi deg7 l
boundary condition: false
is: HMDB00812
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN
name: keratan sulfate I, degradation product 7
type: Species

metaR SERDGLYexR
modifier: MODEL1310110018#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110018#
is: SBO:0000185
reactant: MODEL1310110018#
reversible: true
type: Reaction
name: D-Serine/Glycine reversible exchange
product: MODEL1310110018#

metaM pa hs c
has only substance units: false
type: Species
is: CHEBI:57739
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110018#_a7a4ac3a_8baf_49c9_84c5_90e4538cabb6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9377
name: COX5A
has only substance units: false
type: Species
is: P20674
boundary condition: true
constant: false

metaM rib D c
is: SBO:0000247
is: CHEBI:16988
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00283
constant: false
initial amount: NaN
name: D-ribose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

http://identifiers.org/biomodels.db/MODEL1310110018#_31357fca_894e_455c_93ed_794d02a998af
name: GLRX2
constant: false
is encoded by: hsa:51022
is: SBO:0000252
is: Q9NS18
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM adprib c
type: Species
is: CHEBI:57967
is: HMDB01178
initial concentration: 1.0
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 EHMN_ABBREVIATION: C00301
is: SBO:0000247
name: ADPribose
is: C00301
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM HC02179 c
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:34306
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM Rtotal2 c
is: C00055
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: R total 2 position
is: HMDB00095
has only substance units: false
is: CHEBI:60377
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN

metaM Tn antigen l
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
name: Tn antigen
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaM dhcholestanate m
has only substance units: false
initial concentration: 1.0
is: HMDB00359
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577

metaR RE0688E
name: RE0688
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_057cce09_aad3_4a27_8ae2_09ccc5ed841f
is: SBO:0000252
initial amount: NaN
name: NT5C
is encoded by: hsa:30833
initial concentration: NaN
is: Q8TCD5
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_7f6bd84c_e452_466d_b21a_60451b6a97c0
is: B2RDU6
has only substance units: false
is: SBO:0000252
name: MVK
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4598
initial amount: NaN

metaM sucr e
is: SBO:0000247
is: C00089
initial concentration: 1.0
name: Sucrose
constant: false
initial amount: NaN
is: CHEBI:17992
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: HMDB00258

http://identifiers.org/biomodels.db/MODEL1310110018#_ba4837af_b2de_4fca_9fbd_5939a9722791
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: CPT1B
boundary condition: true
is: Q53FV7
is: SBO:0000252
is encoded by: hsa:1375
type: Species

metaM udpglcur r
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
has only substance units: false
is: HMDB00935
is: SBO:0000247
name: UDP-D-glucuronate
is: CHEBI:58052
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_849c414e_9a16_4c3f_ba47_f794ce639d44
constant: false
is encoded by: hsa:26289
has only substance units: false
is: Q9Y6K8
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: AK5
is: SBO:0000252

metaR RNDR2
kinetic law: MODEL1310110018#
is: SBO:0000176
modifier: MODEL1310110018#
product: MODEL1310110018#
name: ribonucleoside-diphosphate reductase (GDP)
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
reactant: MODEL1310110018#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110018#_920529a6_61af_4ab9_84a5_1bdbda3d71d1
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q969I6
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:55089
name: SLC38A4

http://identifiers.org/biomodels.db/MODEL1310110018#_fe6787e7_0ac1_4e37_a62a_6ed7aab9dd90
initial concentration: NaN
boundary condition: true
is: P31040
type: Species
constant: false
is: SBO:0000252
name: SDHA
initial amount: NaN
has only substance units: false
is encoded by: hsa:6389

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial amount: NaN
is: HMDB01487
constant: false
name: Nicotinamide adenine dinucleotide - reduced
type: Species
has only substance units: false
is: C00004
is: SBO:0000247
is: CHEBI:57945
initial concentration: 1.0

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR r2366
reactant: MODEL1310110018#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110018#
is: SBO:0000185
product: MODEL1310110018#

metaR PTRCOX1
reactant: MODEL1310110018#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000304
name: Putrescine:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110018#
product: MODEL1310110018#

metaR PROSTGI2tr
is described by: ECO:0000269
product: MODEL1310110018#
name: Prostaglandin I2 transport (ER)
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaM h e
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
name: proton
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080

metaR RNDR1
is: SBO:0000176
is described by: ECO:0000254
reversible: false
product: MODEL1310110018#
type: Reaction
reactant: MODEL1310110018#
fast: false
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110018#_c5171dee_2686_4339_8be6_d3104e87214c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:51727
is: B2R6S5
name: CMPK1
initial amount: NaN
boundary condition: true

metaM 3hexdtricoa m
is: HMDB02288
boundary condition: false
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_d1509a64_b7f0_4fc9_a71e_9ac974b8295b
boundary condition: true
name: ACLY
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:47
type: Species
has only substance units: false
is: SBO:0000252

metaR FAOXC164GC163m
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR XOL27OHtm
is: SBO:0000185
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110018#
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110018#
reversible: true
type: Reaction

metaM occoa c
is: HMDB01070
is: SBO:0000247
initial amount: NaN
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: CHEBI:57386
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110018#_38352258_b026_484d_9678_8afb349fd5f6
has only substance units: false
is: O15305
name: PMM2
boundary condition: true
is encoded by: hsa:5373
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110018#_67f7ed15_b930_4cc7_b739_5f62d116269c
is: B4E0V8
boundary condition: true
is encoded by: hsa:3034
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: HAL

metaR r2365
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction

metaM eicostet c
initial concentration: 1.0
is: SBO:0000247
name: eicosatetranoic acid
type: Species
is: CHEBI:36033
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
constant: false
is: HMDB02177
boundary condition: false

metaR r1918
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#

metaM met L e
name: L-methionine
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
initial concentration: 1.0
is: HMDB00696
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16643

metaR AACOAT
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
kinetic law: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110018#
reactant: MODEL1310110018#
name: Acetoacetyl-CoA:acetate CoA-transferase
type: Reaction
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_32f628e3_d4d6_4f6c_b84b_5e1cdd6a1655
is: SBO:0000252
initial amount: NaN
constant: false
is: Q11201
boundary condition: true
name: ST3GAL1
type: Species
is encoded by: hsa:6482
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110018#_31e30134_99ec_4096_b376_6ae2a5d489e2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: DUOX1
is encoded by: hsa:53905
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110018#_63c64002_4f0b_4869_ba0a_33990d9f2c48
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9Y2C3
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10317
name: B3GALT5
is: SBO:0000252

metaR S2L2FN2M2MASNt
fast: false
reversible: false
name: s2l2fn2m2masn transport, Golgi to extracellular
reactant: MODEL1310110018#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110018#
product: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR CORE2GTg
reactant: MODEL1310110018#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110018#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110018#
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110018#
is: SBO:0000176

metaM dolglcp U c
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15812
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
constant: false

metaR CYSTA
name: cysteine transaminase
reversible: true
is described by: ECO:0000304
modifier: MODEL1310110018#
fast: false
reactant: MODEL1310110018#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
product: MODEL1310110018#

metaR S6T1g
kinetic law: MODEL1310110018#
product: MODEL1310110018#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110018#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110018#_42ddb096_5f59_4ec0_bf97_af0d28db9e5c
is: F5H2Y9
is: SBO:0000252
type: Species
is encoded by: hsa:8854
initial concentration: NaN
name: ALDH1A2
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaR r2364
reversible: true
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110018#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
is: SBO:0000185

metaM dcsptn1crn c
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

http://identifiers.org/biomodels.db/MODEL1310110018#_990ef9c8_1b6c_4aa6_83f1_8a4317e1e3bb
initial concentration: NaN
is: Q9P0Z9
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PIPOX
has only substance units: false
is encoded by: hsa:51268

metaM l2n2m2mn l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00143
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)

http://identifiers.org/biomodels.db/MODEL1310110018#_7fa1cc1d_6721_4de9_867e_d21b9e2fbdc8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q5T4Y1
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
constant: false
type: Species
initial amount: NaN

metaM acnam n
type: Species
initial amount: NaN
name: N-acetylneuraminate
initial concentration: 1.0
is: HMDB00230
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418

metaR PRPPS
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
name: phosphoribosylpyrophosphate synthetase
modifier: MODEL1310110018#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110018#_3c0a9154_9027_4982_bc69_1f7d8de3ada5
constant: false
type: Species
name: CH25H
initial amount: NaN
is encoded by: hsa:9023
initial concentration: NaN
boundary condition: true
is: O95992
has only substance units: false
is: SBO:0000252

metaM h c
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
type: Species
is: C00080
is: SBO:0000247

metaR DRPA
reactant: MODEL1310110018#
is described by: ECO:0000000
kinetic law: MODEL1310110018#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
name: deoxyribose-phosphate aldolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_830e4ac1_5753_417a_bda7_b44fd4223b36
type: Species
has only substance units: false
constant: false
is: Q96L53
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
boundary condition: true

metaM succoa x
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Succinyl-CoA
is: HMDB01022

metaM T antigen g
is: CHEBI:22783
constant: false
name: T antigen (core 1)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110018#_90f8f749_6fe1_45c8_abfb_3ab72b6fc368
type: Species
has only substance units: false
is encoded by: hsa:6574
constant: false
is: Q8WUM9
name: SLC20A1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR AKR1D
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
product: MODEL1310110018#
modifier: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.3
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110018#

metaR r2363
is described by: ECO:0000000
type: Reaction
product: MODEL1310110018#
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_fe0b6467_c600_4fb5_bffa_231f66f586bc
is: Q8NFF5
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: FLAD1
is encoded by: hsa:80308
initial concentration: NaN
constant: false

metaM prostgf2 e
initial concentration: 1.0
is: CHEBI:57404
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01139
type: Species
boundary condition: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaR r2379
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110018#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110018#_34bb7cd4_fc89_4830_92b2_09f21436899e
initial amount: NaN
initial concentration: NaN
has part: Q14442
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277
has part: B3KUV7
has part: Q9BRB3
constant: false
is encoded by: hsa:5279
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5283
is encoded by: hsa:9091
has only substance units: false
has part: Q92535
has part: O94777
type: Species
is encoded by: hsa:8818

metaM cholcoaone x
is: HMDB06891
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: CHEBI:58507
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
has only substance units: false

metaR CSAPASEly
product: MODEL1310110018#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
reversible: false
is: SBO:0000176
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_35946e0e_9f24_4e04_9cec_cdee7934f378
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PIGP
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51227
is: P57054
type: Species

metaR FACOAL200
name: fatty-acid--CoA ligase
type: Reaction
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110018#
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110018#

http://identifiers.org/biomodels.db/MODEL1310110018#_f3d857fa_7e11_4083_b57f_8a41b2d9ea22
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NYR8
initial concentration: NaN
is encoded by: hsa:50700
name: RDH8

metaR LCYSTCBOXL
reactant: MODEL1310110018#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.29
modifier: MODEL1310110018#
kinetic law: MODEL1310110018#
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
product: MODEL1310110018#
is: SBO:0000176
name: 3-Sulfoalanine carboxy-lyase

metaR DHFR
is: SBO:0000176
reactant: MODEL1310110018#
name: dihydrofolate reductase
modifier: MODEL1310110018#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
type: Reaction
is described by: ECO:0000254
product: MODEL1310110018#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reversible: true
kinetic law: MODEL1310110018#

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110018#
product: MODEL1310110018#
reactant: MODEL1310110018#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110018#
reactant: MODEL1310110018#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM cs b deg1 l
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial concentration: 1.0
is: HMDB00812
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:16953