http://identifiers.org/biomodels.db/MODEL1310110017#_0710dd71_98bc_4a21_b051_411b2cbf40bc
boundary condition: true
name: GMPR
is: SBO:0000252
is: P36959
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2766
type: Species

metaR r1592
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR PCHOLHSTDe
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR AKR1C41
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c7b74a36_8baa_4bdb_9972_d860e1e393b5
is: O14561
initial amount: NaN
has only substance units: false
is encoded by: hsa:4706
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: NDUFAB1

metaR r0590
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
modifier: MODEL1310110017#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_b6017194_00a2_41cd_b56c_701009209e47
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P33897
is: SBO:0000252
name: ABCD1
constant: false
initial amount: NaN
is encoded by: hsa:215
type: Species

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r1640
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000

metaM CE2417 m
is: CHEBI:28387
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_eb84fa51_5500_4062_a446_8b45d12e2c6c
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:26289
name: AK5

metaM h n
name: proton
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
boundary condition: false
has only substance units: false
constant: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r2103
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ebf46f84_aeb7_4e76_910f_50605ba6c7c8
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9BZX2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7371
name: UCK2
has only substance units: false
constant: false

metaM but e
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17968
name: butyrate
boundary condition: false

metaR r1591
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1742
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport

metaM 2dr5p c
type: Species
constant: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57651
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: HMDB01031

metaM dpcoa e
constant: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Dephospho-CoA
initial concentration: 1.0
is: C00882
has only substance units: false

metaR GLCAASE9ly
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
is: SBO:0000176

metaR r1641
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110017#

metaR DURAD
is: SBO:0000176
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
fast: false
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.1.2

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_546cd372_f99b_4761_ac51_5e711973d7fa
initial amount: NaN
has only substance units: false
boundary condition: true
name: GCDH
type: Species
is: Q92947
is: SBO:0000252
constant: false
is encoded by: hsa:2639
initial concentration: NaN

metaR RE2658R
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
name: RE2658
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false

metaR ACCOAtn
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false
reversible: true
name: acetyl-CoA transport, nuclear
product: MODEL1310110017#
is described by: ECO:0000000

metaR TYRt
reversible: true
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000269
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false

metaM occoa m
has only substance units: false
is: CHEBI:57386
boundary condition: false
initial concentration: 1.0
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
initial amount: NaN
is: SBO:0000247
type: Species
is: C01944

metaR r2104
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185

metaM h m
type: Species
has only substance units: false
initial concentration: 1.0
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
boundary condition: false
initial amount: NaN
is: CHEBI:24636
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380

metaR ACONTm
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000134
reversible: true
type: Reaction
product: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
name: Aconitate hydratase
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical

metaR GLUt7l
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
name: Glutamate transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110017#_4e4c5182_ddb9_456e_9dc5_31ebf82aa8e3
has only substance units: false
is: B3KNC1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51733
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: UPB1

http://identifiers.org/biomodels.db/MODEL1310110017#_a59ae2d1_6b24_4a58_bacc_9467c9105786
initial amount: NaN
is: Q96P26
is encoded by: hsa:93034
constant: false
is: SBO:0000252
name: NT5C1B
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaR r1594
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#

metaR FPGS4m
reversible: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: folylpolyglutamate synthetase (DHF), mitochondrial
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110017#_4f9b8d04_607c_43a1_b706_a8f0cdb775d8
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5169
initial concentration: NaN
is: Q308M7
initial amount: NaN
constant: false
name: ENPP3
has only substance units: false

metaR r1642
reversible: true
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_5e7fec23_3c25_4ef2_ae99_417e3b1ac7ec
initial amount: NaN
name: NT5C3
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q9H0P0
is encoded by: hsa:51251
is: SBO:0000252

metaM dgtp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
is: C00286
is: HMDB01440
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:16497
is: SBO:0000247

metaR r2105
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
type: Reaction
reversible: true
fast: false

metaM h l
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: proton

metaR KCCt
name: K+-Cl- cotransport
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR RE0452M
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
name: RE0452
type: Reaction
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false

metaR r0817
kinetic law: MODEL1310110017#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
type: Reaction
modifier: MODEL1310110017#
reversible: true
product: MODEL1310110017#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2

metaR r1593
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00039
name: butyrate
is: SBO:0000247
is: CHEBI:17968
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_688d760a_b4a1_406d_91c8_919526ad43f9
type: Species
is encoded by: hsa:4952
name: OCRL
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q01968
is: SBO:0000252
initial concentration: NaN

metaM dpcoa c
is: CHEBI:57328
name: Dephospho-CoA
constant: false
is: HMDB01373
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaR r1643
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_4a1243df_6e32_4501_bc10_7295fb029687
constant: false
initial concentration: NaN
has part: P07195
has only substance units: false
type: Species
name: LDHA:LDHB
initial amount: NaN
has part: P00338
is encoded by: hsa:3945
boundary condition: true
is encoded by: hsa:3939
is: SBO:0000297

metaR r2106
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_6deeaf02_a5ba_4df5_8293_48fda2e0202a
initial amount: NaN
type: Species
is: Q9UBY0
boundary condition: true
is: SBO:0000252
name: SLC9A2
is encoded by: hsa:6549
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_da80aaff_a97a_47ba_aa64_c80e69a11292
type: Species
boundary condition: true
name: SLC29A2
has only substance units: false
is encoded by: hsa:3177
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q14542
initial amount: NaN

metaR r1644
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#

metaM uacgam c
is: CHEBI:57705
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: HMDB00290
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

metaM thym c
initial amount: NaN
is: CHEBI:17821
is: HMDB00262
is: C00178
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Thymine
constant: false

metaR r1963
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_6ff506b3_8077_4833_8145_96b1c2df27c7
constant: false
type: Species
name: _NM_013421_1_m
is encoded by: hsa:NM 013421
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM h r
name: proton
is: C00080
constant: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: SBO:0000247
type: Species

metaM pd3 c
is: HMDB06500
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: Previtamin D3
type: Species
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1

metaM HC02202 c
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin A1(1-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
has only substance units: false
is: CHEBI:57398
type: Species

metaR RE1233C
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
name: RE1233
reactant: MODEL1310110017#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is version of: http://identifiers.org/ec-code/2.6.1.64

metaR r2107
product: MODEL1310110017#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM hom L c
is: HMDB00719
has only substance units: false
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: L-homoserine

metaR r1645
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110017#

metaM pro D c
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16313
constant: false
is: HMDB03411
boundary condition: false
name: D-proline
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_198e58bc_1f8a_4d59_950d_ff91b824b3a6
type: Species
initial concentration: NaN
name: CDO1
is encoded by: hsa:1036
has only substance units: false
constant: false
is: Q16878
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM leuktrD4 e
name: Leukotriene D4
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28666
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
is: HMDB03080
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a7857d3f_357c_4e02_ac95_fb267db98ee5
boundary condition: true
initial concentration: NaN
name: SLC5A2
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: P31639
is encoded by: hsa:6524
type: Species

metaM retinal cis 9 r
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17898
has only substance units: false
is: HMDB01358
is: SBO:0000247
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false

metaM sphmyln hs c
notes: FORMULA: CHARGE: 0
name: sphmyln_hs[c]
is: CHEBI:15589
has only substance units: false
is: HMDB00156
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR r2108
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR FATP2t
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
is described by: ECO:0000269
name: fatty acid electroneutral transport
product: MODEL1310110017#
fast: false
reversible: true
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_a8b93c32_2008_4944_a2f8_3bf4cad447db
type: Species
is encoded by: hsa:92579
name: G6PC3
is: Q9BUM1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR GLCter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
name: glucose transport, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_83b3167c_47c9_427f_bbdb_44b63dfbe6a0
constant: false
initial amount: NaN
name: ACADM
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P11310
is: SBO:0000252
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110017#_94583e01_03a7_4321_b56f_a1b17687e650
boundary condition: true
is encoded by: hsa:6391
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: SDHC
is: SBO:0000252
is: Q99643
initial amount: NaN

metaR r1646
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR AMETtd
fast: false
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110017#

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110017#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 3odcoa m
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
boundary condition: false
is: CHEBI:28528
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-Oxodecanoyl-CoA
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_43103ffe_8512_42e5_af01_d50ae5841dfd
boundary condition: true
is: Q8N1Q1
has only substance units: false
initial amount: NaN
is encoded by: hsa:377677
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: CA13

http://identifiers.org/biomodels.db/MODEL1310110017#_ecab6a32_18f0_4f6d_82a8_537a7370f218
initial amount: NaN
boundary condition: true
name: ACP2
has only substance units: false
initial concentration: NaN
constant: false
is: E9PCI1
is encoded by: hsa:53
is: SBO:0000252
type: Species

metaM hom L e
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:15699
boundary condition: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
has only substance units: false
initial concentration: 1.0

metaR LEUPHELAT2tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM HC02202 e
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
is: CHEBI:57398

metaM 4hpro LT e
is: SBO:0000247
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
has only substance units: false
name: trans-4-hydroxy-L-proline
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM for m
constant: false
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
type: Species
initial amount: NaN
name: formate
is: CHEBI:15740
has only substance units: false
is: SBO:0000247
is: HMDB00142

metaR MTHFD2m
kinetic law: MODEL1310110017#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is described by: ECO:0000254
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true

metaR TRDR
is described by: ECO:0000269
fast: false
reactant: MODEL1310110017#
reversible: false
name: thioredoxin reductase (NADPH)
product: MODEL1310110017#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110017#

metaR r2109
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#

metaM xtsn c
name: xanthosine
is: SBO:0000247
is: HMDB00299
is: CHEBI:18107
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f1984c40_0c45_4a20_b0ba_e467cb6fe4f7
is encoded by: hsa:286016
boundary condition: true
name: TPI1P2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_81fce329_1ea5_47f0_8973_2374e2e1f400
is: SBO:0000252
name: RDH13
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: B3KVA3
is encoded by: hsa:112724
constant: false

metaR r1647
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_297b8ffc_f01e_4147_876c_b1785ddc7ff9
is: Q9NY65
has only substance units: false
name: EHHADH
is: SBO:0000252
is encoded by: hsa:1962
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM pro D e
name: D-proline
boundary condition: false
is: CHEBI:16313
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
is: HMDB03411
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_0abe40e1_fe2b_456c_ac8f_61534be4a93a
name: SLC15A2
initial amount: NaN
type: Species
boundary condition: true
is: Q16348
is encoded by: hsa:6565
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR r0812
type: Reaction
product: MODEL1310110017#
modifier: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110017#_270c68ce_98fb_4a0e_a96b_f80aadfd63bd
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4833
initial concentration: NaN
name: NME4
boundary condition: true
initial amount: NaN
type: Species
is: O00746
constant: false

metaM 3mop e
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: HMDB00491
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

metaR 3SPYRSP
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is: SBO:0000176

metaR NDP7g
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110017#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#
fast: false
is described by: ECO:0000269
reversible: false

metaR r2333
kinetic law: MODEL1310110017#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_d2f54b59_36cb_4a56_ba46_c5502a5fee99
has only substance units: false
name: _BE966236_1_c
is encoded by: hsa:BE966236
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_98cef3d2_1f47_419c_950b_19867fdf291e
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:728226
name: _728226_1_e

metaM acmana r
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
type: Species
initial amount: NaN
is: HMDB01129
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: N-acetyl-D-mannosamine

metaR SPHS1Pte
type: Reaction
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

http://identifiers.org/biomodels.db/MODEL1310110017#_16bb5907_9625_4055_b6ce_dc8a81da1793
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: P16278
name: GLB1
boundary condition: true
has only substance units: false
is encoded by: hsa:2720
constant: false

metaR r1257
name: EC:6.2.1.3
reversible: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000

metaM h e
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: CHEBI:24636
boundary condition: false
initial amount: NaN
is: C00080
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247

metaR NS26Tg
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
fast: false
reversible: false
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.99.3

http://identifiers.org/biomodels.db/MODEL1310110017#_3c0218e1_7e7d_4b39_bc64_24baf4c58a11
is: SBO:0000252
is encoded by: hsa:H53099
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: _H53099_1_m
initial concentration: NaN

metaM dttp n
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
is: C00459
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:37568
is: HMDB01342
initial concentration: 1.0
has only substance units: false
type: Species
name: dTTP

metaR CYSPHELAT2tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_2acd1895_db88_4101_b1bf_33a1eda3231f
boundary condition: true
type: Species
is encoded by: hsa:1717
name: DHCR7
initial concentration: NaN
is: Q9UBM7
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_a67e0767_5278_4a98_8beb_ff1399ba31ff
is encoded by: hsa:2589
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: GALNT1
is: Q10472
initial amount: NaN

metaR MTHFDm
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
product: MODEL1310110017#
modifier: MODEL1310110017#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false

metaR GLYOp
fast: false
product: MODEL1310110017#
name: glycine oxidase, perixosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaR r2334
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_15874ebf_de70_4b4c_adca_eb4a14d01634
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM 4nph e
initial amount: NaN
name: 4-nitrophenolate
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57917
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
constant: false
is: HMDB01232

http://identifiers.org/biomodels.db/MODEL1310110017#_a708859f_8351_42a9_98e3_12836279243d
constant: false
is encoded by: hsa:55753
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9ULD0
initial amount: NaN
name: OGDHL
has only substance units: false

metaM bilirub r
initial concentration: 1.0
initial amount: NaN
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: bilirubin(2-)
boundary condition: false

metaR r0472
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110017#

metaM for c
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
constant: false
is: C00058
type: Species
has only substance units: false
is: HMDB00142
name: Formate
initial concentration: 1.0
is: CHEBI:15740
initial amount: NaN
boundary condition: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM dpcoa m
is: SBO:0000247
constant: false
initial amount: NaN
name: 3'-dephospho-CoA(2-)
is: HMDB01373
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_5afe9806_b9ee_46af_8644_9b96749354d4
name: ALDH1B1
is: P30837
has only substance units: false
is encoded by: hsa:219
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_27e5ceb2_c3f6_4e3e_ad47_7714a5358751
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GPD1
type: Species
is: F8W1L5
initial concentration: NaN
constant: false
is encoded by: hsa:2819
initial amount: NaN

metaR FUMTSULtm
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
fast: false
reversible: true
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
reactant: MODEL1310110017#
modifier: MODEL1310110017#

metaM pe hs r
is: CHEBI:16038
is: SBO:0000247
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_302a86c8_cbfe_4d43_a81c_5108a2631b3c
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI222095_1_e
initial amount: NaN
is encoded by: hsa:AI222095

metaR PE HSter
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110017#

metaR RNDR2
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
is described by: ECO:0000254
kinetic law: MODEL1310110017#
type: Reaction
name: ribonucleoside-diphosphate reductase (GDP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110017#_8bbdc27b_7ace_429b_aaf8_30d0a15152c3
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: GOT1
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2805
is: P17174

metaM h c
is: SBO:0000247
is: CHEBI:24636
constant: false
boundary condition: false
is: C00080
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "

metaR HIStN1
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110017#
reversible: true

metaR PMTCOAFABP1tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of palmitoyl coA into the enterocytes
type: Reaction

metaR r1538
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110017#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_aff5ce44_dac2_4170_8725_3b05d852e240
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC6A9
constant: false
is encoded by: hsa:6536
is: B7Z3W8

metaM dpcoa l
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01373
type: Species
initial concentration: 1.0
has only substance units: false
name: 3'-dephospho-CoA(2-)

http://identifiers.org/biomodels.db/MODEL1310110017#_30fd3642_04d3_4ed8_b0ae_4a18544b7f24
is encoded by: hsa:57835
name: SLC4A5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9BY07
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_31c9b0cb_bf16_498f_9767_b9c92df550e7
has only substance units: false
constant: false
initial amount: NaN
name: SDHD
is encoded by: hsa:6392
is: O14521
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR D LACt2
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
is described by: ECO:0000269
reversible: true
name: D-lactate transport via proton symport
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_aa6c9f2e_da48_40a5_99e2_52eb24369ea2
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:7001
initial concentration: NaN
name: PRDX2
constant: false
boundary condition: true
is: SBO:0000252

metaR RE1573M
type: Reaction
reactant: MODEL1310110017#
name: RE1573
kinetic law: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
is described by: ECO:0000000

metaM pail5p hs n
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
initial amount: NaN
type: Species

metaR CO2t
fast: false
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion

metaR RNDR1
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (ADP)
reversible: false
is described by: ECO:0000254
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#

metaR LPS
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
is version of: http://identifiers.org/ec-code/3.1.1.34
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reversible: false
name: lipase

metaR AKR1D
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
is described by: ECO:0000269

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110017#
name: Choline kinase
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: false
fast: false

metaM so3 c
is: HMDB00240
is: CHEBI:17137
is: SBO:0000247
boundary condition: false
name: Sulfite
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
is: C00094

http://identifiers.org/biomodels.db/MODEL1310110017#_01c14d9f_e42d_4eda_b24e_e7f98f47e207
constant: false
initial concentration: NaN
name: HADHB
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3032
has only substance units: false
is: P55084

metaR ORNt4m
reversible: true
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
modifier: MODEL1310110017#
name: ornithine mitochondrial transport exchange with citruline
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110017#

metaM accoa c
constant: false
has only substance units: false
is: C00024
is: HMDB01206
is: CHEBI:57288
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: Acetyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species

metaM btn e
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:3420
is: SBO:0000247
has only substance units: false
is: C00120
type: Species
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
is: HMDB00030

metaR RE3520E
modifier: MODEL1310110017#
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reversible: true
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.11.1.9

http://identifiers.org/biomodels.db/MODEL1310110017#_24f871ae_299e_42fb_a383_e9eb0f1f2b14
constant: false
is: O95992
name: CH25H
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9023
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM xol7ah c
name: 7alpha-hydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB06892
is: CHEBI:2290
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR LEUKTRD4t
fast: false
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
name: leukotriene D4 transport
is: SBO:0000185
type: Reaction
product: MODEL1310110017#

metaR r2338
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction

metaR O2St
reactant: MODEL1310110017#
name: superoxide anion transport via diffusion (extracellular)
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110017#

metaR LAPCOAl
reactant: MODEL1310110017#
is: SBO:0000176
name: lysosomal acid phosphorylase (CoA)
fast: false
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110017#
reversible: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_08f77800_608c_4158_b20d_3aa8a49478b9
type: Species
initial amount: NaN
has only substance units: false
is: Q9BY49
name: PECR
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:55825
is: SBO:0000252

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
initial amount: NaN
is: HMDB00014
is: CHEBI:15698
is: SBO:0000247
name: 2'-deoxycytidine
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR ABUTD
product: MODEL1310110017#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110017#
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_743aac8a_1a98_4985_9cd7_85c5c7fb10cf
initial concentration: NaN
type: Species
is: SBO:0000252
is: E9KL44
constant: false
initial amount: NaN
name: HADHA
boundary condition: true
has only substance units: false
is encoded by: hsa:3030

http://identifiers.org/biomodels.db/MODEL1310110017#_bfd27efe_0a3d_41bc_9f64_2772d0c55e77
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:26290
name: GALNT8
is: Q9NY28
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_cfa7a095_64db_4e06_a54c_735e097fadb7
is encoded by: hsa:NOS2A
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_ab5a10b0_7ab4_4fc4_8145_4c9f61d4f52e
initial concentration: NaN
is encoded by: hsa:8875
name: VNN2
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: O95498

metaR GLCURtly
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: glucuronate transport into lysososme
reactant: MODEL1310110017#
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaM 3mop c
type: Species
is: CHEBI:28654
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: HMDB00491
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_6eec0b83_1e2a_4a76_bc04_6ca684ad99b7
is: Q9Y217
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: MTMR6
is encoded by: hsa:9107
constant: false
type: Species

metaM 4hpro LT m
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: trans-4-hydroxy-L-proline
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
constant: false
is: CHEBI:18095
is: HMDB00725

http://identifiers.org/biomodels.db/MODEL1310110017#_64605e0a_ebcf_42de_9479_42272c9431e5
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: P05091
is encoded by: hsa:217
name: ALDH2
type: Species
is: SBO:0000252

metaM bilglcur r
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
initial concentration: 1.0

metaR r0475
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110017#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_13a7bc5d_2b54_41b2_ba50_3782796848fe
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AI620219
initial concentration: NaN
name: _AI620219_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_6e546a3b_c809_4d6c_9f56_55f0384d99cc
name: NDUFA7
initial amount: NaN
is: Q6FG42
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4701

http://identifiers.org/biomodels.db/MODEL1310110017#_9d378b65_7134_447a_a139_d7a242cf6e18
boundary condition: true
constant: false
has only substance units: false
name: _AA081045_1_m
is encoded by: hsa:AA081045
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
initial amount: NaN
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
boundary condition: false
is: C01936

metaR UPPN
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000176
name: b-ureidopropionase
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
product: MODEL1310110017#
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6

http://identifiers.org/biomodels.db/MODEL1310110017#_96674a13_fd31_445d_8ce9_fd72692c6ac4
initial concentration: NaN
is: P54687
boundary condition: true
is: SBO:0000252
has only substance units: false
name: BCAT1
initial amount: NaN
type: Species
is encoded by: hsa:586
constant: false

metaM h g
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
name: proton
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c3ce92ee_eb7a_4263_9630_b3f1648bafb3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: CPT1B
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1375
is: B7Z5T8

metaM for e
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00142
is: CHEBI:15740
name: formate
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
initial concentration: 1.0
constant: false

metaR DM T antigen g
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r0129
reactant: MODEL1310110017#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaR r0474
fast: false
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110017#
is: SBO:0000176

metaM kynate c
is: SBO:0000247
is: HMDB00715
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58454
name: kynurenate
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_add214c0_5729_4840_bb0b_7b0693f9892c
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:642502
has only substance units: false
type: Species
initial amount: NaN
name: _642502_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_e10907c6_851b_4465_b779_96c9bb79727e
is encoded by: hsa:440
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: B4DXZ1
initial amount: NaN
has only substance units: false
name: ASNS

metaR r1318
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
name: Transport reaction
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110017#

metaM f6p c
name: D-Fructose 6-phosphate
boundary condition: false
type: Species
constant: false
is: HMDB00124
is: C00085
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3385
is: CHEBI:57579
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_81fabb3b_7457_4b91_a36b_de1d314d7cd8
initial amount: NaN
constant: false
is: O00154
is encoded by: hsa:11332
initial concentration: NaN
name: ACOT7
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM HC01610 e
name: CoproporphyrinogenI
is: CHEBI:28607
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.41
is: SBO:0000176
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaR GCC2am
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: glycine-cleavage complex (lipoamide), mitochondrial
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true

metaM mercppyr c
is: HMDB01368
type: Species
constant: false
is: CHEBI:57678
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: SBO:0000247
name: 3-mercaptopyruvate
initial amount: NaN
has only substance units: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM 3mop m
initial amount: NaN
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: HMDB00491
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:28654
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaM ptth c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
type: Species
is: HMDB03426
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_7292bc8f_54d8_4ff2_8e04_896184d95a7b
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC9A3
is encoded by: hsa:6550
is: P48764

metaR GLUDym
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110017#
is: SBO:0000176
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_6457df57_8924_4d44_8ed0_26dcce5896f3
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3420
name: IDH3A:IDH3B:IDH3G
constant: false
is: SBO:0000297
has only substance units: false
boundary condition: true

metaR r0968
is: SBO:0000185
reversible: false
type: Reaction
name: Postulated transport reaction
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM ksii core2 deg1 l
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 1
is: HMDB00868
type: Species
constant: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: SBO:0000247
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110017#_9694e365_1791_4615_955a_2d88ca448aaa
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:5230
is: P00558
is: SBO:0000252
constant: false
initial concentration: NaN
name: PGK1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_35153944_25e0_4364_9aed_2ccc0cee7c85
initial amount: NaN
constant: false
is: Q5DSZ6
type: Species
is: SBO:0000252
name: UGT1A8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54576
boundary condition: true

metaR IDPtn
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110017#
name: IDP nuclear transport
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_418a8859_2c64_4752_9ade_264f3641ca33
name: OGDH
is: SBO:0000252
boundary condition: true
is: Q02218
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4967
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_cd5738af_719d_4cc7_a9cc_618922463ac9
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6520
is: P08195
name: SLC3A2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_aa8716a6_3774_46b4_8f7e_241ca1c83776
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AW277253
name: _AW277253_1_c
boundary condition: true
constant: false

metaM 5HPET c
is: HMDB01193
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57450
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: 5(S)-HPETE(1-)
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110017#_dab67e37_7611_4027_94a0_b1c82b9f9a1f
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
name: Gamma-glutamyltransferase
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176
fast: false
type: Reaction

metaR TYRTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110017#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110017#
name: tyrosine transaminase
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#

metaR DASCBR
name: dehydroascorbate reductase
reversible: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_6404f9ce_8fc5_4b95_b12a_c22caec8792f
type: Species
initial amount: NaN
initial concentration: NaN
name: ACHE
boundary condition: true
is encoded by: hsa:43
is: SBO:0000252
is: P22303
constant: false
has only substance units: false

metaM ivcoa m
has only substance units: false
is: CHEBI:57345
type: Species
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial amount: NaN
is: HMDB01113
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaM btn c
has only substance units: false
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
name: Biotin
type: Species
is: C00120
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3420
is: HMDB00030
constant: false
is: SBO:0000247

metaR ILETA
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269
name: isoleucine transaminase
kinetic law: MODEL1310110017#
fast: false

metaM lnlccrn m
is: HMDB06469
initial amount: NaN
boundary condition: false
name: Linoleyl carnitine
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_f153b838_36e5_44e6_a999_f45376294ab9
is: SBO:0000252
constant: false
is encoded by: hsa:11254
type: Species
initial amount: NaN
is: Q9UN76
name: SLC6A14
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR RE1516M
name: RE1516
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR GALtly
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110017#
name: galactose efflux from lysosome
is described by: ECO:0000000

metaM dag hs c
name: diglyceride
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:18035
initial concentration: 1.0

metaM cdpchol c
is: HMDB01413
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16436
name: CDPcholine
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_300158f2_9be1_400c_9a80_0e0f3d07a278
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P23921
constant: false
name: RRM1
type: Species
is encoded by: hsa:6240
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_47ff8dd3_0a2a_46d2_a509_0f19a6e18ab5
type: Species
boundary condition: true
initial concentration: NaN
is: Q16831
is: SBO:0000252
is encoded by: hsa:7378
name: UPP1
initial amount: NaN
has only substance units: false
constant: false

metaR RE3346C
type: Reaction
modifier: MODEL1310110017#
name: RE3346
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: true
fast: false
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM 2maacoa m
constant: false
is: HMDB01157
is: CHEBI:57335
boundary condition: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0

metaR r0480
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
type: Reaction
product: MODEL1310110017#
reversible: true
is: SBO:0000176
reactant: MODEL1310110017#

metaR BTNt2
kinetic law: MODEL1310110017#
fast: false
type: Reaction
modifier: MODEL1310110017#
name: Biotin reversible transport via proton symport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_3ce34144_ef1b_4ed3_a996_a0694b4a9528
is: Q6UWQ5
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: LYZL1
initial concentration: NaN
is encoded by: hsa:84569
constant: false
type: Species

metaR CERK
notes: GENE_ASSOCIATION: (64781.1) or (64781.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.7.1.138 Confidence Level: 4 AUTHORS: PMID:11956206 NOTES:NJ
fast: false
is: SBO:0000176
product: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
name: Ceramide kinase
is version of: http://identifiers.org/ec-code/2.7.1.138
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110017#_de1fc38c_45c8_4708_b92e_fd3182191d3d
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:11136
is: SBO:0000252
name: SLC7A9
initial amount: NaN
has only substance units: false
is: P82251
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_44fe00e8_ec2e_4312_92e3_e90c4a3df70d
boundary condition: true
is: P56181
is encoded by: hsa:4731
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NDUFV3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9f0dbf60_14a4_4359_a7be_43b9089ec9bd
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: TSTA3
is: Q13630
is encoded by: hsa:7264

metaM pmtcrn c
has only substance units: false
is: HMDB00222
initial amount: NaN
is: CHEBI:17490
name: L-palmitoylcarnitine
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247

metaR RIBt
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: ribose transport via diffusion
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_834e2675_44ed_4b43_8f21_3670b94f9252
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10400
name: PEMT
has only substance units: false

metaM Rtotalcoa c
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN
type: Species
is: HMDB01448
boundary condition: false
name: R total Coenzyme A
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110017#_085638bf_fea7_45bc_be6f_decb218ff8d4
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6566
is: B4DKS0
type: Species
constant: false
name: SLC16A1
boundary condition: true

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
is: CHEBI:17898
type: Species
initial amount: NaN
constant: false
name: all-trans-retinal
is: HMDB01358
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM atp e
is: C00002
is: SBO:0000247
constant: false
type: Species
name: ATP(4-)
initial amount: NaN
has only substance units: false
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
is: HMDB00538

metaR RE1523M
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: RE1523
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_96a400d6_00a2_471d_a65b_9e2bbd8f484b
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: DGKI
is encoded by: hsa:9162
is: O75912
is: SBO:0000252
initial amount: NaN
constant: false

metaM nad c
is: C00003
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57540
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
name: Nicotinamide adenine dinucleotide
is: HMDB00902

http://identifiers.org/biomodels.db/MODEL1310110017#_a0458c16_e13d_4cab_a7fc_ff38b10c6c12
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6888
is: P37837
is: SBO:0000252
constant: false
name: TALDO1
has only substance units: false
initial amount: NaN

metaM dtmp c
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01227
constant: false
initial amount: NaN
name: dTMP
is: CHEBI:26999
type: Species
is: C00364

metaR HSD17B42x
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaR r2341
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM glc D e
constant: false
initial amount: NaN
has only substance units: false
name: D-glucose
is: SBO:0000247
type: Species
is: CHEBI:4167
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_90b83012_a0da_409e_862a_01670519d7aa
name: SLC22A2
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:6582
is: O15244
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_bcfbef6f_3bcb_4e32_a7e4_9759db246eea
name: _BE042354_1_m
type: Species
has only substance units: false
constant: false
is encoded by: hsa:BE042354
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_db8fee7d_0ba9_44c9_863e_174338cd0da6
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:64078
initial amount: NaN
constant: false
name: SLC28A3
boundary condition: true
is: Q9HAS3

metaM maltttr e
type: Species
constant: false
is: HMDB01296
is: C02052
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
name: Maltotetraose
initial amount: NaN

metaM succ c
has only substance units: false
is: CHEBI:30031
constant: false
is: HMDB00254
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00042
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN

metaR r0587
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_76bf9f8f_8f85_4285_87b5_a6ef1dda694c
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: AFMID
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:125061
is: Q63HM1

http://identifiers.org/biomodels.db/MODEL1310110017#_d7ca3213_8b4b_4981_a204_baedd8910b6b
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:51022
type: Species
initial amount: NaN
is: SBO:0000252
name: GLRX2
initial concentration: NaN

metaR r2344
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110017#_79cd0fea_f738_4bee_88a4_c7e89c8e4e05
has only substance units: false
boundary condition: true
is encoded by: hsa:10449
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: P42765
name: ACAA2
initial amount: NaN

metaM so3 m
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
is: CHEBI:17137
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00240
type: Species
boundary condition: false
name: hydrogensulfite

metaR ASNtN1
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#

metaM orn m
boundary condition: false
is: CHEBI:46912
is: HMDB00214
name: Ornithine
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C01602
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110017#_fcd7727c_0fda_4481_9ed9_cfe0b0adeb1d
initial concentration: NaN
has only substance units: false
constant: false
name: CERK
type: Species
boundary condition: true
is: Q8TCT0
initial amount: NaN
is encoded by: hsa:64781
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_0bba99f5_d728_455a_a321_7b93b8860b58
type: Species
boundary condition: true
is encoded by: hsa:H77542
constant: false
name: _H77542_1_r
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0021
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
product: MODEL1310110017#
reversible: true

metaM sucsal m
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
type: Species
is: HMDB01259
name: Succinic semialdehyde
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57706
initial concentration: 1.0

metaR RE3628M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
fast: false
is: SBO:0000176
product: MODEL1310110017#
name: RE3628

http://identifiers.org/biomodels.db/MODEL1310110017#_fd93ef14_e988_45d2_ac2a_2ced3accbceb
is: SBO:0000252
name: RPIA
boundary condition: true
initial concentration: NaN
is: P49247
is encoded by: hsa:22934
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM vitd3 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
is: SBO:0000247
initial amount: NaN
name: calciol
constant: false
has only substance units: false
is: CHEBI:28940
is: HMDB00876

metaM atp c
is: HMDB00538
is: C00002
name: ATP(4-)
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:30616
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_36c30779_cf8f_42da_8d29_2dc80adb7f20
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7378
name: UPP1

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_25a9210d_be72_4697_819a_49387c6336a2
boundary condition: true
constant: false
name: ACAD8
type: Species
has only substance units: false
is: Q6ZWP6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27034
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_16f442a1_d4ad_4a02_819e_cc6b6b5efe18
name: DTYMK
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1841
is: P23919
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r0509
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
kinetic law: MODEL1310110017#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110017#

metaR PROt2r
is described by: ECO:0000304
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
is: SBO:0000185
name: L-proline reversible transport via proton symport
modifier: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_10d1e842_829d_43fa_9065_967907bb3640
is: P48735
is encoded by: hsa:3418
is: SBO:0000252
type: Species
initial concentration: NaN
name: IDH2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM dtmp e
initial concentration: 1.0
boundary condition: false
name: dTMP(2-)
is: SBO:0000247
is: HMDB01227
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f97ee896_509a_406a_9997_3d1ad23eaeb3
is: SBO:0000252
constant: false
is: Q6LEN5
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: CHAT
has only substance units: false
is encoded by: hsa:1103

metaR r1649
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
modifier: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_9987281d_6c69_49ef_a709_341b0a6292a5
has only substance units: false
initial amount: NaN
is encoded by: hsa:200010
boundary condition: true
is: E9PAK4
initial concentration: NaN
type: Species
name: SLC5A9
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_819fb27c_8b49_4111_8d11_2ef926d72863
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10599
boundary condition: true
constant: false
has only substance units: false
name: SLCO1B1
type: Species
is: Q9Y6L6

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_5bf3ddc9_f425_427c_a910_845dbcaf7821
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8525
is: SBO:0000252
type: Species
name: DGKZ
boundary condition: true
constant: false
is: B7Z6M3
initial amount: NaN

metaR r0504
modifier: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110017#
is: SBO:0000176
type: Reaction
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:

metaM glc D c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:4167
constant: false
name: D-glucose
is: HMDB00122
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
initial amount: NaN

metaR r0698
kinetic law: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
product: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
type: Reaction
reactant: MODEL1310110017#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110017#_7bca97ee_364c_4ccc_9cb9_63e67fdbcb18
has only substance units: false
is: SBO:0000252
name: RPIA
boundary condition: true
is: P49247
constant: false
initial amount: NaN
is encoded by: hsa:22934
type: Species
initial concentration: NaN

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
reversible: true
fast: false

metaM HC01409 m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: Hexanoyl-CoA
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
boundary condition: false

metaM oxa m
initial amount: NaN
type: Species
is: HMDB02329
name: oxalate(2-)
boundary condition: false
constant: false
is: CHEBI:30623
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR r1423
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110017#
name: Facilitated diffusion
reversible: false

metaM atp r
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57299
initial concentration: 1.0
type: Species
has only substance units: false
is: C00002
is: SBO:0000247
is: HMDB00538
name: ATP(4-)

metaM bilirub c
name: bilirubin(2-)
type: Species
has only substance units: false
is: HMDB00054
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
is: CHEBI:57977
boundary condition: false

metaR r1648
reversible: true
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR IMPD
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.205
is described by: ECO:0000134
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: IMP dehydrogenase
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_e8dea838_634d_449e_b6b9_c4dac92a4570
is encoded by: hsa:4758
has only substance units: false
name: GALNS:GLB1:NEU1:CTSA
has part: P10619
is encoded by: hsa:2588
type: Species
initial concentration: NaN
is: SBO:0000297
has part: P34059
constant: false
initial amount: NaN
has part: P16278
has part: Q99519
is encoded by: hsa:2720
is encoded by: hsa:5476
boundary condition: true

metaR 3MOBte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_404e1494_e7d1_4753_b17c_622284e6b0d6
is encoded by: hsa:8876
initial amount: NaN
constant: false
has part: A8K7W0
has part: O95497
has only substance units: false
is: SBO:0000297
is encoded by: hsa:8875
type: Species
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_68975afe_71bb_4302_bac8_548e276e42af
is encoded by: hsa:51809
name: GALNT7
type: Species
is: Q86SF2
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR ALAt2r
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304
fast: false
modifier: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
product: MODEL1310110017#
is: SBO:0000185

metaR r0616
reversible: true
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaM sTn antigen g
is: C00459
is: CHEBI:37568
boundary condition: false
name: sialyl-Tn antigen
type: Species
constant: false
is: HMDB01342
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H30N2O13X CHARGE: -1
is: SBO:0000247
has only substance units: false

metaM 2hb e
name: 2-Hydroxybutyrate
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00008
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
initial amount: NaN
constant: false

metaR r0960
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_389ea7fa_cf25_4bb1_b089_6acd95723daf
type: Species
is: SBO:0000252
name: SDHD
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: O14521
is encoded by: hsa:6392

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR CYANt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
name: Cyanide transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000

metaR GLNt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: L-glutamine reversible transport via sodium symport
type: Reaction
product: MODEL1310110017#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ac954db9_c95d_48e7_9a2c_51207d7aaae6
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PNP
constant: false
has only substance units: false
type: Species
is: P00491
initial concentration: NaN
is encoded by: hsa:4860

metaR r1588
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#

metaM aacoa m
type: Species
is: HMDB01484
constant: false
has only substance units: false
initial amount: NaN
name: acetoacetyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c656fcb5_f38a_407a_98f4_625bb4de8077
name: VNN3:VNN2:VNN1
boundary condition: true
has part: O95498
constant: false
has only substance units: false
type: Species
is encoded by: hsa:55350
is encoded by: hsa:8875
is: SBO:0000297
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_91fc8784_5e87_4eb4_ad4b_23dbad1b2c5c
boundary condition: true
name: ALPL
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:249
is: B7Z4Y6
initial amount: NaN
constant: false

metaM leuktrD4 c
is: CHEBI:28666
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03080
has only substance units: false
name: Leukotriene D4

metaR GLYt7 311 r
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110017#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true

metaR r2110
type: Reaction
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR NAGA2ly
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is: SBO:0000176
kinetic law: MODEL1310110017#
name: N-acetylgalactosaminidase, alpha-
is version of: http://identifiers.org/ec-code/3.2.1.49
modifier: MODEL1310110017#
product: MODEL1310110017#

metaM chlstol r
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
is: SBO:0000247
is: HMDB06842
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
initial concentration: 1.0
is: CHEBI:16290

http://identifiers.org/biomodels.db/MODEL1310110017#_e8800dc8_f9d0_45b5_a7d1_224b3fe73322
is: Q8WZ48
initial amount: NaN
boundary condition: true
is encoded by: hsa:1374
constant: false
name: CPT1A
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM 3aib D m
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: C03265
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0
type: Species
is: HMDB02299
initial amount: NaN

metaM C04849 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
type: Species
is: CHEBI:57449
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false

metaM 2hb c
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: CHEBI:1148
is: HMDB00008
boundary condition: false
name: 2-Hydroxybutyrate
has only substance units: false

metaR BILIRUBtr
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true
name: lipid, flip-flop intracellular transport

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r0618
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
type: Reaction

metaR r0584
modifier: MODEL1310110017#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
product: MODEL1310110017#

metaR r0130
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_665e09a5_5c3e_4cca_b414_0adb1983b236
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:F23536
boundary condition: true
initial concentration: NaN
type: Species
name: _F23536_1_m
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4e970328_245d_4aa7_b766_9adccb34bec0
is: SBO:0000252
has only substance units: false
name: GLRX
initial amount: NaN
is: P35754
boundary condition: true
type: Species
is encoded by: hsa:2745
constant: false
initial concentration: NaN

metaR G6Pter
product: MODEL1310110017#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaM HC02207 c
type: Species
is: SBO:0000247
boundary condition: false
name: prostaglandin-c2
constant: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
is: CHEBI:27555
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e1322f2f_a054_4c25_8291_c975350e978f
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10637
is: O75610
has only substance units: false
initial amount: NaN
name: LEFTY1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_b4310443_0342_4425_8fd8_3ca18d4badf7
constant: false
is encoded by: hsa:5730
boundary condition: true
name: PTGDS
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P41222
initial concentration: NaN
type: Species

metaR r2112
type: Reaction
fast: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110017#_a6792eb7_86c1_4fea_8fef_adab57a2389b
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:10637
type: Species
is: O75610
initial amount: NaN
name: LEFTY1
is: SBO:0000252

metaM retn c
is: CHEBI:35291
initial amount: NaN
type: Species
name: all-trans-retinoate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
constant: false

metaR GALASE19ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110017#
is: SBO:0000176

metaM atp n
has only substance units: false
initial concentration: 1.0
is: HMDB00538
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
boundary condition: false
constant: false
type: Species
is: CHEBI:57299
is: SBO:0000247

metaM fol e
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Folate
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
constant: false

metaR r1583
reactant: MODEL1310110017#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaR r0963
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reactant: MODEL1310110017#
reversible: false
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaR r1746
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110017#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_e0a8b2ae_882e_4389_9d0d_b3400262e8c4
is: SBO:0000252
type: Species
name: AOC3
is encoded by: hsa:8639
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q16853
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_b5219dad_646a_45e2_a336_f01b9bfa7d56
constant: false
boundary condition: true
is encoded by: hsa:65263
has only substance units: false
is: SBO:0000252
name: PYCRL
initial concentration: NaN
type: Species
initial amount: NaN
is: Q53H96

metaR r2111
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
is described by: ECO:0000000

metaR RE2349C
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
modifier: MODEL1310110017#
name: RE2349
fast: false
product: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
type: Reaction
is described by: ECO:0000000

metaR NDPK6m
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110017#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
product: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#

metaM retn e
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
boundary condition: false
name: all-trans-retinoate
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01852
initial concentration: 1.0
constant: false
has only substance units: false

metaM HC02207 e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27555
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaM atp m
constant: false
type: Species
is: HMDB00538
has only substance units: false
initial amount: NaN
is: CHEBI:57299
initial concentration: 1.0
name: ATP(4-)
is: C00002
is: SBO:0000247
boundary condition: false

metaM srtn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: serotonin(1+)
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
initial amount: NaN
is: HMDB00259

metaR RE3565C
product: MODEL1310110017#
reversible: true
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3565
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_55978c8b_dbf8_476c_a911_ccc8d13b3ac8
type: Species
name: ACOT6
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:641372
is: SBO:0000252
is: Q3I5F7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_5c71edd3_0b91_41a2_b13a_e38850a0e043
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2879
is: P36969
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: GPX4
has only substance units: false

metaM cdp e
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
constant: false
is: HMDB01546
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58069
name: CDP(3-)
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_df3aab88_53bc_46e4_851f_4d4aefc10b97
is: SBO:0000252
type: Species
is: Q6IBC0
has only substance units: false
constant: false
is encoded by: hsa:3155
initial amount: NaN
name: HMGCL
initial concentration: NaN
boundary condition: true

metaR r1584
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000

metaR RAI2
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
name: retinal isomerase (9-cis)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

metaR HAS1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reversible: false
fast: false
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase

metaR r1429
fast: false
reactant: MODEL1310110017#
reversible: true
name: Free diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
product: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_831f6afb_9c1c_4229_9894_28df14b2af63
has part: P09622
name: DLD:GCSH:GLDC:AMT
has part: P23378
is encoded by: hsa:2731
is encoded by: hsa:1738
has part: P23434
initial amount: NaN
constant: false
is encoded by: hsa:2653
initial concentration: NaN
is encoded by: hsa:275
is: SBO:0000297
boundary condition: true
type: Species
has part: P48728
has only substance units: false

metaR r2114
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#

metaR O2t
name: o2 transport (diffusion)
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reversible: true
fast: false
reactant: MODEL1310110017#

metaM fol c
is: HMDB00121
initial amount: NaN
name: Folate
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247

metaR r1585
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e1715f7f_35a5_4331_8933_13927b4d1a4a
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: O15254
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:8310
name: ACOX3

metaR r0502
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
reversible: true
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_c44f1c22_5a18_4cae_9435_9c04726ce927
constant: false
initial amount: NaN
name: HADH
boundary condition: true
is encoded by: hsa:3033
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q16836
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_0f41652d_1966_4736_b2e8_07f84a5e46b6
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: O15427
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9123
name: SLC16A3
has only substance units: false

metaR RAI1
name: retinal isomerase (11-cis)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176

metaR UMPK3n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: UMP kinase (UTP),nuclear
kinetic law: MODEL1310110017#
is described by: ECO:0000269

metaM dtmp m
is: C00364
is: CHEBI:26999
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: dTMP
is: SBO:0000247
boundary condition: false
is: HMDB01227
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaR SO4t4 2
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000269
fast: false

metaR r1428
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
name: Free diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false

metaR GLYCLTtp
reactant: MODEL1310110017#
is described by: ECO:0000000
name: glycolate transport into peroxisome
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false

metaR r2113
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
is: SBO:0000185
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_32ac4ae8_8593_470b_8a0d_d839c4d56f00
is encoded by: hsa:AA526438
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: _AA526438_1_m

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_dde7495e_48be_4c42_941d_0840ca49944a
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P26439
is encoded by: hsa:3284
name: HSD3B2
constant: false
type: Species
has only substance units: false

metaM srtn e
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:350546
is: HMDB00259
boundary condition: false
has only substance units: false
type: Species
name: serotonin(1+)

metaM bilirub e
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: SBO:0000247
name: bilirubin(2-)
is: HMDB00054

metaR r0580
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
product: MODEL1310110017#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:

metaR r1586
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR VALt5m
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
name: Valine reversible mitochondrial transport
fast: false
reversible: true

metaM h x
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
constant: false
initial amount: NaN

metaM cdp c
name: CDP
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB01546
initial amount: NaN
boundary condition: false
is: CHEBI:58069
is: C00112
initial concentration: 1.0

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR r1630
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
fast: false
type: Reaction

metaM 3pg m
initial amount: NaN
is: CHEBI:58272
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00807
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: SBO:0000247

metaR r0892
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
modifier: MODEL1310110017#
reversible: true
product: MODEL1310110017#
fast: false
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR SO4tl
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
fast: false
is: SBO:0000185
name: Sulfate transport (lysosome)

metaR BAMPPALDOX
fast: false
product: MODEL1310110017#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
modifier: MODEL1310110017#
type: Reaction
reversible: false
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110017#_1391ae75_44b6_4e32_bced_fb585031930c
initial concentration: NaN
is: SBO:0000252
constant: false
name: DGKB
boundary condition: true
type: Species
is encoded by: hsa:1607
has only substance units: false
initial amount: NaN

metaR r0829
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110017#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.1.1.37

metaR PI45P5P
type: Reaction
reversible: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false

metaR NTD10
name: 5'-nucleotidase (XMP)
reactant: MODEL1310110017#
is described by: ECO:0000254
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_2b88e923_cb24_482e_aea1_9fb9acd8d550
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57127
name: RHBG
constant: false
has only substance units: false
is: Q9H310

metaR r2117
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true

metaR GLYt2r
name: glycine reversible transport via proton symport
fast: false
is described by: ECO:0000304
modifier: MODEL1310110017#
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR r1631
kinetic law: MODEL1310110017#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
reversible: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR RE1447N
product: MODEL1310110017#
name: RE1447
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_0e256846_c6c4_4a4b_abda_3dc5cf792000
is: SBO:0000252
constant: false
boundary condition: true
is: P36969
initial concentration: NaN
name: GPX4
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2879

metaR r0377
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reversible: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
fast: false
modifier: MODEL1310110017#
product: MODEL1310110017#

metaM oaa m
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: Oxaloacetate
is: CHEBI:16452
has only substance units: false
is: HMDB00223
is: C00036
initial concentration: 1.0

metaR It
fast: false
modifier: MODEL1310110017#
name: Iodide uniport
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
type: Reaction

metaR r1018
product: MODEL1310110017#
reactant: MODEL1310110017#
name: Transport reaction
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false

metaM asp L c
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
is: SBO:0000247
name: L-aspartate(1-)
is: HMDB00191
type: Species
is: CHEBI:29991
initial concentration: 1.0

metaM thf c
boundary condition: false
is: CHEBI:57453
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: C00101
constant: false
has only substance units: false
is: HMDB01846
type: Species

metaM HC01115 c
boundary condition: false
is: CHEBI:29025
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: NeuNGc
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247

metaR FATP3t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
product: MODEL1310110017#
reversible: true
is described by: ECO:0000269
name: fatty acid electroneutral transport
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_20f913c7_4af4_41e8_901c_4fb2d4d04fd4
is encoded by: hsa:1103
type: Species
name: CHAT
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: D3DX95
constant: false

metaR r2118
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

metaM oxa c
name: oxalate(2-)
initial amount: NaN
boundary condition: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
type: Species
is: CHEBI:30623
has only substance units: false
is: SBO:0000247
constant: false

metaM his L e
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: L-histidine
is: HMDB00177

metaR GUMTCHOLe
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_07b61422_578c_4b9a_b8b2_300a63d0f085
initial concentration: NaN
type: Species
is encoded by: hsa:3421
name: IDH3G
boundary condition: true
has only substance units: false
constant: false
is: E9PDD5
initial amount: NaN
is: SBO:0000252

metaM man1p c
constant: false
initial concentration: 1.0
is: HMDB06330
is: CHEBI:35374
boundary condition: false
name: D-Mannose 1-phosphate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
has only substance units: false

metaM cmpacna g
is: SBO:0000247
boundary condition: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_437918f7_671e_4c15_8255_da56461be872
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: UCKL1
type: Species
constant: false
is: Q53HM1
is encoded by: hsa:54963
initial concentration: NaN

metaM 4h2oglt m
type: Species
name: 4-hydroxy-2-oxoglutarate(2-)
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17742
is: SBO:0000247
initial concentration: 1.0

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR AHCYStr
name: S-Adenosyl-L-homocysteine intracellular diffusion
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR GLYt7 211 r
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reversible: true
modifier: MODEL1310110017#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185

metaM utp c
is: C00075
boundary condition: false
is: HMDB00285
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
initial concentration: 1.0
is: CHEBI:46398
constant: false
name: UTP
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_94e1d8a7_ade7_44f9_a85f_d5dff0a8c33d
is encoded by: hsa:8526
is: A1L4Q0
is: SBO:0000252
boundary condition: true
type: Species
name: DGKE
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM cortsn r
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: cortisone
initial concentration: 1.0
is: HMDB02802
is: CHEBI:16962
is: SBO:0000247
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762

metaR r2329
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_2689cdbc_f184_45fc_bafa_2d8d47ede931
constant: false
is: Q674R7
has only substance units: false
name: ATG9B
boundary condition: true
is encoded by: hsa:285973
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r1418
is described by: ECO:0000000
fast: false
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_4db74190_73ce_42d5_a1e5_8abb9c08105f
initial amount: NaN
constant: false
is: SBO:0000252
is: Q86WU2
is encoded by: hsa:197257
name: LDHD
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM CE5586 c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: CHEBI:58732
initial amount: NaN
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

http://identifiers.org/biomodels.db/MODEL1310110017#_b74e26a0_dff9_4fd4_ad83_269df7f9e357
is encoded by: hsa:55753
boundary condition: true
is: Q9ULD0
constant: false
is: SBO:0000252
has only substance units: false
name: OGDHL
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2115
reactant: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NDPK4m
modifier: MODEL1310110017#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110017#
name: nucleoside-diphosphate kinase (ATP:dTDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_feb47088_99c4_4e93_9b26_e527a136325d
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: _LOC727762_1_m
is encoded by: hsa:LOC727762

metaM succ m
has only substance units: false
initial amount: NaN
is: HMDB00254
is: CHEBI:30031
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: C00042
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaM cala c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00026
is: CHEBI:11892
name: N-carbamoyl-beta-alaninate
has only substance units: false
type: Species
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642

metaM nad x
is: CHEBI:57540
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00902
initial amount: NaN
is: C00003
is: http://identifiers.org/pubchem.compound/3305
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7bdc71d3_1db6_45b8_b872_9faaffaacf10
initial concentration: NaN
has only substance units: false
is: Q8NFF2
is: SBO:0000252
name: SLC24A4
is encoded by: hsa:123041
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR RETI1
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
name: retinol isomerase (11-cis)
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_b2ec47da_023f_41c3_a95e_89b84f1aa88a
name: SLC23A2
is: Q9UGH3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:9962
type: Species
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_d986a55a_bfec_41b4_80ca_6d40bc05d52b
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AI656480
initial amount: NaN
name: _AI656480_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c5a95f2d_c3d7_4081_bc82_c1163023bf08
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AKR1C4
is: P17516
boundary condition: true
type: Species
constant: false
is encoded by: hsa:1109

metaM oxa e
initial amount: NaN
name: oxalate(2-)
is: HMDB02329
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
is: CHEBI:30623
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR r2116
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true

metaR H2O2t
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reactant: MODEL1310110017#
fast: false
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110017#

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR DGSNt
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoyguanosine transport via diffusion
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185

metaM 3hibutcoa m
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: HMDB01052
is: CHEBI:28259
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR EBP1r
modifier: MODEL1310110017#
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
reversible: false
fast: false
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/5.3.3.5
type: Reaction
is described by: ECO:0000134

metaM utp e
is: HMDB00285
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: CHEBI:46398
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: UTP(4-)
is: SBO:0000247

metaM ksii core2 deg6 l
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
is: CHEBI:12936
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6
is: SBO:0000247
has only substance units: false

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM Lkynr c
name: L-kynurenine
has only substance units: false
is: HMDB00684
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16946
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328

metaR PROSTGE2t
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_4e7cc059_0e93_4be3_9578_529cfae173ce
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P30084
is encoded by: hsa:1892
constant: false
has only substance units: false
name: ECHS1

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_f7cb4c9e_422d_4047_b0eb_4161869ec2c2
initial concentration: NaN
is: P17568
constant: false
boundary condition: true
is encoded by: hsa:4713
type: Species
initial amount: NaN
name: NDUFB7
has only substance units: false
is: SBO:0000252

metaM CE5786 e
is: SBO:0000247
is: CHEBI:27485
name: kinetensin
is: HMDB02710
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r2198
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110017#
type: Reaction

metaM 56dthm c
boundary condition: false
is: SBO:0000247
is: CHEBI:27468
is: HMDB00079
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
name: 5,6-dihydrothymine
constant: false

metaR RETI2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reversible: true
product: MODEL1310110017#
fast: false
name: retinol isomerase (9-cis)
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaM ascb L e
has only substance units: false
initial concentration: 1.0
name: L-ascorbate
boundary condition: false
type: Species
constant: false
is: HMDB00044
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
is: SBO:0000247

metaM icit x
is: HMDB00193
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16087
name: isocitrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_b791696f_b244_4043_8538_8fdbc88f110f
is: B3KXN9
initial concentration: NaN
type: Species
initial amount: NaN
name: ADO
is encoded by: hsa:84890
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM xol7ah2 m
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
is: HMDB06893
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_444d64fb_0b55_4626_8aae_98e585cdf1a2
is: Q5MY95
name: ENTPD8
type: Species
is encoded by: hsa:377841
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR RE0830C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
name: RE0830
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR NACDe
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR SQLSr
kinetic law: MODEL1310110017#
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
fast: false
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110017#_f3f5af3c_3ed6_4a63_aefd_116319e96ed4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ACHE
boundary condition: true
is encoded by: hsa:43
type: Species

metaR NMNATr
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
type: Reaction

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction

metaM gsn c
name: Guanosine
is: C00387
initial concentration: 1.0
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:16750
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_43321372_982e_4c3d_920a_4194fe0834d9
initial concentration: NaN
constant: false
is: Q9HC21
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:60386
boundary condition: true
name: SLC25A19
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_ef1e40f3_b060_4d8c_84d0_9ed47b7585d4
name: ALDH1B1
initial amount: NaN
is: SBO:0000252
is: P30837
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:219
type: Species
constant: false

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.16.1
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
modifier: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reversible: false

metaM 5adtststerone c
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
is: HMDB02961
initial amount: NaN
is: CHEBI:16330
type: Species
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
is: SBO:0000247

metaM nadh x
is: SBO:0000247
is: CHEBI:57945
is: HMDB01487
constant: false
name: Nicotinamide adenine dinucleotide - reduced
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
initial amount: NaN

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_849e5bbf_7850_4b82_8bbe_9801612f9600
name: AMY2A
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:279
constant: false
is: P04746
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_0d679f80_848b_4035_8eaa_72f892a36ac4
is: P09923
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ALPI
is encoded by: hsa:248
constant: false

metaR PYRt2m
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
is: SBO:0000185
type: Reaction
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000

metaR r1632
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_95b331ff_3467_42d2_b236_3486d328f420
is: P09622
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1738
constant: false
initial amount: NaN
name: DLD

metaM ctp m
is: CHEBI:37563
boundary condition: false
name: CTP(4-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00082

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
reversible: true
name: isoleucine transaminase, mitochondrial
product: MODEL1310110017#

metaR r2119
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true

metaR NH4t3r
modifier: MODEL1310110017#
name: ammonia transport via proton antiport
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is: SBO:0000185

metaR r2196
modifier: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM 5adtststerone e
is: SBO:0000247
boundary condition: false
is: HMDB02961
initial amount: NaN
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
has only substance units: false
is: CHEBI:16330
type: Species

metaM ascb L c
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
is: HMDB00044
initial amount: NaN
has only substance units: false
name: L-ascorbate
is: CHEBI:38290
is: SBO:0000247

metaR r1633
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1377
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110017#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaM malthx e
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
constant: false
is: C01936
has only substance units: false
name: Maltohexaose
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false

metaM ctp n
initial concentration: 1.0
initial amount: NaN
is: HMDB00082
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
name: CTP(4-)
type: Species
is: CHEBI:37563
is: SBO:0000247
boundary condition: false

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_569c106e_b535_485a_af49_2ef012baf5b5
constant: false
boundary condition: true
has only substance units: false
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_84956454_6fd1_496a_bafe_d6a46bf5bc35
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:AA419122
name: _AA419122_1_c
initial amount: NaN

metaM crtsl r
is: SBO:0000247
initial concentration: 1.0
name: cortisol
is: CHEBI:17650
type: Species
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
initial amount: NaN
is: HMDB00063
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e0feef4f_9385_45a0_ac4f_5f8ea69e5115
type: Species
is encoded by: hsa:10965
is: P49753
boundary condition: true
name: ACOT2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR r2195
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM itaccoa m
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57381
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
is: HMDB03377
name: itaconyl-CoA(5-)

metaR r2323
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM 4fumacac c
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:18034
boundary condition: false
initial amount: NaN
name: 4-fumarylacetoacetate(2-)
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: HMDB01268
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c45a2dff_6ad0_49e8_b5db_93e3b7c4bffe
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI926493
is: SBO:0000252
type: Species
name: _AI926493_1_m

metaR RE0830N
type: Reaction
is: SBO:0000176
name: RE0830
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000

metaR r0483
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110017#
reversible: true
product: MODEL1310110017#

metaR GLYCtm
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110017#
name: glycerol transport
product: MODEL1310110017#

metaR FUMSO4tm
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
name: glyceraldehyde-3-phosphate dehydrogenase
kinetic law: MODEL1310110017#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.

http://identifiers.org/biomodels.db/MODEL1310110017#_30a52088_1f25_4c89_a568_6f236a619ea6
boundary condition: true
initial concentration: NaN
is: O95436
initial amount: NaN
type: Species
name: SLC34A2
is encoded by: hsa:10568
constant: false
has only substance units: false
is: SBO:0000252

metaR r2324
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

metaM lnlccrn c
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: Linoleyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
has only substance units: false
is: HMDB06469

metaR URIDK2m
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
fast: false
name: uridylate kinase (dUMP), mitochondrial
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110017#
is: SBO:0000176
reversible: true

metaR HYXNt
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
fast: false
type: Reaction
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: Hypoxanthine transport

metaR THYOXt2
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
name: T4 transport via facilitated diffusion
modifier: MODEL1310110017#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110017#

metaM nad r
type: Species
name: NAD(1-)
is: CHEBI:57540
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
initial concentration: 1.0

metaM Lpipecol x
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid
is: SBO:0000247
initial amount: NaN
is: CHEBI:30913
boundary condition: false
constant: false
is: HMDB00716

metaM HC02179 c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:34306
constant: false
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0

metaR r1492
reversible: false
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
product: MODEL1310110017#
name: Utilized transport

metaR r2321
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110017#_b262647f_c31a_4631_a926_284c2dd21282
initial amount: NaN
has only substance units: false
is: P12235
name: SLC25A4
constant: false
is encoded by: hsa:291
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM 6dhf e
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: SBO:0000247
is: HMDB06563
name: hexaglutamyl folate (DHF)
has only substance units: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_eae2d877_d15b_42d8_8be5_cd20b54a6a4e
is encoded by: hsa:79695
initial concentration: NaN
name: GALNT12
is: Q8IXK2
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM vitd3 e
constant: false
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
is: HMDB00876
type: Species
name: calciol
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28940

http://identifiers.org/biomodels.db/MODEL1310110017#_2dc9a73c_044a_4194_9e75_30e20c43b043
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA788780
boundary condition: true
name: _AA788780_1_c

metaR r2322
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_761660cd_0dfb_4e1f_addf_b04127c17294
is encoded by: hsa:6509
name: SLC1A4
initial concentration: NaN
is: P43007
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR PETOHMm hs
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: phosphatidylethanolamine N-methyltransferase
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110017#_2dd46d5d_4e6f_46e5_ad02_8197b4326c50
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q9NS82
has only substance units: false
is encoded by: hsa:56301
initial concentration: NaN
boundary condition: true
name: SLC7A10

metaR PYRt2r
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110017#
fast: false
name: pyruvate reversible transport via proton symport
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is: SBO:0000185
product: MODEL1310110017#

metaM 3pg c
constant: false
name: 3-Phospho-D-glycerate
has only substance units: false
initial amount: NaN
is: C00197
is: HMDB00807
is: SBO:0000247
type: Species
is: CHEBI:58272
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497

metaR G5SADrm
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110017#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

http://identifiers.org/biomodels.db/MODEL1310110017#_fe86436e_4925_4842_9bd0_e0e1b4b20298
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
has only substance units: false
initial concentration: NaN
type: Species
has part: Q86U05

http://identifiers.org/biomodels.db/MODEL1310110017#_1e6cde51_0b9d_47b3_becd_5928ce150d3a
has only substance units: false
is encoded by: hsa:2731
boundary condition: true
is: P23378
initial concentration: NaN
name: GLDC
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaM oaa c
is: HMDB00223
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: C00036
initial amount: NaN
is: SBO:0000247
is: CHEBI:3338
name: Oxaloacetate

metaM r5p c
constant: false
is: C00117
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: CHEBI:18189
is: SBO:0000247
is: HMDB00618
boundary condition: false
has only substance units: false
name: alpha-D-Ribose 5-phosphate

http://identifiers.org/biomodels.db/MODEL1310110017#_ad73d01a_1dee_4efd_98f2_7f5ce5467f67
is: SBO:0000252
has only substance units: false
boundary condition: true
name: RRM2
type: Species
is encoded by: hsa:6241
initial concentration: NaN
constant: false
is: P31350
initial amount: NaN

metaM thf m
is: C00101
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57453
is: HMDB01846
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_9430b172_e1f0_488b_87f3_2a358e418e0e
type: Species
name: COX7A2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1347
constant: false
has only substance units: false
is: H0UI06
initial amount: NaN
boundary condition: true

metaR r0022
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
modifier: MODEL1310110017#
product: MODEL1310110017#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false

metaM HC02179 e
has only substance units: false
initial amount: NaN
is: CHEBI:34306
name: 20-hydroxy-arachidonate
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0

metaM succ e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:30031
name: succinate(2-)
constant: false
is: HMDB00254
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_344e2852_1a41_4195_8975_b9f141117f8c
is: SBO:0000252
is encoded by: hsa:1349
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: COX7B
initial concentration: NaN
is: P24311

metaM nad m
name: Nicotinamide adenine dinucleotide
is: C00003
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
constant: false
is: HMDB00902

metaM crm hs c
has only substance units: false
is: CHEBI:52639
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
name: N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110017#_58802109_c28b_4772_95c1_530ebeee2770
type: Species
initial concentration: NaN
is encoded by: hsa:8883
boundary condition: true
constant: false
name: NAE1
is: SBO:0000252
is: A8MU28
initial amount: NaN
has only substance units: false

metaR r0408
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
modifier: MODEL1310110017#
product: MODEL1310110017#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
reactant: MODEL1310110017#

metaR r2327
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_90de301e_0cd9_4a73_8ca9_1a66df94be55
initial concentration: NaN
is encoded by: hsa:7941
boundary condition: true
type: Species
constant: false
name: PLA2G7
is: SBO:0000252
initial amount: NaN
is: Q13093
has only substance units: false

metaM xol7ah2 c
constant: false
initial amount: NaN
is: CHEBI:28047
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
name: 5beta-cholestane-3alpha,7alpha-diol
type: Species
initial concentration: 1.0
is: HMDB06893
boundary condition: false

metaM tag hs c
type: Species
name: triglyceride
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17855

metaR GLCAASE8ly
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: false
name: beta-glucuronidase, lysosomal
fast: false

metaM 6pgc r
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
constant: false
is: SBO:0000247
is: CHEBI:58759
boundary condition: false
initial concentration: 1.0
name: 6-phosphonatooxy-D-gluconate
is: HMDB01316

metaM 42A3HP24DB c
is: C05645
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7956
is: HMDB04083

metaM 6dhf c
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB06563
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e2826705_bd73_4b79_9f8b_29f2232ee0f8
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HSD17B4
is encoded by: hsa:3295
is: E9PB82

metaR CSND
name: Cytosine deaminase
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
reversible: false
reactant: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine

metaR ACOX22x
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
fast: false
type: Reaction
product: MODEL1310110017#
name: acyl-Coenzyme A oxidase 2, branched chain
is version of: http://identifiers.org/ec-code/1.17.99.3
is described by: ECO:0000304
modifier: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ

metaR GCALDD
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
name: Glycolaldehyde dehydrogenase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
modifier: MODEL1310110017#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_095dc196_4e4b_45ca_8048_7694191c9683
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: Q86SR1
name: GALNT10
is: SBO:0000252
is encoded by: hsa:55568

metaR PIt7
type: Reaction
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185
fast: false
reversible: true

metaR ILEt5m
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
is: SBO:0000185
name: Isoleucine mitochondrial transport
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_5b89bccc_22fc_47da_a301_c4247de93fbf
name: _NOS2A_1_e
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:NOS2A
type: Species
constant: false
boundary condition: true

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM lnlc e
has only substance units: false
constant: false
is: CHEBI:30245
is: HMDB00673
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM ak2lgchol hs e
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false
has only substance units: false
constant: false
is: C04317
type: Species
initial amount: NaN
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: SBO:0000247
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

http://identifiers.org/biomodels.db/MODEL1310110017#_6c66c008_566f_4c90_80b0_5ecd3d8dc7c5
is: SBO:0000252
is encoded by: hsa:4830
initial amount: NaN
type: Species
has only substance units: false
name: NME1
constant: false
initial concentration: NaN
boundary condition: true

metaM cmpacna c
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
has only substance units: false

metaR r2325
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR NADS2
fast: false
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.3.5.1
modifier: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
type: Reaction
reversible: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR HSD3A2r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
modifier: MODEL1310110017#
reversible: true

metaM tag hs e
is: SBO:0000247
name: triglyceride
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
constant: false
boundary condition: false
is: CHEBI:17855
initial concentration: 1.0
initial amount: NaN

metaR r1862
reactant: MODEL1310110017#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR r0027
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110017#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
reactant: MODEL1310110017#
reversible: true

metaM T antigen g
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false
is: CHEBI:22783
name: T antigen (core 1)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5caf95fb_507a_44ad_a435_b5c1a474fd30
initial concentration: NaN
is: Q92523
is encoded by: hsa:1375
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: CPT1B
type: Species

metaR NAHCO3 HCLt
modifier: MODEL1310110017#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110017#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is: SBO:0000185

metaM icit m
boundary condition: false
is: HMDB00193
constant: false
is: CHEBI:16087
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
name: Isocitrate
initial concentration: 1.0
initial amount: NaN
type: Species

metaR PIt8
modifier: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000006
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: phosphate transport in/out via Na+ symporter

metaR ACHtn
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
name: Acetylcholin transport, nuclear trhough pores
reactant: MODEL1310110017#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110017#_048cf895_a8b7_4806_8df4_7a8cc17800d7
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC35D1
is: Q9NTN3
boundary condition: true
constant: false
is encoded by: hsa:23169
initial amount: NaN

metaM his L c
name: L-histidine
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB00177
initial amount: NaN

metaR r2326
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
fast: false
is: SBO:0000185

metaM nadh r
type: Species
is: SBO:0000247
is: HMDB01487
is: CHEBI:57945
name: NADH(2-)
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial amount: NaN
initial concentration: 1.0

metaM utp n
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
type: Species
is: CHEBI:46398
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00285

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
name: choline phosphatase

metaR r0407
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaR r2042
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
modifier: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
reversible: false
type: Reaction

metaR LPCOXp
kinetic law: MODEL1310110017#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
modifier: MODEL1310110017#
name: L-pipecolate oxidase, peroxisomal
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.3.1
fast: false
is: SBO:0000176

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_b4d09d09_e017_4a08_857a_9ab63abcbd26
boundary condition: true
name: AMY1A
is: SBO:0000252
is: Q6NSB3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:276
type: Species
initial amount: NaN
constant: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_35c7a0dc_1f3b_4d92_87bc_8e923417ed90
name: SLC25A2
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9BXI2
is encoded by: hsa:83884

http://identifiers.org/biomodels.db/MODEL1310110017#_b10bf8fa_59bb_4ed1_9025_f6f80ec32abd
constant: false
has only substance units: false
is: Q9NYQ3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: HAO2
type: Species
boundary condition: true
is encoded by: hsa:51179

metaR r0139
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110017#
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR VD3
name: Vitamin D3 formation
is described by: ECO:0000134
fast: false
product: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

metaM nh4 c
is: SBO:0000247
boundary condition: false
is: HMDB00051
type: Species
constant: false
name: Ammonium
has only substance units: false
is: C01342
initial concentration: 1.0
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_9b797f85_0317_4df8_8554_7d8a846c8016
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80308
is: SBO:0000252
constant: false
initial amount: NaN
name: FLAD1

metaM lnlc c
boundary condition: false
is: CHEBI:30245
has only substance units: false
type: Species
name: linoleate
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_270afeac_18ba_48d9_b183_6acb1401c9a4
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:60482
name: SLC5A7
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q9GZV3

metaR NADtx
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110017#
fast: false
name: transport of NAD into peroxisome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_9ca7e657_8c24_4a13_b656_c15fb76e349e
boundary condition: true
initial concentration: NaN
name: ASNS
initial amount: NaN
is: P08243
has only substance units: false
is: SBO:0000252
is encoded by: hsa:440
type: Species
constant: false

metaR ALADGLNexR
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_3d59be39_3e6f_4801_8cb7_f596177c5756
constant: false
name: NDUFC2
is: SBO:0000252
is: Q549M5
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4718

metaR RE0691C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
name: RE0691
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM csn e
is: HMDB00630
initial concentration: 1.0
name: cytosine
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16040
constant: false
type: Species

metaM zymst r
is: HMDB06271
is: CHEBI:18252
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: zymosterol

metaR SERGLNexR
product: MODEL1310110017#
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
modifier: MODEL1310110017#

metaR PUNP7
name: purine-nucleoside phosphorylase (Xanthosine)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110017#_e8a80d77_b8a3_4915_b158_3baaf4b9c718
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:19
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: O95477
name: ABCA1
type: Species

metaM nh4 e
name: ammonium
boundary condition: false
is: HMDB00051
is: CHEBI:28938
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR MAL Lte
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Transport of L-malate

metaR UAG4E
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110017#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
modifier: MODEL1310110017#
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110017#
is described by: ECO:0000304
reactant: MODEL1310110017#

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_8ce959e1_4229_425d_9c1f_cc7591bbdf93
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AA081045_1_c
is encoded by: hsa:AA081045
type: Species
boundary condition: true
is: SBO:0000252

metaR r1380
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_d98e0438_39be_49c8_964a_53fb38fceebd
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:55350
name: VNN3
initial concentration: NaN
boundary condition: true
constant: false

metaR BHBt
product: MODEL1310110017#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaR RE1522M
is: SBO:0000176
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1522
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
fast: false

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM nadh m
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
is: C00004
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR RE1342C
is described by: ECO:0000000
reactant: MODEL1310110017#
name: RE1342
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
fast: false
type: Reaction
product: MODEL1310110017#
is: SBO:0000176

metaM q10h2 c
constant: false
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
is: SBO:0000247
name: Ubiquinol-10
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

http://identifiers.org/biomodels.db/MODEL1310110017#_d6ca5fb6_f71e_4645_b7ba_fdf3966f37db
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q9H2X9
is: SBO:0000252
boundary condition: true
name: SLC12A5
is encoded by: hsa:57468

metaR GLYtp
name: glycine passive transport to peroxisome
kinetic law: MODEL1310110017#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

metaR SUCCt4 2
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
fast: false
reversible: true
product: MODEL1310110017#
name: succinate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD

metaR FADtx
name: FAD transporter, peroxisomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_32ee51e1_cc41_4125_b561_4e95d2e116f0
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: SLC18A1
constant: false
is: Q96GL6
is encoded by: hsa:6570
is: SBO:0000252

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM csn c
initial concentration: 1.0
is: SBO:0000247
name: cytosine
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
type: Species
initial amount: NaN
is: CHEBI:16040
constant: false
boundary condition: false
is: HMDB00630
has only substance units: false

metaM CE4872 c
type: Species
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
constant: false
is: HMDB00127
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15748

metaM adn c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:16335
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
is: HMDB00050
name: Adenosine
is: C00212

metaR THYOXt
name: T4 transport via bicarbonate countertransport
fast: false
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_60d7d7de_2992_4beb_8de6_71e7cec5ea28
boundary condition: true
is encoded by: hsa:51109
is: SBO:0000252
name: RDH11
is: B4DDW0
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR PUNP5
type: Reaction
name: purine-nucleoside phosphorylase (Inosine)
is described by: ECO:0000269
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true

metaR r1177
is described by: ECO:0000000
product: MODEL1310110017#
name: EC:3.1.1.13
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ae1c409b_c52d_47b6_a1de_5ef0ba9712e8
is: F5H2Y9
type: Species
boundary condition: true
constant: false
is encoded by: hsa:8854
has only substance units: false
initial concentration: NaN
name: ALDH1A2
initial amount: NaN
is: SBO:0000252

metaR GLYtm
reversible: true
type: Reaction
is described by: ECO:0000000
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_b045c581_28e8_4609_910c_da7e9b9ed4c6
constant: false
type: Species
is: P50213
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: IDH3A
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3419

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_ac052eee_c4da_442e_98ae_22599b00fbc8
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI191472
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AI191472_1_c

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM q10h2 e
is: HMDB13111
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false

metaM triodthy e
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:18258
has only substance units: false
type: Species

metaM 6dhf m
type: Species
constant: false
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM Lcystin c
is: HMDB00192
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: L-cystine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c0dace62_c4a5_4e98_af63_6db560f8dc6f
is: SBO:0000252
initial concentration: NaN
is: Q99714
initial amount: NaN
name: HSD17B10
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:3028
type: Species

metaR UMPK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
name: UMP kinase (GTP),nuclear
fast: false
type: Reaction

metaR RE3347C
product: MODEL1310110017#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
type: Reaction
name: RE3347
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_b3717823_9532_4cfb_ad5d_0fc0def2df33
name: TRNT1
is encoded by: hsa:51095
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q96Q11
type: Species
boundary condition: true

MODEL1310110017
reaction: metaR 5ADTSTSTERONEte
species: metaM 4hpro LT e
reaction: metaR SPC HSt
species: metaM CE5786 e
reaction: metaR r0170
species: metaM xan c
reaction: metaR r0642
reaction: metaR EX dchac LPAREN e RPAREN
reaction: metaR r1544
reaction: metaR r0408
species: metaM 2mp2coa m
species: metaM hxan e
species: metaM udp r
reaction: metaR r1606
reaction: metaR EX C04849 LPAREN e RPAREN
reaction: metaR NORANMT
species: metaM 5mthf c
reaction: metaR ALDD2xm
species: metaM pi e
reaction: metaR CO2t
reaction: metaR r1910
species: metaM 4fumacac c
reaction: metaR EX cit LPAREN e RPAREN
reaction: metaR PTPATe
reaction: metaR FADH2ETC
reaction: metaR r2325
reaction: metaR EX gln L LPAREN e RPAREN
reaction: metaR r0774
species: metaM so3 c
reaction: metaR DM dsT antigen g
reaction: metaR ALADGLNexR
reaction: metaR r1637
reaction: metaR r2443
species: metaM thp2c x
reaction: metaR r1629
species: metaM gdpmann c
reaction: metaR PGK
reaction: metaR r1559
reaction: metaR GLYt4
species: metaM hpyr c
reaction: metaR r0186
species: metaM o2s e
species: metaM asn L e
reaction: metaR DM datp m
species: metaM nadp r
reaction: metaR RE1898C
species: metaM HC00591 c
reaction: metaR r0083
reaction: metaR NACHEX27ly
species: metaM cmp c
species: metaM co2 c
reaction: metaR r0974
reaction: metaR DALAt2r
reaction: metaR EX pyr LPAREN e RPAREN
reaction: metaR EX maltttr LPAREN e RPAREN
species: metaM oh1 e
species: metaM HC01496 m
reaction: metaR ADK3
reaction: metaR r2095
reaction: metaR r0113
species: metaM s7p c
reaction: metaR 7DHCHSTEROLtr
reaction: metaR r0399
reaction: metaR EX 11 cis retfa LPAREN e RPAREN
reaction: metaR PGLYCt
species: metaM 6dhf l
species: metaM gchola e
species: metaM HC01162 c
reaction: metaR CYTK7
species: metaM HC02217 e
species: metaM accoa c
reaction: metaR r0647
species: metaM leuktrD4 c
reaction: metaR r1581
reaction: metaR ADKd
species: metaM dnad c
reaction: metaR r1722
species: metaM 3hmp m
reaction: metaR UMPK
reaction: metaR ABTti

http://identifiers.org/biomodels.db/MODEL1310110017#_6d72f0d9_5eee_4ce9_84c2_01c2e702708f
is: SBO:0000252
constant: false
has only substance units: false
is: P54819
name: AK2
type: Species
is encoded by: hsa:204
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM glyald c
is: CHEBI:17378
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: C00577
has only substance units: false
constant: false
name: D-Glyceraldehyde
is: SBO:0000247
initial amount: NaN
is: HMDB01051
type: Species
initial concentration: 1.0

metaM dgtp c
is: C00286
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species
initial amount: NaN
is: CHEBI:16497
is: SBO:0000247
has only substance units: false
is: HMDB01440
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_b828d2fb_21ee_415a_9da8_46c916c1d2d0
is: O95573
type: Species
name: ACSL3
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2181

metaR ADK1
name: adenylate kinase
reactant: MODEL1310110017#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaM 6dhf l
initial concentration: 1.0
boundary condition: false
constant: false
name: hexaglutamyl folate (DHF)
is: HMDB06563
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1

metaM pe hs m
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
is: CHEBI:16038
initial concentration: 1.0
initial amount: NaN
type: Species
name: phosphatidylethanolamine
boundary condition: false
is: SBO:0000247

metaR r2332
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_8f9fd629_a3ff_4554_8b48_507cc2e025b9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:65263
type: Species
has only substance units: false
name: PYCRL
constant: false
initial amount: NaN
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110017#_8a29fc57_e2fd_4c88_9038_3af5b3be21ed
name: DGKB
is encoded by: hsa:1607
type: Species
is: Q9Y6T7
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR PROSTGF2t
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
is: SBO:0000185
kinetic law: MODEL1310110017#

metaM HC00250 e
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: hydrosulfide
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM accoa n
type: Species
name: acetyl-CoA(4-)
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial concentration: 1.0
is: HMDB01206
is: CHEBI:57288
initial amount: NaN

metaR r0627
product: MODEL1310110017#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110017#

metaM 13 cis retn r
type: Species
has only substance units: false
is: HMDB06219
constant: false
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
boundary condition: false
is: D00348
initial amount: NaN
is: SBO:0000247

metaR PUNP3
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM ksii core2 deg9 l
type: Species
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: CHEBI:12936
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 9
is: SBO:0000247
is: HMDB00143
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c92be46e_f277_4d32_acb5_425a763e2ce0
initial concentration: NaN
name: PYCR1
is: A6NFM2
initial amount: NaN
boundary condition: true
is encoded by: hsa:5831
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaR ACACT10m
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
modifier: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110017#
reversible: true

metaM xan c
type: Species
name: Xanthine
is: C00385
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
has only substance units: false
is: CHEBI:17712
constant: false
initial concentration: 1.0
is: HMDB00292
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_b0273d60_53d3_4a29_82ab_3b2b0e40acc7
initial amount: NaN
type: Species
name: SDHB
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6390
is: P21912

metaR r0033
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is: SBO:0000176
reactant: MODEL1310110017#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
type: Reaction
fast: false
reversible: false
product: MODEL1310110017#

metaR NORANMT
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
modifier: MODEL1310110017#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
is described by: ECO:0000269
name: noradrenaline N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.28

metaM lthstrl r
is: HMDB01170
has only substance units: false
type: Species
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168
constant: false
initial amount: NaN

metaM Lcystin e
is: CHEBI:16283
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
has only substance units: false
initial amount: NaN
name: L-cystine
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r0400
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_593a911d_d537_4ed2_96e1_9ce7cf58981f
initial amount: NaN
constant: false
name: IDH1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3417
type: Species
has only substance units: false
is: O75874

metaR PUNP1
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110017#
fast: false
name: purine-nucleoside phosphorylase (Adenosine)
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: true

metaM ha deg1 l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16336
name: hyaluronan degradation product 1
boundary condition: false
constant: false

metaR CDSm
name: phosphatidate cytidylyltransferase
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.7.41
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: false

metaR CYTK9n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_df274d26_0d38_41f4_8811_1843bab52799
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: DEGS1
type: Species
is encoded by: hsa:8560

metaR H2O2tp
reversible: true
product: MODEL1310110017#
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD

metaR NACHEX27ly
kinetic law: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110017#
is described by: ECO:0000269
fast: false

metaR r2331
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
fast: false

metaM dttp m
is: CHEBI:37568
constant: false
is: C00459
is: HMDB01342
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
has only substance units: false
name: dTTP
type: Species
is: SBO:0000247

metaM HC00319 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:30794
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR MCPST
is: SBO:0000176
type: Reaction
name: 3-mercaptopyruvate sulfurtransferase
kinetic law: MODEL1310110017#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
is version of: http://identifiers.org/ec-code/2.8.1.2
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: false
product: MODEL1310110017#

metaM accoa m
is: CHEBI:57288
is: C00024
is: SBO:0000247
name: Acetyl-CoA
boundary condition: false
constant: false
is: HMDB01206
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
type: Species

metaR PUNP2
product: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyadenosine)
type: Reaction
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM pect e
initial concentration: 1.0
is: HMDB03402
name: pectins
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C2535H3509O2535 CHARGE: -1
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_276006d6_e596_42ce_97b0_eeced93b2111
name: _AU149534_1_e
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AU149534
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_0b21d5ec_2f4e_4f54_971b_10e054de4ed0
name: _AI915649_1_c
is encoded by: hsa:AI915649
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_3449762a_ee73_4e25_9532_b8a57622443b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:51166
type: Species
is: Q8N5Z0
constant: false
name: AADAT
boundary condition: true

metaM pacald c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
is: HMDB06236
is: CHEBI:16424
type: Species
name: phenylacetaldehyde

metaM dgtp e
boundary condition: false
type: Species
name: dGTP
initial amount: NaN
is: SBO:0000247
is: CHEBI:16497
is: HMDB01440
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR URATEt
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
name: urate export from cytosol
type: Reaction
product: MODEL1310110017#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR ADK3
reversible: true
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
name: adentylate kinase (GTP)
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110017#_27d93c85_c833_4246_bf13_f9992c240ce8
is: SBO:0000252
initial concentration: NaN
type: Species
name: SYNJ1
has only substance units: false
is encoded by: hsa:8867
is: O43426
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c30441bc_10a2_427d_ac34_88e7c2f0f176
initial concentration: NaN
is encoded by: hsa:AL048840
initial amount: NaN
has only substance units: false
constant: false
name: _AL048840_1_c
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_674eab0e_9a31_4235_b825_5e85c9b4d039
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: P15531
constant: false
has only substance units: false
is encoded by: hsa:4830
name: NME1
is: SBO:0000252

metaR r1302
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
name: Vesicular transport

metaR RETHe
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
name: retinyl ester hydrolase, extracellular
reactant: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5ee69e68_92b9_49cf_9d36_c4ac5616f6ab
has only substance units: false
is: P07864
name: LDHC
constant: false
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM C05957 r
constant: false
is: SBO:0000247
boundary condition: false
name: Prostaglandin J2
initial concentration: 1.0
is: CHEBI:27485
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02710
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957

metaR SPODM
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110017#
name: superoxide dismutase
reactant: MODEL1310110017#
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176

metaR r2330
fast: false
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction

metaR H2O2tm
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
name: hydrogen peroxide mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it

metaR AHCYStd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
name: diffusion of S-Adenosyl-L-homocysteine
is described by: ECO:0000134
product: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_7907981f_668b_4805_ace1_0d5e8be0e086
name: NDUFB9
is: Q9Y6M9
is encoded by: hsa:4715
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_87bf4394_f97d_4480_aa3a_0217f5cf5ea4
boundary condition: true
initial concentration: NaN
is: P25325
constant: false
name: MPST
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4357
type: Species
initial amount: NaN

metaR G6PDH2rer
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110017#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
product: MODEL1310110017#

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: beta-galactosidase, lysosomal
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110017#_85515eb4_eb30_472d_97f4_f5d8a6661c9b
constant: false
is: P43353
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:221
name: ALDH3B1
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_5e0240e9_c6a0_43b8_beaf_dddacfa4e8e0
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: _U37519_1_m
initial concentration: NaN
is encoded by: hsa:U37519

metaR H2O2tn
name: hydrogen peroxide nuclear transport
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
is: SBO:0000185

metaR r1301
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reversible: false
name: Vesicular transport
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaM xol7a r
is: SBO:0000247
is: CHEBI:1296
name: 20-hydroxycholesterol
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: HMDB01496
initial concentration: 1.0

metaM 3dhguln c
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
type: Species
is: SBO:0000247
is: HMDB06334
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57655
name: 3-dehydro-L-gulonate

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r1527
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_35679c1d_0c81_4d53_9c76_6eeb23aafea4
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3420
is: SBO:0000252
name: IDH3B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_603be264_528e_4723_a6c8_2ef20aec045c
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1119
boundary condition: true
name: CHKA
is: SBO:0000252
has only substance units: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR GLCURter
is described by: ECO:0000000
product: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
name: glucuronate endoplasmic reticular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM xu5p D c
is: HMDB00868
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false
is: CHEBI:57737
type: Species
initial amount: NaN
name: D-xylulose 5-phosphate(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaM progly c
is: HMDB11178
name: L-Prolinylglycine
type: Species
notes: FORMULA: C7H12N2O3 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM nh4 m
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
is: CHEBI:28938
type: Species
boundary condition: false
is: HMDB00051
constant: false
has only substance units: false
initial concentration: 1.0
is: C01342
initial amount: NaN

metaR r2122
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
is described by: ECO:0000000
reversible: true

metaR CYTDtm
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
fast: false
modifier: MODEL1310110017#
name: cytidine facilated transport in mitochondria

metaM succ x
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
initial concentration: 1.0
is: HMDB00254
initial amount: NaN
boundary condition: false
is: CHEBI:30031
has only substance units: false
is: C00042
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_b753bec1_e90b_427b_b8f5_c7f0ab6fca65
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q5SPY7
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:954
name: ENTPD2
constant: false

metaR r2193
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r1639
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110017#

metaM dgmp e
is: CHEBI:57673
has only substance units: false
is: HMDB01044
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
type: Species
initial concentration: 1.0
name: dGMP(2-)

metaM 5mthf c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00440
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: HMDB01396
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9e8e2393_7f34_4757_87fd_d05fef1ca876
is encoded by: hsa:5092
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: PCBD1
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110017#_1c09d435_5cdc_4e4d_a0f2_c8c7f8f0c310
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q6NVY1
name: HIBCH
constant: false
boundary condition: true
is encoded by: hsa:26275
type: Species
initial concentration: NaN

metaR r0973
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Facilitated diffusion
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_37d03d28_bd41_4e5b_85a6_18c0b2d89826
name: SUCLG2:SUCLG1
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
boundary condition: true
has part: Q96I99
type: Species
has part: P53597
has only substance units: false
is encoded by: hsa:8801
is encoded by: hsa:8802
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ddfca2d3_98c4_48e4_a1b3_90ec2e76e417
type: Species
constant: false
name: _AA526438_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA526438
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2121
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#

metaM g3p c
boundary condition: false
is: CHEBI:58027
is: http://identifiers.org/pubchem.compound/3930
is: SBO:0000247
name: Glyceraldehyde 3-phosphate
type: Species
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
is: HMDB01112
has only substance units: false
initial concentration: 1.0
is: C00661

metaR r0517
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
type: Species
name: ammonium
is: HMDB00051
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r2194
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
type: Reaction
reversible: true

metaR GLU5SAtmc
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
name: glutamate semi-aldehyde transport, mitochondrial
fast: false
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.

metaR r1638
modifier: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110017#_86078810_f993_4eeb_ade2_c9c000e45635
boundary condition: true
initial amount: NaN
is encoded by: hsa:375056
name: MIA3
is: Q5JRA6
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR DNDPt23m
modifier: MODEL1310110017#
name: dTDP transport via dGTP antiport
fast: false
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000269

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_1fb4cdb3_0608_475f_a9fe_01fe9fa2bd3d
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: _BF195998_1_x
has only substance units: false
is encoded by: hsa:BF195998
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_1d959721_a77d_4047_abb4_ee99d5bedfd1
constant: false
is: SBO:0000252
is: Q8IWX5
is encoded by: hsa:130367
initial amount: NaN
has only substance units: false
name: SGPP2
type: Species
boundary condition: true
initial concentration: NaN

metaR ARACHDt2
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR HISCAT1
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r0142
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reversible: false
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110017#

metaR r0974
name: Active transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
type: Reaction
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_396c2eea_95a2_4c5b_9078_f9f28fc519bf
initial concentration: NaN
boundary condition: true
name: SCD5
constant: false
is: Q86SK9
type: Species
is encoded by: hsa:79966
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0629
fast: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.22
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
reactant: MODEL1310110017#

metaR NH4tp
name: ammonia peroxisomal transport
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_008b4795_3b60_4c3f_ae41_e56a8b2963ee
initial amount: NaN
type: Species
is: Q9UHI5
constant: false
boundary condition: true
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000252
name: SLC7A8
initial concentration: NaN

metaM HC00250 c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:29919
name: hydrosulfide
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
initial concentration: 1.0

metaR r2120
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_c8f2e446_e142_498a_a6cc_605d65938bcd
is: SBO:0000252
has only substance units: false
is: O95045
boundary condition: true
is encoded by: hsa:151531
constant: false
initial concentration: NaN
name: UPP2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_9ca800db_db9e_4e6e_9ab2_07ba076f01ef
initial concentration: NaN
boundary condition: true
constant: false
name: COX8A
is encoded by: hsa:1351
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: Q53XN1

metaM dgmp c
is: CHEBI:57673
name: dGMP
is: HMDB01044
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00362
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false

metaR HPYRDC
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
type: Reaction
name: hydroxypyruvate decarboxylase

metaR r1637
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110017#
type: Reaction
reversible: true

metaR r1599
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM 5mthf e
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3729
has only substance units: false
constant: false
is: HMDB01396
name: 5-Methyltetrahydrofolate
is: C00440
type: Species

metaM pe hs c
type: Species
has only substance units: false
initial concentration: 1.0
name: phosphatidylethanolamine
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16038
constant: false

metaR r0899
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
type: Reaction

metaM HC02023 r
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:46898
has only substance units: false
name: Cholesterol-ester-ol
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_608f07a5_e9cc_441a_a9d0_83a36d3adc95
name: AKR1A1
boundary condition: true
is encoded by: hsa:10327
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P14550
is: SBO:0000252

metaR DTMPK
reversible: true
modifier: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: dTMP kinase
type: Reaction
kinetic law: MODEL1310110017#
fast: false

metaR TYRPHELAT2tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r0384
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false

metaR r1636
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
reversible: true
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_1c681c35_d7e5_4a9c_8a4b_3d86a24d8712
boundary condition: true
is encoded by: hsa:51102
initial concentration: NaN
has only substance units: false
type: Species
name: MECR
is: SBO:0000252
is: Q9BV79
constant: false
initial amount: NaN

metaM q10h2 m
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
is: HMDB13111
initial amount: NaN
name: Ubiquinol-10
constant: false

metaR r2126
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a503b706_d92b_4312_807d_56575b9e29f1
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR NH4tn
kinetic law: MODEL1310110017#
is: SBO:0000185
name: ammonia nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_71851f6c_5cb0_4aff_805f_10ed392d410c
boundary condition: true
initial amount: NaN
has only substance units: false
name: SOD1
is: P00441
type: Species
constant: false
is encoded by: hsa:6647
initial concentration: NaN
is: SBO:0000252

metaM citr L m
constant: false
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16349
is: HMDB00904
has only substance units: false
boundary condition: false
name: L-citrulline

metaM dttp c
is: HMDB01342
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:37568

metaM CE5121 m
constant: false
is: CHEBI:57449
name: trans-3-decenoyl-CoA
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM pe hs e
name: phosphatidylethanolamine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
is: CHEBI:16038
type: Species

metaM hco3 c
type: Species
has only substance units: false
name: Bicarbonate
is: CHEBI:17544
is: C00288
is: HMDB00595
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
boundary condition: false

metaR r1597
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR r0591
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110017#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
kinetic law: MODEL1310110017#

metaR r2125
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
type: Species
initial concentration: 1.0
name: D-glyceraldehyde
is: SBO:0000247
is: CHEBI:17378
boundary condition: false
is: HMDB01051
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4bf8061d_f583_4f54_ba51_4ed54425642f
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:27306
initial amount: NaN
is: O60760
name: HPGDS
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM dttp e
name: dTTP(4-)
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:37568
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
is: SBO:0000247

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_033fbb02_a016_4337_909b_61de64ce7f14
is: B4DG68
is encoded by: hsa:4842
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: NOS1
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_04b3227b_c17a_45c2_85dd_53d173cddbda
name: SDR16C5
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: B3KT84
initial amount: NaN
boundary condition: true
is encoded by: hsa:195814
is: SBO:0000252

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction

metaM triodthy c
is: HMDB00265
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
is: CHEBI:18258
constant: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine

metaM C05279 m
is: HMDB11123
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
is: CHEBI:28387
initial amount: NaN

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_ce8b5535_5d26_4552_806f_ae847b490ca5
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: _R33828_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:R33828

metaR r1598
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
reversible: true

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9f00da85_b22b_4a43_9432_37c86bf8f13d
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: LHPP
type: Species
constant: false
boundary condition: true
is encoded by: hsa:64077
has only substance units: false
is: Q9H008

metaR BDHm
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
is: SBO:0000176
type: Reaction
fast: false

metaR PCHOL HStg
reactant: MODEL1310110017#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: phosphatidylcholine scramblase
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_d63feaff_9b9b_4742_9257_5f3d0426ece9
constant: false
type: Species
is encoded by: hsa:122970
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q8N9L9
name: ACOT4

metaR UDPACGALtl
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
name: udpacgal intracellular transport
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_ba9c93d9_6244_445e_a14b_0c6634d67a21
boundary condition: true
constant: false
has only substance units: false
name: SLC25A1
is: D9HTE9
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6576
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_ceb10667_45ca_4937_9812_46185be858ce
is encoded by: hsa:25902
initial amount: NaN
name: MTHFD1L
is: B2RD24
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR r0818
reversible: false
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#

metaR GNDer
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110017#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM progly e
has only substance units: false
type: Species
is: HMDB11178
boundary condition: false
name: L-Prolinylglycine
notes: FORMULA: C7H12N2O3 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r0512
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true

metaR r1381
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_58086c9a_b797_4f8a_b227_50f0df39877c
name: RDH5
is: Q92781
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5959

metaM hco3 e
boundary condition: false
type: Species
is: HMDB00595
name: Bicarbonate
is: CHEBI:17544
is: C00288
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM nadp c
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58349
is: C00006
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110017#_bd488337_38a0_4549_80a2_510089a76268
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6241
initial amount: NaN
initial concentration: NaN
type: Species
name: RRM2
is: SBO:0000252
is: P31350

metaM lnlc r
is: HMDB00673
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30245
type: Species
boundary condition: false
name: linoleate
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial amount: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r2123
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR PNTOte
reactant: MODEL1310110017#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110017#
fast: false
type: Reaction
kinetic law: MODEL1310110017#
name: Transport of (R)-Pantothenate
is: SBO:0000185

metaR r1596
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_51bec02e_a1ed_4162_8811_eb5b29172aa9
is: P49902
name: NT5C2
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:22978
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR r0594
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176

metaM nadh c
constant: false
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: CHEBI:57945
is: C00004
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: HMDB01487
has only substance units: false
initial amount: NaN

metaM pa hs m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidate(2-)
is: CHEBI:57739
type: Species
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e6a6bab7_2a6a_41c2_84f0_453125f6aba0
is encoded by: hsa:3945
is: P07195
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: LDHB
boundary condition: true
constant: false
is: SBO:0000252

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_8a167cb4_6b73_48ee_8d9c_9a798232578c
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q5SYN6
name: SLC22A3
type: Species
is encoded by: hsa:6581
boundary condition: true
constant: false
is: SBO:0000252

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#

metaM 7dhchsterol c
constant: false
is: CHEBI:17759
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaM dump m
boundary condition: false
is: HMDB01409
constant: false
name: dUMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:246422

metaR PROSTGE1t
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaR r1668
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport

metaR NDP8
product: MODEL1310110017#
reversible: false
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
kinetic law: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000176

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_447b4335_5bdc_4f68_b957_dd2bcb2203dc
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:50700
type: Species
constant: false
initial concentration: NaN
is: Q9NYR8
name: RDH8

metaR ATPtm
is: SBO:0000185
reversible: false
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110017#
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110017#
fast: false

metaM ala D e
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15570
is: HMDB01310
name: D-alanine
initial amount: NaN

metaR 4HPRO LTte
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline
is: SBO:0000185
is described by: ECO:0000134
fast: false
type: Reaction
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true

metaR RE1836X
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
name: RE1836
type: Reaction
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
reversible: true

metaR ICDHxm
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.1.1.41
fast: false
name: Isocitrate dehydrogenase (NAD+)
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#

metaM HC02180 e
boundary condition: false
is: CHEBI:28728
type: Species
name: thromboxane-b2
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM ocdcea c
type: Species
is: CHEBI:0
initial concentration: 1.0
boundary condition: false
is: C00712
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
name: octadecenoate (n-C18:1)

metaR RE1796R
modifier: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796

metaR r2201
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_267ec1e8_3503_411d_b918_51926a79744a
constant: false
name: LDHAL6B
is: Q9BYZ2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:92483

metaM 4abut m
boundary condition: false
is: HMDB00112
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: CHEBI:16865
initial concentration: 1.0
name: 4-Aminobutanoate
constant: false
is: C00334
initial amount: NaN
is: SBO:0000247
type: Species

metaR r1669
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR SUCD1m
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
modifier: MODEL1310110017#
name: succinate dehydrogenase
reactant: MODEL1310110017#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000134
product: MODEL1310110017#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_91abcbfc_6fe6_464f_bda5_e066fa33fd4d
initial concentration: NaN
is: E9PB82
has only substance units: false
is encoded by: hsa:3295
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: HSD17B4

metaM prostgi2 e
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57403
is: HMDB01335
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaM gal e
initial amount: NaN
is: HMDB00143
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:0
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
constant: false
name: D-Galactose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_bfc329c7_567a_45cd_b5ff_6d158a82d7db
has only substance units: false
is: P23786
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1376
initial concentration: NaN
name: CPT2
initial amount: NaN

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110017#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_fb3efbb0_5212_4c4b_886b_53bd313f92ed
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:50
is: SBO:0000252
is: Q99798
initial amount: NaN
name: ACO2

http://identifiers.org/biomodels.db/MODEL1310110017#_7641b827_7aa8_49ab_928f_83c8ac37b9c1
is encoded by: hsa:160851
initial amount: NaN
name: DGKH
is: Q86XP1
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM so4 m
initial amount: NaN
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: SBO:0000247
is: HMDB01448
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110017#_8227a1cf_7495_4432_aaa3_6b83c637740c
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AL050025
name: _AL050025_1_c
boundary condition: true
is: SBO:0000252

metaR CHOLATEt
is: SBO:0000185
modifier: MODEL1310110017#
type: Reaction
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110017#
is described by: ECO:0000269
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110017#_d908408d_3591_40cc_9059_7b327155d8ba
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM HC02180 c
constant: false
boundary condition: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR G5SADs
reversible: false
is: SBO:0000176
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:Needed in L-proline biosynthesis
fast: false
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR RE1807C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
name: RE1807
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#

metaR r0145
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reversible: true
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.3.1
product: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is: SBO:0000176

metaM gal c
is: C00124
initial concentration: 1.0
is: HMDB00143
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:0
name: D-Galactose
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_da4cd41a_778e_4e07_afc8_f83a2d2876f7
has only substance units: false
is encoded by: hsa:55312
is: B2RDZ2
boundary condition: true
is: SBO:0000252
constant: false
name: RFK
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_aabc1de9_0a05_42ed_a217_a724c2880ffa
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: LGSN
is: SBO:0000252
is: Q5TDP6
is encoded by: hsa:51557

metaM met L e
has only substance units: false
is: HMDB00696
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16643
initial concentration: 1.0
is: SBO:0000247
name: L-methionine

metaM so4 l
name: sulfate
is: CHEBI:16189
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
is: HMDB01448
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0885
reactant: MODEL1310110017#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
modifier: MODEL1310110017#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaM taur e
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
type: Species
name: Taurine
boundary condition: false
initial amount: NaN
is: C00245
is: HMDB00251
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5c1570c9_d43d_4004_a7f0_8da02358fa33
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:206
has only substance units: false
boundary condition: true
name: _206_1_c
type: Species
constant: false

metaR L LACt4r
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
name: L-lactate reversible transport via sodium symport
fast: false
is described by: ECO:0000000

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM prostgi2 c
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57403
constant: false
initial amount: NaN
name: prostaglandin I2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
is: SBO:0000247

metaM dcholcoa r
has only substance units: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_5a007f3c_56f1_493d_942a_8fb36f2f64be
type: Species
constant: false
is encoded by: hsa:55568
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GALNT10
boundary condition: true
has only substance units: false

metaR r0208
modifier: MODEL1310110017#
type: Reaction
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110017#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_51202b68_8f99_4132_9aee_2dfac128b2b4
is: SBO:0000252
name: ADH5
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q6IRT1
is encoded by: hsa:128
initial amount: NaN
constant: false

W3 CDTF: Fri Aug 31 05:06:21 BST 2012

metaR FORt2m
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
product: MODEL1310110017#
name: formate mitochondrial transport
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#

metaR r2317
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_16c6addf_9d9c_4bda_9d7d_2054cdeb5587
constant: false
initial amount: NaN
initial concentration: NaN
name: GCSH
has only substance units: false
boundary condition: true
is: P23434
is encoded by: hsa:2653
type: Species
is: SBO:0000252

metaM gthrd m
has only substance units: false
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: glutathionate(1-)
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: HMDB00125

metaR RE1796M
is: SBO:0000176
reversible: true
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
name: RE1796
modifier: MODEL1310110017#
is described by: ECO:0000000

metaM rib D e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: D-ribose
type: Species
constant: false
is: HMDB00283
is: SBO:0000247
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaM pro L m
name: L-proline
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB00162
is: CHEBI:17203
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN

metaR r1664
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110017#
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false
reactant: MODEL1310110017#

metaM itp c
boundary condition: false
constant: false
has only substance units: false
name: ITP(3-)
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00189
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_0c9d671c_5f3d_4627_9d28_9b0f454af760
constant: false
type: Species
has only substance units: false
boundary condition: true
name: _AI971036_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
initial concentration: NaN

metaR r2318
reversible: true
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000

metaM CE5236 c
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:28002
is: HMDB03952
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaM dutp c
initial concentration: 1.0
is: C00460
is: HMDB01191
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
name: dUTP
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17625

metaM taur c
initial amount: NaN
is: CHEBI:3544
is: C00245
boundary condition: false
constant: false
name: Taurine
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251

metaR GLNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
name: L-glutamine transport via electroneutral transporter
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction

metaM xol7aone m
boundary condition: false
is: HMDB01993
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c40c7eba_9b44_45c7_b01b_6ed30adb2008
constant: false
is: Q96C36
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29920
type: Species
initial concentration: NaN
initial amount: NaN
name: PYCR2
has only substance units: false

metaR r1665
fast: false
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM 4abutn m
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: SBO:0000247
is: HMDB01080
boundary condition: false
has only substance units: false
name: 4-ammoniobutanal
constant: false
is: CHEBI:58264
initial concentration: 1.0
type: Species

metaM Rtotal2 e
initial concentration: 1.0
is: CHEBI:3554
type: Species
is: C00255
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
name: R total 2 position
is: HMDB00244
constant: false

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false

metaR RETH2e
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
name: retinyl ester hydrolase (11-cis), extracellular
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM ala D c
is: CHEBI:15570
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_9e75d3e9_ee55_490c_adfe_9e1fd282d84b
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI480132
name: _AI480132_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r2319
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_60c2f80b_2df4_42e9_b55f_7584733716fb
is encoded by: hsa:3550
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: IK
has only substance units: false
is: Q13123
initial concentration: NaN
initial amount: NaN

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:

metaR FRDPtr
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110017#
name: lipid, flip-flop intracellular transport
product: MODEL1310110017#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f791580d_e747_485e_a972_e1cf49d8b81e
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1633
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P27707
name: DCK

metaR r1666
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00707

metaM itp e
boundary condition: false
has only substance units: false
is: CHEBI:57614
type: Species
name: ITP(3-)
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR CYOOm3
reversible: false
name: cytochrome c oxidase, mitochondrial Complex IV
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000134
modifier: MODEL1310110017#

metaR DNDPt13m
product: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via ATP antiport

metaM 13dpg c
initial concentration: 1.0
is: CHEBI:57604
is: C00236
boundary condition: false
name: 3-Phospho-D-glyceroyl phosphate
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
is: SBO:0000247
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaR CHOLt4
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110017#
fast: false
name: choline, sodium cotransport
reactant: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_ce73ad51_cc02_4703_8cb8_5dcc721efe48
boundary condition: true
is encoded by: hsa:3295
constant: false
is: E9PB82
name: HSD17B4
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM itacon m
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17240
initial amount: NaN
is: HMDB02092
boundary condition: false
name: itaconate(2-)
type: Species
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

metaM CE5788 e
is: SBO:0000247
is: CHEBI:27485
has only substance units: false
initial concentration: 1.0
constant: false
name: kinetensin 1-7
initial amount: NaN
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: HMDB02710
type: Species
boundary condition: false

metaM ocdcea e
is: C00712
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00207
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
is: CHEBI:0
name: octadecenoate (n-C18:1)

metaM HC01496 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:28095
initial amount: NaN
name: 2-Amino-3-oxoadipate
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false

metaR r0881
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
name: Active transport
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#

metaM HC02208 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
constant: false
has only substance units: false
is: CHEBI:27696
initial amount: NaN

metaR r1667
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
modifier: MODEL1310110017#
reactant: MODEL1310110017#

metaR r0149
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_35eeb18f_0c02_483c_9589_ce11baaed277
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4716
has only substance units: false
boundary condition: true
name: NDUFB10
is: A8K761
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_df90ab2f_abfa_4b8d_89ae_a0091b94f09f
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56623
initial amount: NaN
constant: false
name: INPP5E
type: Species
has only substance units: false
is: Q9NRR6
initial concentration: NaN

metaM dhcholestancoa x
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB02159
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: CHEBI:15494
has only substance units: false

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r1660
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_306bf24b_1d6e_436b_a6be_2ae4494c5d9d
is: B7Z1R0
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57282
name: SLC4A10
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR CITL
name: Citrate lyase
kinetic law: MODEL1310110017#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reactant: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#

metaR r0084
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110017#
is described by: ECO:0000000
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR r2079
fast: false
reversible: true
modifier: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2313
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ad1abc54_3820_403a_8448_4f8781c71849
is encoded by: hsa:349565
has only substance units: false
type: Species
is: Q96T66
initial amount: NaN
constant: false
boundary condition: true
name: NMNAT3
is: SBO:0000252
initial concentration: NaN

metaR NACHEXA21ly
type: Reaction
reversible: false
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR XOL7AONEtr
is: SBO:0000185
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_c9370978_aa1e_45e8_82a9_479b5e99c1ba
is: P20132
type: Species
has only substance units: false
initial concentration: NaN
name: SDS
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:10993

http://identifiers.org/biomodels.db/MODEL1310110017#_3b09db05_411c_4e40_a74e_5b3b496e3b26
is encoded by: hsa:NM 001929
initial concentration: NaN
constant: false
is: SBO:0000252
name: _NM_001929_1_c
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17295
constant: false
name: L-phenylalanine
is: HMDB00159
initial concentration: 1.0
boundary condition: false
type: Species

metaM CE1925 e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
is: CHEBI:15748
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00127
name: 3'-carboxy-alpha-chromanol
initial amount: NaN

metaM prostge1 c
has only substance units: false
type: Species
constant: false
is: HMDB01442
initial concentration: 1.0
initial amount: NaN
name: prostaglandin E1(1-)
boundary condition: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110017#
reversible: true
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110017#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185

metaM HC02208 e
name: prostaglandin-d1
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: CHEBI:27696
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM ala L c
is: HMDB00161
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
name: L-alanine
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r1661
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_9f47f0f3_9104_4d62_ba66_299cee9bc831
name: _2544_1_c
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2544

metaM retinol c
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
initial concentration: 1.0
constant: false
initial amount: NaN
name: retinol
type: Species
has only substance units: false
is: CHEBI:50211
is: SBO:0000247

metaR r0085
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is version of: http://identifiers.org/ec-code/1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110017#_31541507_4bc9_4dfa_b176_b6ea92576e73
is encoded by: hsa:8525
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DGKZ
has only substance units: false
is: SBO:0000252
constant: false
is: B7Z2M9
type: Species

metaR RE1533M
is: SBO:0000176
name: RE1533
fast: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR HISSNAT5tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR ALDD2y
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: false
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR r1948
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110017#

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_da9635c4_ff3c_4dcd_8853_c1091e4305ae
name: _AW299740_1_m
initial concentration: NaN
is encoded by: hsa:AW299740
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR r2314
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR ALAtN1
fast: false
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
is: SBO:0000185
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#

W3 CDTF: Fri Aug 31 05:06:22 BST 2012

metaR r1662
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false

metaM gthox e
initial amount: NaN
has only substance units: false
is: CHEBI:58297
is: HMDB03337
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

metaM 11 cis retfa e
has only substance units: false
initial amount: NaN
is: CHEBI:16236
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid 11-cis-retinol
is: HMDB00108

http://identifiers.org/biomodels.db/MODEL1310110017#_8dff2e53_b4a0_4755_a1b2_9434a128b802
constant: false
initial amount: NaN
boundary condition: true
name: ABP1
type: Species
has only substance units: false
is encoded by: hsa:26
is: P19801
is: SBO:0000252
initial concentration: NaN

metaR r0082
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.2
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is described by: ECO:0000000

metaR r0630
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110017#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false

metaM 4ppcys m
is: HMDB01117
is: SBO:0000247
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species
has only substance units: false
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: CHEBI:59458
initial concentration: 1.0

metaM xol7aone r
is: SBO:0000247
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
is: CHEBI:17899
boundary condition: false
is: HMDB01993

http://identifiers.org/biomodels.db/MODEL1310110017#_2eaf9dcc_a981_42e5_9e7a_da11c3fbe9f0
name: AMY1B
initial concentration: NaN
is encoded by: hsa:277
is: SBO:0000252
is: P04745
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaM HC02217 c
constant: false
is: SBO:0000247
is: CHEBI:27647
name: prostaglandin-g2
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f66eceff_c439_4990_bade_f742a9a7f916
is encoded by: hsa:56954
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NIT2
is: Q9NQR4
has only substance units: false

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110017#
name: valine transaminase
reversible: true

metaR ALDD2x
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110017#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110017#
reversible: false
type: Reaction
reactant: MODEL1310110017#

metaR r2315
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5480154c_d778_4b0f_9368_d548c5d1c6cc
name: SLC24A4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:123041
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM gthrd c
name: Reduced glutathione
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00125
initial concentration: 1.0
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
is: CHEBI:57925
is: C00051

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

W3 CDTF: Fri Aug 31 05:06:22 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110017#_64022808_f2d0_4b94_9d47_672a152c5f76
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: GALNT11
is encoded by: hsa:63917
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B3KWF4

metaM retinol e
is: HMDB00305
type: Species
is: CHEBI:50211
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
boundary condition: false
name: retinol
constant: false

metaR r0083
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110017#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
is: SBO:0000247
is: CHEBI:57397
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01442
constant: false

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM gdp c
is: HMDB01201
constant: false
name: GDP
is: C00035
is: CHEBI:58189
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR KYNATESYN
type: Reaction
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
reversible: false
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_d512ca48_75ad_412d_92ce_553ac1cb622c
is: SBO:0000252
name: GPT2
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84706
boundary condition: true
is: Q8TD30

W3 CDTF: Fri Aug 31 05:06:21 BST 2012

metaR ATPtx
name: ATP transporter, peroxisomal
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f96afd3b_50e3_4c50_85ec_9810689372a2
constant: false
type: Species
initial amount: NaN
name: ALDH1A3
is: SBO:0000252
is: P47895
is encoded by: hsa:220
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM pro L e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
is: SBO:0000247
name: L-proline
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00162
is: CHEBI:17203
boundary condition: false

metaR r0497
is described by: ECO:0000000
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110017#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_cc6ead33_fe49_44f1_8ec0_089d83e68a28
is encoded by: hsa:56901
is: Q9NRX3
is: SBO:0000252
constant: false
name: NDUFA4L2
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR CYSGLUexR
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
name: L-cysteine/L-glutamine reversible exchanger
product: MODEL1310110017#

metaM gthox c
has only substance units: false
is: HMDB03337
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58297
name: Oxidized glutathione
constant: false
is: C00127
type: Species

metaM dopa c
has only substance units: false
is: HMDB00073
type: Species
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
initial amount: NaN
is: CHEBI:59905
constant: false
boundary condition: false
is: SBO:0000247

metaR NADtpu
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
name: NAD transporter, peroxisome

metaM dcholcoa c
boundary condition: false
type: Species
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
is: HMDB06292
constant: false
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110017#_1b8dd6e5_3867_4fb3_a91b_4587b218bd1d
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:341947
has only substance units: false
is: Q7Z4L0
type: Species
initial amount: NaN
initial concentration: NaN
name: COX8C

metaM CE1944 c
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
type: Species
initial amount: NaN
name: 1-pyrrolinium
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:36781

metaM gthrd e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
is: HMDB00125
constant: false
is: CHEBI:57925
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_6c4888f9_63bc_4f9f_bb7e_8c7468d9fae0
has only substance units: false
type: Species
is encoded by: hsa:275
name: AMT
is: P48728
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000006
type: Reaction

metaR r0774
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110017#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR ASCBt
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
is described by: ECO:0000000
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000185

metaM ocdca e
is: C01530
is: CHEBI:25629
name: octadecanoate (n-C18:0)
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_65251169_ea1c_4c14_a7f6_0da9672b033b
is encoded by: hsa:10400
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: PEMT
boundary condition: true
is: Q9UBM1
constant: false

metaM met L c
constant: false
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16643
boundary condition: false
name: L-methionine
has only substance units: false

metaM adrnl c
boundary condition: false
name: Adrenaline
type: Species
is: CHEBI:33568
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
initial concentration: 1.0
is: HMDB00068

metaM CE0849 m
type: Species
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: C01936
name: cis,cis-palmito-7,10-dienoyl-CoA
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0

metaR r1512
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110017#
name: Utilized transport
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000

metaR CYSO
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.20
type: Reaction
name: cysteine oxidase
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e4c201dd_e435_4ca2_82ea_1e39655f355f
name: CYP27A1
is: SBO:0000252
type: Species
is encoded by: hsa:1593
initial amount: NaN
is: Q02318
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_d543b924_9af4_4643_b25f_ff55ade163b3
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4514
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: COX3
is: P00414

http://identifiers.org/biomodels.db/MODEL1310110017#_7461c6d4_b8ef_48d8_bed0_e8f0e22ba243
type: Species
is encoded by: hsa:D29675
name: _D29675_1_e
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r2310
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:58264
has only substance units: false
name: 4-ammoniobutanal
initial concentration: 1.0
is: HMDB01080
is: SBO:0000247

metaM no c
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16480
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: HMDB03378
is: C00533
constant: false
name: Nitric oxide
is: SBO:0000247

metaM zymstnl r
is: CHEBI:16608
initial amount: NaN
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_07c0b6d8_3ad6_45c3_a269_3ae588517369
is: SBO:0000252
initial amount: NaN
type: Species
name: _T83654_1_e
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:T83654
constant: false

metaM dopa e
is: CHEBI:59905
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: dopaminium(1+)
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR D 3AIBt
name: D-3-amino-isobutyrate transport
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185

metaM ura e
has only substance units: false
initial concentration: 1.0
name: uracil
type: Species
is: CHEBI:17568
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

metaM pro L c
is: SBO:0000247
is: CHEBI:17203
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00162
constant: false
name: L-proline
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_39caf10c_20a0_4037_9977_355f98208a73
type: Species
name: _AI539321_1_c
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI539321
boundary condition: true

metaR r2311
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110017#
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
name: difussion of glycerol accross the brush border membrane

metaM adrnl e
boundary condition: false
type: Species
initial amount: NaN
name: Adrenaline
is: CHEBI:33568
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00068
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788

http://identifiers.org/biomodels.db/MODEL1310110017#_75619759_8da9_4232_a3af_25ab2e702a78
initial amount: NaN
boundary condition: true
is: C9JC79
is: SBO:0000252
is encoded by: hsa:6342
initial concentration: NaN
name: SCP2
constant: false
type: Species
has only substance units: false

metaR CYTDK1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.48
name: ATPcytidine 5-phosphotransferase
type: Reaction
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110017#_3d5f285d_1a71_46e9_b365_6a7283139b06
has only substance units: false
is: SBO:0000252
type: Species
name: IDH3B
constant: false
is encoded by: hsa:3420
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM xol25oh r
is: CHEBI:42977
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: 25-hydroxycholesterol
has only substance units: false
is: HMDB06247

metaM ala L e
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
name: L-alanine
is: HMDB00161
is: CHEBI:16977

metaR r0494
fast: false
is: SBO:0000176
reactant: MODEL1310110017#
is described by: ECO:0000000
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
type: Reaction

metaM 4abutn c
is: SBO:0000247
boundary condition: false
is: C00555
constant: false
type: Species
initial amount: NaN
is: CHEBI:58264
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-Aminobutanal
initial concentration: 1.0
is: HMDB01080

metaM no e
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
initial concentration: 1.0
type: Species
is: CHEBI:16480
has only substance units: false
is: HMDB03378
initial amount: NaN
is: C00533

metaR ABTti
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
fast: false
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR r2312
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#

metaM q10 m
is: HMDB01072
initial amount: NaN
name: ubiquinone-10
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
is: CHEBI:46245
constant: false
initial concentration: 1.0

metaR r2532
reversible: true
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110017#_2c46ec79_3cd1_44a8_ab1b_5879a736d60e
is encoded by: hsa:6567
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: SLC16A2
is: P36021

metaM ac c
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
boundary condition: false
is: SBO:0000247
name: acetate
constant: false
is: HMDB00042
initial concentration: 1.0
type: Species
has only substance units: false

metaM gdp m
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58189
is: HMDB01201
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: C00035
initial concentration: 1.0

metaM q10 c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB01072
name: ubiquinone-10
has only substance units: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
boundary condition: false

metaR r1454
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_dd661f5d_ad96_4011_9365_6bd99570c2c3
initial concentration: NaN
is: P06865
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3073
boundary condition: true
has only substance units: false
constant: false
name: HEXA

http://identifiers.org/biomodels.db/MODEL1310110017#_b6b8e6de_4aa7_4c6a_99f8_e7ac7e9fb5a2
is: SBO:0000252
is encoded by: hsa:AI222095
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: _AI222095_1_m
initial concentration: NaN

metaR SUCCtp
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: succinate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

metaR LEUt5m
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
name: leucine mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
type: Reaction

metaR DHCR72r
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
name: 7-dehydrocholesterol reductase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_81cb23ce_6047_417d_b3f1_7f6ee9501e77
is: Q15125
is: SBO:0000252
is encoded by: hsa:10682
type: Species
boundary condition: true
initial concentration: NaN
name: EBP
constant: false
has only substance units: false
initial amount: NaN

metaR GLNtN1
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
reversible: true
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_39767866_d7f3_4022_9ea0_f6e7762122da
name: PECR
is: Q9BY49
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:55825
initial amount: NaN
boundary condition: true
has only substance units: false

metaR DNDPt24m
fast: false
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
name: dTDP transport via dADP antiport
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaM ala B c
constant: false
is: CHEBI:16958
name: beta-alanine
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
type: Species
is: SBO:0000247

metaM CE5236 n
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB03952
is: CHEBI:28002

metaM ura c
boundary condition: false
initial concentration: 1.0
is: HMDB00300
type: Species
initial amount: NaN
constant: false
name: Uracil
is: SBO:0000247
is: C00106
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568

metaM ocdcea r
constant: false
is: SBO:0000247
boundary condition: false
is: C00712
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
initial amount: NaN
type: Species
name: octadecenoate (n-C18:1)
has only substance units: false

metaM imp c
is: C00130
boundary condition: false
has only substance units: false
is: CHEBI:58053
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
is: HMDB00175
name: IMP
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_b3b2aca0_5eb9_413b_9eac_43df7e51afb0
is: Q5JPA4
has only substance units: false
is encoded by: hsa:53919
boundary condition: true
constant: false
name: SLCO1C1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM 3hmbcoa m
is: HMDB01356
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
initial concentration: 1.0

metaR r0410
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000176
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000
product: MODEL1310110017#

metaM ile L e
type: Species
is: CHEBI:17191
has only substance units: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
name: L-isoleucine
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r1167
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
is described by: ECO:0000000
name: EC:2.3.1.26
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#

metaR FALDH
is described by: ECO:0000269
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
fast: false

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2320
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110017#
type: Reaction
fast: false
kinetic law: MODEL1310110017#

metaR ACETONEt2
name: acetone transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110017#

metaM ha e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
type: Species
is: CHEBI:16336
constant: false
boundary condition: false
has only substance units: false
name: hyaluronan

http://identifiers.org/biomodels.db/MODEL1310110017#_e2829675_ce40_4245_957a_5fcaebb3965c
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q9BYZ2
has only substance units: false
is encoded by: hsa:92483
initial concentration: NaN
name: LDHAL6B
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_2284df1f_b4a5_49b7_befe_101733dd52df
boundary condition: true
type: Species
constant: false
name: ACOX2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q99424
has only substance units: false
is encoded by: hsa:8309

metaM ac e
has only substance units: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00042
type: Species
name: acetate
initial concentration: 1.0
initial amount: NaN

metaR PPAn
type: Reaction
product: MODEL1310110017#
fast: false
reversible: false
name: inorganic diphosphatase, nuclear
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_d6fe7e34_3dc4_49a0_97c7_cf912d68e3cd
type: Species
is: SBO:0000252
constant: false
is: Q5QPH3
initial concentration: NaN
name: ACSS2
initial amount: NaN
is encoded by: hsa:55902
has only substance units: false
boundary condition: true

metaM HC01118 r
type: Species
boundary condition: false
constant: false
has only substance units: false
name: presqualene diphosphate(3-)
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57310
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_6790bf98_ed70_4c55_87ed_c62235d1fab1
type: Species
is: SBO:0000252
name: _BG035985_1_c
has only substance units: false
is encoded by: hsa:BG035985
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaM ocdca c
initial amount: NaN
boundary condition: false
is: HMDB00827
is: CHEBI:25629
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: stearate
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530

metaM ribflv c
is: HMDB00244
is: C00255
constant: false
is: CHEBI:3554
is: SBO:0000247
name: Riboflavin
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0

metaR r0779
product: MODEL1310110017#
modifier: MODEL1310110017#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_77908e8c_5273_4055_93d4_9448b7ccdcef
is encoded by: hsa:5476
name: CTSA
has only substance units: false
is: P10619
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0638
kinetic law: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110017#
type: Reaction
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_e16bf13f_7471_4552_9fa7_d1e8cb4175f2
has only substance units: false
type: Species
is encoded by: hsa:3291
boundary condition: true
is: P80365
initial concentration: NaN
initial amount: NaN
name: HSD11B2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_0a6be635_3741_4cfb_8676_d6452b5aa775
constant: false
boundary condition: true
name: ENPP3
is encoded by: hsa:5169
initial amount: NaN
is: Q308M7
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM ala B e
constant: false
is: CHEBI:16958
name: beta-alanine
boundary condition: false
initial amount: NaN
is: HMDB00056
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR DURIt
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_c2733bfe_6714_45a9_8cdb_5564fb177e54
name: _AV717590_1_c
is encoded by: hsa:AV717590
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR RE3556C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
name: RE3556
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_fbe30999_2ae8_45f7_8a1a_75eae1cc6ed4
boundary condition: true
name: _AF080579_1_c
is encoded by: hsa:AF080579
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR FOLt2le
fast: false
product: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: folate transport via anion exchange
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_5d1036a8_91fe_4ab8_bed6_939a61aaad1b
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O95168
name: NDUFB4
is encoded by: hsa:4710
is: SBO:0000252
initial amount: NaN

metaM ile L c
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
name: L-isoleucine
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110017#_964b69c7_b60f_4fa5_907a_e473e3e047ef
name: _AV727634_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AV727634
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a32e2d88_1021_43bc_80cd_98f8f051130e
boundary condition: true
is encoded by: hsa:LOC374569
constant: false
type: Species
has only substance units: false
name: _LOC374569_1_e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM s7p c
has only substance units: false
type: Species
is: SBO:0000247
name: Sedoheptulose 7-phosphate
is: CHEBI:57483
boundary condition: false
is: HMDB01068
constant: false
initial amount: NaN
is: C05382
initial concentration: 1.0
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

metaR r1450
type: Reaction
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110017#
name: EC:1.3.3.6
is described by: ECO:0000000

metaR BUTt2r
fast: false
reversible: true
modifier: MODEL1310110017#
product: MODEL1310110017#
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110017#_d750b397_c823_4b55_a482_9338d95b29b4
is: SBO:0000252
is encoded by: hsa:4357
is: P25325
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: MPST

http://identifiers.org/biomodels.db/MODEL1310110017#_7bd9784d_808c_40a2_ad36_80784c384611
is: SBO:0000252
name: GPX3
is: P22352
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2878
type: Species
initial concentration: NaN
constant: false

metaM 34dhpha c
name: (3,4-dihydroxyphenyl)acetate
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB01336
is: CHEBI:17612
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR SPH1Pte
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
name: sph1p transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110017#
reversible: true

metaR FRDPtc
is described by: ECO:0000000
type: Reaction
name: lipid, flip-flop intracellular transport
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110017#
is: SBO:0000185

metaM cholp c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:295975
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

metaM ribflv e
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:3554
type: Species
is: SBO:0000247
is: C00255
initial concentration: 1.0
name: Riboflavin
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110017#_6eaeb2be_3e9a_4b7d_85a1_40debe619f9d
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q99714
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3028
name: HSD17B10

http://identifiers.org/biomodels.db/MODEL1310110017#_679e7492_06c9_4f9b_aa51_07fbcd935a38
is encoded by: hsa:10005
has only substance units: false
is: O14734
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: ACOT8
constant: false

metaR RBTt
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
name: ribitol transport via passive diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110017#

metaM ser L c
has only substance units: false
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
name: L-serine
initial amount: NaN
is: CHEBI:17115
boundary condition: false
is: SBO:0000247
is: HMDB00187
initial concentration: 1.0

metaR RE1521M
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: RE1521
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110017#

metaR r1451
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: EC:1.3.3.6
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

metaR CYTK8n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dATP),nuclear
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is: SBO:0000176
fast: false
modifier: MODEL1310110017#

metaM creat e
boundary condition: false
name: creatine
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00064
constant: false
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919

metaR GALASE17ly
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR PPAm
product: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269
name: inorganic diphosphatase
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
fast: false
reversible: false

metaM q10 e
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:46245
name: ubiquinone-10
has only substance units: false
type: Species
boundary condition: false

metaR r1050
name: Vesicular transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaM ksii core2 deg2 l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
is: CHEBI:12936
type: Species
boundary condition: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial amount: NaN

metaR GCC2cm
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110017#
fast: false
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR LEUKTRF4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110017#
name: leukotriene F4 transport
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_e3a6029d_af28_41f4_96ea_18b4c92048df
initial amount: NaN
is encoded by: hsa:1503
constant: false
is: P17812
boundary condition: true
has only substance units: false
name: CTPS1
is: SBO:0000252
type: Species
initial concentration: NaN

metaR DM Ser Thr ly
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_a3fc7370_f8d1_41f7_9931_d613df610329
name: PLD1
is: Q59EA4
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5337
boundary condition: true

metaM 4abut c
type: Species
boundary condition: false
is: CHEBI:3628
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00334
name: 4-Aminobutanoate
constant: false
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110017#_1fee7a51_2435_43a4_b37b_229ae4e69cc7
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: P46926
initial concentration: NaN
name: GNPDA1
is encoded by: hsa:10007
has only substance units: false

metaR r1051
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
name: Vesicular transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_0641e79a_5f34_4c4d_96c7_995fdf6cd6b6
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: BDH1
is: Q02338
is encoded by: hsa:622

metaR METATB0tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Methionine into the intestinal cells by ATB0 transporter
type: Reaction

metaM ser L e
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
name: L-serine
is: SBO:0000247
is: HMDB00187
boundary condition: false

metaR r0634
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110017#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_d3c79b5d_3829_41fe_9045_b785534e95cf
is encoded by: hsa:28231
is: Q96BD0
has only substance units: false
name: SLCO4A1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaM phe L e
is: HMDB00159
name: L-phenylalanine
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17295
boundary condition: false

metaR r1453
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is: SBO:0000176
reversible: true
fast: false
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_739a7f1d_087a_4402_b916_a030da3e7a12
is encoded by: hsa:760
boundary condition: true
name: CA2
is: SBO:0000252
initial amount: NaN
is: P00918
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaM 4abut e
name: 4-Aminobutanoate
constant: false
type: Species
is: HMDB00112
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_94f45bde_19ef_4e68_a1c2_4e54607ade90
is encoded by: hsa:4697
constant: false
initial amount: NaN
initial concentration: NaN
is: O00483
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: NDUFA4

metaR ALASm
kinetic law: MODEL1310110017#
is described by: ECO:0000254
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.29
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reversible: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.37
product: MODEL1310110017#
name: 5-aminolevulinate synthase
reactant: MODEL1310110017#

metaM amp x
name: AMP
boundary condition: false
is: HMDB00045
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C00020

http://identifiers.org/biomodels.db/MODEL1310110017#_866fd175_8482_4986_9eeb_fba5079e00e2
constant: false
initial amount: NaN
boundary condition: true
name: GALNT13
has only substance units: false
type: Species
is: SBO:0000252
is: Q8IUC8
initial concentration: NaN
is encoded by: hsa:114805

metaR r1722
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110017#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_58a1550e_0d40_4a05_a0b8_07d8207d51db
constant: false
is encoded by: hsa:3420
is encoded by: hsa:3421
initial amount: NaN
has part: O43837
is: SBO:0000297
has only substance units: false
initial concentration: NaN
has part: P51553
name: IDH3A:IDH3B:IDH3G
boundary condition: true
type: Species

metaM cys L e
is: CHEBI:17561
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
type: Species
is: HMDB00574
boundary condition: false
constant: false
has only substance units: false
name: L-cysteine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_7a96d903_9f65_463f_b25d_351b9b2c06d8
initial concentration: NaN
is: P40926
has only substance units: false
name: MDH2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4191
type: Species
initial amount: NaN
constant: false

metaR NACHEXA22ly
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176

metaM ach c
is: HMDB00895
is: SBO:0000247
boundary condition: false
is: CHEBI:15355
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: acetylcholine

metaR GLYSNAT5tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_b0d95447_4e45_4b0a_bb4d_7f7617ba0580
is: Q99944
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: EGFL8
is encoded by: hsa:80864
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_02910f5c_a8e0_4d31_9111_d773e05be81a
is encoded by: hsa:1491
is: P32929
type: Species
has only substance units: false
constant: false
name: CTH
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM ksii core4 e
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II (core 4-linked)
boundary condition: false
type: Species
is: CHEBI:17268
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
constant: false
is: HMDB00211
has only substance units: false

metaR 3MOX4HOXPGALDOX NADP
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110017#
fast: false
reversible: true
is described by: ECO:0000304
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM Rtotal c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16189
type: Species
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
is: HMDB01448
initial amount: NaN

metaM ile L m
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
name: L-isoleucine
constant: false
initial concentration: 1.0
is: HMDB00172
type: Species
is: SBO:0000247
has only substance units: false

metaM cys L c
is: CHEBI:17561
constant: false
is: HMDB00574
boundary condition: false
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_63c97c3c_30fc_4988_815f_1c2ead043a12
is: Q8IZH9
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2643
constant: false
boundary condition: true
initial amount: NaN
name: GCH1
type: Species
has only substance units: false

metaR ITPtn
kinetic law: MODEL1310110017#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: ITP nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM gal l
name: D-galactose
has only substance units: false
is: HMDB00143
type: Species
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_f452c7d6_41dd_44fd_af1f_4c5c26a9a19a
initial amount: NaN
name: _AI090874_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:AI090874

http://identifiers.org/biomodels.db/MODEL1310110017#_bfffd630_44d2_4b51_bbc2_626e8ee7ad7c
initial amount: NaN
name: ACADL
boundary condition: true
initial concentration: NaN
is encoded by: hsa:33
type: Species
is: P28330
is: SBO:0000252
has only substance units: false
constant: false

metaR 3AIB Dtm
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
name: transport of 3aib_D into mitochondria
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:

metaR BHBtm
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction
reactant: MODEL1310110017#

metaR FADH2tx
name: FADH2 transporter, peroxisomal
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_0cd2e993_d6f2_43c7_bd80_8c986077efdd
is: SBO:0000252
type: Species
boundary condition: true
is: B3KVI7
constant: false
name: IVD
is encoded by: hsa:3712
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a36e2ff5_b946_46c4_8b73_52cacc6962f3
is: Q8TCD5
is: SBO:0000252
name: NT5C
is encoded by: hsa:30833
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM spmd c
name: Spermidine
is: SBO:0000247
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
initial concentration: 1.0
is: HMDB01257
has only substance units: false
is: CHEBI:57834
constant: false
boundary condition: false
is: C00315
initial amount: NaN

metaM idp n
is: HMDB03335
type: Species
is: CHEBI:58280
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
initial amount: NaN
name: IDP(3-)

metaR CYSGLTH
fast: false
reactant: MODEL1310110017#
name: Glutathione:cystine oxidoreductase
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_388379c7_7da2_4a6f_85cb_594ac5a3cb61
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4831
constant: false
name: NME2
is: P22392
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR MECOAS1m
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176

metaR ADK3m
name: adentylate kinase (GTP)
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10

metaR CYTK11n
name: cytidylate kinase (dCMP,dGTP),nuclear
is described by: ECO:0000269
fast: false
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_f1f8cbb5_ca4d_438e_8e74_4603307a618b
name: DGKZ
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8525
boundary condition: true
is: G3V0F6
is: SBO:0000252
initial concentration: NaN
type: Species

metaR ACHEe
is version of: http://identifiers.org/ec-code/3.1.1.7
reactant: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110017#
name: Acetylcholinesterase
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c78d2109_b610_4823_baf1_4f61be2c82e7
type: Species
boundary condition: true
name: TXNRD1
is: Q16881
is encoded by: hsa:7296
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_0dbc13b5_0997_4e83_ac78_6bbea50f532f
has only substance units: false
name: PKM2
is: P14618
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5315

metaM orot e
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:30839
is: HMDB00226
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: orotate

metaM lys L x
is: HMDB00182
name: L-lysinium(1+)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_be927c26_db3d_462a_a9ad_c320808d8a16
is: O14495
name: PPAP2B
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8613
has only substance units: false
is: SBO:0000252

metaM ac m
constant: false
is: HMDB00042
is: CHEBI:30089
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
boundary condition: false

metaM leuktrA4 c
is: HMDB01337
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57463
name: leukotriene A4(1-)
constant: false
has only substance units: false

metaR GALt4
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: galactose transport via sodium symport
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaR DM sTn antigen g
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM sTn antigen(g)
type: Reaction

metaR S23Tg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110017#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
kinetic law: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e5176492_0858_444f_9ffa_3a6940c93a2d
initial amount: NaN
name: SLC5A3
is encoded by: hsa:6526
constant: false
type: Species
initial concentration: NaN
is: P53794
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_5cb2abba_b1b8_4cec_af50_ca05fd42caa1
is: P00374
initial amount: NaN
has only substance units: false
is encoded by: hsa:1719
boundary condition: true
name: DHFR
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM k e
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
is: C00238
is: CHEBI:29103
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: potassium

metaM ach e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
is: CHEBI:15355
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00895

metaM k c
boundary condition: false
initial amount: NaN
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
has only substance units: false
constant: false
name: potassium
is: HMDB00586
initial concentration: 1.0
is: SBO:0000247
is: C00238

metaM rib D c
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
name: D-ribose
is: HMDB00283
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16988

metaR RE1518M
reactant: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM Rtotal e
initial concentration: 1.0
constant: false
is: CHEBI:3554
has only substance units: false
type: Species
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
boundary condition: false
is: HMDB00244
initial amount: NaN
is: SBO:0000247

metaM ha l
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
boundary condition: false
name: hyaluronan
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM creat c
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: creatine
constant: false
is: CHEBI:16919
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_e2c930fc_d855_491d_aeb4_d28d6e5686bf
is: E7EPA7
name: TKT
boundary condition: true
is encoded by: hsa:7086
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_43690143_9406_43dc_85e8_35bf4fcb1114
name: LDHC
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:3948

metaR r1723
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false

metaM xylt c
is: CHEBI:17151
is: HMDB02917
boundary condition: false
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: xylitol
has only substance units: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM pa hs g
type: Species
constant: false
is: CHEBI:57739
initial amount: NaN
is: SBO:0000247
name: phosphatidate(2-)
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
has only substance units: false

metaR P450SCC1m
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000134
name: cholesterol monooxygenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is: SBO:0000176
reversible: true
fast: false

metaM spmd e
constant: false
has only substance units: false
is: C00315
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Spermidine
type: Species
is: HMDB01257
is: CHEBI:57834

metaM so4 e
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: sulfate
is: HMDB01448
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
is: CHEBI:16189

metaR r2420
product: MODEL1310110017#
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_03f3416e_3765_4ac0_a730_799010a07488
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q8TCG5
is encoded by: hsa:126129
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: CPT1C

http://identifiers.org/biomodels.db/MODEL1310110017#_a8903222_9d6c_42ec_9628_aa381f94fd82
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:80025
is: Q6P1K9
initial amount: NaN
name: PANK2

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR UMPK
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
is: SBO:0000176
name: UMP kinase
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
is described by: ECO:0000134
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III

metaR GLUTCOADHm
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reactant: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000304
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_6d7d1eb5_895c_43fc_bc3b_aafcf9048b29
is: Q5JAM2
is: SBO:0000252
is encoded by: hsa:211
type: Species
name: ALAS1
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4afb1dbe_5a46_4ed3_a3f1_a307e0318fa1
type: Species
name: HSD3B7
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:80270
boundary condition: true
is: Q9H2F3
initial concentration: NaN

metaM leuktrA4 e
is: HMDB01337
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57463
boundary condition: false
name: leukotriene A4(1-)

metaR LTD4DP
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
name: Leukotriene D4 dipeptidase
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

metaM sbt D e
constant: false
type: Species
is: HMDB00247
initial amount: NaN
boundary condition: false
name: D-glucitol
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_34a42022_c601_4e42_b8d7_0479aceef525
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: SLC24A4
is encoded by: hsa:123041

metaR G6PDH1rer
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#

metaM orot c
is: C00295
boundary condition: false
is: HMDB00226
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: Orotate
is: CHEBI:30839
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

metaM ps hs c
boundary condition: false
name: ps_hs[c]
is: SBO:0000247
type: Species
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaM xylt e
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
is: HMDB02917
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: xylitol
is: SBO:0000247

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM C02528 r
boundary condition: false
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
has only substance units: false
constant: false
is: CHEBI:36234
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR PROGLYPEPT1tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Prolylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM sbt D c
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: D-glucitol
has only substance units: false
is: SBO:0000247
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_47fd9f11_520c_42a8_9f17_4d6c53e26e8c
boundary condition: true
is encoded by: hsa:9057
has only substance units: false
name: SLC7A6
is: SBO:0000252
is: Q92536
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaR r1459
is: SBO:0000185
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110017#
name: Transport reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: true
type: Reaction

metaM dtdp n
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: CHEBI:58369
boundary condition: false
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
constant: false
type: Species

metaM thcholoylcoa x
is: HMDB12456
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial concentration: 1.0
is: CHEBI:27403
initial amount: NaN
boundary condition: false

metaR r2535
is: SBO:0000185
fast: false
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true

metaM so4 c
is: CHEBI:16189
name: sulfate
initial amount: NaN
constant: false
is: HMDB01448
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9d48d6e3_cbab_4230_bbd9_85c69f2f3550
initial amount: NaN
has only substance units: false
name: LDHC
type: Species
initial concentration: NaN
constant: false
is: P07864
is: SBO:0000252
is encoded by: hsa:3948
boundary condition: true

metaR GK1
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
modifier: MODEL1310110017#
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110017#

metaR PPItx
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
fast: false
name: Diphosphate transporter, peroxisome
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction

metaM ksii core4 l
constant: false
name: keratan sulfate II (core 4-linked)
boundary condition: false
has only substance units: false
is: HMDB00189
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
is: CHEBI:57614
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR PAIL HStn
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: true
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
kinetic law: MODEL1310110017#

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR RE2069C
reversible: true
reactant: MODEL1310110017#
fast: false
is: SBO:0000176
type: Reaction
name: RE2069
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_084feff6_168a_49fe_81d5_28aa93130e7e
type: Species
name: CPT1B
constant: false
is: Q53FV7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR RETNt
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
name: retinoic acid transport
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT

metaR RE1254C
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
product: MODEL1310110017#
name: RE1254
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
fast: false
reversible: true

metaR PEt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
name: phosphatidylethanolamine transport
reactant: MODEL1310110017#
type: Reaction

metaM CE2422 m
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
boundary condition: false
is: HMDB11123
has only substance units: false

metaM 7dhchsterol r
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
initial amount: NaN
is: CHEBI:17759
boundary condition: false
initial concentration: 1.0
is: HMDB00032
has only substance units: false
type: Species
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaM pa hs c
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
name: phosphatidate(2-)
is: CHEBI:57739
type: Species

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM CE2435 m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
name: trans,cis-deca-2,4-dienoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_638efe8a_4dc9_4874_b110_ff133e9d6cf9
boundary condition: true
initial amount: NaN
is: P47989
type: Species
constant: false
name: XDH
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7498

metaR r0202
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
reactant: MODEL1310110017#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_3baa57c8_d6eb_443f_8784_287c16a73c88
boundary condition: true
constant: false
is encoded by: hsa:8836
has only substance units: false
initial concentration: NaN
name: GGH
initial amount: NaN
type: Species
is: Q92820
is: SBO:0000252

metaR r0560
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110017#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#

metaM ocdcea l
is: SBO:0000247
name: oleate
constant: false
is: CHEBI:30823
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
is: HMDB00207

metaR CYSSNAT5tc
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM gdp n
is: SBO:0000247
is: CHEBI:58189
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: HMDB01201
has only substance units: false
name: GDP(3-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM dnad c
constant: false
type: Species
boundary condition: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
is: C00857
is: SBO:0000247
is: CHEBI:18304
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01179

metaR PROGLYPRO1c
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylproline in the small intestine for cellular uptake
type: Reaction

metaR TAGt
type: Reaction
reversible: true
fast: false
name: triacylglycerol transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM coa n
is: SBO:0000247
has only substance units: false
is: CHEBI:57287
name: coenzyme A(4-)
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false

metaR r0911
name: Facilitated diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_3f093c70_76d2_407a_8aa5_c31f6acdca66
constant: false
has only substance units: false
is: SBO:0000252
name: GMPR2
is: Q86T14
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51292
type: Species
initial amount: NaN

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r0801
product: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110017#
reversible: true
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaM HC02187 e
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: reverse-triiodthyronine
type: Species
is: CHEBI:28774
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_16009109_aad0_4bda_a9cd_d63682e1a4cf
has only substance units: false
is encoded by: hsa:8527
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: Q16760
type: Species
name: DGKD
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_0c350faa_f991_4287_b744_e8ea411e08cd
is: P17516
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:1109
boundary condition: true
initial concentration: NaN
name: AKR1C4

metaR THBPT4ACAMDASE
reactant: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#

metaR r0994
name: Facilitated diffusion
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM pi e
is: CHEBI:43474
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial concentration: 1.0
is: HMDB00973
is: C00009
boundary condition: false
constant: false

metaR ALDD2xm
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: false
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
product: MODEL1310110017#

metaR H2Otp
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
name: H2O transport, peroxisomal
is: SBO:0000185

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r1658
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#

metaR r1659
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
modifier: MODEL1310110017#

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM acac c
constant: false
is: CHEBI:13705
boundary condition: false
is: HMDB00060
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_83cbf604_6ea7_469b_bce8_8f5d8396d21f
type: Species
name: GAPDH
is: E7EUT4
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:2597
is: SBO:0000252

metaR HGNTOR
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.5
modifier: MODEL1310110017#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110017#

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r0993
is: SBO:0000185
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
fast: false

metaR PGK
fast: false
name: phosphoglycerate kinase
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: true
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.2.3
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110017#_3f4f1703_13bf_40b5_96ef_1b975f8884ac
constant: false
name: _AI091231_1_c
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI091231
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_7ac859d4_5a97_4bf5_b4ff_81b646cbe155
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: AK7
is: Q96M32
is encoded by: hsa:122481

metaM amp r
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: C00020
is: SBO:0000247
constant: false
is: CHEBI:456215
name: AMP
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r0157
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110017#
modifier: MODEL1310110017#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.2
kinetic law: MODEL1310110017#
reversible: false
type: Reaction

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: CHEBI:15355
has only substance units: false
name: acetylcholine
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB00895

http://identifiers.org/biomodels.db/MODEL1310110017#_d8fc36bd_0d8b_45f8_a5e9_0e7a0540ab7f
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: IMPDH1
boundary condition: true
constant: false
is: SBO:0000252
is: B3KRZ3
is encoded by: hsa:3614

metaR RE2655R
product: MODEL1310110017#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
fast: false
name: RE2655

metaM dtdp m
is: HMDB01274
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: dTDP
type: Species
is: CHEBI:58369

metaR RE0453M
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
modifier: MODEL1310110017#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f09cba17_612d_4a6d_891f_6905131adde7
is: Q9UKG4
type: Species
is encoded by: hsa:26266
name: SLC13A4
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ff623697_f101_45f4_b3d3_4372ec08a604
is encoded by: hsa:27068
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: PPA2
initial amount: NaN
is: F8WDN9

metaM dhcrm hs c
name: dihydroceramide
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:31488
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM mescon m
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:36986
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: HMDB00749
name: Mesaconate
constant: false
is: SBO:0000247

metaM ppa e
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
initial amount: NaN
is: CHEBI:17272
name: propionate
initial concentration: 1.0
type: Species

metaM idp e
constant: false
is: HMDB03335
is: CHEBI:58280
name: IDP(3-)
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0

metaM abt e
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01851
is: CHEBI:18403
initial concentration: 1.0
name: L-arabinitol
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR RE2269E
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39

metaR r0913
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#

metaM 3mob e
is: SBO:0000247
type: Species
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: HMDB00019
has only substance units: false

metaR r0870
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.4.13
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
fast: false
name: Facilitated diffusion
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: true
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:

metaR DPCOAPPe
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110017#
name: Pyrophasphatase (dephospho-CoA, extracellular)
fast: false
type: Reaction
product: MODEL1310110017#

metaR r1951
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pi g
boundary condition: false
is: CHEBI:43474
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: hydrogenphosphate
initial concentration: 1.0
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false

metaR r2309
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaR r1656
is: SBO:0000185
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM cdp m
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:58069
type: Species
has only substance units: false
name: CDP(3-)
is: HMDB01546

metaM 34dhpac c
has only substance units: false
name: 3,4-Dihydroxyphenylacetaldehyde
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: CHEBI:27978
is: HMDB03791
initial concentration: 1.0

metaR r0156
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110017#
reversible: false
fast: false

metaR H2Otn
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110017#
name: H2O transport, nuclear
fast: false

metaR DNDPt14m
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000185
name: dUDP transport via dTDP antiport
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110017#

metaM HC01522 c
is: SBO:0000247
type: Species
name: Gentisate aldehyde
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
is: CHEBI:28508
constant: false
boundary condition: false
initial concentration: 1.0

metaR PPItm
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110017#
name: diphopshate transporter, mitochondrial
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_d1f42245_ba69_4b84_890e_82c589bb7ba9
constant: false
name: QDPR
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5860
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P09417

metaM acac e
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
is: HMDB00060
is: CHEBI:13705
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: acetoacetate
initial amount: NaN
boundary condition: false

metaM 3mob c
name: 3-methyl-2-oxobutanoate
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:11851
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR DM dsT antigen g
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM HC01231 c
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
is: CHEBI:58480

http://identifiers.org/biomodels.db/MODEL1310110017#_fda49244_cc86_45a0_a3a0_872d5f33cb18
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: COX6C
is encoded by: hsa:1345
is: P09669
initial concentration: NaN

metaR TCHOLAte
product: MODEL1310110017#
name: bile acid intracellular transport
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4fd3fa9f_0438_45d4_82e6_d8c229076cb1
constant: false
name: ALDOC
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:230
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P09972

http://identifiers.org/biomodels.db/MODEL1310110017#_4a9dcf2a_e40a_4e0a_8db0_a83d8d4e9b44
is encoded by: hsa:953
has only substance units: false
initial amount: NaN
is: Q86VV3
is: SBO:0000252
initial concentration: NaN
name: ENTPD1
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_419d36e5_2825_4622_a3c3_2c8a8b35f2b3
constant: false
is encoded by: hsa:1807
has only substance units: false
is: Q14117
initial concentration: NaN
initial amount: NaN
name: DPYS
is: SBO:0000252
type: Species
boundary condition: true

metaR r1657
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110017#

metaR PGI
reactant: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110017#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.9
is: SBO:0000176
reversible: true
name: glucose-6-phosphate isomerase
modifier: MODEL1310110017#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_4a4eee03_03eb_4619_8582_c70628d4f8be
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: P07451
boundary condition: true
is encoded by: hsa:761
is: SBO:0000252
name: CA3
type: Species

metaM 3mox4hoxm c
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
initial amount: NaN
type: Species
name: 3-Methoxy-4-hydroxymandelate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27622
is: HMDB00291
constant: false
boundary condition: false

metaM abt c
is: CHEBI:18403
constant: false
is: HMDB01851
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: L-arabinitol
type: Species

metaR OBDHc
reversible: false
fast: false
name: 2-Oxobutanoate dehydrogenase, cytosolic
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#

metaR r0009
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
fast: false
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: sialidase, lysosomal
reactant: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176

metaR r1654
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
modifier: MODEL1310110017#

metaR LNLCt
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Linoleic acid (n-C18:2) transport in via diffusion

metaR UDPGLCAter
reversible: true
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
modifier: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110017#

metaR r0354
reversible: false
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_820b5b60_cd38_457f_9aca_936ce9550d5b
initial concentration: NaN
is encoded by: hsa:4830
has part: P22392
constant: false
initial amount: NaN
name: NME1:NME2
has part: P15531
is: SBO:0000297
type: Species
is encoded by: hsa:4831
boundary condition: true
has only substance units: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM pmtcrn r
initial concentration: 1.0
name: L-palmitoylcarnitine
constant: false
type: Species
is: HMDB00222
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

http://identifiers.org/biomodels.db/MODEL1310110017#_79516177_be78_4459_acb8_2bdf9a8f6260
name: IDH2
initial amount: NaN
has only substance units: false
is encoded by: hsa:3418
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: P48735

metaR FOLR2
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
name: folate reductase
modifier: MODEL1310110017#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_64577047_2093_4d04_80d0_597c70977382
type: Species
name: GUSB
initial amount: NaN
is: P08236
constant: false
is encoded by: hsa:2990
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_039b1cff_4039_4b85_9584_cdc434edc018
initial concentration: NaN
constant: false
is: P49914
type: Species
is: SBO:0000252
is encoded by: hsa:10588
initial amount: NaN
name: MTHFS
has only substance units: false
boundary condition: true

metaR RE0453N
kinetic law: MODEL1310110017#
name: RE0453
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR VITD3t2
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
name: Vitamin D3 uptake
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_8c7766b9_b005_4536_8b9e_f4b4a8717771
type: Species
name: EHHADH
is: Q9NY65
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1962
has only substance units: false
initial amount: NaN

metaR r1655
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_f3f20305_b5c0_41f8_bd45_e6055af6bef0
initial concentration: NaN
name: CPT1B
constant: false
is: E9PCP2
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1375

metaR H2Otm
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
name: H2O transport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reversible: true
fast: false

metaM cdp n
initial concentration: 1.0
name: CDP(3-)
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:58069

metaR r2308
kinetic law: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_43410140_8fe8_45ea_a26d_37726b86134a
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79646
name: PANK3
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9H999

metaM leuktrB4 e
name: leukotriene B4(1-)
is: HMDB01085
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
is: CHEBI:57461

http://identifiers.org/biomodels.db/MODEL1310110017#_fa1c8818_2807_4618_922e_606dbf2dca3d
initial amount: NaN
constant: false
has only substance units: false
name: _AI345944_1_m
is encoded by: hsa:AI345944
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM HC02216 e
initial concentration: 1.0
name: prostaglandin-f2beta
is: CHEBI:28922
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
initial amount: NaN
type: Species

metaM ethamp c
type: Species
is: CHEBI:58190
name: ethamp[c]
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
constant: false
is: HMDB00224
initial amount: NaN

metaM fmn c
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: FMN
is: SBO:0000247
is: C00061
initial amount: NaN
is: HMDB01520

metaR PPItr
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR CYTDt4
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110017#
fast: false
name: cytidine transport in via sodium symport
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_efc43cfb_b548_481e_9d0d_67ba7e963ad8
name: _AI024818_1_c
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI024818
initial amount: NaN
has only substance units: false

metaM coa l
initial amount: NaN
boundary condition: false
name: coenzyme A(4-)
is: CHEBI:57287
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110017#_ea8d2cac_cde9_4290_a5c7_0b3cfc650644
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: RDH14
is: Q9HBH5
constant: false
is encoded by: hsa:57665

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_efaec661_9606_4303_bed4_6f5e6745f6e8
is: SBO:0000252
is encoded by: hsa:765
constant: false
is: Q5FC00
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: CA6

http://identifiers.org/biomodels.db/MODEL1310110017#_44b439ec_e70c_4fac_a8ad_a56bfa865512
boundary condition: true
name: ACOT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:641371
constant: false
is: E9KL42

metaM thp2c c
has only substance units: false
name: 1-piperideine-6-carboxylate
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB12130
is: CHEBI:16987

metaR r1652
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaM ibcoa m
initial amount: NaN
has only substance units: false
is: HMDB01243
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57338
constant: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)

metaR NACHORCTL3le
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_d1092f77_7739_4634_80c3_601027275310
constant: false
name: CHAT
has only substance units: false
initial amount: NaN
is: P28329
initial concentration: NaN
is encoded by: hsa:1103
boundary condition: true
type: Species
is: SBO:0000252

metaM HC02216 c
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
constant: false
has only substance units: false
is: CHEBI:28922
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-f2beta
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7fefca4c_6c6d_4d1a_826e_cde15e21ec32
initial concentration: NaN
is encoded by: hsa:AI697028
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: _AI697028_1_e

http://identifiers.org/biomodels.db/MODEL1310110017#_d2fe3796_1425_4ab4_a598_160a3bcdeb46
name: RPE
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q96AT9
type: Species
boundary condition: true
is encoded by: hsa:6120

metaM coa m
is: HMDB01423
has only substance units: false
is: SBO:0000247
is: C00010
boundary condition: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: CHEBI:57287
initial concentration: 1.0
initial amount: NaN
constant: false

metaM acetone m
is: CHEBI:15347
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
name: acetone
is: SBO:0000247
initial concentration: 1.0
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaR RE2541E
name: RE2541
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110017#

metaR r1653
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_d71c103d_1d5b_4734_9c61_3e5ca3b00c0d
is encoded by: hsa:55293
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: UEVLD
is: Q8IX04

metaM thyox L c
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
name: L-thyroxine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:18332
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_00d1e020_9803_4f01_8862_881ea7890a90
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI694761_1_c
constant: false
is encoded by: hsa:AI694761
has only substance units: false
type: Species
is: SBO:0000252

metaR r0355
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
type: Reaction
is: SBO:0000176

metaM dchac e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00626
notes: FORMULA: C24H39O4 CHARGE: -1
type: Species
name: deoxycholic acid

metaR r1730
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110017#_84afc5e2_545e_420a_85ac_0bd2d843f3b9
is: SBO:0000252
is encoded by: hsa:6580
is: O15245
has only substance units: false
name: SLC22A1
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4a6357a4_5863_48bd_8841_977d2f1b914b
name: SLCO2A1
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q92959
is encoded by: hsa:6578
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0642
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110017#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000

metaR r1650
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5bd8eaa4_a42a_450a_8189_331c1bff3fbd
name: SLC25A16
is: SBO:0000252
constant: false
initial concentration: NaN
is: P16260
initial amount: NaN
boundary condition: true
is encoded by: hsa:8034
type: Species
has only substance units: false

metaR 34DHPLACOX
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110017#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
reversible: false

metaR CYTK1
reversible: true
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP)
fast: false
type: Reaction

metaM gchola e
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00138
has only substance units: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0

metaM 13dampp c
initial amount: NaN
is: CHEBI:57484
has only substance units: false
type: Species
name: trimethylenediaminium
is: HMDB00002
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
boundary condition: false
constant: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR CO2tm
product: MODEL1310110017#
is: SBO:0000185
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF

metaR DM anth
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR UGT1A10r
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000134
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17

metaR RE0453C
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
name: RE0453
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000176

metaR PPAer
fast: false
is described by: ECO:0000304
is: SBO:0000176
name: inorganic diphosphatase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.9
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (2538.1) or (92579.1) or (57818.1) SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 2 AUTHORS: NOTES:IF
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_7606b942_90b1_4ff9_b5a4_c9030d6ceed2
initial concentration: NaN
is: E9PCX6
name: ASNS
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:440
initial amount: NaN
is: SBO:0000252

metaR RE1534M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: RE1534
kinetic law: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c3d32a6e_92b9_49e7_b94a_d00b97ec0bfc
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: GGT7
is encoded by: hsa:2686
is: A0PJJ9
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_52848d0d_f44b_4bcd_9554_1049339d9f97
boundary condition: true
is encoded by: hsa:50484
initial amount: NaN
is: Q7LG56
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: RRM2B

metaM HC02175 c
is: CHEBI:27689
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
constant: false

metaM dtdp e
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
initial concentration: 1.0
is: CHEBI:58369
constant: false
is: HMDB01274

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r1651
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000000

metaM inost e
is: CHEBI:17268
is: SBO:0000247
is: HMDB00211
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_841cd607_4497_406e_8dba_782f8855eaf2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:53354
is: Q8TE04
constant: false
name: PANK1
initial concentration: NaN

metaM thyox L e
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00248
has only substance units: false
constant: false
is: CHEBI:18332
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_4b097ff1_7c7e_40f9_b2ca_12da94656498
initial concentration: NaN
is encoded by: hsa:AI378339
name: _AI378339_1_m
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_7cd0a70d_eb23_4577_a471_04293a117a3b
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6120
name: RPE
is: Q53TV9
constant: false
initial concentration: NaN
boundary condition: true

metaM HC01842 c
initial amount: NaN
name: Phosphodimethylethanolamine
type: Species
has only substance units: false
is: CHEBI:31997
boundary condition: false
constant: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_f201a951_bd48_49a6_813f_e2a3748f3160
is encoded by: hsa:4668
initial concentration: NaN
constant: false
initial amount: NaN
is: P17050
has only substance units: false
type: Species
name: NAGA
is: SBO:0000252
boundary condition: true

metaM HC02210 c
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: SBO:0000247
name: prostaglandin-d3
initial amount: NaN

metaM 3mob m
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:11851
constant: false
type: Species
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaR CYTK3
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
modifier: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
fast: false
kinetic law: MODEL1310110017#

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110017#
reversible: true
name: K+-Cl- cotransporter (NH4+)

http://identifiers.org/biomodels.db/MODEL1310110017#_28f31a9f_e2ee_487e_bf69_13e3b0e53d76
is encoded by: hsa:292
has only substance units: false
boundary condition: true
constant: false
is: Q6NVC0
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC25A5

metaR PYNP2r
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction

metaR TREHe
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
modifier: MODEL1310110017#
fast: false
reversible: false
name: alpha,alpha-trehalase

metaR NACHEXA20ly
modifier: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110017#_6f2fa0a6_b637_4aa9_8de5_070423bb160f
constant: false
has only substance units: false
name: ACPP
is encoded by: hsa:55
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: P15309
boundary condition: true

metaM gumtchol e
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
initial amount: NaN
is: HMDB00626
initial concentration: 1.0
name: guar gum-taurocholic acid complex
has only substance units: false

metaR r0641
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.2.4
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_981d4c3e_cdba_43d2_b76a_b768606938f5
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: _D87002_1_e
is encoded by: hsa:D87002
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_bc3a254e_da59_45f6_86f4_9f1fde5f1156
type: Species
name: ADH1B
is: P00325
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:125
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_855dc1ad_1247_496d_b509_51cd4908e804
name: _AI373818_1_m
is encoded by: hsa:AI373818
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaM leuktrB4 c
is: HMDB01085
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: CHEBI:57461
is: SBO:0000247
name: leukotriene B4(1-)
has only substance units: false

metaM HC02175 e
is: CHEBI:27689
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
name: caprate
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_7723c356_3825_4d5d_b7b8_99bcc7785433
constant: false
is encoded by: hsa:9154
initial concentration: NaN
has only substance units: false
name: SLC28A1
boundary condition: true
is: O00337
type: Species
initial amount: NaN
is: SBO:0000252

metaR CYTK2
type: Reaction
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
name: cytidylate kinase (dCMP)
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_dd191e2c_c5eb_4cef_a9a6_7c933f93ab26
is: SBO:0000252
is encoded by: hsa:8836
constant: false
has only substance units: false
initial concentration: NaN
is: Q92820
name: GGH
initial amount: NaN
type: Species
boundary condition: true

metaR r0002
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
reversible: true
kinetic law: MODEL1310110017#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#

metaM bildglcur e
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03325
is: CHEBI:58471
constant: false
name: bis(beta-glucosyluronate)bilirubin
boundary condition: false

metaM ump c
initial amount: NaN
name: UMP
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB00288
is: C00105
is: SBO:0000247
has only substance units: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR H2Otg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
name: H2O transport, Golgi apparatus
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_7793daba_0ea2_4d19_8be0_27cde788509a
is: P30613
constant: false
name: PKLR
has only substance units: false
is encoded by: hsa:5313
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR RE3326M
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110017#
name: RE3326
reactant: MODEL1310110017#

metaM dtdp c
boundary condition: false
is: HMDB01274
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
is: CHEBI:58369
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: C00363
has only substance units: false

metaM hista e
type: Species
has only substance units: false
constant: false
name: histamium
is: SBO:0000247
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR FTHFLm
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is: SBO:0000176
product: MODEL1310110017#
name: formate-tetrahydrofolate ligase, mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
reversible: true
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#

metaR MACACI
type: Reaction
name: maleylacetoacetate isomerase
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110017#

metaM adp n
is: HMDB01341
boundary condition: false
name: ADP(3-)
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
is: CHEBI:456216
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_75e9a787_b0b0_403f_8ab6_1300bc05d7c0
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9UI40
name: SLC24A2
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:25769

metaM HC02210 e
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
type: Species
name: prostaglandin-d3
is: SBO:0000247
has only substance units: false

metaM HC01444 e
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: CHEBI:15754
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Galactosylglycerol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_3f6c6fb8_73a0_4802_a254_aae2954880e5
is: Q8N4A0
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8693
name: GALNT4
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_c090f212_1035_4ab2_ba03_1b3499d796e7
is encoded by: hsa:27068
name: PPA2
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q9H2U2
is: SBO:0000252
type: Species

metaM crmp hs c
name: ceramide 1-phosphate(2-)
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57674
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_835b8cc6_a97d_4ebf_a034_8a6489b671a9
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6005
has only substance units: false
is: Q96E98
boundary condition: true
is: SBO:0000252
name: RHAG

metaR r1148
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110017#
name: Active transport
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction

metaM idp c
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: IDP(3-)
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaR 5MTHFt
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000269
type: Reaction

metaR ORNt3m
name: ornithine mitochondrial transport via proton antiport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
product: MODEL1310110017#
is described by: ECO:0000269
fast: false

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: C00010
has only substance units: false
constant: false
is: CHEBI:3312
initial concentration: 1.0
is: HMDB01423
type: Species
name: Coenzyme A
initial amount: NaN

metaR ASNt4
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: L-asparagine transport in via sodium symport
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00195
is: CHEBI:17596
type: Species
is: C00294
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ed18b72e_707a_465f_a41d_11031b4fced7
boundary condition: true
is encoded by: hsa:R39999
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: _R39999_1_c
has only substance units: false
constant: false

metaM prostgh2 c
initial concentration: 1.0
is: HMDB01381
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
is: SBO:0000247
is: CHEBI:57405
name: prostaglandin H2(1-)
initial amount: NaN

metaM C02528 e
type: Species
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
boundary condition: false
is: CHEBI:36234
constant: false
is: HMDB00518
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR 3SALATAi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: 3-sulfino-alanine transaminase (irreversible)
product: MODEL1310110017#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
kinetic law: MODEL1310110017#

metaR KYNAKGAT
type: Reaction
fast: false
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_8f8ae44d_40ad_4725_95ab_24c16e4adf25
is encoded by: hsa:2806
is: P00505
is: SBO:0000252
type: Species
has only substance units: false
name: GOT2
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_5971999a_1512_49c9_a888_39d0cc9d1b76
name: _AI697028_1_m
type: Species
boundary condition: true
is encoded by: hsa:AI697028
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r1147
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
is: SBO:0000176
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction

metaM bildglcur c
is: CHEBI:58471
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB03325
type: Species
boundary condition: false
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR CO2tp
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110017#
type: Reaction
fast: false
reversible: true
name: CO2 peroxisomal transport
product: MODEL1310110017#

metaM hista c
is: SBO:0000247
is: HMDB00870
name: histamium
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58432
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
constant: false

metaM amp m
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: AMP(2-)
type: Species
is: HMDB00045
initial amount: NaN
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaM gchola c
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:58235
name: glycocholate
initial amount: NaN
boundary condition: false
is: HMDB00138
constant: false
is: SBO:0000247

metaM crmp hs e
name: ceramide 1-phosphate(2-)
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57674
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960

metaR RE3627M
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000176
name: RE3627
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: true

metaR r0426
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.34
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110017#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
fast: false

metaR CYSTGLUex
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: L-cystine/L-glutamate exchanger
kinetic law: MODEL1310110017#

metaM pi c
notes: FORMULA: HO4P CHARGE: -2
initial amount: NaN
is: C00009
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: hydrogenphosphate
is: HMDB00973
type: Species
is: CHEBI:43474

metaR 3HKYNAKGAT
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false

metaR GLYt4
reversible: false
product: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
name: glycine transport via sodium symport
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible

http://identifiers.org/biomodels.db/MODEL1310110017#_274c3ca3_e928_459a_864b_97974e198e46
is encoded by: hsa:52
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: ACP1
initial amount: NaN
is: Q59EH3

metaR DRPA
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
name: deoxyribose-phosphate aldolase
type: Reaction

metaR DM atp c
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110017#
reversible: false
kinetic law: MODEL1310110017#
type: Reaction
name: DM_atp(c)
is: SBO:0000176
fast: false
product: MODEL1310110017#

metaM inost c
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
name: myo-inositol
is: CHEBI:17268
constant: false
initial concentration: 1.0
is: HMDB00211
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5bce9030_07c7_435a_bf56_c3c46005c7dd
is encoded by: hsa:2882
is: SBO:0000252
is: Q96SL4
constant: false
name: GPX7
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR r2390
reversible: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_1840a63a_03bb_47d6_a806_6e38e982ef07
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8K3J4
initial concentration: NaN
name: CA14
constant: false
is encoded by: hsa:23632
type: Species
is: SBO:0000252

metaM ins e
initial amount: NaN
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
initial concentration: 1.0
is: CHEBI:17596
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00195
type: Species
is: C00294

metaM adp m
is: http://identifiers.org/pubchem.compound/3310
constant: false
initial concentration: 1.0
is: HMDB01341
type: Species
is: C00008
initial amount: NaN
is: CHEBI:456216
is: SBO:0000247
has only substance units: false
name: ADP
boundary condition: false

metaR FAOXC12C10m
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR r0093
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000176
fast: false
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45

metaM prostgh2 e
is: HMDB01381
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
has only substance units: false
initial amount: NaN
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110017#_e30ffb6f_cfad_4e55_8d9e_bf9d9d2c43bb
is encoded by: hsa:23057
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9BZQ4
name: NMNAT2
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM C02528 c
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:36234
has only substance units: false
constant: false
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
is: SBO:0000247

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM 5fthf m
is: HMDB01562
is: CHEBI:57457
name: 5-formyltetrahydrofolate(2-)
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR CYTK9
type: Reaction
reactant: MODEL1310110017#
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000269
reversible: true

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_4b7574c7_4ff7_4940_b1e2_46c61894171c
is encoded by: hsa:229
is: SBO:0000252
boundary condition: true
is: P05062
constant: false
has only substance units: false
name: ALDOB
initial concentration: NaN
initial amount: NaN
type: Species

metaM CE0693 m
is: SBO:0000247
is: HMDB11123
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA
type: Species
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693

metaR r0575
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110017#
reversible: true
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is: SBO:0000176

metaM HC01223 m
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
has only substance units: false
is: CHEBI:57340

metaR S6TASE22ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110017#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR Htr
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110017#
name: H transporter, endoplasmic reticulum
fast: false

metaM 5dhf l
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB06487
initial concentration: 1.0
initial amount: NaN
name: pentaglutamyl folate (DHF)
has only substance units: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

metaR r2521
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
type: Reaction
name: Utilized transport
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR r1156
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is: SBO:0000176
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110017#_93ca4d7d_2dba_4a77_bc68_70e105ad9dce
initial amount: NaN
name: BCKDHB
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:594
has only substance units: false
initial concentration: NaN
is: P21953

metaM leu L m
is: HMDB00687
name: L-leucine
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:15603
type: Species

metaM Tn antigen l
constant: false
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: Tn antigen
is: SBO:0000247

metaR ACOAD8m
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.10
product: MODEL1310110017#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4b3c645d_ae9f_45bb_89ad_e2116aa85dfd
is: SBO:0000252
initial amount: NaN
name: HSD3B1
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3283
is: P14060

metaR r0424
reversible: true
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_302ecea5_5edb_4d10_9d8f_3b569a5e6b3a
boundary condition: true
initial amount: NaN
constant: false
name: _U37519_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_98e8f5d2_26f2_40ff_a821_690ef40212af
is: Q6ZMR3
type: Species
is encoded by: hsa:160287
has only substance units: false
boundary condition: true
name: LDHAL6A
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1255
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
reversible: false
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_0775d5cc_c1e1_45c0_ae3e_568f62baa83f
is: SBO:0000252
is encoded by: hsa:3158
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HMGCS2
is: P54868
constant: false

metaM dhf m
is: HMDB01056
type: Species
is: SBO:0000247
boundary condition: false
name: dihydrofolate(2-)
constant: false
is: CHEBI:57451
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110017#_37025dcb_8936_4d84_ac7f_1556958d5a54
initial concentration: NaN
is: P07203
initial amount: NaN
name: GPX1
has only substance units: false
constant: false
is encoded by: hsa:2876
boundary condition: true
type: Species
is: SBO:0000252

metaM 5dhf m
type: Species
is: HMDB06487
initial amount: NaN
name: pentaglutamyl folate (DHF)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_41c902b4_8452_4585_9d3d_b1849c8efcd4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: C9JZ62
is encoded by: hsa:641649
type: Species
initial amount: NaN
name: TMEM91

metaM uacgam r
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00290
is: SBO:0000247
has only substance units: false
type: Species

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110017#
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176

metaR r0423
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110017#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM odecoa r
constant: false
is: HMDB01322
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57387
has only substance units: false
name: oleoyl-CoA(4-)
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial concentration: 1.0

metaM dhf l
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: dihydrofolate(2-)
initial amount: NaN
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
is: HMDB01056
initial concentration: 1.0

metaR LACLt
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
reversible: false
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000134
fast: false
name: Lactate transport
type: Reaction

metaM ala L m
name: L-alanine
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16977
is: SBO:0000247
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

http://identifiers.org/biomodels.db/MODEL1310110017#_87d6fb0b_bf71_456a_bc46_65bc921dc06f
is encoded by: hsa:766
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: CA7
type: Species
constant: false
is: Q86YU0
is: SBO:0000252
has only substance units: false

metaR PGPP hs
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.27 Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
name: Phosphatidylglycerol phosphate phosphatase (homo sapiens)
fast: false

metaR biomass reaction
fast: false
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: false
name: biomass_reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM anth e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0
is: HMDB01123
has only substance units: false
name: anthranilate
type: Species
is: CHEBI:16567
constant: false
boundary condition: false

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
boundary condition: false
constant: false
is: HMDB02329
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_d8d41922_4834_4cc7_95d3_19d152e3e5f2
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: Q99798
name: ACO2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50
constant: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_7671afaf_9feb_4146_ba27_5d2158fe06dd
is: Q9NPB1
is encoded by: hsa:56953
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: NT5M
has only substance units: false
initial concentration: NaN

metaR r0422
product: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaR r0578
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110017#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5d1ec8b3_ff93_4dcb_83b2_eac166beda0b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:64077
constant: false
boundary condition: true
is: Q9H008
type: Species
name: LHPP

metaR CHLPCTD
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: choline phosphate cytididyltransferase
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.15
reversible: false
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM pi x
has only substance units: false
is: HMDB00973
constant: false
initial amount: NaN
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: SBO:0000247
is: CHEBI:43474
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_8f31b310_3c79_4fa6_b0bb_9400c908ff93
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CERK
constant: false
type: Species
boundary condition: true
is encoded by: hsa:64781
initial concentration: NaN

metaR RE0935E
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110017#
modifier: MODEL1310110017#
name: RE0935
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR ACETONEt2m
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110017#
name: acetone mitochondrial transport via proton symport
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

metaR r0647
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Spontaneous reaction
fast: false
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM dadp m
boundary condition: false
constant: false
type: Species
is: HMDB01508
name: dADP(3-)
is: SBO:0000247
is: CHEBI:57667
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0

metaM amp e
boundary condition: false
is: C00020
type: Species
name: AMP
initial concentration: 1.0
is: HMDB00045
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: CHEBI:456215
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_46d02a86_7eda_44aa_b950_617ddd46353e
initial amount: NaN
constant: false
initial concentration: NaN
name: BCKDHB
type: Species
is: P21953
boundary condition: true
has only substance units: false
is encoded by: hsa:594
is: SBO:0000252

metaM ump e
is: CHEBI:57865
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
name: UMP(2-)
initial concentration: 1.0
is: HMDB00288
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f2a6af2d_c9f1_44ee_9018_8f3982dd10b3
is: Q10471
initial amount: NaN
boundary condition: true
has only substance units: false
name: GALNT2
type: Species
constant: false
is encoded by: hsa:2590
initial concentration: NaN
is: SBO:0000252

metaR CYTK4
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: cytidylate kinase (dCMP)(GTP)
fast: false

metaR r1464
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
name: Active transport
is: SBO:0000185
kinetic law: MODEL1310110017#

metaR Htx
type: Reaction
name: H transporter, peroxisome
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#

metaR DURItn
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110017#
name: deoxyuridine transport in nucleus
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_54e3a65c_5f39_4e49_95e9_0330c4225ec5
boundary condition: true
is: P48067
has only substance units: false
is encoded by: hsa:6536
type: Species
constant: false
initial concentration: NaN
name: SLC6A9
is: SBO:0000252
initial amount: NaN

metaM gmp c
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00144
is: HMDB01397
boundary condition: false
type: Species
is: CHEBI:58115
name: GMP

http://identifiers.org/biomodels.db/MODEL1310110017#_4fdbab4a_c824_44aa_8f60_2f223816c7cf
boundary condition: true
has only substance units: false
name: _AI348006_1_c
is: SBO:0000252
is encoded by: hsa:AI348006
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0579
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110017#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176

metaM anth c
boundary condition: false
initial amount: NaN
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01123
initial concentration: 1.0

metaM dadp n
has only substance units: false
constant: false
name: dADP(3-)
type: Species
is: HMDB01508
is: SBO:0000247
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM leuktrF4 c
boundary condition: false
name: leukotriene F4
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false
initial amount: NaN
is: HMDB06465
is: CHEBI:27491
initial concentration: 1.0

metaM dhdascb c
is: SBO:0000247
is: CHEBI:58070
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
type: Species
constant: false
has only substance units: false
name: dehydroascorbide(1-)
is: HMDB01264

metaR CYTK5
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (dCMP)
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reversible: true

metaR CYTK7n
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_68965ced_3284_451f_a383_2b7a92f311ea
has only substance units: false
type: Species
initial amount: NaN
is: B2RB13
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23305
name: ACSL6

metaM Tn antigen g
name: Tn antigen
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C04383
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_bb569684_6669_4417_8d8f_7dfc5fdf172f
is encoded by: hsa:280
type: Species
boundary condition: true
has only substance units: false
name: AMY2B
initial amount: NaN
is: SBO:0000252
is: P19961
initial concentration: NaN
constant: false

metaR AGDC
reactant: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.25
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
name: N-acetylglucosamine-6-phosphate deacetylase
reversible: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_75179773_d20f_4962_98c6_d6086f6c4902
name: _AI761708_1_m
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI761708
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_a45987f9_760d_482e_a61a_1d5b556aefc0
is encoded by: hsa:HG2846-HT2983
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _HG2846_HT2983_1_c
boundary condition: true
initial amount: NaN
constant: false

metaR SERGLYexR
product: MODEL1310110017#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000304
name: L-Serine/Glycine reversible exchange
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_421b44d3_7617_429b_99e8_d29058bab399
type: Species
is: SBO:0000252
has only substance units: false
is: Q9HBF5
constant: false
is encoded by: hsa:400410
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ST20

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR PROSTGI2t
kinetic law: MODEL1310110017#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM amp c
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP
is: C00020
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:3322
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110017#_e3d79b89_d3a8_4abc_9069_52afe721b611
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: COX1
boundary condition: true
type: Species
is encoded by: hsa:4512
is: Q7GXY8

http://identifiers.org/biomodels.db/MODEL1310110017#_9fd651cd_8789_4381_8ba4_247bede28392
is: SBO:0000252
boundary condition: true
is encoded by: hsa:145226
has only substance units: false
initial concentration: NaN
name: RDH12
initial amount: NaN
is: Q96NR8
type: Species
constant: false

metaM ump g
type: Species
name: UMP(2-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: HMDB00288
constant: false
initial concentration: 1.0

metaM dha e
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01882
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: SBO:0000247
name: glycerone
is: CHEBI:16016
initial concentration: 1.0
has only substance units: false
type: Species

metaR CYTK6
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110017#
fast: false
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e90596c3_f501_4719_b42c_c1acc920dcc8
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348

metaR r2419
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
product: MODEL1310110017#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_003dabe7_768c_4882_939b_994ad764615d
has only substance units: false
is encoded by: hsa:8867
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: C9JFZ1
constant: false
initial amount: NaN
name: SYNJ1

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR CYTK8
modifier: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: cytidylate kinase (CMP,dATP)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110017#
fast: false

metaR r1154
is described by: ECO:0000000
name: EC:1.2.7.2
product: MODEL1310110017#
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reactant: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_487d69fe_621f_4080_9054_92f1deadc998
constant: false
initial amount: NaN
has only substance units: false
name: PCYT1A
type: Species
is encoded by: hsa:5130
is: P49585
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_d0ff81f5_2a64_4dda_a7db_0c9bcddd9b22
is: SBO:0000252
name: PPCDC
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q96CD2
boundary condition: true
is encoded by: hsa:60490

metaR OCDCEAtr
reactant: MODEL1310110017#
product: MODEL1310110017#
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110017#
type: Reaction

metaR RE1517M
type: Reaction
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: true
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000

metaR CYTK7
reversible: true
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)

metaR r0644
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#

metaM HC02217 e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:27647
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7645fd59_235b_4800_b08f_36d00c762816
is: SBO:0000252
is encoded by: hsa:10935
initial amount: NaN
constant: false
is: E9PH29
name: PRDX3
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_21cb6a00_5323_45b6_926d_6313c5a31ae2
boundary condition: true
initial concentration: NaN
is: P00441
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6647
initial amount: NaN
has only substance units: false
name: SOD1

metaM adp c
is: HMDB01341
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
type: Species
is: C00008
initial amount: NaN
name: ADP
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaM leu L c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: L-leucine
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:15603
is: HMDB00687
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaM bhb m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:10983
initial amount: NaN
is: HMDB00011
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
boundary condition: false
type: Species

metaM rbt e
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
is: SBO:0000247
is: CHEBI:15963
is: HMDB00508
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM acac m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
constant: false
is: CHEBI:13705
is: HMDB00060
name: acetoacetate
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_099cd2a9_f452_49a2_ac21_53029e907eb6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2954
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: GSTZ1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_02c9c822_b244_48d0_82d7_bdae5c84dd18
name: _H17063_1_c
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H17063
initial amount: NaN
type: Species

metaR r0908
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true

metaM bilglcur c
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
is: CHEBI:57767
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r2102
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_fdf3128a_78a2_42e5_b2fe_a589587b608c
initial amount: NaN
boundary condition: true
type: Species
is: E7EQF2
name: CROT
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:54677

http://identifiers.org/biomodels.db/MODEL1310110017#_ac755fed_e94f_4526_b634_63c330d8d06d
constant: false
is encoded by: hsa:23657
name: SLC7A11:SLC3A2
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: Q9UPY5

metaM pi l
has only substance units: false
name: hydrogenphosphate
initial concentration: 1.0
is: CHEBI:43474
type: Species
is: HMDB00973
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110017#_7fb6a4fc_42f7_4caa_bb28_2a4a4d63a3db
is encoded by: hsa:953
constant: false
initial amount: NaN
boundary condition: true
name: ENTPD1
is: SBO:0000252
type: Species
is: Q86VV3
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_0159a9da_f8f2_4ec6_9f63_494090191cd6
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:48
initial amount: NaN
type: Species
name: ACO1
is: P21399

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
fast: false
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000

metaM dhf c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
is: C00415
is: HMDB01056
type: Species
boundary condition: false
has only substance units: false
name: 7,8-Dihydrofolate
is: CHEBI:57451
constant: false

metaM trp L e
is: HMDB00929
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: L-tryptophan
boundary condition: false
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
has only substance units: false
type: Species

metaM dutp m
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
name: dUTP
is: CHEBI:17625
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_f4751a01_0280_42d7_8056_1088c31adbd7
initial concentration: NaN
is: P53597
name: SUCLG1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8802
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM pi m
is: HMDB00973
boundary condition: false
type: Species
initial amount: NaN
name: hydrogenphosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
has only substance units: false

metaR r2101
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
is: CHEBI:57344
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: SBO:0000247
is: HMDB01493
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_1ce125e0_0da1_4ad2_a7b2_d0c1e888158e
is encoded by: hsa:1608
constant: false
is: SBO:0000252
initial concentration: NaN
is: P49619
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: DGKG

metaM leu L e
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
initial concentration: 1.0
name: L-leucine
has only substance units: false
boundary condition: false
is: CHEBI:15603
is: HMDB00687
type: Species
initial amount: NaN

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM dcholcoa x
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
type: Species
name: chenodeoxycholoyl coenzyme a
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110017#_8cffb632_b536_46a9_9a27_0d7903fcb62f
initial concentration: NaN
type: Species
has part: P07686
has only substance units: false
boundary condition: true
has part: P06865
is encoded by: hsa:3074
is encoded by: hsa:3073
is: SBO:0000297
initial amount: NaN
constant: false
name: HEXA:HEXB

metaR r1734
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false
type: Reaction

metaR CYTK12n
type: Reaction
fast: false
name: cytidylate kinase (dCMP,dCTP),nuclear
kinetic law: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
reactant: MODEL1310110017#

metaM rbt c
name: D-ribitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
has only substance units: false
is: CHEBI:15963
is: SBO:0000247
boundary condition: false
is: HMDB00508
initial amount: NaN
initial concentration: 1.0

metaR CHLtm
fast: false
reactant: MODEL1310110017#
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57767
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_06ec62b7_ca0e_4a4c_a63e_ebf0bc429a70
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: _NM_013421_1_e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:NM 013421
initial amount: NaN

metaM 5dhf e
constant: false
type: Species
name: pentaglutamyl folate (DHF)
initial amount: NaN
is: SBO:0000247
is: HMDB06487
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110017#_866c4826_a5f8_4356_87d5_b03eb5ab2ff8
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:9963
name: SLC23A1
is: Q9UHI7
boundary condition: true
initial concentration: NaN
constant: false

metaR r0999
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
product: MODEL1310110017#
reversible: true
is: SBO:0000185

metaR r2100
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_2ede97ec_c25a_48a8_8246_c06bf1956f7c
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474
initial concentration: 1.0
type: Species
is: HMDB00973
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM CE2420 m
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
constant: false
is: HMDB11123
initial amount: NaN

metaR GCHOLAte
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: bile acid intracellular transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reactant: MODEL1310110017#
reversible: true
is: SBO:0000185

metaR ECOAH12m
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110017#
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110017#
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
is: SBO:0000176

metaR r0160
reactant: MODEL1310110017#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
type: Reaction
product: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reversible: false
is: SBO:0000176

metaM ump r
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: HMDB00288
initial amount: NaN
name: UMP
is: CHEBI:57865
initial concentration: 1.0

metaM retinal 11 cis c
is: HMDB02152
initial amount: NaN
type: Species
is: SBO:0000247
name: 11-cis-retinal
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

metaR r0570
is version of: http://identifiers.org/ec-code/6.3.3.2
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:

metaM trp L c
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
is: HMDB00929
has only substance units: false
initial concentration: 1.0
is: CHEBI:16828
type: Species
initial amount: NaN
constant: false
name: L-tryptophan

http://identifiers.org/biomodels.db/MODEL1310110017#_32c3d56c_6a30_4b39_aba3_27aede63cb59
name: _AI769281_1_e
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AI769281
has only substance units: false

metaR r0909
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Transport reaction
reversible: true

metaR r1150
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110017#
name: Facilitated diffusion
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_a2966a50_d9aa_4c3d_b757_e314c238d85d
type: Species
initial concentration: NaN
is encoded by: hsa:8612
is: E9PAY8
boundary condition: true
is: SBO:0000252
name: PPAP2C
constant: false
has only substance units: false
initial amount: NaN

metaM leuktrF4 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
name: leukotriene F4
is: HMDB06465
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27491

metaM coa x
is: C00010
is: CHEBI:57287
has only substance units: false
constant: false
boundary condition: false
is: HMDB01423
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: SBO:0000247

metaR O2tp
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: O2 transport, peroxisomal
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110017#
fast: false

metaM itp n
name: ITP(3-)
initial concentration: 1.0
is: HMDB00189
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57614
is: SBO:0000247

metaM i c
initial amount: NaN
is: SBO:0000247
constant: false
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:16382
boundary condition: false
is: HMDB12238

metaM acetone c
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: acetone
type: Species
is: HMDB01659
is: CHEBI:15347
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207

metaR L LACt2r
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: L-lactate reversible transport via proton symport
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
kinetic law: MODEL1310110017#

metaR r1950
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#

metaR DHFtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
is: SBO:0000185
name: dihydrofolate reversible lysosomal transport
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
is described by: ECO:0000000

metaM HC01231 m
constant: false
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58480
has only substance units: false
type: Species
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate

http://identifiers.org/biomodels.db/MODEL1310110017#_df362ca9_77c0_4326_a8b8_92aa891f1e28
boundary condition: true
initial amount: NaN
is: P15104
initial concentration: NaN
is: SBO:0000252
name: GLUL
is encoded by: hsa:2752
type: Species
constant: false
has only substance units: false

metaR r2526
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_140b616b_d8ba_43f0_a77d_259dd46553fe
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:2222
type: Species
initial amount: NaN
name: FDFT1
is: P37268

metaR ACGAMK
fast: false
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is: SBO:0000176
name: N-acetylglucosamine kinase
is described by: ECO:0000269
product: MODEL1310110017#

metaR DNDPt36m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
name: dGDP transport via dCDP antiport
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_50085fde_c199_4b24_9aca_acdbd44373df
has only substance units: false
is: O95907
constant: false
is encoded by: hsa:23539
is: SBO:0000252
initial concentration: NaN
name: SLC16A8
initial amount: NaN
type: Species
boundary condition: true

metaM 3m4hpga c
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: HMDB04061
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: http://identifiers.org/pubchem.compound/7909

http://identifiers.org/biomodels.db/MODEL1310110017#_817ae61b_5cfa_4324_ad65_5fa2f7338262
constant: false
is encoded by: hsa:6568
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC17A1
boundary condition: true
type: Species
has only substance units: false
is: Q14916

metaR r0998
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
name: Facilitated diffusion
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000

metaR CLOXAtex2
modifier: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: chloride transport via oxalate countertransport (2:1)
product: MODEL1310110017#
is described by: ECO:0000304
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_f6ee57cd_eb36_4a5f_bf14_740fb6b06c4a
constant: false
has only substance units: false
is: P49189
type: Species
boundary condition: true
name: ALDH9A1
is encoded by: hsa:223
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DHFtm
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
name: dihydrofolate reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true

metaM gua c
initial amount: NaN
is: C00242
is: CHEBI:16235
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
constant: false
name: Guanine
is: HMDB00132
initial concentration: 1.0
boundary condition: false

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

metaM coa r
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
name: Coenzyme A
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01423
initial amount: NaN
is: C00010
initial concentration: 1.0
has only substance units: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110017#_accc8260_ef09_4f90_bbf5_c9bc762a9cec
initial concentration: NaN
constant: false
is encoded by: hsa:5315
type: Species
boundary condition: true
initial amount: NaN
is: P14618
name: PKM2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_653eb927_4ac6_46c3_a07c_c867f29978f0
has only substance units: false
is encoded by: hsa:501
initial concentration: NaN
name: ALDH7A1
is: SBO:0000252
is: E7EPT3
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR 34DHXMANDACOX NADP
is: SBO:0000176
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: O2 nuclear transport
is: SBO:0000185

metaM acetone e
boundary condition: false
is: HMDB01659
type: Species
has only substance units: false
name: acetone
is: CHEBI:15347
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
initial amount: NaN

metaM HC01162 c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
boundary condition: false
initial concentration: 1.0
is: CHEBI:58376
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
has only substance units: false
constant: false
type: Species

metaM i e
is: SBO:0000247
constant: false
type: Species
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial concentration: 1.0
is: HMDB12238
has only substance units: false
boundary condition: false
initial amount: NaN

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110017#
reversible: false
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_63e57698_5f2c_4758_ac7f_93389e26c719
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI601100
has only substance units: false
name: _AI601100_1_m
initial concentration: NaN
initial amount: NaN

metaR ICDHyrm
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110017#
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_bb29f089_ee2a_4352_b6f3_dc241403a495
name: ACP5
initial concentration: NaN
is encoded by: hsa:54
has only substance units: false
initial amount: NaN
is: P13686
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ccfdb8d5_cd83_4046_9bb8_7e7040c7e16e
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:26289
initial concentration: NaN
name: AK5
constant: false
is: Q9Y6K8
is: SBO:0000252

metaM pmtcrn x
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17490
name: L-palmitoylcarnitine
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f547a0fa_1897_4b42_b9a7_d04ae8d31377
constant: false
has only substance units: false
initial amount: NaN
name: PLD1
initial concentration: NaN
is encoded by: hsa:5337
type: Species
is: Q59EA4
boundary condition: true
is: SBO:0000252

metaM retinal cis 13 r
is: HMDB06220
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
is: CHEBI:45487
constant: false

metaM 2oxoadp m
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
boundary condition: false
is: CHEBI:57499
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: 2-oxoadipate(2-)

metaM pi r
is: CHEBI:43474
has only substance units: false
initial amount: NaN
name: hydrogenphosphate
is: C00009
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial concentration: 1.0
is: HMDB00973
constant: false
is: SBO:0000247

metaR O2tm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reactant: MODEL1310110017#
name: O2 transport (diffusion)
product: MODEL1310110017#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaR r0360
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM ump n
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
has only substance units: false
is: CHEBI:57865
initial concentration: 1.0
is: HMDB00288
constant: false

metaR ACALDt
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
name: acetaldehyde reversible transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110017#

metaR UGALNACtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110017#
name: UDP-GalNAc Golgi transport via CMP antiport

metaM gua e
boundary condition: false
is: SBO:0000247
is: CHEBI:16235
name: guanine
is: HMDB00132
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

metaR SPMTDe
name: SPMTDe
reversible: true
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#

metaR DSAT
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: false
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000176
fast: false
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110017#

metaR ASCBOX
is described by: ECO:0000000
name: ascorbic acid oxidase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR r2098
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000

metaR r0915
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185

metaR DURIPP
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
is described by: ECO:0000269
name: deoxyuridine phosphorylase
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
fast: false

metaR FADH2ETC
fast: false
name: Complex II reaction for respiratory chain
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
reversible: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110017#_a7f793a7_f0fa_4dff_a211_92d30d24dc0d
boundary condition: true
type: Species
name: SLC5A8
constant: false
initial amount: NaN
is: Q8N695
is encoded by: hsa:160728
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_fe966a96_9011_4c57_95fa_560c31eec172
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110017#_cd28a178_56a5_4c73_99fd_aa5cfbe48d4e
is: Q8N3T1
boundary condition: true
is encoded by: hsa:117248
constant: false
name: GALNTL2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR r0295
kinetic law: MODEL1310110017#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#

metaR r1602
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM amet c
constant: false
is: C00019
initial concentration: 1.0
is: CHEBI:15414
is: HMDB01185
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
name: S-Adenosyl-L-methionine
is: SBO:0000247

metaM crn c
is: SBO:0000247
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: CHEBI:16347
initial concentration: 1.0
has only substance units: false
is: HMDB00062
initial amount: NaN
name: L-Carnitine
is: C00318
constant: false

metaM arachd l
name: arachidonate
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01043
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM ru5p D c
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58121
boundary condition: false
name: D-ribulose 5-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110017#_7d15a770_aaa2_4ae1_910f_7502ba5ff3b6
has only substance units: false
type: Species
is: P56556
name: NDUFA6
is: SBO:0000252
is encoded by: hsa:4700
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR r2380
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110017#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_4d86d97f_f6d5_4ea0_8082_d8efeb83d6ed
boundary condition: true
has only substance units: false
name: GALNT6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11226
type: Species
constant: false
is: Q8NCL4

metaR r2099
is: SBO:0000185
fast: false
modifier: MODEL1310110017#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000

metaM thp2c x
has only substance units: false
constant: false
is: CHEBI:16987
type: Species
name: 1-piperideine-6-carboxylate
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
is: SBO:0000247
is: HMDB12130

metaM HC02214 e
is: SBO:0000247
has only substance units: false
constant: false
name: prostaglandin-f1alpha
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852

http://identifiers.org/biomodels.db/MODEL1310110017#_b6335fc8_29b0_4994_ac72_3345ef954f01
name: ACSS1
type: Species
is encoded by: hsa:84532
boundary condition: true
is: SBO:0000252
is: Q9NUB1
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM hxan c
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: Hypoxanthine
is: HMDB00157
has only substance units: false
type: Species
is: C00262
initial amount: NaN
is: CHEBI:17368
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_db7ba47e_f0fd_4b06_b0d2_5a57e77fc278
is encoded by: hsa:28232
boundary condition: true
is: Q9UIG8
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLCO3A1
has only substance units: false
constant: false

metaM acgam r
boundary condition: false
is: HMDB00215
type: Species
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
name: N-acetyl-D-glucosamine
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM 1pyr5c m
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false
is: HMDB01301
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: 1-Pyrroline-5-carboxylate
is: C03912
initial concentration: 1.0
is: SBO:0000247

metaR RE1531M
modifier: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1531
product: MODEL1310110017#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR r1680
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_8aaeeb8e_6908_4a29_a2f2_3161b974b89e
name: GALE
is: SBO:0000252
is: Q38G75
initial amount: NaN
is encoded by: hsa:2582
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false

metaR r0797
modifier: MODEL1310110017#
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_bcfaeada_6ee6_4971_ad2d_92e93ba392b8
is: O00217
boundary condition: true
name: NDUFS8
has only substance units: false
initial amount: NaN
is encoded by: hsa:4728
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1603
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
type: Reaction

metaM pchol hs e
initial amount: NaN
constant: false
has only substance units: false
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16110
type: Species
boundary condition: false
initial concentration: 1.0

metaR PTPATe
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
name: PTPATe
is described by: ECO:0000134
reactant: MODEL1310110017#
is: SBO:0000176

metaR CHOLtn
name: Choline transport, nuclear through pores
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110017#

metaR NODe
fast: false
reactant: MODEL1310110017#
name: NODe
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000134
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_e37ef786_2684_4e14_a016_ac645c93bd67
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6IB80
is encoded by: hsa:4709
has only substance units: false
is: SBO:0000252
name: NDUFB3

metaR r0917
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR GMPR
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
is version of: http://identifiers.org/ec-code/1.7.1.7
is described by: ECO:0000269
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
name: GMP reductase
reversible: false
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a24a032d_b472_4d7a_aa17_06ee40462ffe
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:11112
boundary condition: true
has only substance units: false
name: HIBADH
initial amount: NaN
constant: false
is: P31937

http://identifiers.org/biomodels.db/MODEL1310110017#_179d6ef0_b883_40f2_bf7c_faf181b74257
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM tre e
name: Trehalose
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16551
initial concentration: 1.0
type: Species
is: C01083
has only substance units: false

metaR r0651
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR CHAT
fast: false
reversible: true
type: Reaction
name: Choline O-acetyltransferase
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
kinetic law: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110017#
reactant: MODEL1310110017#

metaR r1600
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM gum e
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
type: Species
name: gums
has only substance units: false
is: HMDB00725
initial concentration: 1.0

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_ea376f9c_92b2_4944_bb29_553c424801f0
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _AU149534_1_m
initial concentration: NaN
is encoded by: hsa:AU149534

metaR P5CRxm
fast: false
reversible: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
reactant: MODEL1310110017#
name: pyrroline-5-carboxylate reductase (m)
is: SBO:0000176
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110017#_8b49206c_2b2a_44b0_8532_aca568a371e4
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: PCBD1
is encoded by: hsa:5092
is: P61457
initial concentration: NaN
has only substance units: false

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000254
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reversible: true
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_20a5a402_62e4_48b1_b32e_722135ca0a77
is encoded by: hsa:BE966236
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: _BE966236_1_m
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_af0f4699_14d7_4b37_90f3_e29609052e34
type: Species
is: E2QC23
is encoded by: hsa:23464
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GCAT

metaM ppcoa c
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
boundary condition: false
is: CHEBI:57392
initial amount: NaN
has only substance units: false
name: Propanoyl-CoA
is: SBO:0000247
type: Species
constant: false
is: HMDB01275

metaR r0650
reactant: MODEL1310110017#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e8a8bb95_476d_4813_8f5a_c07ef92305a6
name: SLC6A2
is: SBO:0000252
has only substance units: false
constant: false
is: Q96KH8
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6530
boundary condition: true

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM pchol hs g
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
is: CHEBI:16110
has only substance units: false
name: Phosphatidylcholine
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_2205d047_ee1d_412d_9b36_4f1bc95c56d4
initial concentration: NaN
name: ALDH1A1
is: P00352
initial amount: NaN
is encoded by: hsa:216
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaM nadph r
is: HMDB00221
initial concentration: 1.0
is: CHEBI:57783
type: Species
is: C00005
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_5e8857bd_7555_48cb_8378_0e0375935f9a
has only substance units: false
name: _AU149534_1_c
boundary condition: true
constant: false
is encoded by: hsa:AU149534
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GTHPm
product: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is: SBO:0000176
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110017#
name: glutathione peroxidase, mitochondria
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true

metaR ILEt4
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
name: L-isoleucine transport in via sodium symport
reactant: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000304

metaR r1606
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM glyc3p c
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
is: C00093
is: HMDB00126
name: Glycerol 3-phosphate
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaM prpp e
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58017
boundary condition: false

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16769
initial amount: NaN
name: 2-oxoglutaramate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_30488d34_1f25_40d3_b45f_caecbaaefa32
is: Q9NRA2
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26503
boundary condition: true
constant: false
name: SLC17A5
is: SBO:0000252

metaM glx x
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial concentration: 1.0
is: HMDB00119
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR RDH3
fast: false
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
modifier: MODEL1310110017#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110017#
name: retinol dehydrogenase (11-cis,NADH)
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_0a9c273f_9598_4dab_8ec8_0dc67d8de089
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: FOLR1

metaM pectindchac e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2559H3549O2539 CHARGE: -1
name: pectin-deoxycholic acid complex
constant: false
is: HMDB03402
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f521a515_a049_4247_9a43_1e14bb1f74ff
initial concentration: NaN
initial amount: NaN
name: _M68895_1_c
has only substance units: false
is encoded by: hsa:M68895
constant: false
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_cc6c45a2_1962_472e_9b8e_5d627dc5a683
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI971036
constant: false
is: SBO:0000252
type: Species
name: _AI971036_1_m
initial concentration: NaN
boundary condition: true

metaR DHPM1
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
product: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.5.2.2
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110017#
name: dihydropyrimidinase (5,6-dihydrouracil)
reversible: false

metaR r1607
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_d6e84f49_1660_4106_b4ba_beb04fa88451
name: RRM1:RRM2
has part: P23921
constant: false
initial concentration: NaN
initial amount: NaN
has part: P31350
boundary condition: true
is encoded by: hsa:6240
has only substance units: false
is encoded by: hsa:6241
type: Species
is: SBO:0000297

metaM glcur e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: CHEBI:15748
is: HMDB00127
boundary condition: false

metaM dudp m
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01000
has only substance units: false
is: CHEBI:60471
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
constant: false
name: dUDP(3-)

metaR DPCOAtl
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
name: dephospho-CoA transport from lysosome via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
fast: false
kinetic law: MODEL1310110017#

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR RE1527M
product: MODEL1310110017#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110017#
is: SBO:0000176
name: RE1527
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f34d3117_ca82_4cf1_b239_82a0beed89b3
is: SBO:0000252
constant: false
is encoded by: hsa:4952
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: OCRL

metaR LTC4CP
is: SBO:0000176
reversible: true
name: Leukotriene C4 carboxypeptidase
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM acgam6p c
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57513
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01062
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357

metaR NTD6
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
type: Reaction
product: MODEL1310110017#
name: 5'-nucleotidase (dAMP)
is: SBO:0000176
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134

metaM co2 x
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01967
has only substance units: false
name: carbon dioxide
boundary condition: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
initial amount: NaN

metaR r1604
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
type: Reaction

metaM chol n
name: choline
has only substance units: false
is: SBO:0000247
is: CHEBI:15354
is: HMDB00097
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110017#_986dd335_0613_4156_a3bf_d48ad5a9787e
name: MECR
constant: false
is: SBO:0000252
is encoded by: hsa:51102
boundary condition: true
is: Q9BV79
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaM 2obut c
is: HMDB00005
initial amount: NaN
is: CHEBI:16763
name: 2-Oxobutanoate
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial concentration: 1.0
is: C00109

metaR r0655
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
reactant: MODEL1310110017#
is described by: ECO:0000000

metaM hdca c
is: CHEBI:7896
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: palmitate
initial concentration: 1.0
is: HMDB00220
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
constant: false

metaR r0321
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction

metaR r0796
product: MODEL1310110017#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_a09165cf_9ec5_4ba4_b9d8_aeecaf782485
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2954
name: GSTZ1
type: Species
is: A6NED0
initial amount: NaN
constant: false

metaM glu5sa c
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: HMDB02104
initial amount: NaN
is: SBO:0000247
name: L-Glutamate 5-semialdehyde
type: Species
is: C01165
is: CHEBI:17232
constant: false
boundary condition: false
initial concentration: 1.0

metaM ksii core2 deg8 l
constant: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 8
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110017#_44409486_cdf5_4e4b_9946_dc4e0e2bcc3e
is: SBO:0000252
name: SUCLA2
is: E5KS60
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:8803
initial concentration: NaN
initial amount: NaN

metaM acgam l
is: SBO:0000247
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
has only substance units: false
is: CHEBI:17411
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00215

metaR r1605
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_438bc368_d96a_4a7f_9ae9_64b7edb4c420
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ACSL5
is: Q9ULC5
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:51703

metaR r2382
reversible: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000000

metaM fum m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
is: C00122
name: Fumarate

http://identifiers.org/biomodels.db/MODEL1310110017#_8af055e3_83d0_4d27_a1f8_6f9b36872fc1
boundary condition: true
name: LDHD
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:197257
initial concentration: NaN

metaR KSII CORE4tly
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
reversible: false
is described by: ECO:0000000
name: keratan sulfate II (core 4) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#

metaM chol m
type: Species
name: choline
initial amount: NaN
is: CHEBI:15354
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a0d3aee7_9397_4ccb_b09b_973b0cf9bf42
is encoded by: hsa:8608
name: RDH16
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: O75452
is: SBO:0000252
type: Species
has only substance units: false

metaR G6PDA
product: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.99.6
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
name: glucosamine-6-phosphate deaminase

metaM udpg c
is: C00029
is: HMDB00286
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: SBO:0000247
name: UDPglucose
type: Species
is: CHEBI:58367
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_3388a96c_9bc1_46c1_92e8_4a0de8f5cbda
type: Species
constant: false
name: _U52111_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:U52111
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_683aa5d7_e3d2_4671_a4be_6c33663d1f02
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O95674
name: CDS2
is: SBO:0000252
is encoded by: hsa:8760
has only substance units: false
type: Species

metaR r0853
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
reversible: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM bhb c
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:10983
is: HMDB00011
name: (R)-3-hydroxybutyrate
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_f947908d_6d3f_4501_811a_65fcfc2e1aa9
is encoded by: hsa:6389
is encoded by: hsa:6392
constant: false
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
has part: Q99643
boundary condition: true
has part: P31040
is encoded by: hsa:6390
type: Species
has part: O14521
initial amount: NaN
has part: P21912
is encoded by: hsa:6391
has only substance units: false
is: SBO:0000297

metaR r1576
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR CHSTEROLt2
reactant: MODEL1310110017#
name: cholesterol intracellular transport
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_a6d1cfd7_680a_48a0_aa06_ac4c8db9b4ba
is: SBO:0000252
type: Species
constant: false
name: _AI824319_1_r
has only substance units: false
is encoded by: hsa:AI824319
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_501ad866_409a_4085_88d0_93906eefb37e
initial concentration: NaN
is encoded by: hsa:35
has only substance units: false
name: ACADS
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: P16219
initial amount: NaN

metaR r2387
reactant: MODEL1310110017#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110017#
modifier: MODEL1310110017#

metaM co2 r
boundary condition: false
type: Species
is: HMDB01967
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
is: CHEBI:16526
is: C00011
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaR PA HStg
fast: false
is described by: ECO:0000000
type: Reaction
name: phosphatidate scramblase
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_69930716_63a2_4567_9552_94061e341e6e
is: Q8N0X4
initial amount: NaN
is encoded by: hsa:171425
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: CLYBL
constant: false

metaM arachd c
is: CHEBI:32395
initial concentration: 1.0
type: Species
is: HMDB01043
has only substance units: false
name: arachidonate
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110017#_5a578067_4696_40cf_9c8d_9f87b39a2962
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7498
type: Species
name: XDH
initial concentration: NaN
boundary condition: true
is: P47989

metaM 1pyr5c c
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: 1-Pyrroline-5-carboxylate
constant: false
is: HMDB01301
is: C03912
is: CHEBI:15893
boundary condition: false

metaR TALA
name: transaldolase
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.2
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_dbe56d4a_b7cc_421c_ab54_b1c707a5829a
constant: false
is: Q1LZ56
is encoded by: hsa:206358
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: SLC36A1

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: HMDB01163
initial concentration: 1.0

metaM udpg e
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367
initial concentration: 1.0
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4b7553b9_8ddc_413d_b1f6_ec91b595dbd1
constant: false
is: Q9UPY5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23657
has only substance units: false
type: Species
name: SLC7A11

metaM HC01603 c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57454
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
is: SBO:0000247

metaR Ser Thrtg
reactant: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110017#
is described by: ECO:0000269
fast: false
reversible: true
name: Ser/Thr transport (from golgi to lysosome)

metaR r1575
fast: false
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_232aaac6_a1eb_4956_9815_a88813c6e4ae
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6649
is: P08294
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SOD3

metaR CHSTEROLt1
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
name: cholesterol intracellular transport
fast: false
modifier: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_4c05cf26_dce2_44c7_8a55_0025547f3e46
initial concentration: NaN
has only substance units: false
is: Q8TDQ7
boundary condition: true
name: GNPDA2
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:132789

metaM pail45p hs c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaM HC01104 e
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:61146
boundary condition: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00221
is: SBO:0000247
is: C00005
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_f9dbef76_76e7_4d7e_be8d_33eb99737a86
has only substance units: false
name: FPGS
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2356
is: Q05932

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
fast: false
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#

metaR ACACt2
product: MODEL1310110017#
name: acetoacetate transport via proton symport
modifier: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
reversible: true

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM glu L l
is: HMDB00148
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
initial amount: NaN
initial concentration: 1.0

metaR PMTCOAtx
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR HAtly
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: hyaluronan transport, extracellular to lysosome
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM spc hs e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
constant: false
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

metaR P5CR
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110017#
name: pyrroline-5-carboxylate reductase
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_945618aa_24d7_4f59_9cdf_a5792901a2b6
name: _T83654_1_c
initial concentration: NaN
type: Species
is encoded by: hsa:T83654
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaR r1578
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction

metaM retinal c
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15035
name: retinal
is: HMDB01358
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0

metaR r1608
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
fast: false

metaR Htg
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110017#
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_9ad1689e_8e6a_4135_82c9_027a05a450da
is: P35219
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CA8
constant: false
is encoded by: hsa:767

metaM oh1 e
name: hydroxide ion
constant: false
notes: FORMULA: HO CHARGE: -1
boundary condition: false
initial amount: NaN
is: HMDB01039
is: C01328
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR r2385
reversible: false
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185

metaR DCYTDn
reversible: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
name: deoxycytidine deaminase, nuclear
is version of: http://identifiers.org/ec-code/3.5.4.5

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR GULNDer
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
reversible: true
name: gulonate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction

metaM glu L m
is: SBO:0000247
initial concentration: 1.0
is: HMDB00148
boundary condition: false
name: L-glutamate(1-)
initial amount: NaN
is: CHEBI:29985
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
fast: false
type: Reaction
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR r0791
is: SBO:0000176
is described by: ECO:0000000
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_0316b825_bd58_4b28_a20f_0bc0f836d395
is encoded by: hsa:11181
initial amount: NaN
is: O43280
type: Species
has only substance units: false
initial concentration: NaN
name: TREH
is: SBO:0000252
constant: false
boundary condition: true

metaM glcur c
name: D-glucuronate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00127
is: CHEBI:15748

metaR SERtN1
reversible: true
modifier: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: Serine transport (Na, H coupled)

metaR RE3524R
is: SBO:0000176
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
name: RE3524
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
fast: false

metaR r2386
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_8be115c6_fc12_46ac_b747_a6d13ae6b386
is encoded by: hsa:54511
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: HMGCLL1
is: Q9NT06

metaR r1609
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#

metaR CHOLtu
fast: false
name: Choline uniport
reactant: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000269
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_1a86c67e_fda0_4d13_bb39_6131267556d3
constant: false
is: SBO:0000252
is: D3DX95
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
type: Species
name: CHAT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_53505aed_1a7f_4f5c_85d9_685d27def7e1
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:23057
initial concentration: NaN
name: NMNAT2
is: SBO:0000252
has only substance units: false

metaM 5adtststerones c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

http://identifiers.org/biomodels.db/MODEL1310110017#_0e3d24f6_84ad_4407_b7db_70ca7f654d8f
initial amount: NaN
is: SBO:0000252
name: TKTL1
is encoded by: hsa:8277
constant: false
initial concentration: NaN
has only substance units: false
is: B7Z7I0
boundary condition: true
type: Species

metaM spc hs c
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: sphingosylphosphorylcholine
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

metaR CRMPte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
name: crmp hs transport
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM cmp n
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: SBO:0000247
is: HMDB00095
is: CHEBI:60377
constant: false
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_ba399140_8c3a_45dc_a884_95dfccaf7f14
is: SBO:0000252
is: Q4FEB3
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1215
name: CMA1

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01039
is: C01328
name: hydroxide ion
is: SBO:0000247
boundary condition: false

metaM man6p c
is: HMDB01078
name: D-Mannose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17369
boundary condition: false
has only substance units: false

metaR r1571
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
type: Reaction

metaR r0437
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110017#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_830073f9_44b8_4311_bc97_c5f861177319
boundary condition: true
is encoded by: hsa:9187
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: B4DUG1
name: SLC24A1

http://identifiers.org/biomodels.db/MODEL1310110017#_a9e607a0_ee8c_4133_aa7e_c785baf51754
name: SLC9A1
constant: false
is: SBO:0000252
is: P19634
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:6548
initial amount: NaN
initial concentration: NaN

metaM lac L x
has only substance units: false
constant: false
boundary condition: false
name: (S)-lactate
is: HMDB00190
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651

metaM ddcacoa m
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
is: C01832
is: HMDB03571
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species

metaM dadp c
is: HMDB01508
is: CHEBI:57667
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dADP
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: C00206
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR CYTK14n
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM ppcoa m
is: SBO:0000247
is: HMDB01275
type: Species
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00100
boundary condition: false
name: Propanoyl-CoA
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110017#_22adeb92_ebea_46b6_abfd_292fee30fc6e
is: SBO:0000252
type: Species
name: _AA081045_1_e
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110017#_aa5cf420_4d43_47d7_8009_9d57f2cc989e
initial concentration: NaN
name: _100128062_1_m
is encoded by: hsa:100128062
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR HSD11B2r
is: SBO:0000176
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.146
name: 11-beta-hydroxysteroid dehydrogenase type 2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
reversible: true
modifier: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM 2obut m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: SBO:0000247
is: HMDB00005
name: 2-oxobutanoate
initial concentration: 1.0
constant: false
is: CHEBI:16763
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaM gthox m
is: CHEBI:58297
is: HMDB03337
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR NACHEX25ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
reversible: false
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110017#

metaR r1574
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110017#
type: Reaction

metaM 5adtststerones e
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
boundary condition: false
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaR OCDCAtr
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185

metaM bhb e
initial concentration: 1.0
is: HMDB00011
is: SBO:0000247
is: CHEBI:10983
constant: false
name: (R)-3-hydroxybutyrate
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
initial amount: NaN
boundary condition: false

metaR r0434
kinetic law: MODEL1310110017#
reversible: true
modifier: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110017#_b1d3e3f5_d928_4614_809b_cbe818aa2890
initial concentration: NaN
name: DLAT
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1737
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q86YI5

http://identifiers.org/biomodels.db/MODEL1310110017#_d59aa5d7_3caa_419f_9bf2_ffab8e8f23ae
type: Species
initial amount: NaN
is encoded by: hsa:7355
initial concentration: NaN
constant: false
is: SBO:0000252
is: P78381
has only substance units: false
boundary condition: true
name: SLC35A2

http://identifiers.org/biomodels.db/MODEL1310110017#_7aac219c_3a9b_4538_9603_66d1ea23571b
is encoded by: hsa:6575
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: SLC20A2
is: B2RBR4
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r2389
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaM arachd e
type: Species
is: HMDB01043
constant: false
name: arachidonate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9dc902d3_9f5e_4f6a_afba_1b37ff50795c
has only substance units: false
is encoded by: hsa:5167
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P22413
name: ENPP1
constant: false
initial concentration: NaN

metaR GGH 7DHFe
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_eedecd8d_6f36_4506_baf8_3507178b90f8
name: ACOX1
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:51
is: B4DK61
initial concentration: NaN
boundary condition: true

metaR ACACt2m
product: MODEL1310110017#
name: Acetoacetate mitochondrial transport via H+ symport
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD

metaR ALCD2yf
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110017#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM pchol hs c
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: Phosphatidylcholine
is: CHEBI:16110
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_35a85215_be84_4900_b631_617e2abbcbbc
is encoded by: hsa:1809
is: SBO:0000252
is: Q8IXW6
has only substance units: false
initial amount: NaN
boundary condition: true
name: DPYSL3
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_684a75f9_7c81_4bce_b212_08c1544eba76
is: Q96RV2
constant: false
initial concentration: NaN
name: HAS3
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3038
initial amount: NaN
boundary condition: true

metaR THP2Ctp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
kinetic law: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_d4437eaf_e088_4f2b_a4cc_92371e52a8cc
is: P10696
name: ALPPL2
is encoded by: hsa:251
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR CHSTEROLt3
is described by: ECO:0000000
name: cholesterol intracellular transport
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r1573
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM hxan e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
type: Species
is: HMDB00157
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17368
name: hypoxanthine

metaR r0541
reversible: true
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_5750b6b6_9aed_4a5c_8136_8ca7491c0ac4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AV713053
constant: false
type: Species
name: _AV713053_1_m
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC02214 c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
is: CHEBI:28852
boundary condition: false
constant: false

metaM hpyr c
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxypyruvate
is: HMDB01352
is: CHEBI:17180
initial amount: NaN
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
constant: false

metaM CE4876 r
boundary condition: false
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00127
is: SBO:0000247
type: Species

metaR URIt5le
name: uridine transport in via sodium symport (1:2)
fast: false
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110017#

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: reverse-triiodthyronine
type: Species
is: CHEBI:28774

http://identifiers.org/biomodels.db/MODEL1310110017#_89a36d99_ea04_4405_84a2_6c165f6e5356
is: SBO:0000252
has only substance units: false
is encoded by: hsa:622
initial amount: NaN
type: Species
name: BDH1
boundary condition: true
initial concentration: NaN
constant: false

metaR PPD2CSPp
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: PPD2CSPp
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110017#

metaM trdrd c
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: C00342
initial concentration: 1.0
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin

metaR r1936
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false

metaR HIBDm
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110017#
fast: false
reversible: true
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_72fc8e03_530e_408b_81b6_4e7b37634538
constant: false
is: B4DUY1
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:10948
name: STARD3
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_71558621_3f0c_4f21_84dd_5ab92090ecd1
type: Species
name: SLC24A3
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9HC58
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57419

http://identifiers.org/biomodels.db/MODEL1310110017#_5afaa696_5cf5_4828_879a_631cc7d340f9
type: Species
name: SLC27A1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:376497

http://identifiers.org/biomodels.db/MODEL1310110017#_ffb6e7a7_e5af_4327_b6b2_28a07456192a
name: PKLR
is: P30613
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5313
type: Species
has only substance units: false
constant: false

metaR RE1901R
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
reactant: MODEL1310110017#
name: RE1901
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ff168e71_39e6_4571_891e_3351c6269e46
constant: false
name: GMPR2
is: Q9P2T1
initial concentration: NaN
type: Species
is encoded by: hsa:51292
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM r1p c
is: CHEBI:57720
type: Species
name: alpha-D-Ribose 1-phosphate
is: C00442
constant: false
is: HMDB01489
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9e587e65_12f9_4288_8559_5e198aaf9d58
name: NDUFB8
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: O95169
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4714

http://identifiers.org/biomodels.db/MODEL1310110017#_81636df0_d04e_448c_9b7f_2abadd3c38c7
has only substance units: false
is: SBO:0000252
constant: false
name: _AA977580_1_c
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AA977580
boundary condition: true

metaM acgam c
is: HMDB00215
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: N-acetyl-D-glucosamine
initial amount: NaN
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
boundary condition: false
is: CHEBI:17411

metaM etoh e
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
name: ethanol
is: CHEBI:16236
boundary condition: false
is: SBO:0000247
is: HMDB00108

metaM glx m
constant: false
type: Species
is: HMDB00119
boundary condition: false
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: glyoxylate

metaM HC00342 c
initial concentration: 1.0
is: CHEBI:16383
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
boundary condition: false
name: cis-aconitate(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_41329232_35f6_4ed0_b19a_0771d91a88f8
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P18283
has only substance units: false
is: SBO:0000252
name: GPX2
constant: false
type: Species
is encoded by: hsa:2877

metaR KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
name: KHte
kinetic law: MODEL1310110017#
is described by: ECO:0000134

metaR RE1898C
name: RE1898
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_b860be34_d558_4eb8_8fdd_d9c0055852a1
initial concentration: NaN
initial amount: NaN
name: GGT2
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:728441

metaM xmp c
name: Xanthosine 5'-phosphate
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB01554
is: C00655
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: SBO:0000247
is: CHEBI:57464

metaR r1580
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false

metaM glyc3p x
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Glycerol 3-phosphate
is: HMDB00126
is: CHEBI:57597
constant: false
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: C00093
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_32088841_3820_4834_b6f1_400b44c8ddf1
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: _728637_1_c
is encoded by: hsa:728637

metaM sphs1p c
is: HMDB00277
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
type: Species
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_10d0670c_550a_4e9c_b642_3a439a4aa4cf
is: SBO:0000252
boundary condition: true
is: Q9UBX3
is encoded by: hsa:1468
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC25A10

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR ACt2r
reactant: MODEL1310110017#
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: acetate reversible transport via proton symport

metaR RTOTAL3t
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL3 transport
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM ppa c
initial amount: NaN
type: Species
initial concentration: 1.0
name: propionate
constant: false
is: CHEBI:17272
is: HMDB00237
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: SBO:0000247

metaR MALSO3tm
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110017#_5764fa5c_c8a7_406a_a0ad_ab756644e47e
name: CHKB
boundary condition: true
is: A0PJM6
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1120
has only substance units: false
constant: false

metaM CE2418 m
has only substance units: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB11123
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
boundary condition: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110017#_105003d6_912c_4834_969f_e79a81ad149f
has only substance units: false
constant: false
is encoded by: hsa:4725
initial amount: NaN
name: NDUFS5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q6IBA0
type: Species

metaM damp c
type: Species
constant: false
is: HMDB00905
initial amount: NaN
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58245
boundary condition: false
has only substance units: false
name: dAMP(2-)

metaR r1581
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaM e4hglu m
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
constant: false
is: CHEBI:6331
type: Species
initial concentration: 1.0
is: HMDB02273

http://identifiers.org/biomodels.db/MODEL1310110017#_510c7b94_d569_441e_b481_a78e1dba94ff
constant: false
is encoded by: hsa:23475
is: Q15274
name: QPRT
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r0226
is described by: ECO:0000000
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
is: SBO:0000176
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false
type: Reaction

metaR r1782
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000185

metaR r0178
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
type: Reaction
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110017#
reversible: true
fast: false

metaM glu L e
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:29985
initial concentration: 1.0
name: L-glutamate(1-)
is: HMDB00148
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0113
reversible: false
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110017#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_80e1da51_c3e0_4267_8783_2f92c0eb1895
constant: false
type: Species
name: ALOX5
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P09917
is encoded by: hsa:240

metaR 3HBCOAHLm
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
kinetic law: MODEL1310110017#
reversible: false
type: Reaction

metaM etoh c
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: ethanol
is: SBO:0000247
is: CHEBI:16236
is: HMDB00108
constant: false
type: Species

metaM pail45p hs n
is: CHEBI:28910
type: Species
constant: false
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
initial amount: NaN

metaM pglyc hs c
boundary condition: false
has only substance units: false
name: phosphatidylglycerol(1-)
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: CHEBI:60523
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_9e5337ed_218f_4e61_96de_8884ddd8ee91
name: PTS
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5805
is: Q03393
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM sphs1p e
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
initial amount: NaN
constant: false
is: HMDB00277
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f188dc3e_b498_48a0_b52c_d044ec1a521c
initial amount: NaN
is: P49189
boundary condition: true
is encoded by: hsa:223
type: Species
name: ALDH9A1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_cafce7e8_c32f_4dc6_92c8_cf94e714187f
is: P00568
name: AK1
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:203

metaR TRPt
modifier: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
fast: false
name: L-tryptophan transport
type: Reaction

metaR MAN6PI
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110017#
name: mannose-6-phosphate isomerase
is described by: ECO:0000304
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_7e47966a_3997_491c_9ed1_6c6a4bf0ab74
name: G6PC2
constant: false
is: SBO:0000252
is encoded by: hsa:57818
initial amount: NaN
is: E9PAX2
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaR HDCAter
kinetic law: MODEL1310110017#
name: palmitate ER export
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reversible: false

metaR PETOHMr hs
is described by: ECO:0000254
name: phosphatidylethanolamine N-methyltransferase
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.1.1.17
reversible: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
is: SBO:0000176
fast: false
product: MODEL1310110017#

metaM xylu L c
is: SBO:0000247
constant: false
name: L-xylulose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
is: HMDB00751
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17399
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_d1ed8238_2ca4_42b1_ba4e_63cd1ee43478
boundary condition: true
initial concentration: NaN
has part: Q9UHI5
initial amount: NaN
constant: false
name: SLC7A8:SLC3A2
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:23428

metaR COAtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
type: Reaction
name: CoA transport in lysosome via diffusion
product: MODEL1310110017#

metaR CYTK6n
kinetic law: MODEL1310110017#
type: Reaction
name: cytidylate kinase (CMP,CTP),nuclear
product: MODEL1310110017#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaR TDCHOLAte
kinetic law: MODEL1310110017#
fast: false
name: bile acid intracellular transport
reversible: true
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_21cbd713_a71a_429b_8027_9907c83a0c07
is encoded by: hsa:5538
is: Q6FGQ4
boundary condition: true
name: PPT1
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_3cf33719_90e9_4106_b409_5e315f441d2c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: GMPPA
constant: false
boundary condition: true
is encoded by: hsa:29926
is: SBO:0000252

metaR r1780
reactant: MODEL1310110017#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false

metaR r0399
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1

metaR r0547
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR VALTAm
name: valine transaminase, mitochondiral
kinetic law: MODEL1310110017#
fast: false
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR r2443
reactant: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR ECOAH1m
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.18
reactant: MODEL1310110017#
is described by: ECO:0000304
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_5fb2c4f4_0eee_4642_bd19_c99587259cda
type: Species
constant: false
name: COX5A
is encoded by: hsa:9377
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P20674
boundary condition: true

metaR COAtm
name: CoA transporter
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_bba81d11_837b_4172_8d17_ffab423b98b6
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:50484
name: RRM2B
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q7LG56

metaM val L e
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
boundary condition: false
is: CHEBI:16414
initial amount: NaN
type: Species
is: HMDB00883
is: SBO:0000247
name: L-valine
initial concentration: 1.0

metaR EX progly LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for prolyl-glycine
type: Reaction

metaM tchola e
is: SBO:0000247
is: HMDB00036
type: Species
name: taurocholic acid
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN

metaR GTHRDt
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
name: Glutathione transport into mitochondria
fast: false
is described by: ECO:0000000

metaR r0549
fast: false
is version of: http://identifiers.org/ec-code/6.1.1.17
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
modifier: MODEL1310110017#

metaM amet r
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
name: S-adenosyl-L-methionine
type: Species
is: SBO:0000247
is: CHEBI:15414
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaR URIt
reactant: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
product: MODEL1310110017#
fast: false
name: uridine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110017#
is: SBO:0000185

metaM e4p c
constant: false
is: CHEBI:16897
is: SBO:0000247
name: D-Erythrose 4-phosphate
initial concentration: 1.0
is: HMDB01321
type: Species
is: C00279
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
boundary condition: false
has only substance units: false

metaM HC02203 c
is: SBO:0000247
name: prostaglandin-a2
has only substance units: false
is: CHEBI:27820
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

metaM hdca r
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: HMDB00220
is: C00249
boundary condition: false
constant: false
is: CHEBI:7896
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR COAtn
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: coenzyme A transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_c1e3be90_3718_4b9d_839d_26913f36fa18
has only substance units: false
is: Q9Y2D0
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11238
name: CA5B
type: Species
constant: false

metaR PECDCHe
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM ksii core4 deg1 l
is: HMDB00868
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
constant: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 1
type: Species
has only substance units: false

metaM h2o2 e
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
has only substance units: false
type: Species
name: hydrogen peroxide
is: CHEBI:16240
is: SBO:0000247
is: HMDB03125

metaR ITCOALm
fast: false
type: Reaction
is described by: ECO:0000212
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR ANTHte
fast: false
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110017#
name: Transport of anthranilate

metaM ru5p D r
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
is: SBO:0000247
is: CHEBI:58121
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

http://identifiers.org/biomodels.db/MODEL1310110017#_8d83e8ea_a635_4a87_89d8_2f1e7c01149c
boundary condition: true
has only substance units: false
is: E7EPT3
initial concentration: NaN
name: ALDH7A1
is encoded by: hsa:501
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR PSt3
name: phosphatidylserine transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false

metaR NAGLCAly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
name: N-acetylglucosaminidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_424a3c8d_6bf7_47d5_a621_c5268a56246d
constant: false
name: NEU1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4758
is: Q99519
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM h2o2 c
is: SBO:0000247
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
name: Hydrogen peroxide
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: HMDB03125
type: Species

metaM 5aop m
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 5-Amino-4-oxopentanoate
is: HMDB01149
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false
initial concentration: 1.0
is: C00430
is: CHEBI:17549

metaM 2mbcoa m
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01041
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
type: Species
initial amount: NaN
is: CHEBI:57336

http://identifiers.org/biomodels.db/MODEL1310110017#_154ed2b9_24cf_4ed7_9988_73793d9e7df4
type: Species
initial amount: NaN
has part: E9KL44
has part: P55084
is: SBO:0000297
name: HADHA:HADHB
is encoded by: hsa:3032
is encoded by: hsa:3030
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_1a69cacf_e1fe_4051_aa6e_304021acf226
is encoded by: hsa:4722
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O75489
name: NDUFS3

http://identifiers.org/biomodels.db/MODEL1310110017#_2b24554d_02c3_4895_af2f_0559521e7377
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC7A5
is encoded by: hsa:8140
is: Q8IV97
type: Species
boundary condition: true
constant: false

metaR 5ADTSTSTERONESte
reactant: MODEL1310110017#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: sulfonated testosterone transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaM val L c
name: L-valine
type: Species
is: HMDB00883
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaR LEUTA
is: SBO:0000176
reversible: true
product: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
type: Reaction
name: leucine transaminase

metaR PGDI
is described by: ECO:0000269
is: SBO:0000176
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/5.3.99.2
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: true
kinetic law: MODEL1310110017#

metaR r0060
fast: false
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
product: MODEL1310110017#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM tchola c
initial amount: NaN
is: SBO:0000247
is: CHEBI:36257
is: HMDB00036
type: Species
name: taurocholic acid
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

http://identifiers.org/biomodels.db/MODEL1310110017#_ea870202_ba46_4723_bd2d_a3044dcabb95
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: NDUFS6
initial concentration: NaN
is encoded by: hsa:4726
is: Q6IBC4

metaR r2090
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
reversible: true

metaM paf hs e
has only substance units: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_2b6da8b9_0224_4151_af86_efb055a42d4e
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: HAO2
is encoded by: hsa:51179
boundary condition: true
has only substance units: false

metaM cholcoa c
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
initial amount: NaN
is: CHEBI:57373
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
is: HMDB01374

metaM chol g
is: HMDB00097
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
constant: false
has only substance units: false
is: CHEBI:15354
name: choline

metaR GLYCt
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reversible: true
fast: false
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: glycerol transport via channel
is described by: ECO:0000000
is: SBO:0000185

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
name: coenzyme A transport, peroxisomal
reversible: true
type: Reaction
fast: false

metaR THRGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110017#
is described by: ECO:0000304
kinetic law: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
type: Reaction
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110017#
fast: false
reversible: true

metaM hmgcoa m
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
initial amount: NaN
constant: false
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
is: HMDB01375
type: Species
has only substance units: false
is: CHEBI:15467

metaM HC02203 e
type: Species
has only substance units: false
is: CHEBI:27820
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
initial concentration: 1.0
name: prostaglandin-a2

http://identifiers.org/biomodels.db/MODEL1310110017#_62869026_7770_487c_ad11_e4535a8700cc
is: P36269
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2687
name: GGT5
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0062
is version of: http://identifiers.org/ec-code/4.3.1.17
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
is: SBO:0000176
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: false
product: MODEL1310110017#
is described by: ECO:0000000

metaR 34DHPLACOX NADP
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110017#
modifier: MODEL1310110017#
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
fast: false

metaM dgsn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
is: CHEBI:17172
initial concentration: 1.0
initial amount: NaN
is: C00330
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Deoxyguanosine
is: HMDB00085
type: Species

metaR RE2626C
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110017#
name: RE2626
is described by: ECO:0000000
type: Reaction

metaR NCKt
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
reversible: true
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: Na+/Ca2+-K+ exchange
product: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#

metaM h2o2 n
constant: false
name: hydrogen peroxide
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16240
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

http://identifiers.org/biomodels.db/MODEL1310110017#_b44f59fb_8fda_4fcf_a3d8_8d725582b7b3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5409
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: P11086
name: PNMT

metaR GCC2bim
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110017#
reactant: MODEL1310110017#

metaM tyr L c
constant: false
is: SBO:0000247
is: CHEBI:17895
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: HMDB00158
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR PI4PP
name: phosphatidylinositol-4-phosphate 4-phosphatase
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_07383c73_8ab0_4d37_9e2c_a68fb045b936
is: P14854
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: COX6B1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1340

metaM datp c
is: SBO:0000247
is: C00131
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
type: Species
name: dATP
has only substance units: false
boundary condition: false
is: HMDB01532

metaR r2092
product: MODEL1310110017#
type: Reaction
fast: false
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000

metaM retinal r
initial amount: NaN
name: retinal
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: HMDB01358
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035

metaR r0170
fast: false
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110017#

metaR ADRNLPVESSEC
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of adrnl from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
name: Adrenaline secretion via secretory vesicle (ATP driven)
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e474bf60_823e_48b4_b99b_8322219a44b7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:4717
name: NDUFC1
is: O43677
boundary condition: true
constant: false

metaM leuktrC4 c
constant: false
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
name: leukotriene C4(2-)
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01198
is: SBO:0000247

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM HC02213 c
name: prostaglandin-e3
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
is: CHEBI:28031
type: Species
boundary condition: false

metaR CH25H
is version of: http://identifiers.org/ec-code/1.14.99.38
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
name: cholesterol 25-hydroxylase
modifier: MODEL1310110017#
type: Reaction
is: SBO:0000176
reversible: false

metaR COAtr
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: COA transporter, endoplasmic reticulum
reversible: true
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110017#
reactant: MODEL1310110017#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR RDH1
fast: false
is: SBO:0000176
type: Reaction
name: retinol dehydrogenase (all-trans)
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
modifier: MODEL1310110017#
is described by: ECO:0000269
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_384b8700_5a96_4ada_8d9a_1253735613d2
has only substance units: false
name: BDH1
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:622
constant: false
initial amount: NaN
is: SBO:0000252

metaM HC00342 m
initial amount: NaN
name: cis-aconitate(3-)
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
is: CHEBI:16383
initial concentration: 1.0
has only substance units: false

metaR r1789
kinetic law: MODEL1310110017#
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000

metaM tyr L e
is: HMDB00158
name: L-tyrosine
type: Species
initial concentration: 1.0
is: CHEBI:17895
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaM glx c
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
name: glyoxylate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:36655
is: HMDB00119
type: Species

metaR CREATt4 2 r
reversible: true
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
product: MODEL1310110017#
fast: false
type: Reaction

metaM HC00900 c
is: SBO:0000247
name: Methylmalonate
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
initial concentration: 1.0

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_e5a879f1_a0fb_47ff_9c96_0fc267f5e5ae
is encoded by: hsa:4719
is: SBO:0000252
initial amount: NaN
type: Species
is: P28331
has only substance units: false
constant: false
boundary condition: true
name: NDUFS1
initial concentration: NaN

metaM amet m
is: C00019
type: Species
initial concentration: 1.0
name: S-Adenosyl-L-methionine
has only substance units: false
is: CHEBI:15414
is: HMDB01185
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_bf7d66a1_0346_4313_b636_fdd2acd95306
constant: false
has only substance units: false
initial amount: NaN
name: SGPP1
boundary condition: true
type: Species
is: Q9BX95
is encoded by: hsa:81537
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_b026a620_800b_487d_9f75_42601ebf4e12
name: RDH14
is: SBO:0000252
is encoded by: hsa:57665
boundary condition: true
type: Species
is: Q9HBH5
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM glcur r
initial concentration: 1.0
name: D-glucuronate
initial amount: NaN
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
is: SBO:0000247
boundary condition: false
is: HMDB00127

metaM dcmp c
is: CHEBI:57566
name: dCMP
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
has only substance units: false
is: C00239
is: SBO:0000247

metaM gam6p c
constant: false
is: SBO:0000247
is: HMDB01254
is: CHEBI:12962
type: Species
name: D-Glucosamine 6-phosphate
initial amount: NaN
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM glu L c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00148
name: L-glutamate(1-)
initial amount: NaN
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
has only substance units: false
is: CHEBI:29985

metaR GULNter
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
name: L-gulonate endoplasmic reticular export
reactant: MODEL1310110017#

metaM leuktrC4 e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57973
type: Species
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
boundary condition: false
is: HMDB01198
has only substance units: false
constant: false

metaM HC02213 e
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
is: CHEBI:28031
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_5506f21f_5211_4aa6_938c_23320aba759e
is encoded by: hsa:2954
initial concentration: NaN
name: GSTZ1
boundary condition: true
initial amount: NaN
is: O43708
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaM chol c
constant: false
boundary condition: false
is: HMDB00097
type: Species
initial amount: NaN
is: C00114
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
is: CHEBI:15354

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_2fbca7c8_1326_49ec_affd_8ab83456636b
type: Species
name: PRDX2
has only substance units: false
is encoded by: hsa:7001
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR GLYCTO1p
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: Glycolate oxidase, peroxisome
is version of: http://identifiers.org/ec-code/1.1.3.15
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false
product: MODEL1310110017#
is described by: ECO:0000269
reversible: false
type: Reaction

metaR r1788
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
modifier: MODEL1310110017#

metaR r2095
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_03f7fdd6_f290_41aa_9c91_58516a0f8e5f
initial concentration: NaN
is: O43674
initial amount: NaN
name: NDUFB5
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4711
type: Species

metaR DCK1n
kinetic law: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110017#
product: MODEL1310110017#

metaM glu5sa m
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
constant: false
is: C01165
is: CHEBI:17232
initial concentration: 1.0
initial amount: NaN
is: HMDB02104
has only substance units: false

metaM dad 2 c
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00101
is: CHEBI:17256
type: Species
name: 2-deoxyadenosine

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_973fe96a_dd2a_4577_901d_3dc443ad0ff3
is: Q99643
is encoded by: hsa:6391
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: SDHC
initial concentration: NaN
initial amount: NaN

metaR EX crmp hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ceramide 1-phosphate exchange
type: Reaction

metaM val L m
initial amount: NaN
type: Species
is: HMDB00883
name: L-valine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: CHEBI:16414
is: SBO:0000247
constant: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r2093
is: SBO:0000185
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
fast: false
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_0fc90695_72c3_422e_9aa4_23626a1eef23
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6579
is: P46721
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLCO1A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_b6f82c5e_dffc_4f5f_b717_0a141fe573aa
is: SBO:0000252
name: GALNT3
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q14435
constant: false
initial amount: NaN
is encoded by: hsa:2591
type: Species

metaM pglyc hs e
is: SBO:0000247
name: phosphatidylglycerol(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
constant: false
is: CHEBI:60523
boundary condition: false
initial amount: NaN

metaR LNLCCRNt
is: SBO:0000185
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
name: transport into the mitochondria (carnitine)
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110017#

metaM glcur l
is: HMDB00127
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
name: D-glucuronate
constant: false
is: SBO:0000247
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4e50af72_3d47_4919_8dcf_e93dcade0683
constant: false
name: PPA2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27068
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r2094
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110017#_c1a1c6c6_edf9_42d3_b535_d92e551b9f94
name: _C7orf24_1_m
type: Species
is encoded by: hsa:C7orf24
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_f710f066_7ca9_4625_ba8c_2efc3e89420a
has only substance units: false
is encoded by: hsa:218
type: Species
constant: false
name: ALDH3A1
is: P30838
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_025e82f8_22ee_4fac_9b01_3649b0f30a4f
initial concentration: NaN
is encoded by: hsa:10050
name: SLC17A4
is: SBO:0000252
is: Q9Y2C5
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR ADNK3
fast: false
name: adenosine kinase
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
reversible: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110017#_951e1975_b724_4d2f_9670_e3df5e246935
is: Q9Y5P6
is: SBO:0000252
boundary condition: true
name: GMPPB
type: Species
constant: false
is encoded by: hsa:29925
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM h2o2 m
is: SBO:0000247
is: HMDB03125
is: CHEBI:16240
has only substance units: false
type: Species
name: Hydrogen peroxide
is: C00027
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_d2de5b53_afef_4e7d_88a9_801099c6689d
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ALPP
is: P05187
is: SBO:0000252
is encoded by: hsa:250

metaM udpglcur r
is: HMDB00935
type: Species
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
is: SBO:0000247
is: C00167
initial concentration: 1.0
has only substance units: false
is: CHEBI:58052
boundary condition: false
name: UDP-D-glucuronate

metaM HC00591 m
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN
type: Species
is: CHEBI:16769
has only substance units: false
name: 2-oxoglutaramate

metaR ACGAMtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-glucosamine lysosomal efflux
is: SBO:0000185
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: false
fast: false

metaR r1786
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM chol e
constant: false
is: HMDB00097
type: Species
boundary condition: false
initial amount: NaN
is: C00114
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
has only substance units: false
name: Choline

http://identifiers.org/biomodels.db/MODEL1310110017#_b69a92b6_bd2f_47e1_82c1_6094a9917ba4
initial concentration: NaN
is encoded by: hsa:278
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: AMY1C
type: Species
boundary condition: true
constant: false
is: P04745

metaR r0926
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
fast: false
reversible: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
kinetic law: MODEL1310110017#

metaR UMPK7n
reactant: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
is: SBO:0000176
name: UMP kinase (dGTP),nuclear
fast: false
modifier: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_33674972_102c_41b0_b4c6_886873a2f4f7
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:48
type: Species
has only substance units: false
name: ACO1
constant: false
is: P21399
initial concentration: NaN

metaR r2097
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM dgsn e
is: C00330
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
initial concentration: 1.0
name: Deoxyguanosine
type: Species
is: HMDB00085
boundary condition: false
constant: false
is: CHEBI:17172
initial amount: NaN

metaR r1933
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r1785
fast: false
kinetic law: MODEL1310110017#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110017#
reversible: false
modifier: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_035e5c83_647d_410e_ad0b_2f294960c4b5
is encoded by: hsa:AA854479
is: SBO:0000252
name: _AA854479_1_m
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000000

metaR MDHm
modifier: MODEL1310110017#
is: SBO:0000176
type: Reaction
reversible: true
name: malate dehydrogenase, mitochondrial
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000134
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_51cc0ee6_a6a4_49f0_b48a_f89aa206e3b7
constant: false
name: ACADVL
initial amount: NaN
is encoded by: hsa:37
is: P49748
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaR ACt2m
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: acetate mitochondrial transport via proton symport
type: Reaction
is: SBO:0000185
reversible: true

metaM o2s x
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: superoxide
is: HMDB02168
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0

metaR r2088
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true

metaM lac D c
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: HMDB01311
is: CHEBI:16004
is: SBO:0000247
initial concentration: 1.0
name: (R)-lactate

metaM nrpphr c
is: SBO:0000247
initial amount: NaN
is: HMDB00216
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false
type: Species
is: CHEBI:33569
name: Norepinephrine

metaM h2o2 x
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: HMDB03125
is: C00027
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16240
initial amount: NaN
constant: false

metaM h2o r
initial concentration: 1.0
boundary condition: false
name: H2O
is: CHEBI:15377
is: C00001
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02111
has only substance units: false

metaR r0281
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
fast: false

metaM ksii core2 e
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
name: keratan sulfate II (core 2-linked)
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00211
is: CHEBI:17268
initial amount: NaN
is: SBO:0000247

metaR GGH 5DHFl
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaR r0788
fast: false
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: true
reactant: MODEL1310110017#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110017#_87469b6b_351b_4637_bdb8_e1786fb26205
initial amount: NaN
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
name: FOLR1
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR HACD9m
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110017#
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

metaR r2089
type: Reaction
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_062b0f8d_528a_4986_9b9c_1c17b018e725
is: P48651
name: PTDSS1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9791
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_e03c9e94_503b_4af2_a3a0_6a08cfb2e6eb
name: _AA021081_1_r
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA021081
initial concentration: NaN
type: Species

metaM lpam m
name: lipoamide
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00962
is: CHEBI:17460
boundary condition: false
is: SBO:0000247
constant: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR O2Stx
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
name: superoxide anion transport via diffusion (peroxisome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_f344b5ee_2bed_470e_b16b_5dd654975fa0
type: Species
is: O94788
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: ALDH1A2
is encoded by: hsa:8854
initial amount: NaN
boundary condition: true

metaR RE1526M
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: RE1526
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r0787
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
fast: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_f368acd1_df27_49d6_bdc2_5aa545e4c80a
is: SBO:0000252
is: Q9H0I9
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: TKTL2
constant: false
boundary condition: true
is encoded by: hsa:84076
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_47e2c69e_fba4_4ab9_934d_90d424c95998
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3030
constant: false
type: Species
name: HADHA
is: E9KL44
initial concentration: NaN
initial amount: NaN

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR r1670
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
type: Reaction
reversible: true
name: Y+LAT2 Utilized transport
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176
name: RE1532
modifier: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f7b3076b_1d80_4c20_be5c_34c09250e1ec
name: SLC25A20
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:788
initial amount: NaN
type: Species
is: O43772
is: SBO:0000252

metaM CE0785 m
initial concentration: 1.0
is: C01936
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r0339
fast: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
reactant: MODEL1310110017#

metaM dhlam m
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00985
constant: false
initial amount: NaN
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
name: dihydrolipoamide

metaR r2086
fast: false
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR LNLCCPT2
reversible: false
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
name: carnitine transferase
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176

metaR HACD1m
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
modifier: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_6bb25114_47b1_4ed2_afbe_cd0c30b016f6
is: O00624
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: SLC17A2
has only substance units: false
is encoded by: hsa:10246
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_2a4b8418_e5b0_4728_bbd5_dba7d41cd628
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110017#_18d8164f_a062_4168_b76d_113bd597deee
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaM Ser Thr g
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB00143
is: C00124
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: CHEBI:0
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c5bc9695_744f_46ec_aba1_bb5f286a2075
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110017#_51d5b23b_e11a_42be_a767_313345f93657
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: SLC27A1
is encoded by: hsa:376497
has only substance units: false
type: Species
initial concentration: NaN
is: Q6PCB7

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaM thcholstoic c
type: Species
has only substance units: false
is: HMDB03873
is: CHEBI:18402
constant: false
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_28c67e67_ae91_4673_828a_cf4d277c0297
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: GPI
initial amount: NaN
constant: false
is encoded by: hsa:2821
is: P06744

metaR r2087
is: SBO:0000185
fast: false
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#

metaR DTDPtn
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
name: dTDP nuclear transport
is: SBO:0000185
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_59c57f5f_ae7c_496a_a370_93ca1dd253d1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5052
initial amount: NaN
constant: false
initial concentration: NaN
name: PRDX1

http://identifiers.org/biomodels.db/MODEL1310110017#_f58bdda8_d5ac_437b_b437_43397351c7ab
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q9Y666
initial amount: NaN
name: SLC12A7
is encoded by: hsa:10723
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_b11d5a5d_bda6_49b5_aa4f_3db00da3f928
is: E7EPT3
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:501
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ALDH7A1

metaR ABUTt2r
reversible: true
is: SBO:0000185
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is described by: ECO:0000304
reactant: MODEL1310110017#
name: 4-aminobutyrate reversible transport in via proton symport

metaR LNLCCPT1
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
reversible: false
type: Reaction

metaR DGULND
name: dehydro-L-gulonate decarboxylase
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR r0660
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
is: SBO:0000176
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_349f2994_d598_44ab_a4ba_d48821412a3f
name: VNN2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: A8K7W0
is: SBO:0000252
constant: false
is encoded by: hsa:8875
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_da5d141e_81e2_435a_bef5_605154e1e5d2
is: Q96KJ9
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:84701
initial concentration: NaN
type: Species
name: COX4I2
has only substance units: false
is: SBO:0000252

metaM retinol 9 cis c
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06217
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
name: 9-cis-retinol
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17336

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR INSTt4 2
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
product: MODEL1310110017#
type: Reaction
fast: false
name: inositol transport via sodium symport
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_f0d947fc_5456_4f5d_a509_413921007d61
initial amount: NaN
name: CLYBL
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:171425

metaR CYTK14
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (dCMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#

metaM h2o n
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB02111
name: water
type: Species
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110017#_2e78f5e0_741c_4ca8_a1c5_8d7bdec82cd3
is: O76082
boundary condition: true
is encoded by: hsa:6584
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC22A5
type: Species

metaM frdp c
is: CHEBI:175763
name: Farnesyl diphosphate
is: HMDB00961
is: C00448
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species

metaR r0784
product: MODEL1310110017#
reversible: true
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR CO2ter
is: SBO:0000185
reversible: true
type: Reaction
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ce427bfc_7c22_49c7_a654_c09222ace7a9
initial amount: NaN
initial concentration: NaN
name: NDUFS2
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: B7Z792
is encoded by: hsa:4720

http://identifiers.org/biomodels.db/MODEL1310110017#_b79b5f98_5fb3_443c_8b28_ad2930fe78c6
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54363
constant: false
is: Q9UJM8
has only substance units: false
initial concentration: NaN
name: HAO1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_0ff00326_efcd_4a4a_aec9_a2c3033f0395
initial concentration: NaN
name: SLC20A1
constant: false
is: SBO:0000252
is: Q8WUM9
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6574

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_b9525887_21ee_4899_853a_a358e11cfa79
constant: false
is: SBO:0000252
is encoded by: hsa:224
type: Species
boundary condition: true
is: P51648
initial amount: NaN
initial concentration: NaN
name: ALDH3A2
has only substance units: false

metaM cytd e
boundary condition: false
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
name: Cytidine
type: Species
is: HMDB00089
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:17562
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_c41a799d_61fa_406c_9fd7_764c73e8c92e
type: Species
is encoded by: hsa:257202
name: GPX6
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P59796

metaR CYTK13
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7383c23e_8cdd_4f80_8504_d84ae118a8a8
is: Q9H2H9
is: SBO:0000252
name: SLC38A1
is encoded by: hsa:81539
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR UMPKn
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
modifier: MODEL1310110017#
name: UMP kinase, nuclear

metaR r0783
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_721a6246_4cdc_42f0_80d8_738722e0fbcd
has only substance units: false
name: CA5A
constant: false
is: P35218
is encoded by: hsa:763
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_0942b7b8_c66b_4b17_9847_726a3adf8fa8
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ALDH3B2
is encoded by: hsa:222
constant: false
type: Species
is: SBO:0000252
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110017#_1685e963_790e_407e_a818_06d9edc38d4e
constant: false
name: DGKH
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8K0I1
is encoded by: hsa:160851
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r1569
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true

metaR CYTK12
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
reversible: true
name: cytidylate kinase (dCMP,dCTP)
kinetic law: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110017#
fast: false
is: SBO:0000176
type: Reaction

metaM lac D e
is: SBO:0000247
is: HMDB01311
constant: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
name: (R)-lactate
initial amount: NaN
is: CHEBI:16004
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM nrpphr e
initial amount: NaN
is: SBO:0000247
is: HMDB00216
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: Norepinephrine
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

http://identifiers.org/biomodels.db/MODEL1310110017#_729eb15a_08c4_4c65_a3d3_57b256cb4b28
constant: false
is encoded by: hsa:570
initial concentration: NaN
type: Species
name: BAAT
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q14032
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_8177b014_4e14_4289_bdca_09a107fce375
name: _D29675_1_c
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:D29675
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2371
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110017#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR RE2799C
reactant: MODEL1310110017#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
name: RE2799

metaM gcald c
name: glycolaldehyde
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: CHEBI:17071
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB03344

metaR r1568
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM cytd c
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
is: C00475
constant: false
has only substance units: false
type: Species
is: HMDB00089
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17562

metaR CYTK11
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_3c98f892_bb17_4bfe_a44d_608eba6cf90f
is: Q9BZV2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: SLC19A3
is: SBO:0000252
is encoded by: hsa:80704

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r2372
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR 5MTHFt2le
is described by: ECO:0000134
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_21d03c41_cbe9_46de_a30d_e084ce00296d
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q548A7
initial concentration: NaN
type: Species
name: SLC26A6
boundary condition: true
is encoded by: hsa:65010
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_dae5337e_2032_43c4_80ef_d8199a815fbf
is encoded by: hsa:5092
initial amount: NaN
is: SBO:0000252
name: PCBD1
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaM lnlccoa r
constant: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM andrstandn r
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00899
initial concentration: 1.0
constant: false
name: 5alpha-androstane-3,17-dione
is: CHEBI:15994
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_375645b8_7e05_44d2_b64c_3732fd190279
is: SBO:0000252
name: GPX1
type: Species
is encoded by: hsa:2876
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_0def220b_032d_4432_9b4a_b49e42c57f4e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:29920
type: Species
is: Q96C36
has only substance units: false
boundary condition: true
name: PYCR2

metaR q10tm
product: MODEL1310110017#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of ubiquinone into mitochondria

metaM dgchol e
boundary condition: false
is: CHEBI:36252
constant: false
is: HMDB00637
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
initial concentration: 1.0
type: Species
has only substance units: false

metaR PAIL45P HStn
product: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110017#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true

metaR r1567
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR r1566
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
type: Reaction
fast: false
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.8

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r0394
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110017#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
reversible: true

metaM dcacoa m
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: SBO:0000247
constant: false
is: CHEBI:61430
is: HMDB06404
initial concentration: 1.0
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_2aab7c70_a7c9_4d0d_b333_1c840c766bec
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29085
boundary condition: true
name: PHPT1
is: Q9P019
initial amount: NaN
constant: false

metaM pyr c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1
boundary condition: false
name: pyruvate
is: CHEBI:15361
is: HMDB00243
constant: false
is: C00022
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324

metaR r1679
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#

metaR r0558
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
reversible: true

metaM ctp c
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
is: SBO:0000247
name: CTP
constant: false
initial concentration: 1.0
is: C00063
is: HMDB00082
has only substance units: false
initial amount: NaN

metaM duri c
name: Deoxyuridine
boundary condition: false
type: Species
is: C00526
is: HMDB00012
has only substance units: false
initial amount: NaN
is: CHEBI:16450
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
initial concentration: 1.0

metaM prostgf2 c
is: SBO:0000247
constant: false
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01139
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR r2373
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true

metaR CYTK10
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,dGTP)
modifier: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
fast: false

metaR r1565
kinetic law: MODEL1310110017#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
reactant: MODEL1310110017#

metaM dgchol c
is: HMDB00637
name: glycochenodeoxycholate
type: Species
is: CHEBI:36252
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false

metaR r0330
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
fast: false

metaR r1678
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#

metaR r0393
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110017#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110017#_3ef396d7_c7c8_4973_a763_24f6d6232e9a
is: SBO:0000252
has only substance units: false
constant: false
is: P30838
boundary condition: true
name: ALDH3A1
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:218

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial concentration: 1.0
is: CHEBI:28325
constant: false
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r0557
modifier: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaR MALtm
fast: false
name: malate transport, mitochondrial
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_5c5a5b24_3031_418e_b119_d867816a4c4a
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1103
is: Q6LEN6
constant: false
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110017#_e4d9c759_6f90_4d53_bf87_eb40b5ee26a1
name: FOLR1
constant: false
is encoded by: hsa:2348
initial concentration: NaN
is: P15328
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaM 2mp2coa m
initial amount: NaN
has only substance units: false
name: 2-Methylprop-2-enoyl-CoA
is: CHEBI:27754
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01011
initial concentration: 1.0

metaR DTTPtn
is: SBO:0000185
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110017#
reversible: true

metaM C02470 c
is: http://identifiers.org/pubchem.compound/5485
type: Species
initial amount: NaN
name: Xanthurenic acid
constant: false
has only substance units: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: C02470
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00881

metaR r2374
kinetic law: MODEL1310110017#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110017#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM pyr e
is: SBO:0000247
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00243
constant: false
name: pyruvate
initial amount: NaN

metaM ade c
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
name: Adenine
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16708
is: HMDB00034
boundary condition: false
is: C00147

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR RE3568C
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
reversible: true
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110017#
fast: false
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r0556
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: true
type: Reaction

metaR BILGLCURtr
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
name: glucuronidated compound transport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction

metaM 34dhmald c
constant: false
type: Species
is: SBO:0000247
is: HMDB06242
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
name: 3,4-Dihydroxymandelaldehyde
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_d89562a2_a7a6_4ccf_8ea5_27792d44f6ef
is encoded by: hsa:3037
is: SBO:0000252
constant: false
name: HAS2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q92819
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_51f85cd4_1b85_4df2_a350_cbfdc877ec6e
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1632
name: ECI1
boundary condition: true
initial amount: NaN
is: P42126
constant: false

metaM prostgf2 e
type: Species
initial amount: NaN
is: CHEBI:57404
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
is: HMDB01139
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR r2375
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110017#
is: SBO:0000185
reversible: true

metaR 6DHFtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
reversible: false
product: MODEL1310110017#
name: 6-glutamyl-DHF transport, lysosomal
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR r0395
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_adec6cdc_1681_432c_95c4_54b33f592041
initial amount: NaN
is encoded by: hsa:130
is: SBO:0000252
initial concentration: NaN
name: ADH6
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P28332

metaR r1563
reactant: MODEL1310110017#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185

metaM 10fthf m
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
is: CHEBI:57454
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00972
initial amount: NaN

metaM 6a2ohxnt x
initial amount: NaN
constant: false
name: 6-amino-2-oxohexanoic acid
is: HMDB12151
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17534

http://identifiers.org/biomodels.db/MODEL1310110017#_11476fa3_582d_467e_a7e1_cab863ca1310
is: B4DZR2
initial amount: NaN
initial concentration: NaN
name: ALDH1A2
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8854
has only substance units: false

metaM dhap x
boundary condition: false
is: C00111
initial concentration: 1.0
is: HMDB01473
has only substance units: false
type: Species
is: CHEBI:57642
initial amount: NaN
is: SBO:0000247
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
constant: false

metaR DNDPt33m
reversible: false
name: dGDP transport via dUDP antiport
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#

metaM cyan e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18407
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
name: hydrogen cyanide
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR INSt
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
name: Inosine transport (diffusion)

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110017#
fast: false
reversible: true
reactant: MODEL1310110017#

metaR OROTGLUt
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_120fdc25_954e_4cd5_aac4_bfffa1f871d9
type: Species
is: A0PJK1
name: SLC5A10
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:125206
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_0b41e185_c1e5_4374_bc2d_e7e576ef0601
is: Q8NFF5
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: FLAD1
is encoded by: hsa:80308
initial concentration: NaN

metaR TKT2
type: Reaction
product: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
kinetic law: MODEL1310110017#
name: transketolase
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_2d0ab8cc_1143_4209_801e_a6a9c668b414
name: PGK2
is: SBO:0000252
is encoded by: hsa:5232
is: P07205
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110017#

metaM glyclt x
type: Species
initial concentration: 1.0
is: CHEBI:29805
initial amount: NaN
has only substance units: false
is: HMDB00115
is: SBO:0000247
name: glycolate
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_756f70a6_dcbc_42be_9b21_6f56645c6ad0
type: Species
initial concentration: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:4830
constant: false
initial amount: NaN
has only substance units: false
name: NME1:NME2

metaR r0390
fast: false
kinetic law: MODEL1310110017#
reversible: true
is: SBO:0000176
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_4e9260ed_ccf5_4ca2_9674_bfdfd0691428
type: Species
name: ACADM
boundary condition: true
is encoded by: hsa:34
is: P11310
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR NRPPHRt4 2 r
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000269
name: Norepinephrine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110017#
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_59c48304_4103_4103_a69a_68837769c099
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: VNN1
initial concentration: NaN
is encoded by: hsa:8876
is: O95497
initial amount: NaN
type: Species

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_a9bd1f61_07a8_4e88_8420_1262cc01818f
is: SBO:0000252
has only substance units: false
name: HSD11B1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3290
is: P28845
constant: false

metaM cytd m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00089
name: cytidine
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
has only substance units: false
is: CHEBI:17562

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_d4a036ee_4bd9_41d5_ad20_5a71ab979fd4
is: Q32NB8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9489
boundary condition: true
initial concentration: NaN
name: PGS1
constant: false
initial amount: NaN
type: Species

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM ps hs e
has only substance units: false
constant: false
name: phosphatidylserine
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
type: Species

metaR r2377
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110017#

metaR 3HCO3 NAt
fast: false
is: SBO:0000185
name: 3HCO3_NAt
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110017#

metaM udpglcur c
is: HMDB00935
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
constant: false
type: Species
name: UDP-D-glucuronate
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR CYTK13n
reversible: true
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is: SBO:0000176
name: cytidylate kinase (dCMP,dATP),nuclear

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
reactant: MODEL1310110017#
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#

metaR r1561
is: SBO:0000185
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110017#_1cc6b892_c9e4_4328_86f6_cb0b4e03708a
is: P04075
is: SBO:0000252
is encoded by: hsa:226
type: Species
boundary condition: true
name: ALDOA
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaM focytC m
initial amount: NaN
type: Species
name: Ferrocytochrome C
is: SBO:0000247
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial concentration: 1.0
constant: false
is: CHEBI:16928
has only substance units: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM dcmp n
is: CHEBI:57566
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
name: dCMP(2-)
is: HMDB01202

metaR 6DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: 6-glutamyl-DHF transport,m mitochondrial
product: MODEL1310110017#
type: Reaction
reversible: false
is described by: ECO:0000000

metaR HSD11B1r
is described by: ECO:0000269
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
product: MODEL1310110017#
name: 11-beta-hydroxysteroid dehydrogenase type 1
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.146
type: Reaction

metaR r2378
fast: false
reactant: MODEL1310110017#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM nac c
name: Nicotinate
constant: false
is: C00253
boundary condition: false
is: CHEBI:0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
is: HMDB01488

http://identifiers.org/biomodels.db/MODEL1310110017#_35b02191_90b7_4b24_843e_498a5ca6bf93
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: DHFR
is encoded by: hsa:1719
initial concentration: NaN
is: P00374
constant: false

metaM gtp c
boundary condition: false
is: SBO:0000247
is: CHEBI:37565
is: C00044
type: Species
name: GTP
has only substance units: false
is: HMDB01273
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0

metaM cyan c
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
is: CHEBI:18407
boundary condition: false
is: HMDB02084
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0552
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.5.1

metaR r1560
fast: false
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ctp e
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: CHEBI:37563
is: HMDB00082
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial amount: NaN
initial concentration: 1.0
is: HMDB01252
has only substance units: false
constant: false
is: CHEBI:15710
is: SBO:0000247
type: Species
name: betaine aldehyde
boundary condition: false

metaR r0179
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true
kinetic law: MODEL1310110017#

metaM 4mlacac c
type: Species
name: 4-maleylacetoacetate
is: CHEBI:17105
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02052
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036

metaR EX adrnl LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adrenaline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_969eca11_fede_4a05_8cd5_9bed8828df52
initial concentration: NaN
name: ATG9B
is: Q674R7
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:285973

metaR r0392
fast: false
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110017#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000

metaM h2o x
is: CHEBI:15377
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: H2O
constant: false
has only substance units: false
is: HMDB02111

metaR r2379
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_8e0afae9_d9f2_482c_8eba_2f28be569685
is encoded by: hsa:2348
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: FOLR1

metaM Ser Thr l
initial concentration: 1.0
boundary condition: false
type: Species
is: C00459
is: SBO:0000247
constant: false
is: CHEBI:37568
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB01342
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)

metaR TKT1
kinetic law: MODEL1310110017#
is described by: ECO:0000000
name: transketolase
modifier: MODEL1310110017#
is: SBO:0000176
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction

metaR SUCOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: Succinate--CoA ligase (GDP-forming)

metaM dhbpt c
name: 6,7-dihydrobiopterin
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
initial concentration: 1.0
is: CHEBI:20680
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_84e035fa_10fc_4bd4_8a6d_3cebe3b0f694
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1119
name: CHKA
is: P35790
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_065fde4c_a64f_4ae0_b1c7_60dfb304a11d
is: Q9UJ70
initial amount: NaN
has only substance units: false
type: Species
name: NAGK
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55577
constant: false

metaM 6pgl r
is: CHEBI:57955
initial amount: NaN
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: HMDB01127
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_69a775fa_63c2_4803_9453_acc49c353796
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5167
is: P22413
boundary condition: true
name: ENPP1
initial concentration: NaN
is: SBO:0000252

metaM nac e
is: C00253
name: Nicotinate
boundary condition: false
is: CHEBI:0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01488
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false
initial concentration: 1.0
constant: false

metaM HC02121 c
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
constant: false
is: CHEBI:58758
name: S-(hydroxymethyl)glutathione(1-)
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_94fd66b3_ab01_44ab_a1de_35f1bdeab269
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2639
name: GCDH
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR NADPtru
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
is: SBO:0000185
name: NADP transporter, endoplasmic reticulum
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaM cmp m
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
type: Species
boundary condition: false
constant: false
name: CMP(2-)
has only substance units: false

metaM co2 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01967
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
constant: false
is: CHEBI:16526
name: CO2
is: C00011
has only substance units: false

metaR SRTNtu
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
name: Serotonin uniport

metaR LEUKTRE4t
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
name: leukotriene E4 transport
reversible: true
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_83ca6e62_6c77_4aec_b899_5c1151a8a5dc
name: LCT
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3938
initial concentration: NaN
is: P09848
type: Species
boundary condition: true

metaM fad e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
type: Species
is: CHEBI:16238
initial amount: NaN
constant: false
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110017#_e7f518ea_4961_4d6e_97cf_769ced36966e
name: _AI631997_1_m
is encoded by: hsa:AI631997
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_d5e808ef_367e_43b0_8e51_d603a7a7086c
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:10455
type: Species
name: ECI2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O75521

http://identifiers.org/biomodels.db/MODEL1310110017#_ec15ad08_a588_4ffe_bc9c_3abe861aa30f
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:56994
is: SBO:0000252
has only substance units: false
name: CHPT1
is: Q8WUD6
constant: false
initial amount: NaN

metaR LDH D
fast: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reversible: true
is described by: ECO:0000304
is: SBO:0000176
name: D-lactate dehydrogenase
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.2.4

metaM nadp m
type: Species
initial amount: NaN
is: HMDB00217
is: CHEBI:58349
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
is: SBO:0000247
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
has only substance units: false

metaR RE1897C
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
name: RE1897

metaR DGCHOLte
is described by: ECO:0000000
reactant: MODEL1310110017#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
product: MODEL1310110017#
fast: false
reversible: true
kinetic law: MODEL1310110017#
type: Reaction

metaR r2369
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
reversible: true

metaR URAt
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: uracil transport via facilated diffusion
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_e07234a1_f77e_492b_a934_8e600df1d497
is encoded by: hsa:8833
type: Species
boundary condition: true
is: SBO:0000252
is: P49915
initial concentration: NaN
initial amount: NaN
name: GMPS
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_1ba95f9b_16f0_4998_8ffe_8c4e56cc3088
is encoded by: hsa:54407
type: Species
is: Q96QD8
is: SBO:0000252
name: SLC38A2
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_8a579222_0185_4d92_91ba_a0ecbb9e26ba
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8801
type: Species
name: SUCLG2
is: SBO:0000252
constant: false
has only substance units: false
is: Q96I99
initial amount: NaN

metaR r1570
product: MODEL1310110017#
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM thr L e
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
is: CHEBI:16857
boundary condition: false
name: L-threonine
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00167

metaR NAIt
name: Na+ / iodide cotransport
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110017#
fast: false
reversible: true
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_d20e6105_5362_46d2_aa74_726378a49874
is encoded by: hsa:10559
initial concentration: NaN
name: SLC35A1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P78382
type: Species
constant: false
initial amount: NaN

metaM succoa m
constant: false
name: Succinyl-CoA
initial amount: NaN
has only substance units: false
is: CHEBI:57292
is: HMDB01022
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_32b066f0_369d_41cb_89fa_698edba45c09
is encoded by: hsa:AI924226
has only substance units: false
initial amount: NaN
name: _AI924226_1_m
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM L2aadp m
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
is: CHEBI:58672
is: SBO:0000247
initial concentration: 1.0
is: HMDB00510
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaM pyr m
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
name: pyruvate
is: HMDB00243
is: C00022
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
is: SBO:0000247

metaM xol7aone c
is: CHEBI:17899
is: HMDB01993
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
type: Species

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_e4869735_56b3_4161_a96c_426d8b167451
constant: false
initial concentration: NaN
is encoded by: hsa:3418
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: IDH2
is: P48735
is: SBO:0000252

metaM bamppald c
boundary condition: false
name: beta-Aminopropion aldehyde
has only substance units: false
is: C05665
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: HMDB01106
is: SBO:0000247

metaM fad c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: C00016
type: Species
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9f134e4f_c503_42cf_a8aa_87a23298316a
is encoded by: hsa:2987
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q16774
name: GUK1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM cdpdag hs m
initial amount: NaN
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
constant: false

metaM CE2838 e
name: maltononaose
type: Species
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110017#_8af935be_3ef8_4ed9_9b8e_7ea9f2012d71
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:170712
boundary condition: true
is: Q8TF08
constant: false
name: COX7B2
is: SBO:0000252
has only substance units: false

metaR BILDGLCURt
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_79f814c6_ebf0_42c9_9ada_1dcec6cb960e
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6482
name: ST3GAL1

http://identifiers.org/biomodels.db/MODEL1310110017#_b7bf2b45_b285_413c_9a70_a9fd49f645f4
initial amount: NaN
is encoded by: hsa:2678
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: GGT1
initial concentration: NaN
is: P19440
type: Species

metaM udpacgal g
is: HMDB00304
is: CHEBI:57847
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
type: Species
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR RE0915E
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
name: RE0915
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110017#
fast: false

metaR RE3272N
product: MODEL1310110017#
type: Reaction
fast: false
is: SBO:0000176
reversible: true
name: RE3272
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
kinetic law: MODEL1310110017#

metaM lys L c
is: CHEBI:32551
name: L-lysinium(1+)
initial amount: NaN
is: HMDB00182
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaR q10h2tc
is described by: ECO:0000134
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of ubiquinol into cytosol
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_e8d7c242_92f7_4e5a_8c6c_8baa4f512ef7
boundary condition: true
name: _AA278423_1_c
constant: false
initial amount: NaN
is encoded by: hsa:AA278423
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_f7351f2d_7ea3_4bf9_a00e_40ba088187a6
boundary condition: true
is encoded by: hsa:314
type: Species
name: AOC2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0186
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110017#
is: SBO:0000176
reversible: false
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR PGPPT
name: phosphatidyl-CMP: glycerophosphate phosphatidyltransferase
reversible: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.8.5
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9489.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 2 AUTHORS: PMID:10799718 NOTES:NJ
type: Reaction
product: MODEL1310110017#
is: SBO:0000176

metaR CITRtm
reversible: true
is: SBO:0000185
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_1c63725e_1f2b_492c_ae99_983abd17ce3c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: GMPPA
constant: false
type: Species
is encoded by: hsa:29926
has only substance units: false
is: Q96IJ6
initial amount: NaN

metaR r1790
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110017#
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110017#_82e177d1_99d6_4f97_8684_8bf452259343
name: SLC7A8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23428
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: Q86U05

metaR r0385
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110017#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000176
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110017#

metaR CYTK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110017#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
reactant: MODEL1310110017#

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27
product: MODEL1310110017#
reversible: false
is described by: ECO:0000269
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4631f489_aac5_48c2_8a7b_2cb06d670797
is: Q5JZF5
name: ALAS2
type: Species
has only substance units: false
is encoded by: hsa:212
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_36f8ab75_6eb6_4e61_a1d5_ce0d694950aa
is: Q9NS18
name: GLRX2
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:51022
boundary condition: true

metaM dhap c
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
is: C00111
initial concentration: 1.0
constant: false
is: CHEBI:57642
has only substance units: false
is: HMDB01473
name: Dihydroxyacetone phosphate
initial amount: NaN

metaR GTHP
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110017#
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12

metaM ade e
is: HMDB00034
boundary condition: false
name: adenine
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16708
type: Species

metaM methf m
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
has only substance units: false
is: HMDB01354
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
is: CHEBI:57455
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_2560fb70_cd3d_4afa_a9cb_9e75fd7e0e1d
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: SLC25A6
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:293
is: Q6I9V5

http://identifiers.org/biomodels.db/MODEL1310110017#_51c23572_f577_44ff_9810_590fce2f75ab
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:H45672
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: _H45672_1_m

metaM cmp g
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00095
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: CHEBI:60377
initial amount: NaN
constant: false
initial concentration: 1.0

metaR AMPtp
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reversible: true
type: Reaction
product: MODEL1310110017#
name: AMP transporter, peroxisome
kinetic law: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_3f22b003_3a61_419f_b9ed_0e266b679ce7
is: Q8WUX1
has only substance units: false
is: SBO:0000252
name: SLC38A5
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:92745
type: Species

metaM gtp m
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: C00044
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01273
name: GTP
is: CHEBI:37565
boundary condition: false
type: Species

metaR RE0926E
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
modifier: MODEL1310110017#
name: RE0926
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110017#_1312f686_257e_44bb_877b_62c76372c691
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2880
name: GPX5
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: O75715

metaM lys L e
is: CHEBI:32551
constant: false
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
name: L-lysinium(1+)
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

metaR BTNt4i
reversible: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
fast: false
is: SBO:0000185
name: Biotin uptake (antiport)

metaM pac c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18401
name: phenylacetate
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
boundary condition: false
is: HMDB00209
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_e8067b0b_4b17_4a04_8ee5_50ea20ec255d
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:2875
type: Species
is: P24298
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GPT

metaM udpg r
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
initial concentration: 1.0
type: Species
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
has only substance units: false
is: CHEBI:58367
constant: false

metaR RE1903R
reactant: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
product: MODEL1310110017#
name: RE1903
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000000

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM HC01609 e
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: UroporphyrinogenI
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: CHEBI:28766
initial concentration: 1.0
has only substance units: false

metaR NRPPHRtu
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: Norepinephrine uniport
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_72b5ee2d_b065_47a8_964a_3c9d045ef0f2
name: NDUFA3
type: Species
is: SBO:0000252
is: O95167
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:4696
boundary condition: true

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM thr L c
is: CHEBI:16857
constant: false
initial concentration: 1.0
is: HMDB00167
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR LEUTAm
fast: false
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110017#
name: leucine transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
kinetic law: MODEL1310110017#
reversible: true
is described by: ECO:0000269
type: Reaction

metaR r0559
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
type: Reaction

metaM nadph c
type: Species
is: C00005
is: HMDB00221
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
is: CHEBI:57783
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247

metaR FUMSO3tm
is described by: ECO:0000269
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
name: Fumarate:sulfite antiport, mitochondrial
modifier: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
is: SBO:0000185

metaR RE1519M
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110017#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519

metaM o2s m
is: CHEBI:18421
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Superoxide anion
is: C00704

metaR PE HStm
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110017#

metaM udpacgal c
constant: false
type: Species
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
initial amount: NaN
is: HMDB00304
boundary condition: false
is: CHEBI:57847

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: 2,5-dihydroxybenzoate
is: SBO:0000247
is: CHEBI:58044
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_5c677c34_676a_4c93_aa21_d370c2305379
has only substance units: false
name: ALDH2
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: P05091
is: SBO:0000252
type: Species
is encoded by: hsa:217

metaM lnlccoa c
is: SBO:0000247
name: linoleic coenzyme A
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: http://identifiers.org/pubchem.compound/5462164

http://identifiers.org/biomodels.db/MODEL1310110017#_1b134d07_3ee2_432b_a2bf_6fedbe2b3f65
initial amount: NaN
is: P21912
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: SDHB
type: Species
is encoded by: hsa:6390
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_762c37a4_c4c5_40a6_a3a1_b6db48293e40
is encoded by: hsa:6560
initial amount: NaN
is: F5H066
boundary condition: true
constant: false
name: SLC12A4
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM duri e
is: C00526
name: Deoxyuridine
is: HMDB00012
is: CHEBI:16450
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
type: Species
initial amount: NaN

metaM dhap e
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57642
is: HMDB01473
name: glycerone phosphate(2-)
initial amount: NaN
has only substance units: false

metaM ptrc e
type: Species
has only substance units: false
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
constant: false
name: Putrescine
boundary condition: false
is: CHEBI:326268
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01414

metaM co2 e
is: CHEBI:16526
name: CO2
is: SBO:0000247
type: Species
is: HMDB01967
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
constant: false
has only substance units: false
is: C00011
boundary condition: false

metaM cmp e
name: CMP(2-)
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
type: Species
is: CHEBI:60377
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR 13DAMPPOX
is described by: ECO:0000212
reversible: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
modifier: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
kinetic law: MODEL1310110017#

metaM glyb c
constant: false
name: glycine betaine
initial amount: NaN
is: HMDB00043
is: SBO:0000247
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaM o2s n
type: Species
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB02168
is: CHEBI:18421
boundary condition: false
name: superoxide

metaR r1791
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
reversible: false
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#

metaM CE2705 c
constant: false
initial amount: NaN
is: CHEBI:36781
name: quinonoid dihydrobiopterin
is: SBO:0000247
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM arachd r
has only substance units: false
is: HMDB01043
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
constant: false
is: CHEBI:32395
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR NADPHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: NADPH transporter, endoplasmic reticulum
reversible: false
product: MODEL1310110017#

metaR r2080
kinetic law: MODEL1310110017#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_5f4447b7_86b4_4bec_859b_9f404f9f7489
type: Species
initial concentration: NaN
is encoded by: hsa:374291
has only substance units: false
boundary condition: true
name: NDUFS7
is: O75251
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_9fe38386_3fe0_451b_bdf3_c39471930b99
initial concentration: NaN
is encoded by: hsa:2194
has only substance units: false
type: Species
name: FASN
is: SBO:0000252
is: P49327
initial amount: NaN
constant: false
boundary condition: true

metaM dump c
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
is: CHEBI:246422
is: C00365
is: HMDB01409
initial amount: NaN
initial concentration: 1.0
name: dUMP
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7004ecf3_36bb_4988_8fd0_43eb1e9c765a
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI990637_1_x
is encoded by: hsa:AI990637
boundary condition: true

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM ca2 e
name: calcium(2+)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00464
has only substance units: false
initial amount: NaN
is: CHEBI:29108
boundary condition: false
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaR LDH L
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
name: L-lactate dehydrogenase
reversible: true
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaM dudp c
is: C01346
initial concentration: 1.0
type: Species
is: HMDB01000
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP
is: CHEBI:60471
constant: false
has only substance units: false

metaR DOPAt4 2 r
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110017#
name: Dopamine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true

metaR DNDPt27m
kinetic law: MODEL1310110017#
name: dCDP transport via dTDP antiport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000269
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110017#

metaM L2aadp c
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
is: SBO:0000247
name: L-2-aminoadipate(1-)
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00510
initial concentration: 1.0
is: CHEBI:58672

http://identifiers.org/biomodels.db/MODEL1310110017#_3a6e0815_441c_45e0_b452_4a9ff4ecf0f9
boundary condition: true
name: _AI285872_1_c
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI285872
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_2b5903c1_025f_4e3a_afd7_4ae1a061622b
has only substance units: false
boundary condition: true
is encoded by: hsa:55089
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q969I6
name: SLC38A4
initial amount: NaN

metaM HC01602 c
initial concentration: 1.0
is: SBO:0000247
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
type: Species
is: CHEBI:57454
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_336e7ca9_ff25_44c0_a537_049352ed2ae5
initial amount: NaN
name: COX7A1
type: Species
is encoded by: hsa:1346
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P24310

metaR 34DHXMANDACOX
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269

metaM co2 c
is: C00011
is: HMDB01967
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:3313
name: CO2
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0
boundary condition: false
type: Species

metaM cmp c
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:60377
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: CMP
is: HMDB00095
type: Species
is: C00055

metaR r0181
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 3oddcoa m
has only substance units: false
is: HMDB03937
type: Species
constant: false
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
initial amount: NaN
boundary condition: false
is: CHEBI:27868
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

metaM lnlccoa m
has only substance units: false
is: SBO:0000247
name: linoleic coenzyme A
is: HMDB01064
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
type: Species
boundary condition: false

metaM fad m
is: C00016
type: Species
is: HMDB01248
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2017
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110017#

metaR SERDGLYexR
name: D-Serine/Glycine reversible exchange
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110017#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_22edd66b_460a_434c_b4b4_9cd8cd33d183
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55902
boundary condition: true
constant: false
is: Q5QPH3
type: Species
is: SBO:0000252
name: ACSS2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_389b4b49_d97c_4aa7_8074_86f6a42aabbb
is: Q9H0N5
is: SBO:0000252
is encoded by: hsa:84105
name: PCBD2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaM gtp n
is: CHEBI:37565
name: GTP(4-)
is: HMDB01273
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_45e67af8_8fb5_4e74_866b_3272bddb7530
initial amount: NaN
name: DCTD
boundary condition: true
initial concentration: NaN
type: Species
is: P32321
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1635
constant: false

metaM ksii core2 l
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate II (core 2-linked)
is: CHEBI:57614
is: HMDB00189
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110017#_095204f7_7d5f_4f3f_b982_340cc87789da
initial amount: NaN
is encoded by: hsa:1806
boundary condition: true
has only substance units: false
constant: false
name: DPYD
is: Q12882
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_e7e97259_d9a7_4adf_870f_476726d5c484
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _AI935189_1_m
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI935189

http://identifiers.org/biomodels.db/MODEL1310110017#_bbb396c2_9c75_41d3_9a26_6164d3ed6c7f
is encoded by: hsa:8611
is: SBO:0000252
is: G3XA95
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PPAP2A

http://identifiers.org/biomodels.db/MODEL1310110017#_0dee93c4_3ea8_468c_b7c7_1ba69f8f06a6
is encoded by: hsa:3283
boundary condition: true
initial amount: NaN
is: P14060
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: HSD3B1

metaR SERDGLNexR
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: D-Serine/Glutamine reversible exchange
is: SBO:0000185
is described by: ECO:0000304
reversible: true

metaR r0668
modifier: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.4.2.19
is: SBO:0000176
type: Reaction
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true

metaR r0932
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_383c17d7_608c_40b4_8839_ba6f828cae50
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10327
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: AKR1A1

metaM nadp x
is: HMDB00217
initial amount: NaN
boundary condition: false
is: CHEBI:58349
has only substance units: false
is: C00006
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_bf8de6ea_596e_4fc6_bbf8_cccdc25502a8
is: Q96FL9
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:79623
name: GALNT14
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM ca2 c
constant: false
name: calcium(2+)
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00464
boundary condition: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
initial amount: NaN

metaM pchol hs m
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16110
name: Phosphatidylcholine
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaM glyclt c
constant: false
is: HMDB00115
type: Species
initial concentration: 1.0
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
boundary condition: false
name: glycolate
is: SBO:0000247
initial amount: NaN

metaR r2014
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction

metaR XOL7AH2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110017#
fast: false
reversible: true

metaM retfa e
has only substance units: false
constant: false
is: HMDB00508
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol
boundary condition: false
type: Species
is: CHEBI:15963
is: SBO:0000247

metaR CHOLtg
reversible: true
fast: false
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: choline intracellular transport
product: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_7dc1a6fd_ccd3_4a25_a14a_d43d64d1225e
is encoded by: hsa:AI291895
initial amount: NaN
boundary condition: true
constant: false
name: _AI291895_1_c
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR RBFK
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: riboflavin kinase
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false
is described by: ECO:0000269

metaR r0074
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110017#
reversible: true
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false

metaR r0931
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110017#_855f18ca_c613_4928_93d9_ef99d551e03a
is encoded by: hsa:28976
has only substance units: false
initial amount: NaN
constant: false
name: ACAD9
is: Q9H845
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_7c1f4928_6929_4f5f_b3e0_8c49d65a5e21
is: P51687
constant: false
boundary condition: true
name: SUOX
initial concentration: NaN
is encoded by: hsa:6821
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_f3a88f16_9728_4e5b_9324_573a4991f1e9
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC6A8
initial concentration: NaN
is encoded by: hsa:6535
is: B4DIA3
is: SBO:0000252
constant: false

metaR r0669
reversible: false
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaR MALSO4tm
is described by: ECO:0000269
modifier: MODEL1310110017#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110017#
fast: false
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_a81af117_c066_49f6_9bb3_1493bdb47fbf
name: OGDH
is encoded by: hsa:4967
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: Q02218
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_42ed757d_d4d9_479f_ba55_fc7fc4624aad
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1337
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P12074
name: COX6A1

http://identifiers.org/biomodels.db/MODEL1310110017#_1d90a3ff_b25e_404a_adf5_b1770a4150fa
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AI926493
name: _AI926493_1_c

metaR GULN3D
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110017#
name: L-gulonate 3-dehydrogenase
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
name: intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction

metaM o2s c
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18421
constant: false
type: Species
name: superoxide
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_ff7b7012_dc71_4fb6_9434_a369cc5087c4
has only substance units: false
constant: false
is encoded by: hsa:2538
is: P35575
is: SBO:0000252
type: Species
name: G6PC
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR RE3421R
name: RE3421
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110017#

metaM nadp r
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58349

http://identifiers.org/biomodels.db/MODEL1310110017#_f5555683_8535_462e_8c6c_d8b7926e5d71
is: Q9NUB1
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:84532
initial amount: NaN
name: ACSS1

metaR r1824
name: Y+LAT2 Utilized transport
product: MODEL1310110017#
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
is described by: ECO:0000000

metaR r2085
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_e1b64e33_11ab_4089_864f_7f7a7b03c568
initial concentration: NaN
constant: false
name: GGT2
has only substance units: false
type: Species
is encoded by: hsa:728441
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM nadph m
has only substance units: false
initial amount: NaN
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
is: HMDB00221
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: CHEBI:57783
boundary condition: false
initial concentration: 1.0

metaM CE1617 r
is: HMDB01358
name: 9-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17898
has only substance units: false
is: SBO:0000247
constant: false

metaR UDPGLCter
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false
reactant: MODEL1310110017#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_a5e70a24_cbc2_4873_b073_dac354616e05
type: Species
boundary condition: true
is encoded by: hsa:AI971036
constant: false
initial amount: NaN
name: _AI971036_1_x
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_7f95122c_8897_4f93_97f5_6fa81a5b983e
name: HPD
initial concentration: NaN
is encoded by: hsa:3242
constant: false
is: SBO:0000252
initial amount: NaN
is: B3KQ63
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_dbb50952_97d9_4d64_bb44_97714c2e3a27
type: Species
boundary condition: true
initial concentration: NaN
name: GALE
is: Q14376
initial amount: NaN
is encoded by: hsa:2582
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ee3e228d_1fde_4870_918b_3a79f6128a2b
is: SBO:0000252
has only substance units: false
is: P00439
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: PAH
is encoded by: hsa:5053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_8b8a79e8_867a_4244_ab72_43dfc5bce250
is encoded by: hsa:956
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ENTPD3
type: Species
initial amount: NaN
has only substance units: false
is: O75355

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR r2013
fast: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_9d056734_d474_4192_8744_044fdcf8048d
has only substance units: false
is encoded by: hsa:3417
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O75874
constant: false
name: IDH1
initial concentration: NaN

metaR r2084
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c512ab52_342a_4de1_9950_0b1a9a5a716b
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9962
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC23A2

metaR r0789
type: Reaction
product: MODEL1310110017#
fast: false
reversible: true
modifier: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110017#

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: SBO:0000247
is: CHEBI:18421
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02168
name: superoxide
has only substance units: false

metaR r1822
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: false
modifier: MODEL1310110017#
fast: false

metaM hgentis c
type: Species
is: CHEBI:16169
constant: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: HMDB00130
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: homogentisate
initial amount: NaN
boundary condition: false

metaR r2082
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110017#
reversible: true
is: SBO:0000185
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
is: SBO:0000247
is: HMDB02329
initial amount: NaN
constant: false
type: Species
name: 3-oxolinoleoyl-CoA
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR CYSTA
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
name: cysteine transaminase
type: Reaction
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is described by: ECO:0000304
modifier: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#

metaM f1a l
is: HMDB02917
boundary condition: false
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17151

metaR SPODMx
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: superoxide dismutase, peroxisome
reactant: MODEL1310110017#
fast: false
reversible: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_718cd7c2_d9b6_4626_8ce6_d04ed946a2ac
has only substance units: false
is encoded by: hsa:3074
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: HEXB
initial concentration: NaN
is: SBO:0000252
is: P07686

metaM udpacgal l
type: Species
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: HMDB00304
has only substance units: false
is: CHEBI:57847
initial amount: NaN
is: SBO:0000247
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)

metaM fum c
is: C00122
is: CHEBI:29806
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
boundary condition: false
name: Fumarate
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00134

metaR O2Stm
fast: false
reversible: true
name: superoxide anion transport via diffusion (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_24442700_8255_424a_9ccf_1aee6ab3d45c
constant: false
is: O43678
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFA2
has only substance units: false
is encoded by: hsa:4695
boundary condition: true

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110017#

metaR SMPD4
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false
type: Reaction
name: sphingomyelinase
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110017#
fast: false

metaM duri n
has only substance units: false
constant: false
name: 2'-deoxyuridine
is: SBO:0000247
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaM ksii core4 deg2 l
is: SBO:0000247
is: CHEBI:12936
constant: false
type: Species
boundary condition: false
is: HMDB00143
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 2
initial concentration: 1.0

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR O2Stn
is: SBO:0000185
name: superoxide anion transport via diffusion (nucleus)
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true

metaM pchol hs r
is: CHEBI:16110
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_2db9d137_90b7_4c6e_8d79_1b967784c3e1
is: Q86YT5
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC13A5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:284111

metaR r1556
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_1dffcfce_8fbf_4db1_a4fa_c5c68cc8938d
is: SBO:0000252
name: ALDH3B1
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: P43353
is encoded by: hsa:221

metaM pnto R c
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:7916
name: (R)-Pantothenate
is: HMDB00210

metaR RE0512M
is: SBO:0000176
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r0604
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reversible: false
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_4f940f79_fad9_41c2_9736_54ba728f065a
constant: false
has only substance units: false
is: Q9NQU1
name: SLC26A6
is encoded by: hsa:65010
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR ACNAMlt
name: N-acetylneuraminate transport into lysososme
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_1f3ee83a_9591_4753_87da_8c73a0e89fa6
is: O75355
initial amount: NaN
is: SBO:0000252
name: ENTPD3
constant: false
has only substance units: false
type: Species
is encoded by: hsa:956
boundary condition: true
initial concentration: NaN

metaM b2coa m
name: crotonoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: HMDB02009
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57332

http://identifiers.org/biomodels.db/MODEL1310110017#_a5dfd2a2_868c_440b_b677_5b114f8a4ded
type: Species
initial amount: NaN
name: RDH10
is: SBO:0000252
has only substance units: false
is encoded by: hsa:157506
boundary condition: true
initial concentration: NaN
constant: false
is: Q8IZV5

http://identifiers.org/biomodels.db/MODEL1310110017#_54d38ac7_54fe_4e57_8a32_12e332c25747
constant: false
initial amount: NaN
is encoded by: hsa:3614
initial concentration: NaN
type: Species
name: IMPDH1
has only substance units: false
boundary condition: true
is: C9JV30
is: SBO:0000252

metaR RE0944E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000176
name: RE0944
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#

metaM ksii core4 deg3 l
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
type: Species
is: HMDB00143
boundary condition: false
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:12936

metaR RE2651R
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110017#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
name: RE2651
is: SBO:0000176

metaM fad x
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
boundary condition: false
initial amount: NaN
constant: false

metaM CE2434 m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
type: Species
is: C01936
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

metaR RPI
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
modifier: MODEL1310110017#
name: ribose-5-phosphate isomerase
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4783c678_d1be_4e3c_81dc_79d8e7bf74b4
is: SBO:0000252
name: HMGCS1
constant: false
is: Q01581
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:3157
type: Species
has only substance units: false

metaM C05280 m
initial concentration: 1.0
type: Species
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA
boundary condition: false
initial amount: NaN
is: CHEBI:28002
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: SBO:0000247
is: HMDB03952
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_2c8b61c4_a5ec_4f78_9747_bb060b3ff5d9
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3290
initial amount: NaN
name: HSD11B1
constant: false
has only substance units: false

metaM pnto R e
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:7916

metaR r2360
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110017#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false

metaR GLUPROASCT1
modifier: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
is described by: ECO:0000134
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
fast: false
reversible: false
reactant: MODEL1310110017#
name: glutamate intake by system ASCT-1 transporter

http://identifiers.org/biomodels.db/MODEL1310110017#_750cc177_4b00_480d_849b_03727a712800
boundary condition: true
is: P54868
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:3158
has only substance units: false
is: SBO:0000252
type: Species
name: HMGCS2

metaR r0450
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_5787210f_2b65_42fd_a433_e2c0caec0ab3
boundary condition: true
is encoded by: hsa:83594
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9BQG2
has only substance units: false
name: NUDT12
type: Species

metaM udp c
is: HMDB00295
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP
constant: false
is: C00015
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM cit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
is: C00158
name: Citrate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00094
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaM 4mop m
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: HMDB00695
boundary condition: false
initial amount: NaN
has only substance units: false
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
is: CHEBI:17865

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction

metaM 2mb2coa m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57337
name: 2-methylcrotonoyl-CoA(4-)
constant: false
is: HMDB02054
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345

metaR r1557
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f171fe24_6dc2_4ec9_8662_1536968ea170
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: AK3
is encoded by: hsa:50808
boundary condition: true
is: E7ET30
initial concentration: NaN
is: SBO:0000252

metaR r0451
product: MODEL1310110017#
reactant: MODEL1310110017#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110017#

metaM dhcholestanate c
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16577
initial concentration: 1.0
boundary condition: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
initial amount: NaN

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaM hLkynr c
type: Species
constant: false
has only substance units: false
is: HMDB11631
name: 3-hydroxy-L-kynurenine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17380

http://identifiers.org/biomodels.db/MODEL1310110017#_8da1b641_5d4b_48aa_9194_c06f1373df74
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4842
constant: false
is: B4DG68
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: NOS1

metaM o2 x
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00007
type: Species
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
is: HMDB01377
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR r1629
kinetic law: MODEL1310110017#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR GLXtp
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true
type: Reaction
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000000

metaR FUMtm
fast: false
reversible: true
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
name: fumarate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f67ab73d_12f7_48e2_b6d3_2fb33ee93721
is encoded by: hsa:3030
is: SBO:0000252
name: HADHA
constant: false
boundary condition: true
is: E9KL44
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_23fb2d55_6e80_4683_848d_d499b86780f1
is encoded by: hsa:377841
name: ENTPD8
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: Q5MY95
type: Species
is: SBO:0000252

metaM 4aphdob c
is: HMDB00978
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: CHEBI:58147
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_2cd562a8_bd27_4dd6_8249_cbcfb4d0cd69
has only substance units: false
name: LDHA
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3939
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P00338

metaM uri e
initial amount: NaN
type: Species
boundary condition: false
name: Uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16704
is: C00299
is: HMDB00296
initial concentration: 1.0

metaR r0830
reversible: true
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
fast: false
reactant: MODEL1310110017#

metaR RPE
name: ribulose 5-phosphate 3-epimerase
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/5.1.3.1
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false

metaM retinol cis 11 e
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
name: 11-cis-retinol
has only substance units: false
constant: false
is: HMDB06216
initial concentration: 1.0
is: CHEBI:16302

metaM tsul c
name: thiosulfate(2-)
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00257
initial amount: NaN
is: CHEBI:16094

metaM guln r
is: HMDB03290
boundary condition: false
is: SBO:0000247
name: L-gulonate
has only substance units: false
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
type: Species
is: CHEBI:13115
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_e2372afc_b602_40b0_83a2_4e947449e643
is: SBO:0000252
name: _AA278423_1_m
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AA278423
initial amount: NaN
initial concentration: NaN
type: Species

metaR r1626
reversible: true
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR ABTD
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
is described by: ECO:0000000
name: L-arabinitol 4-dehydrogenase
reversible: true
is: SBO:0000176

metaR NOt
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
type: Reaction
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is described by: ECO:0000000
reactant: MODEL1310110017#

metaR r0672
fast: false
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_d2fe9a82_66ff_442d_a682_85cd2fb15e9c
type: Species
is: SBO:0000252
initial amount: NaN
is: Q05C14
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2352
name: FOLR3

metaR G6PPer
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110017#
fast: false
is: SBO:0000176
name: glucose-6-phosphate phosphatase, edoplasmic reticular
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.9
modifier: MODEL1310110017#
reversible: false
type: Reaction

metaR RE1525M
name: RE1525
fast: false
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
modifier: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#

metaR r1559
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#

metaR r1627
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#

metaR DNDPt17m
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110017#
reversible: false
name: dUDP transport via dCDP antiport
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r1010
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
name: Postulated transport reaction

metaR r0726
product: MODEL1310110017#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction

metaM CE2705 n
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB02281
name: quinonoid dihydrobiopterin
initial concentration: 1.0
is: CHEBI:15374
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705

http://identifiers.org/biomodels.db/MODEL1310110017#_0279c8ca_e65f_4935_8263_2c98fc767d0a
is: SBO:0000252
type: Species
is encoded by: hsa:570
boundary condition: true
initial amount: NaN
constant: false
is: Q14032
initial concentration: NaN
has only substance units: false
name: BAAT

metaM udp g
name: UDP(3-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58223
is: SBO:0000247
type: Species
is: HMDB00295

http://identifiers.org/biomodels.db/MODEL1310110017#_56e35dbc_539a_4bd9_91d5_515ae9c22721
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:3417
name: IDH1
is: O75874
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1624
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110017#
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
fast: false
type: Reaction

metaM retinol cis 11 c
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: 11-cis-retinol
initial concentration: 1.0
constant: false
is: HMDB06216

metaR DCYTt
type: Reaction
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
name: deoxycytidine transport via diffusion
fast: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#

metaR GLXtm
name: glyoxylate transport, mitochondrial
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
product: MODEL1310110017#

metaM maltpt e
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
has only substance units: false
name: maltopentaose
boundary condition: false
type: Species
is: HMDB01296
is: C02052
constant: false
is: SBO:0000247

metaM glyc R c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
boundary condition: false
has only substance units: false
is: CHEBI:16659
name: D-glycerate

http://identifiers.org/biomodels.db/MODEL1310110017#_03207fcd_c88d_4335_b941_d6f14c6123a6
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: P30048
initial amount: NaN
name: PRDX3
is encoded by: hsa:10935

metaR 3MOX4HOXPGALDOX
reactant: MODEL1310110017#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
reversible: false
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_be47ec94_91bd_44bb_b557_798f13a8f020
initial concentration: NaN
is: SBO:0000252
name: NDUFB1
initial amount: NaN
constant: false
is encoded by: hsa:4707
boundary condition: true
is: O75438
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_05d76415_9063_429d_9774_2899d9ed1275
is: Q5QPH3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55902
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ACSS2
is: SBO:0000252

metaR SPODMe
is: SBO:0000176
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
fast: false
name: superoxide dismutase, extracellular
reversible: false
reactant: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR

metaR Q10H2e
reversible: true
fast: false
product: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
name: transport of ubiquinol into lymph
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

http://identifiers.org/biomodels.db/MODEL1310110017#_f2755215_5359_49a3_ba0e_9affedf9ebe7
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: IDH3B
is: O43837
type: Species
constant: false
is encoded by: hsa:3420
boundary condition: true
initial concentration: NaN

metaR MANt4
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
name: D-mannose transport via sodium cotransport
modifier: MODEL1310110017#

metaM 1pipdn2c x
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01084
is: CHEBI:16187
is: SBO:0000247
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
boundary condition: false
has only substance units: false
constant: false
name: 1-piperideine-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110017#_2580b3f4_1c7f_491e_87c1_4cdda84af2f9
is: SBO:0000252
is encoded by: hsa:D87002
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: _D87002_1_m

metaM sT antigen g
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16565
initial amount: NaN
name: sialyl-T antigen
boundary condition: false
type: Species
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1

metaR r1625
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110017#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM thbpt4acam n
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
type: Species
constant: false
is: SBO:0000247
is: HMDB02281
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin

metaR r0728
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110017#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110017#
fast: false
type: Reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_866818f2_deef_45b1_bdc1_54f589b423fc
initial amount: NaN
constant: false
is encoded by: hsa:211
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: P13196
name: ALAS1
initial concentration: NaN

metaM gly x
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: HMDB00123
boundary condition: false
is: SBO:0000247
has only substance units: false
name: glycine
constant: false
is: CHEBI:15428
initial amount: NaN

metaM dc2coa m
name: trans-Dec-2-enoyl-CoA
constant: false
is: CHEBI:61406
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#

metaR FRDPtcr
product: MODEL1310110017#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reversible: true
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR PIter
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000212
type: Reaction
reversible: true
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110017#
fast: false
name: phosphate transport, endoplasmic reticulum
kinetic law: MODEL1310110017#

metaR r2367
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
name: Organic anion transporter 5 Utilized transport

metaM cit c
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: SBO:0000247
is: HMDB00094
is: C00158
is: CHEBI:16947
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaM pmtcoa x
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
initial amount: NaN
is: CHEBI:57379
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c61ccd74_9181_4792_a9e2_637b1c6ac13a
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: DEGS1
is encoded by: hsa:8560
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O15121

http://identifiers.org/biomodels.db/MODEL1310110017#_87329714_100e_41fc_b58f_527ff604a6d1
type: Species
boundary condition: true
is encoded by: hsa:R06874
is: SBO:0000252
constant: false
name: _R06874_1_r
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM gly m
constant: false
is: C00037
initial concentration: 1.0
is: SBO:0000247
is: HMDB00123
is: CHEBI:15428
has only substance units: false
name: Glycine
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
boundary condition: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_8f947ebf_2161_4542_9345_66a778c2e04e
initial amount: NaN
initial concentration: NaN
name: ALDH3B2
is encoded by: hsa:222
is: P48448
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f79ae82c_3f64_4964_b0f4_3639c49fcd4a
is: Q16773
is encoded by: hsa:883
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: CCBL1
initial concentration: NaN

metaM 4mop c
is: HMDB00695
initial concentration: 1.0
is: CHEBI:17865
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaR r0835
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110017#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_d021022e_b3b0_4b21_9cca_77c15cf4ffb6
initial concentration: NaN
is encoded by: hsa:2030
type: Species
is: SBO:0000252
is: Q99808
initial amount: NaN
name: SLC29A1
constant: false
boundary condition: true
has only substance units: false

metaR r2368
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_42577c1e_abb3_40a8_a22a_41d17f2acb4a
boundary condition: true
is encoded by: hsa:8871
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SYNJ2
initial amount: NaN
type: Species
constant: false
is: O15056

metaM tdchola c
initial amount: NaN
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
is: CHEBI:9407
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: taurochenodeoxycholate
has only substance units: false

metaM pgp hs c
type: Species
is: CHEBI:57406
initial amount: NaN
notes: FORMULA: C6H11O9P2FULLRCO2FULLR2CO2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC02095
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01403
is: SBO:0000247
has only substance units: false
name: phosphatidyl glycerol phosphate

http://identifiers.org/biomodels.db/MODEL1310110017#_16eff39e_c258_48fb_b95e_65b9b03282bb
has only substance units: false
type: Species
name: PYCR1
is encoded by: hsa:5831
is: A6NFM2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR ADKd
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
reactant: MODEL1310110017#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110017#
reversible: true
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110017#
fast: false

metaM o2 r
is: HMDB01377
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:15379
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM frdp x
is: HMDB00961
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: farnesyl pyrophosphate(3-)
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:175763

metaM HC02204 c
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27624
initial amount: NaN
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species

metaR r0722
reversible: true
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

http://identifiers.org/biomodels.db/MODEL1310110017#_9e031a35_168a_4f65_af24_ca3fc7ad29ef
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q1EHB4
is: SBO:0000252
name: SLC5A12
initial concentration: NaN
constant: false
is encoded by: hsa:159963

metaR PROSTGE2t2
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110017#
name: prostaglandin uniport
is: SBO:0000185
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_85dc53e1_7d55_4f30_940f_0bc94ee34358
has only substance units: false
initial concentration: NaN
name: SKIV2L2
is: Q3MHC9
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:23517
initial amount: NaN

metaM thbpt4acam c
is: SBO:0000247
is: HMDB02281
is: CHEBI:15374
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0

metaR TRIODTHYt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000185
name: T3 transport via facilitated diffusion
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
fast: false

metaR GLCt4
kinetic law: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
fast: false
name: glucose transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110017#
is: SBO:0000185

metaM 34dhoxmand c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01866
is: CHEBI:27637
initial concentration: 1.0
name: 3,4-Dihydroxymandelate

http://identifiers.org/biomodels.db/MODEL1310110017#_c0811b3d_6192_4356_8fa4_d5458117184b
initial concentration: NaN
has only substance units: false
is encoded by: hsa:220
boundary condition: true
initial amount: NaN
is: P47895
is: SBO:0000252
name: ALDH1A3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_284382c9_7642_41a4_b194_1095d32837f6
constant: false
has only substance units: false
is: Q5JT09
name: UCK1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:83549
type: Species
boundary condition: true
is: SBO:0000252

metaM cit e
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
is: SBO:0000247
boundary condition: false
name: citrate(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00094
is: CHEBI:16947

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR 3MOBt2im
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction

metaR r2473
product: MODEL1310110017#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.4.5

metaR r2365
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
reversible: true
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_691cbcfa_9c65_4b1f_b333_510919c91772
type: Species
is encoded by: hsa:2678
constant: false
name: GGT1
is: SBO:0000252
is: P19440
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR RE2660C
is described by: ECO:0000000
type: Reaction
name: RE2660
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110017#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_b9441f0c_3180_4eab_a347_262f922ef1a0
name: SDHA
initial concentration: NaN
is encoded by: hsa:6389
constant: false
initial amount: NaN
is: P31040
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_6ab20010_22ab_45bc_8e2c_1f77b3d39875
is: Q8TF71
initial amount: NaN
has only substance units: false
is encoded by: hsa:117247
name: SLC16A10
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_1d20f566_1745_4fb3_a57e_d980136dc490
is encoded by: hsa:6520
is encoded by: hsa:56301
is: SBO:0000297
has only substance units: false
has part: P08195
has part: Q9NS82
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: SLC7A10:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110017#_616ff1a6_eb0d_4339_ab1e_8e1e0b2b52bc
type: Species
initial concentration: NaN
is: G3V4L5
is encoded by: hsa:89874
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC25A21
constant: false
initial amount: NaN

metaM uri c
is: SBO:0000247
constant: false
is: C00299
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
boundary condition: false
initial concentration: 1.0
name: Uridine
initial amount: NaN
is: HMDB00296
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_b277af08_9da2_46a7_8ee1_aba694e0c35b
is: D9HTE9
is encoded by: hsa:6576
boundary condition: true
has only substance units: false
name: SLC25A1
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_13b3cc87_5c91_4263_9381_5404a17790a9
initial amount: NaN
is encoded by: hsa:11001
initial concentration: NaN
type: Species
is: SBO:0000252
is: O14975
constant: false
name: SLC27A2
has only substance units: false
boundary condition: true

metaR r2366
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110017#

metaR NS26T2g
is version of: http://identifiers.org/ec-code/2.4.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110017#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

http://identifiers.org/biomodels.db/MODEL1310110017#_993909ed_3432_48aa_8f96_4b2ceab3f99f
is: SBO:0000252
is encoded by: hsa:4708
type: Species
is: H7C5B8
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFB2
initial amount: NaN
boundary condition: true

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
reactant: MODEL1310110017#

metaM tdchola e
boundary condition: false
is: CHEBI:9407
is: HMDB00951
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: taurochenodeoxycholate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaR NDPK3m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000254
kinetic law: MODEL1310110017#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
fast: false

metaR r0670
reactant: MODEL1310110017#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110017#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_83df1764_86cc_41ec_8b77_ef51048b34f7
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6571
has only substance units: false
is: SBO:0000252
is: Q05940
name: SLC18A2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_503d64eb_bc73_48be_898e_528b6a64f3d9
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: B4DR31
initial amount: NaN
is encoded by: hsa:1808
name: DPYSL2
boundary condition: true
constant: false

metaR r2506
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_a4b722f7_6fab_44ac_b057_9a75f1ddd40d
is: O15382
initial concentration: NaN
name: BCAT2
is encoded by: hsa:587
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR r2128
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
reversible: true
is described by: ECO:0000000
fast: false

metaR DNDPt39m
fast: false
modifier: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
name: dUTP transport via dGDP antiport

http://identifiers.org/biomodels.db/MODEL1310110017#_61525f91_3ab8_4a8f_abe2_57242a777dd9
is encoded by: hsa:65985
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: AACS
is: Q86V21
type: Species

metaR r2363
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110017#
name: Organic anion transporter 5 Utilized transport

metaR CYSGLYexR
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
is: SBO:0000185
reversible: true
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
product: MODEL1310110017#
type: Reaction

metaM udp n
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
type: Species
is: HMDB00295
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
initial amount: NaN
is: SBO:0000247

metaR CMPACNAtg
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110017#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110017#
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185

metaR r0838
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110017#
name: Free diffusion

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_18d16825_ac5d_4b08_952e_12c6b1e51c91
initial concentration: NaN
type: Species
name: LDHB
is: P07195
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3945
initial amount: NaN
has only substance units: false

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
kinetic law: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_f9889040_6b0f_4d19_8434_369ae7b6ea68
boundary condition: true
is: SBO:0000252
name: CA4
constant: false
initial concentration: NaN
is: Q6FHI7
has only substance units: false
is encoded by: hsa:762
type: Species
initial amount: NaN

metaM HC01434 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
constant: false
is: CHEBI:58931
initial amount: NaN

metaM nh4 x
is: SBO:0000247
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
is: C01342
initial amount: NaN
boundary condition: false
is: CHEBI:28938
constant: false
initial concentration: 1.0
name: Ammonium
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_fe25d9a2_7070_4dd5_9cdb_7b381aa33a43
is encoded by: hsa:38
has only substance units: false
boundary condition: true
name: ACAT1
is: P24752
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR RE1448N
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000000
name: RE1448
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reactant: MODEL1310110017#
is: SBO:0000176

metaR r1552
reactant: MODEL1310110017#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_2ecf2c04_fc38_4555_8ee6_edfbe5dae98b
type: Species
is: SBO:0000252
is encoded by: hsa:6531
is: Q01959
boundary condition: true
constant: false
name: SLC6A3
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM ser D e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
is: HMDB03406
name: D-serine
constant: false
is: SBO:0000247
is: CHEBI:16523
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_204d0656_3ba3_4410_bea3_aa84bef75d65
is encoded by: hsa:AL038231
boundary condition: true
constant: false
has only substance units: false
name: _AL038231_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_2780dd23_6c0a_4161_a39f_6c54c424449a
boundary condition: true
initial amount: NaN
name: AQP8
is encoded by: hsa:343
constant: false
initial concentration: NaN
is: O94778
is: SBO:0000252
has only substance units: false
type: Species

metaR r2127
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM o2 n
type: Species
is: HMDB01377
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: dioxygen
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:15379

metaR 2HBt2
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
modifier: MODEL1310110017#
reversible: true
type: Reaction
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_f563a983_7e0b_412b_98f3_9102e07c58d6
initial amount: NaN
is: Q99624
name: SLC38A3
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10991
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_7e17f009_9c4f_4e75_accb_2af47640b6ed
boundary condition: true
has only substance units: false
name: PRDX1
initial concentration: NaN
is encoded by: hsa:5052
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM HC00319 m
type: Species
name: Malonate
constant: false
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:30794
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_b20b614a_3689_41d7_8419_ea3f66f3e162
type: Species
initial amount: NaN
is encoded by: hsa:FLJ44968
is: SBO:0000252
name: _FLJ44968_1_m
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM alpam m
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06239
initial amount: NaN
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
name: S-aminomethyldihydrolipoamide

http://identifiers.org/biomodels.db/MODEL1310110017#_85550d61_1a30_4fdc_bb6d_f79e2f2d7356
initial concentration: NaN
is: O14734
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10005
type: Species
constant: false
name: ACOT8

metaR r0839
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ba5a1295_4f24_4a6c_9137_906c7f9f191c
is encoded by: hsa:56848
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9NRA0
constant: false
initial concentration: NaN
name: SPHK2
has only substance units: false
type: Species

metaR r1551
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false

metaM g1p e
has only substance units: false
name: alpha-D-glucose 1-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58601
is: SBO:0000247
is: HMDB01586

metaM o2 m
boundary condition: false
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01377
type: Species
is: CHEBI:15379

metaM udp l
has only substance units: false
is: HMDB00295
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
constant: false
name: UDP(3-)
type: Species
initial concentration: 1.0
initial amount: NaN

metaM tsul m
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16094
is: HMDB00257
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_ec56c98d_616d_489f_8e7b_e89b67559269
is encoded by: hsa:4723
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: E5KNH5
type: Species
initial amount: NaN
constant: false
name: NDUFV1

http://identifiers.org/biomodels.db/MODEL1310110017#_ac38634d_90e8_4c96_8be1_b52bbb104aab
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10166
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: Q9Y619
name: SLC25A15
initial amount: NaN

metaR HMGCOASim
product: MODEL1310110017#
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
modifier: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
kinetic law: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.10

metaR ASPTA
modifier: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
name: aspartate transaminase
product: MODEL1310110017#

metaR DHFR
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
reactant: MODEL1310110017#
fast: false
name: dihydrofolate reductase
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110017#_c9ac95b0_90ef_40d4_801c_536417a8e09d
initial amount: NaN
is encoded by: hsa:1962
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: EHHADH
is: Q9NY65
is: SBO:0000252

metaR DCTPtn
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dCTP diffusion in nucleus
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000000

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR r0522
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
modifier: MODEL1310110017#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
fast: false
reversible: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaR r1554
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_7538e77d_52ce_4bd8_a14e_ef2b94aa1348
type: Species
has only substance units: false
is: P32019
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:3633
name: INPP5B
initial amount: NaN

metaR SPODMn
name: superoxide dismutase, nuclear
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#

metaR GUAt
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
product: MODEL1310110017#
name: Guanine transport
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_141be35f_6088_4608_a3fb_98b0c36931b8
name: RBAK
is encoded by: hsa:57786
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9NYW8

http://identifiers.org/biomodels.db/MODEL1310110017#_0c5f15e0_0d71_4864_a5af_1d71f766f1ce
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:2747
is: P49448
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: GLUD2

metaM HC02204 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
has only substance units: false
is: CHEBI:27624
constant: false
initial amount: NaN
type: Species
name: prostaglandin-b1
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_9020fef9_963b_4e07_8f0f_e5c7873f832e
constant: false
name: _AV717590_1_m
initial concentration: NaN
is encoded by: hsa:AV717590
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR r2362
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_cf435d7e_d05a_462a_b075_a82eae9eb437
boundary condition: true
type: Species
is encoded by: hsa:2222
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: P37268
has only substance units: false
name: FDFT1

http://identifiers.org/biomodels.db/MODEL1310110017#_11416616_34d4_4a06_8e28_12188ca61bc2
constant: false
type: Species
is encoded by: hsa:83549
is: Q5JT09
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: UCK1
is: SBO:0000252
has only substance units: false

metaR r2129
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110017#

metaR r0603
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
modifier: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:

metaR D3AIBTm
fast: false
is: SBO:0000176
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reversible: true
type: Reaction

metaR GLCMter
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
name: glucose transport via membrane vesicle
reactant: MODEL1310110017#
fast: false
reversible: false
type: Reaction

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NDPK9n
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
reactant: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: true

metaM pmtcoa r
is: C00154
constant: false
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaM glyc e
initial amount: NaN
boundary condition: false
is: C00116
is: HMDB00131
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17754
name: Glycerol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_31ec4f9b_9a60_492d_8586_131a6a027356
initial concentration: NaN
is encoded by: hsa:84532
type: Species
is: SBO:0000252
name: ACSS1
is: Q9NUB1
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR r0523
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110017#
type: Reaction
is: SBO:0000176
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110017#_9a8dafa6_1c6d_42d9_a6c6_5cd4e0a39401
name: SOD1
is: SBO:0000252
type: Species
is encoded by: hsa:6647
constant: false
initial amount: NaN
boundary condition: true
is: P00441
initial concentration: NaN
has only substance units: false

metaR r0940
fast: false
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110017#
name: Free diffusion
product: MODEL1310110017#
reversible: true
is: SBO:0000185

metaM Sfglutth c
is: SBO:0000247
is: HMDB01550
boundary condition: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
type: Species
is: CHEBI:57688
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaR r0196
fast: false
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_92463d11_269d_4ec7_bde6_6b498626a5cb
name: _AA177072_1_c
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110017#_24cc1675_ed5a_4527_9ce9_698b126a6a2e
name: PRDX2
is encoded by: hsa:7001
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P32119
type: Species

metaR CHATn
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
name: Choline O-acetyltransferase
fast: false
product: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110017#

metaR H2Otly
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
name: H2O transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110017#_08803c83_94c0_4fa2_8a6f_0c8694cb6bcd
name: COX7C
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1350
boundary condition: true
initial concentration: NaN
is: P15954
initial amount: NaN
constant: false

metaM gly e
name: Glycine
initial concentration: 1.0
is: C00037
constant: false
is: HMDB00123
initial amount: NaN
is: CHEBI:3339
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_5d85da27_79f9_4ac6_8842_0d68dfa94502
is encoded by: hsa:6553
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9NSW9
type: Species
boundary condition: true
constant: false
name: SLC9A5

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
is: C01936
is: SBO:0000247
constant: false
has only substance units: false
name: maltoheptaose
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM 3hbcoa m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (S)-3-hydroxybutanoyl-CoA(4-)
boundary condition: false
constant: false
is: CHEBI:57316
type: Species
is: HMDB01166
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

metaM prostge2 c
is: HMDB01220
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN
boundary condition: false
is: CHEBI:606564
name: prostaglandin E2(1-)
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM sphings c
name: sphingosine(1+)
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57756
type: Species
is: HMDB00252
boundary condition: false
has only substance units: false
constant: false

metaR r1116
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110017#_5fe5d0ba_f800_4369_9b6e_984ca9c0a98a
is encoded by: hsa:4694
type: Species
initial concentration: NaN
is: Q6IBB5
has only substance units: false
is: SBO:0000252
name: NDUFA1
constant: false
initial amount: NaN
boundary condition: true

metaM fadh2 c
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
is: SBO:0000247
name: FADH2(2-)
is: CHEBI:58307
has only substance units: false
type: Species
is: HMDB01197
initial amount: NaN
constant: false
initial concentration: 1.0

metaR RDH2a
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
name: retinol dehydrogenase (9-cis,NADPH)
fast: false
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110017#

metaR ASNS1
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
reactant: MODEL1310110017#
name: asparagine synthase (glutamine-hydrolysing)
is: SBO:0000176
product: MODEL1310110017#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.3.5.4
modifier: MODEL1310110017#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_462c4f0a_4f2c_4625_8ce1_92f1721d43da
type: Species
name: CHKB
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9Y259
is encoded by: hsa:1120
initial amount: NaN

metaM acald m
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: acetaldehyde
is: HMDB00990
initial amount: NaN
is: CHEBI:15343
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM glyc c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
has only substance units: false
is: SBO:0000247
constant: false
name: Glycerol
is: CHEBI:17754
type: Species

metaM ppi e
constant: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:33019
name: Diphosphate
boundary condition: false
is: HMDB00250

metaR r0942
type: Reaction
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
name: cholesterol precursor intracellular transport
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true

metaM lnlncg c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
type: Species
is: CHEBI:32391
name: gamma-linolenate

metaR SBT Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
name: D-sorbitol transport, extracellular
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110017#

metaM dgdp m
is: SBO:0000247
is: HMDB00960
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58595

metaR r1117
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
product: MODEL1310110017#

metaM frdp r
is: CHEBI:175763
name: Farnesyl diphosphate
is: C00448
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB00961
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
is: SBO:0000247

metaR GLXO1
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
reactant: MODEL1310110017#
is: SBO:0000176
name: glyoxylate oxidase
fast: false
is described by: ECO:0000269
product: MODEL1310110017#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c002417b_6498_4e9a_b8aa_444c91ce85ed
is: Q6IA69
initial concentration: NaN
type: Species
is encoded by: hsa:55191
constant: false
initial amount: NaN
is: SBO:0000252
name: NADSYN1
has only substance units: false
boundary condition: true

metaR r2137
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is described by: ECO:0000000

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR CLHCO3tex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110017#
name: chloride transport via bicarbonate countertransport (2:1)
product: MODEL1310110017#
reversible: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
fast: false

metaM gly c
initial concentration: 1.0
is: SBO:0000247
is: C00037
constant: false
is: HMDB00123
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:3339
name: Glycine

http://identifiers.org/biomodels.db/MODEL1310110017#_b7e0bc5f_4542_479e_87c1_05145dccfd5d
name: GLUD1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: E9KL48
is encoded by: hsa:2746
type: Species

metaM CE5854 e
is: SBO:0000247
is: CHEBI:27485
type: Species
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02710
name: gama-CEHC-glucuronide

http://identifiers.org/biomodels.db/MODEL1310110017#_a0ad208c_333f_4c15_8649_f4d433a20488
boundary condition: true
is: SBO:0000252
name: _728226_1_m
type: Species
is encoded by: hsa:728226
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR CEPTC
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.2
fast: false
reversible: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: choline phosphotransferase
type: Reaction

metaM sql r
constant: false
is: HMDB00256
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:15440
boundary condition: false
initial amount: NaN
type: Species

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110017#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110017#
reversible: false
name: Beta oxidation of med/long chain fatty acid
modifier: MODEL1310110017#
is described by: ECO:0000269
kinetic law: MODEL1310110017#

metaM prostge2 e
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
is: CHEBI:606564
boundary condition: false
type: Species
initial concentration: 1.0
name: prostaglandin E2(1-)
is: HMDB01220
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_532c38ad_6656_4bf2_863d_c335e3941304
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA532636
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: _AA532636_1_m

metaM dgdp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial concentration: 1.0
is: HMDB00960
type: Species
name: dGDP(2-)
is: SBO:0000247
is: CHEBI:58595
has only substance units: false
boundary condition: false
initial amount: NaN

metaM akg m
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: C00026
name: 2-Oxoglutarate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16810
constant: false
is: HMDB00208
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_fe080eb1_1eda_4932_a564_efbf1f163a7c
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
type: Species
initial amount: NaN
is: Q6LEN6
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000134
name: D-proline transport, extracellular
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_33c76e91_449d_4622_a0be_3cb2dd3c0a54
initial concentration: NaN
type: Species
boundary condition: true
name: CA1
is: P00915
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:759

metaM pan4p c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01416
boundary condition: false
is: CHEBI:47942
name: Pantetheine 4'-phosphate
type: Species
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
is: C01134

http://identifiers.org/biomodels.db/MODEL1310110017#_d680fcdf_6468_4fb5_9e8a_f8a8ca103ffa
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3033
has only substance units: false
boundary condition: true
is: Q16836
name: HADH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_b55b13cd_bca1_4314_8bdf_937323895324
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9P0J0
initial amount: NaN
is encoded by: hsa:51079
has only substance units: false
constant: false
name: NDUFA13
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_8275697b_973f_49ec_879d_ad7698a8f856
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: HGD
initial concentration: NaN
is encoded by: hsa:3081
constant: false
initial amount: NaN
is: Q93099

http://identifiers.org/biomodels.db/MODEL1310110017#_a1a564ef_02db_4c48_a612_ce44f8fd69b3
is: SBO:0000252
is: Q53HE2
initial concentration: NaN
is encoded by: hsa:7167
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: TPI1
boundary condition: true

metaR R group phosphotase 1
kinetic law: MODEL1310110017#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110017#
name: R group phosphotase 1
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_a32f2fd2_345c_4e51_858e_818eb866590f
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55350
constant: false
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110017#_80b27718_4fdd_4373_8038_95d5034a9eb2
initial amount: NaN
is: P36269
type: Species
is encoded by: hsa:2687
initial concentration: NaN
is: SBO:0000252
constant: false
name: GGT5
has only substance units: false
boundary condition: true

metaR r2508
kinetic law: MODEL1310110017#
fast: false
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction

metaM o2 e
has only substance units: false
is: HMDB01377
is: CHEBI:15379
type: Species
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110017#_2e760629_7e67_4ec9_99cb_46d5516194cc
type: Species
boundary condition: true
initial amount: NaN
name: _AA614647_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA614647
constant: false

metaR XYLTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#
name: Xylitol transport via passive diffusion
reversible: true
is described by: ECO:0000000
product: MODEL1310110017#
type: Reaction

metaM dsT antigen g
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: disialyl-T antigen
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: HMDB01440
is: SBO:0000247
is: CHEBI:16497

metaM pail hs n
constant: false
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR CYTK4n
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (dCMP,GTP),nuclear
kinetic law: MODEL1310110017#
fast: false

metaM HC00695 m
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
name: S-Succinyldihydrolipoamide
is: CHEBI:17432
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r2131
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
fast: false
product: MODEL1310110017#

metaR r0527
is: SBO:0000176
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reversible: true
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_57c12b19_8990_4753_a70d_c0caf99e501f
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1339
name: COX6A2
constant: false
has only substance units: false
is: Q02221

http://identifiers.org/biomodels.db/MODEL1310110017#_82954a11_dace_48b3_8c2c_f422168e3d4e
initial concentration: NaN
constant: false
has only substance units: false
has part: P50213
name: IDH3A:IDH3B:IDH3G
has part: E9PDD5
type: Species
boundary condition: true
is encoded by: hsa:3419
is encoded by: hsa:3420
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:3421

metaR r2507
name: Utilized transport
reversible: true
product: MODEL1310110017#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction

metaM h2o c
is: HMDB02111
is: SBO:0000247
boundary condition: false
name: H2O
type: Species
is: C00001
is: CHEBI:3303
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0

metaM urate c
is: CHEBI:17775
is: HMDB00289
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
constant: false
initial concentration: 1.0
initial amount: NaN
name: Urate

metaR PGLer
reactant: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110017#
name: 6-phosphogluconolactonase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
type: Reaction
product: MODEL1310110017#
reversible: false

metaR LYStip
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
name: L-lysine transport, peroxisomal (irreversible)
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
product: MODEL1310110017#
reactant: MODEL1310110017#

metaM ppi m
is: C00013
name: Diphosphate
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:33019
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM asn L c
has only substance units: false
initial amount: NaN
name: L-asparagine
initial concentration: 1.0
type: Species
constant: false
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
is: SBO:0000247
boundary condition: false

metaM arg L e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
name: L-argininium(1+)
is: HMDB00517
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:32682

metaM na1 c
boundary condition: false
constant: false
is: SBO:0000247
name: Sodium
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:4541
is: HMDB00588
is: C01330

metaM pan4p e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01416
is: CHEBI:47942
constant: false
boundary condition: false
name: Pantetheine 4'-phosphate
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2

metaR r2359
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110017#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2132
reactant: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000

metaM o2 c
is: C00007
name: O2
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_6eef6287_7973_4317_be41_488805a16deb
name: NDUFA5
is: SBO:0000252
is encoded by: hsa:4698
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q16718
boundary condition: true

metaM guln c
is: CHEBI:13115
name: L-gulonate
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB03290
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaR r1985
fast: false
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reversible: false
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport

metaR r1400
fast: false
is described by: ECO:0000000
name: Active transport
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction

metaR PRODt2r
name: D-proline reversible transport via proton symport
type: Reaction
is described by: ECO:0000304
product: MODEL1310110017#
fast: false
modifier: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_805dc30b_5552_4c1f_8d46_8c51a88219fa
is: B2R6S5
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51727
name: CMPK1

http://identifiers.org/biomodels.db/MODEL1310110017#_4466b72f_79ec_419a_acb9_a367e10b559d
type: Species
name: ENTPD4
initial concentration: NaN
is: Q9Y227
initial amount: NaN
is encoded by: hsa:9583
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR DURAD2
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrothymin dehydrogenase (NADP)

http://identifiers.org/biomodels.db/MODEL1310110017#_164d2ac2_52d0_40af_ba34_a268789923f9
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: P27708
name: CAD
boundary condition: true
is encoded by: hsa:790
is: SBO:0000252
type: Species

metaR r2133
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_b4e35fa4_198a_4dba_b690_4a570676c205
is: P40394
name: ADH7
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:131
initial amount: NaN
is: SBO:0000252

metaR r2358
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_ebe8ee92_e7e8_4c43_a098_6a39f93ad981
boundary condition: true
initial concentration: NaN
type: Species
name: HAS1
is encoded by: hsa:3036
has only substance units: false
constant: false
is: SBO:0000252
is: Q8IYH3
initial amount: NaN

metaR r2509
is described by: ECO:0000000
name: Utilized transport
fast: false
reversible: true
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR r1986
modifier: MODEL1310110017#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110017#

metaM 2dr1p c
name: 2-Deoxy-D-ribose 1-phosphate
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351
is: C00672
is: CHEBI:58576

metaM urate e
is: SBO:0000247
is: CHEBI:17775
type: Species
is: C00366
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
has only substance units: false
name: Urate
is: HMDB00289

metaM asn L e
has only substance units: false
constant: false
is: HMDB00168
initial concentration: 1.0
name: L-asparagine
type: Species
is: CHEBI:17196
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false

metaM arg L c
is: HMDB00517
initial amount: NaN
name: L-argininium(1+)
constant: false
boundary condition: false
is: CHEBI:32682
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

http://identifiers.org/biomodels.db/MODEL1310110017#_f54c0f1e_3004_426a_94ff_94ebc82b7692
has only substance units: false
is encoded by: hsa:4846
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: NOS3
is: A0S0A7
is: SBO:0000252
type: Species

metaM na1 e
name: Sodium
type: Species
is: HMDB00588
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: C01330
notes: FORMULA: Na CHARGE: 1
boundary condition: false
is: CHEBI:4541
initial concentration: 1.0

metaR r2357
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110017#

metaR ITCOAL1m
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110017#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is described by: ECO:0000304
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_5d67fefe_4ca4_4b5b_aabe_7b8ceae7e7ff
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9365
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: KL
is: Q9UEF7

metaR r2022
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_bbccbfdf_69ba_428d_b31c_a9f26d5a6525
initial amount: NaN
is encoded by: hsa:7108
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O76062
name: TM7SF2
type: Species
initial concentration: NaN

metaM dgdp c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: dGDP
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
is: HMDB00960
initial concentration: 1.0
is: CHEBI:58595
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110017#_4ccafa7f_6b70_4cc3_bb32_c83d9b45cd58
initial concentration: NaN
initial amount: NaN
is: P12268
boundary condition: true
has only substance units: false
name: IMPDH2
is encoded by: hsa:3615
is: SBO:0000252
constant: false
type: Species

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_325609fd_f2f4_4a67_a06b_20578df9104a
boundary condition: true
is encoded by: hsa:115584
is: SBO:0000252
has only substance units: false
name: SLC5A11
constant: false
type: Species
initial concentration: NaN
is: Q8WWX8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_65765e8a_f125_440f_8118_22b282367254
initial amount: NaN
is encoded by: hsa:LOC728997
is: SBO:0000252
constant: false
name: _LOC728997_1_c
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM citr L e
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
type: Species
is: SBO:0000247
initial concentration: 1.0
name: citr_L[e]
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16349

metaR r1623
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_d3d432a5_a597_4ee1_ba76_f652b15edf2b
initial amount: NaN
is encoded by: hsa:9468
type: Species
boundary condition: true
name: PCYT1B
has only substance units: false
is: E9PD84
is: SBO:0000252
initial concentration: NaN
constant: false

metaM glyc m
is: HMDB00131
is: CHEBI:17754
initial concentration: 1.0
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
is: C00116
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c100492c_8e39_46e6_bfeb_af04eec7c48d
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: CA9
initial amount: NaN
is encoded by: hsa:768
is: Q16790

http://identifiers.org/biomodels.db/MODEL1310110017#_9d0c3a1c_6bfa_4785_8df0_1f832d907281
is: O95139
initial amount: NaN
name: NDUFB6
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4712
constant: false
type: Species
initial concentration: NaN

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR CITtam
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110017#
name: citrate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
modifier: MODEL1310110017#
reactant: MODEL1310110017#

metaM ksii core2 deg5 l
name: keratan sulfate II (core 2-linked), degradation product 5
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
has only substance units: false
is: CHEBI:12936
constant: false
initial concentration: 1.0
is: HMDB00143

metaR r0245
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110017#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
type: Reaction
modifier: MODEL1310110017#

metaM HC01401 m
is: CHEBI:27668
initial amount: NaN
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaM pail hs c
is: CHEBI:57880
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false

metaR r1622
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
fast: false
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction

metaM h2o g
constant: false
initial concentration: 1.0
name: water
is: CHEBI:15377
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_5e7f4034_22c9_4a87_a403_e590cda08527
constant: false
initial amount: NaN
is: Q53YB7
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: COX5B
is encoded by: hsa:1329
has only substance units: false

metaM Rtotal3 c
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01448
initial amount: NaN
boundary condition: false
is: CHEBI:16189
notes: FORMULA: CO2FULLR3 CHARGE: -1
name: R total 3 position
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_89e8bf5e_3a7a_4ce6_8fdc_02fa002e356d
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9UHW9
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC12A6
is encoded by: hsa:9990

metaM acald e
is: HMDB00990
type: Species
has only substance units: false
constant: false
name: acetaldehyde
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false
is: SBO:0000247
is: CHEBI:15343
initial concentration: 1.0

metaR r1621
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000

metaR r0246
fast: false
reversible: false
modifier: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176

metaM citr L c
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
constant: false
is: CHEBI:16349
name: L-citrulline
type: Species
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110017#_56737f67_e87d_4e7c_a7d6_c9d93dfa3821
type: Species
name: ECHS1
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1892
is: P30084
constant: false

metaM lnlncg l
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
has only substance units: false
is: HMDB03073
is: CHEBI:32391
boundary condition: false
name: gamma-linolenate
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r0268
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reactant: MODEL1310110017#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.1.3.1
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
product: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#

metaR r1910
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_c2480d18_ddee_4740_997c_f488c353f6d4
type: Species
is: SBO:0000252
name: MPI
initial concentration: NaN
is encoded by: hsa:4351
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P34949

http://identifiers.org/biomodels.db/MODEL1310110017#_293e3a1f_04c7_4666_9864_c00ebbc37cd5
is encoded by: hsa:221
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: ALDH3B1
boundary condition: true
is: SBO:0000252
is: P43353

metaM leuktrE4 c
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02200
initial amount: NaN
name: leukotriene E4(1-)
is: CHEBI:57462
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_262463f7_7cd9_480d_bf24_7cb6d30b4743
initial amount: NaN
boundary condition: true
constant: false
is: A8K0S7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2542
name: SLC37A4
type: Species
has only substance units: false

metaR DCMPDA
product: MODEL1310110017#
type: Reaction
fast: false
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.12
reversible: true
name: dCMP deaminase
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is described by: ECO:0000254
reactant: MODEL1310110017#

metaM nicrnt c
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
name: Nicotinate D-ribonucleotide
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01132
initial concentration: 1.0
is: CHEBI:57502

metaR r2130
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000

metaR KSII CORE2tly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
type: Reaction
is described by: ECO:0000000
name: keratan sulfate II (core 2) transport, extracellular to lysosome
reversible: false

metaR THFtm
product: MODEL1310110017#
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction

metaR CGLYt3 2
is described by: ECO:0000304
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110017#
reversible: false
product: MODEL1310110017#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM na1 r
is: SBO:0000247
type: Species
is: HMDB00588
constant: false
initial amount: NaN
name: sodium(1+)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: CHEBI:29101

metaR r1620
reversible: true
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
type: Reaction

metaM h2o e
initial concentration: 1.0
is: HMDB02111
name: H2O
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
has only substance units: false
is: C00001
is: CHEBI:15377
boundary condition: false
initial amount: NaN

metaR URIK1
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
name: uridine kinase (ATP:Uridine)
product: MODEL1310110017#
type: Reaction
reversible: false

metaR r2026
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reactant: MODEL1310110017#
modifier: MODEL1310110017#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM Rtotal3 e
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
name: R total 3 position
is: C00255
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:3554
is: HMDB00244

metaM acald c
constant: false
type: Species
is: SBO:0000247
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
name: acetaldehyde
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15343

metaM dhcholoylcoa x
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
has only substance units: false
is: CHEBI:27393
is: SBO:0000247
is: HMDB06895
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reversible: true
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
name: Active transport
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185

metaM 2mpdhl m
constant: false
is: CHEBI:17577
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
name: S-(2-Methylpropanoyl)-dihydrolipoamide
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_bce10111_9dd7_462d_87a6_21d95e8dd482
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:51292
name: GMPR2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM HC00229 e
type: Species
boundary condition: false
name: Isomaltose
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252

metaM h2o m
name: H2O
is: HMDB02111
initial concentration: 1.0
type: Species
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00001

metaR RE2649C
type: Reaction
is described by: ECO:0000000
name: RE2649
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
product: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#

metaM 3snpyr c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: 3-Sulfinopyruvate
is: CHEBI:1665
is: HMDB02332
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_024dc612_8146_457d_a7b3_7dc68aa9717d
is encoded by: hsa:51268
name: PIPOX
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9P0Z9
type: Species

metaR CHSTEROLtrc
is: SBO:0000185
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
name: transport of cholesterol into the cytosol
type: Reaction
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
fast: false
is described by: ECO:0000134

metaM ppi c
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
is: HMDB00250
has only substance units: false
type: Species
name: Diphosphate
is: C00013
is: CHEBI:0
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM lnlncg r
is: CHEBI:32391
is: HMDB03073
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r2027
type: Reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR DGK1
kinetic law: MODEL1310110017#
fast: false
is: SBO:0000176
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: deoxyguanylate kinase (dGMP:ATP)

metaR HMGLm
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
type: Reaction
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reversible: false
name: hydroxymethylglutaryl-CoA lyase
reactant: MODEL1310110017#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR MECOALm
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176
type: Reaction
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110017#
is described by: ECO:0000212

metaM h2o l
initial concentration: 1.0
is: CHEBI:15377
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: water
is: SBO:0000247
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110017#_e1cf5dd6_e4f4_45a3_8308_69c6d3e39bd9
is: P23786
name: CPT2
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1376

metaR r0267
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:

metaM pmtcoa c
constant: false
is: HMDB01338
boundary condition: false
initial amount: NaN
type: Species
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
is: CHEBI:3454
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaM leuktrE4 e
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB02200
is: CHEBI:57462
name: leukotriene E4(1-)
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM akg x
is: HMDB00208
initial concentration: 1.0
initial amount: NaN
name: 2-oxoglutarate(2-)
type: Species
has only substance units: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
is: CHEBI:16810
is: SBO:0000247

metaR RE2079R
is described by: ECO:0000000
name: RE2079
product: MODEL1310110017#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c6bf67f9_4e97_473d_92e5_f72aadd0fda4
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: PEMT
is: Q9UBM1
is encoded by: hsa:10400
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_69525ae5_7bec_4da3_bcd7_d8b585482190
name: _AI440329_1_r
boundary condition: true
is encoded by: hsa:AI440329
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_dfef8c1c_896f_4ebd_a5a2_ba41750d452f
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:125965
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: COX6B2
is: Q6YFQ2

http://identifiers.org/biomodels.db/MODEL1310110017#_30dc2add_e62e_4827_becf_e61d0ba12dc7
name: PRDX1
is encoded by: hsa:5052
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q06830
initial concentration: NaN
constant: false
initial amount: NaN

metaR UMPK5n
product: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110017#

metaR r0946
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaR SO4CLtex2
kinetic law: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
name: sulfate transport via chloride countertransport (2:1)
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
is described by: ECO:0000304

metaR r0242
product: MODEL1310110017#
is: SBO:0000176
reactant: MODEL1310110017#
is described by: ECO:0000000
reversible: true
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
kinetic law: MODEL1310110017#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM CE2424 m
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
constant: false
is: HMDB11123
type: Species
is: CHEBI:28387
initial concentration: 1.0

metaM 1p3h5c m
has only substance units: false
boundary condition: false
constant: false
is: HMDB01369
is: CHEBI:6151
initial amount: NaN
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species

metaM 56dura c
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: CHEBI:15901
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB00076

metaM icit c
is: C00311
is: CHEBI:16087
has only substance units: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
name: Isocitrate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00193
initial amount: NaN
type: Species

metaR r1833
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR MAN1PT2
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.7.13
name: mannose-1-phosphate guanylyltransferase (GDP)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
product: MODEL1310110017#
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110017#

metaR r0193
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
fast: false
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
kinetic law: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_4f999306_e0e4_45a7_93da_fedc615a5abe
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110017#_35282da3_8ffa_4ce0_980c_1995d36f0673
is: O00767
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: SCD
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6319

metaR ALAGLNexR
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
name: L-alanine/glutamine reversible exchange
reversible: true
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#

metaM core6 l
is: HMDB00143
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Core 6
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: CHEBI:12936

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR CSNt
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
is described by: ECO:0000269
name: cytosine transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#

metaR PAFHe
is version of: http://identifiers.org/ec-code/3.1.1.47
name: Platelet-activating factor acetylhydrolase
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110017#_fe27a1df_512f_4f51_8f87_b123825ba255
constant: false
name: GGT7
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2686
is: A0PJJ9

metaM man e
name: D-Mannose
is: HMDB00169
has only substance units: false
boundary condition: false
is: CHEBI:16024
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: C00159

metaR r1546
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_5a2104bd_cfa9_4c20_ba22_a9fba258aefd
initial amount: NaN
constant: false
is encoded by: hsa:9963
name: SLC23A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR SUCCt2m
reversible: true
name: succinate transport, mitochondrial
product: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110017#
type: Reaction
fast: false

metaM HC02205 c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
name: prostaglandin-b2
initial amount: NaN
is: CHEBI:28099
is: SBO:0000247
has only substance units: false

metaR LEUKTRB4t
type: Reaction
name: leukotriene B4 transport
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110017#
fast: false
reversible: true
reactant: MODEL1310110017#

metaM trdox c
boundary condition: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
name: Oxidized thioredoxin
is: CHEBI:18191
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: C00343

metaR r1616
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#

metaR RE2659R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
name: RE2659
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false

metaM cl c
initial amount: NaN
boundary condition: false
is: C00115
name: Chloride
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
type: Species
is: CHEBI:3966
is: SBO:0000247
constant: false
is: HMDB00492

metaM orn c
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: HMDB00214
is: C01602
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:0
has only substance units: false
name: Ornithine
is: SBO:0000247

MODEL1310110017#
species: metaM udp c
species: metaM coa l
stoichiometry: 0.545544
species: metaM dhlam m
species: metaM glyc R c
species: metaM ak2lgchol hs e
kind: SECOND
species: metaM fmn c
species: metaM g6p c
species: metaM gam6p c
species: metaM pmtcoa c
species: metaM val L c
species: metaM dcholcoa r
species: metaM tsul m
species: metaM h n
species: metaM udpg r
species: metaM xan c
species: metaM cholcoa c
species: metaM ksii core2 l
species: metaM itp c
species: metaM HC02202 e
species: metaM retinal cis 13 r
species: metaM CE0693 m
species: metaM dtmp m
species: metaM xol7aone r
species: metaM HC01403 m
species: metaM retinal c
species: metaM dgsn e
species: metaM cit e
species: metaM btn c
species: metaM chsterol r
species: metaM glyc e
species: metaM coa n
species: metaM 1pyr5c m
species: metaM dgdp n
species: metaM pac c
species: metaM no c
species: metaM prpp e
species: metaM glu5sa c
species: metaM dc2coa m
species: metaM 6dhf m
species: metaM glyc R m
species: metaM xu5p D c
species: metaM val L e
species: metaM tchola e
species: metaM pail45p hs n
species: metaM sucsal m
species: metaM fadh2 c
stoichiometry: 0.013091
species: metaM HC02213 c
stoichiometry: 0.009898
species: metaM 5dhf l
species: metaM lac L x
species: metaM adrnl c
species: metaM gchola c
species: metaM accoa c
species: metaM ump e
species: metaM itp n
species: metaM malttr e
species: metaM cmpacna c
species: metaM succoa m
species: metaM ptth m
species: metaM anth c
species: metaM uacgam c
species: metaM pe hs m
species: metaM 3sala c
species: metaM cys L e
species: metaM retn r
species: metaM pmtcoa r
species: metaM h2o2 x
species: metaM asn L e
species: metaM dtdp m
species: metaM ac c
stoichiometry: 0.017486
species: metaM no e
species: metaM gln L m
species: metaM ha pre1 l
species: metaM HC01434 x
species: metaM xol7ah c
species: metaM 3hibutcoa m

http://identifiers.org/biomodels.db/MODEL1310110017#_e6e4293a_e33e_43ea_a024_ad2ffb6bd00f
name: ADH1A
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P07327
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:124

metaM orn e
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:0
type: Species
initial concentration: 1.0
is: HMDB00214
is: C01602
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
name: Ornithine

metaR r0841
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.271
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false
name: Free diffusion
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_ddae03e0_252c_4ecf_9613_543d894bb8ad
initial amount: NaN
is: O00219
name: HAS3
has only substance units: false
type: Species
is encoded by: hsa:3038
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_c7b2f9b2_5235_4e8f_b810_7987d8c0b754
is encoded by: hsa:389015
is: SBO:0000252
name: SLC9A4
constant: false
boundary condition: true
initial concentration: NaN
is: Q6AI14
type: Species
has only substance units: false
initial amount: NaN

metaM mal L m
initial concentration: 1.0
is: HMDB00156
constant: false
name: (S)-malate(2-)
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589

metaM HC01410 m
initial amount: NaN
is: CHEBI:28706
has only substance units: false
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: (2E)-Hexenoyl-CoA

metaR PItx
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_d96a2140_fee5_422b_8483_25aee6a32b53
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26330
name: GAPDHS
is: O14556
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM ha pre1 l
name: hyaluronan biosynthesis, precursor 1
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: CHEBI:16126
initial amount: NaN
type: Species

metaR r1617
type: Reaction
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_21725491_9c6b_46df_8fdf_105355a21c2e
type: Species
initial concentration: NaN
name: DGKD
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8527
is: SBO:0000252
initial amount: NaN

metaR DNDPt29m
fast: false
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
name: dCDP transport via dADP antiport

http://identifiers.org/biomodels.db/MODEL1310110017#_72162d54_3242_4e90_8159_1884f876b0c8
is: SBO:0000252
boundary condition: true
name: SLC26A4
has only substance units: false
is: O43511
initial amount: NaN
is encoded by: hsa:5172
initial concentration: NaN
constant: false
type: Species

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM 3hmp m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
is: CHEBI:11805
has only substance units: false
is: HMDB00023
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188

metaR AMETr
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: S-Adenosyl-L-methionine intracellular diffusion
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reversible: true
kinetic law: MODEL1310110017#

metaR r0464
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3

metaM HC02205 e
is: SBO:0000247
is: CHEBI:28099
has only substance units: false
constant: false
initial concentration: 1.0
name: prostaglandin-b2
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaM HC01434 x
type: Species
initial amount: NaN
is: CHEBI:58931
constant: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
name: oxalatosuccinate(3-)
is: SBO:0000247
boundary condition: false

metaR r1544
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR 4MOPt2im
type: Reaction
is described by: ECO:0000000
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
reversible: false
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaM man c
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
is: SBO:0000247
is: C00159
initial concentration: 1.0
is: HMDB00169
has only substance units: false
type: Species
constant: false
is: CHEBI:16024
boundary condition: false

metaM CE2839 e
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial amount: NaN
is: SBO:0000247
name: maltodecaose
is: C01936
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_34305d74_63b0_4128_9523_47c48f75d512
name: ACP6
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51205
initial amount: NaN
is: Q9NPH0

http://identifiers.org/biomodels.db/MODEL1310110017#_b125d1bd_9cd6_4b2e_a173_0f2e7428444f
constant: false
initial concentration: NaN
is: P28329
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1103
name: CHAT

metaR r1618
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110017#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110017#

metaR CYTDt
is described by: ECO:0000269
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
name: cytidine facilated transport in cytosol
fast: false
type: Reaction
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110017#
is: SBO:0000185

metaM cl e
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
initial concentration: 1.0
has only substance units: false
is: C00115
is: CHEBI:3966
boundary condition: false
name: Chloride
initial amount: NaN

metaR BILIRUBt2
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
type: Reaction
reversible: true
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaM ppi x
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
is: HMDB00250
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:33019
type: Species
is: SBO:0000247
initial amount: NaN

metaR RE1709C
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
name: RE1709
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_998aeb57_f2fb_4238_abd7_73531c5d71e0
is: B3KN25
has only substance units: false
constant: false
initial amount: NaN
name: CEPT1
is encoded by: hsa:10390
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0688
product: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110017#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110017#_703d1087_a2ab_4b76_95bb_c45dde36ffea
is: SBO:0000252
name: UROD
type: Species
initial amount: NaN
is encoded by: hsa:7389
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: P06132

metaR FPGS5m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.17
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
name: folylpolyglutamate synthetase (DHF), mitochondrial

metaR r1619
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_21157e5c_26d5_4ec6_a220_5bde87e1d7cc
is encoded by: hsa:53
is: E9PCI1
name: ACP2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaM cholate c
initial amount: NaN
name: Cholate
constant: false
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
type: Species
has only substance units: false
is: CHEBI:29747
boundary condition: false
initial concentration: 1.0

metaR 3MOPte
is: SBO:0000185
reversible: true
is described by: ECO:0000134
product: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
name: Transport of 3-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110017#_a3839e5e_c344_4d3b_813f_43bff712aed5
initial amount: NaN
is encoded by: hsa:8898
is: SBO:0000252
constant: false
name: MTMR2
boundary condition: true
type: Species
is: A6NN98
initial concentration: NaN
has only substance units: false

metaR r1612
reversible: true
is: SBO:0000185
product: MODEL1310110017#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#

metaM fald c
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01426
has only substance units: false
constant: false
initial amount: NaN
name: formaldehyde

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
initial concentration: 1.0
is: CHEBI:27931
boundary condition: false
constant: false
name: maltotriose
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C01835

metaM glc D r
is: SBO:0000247
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:4167
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00122

http://identifiers.org/biomodels.db/MODEL1310110017#_cea3c954_96f7_4175_8632_af9294b1236a
boundary condition: true
initial amount: NaN
type: Species
is: Q8NEM3
name: SLC16A7
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:9194

metaR ETOHt
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110017#
product: MODEL1310110017#
name: ethanol reversible transport
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaR r1613
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#
reversible: true
type: Reaction
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_23a2b14f_3721_4226_bbb4_5b0aee8a524e
has only substance units: false
is: P48448
boundary condition: true
is: SBO:0000252
is encoded by: hsa:222
name: ALDH3B2
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR r0686
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110017#
product: MODEL1310110017#

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58178

http://identifiers.org/biomodels.db/MODEL1310110017#_f4bbaa3d_bb8b_4632_b881_715091fd712f
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9058
initial amount: NaN
name: SLC13A2
has only substance units: false
is: SBO:0000252
boundary condition: true
is: E7ETH5

metaR r0845
product: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
reactant: MODEL1310110017#
reversible: false
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
kinetic law: MODEL1310110017#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_6a7394de_281a_4e08_af07_92be71d7c5aa
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1633
initial concentration: NaN
type: Species
is: P27707
name: DCK
has only substance units: false

metaR O2ter
is: SBO:0000185
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
name: O2 transport, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_433fb656_de28_4fc9_ba0c_6b891cebb001
initial amount: NaN
is encoded by: hsa:2936
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: P00390
name: GSR
initial concentration: NaN
boundary condition: true

metaR r1549
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110017#
reversible: true

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110017#

metaR r1548
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_c89e5fbd_ad6e_4a61_9baf_2294b3273f42
is encoded by: hsa:1606
is: P23743
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: DGKA
has only substance units: false
type: Species
initial concentration: NaN

metaM g6p r
initial concentration: 1.0
type: Species
constant: false
name: D-Glucose 6-phosphate
is: C00092
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:61548
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401

metaR INSTt4
fast: false
is: SBO:0000185
modifier: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
name: inositol transport via sodium symport
type: Reaction
reversible: true
kinetic law: MODEL1310110017#

metaR r1291
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110017#
name: Postulated transport reaction
reactant: MODEL1310110017#
product: MODEL1310110017#

metaR r0842
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
name: Postulated transport reaction
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_09107462_2673_4ef5_9b23_ce464aa3b865
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P31040
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: SDHA
is encoded by: hsa:6389

metaM mal L e
boundary condition: false
is: HMDB00156
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:15589
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
constant: false
name: (S)-malate(2-)
initial concentration: 1.0

metaR GLNS
is version of: http://identifiers.org/ec-code/4.1.1.15
name: glutamine synthetase
product: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110017#
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_fc9f3504_c8a6_4b55_bd7b_d4904d4c8def
initial amount: NaN
boundary condition: true
name: _J03866_1_m
type: Species
is encoded by: hsa:J03866
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

metaR RE0958E
reactant: MODEL1310110017#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:

metaM thbpt c
is: HMDB00027
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
name: 5,6,7,8-tetrahydrobiopterin
is: SBO:0000247
is: CHEBI:15372
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0

metaR r1547
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110017#_81aaf62f_4b8f_4f75_be42_c39d666c5c95
is: P47895
type: Species
is: SBO:0000252
name: ALDH1A3
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:220
initial amount: NaN
initial concentration: NaN

metaM ficytC m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: CHEBI:15991
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Ferricytochrome c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_8a38bb3c_17cb_4afd_bf4e_fb01520ecbac
constant: false
type: Species
name: HSD3B2
is: P26439
boundary condition: true
is encoded by: hsa:3284
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r1615
reactant: MODEL1310110017#
type: Reaction
kinetic law: MODEL1310110017#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110017#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gln L m
constant: false
is: CHEBI:18050
is: HMDB00641
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
boundary condition: false

metaR RE3381E
reactant: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
name: RE3381
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
fast: false

metaR CYTK1n
is described by: ECO:0000269
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
fast: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR r2353
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM prostgd2 r
boundary condition: false
is: HMDB01403
is: SBO:0000247
name: prostaglandin D2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial amount: NaN
has only substance units: false
is: CHEBI:57406
type: Species
constant: false

metaM acmana e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17122
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
name: N-acetyl-D-mannosamine
constant: false
has only substance units: false
is: SBO:0000247

metaM akg e
type: Species
has only substance units: false
boundary condition: false
is: HMDB00208
name: 2-oxoglutarate(2-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
initial concentration: 1.0
constant: false

metaM datp n
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
is: CHEBI:61404
constant: false
initial amount: NaN
is: SBO:0000247
name: dATP
boundary condition: false
is: HMDB01532
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_f7c352ad_6a62_4d29_8bb2_06e67d3135a6
is: SBO:0000252
is encoded by: hsa:51727
initial amount: NaN
initial concentration: NaN
constant: false
name: CMPK1
is: B2R6S5
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_eb836133_05ae_4124_985b_fe359e498fae
has only substance units: false
is encoded by: hsa:9374
initial concentration: NaN
is: Q9UMR5
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: PPT2

metaM mal L c
has only substance units: false
name: (S)-malate(2-)
boundary condition: false
type: Species
constant: false
is: CHEBI:15589
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
initial amount: NaN

metaR r0735
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
reactant: MODEL1310110017#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_278d8d61_05e6_451b_88db_0c7f90c2d823
initial amount: NaN
is encoded by: hsa:412
type: Species
is: P08842
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: STS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_3fb3d4e1_09b2_4848_b728_9ec8deb76621
is: SBO:0000252
name: NDUFA12
is encoded by: hsa:55967
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: F8VQS7

metaR UMPK3
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP)
modifier: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
reactant: MODEL1310110017#

metaM chsterol r
initial amount: NaN
boundary condition: false
is: CHEBI:16113
name: cholesterol
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false

metaM fadh2 m
name: Flavin adenine dinucleotide reduced
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01197
is: CHEBI:58307
has only substance units: false
boundary condition: false
constant: false
is: C01352
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_b478753f_fa85_4c03_b924_63588a67691d
initial concentration: NaN
is encoded by: hsa:126328
constant: false
has only substance units: false
name: NDUFA11
type: Species
initial amount: NaN
is: C9JT23
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_aaf6927a_e1e9_442f_aed8_5afc8e2c96fc
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: Q16795
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4704
name: NDUFA9

metaR H2Oter
is: SBO:0000185
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
product: MODEL1310110017#
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaR CYTK1m
reactant: MODEL1310110017#
reversible: true
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110017#
name: cytidylate kinase (CMP),mitochondrial
product: MODEL1310110017#
type: Reaction
fast: false

metaR RE1709N
reversible: true
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: RE1709
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110017#
type: Reaction

metaR r2354
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_b6a85c38_fb35_483e_b545_139d9d9ba0d5
has only substance units: false
is: Q9NSC7
constant: false
name: ST6GALNAC1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55808
boundary condition: true
type: Species

metaM ahcys r
initial amount: NaN
name: S-adenosyl-L-homocysteine
is: HMDB00939
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16680

metaM ppi n
is: HMDB00250
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: diphosphate(3-)
is: SBO:0000247
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false

metaR UMPK4
reactant: MODEL1310110017#
type: Reaction
name: UMP kinase (GTP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_33ce924c_b77a_4c4f_9eae_c54f6e0a6f34
is: P34059
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2588
name: GALNS
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:35418
initial concentration: 1.0
name: N-acetylneuraminate
is: SBO:0000247
type: Species
is: HMDB00230
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_718b40ab_dbda_4093_b19f_6da8c4dee777
is encoded by: hsa:AA629629
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: _AA629629_1_m
has only substance units: false
is: SBO:0000252
constant: false

metaR DHCRD2
product: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
name: dihydroceramide desaturase

metaM akg c
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
constant: false
type: Species
boundary condition: false
name: 2-Oxoglutarate
is: HMDB00208
is: CHEBI:16810
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR GLUDxm
is: SBO:0000176
modifier: MODEL1310110017#
reactant: MODEL1310110017#
type: Reaction
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NAD) (mitochondrial)
fast: false
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110017#_cce95fc3_51c0_4039_9499_457d7e52ac82
boundary condition: true
is encoded by: hsa:56954
initial concentration: NaN
type: Species
name: NIT2
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q9NQR4

metaM glutcoa m
initial concentration: 1.0
constant: false
type: Species
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57378
name: glutaryl-CoA(5-)

metaR CYTDK2m
fast: false
product: MODEL1310110017#
is described by: ECO:0000000
reactant: MODEL1310110017#
name: cytidine kinase (ATP), mitochondrial
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000176

metaR r2355
reactant: MODEL1310110017#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#

metaM CE2433 m
is: C01936
boundary condition: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: SBO:0000247
initial amount: NaN
constant: false

metaR UMPK5
kinetic law: MODEL1310110017#
reversible: true
name: UMP kinase (dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_00b87b32_1f46_42bc_b5dc_8091633d8805
is encoded by: hsa:224
initial concentration: NaN
is: SBO:0000252
is: P51648
initial amount: NaN
name: ALDH3A2
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
name: cytidylate kinase (dCMP),nuclear
type: Reaction
reversible: true
kinetic law: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_b15ebe03_1f94_48f1_9132_8d2e032e62f1
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4513
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q7GXZ8
has only substance units: false
name: COX2

metaM 3aib D c
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: D-3-Amino-isobutanoate
type: Species
is: HMDB02299

metaR r2356
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110017#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000

metaM datp m
type: Species
is: HMDB01532
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61404
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
boundary condition: false
initial concentration: 1.0

metaR PSSA1 hs
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
reversible: true
name: Phosphatidylserine synthase homo sapiens

metaR r2516
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110017#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_30627f6b_6718_4d58_8ac9_6af36e555bf6
type: Species
is: P51648
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:224
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDH3A2

http://identifiers.org/biomodels.db/MODEL1310110017#_136097c7_ba0e_447f_889b_2ea21cbf1899
is: SBO:0000252
constant: false
is encoded by: hsa:2639
is: Q92947
initial amount: NaN
name: GCDH
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_bb9ff533_dcad_435f_979b_f9bc81740714
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:T83654
initial concentration: NaN
name: _T83654_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_3ade9c8a_d912_4e7e_a4fb_a14348f5cd3e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P51553
type: Species
initial amount: NaN
name: IDH3G
boundary condition: true
is encoded by: hsa:3421
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_b8049f2c_f8a5_47ba_82aa_d3b27c9c3cae
has only substance units: false
initial concentration: NaN
constant: false
name: SLC17A3
initial amount: NaN
is encoded by: hsa:10786
boundary condition: true
is: SBO:0000252
is: O00476
type: Species

metaR UMPK6
is: SBO:0000176
fast: false
product: MODEL1310110017#
reversible: true
name: UMP kinase (dCTP)
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110017#
type: Reaction

metaM crn x
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
name: L-Carnitine
is: CHEBI:16347
type: Species
is: C00318
is: HMDB00062
is: SBO:0000247
initial amount: NaN
constant: false

metaR r0680
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR ALAGLYexR
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000304
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: L-alanine/glycine reversible exchange
fast: false
kinetic law: MODEL1310110017#
is: SBO:0000185
type: Reaction

metaM ahcys m
type: Species
name: S-Adenosyl-L-homocysteine
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
is: C00021
boundary condition: false
initial amount: NaN
is: CHEBI:16680
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_18512612_2ec3_4ab5_ba10_2dd3cdadc164
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:219
is: P30837
name: ALDH1B1
is: SBO:0000252

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM dcyt c
initial concentration: 1.0
type: Species
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false
is: CHEBI:15698
boundary condition: false
is: C00881
is: SBO:0000247
constant: false
initial amount: NaN
name: Deoxycytidine

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM 3aib D e
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
name: D-3-Amino-isobutanoate
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02299
is: C03265
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR HSD3B7P
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
is version of: http://identifiers.org/ec-code/1.1.1.181
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#

metaM xol7ah2al c
is: CHEBI:27428
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06894
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_6a92039e_c82b_42fa_b8cb_09496ded14d0
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9154
initial amount: NaN
boundary condition: true
is: Q96PL7
constant: false
name: SLC28A1
type: Species
has only substance units: false

metaM ppi r
is: SBO:0000247
is: HMDB00250
type: Species
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: CHEBI:33019
initial concentration: 1.0
initial amount: NaN
name: Diphosphate
is: C00013
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_247e011b_0c6f_43cf_8f00_eb4d992911f2
initial concentration: NaN
is encoded by: hsa:5831
constant: false
is: P32322
has only substance units: false
initial amount: NaN
name: PYCR1
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_fc571c9d_7cde_4ff0_afc0_15b9bc8e448c
type: Species
is: Q15181
is encoded by: hsa:5464
is: SBO:0000252
name: PPA1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM atp x
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00538
name: ATP(4-)
is: C00002
is: SBO:0000247
boundary condition: false
is: CHEBI:57299
has only substance units: false
constant: false

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM C05965 e
constant: false
has only substance units: false
type: Species
name: 12(S)-HPETE(1-)
initial amount: NaN
initial concentration: 1.0
is: HMDB04243
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
boundary condition: false
is: CHEBI:57444
is: SBO:0000247

metaM gln L c
has only substance units: false
is: CHEBI:18050
constant: false
type: Species
is: HMDB00641
initial concentration: 1.0
initial amount: NaN
name: L-glutamine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaM lcts e
initial concentration: 1.0
is: HMDB00186
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
type: Species
initial amount: NaN
name: Lactose
is: C00243
is: CHEBI:17716

metaR r2511
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110017#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110017#
reversible: true
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110017#_e4995a77_58b4_4d7d_a133_8cab67382631
is encoded by: hsa:AL525798
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AL525798_1_c
is: SBO:0000252

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: sphinganine(1+)
is: SBO:0000247
type: Species
is: HMDB00269
has only substance units: false
is: CHEBI:57817

http://identifiers.org/biomodels.db/MODEL1310110017#_1ea0d7c0_603d_4cf9_b039_3c26552daf0a
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: P30838
type: Species
name: ALDH3A1
is encoded by: hsa:218
initial amount: NaN
has only substance units: false

metaR 2HBO
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110017#
reversible: true
kinetic law: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110017#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_9e48cde5_0ccb_4547_a423_076d70485927
is: Q92911
has only substance units: false
is encoded by: hsa:6528
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: SLC5A5
is: SBO:0000252

metaM chsterol l
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
initial amount: NaN
name: cholesterol
initial concentration: 1.0
is: HMDB00067
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_c4ae6fa3_b2ae_42a5_9f06_76e0366a1919
initial amount: NaN
name: _AI620219_1_m
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI620219

metaM dcyt e
name: Deoxycytidine
initial concentration: 1.0
is: HMDB00014
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
is: C00881
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaR r1299
fast: false
reactant: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110017#
name: Vesicular transport
product: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c2501af2_93ba_46c2_9a14_9e86222054ff
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:771
is: O43570
has only substance units: false
name: CA12
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_d0198929_f49c_4a14_b999_1444bb08430f
name: _AI972237_1_c
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI972237
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_c6f6c0c3_b47e_4845_9246_7624e1e20e3c
name: EARS2
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:124454
is: Q5JPH6
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_c95b2b1f_378a_417a_9455_6e339f814cf1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI684467
has only substance units: false
name: _AI684467_1_m
constant: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_03b5f04f_91c0_486c_b85e_2bbb93ab41df
is encoded by: hsa:H77542
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _H77542_1_c
constant: false
is: SBO:0000252

metaM ha pre1 e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16126
initial concentration: 1.0
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
name: hyaluronan biosynthesis, precursor 1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_03eaea5e_91a6_4856_aafe_793023f45449
is encoded by: hsa:4702
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: B1AM93
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFA8

metaR r1540
reactant: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110017#
product: MODEL1310110017#
modifier: MODEL1310110017#
type: Reaction

metaM pan4p m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:47942
is: SBO:0000247
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: pantetheine 4'-phosphate(2-)
boundary condition: false
type: Species

metaM sph1p e
constant: false
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
initial concentration: 1.0

metaM sph1p c
is: HMDB01383
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
is: CHEBI:57939
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR r2512
product: MODEL1310110017#
name: Utilized transport
fast: false
type: Reaction
kinetic law: MODEL1310110017#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110017#

metaR DM datp m
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dATP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_60021c11_73be_46ca_a43f_e59f4d9043f6
has only substance units: false
boundary condition: true
name: _AF116616_1_m
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AF116616
initial concentration: NaN
initial amount: NaN

metaR DALAt2r
modifier: MODEL1310110017#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
fast: false
type: Reaction
reversible: true
product: MODEL1310110017#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#

metaR r2352
product: MODEL1310110017#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is: SBO:0000185
fast: false

metaR r2139
is described by: ECO:0000000
modifier: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
product: MODEL1310110017#
reversible: true

metaM chsterol m
is: HMDB00067
has only substance units: false
is: CHEBI:16113
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_24d3fbb0_8565_40b8_ace4_ae792c23117f
has only substance units: false
type: Species
is encoded by: hsa:AA664770
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AA664770_1_m
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_ad4e0d91_eb71_4864_818e_ef2665174d31
name: ACADL
is encoded by: hsa:33
constant: false
has only substance units: false
type: Species
is: P28330
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_e69fb140_ea9e_4417_9737_9cd99af5ee36
is: Q9NVS9
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:55163
initial concentration: NaN
constant: false
name: PNPO

metaR RE1530C
product: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000176
kinetic law: MODEL1310110017#
name: RE1530
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM gln L e
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00641
type: Species
has only substance units: false
is: CHEBI:18050
name: L-glutamine

http://identifiers.org/biomodels.db/MODEL1310110017#_26cb8eec_0355_464a_8e97_9730b43f922e
is encoded by: hsa:1716
name: DGUOK
is: E5KSL6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_31f86855_304b_4c37_a678_1ae275439a88
has only substance units: false
is encoded by: hsa:AI469183
boundary condition: true
initial amount: NaN
name: _AI469183_1_x
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR r1298
reversible: false
product: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_c5c1d679_f7ae_40c7_abbc_b01bc2812853
name: SLC26A6
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: Q9Y3Y1
is encoded by: hsa:65010
is: SBO:0000252
type: Species

metaR PAIL4P HStn
kinetic law: MODEL1310110017#
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR UMPK2
type: Reaction
is: SBO:0000176
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110017#
name: UMP kinase (CTP)

http://identifiers.org/biomodels.db/MODEL1310110017#_3096a4f2_b097_4836_8c80_6e45b8028299
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2184
has only substance units: false
name: FAH
initial amount: NaN
is: P16930
type: Species
is: SBO:0000252

metaR RPEc
reversible: true
product: MODEL1310110017#
is described by: ECO:0000134
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is: SBO:0000176
type: Reaction
name: ribulose 5-phosphate 3-epimerase
fast: false
reactant: MODEL1310110017#

metaR r1993
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110017#
is: SBO:0000185
modifier: MODEL1310110017#
fast: false
reactant: MODEL1310110017#
reversible: false
type: Reaction

metaR RE3218C
fast: false
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
name: RE3218
kinetic law: MODEL1310110017#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: CHEBI:16347
initial concentration: 1.0
type: Species
is: HMDB00062
has only substance units: false
initial amount: NaN
name: (R)-carnitine
constant: false
boundary condition: false

metaR RTOTALt
name: RTOTAL transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110017#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_eff45787_4b7f_45de_957a_40a095bc506e
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: B4DK61
name: ACOX1
is encoded by: hsa:51
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_d9949207_6b79_462d_a137_118495e302a2
type: Species
name: SLC6A5
constant: false
is: Q9Y345
is: SBO:0000252
is encoded by: hsa:9152
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR ECOAH9m
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110017#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reversible: true
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_abdf1a93_f578_417a_8f86_289133711f16
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: TXNRD1
is: SBO:0000252
is encoded by: hsa:7296

metaR LEUKTRA4t
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
type: Reaction
product: MODEL1310110017#
kinetic law: MODEL1310110017#
reversible: true
fast: false
is described by: ECO:0000269

metaR ACALDtm
type: Reaction
kinetic law: MODEL1310110017#
name: acetaldehyde mitochondrial diffusion
reactant: MODEL1310110017#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
product: MODEL1310110017#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110017#_ebc3beb2_e75c_4245_9683_f5d2009ace53
has part: P14854
is encoded by: hsa:170712
has only substance units: false
has part: Q7GXZ8
is encoded by: hsa:1349
has part: P09669
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:341947
is encoded by: hsa:4514
has part: P24311
is encoded by: hsa:84701
is encoded by: hsa:1346
is encoded by: hsa:9377
has part: P13073
has part: H0UI06
is encoded by: hsa:1339
is encoded by: hsa:1329
has part: Q7Z4L0
has part: Q7GXY8
initial concentration: NaN
has part: P20674
has part: Q6YFQ2
is encoded by: hsa:4513
is encoded by: hsa:1345
initial amount: NaN
is encoded by: hsa:1351
is encoded by: hsa:4512
is: SBO:0000297
boundary condition: true
is encoded by: hsa:125965
type: Species
has part: Q53XN1
has part: Q53YB7
is encoded by: hsa:1347
is encoded by: hsa:1337
has part: Q8TF08
is encoded by: hsa:9167
has part: Q96KJ9
has part: Q6FGA0
is encoded by: hsa:1340
constant: false
has part: P12074
is encoded by: hsa:1327
has part: P15954
has part: P24310
has part: Q02221
is encoded by: hsa:1350
has part: P00414

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR PItg
reversible: false
name: phosphate transport, Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#

metaR HSD3A1r
is: SBO:0000176
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110017#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
reactant: MODEL1310110017#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaR CLFORtex
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000185
name: chloride transport via formate countertransport
fast: false
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaM 3sala c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
constant: false
name: 3-Sulfino-L-alanine
has only substance units: false
is: CHEBI:61085
is: C00606

http://identifiers.org/biomodels.db/MODEL1310110017#_76fbc422_1653_4bd3_a43c_c2009a2103b0
has only substance units: false
name: _R51273_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:R51273
boundary condition: true
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_d4e1c644_6a8f_4094_9e1a_0d33252b62ba
initial amount: NaN
has only substance units: false
type: Species
name: GALNT5
constant: false
initial concentration: NaN
is: SBO:0000252
is: A5PKZ1
boundary condition: true
is encoded by: hsa:11227

metaM ser D c
constant: false
is: SBO:0000247
is: CHEBI:16523
type: Species
is: HMDB03406
name: D-serine
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_de5a3bc2_6385_4c6b_9abf_fcf503722d31
initial concentration: NaN
name: DGKQ
is: P52824
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1609
is: SBO:0000252
constant: false
initial amount: NaN

metaM CE1926 e
is: CHEBI:15748
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
is: SBO:0000247
type: Species
name: gama-carboxyethyl-hydroxychroman
initial amount: NaN
is: HMDB00127
constant: false
initial concentration: 1.0
boundary condition: false

metaR HISTAtu
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
reversible: true
name: Histamine uniport
fast: false
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
kinetic law: MODEL1310110017#
product: MODEL1310110017#

metaM acnam l
type: Species
is: HMDB00230
constant: false
is: SBO:0000247
is: CHEBI:35418
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate

http://identifiers.org/biomodels.db/MODEL1310110017#_1cb64c0f_38a0_40b4_8204_a7f9adc8e7f4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:H17063
name: _H17063_1_m
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1106
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
product: MODEL1310110017#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
name: Postulated transport reaction

metaM g6p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:61548
type: Species
is: HMDB01401
is: C00092
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_43631bcf_2580_42dc_82db_b815f67156a5
name: MTHFD2
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10797
type: Species
is: P13995
is: SBO:0000252
initial concentration: NaN

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR ICDHy
product: MODEL1310110017#
modifier: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
reversible: false
name: isocitrate dehydrogenase (NADP)

metaR PCHOL HSter
name: phosphatidylcholine scramblase
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_3f132e79_9283_498b_9ed6_96caa65138c9
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AD000092
name: _AD000092_1_c
constant: false

metaR UDPtl
fast: false
reversible: true
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
name: udp intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM 20ahchsterol m
boundary condition: false
name: 20-hydroxycholesterol
is: SBO:0000247
is: CHEBI:1296
has only substance units: false
constant: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
initial concentration: 1.0
is: HMDB06283
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_f4f2f32a_21a0_40b9_a5a3_d461bc0c3623
is: P23921
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6240
name: RRM1

metaM retn r
type: Species
has only substance units: false
is: CHEBI:35291
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
constant: false
name: all-trans-retinoate
initial concentration: 1.0
is: HMDB01852
initial amount: NaN

metaR RE2660N
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
modifier: MODEL1310110017#
name: RE2660
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_b3a46c73_6ae4_452c_83a4_a909ddfc7ab1
name: ALDH9A1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:223
type: Species
is: SBO:0000252
initial amount: NaN
is: P49189
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_77f39791_f555_40c9_89c0_4dad07d50efe
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51005
initial amount: NaN
type: Species
is: Q9Y303
initial concentration: NaN
constant: false
name: AMDHD2

http://identifiers.org/biomodels.db/MODEL1310110017#_971d288c_74b8_4ca4_a4fa_e964ca58c426
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: B1AK53
name: ESPN
initial concentration: NaN
is encoded by: hsa:83715
boundary condition: true

metaM udp r
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: C00015
name: UDP
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR 2AMADPTm
kinetic law: MODEL1310110017#
reversible: true
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
is described by: ECO:0000269
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
type: Reaction
fast: false
reactant: MODEL1310110017#

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_2cc97e29_a6b7_42cc_b831_c083dc53c9de
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4023
initial concentration: NaN
is: P06858
type: Species
name: LPL
boundary condition: true

metaM clpn hs c
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00156
is: CHEBI:15589
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CHARGE: 0
name: clpn_hs[c]

metaM HC01376 m
type: Species
has only substance units: false
is: SBO:0000247
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
boundary condition: false
constant: false
is: CHEBI:28692
initial amount: NaN

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM HC00718 c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial amount: NaN
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
constant: false
type: Species
is: SBO:0000247
boundary condition: false

metaR EHGLATm
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_31a4800f_2ac8_4a4e_a244_08453a5f2c3c
is: A0S0A7
is encoded by: hsa:4846
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: NOS3
constant: false

metaM dcdp m
has only substance units: false
initial concentration: 1.0
is: HMDB01245
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
name: dCDP(3-)
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_91a4dd62_51cf_4f37_8122_52aaac0fae42
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4729
constant: false
is: SBO:0000252
type: Species
is: P19404
name: NDUFV2

http://identifiers.org/biomodels.db/MODEL1310110017#_3cb87344_90fe_45b7_889c_6d7516ec66ae
has only substance units: false
constant: false
name: AOC2
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: O75106
is encoded by: hsa:314

metaR MALTSULtm
kinetic law: MODEL1310110017#
reversible: true
modifier: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial

metaR r2346
is described by: ECO:0000000
kinetic law: MODEL1310110017#
fast: false
type: Reaction
reactant: MODEL1310110017#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_9aadd0d7_c420_44a1_b275_01ba1b0fb8b9
is encoded by: hsa:3939
name: LDHA
type: Species
is: P00338
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR PROSTGH2t
fast: false
product: MODEL1310110017#
reversible: true
is: SBO:0000185
name: Prostaglandin H2 transport
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110017#
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176

metaR RE1810M
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reversible: true
name: RE1810
kinetic law: MODEL1310110017#
fast: false
type: Reaction
product: MODEL1310110017#
reactant: MODEL1310110017#

metaM tcynt e
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
type: Species
boundary condition: false
is: CHEBI:18022
name: thiocyanate

metaR UMPK7
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP)
reversible: true
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_e6a70697_162a_4893_9b14_66e852bc43c6
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10400
is: SBO:0000252
initial concentration: NaN
constant: false
name: PEMT

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM dcdp n
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
is: CHEBI:58593
is: HMDB01245
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_93307416_a666_45ee_a1f0_da341567fc70
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: _W74642_1_c
type: Species
is encoded by: hsa:W74642
initial amount: NaN
is: SBO:0000252

metaM prostgd2 e
is: HMDB01403
is: CHEBI:57406
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR GGH 6DHFe
kinetic law: MODEL1310110017#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reactant: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000000

metaM nmn c
boundary condition: false
is: CHEBI:14649
is: SBO:0000247
is: C00455
initial concentration: 1.0
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: NMN
is: HMDB00229

metaM dd2coa m
name: trans-dodec-2-enoyl-CoA(4-)
has only substance units: false
is: HMDB03712
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
initial concentration: 1.0
constant: false

metaM dctp n
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: dCTP
is: HMDB00998
constant: false
is: CHEBI:16311
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458

http://identifiers.org/biomodels.db/MODEL1310110017#_6773148c_c406_4a49_83b6_fd2a91f7a675
boundary condition: true
is encoded by: hsa:6718
is: P51857
type: Species
constant: false
name: AKR1D1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR r0236
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110017#_b166b898_1902_48df_9b95_6ea113c00e5e
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _U37519_1_e
initial amount: NaN
is encoded by: hsa:U37519
type: Species

metaM mescoa m
type: Species
constant: false
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
name: Mesaconyl-CoA
is: C06028
is: CHEBI:27969
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1995
product: MODEL1310110017#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: false
modifier: MODEL1310110017#
type: Reaction

metaM 2mop c
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
is: HMDB01172
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false
boundary condition: false

metaR ALOX52
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
kinetic law: MODEL1310110017#
name: Arachidonate 5-lipoxygenase
modifier: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
reactant: MODEL1310110017#

metaR DAGK hs
reactant: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.107
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110017#
is described by: ECO:0000269

metaM chsterol e
name: cholesterol
initial concentration: 1.0
boundary condition: false
is: CHEBI:16113
has only substance units: false
is: HMDB00067
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
constant: false
initial amount: NaN

metaM HC01712 m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
constant: false
is: CHEBI:28391
name: S-Glutaryldihydrolipoamide
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR Coqe
reversible: true
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
type: Reaction
name: Transport of q10

metaR RE0383C
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110017#
name: RE0383
reversible: true
type: Reaction

metaR PGLYCt
name: phosphatidylglycerol transport
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:

metaM ahcys c
boundary condition: false
constant: false
is: HMDB00939
is: C00021
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
type: Species

metaR PVD3
reactant: MODEL1310110017#
name: Previtamin D3 formation
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_c0cffef2_be80_4576_a427_1f4d4e7b6922
initial amount: NaN
type: Species
is: Q9HCQ5
is encoded by: hsa:50614
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GALNT9
constant: false
has only substance units: false

metaM prostgd2 c
initial amount: NaN
name: prostaglandin D2(1-)
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110017#_f12d4367_8d1c_485d_bb65_5911c7316591
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: NDUFA10
is: SBO:0000252
is: O95299
is encoded by: hsa:4705
initial concentration: NaN
type: Species

metaR r2519
reversible: true
name: Utilized transport
is: SBO:0000185
product: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaR TPI
reversible: true
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is version of: http://identifiers.org/ec-code/5.3.1.1
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
fast: false
product: MODEL1310110017#
is: SBO:0000176
is described by: ECO:0000134
name: triose-phosphate isomerase

metaR r2347
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_9fa2a730_0249_4cdf_8811_6f06e3a948c5
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: O95470
name: SGPL1

http://identifiers.org/biomodels.db/MODEL1310110017#_c32417bb_77ad_4f67_a9f4_ca2378bedbba
initial amount: NaN
is encoded by: hsa:8803
boundary condition: true
has part: E5KS60
type: Species
name: SUCLG1:SUCLA2
has only substance units: false
is: SBO:0000297
initial concentration: NaN
constant: false

metaR PCHOLPg hs
name: choline phosphatase
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
reversible: false
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
product: MODEL1310110017#
is: SBO:0000176

metaR LACZe
reactant: MODEL1310110017#
modifier: MODEL1310110017#
name: b-galactosidase, extracellular
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
product: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.108
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_5fffe8c7_e550_4049_97ab_febeae9c64c5
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6482
name: ST3GAL1
initial amount: NaN
boundary condition: true
is: Q11201
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_1469530a_4d1d_4d9d_a6ac_1a36b559f4a4
name: AICDA
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q546Y9
initial concentration: NaN
type: Species
is encoded by: hsa:57379
constant: false
boundary condition: true

metaR CITt4 4
type: Reaction
is: SBO:0000185
modifier: MODEL1310110017#
name: citrate transport via sodium symport
kinetic law: MODEL1310110017#
product: MODEL1310110017#
is described by: ECO:0000006
reversible: true
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reactant: MODEL1310110017#

metaM lac L e
type: Species
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
is: SBO:0000247
name: (S)-lactate
initial concentration: 1.0
is: HMDB00190
boundary condition: false
is: CHEBI:16651
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110017#_f3fc0636_95bc_45f4_a9cb_81e2e723a84d
boundary condition: true
type: Species
is encoded by: hsa:386757
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: SLC6A10P

metaR r2141
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM chsterol c
constant: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: CHEBI:16113
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00067
name: cholesterol
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_bd5c3f51_401b_421c_b401_3e8ee1e0f68e
is: SBO:0000252
is: Q9H6R3
initial amount: NaN
name: ACSS3
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:79611
initial concentration: NaN

metaR SUCCTD
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM dctp c
name: dCTP
type: Species
initial concentration: 1.0
is: CHEBI:16311
is: HMDB00998
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
constant: false
is: C00458
is: SBO:0000247

metaM 7dhf e
name: heptaglutamyl folate (DHF)
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
is: HMDB06559
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

metaR ALOX5
kinetic law: MODEL1310110017#
type: Reaction
reversible: false
fast: false
name: Arachidonate 5-lipoxygenase
reactant: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.13.11.34
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110017#
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_435e4641_5268_4ea1_b909_95029f448282
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: PEMT
initial concentration: NaN
is encoded by: hsa:10400
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_4cba219a_721f_409b_9684_f784d88abbc8
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI620219
constant: false
has only substance units: false
name: _AI620219_1_e
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_0b6af7a7_285b_488f_9dce_aed6ce553fd2
boundary condition: true
is: Q13825
has only substance units: false
constant: false
type: Species
is encoded by: hsa:549
initial amount: NaN
name: AUH
initial concentration: NaN
is: SBO:0000252

metaR r2142
modifier: MODEL1310110017#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110017#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110017#
product: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM HC00361 c
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58335
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)

metaM HC01434 m
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58931
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false
is: SBO:0000247

metaR r0317
modifier: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110017#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/1.4.4.2
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4

metaR TRPt4
reversible: false
name: L-tryptophan transport in via sodium symport
is described by: ECO:0000304
fast: false
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110017#
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_3f96a73d_a20a_458e_ab9a_de268a8a2253
type: Species
has only substance units: false
initial amount: NaN
name: VNN3:VNN2:VNN1
constant: false
initial concentration: NaN
is encoded by: hsa:55350
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110017#_7d7776c8_5cbf_4331_b315_c9e7a470c25e
is encoded by: hsa:205
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: AK4
constant: false
is: P27144
initial concentration: NaN

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM pail4p hs c
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)

metaM HC02206 e
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
initial amount: NaN
name: prostaglandin C1(1-)
boundary condition: false
is: CHEBI:57399
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110017#_57b70c2a_0493_4b45_831f_0648071cced5
constant: false
is: SBO:0000252
has only substance units: false
name: COX4I1
is: P13073
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1327
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_f3b08553_2129_41c0_b061_c44593d16cf7
is: Q5JWV8
initial amount: NaN
name: ACSL4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2182
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR NAt3 1
product: MODEL1310110017#
fast: false
name: sodium proton antiporter (H:NA is 1:1)
is: SBO:0000185
kinetic law: MODEL1310110017#
is described by: ECO:0000269
modifier: MODEL1310110017#
reactant: MODEL1310110017#
reversible: true
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
type: Reaction

metaR NCNt
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
product: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
is: SBO:0000185
type: Reaction

metaR LYSOXp
is described by: ECO:0000000
fast: false
name: L-lysine oxidase, peroxisomal
reversible: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
kinetic law: MODEL1310110017#
product: MODEL1310110017#
type: Reaction
is: SBO:0000176

metaM tcynt c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18022
is: SBO:0000247
type: Species
name: thiocyanate
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: HMDB01453

metaR PROSTGD2t
reactant: MODEL1310110017#
modifier: MODEL1310110017#
reversible: true
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110017#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110017#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_a3f97172_1124_46be_b90c_644d2396d3c6
has only substance units: false
boundary condition: true
is encoded by: hsa:27068
initial amount: NaN
name: PPA2
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_52b5a9b4_8e44_4225_9853_da59387f6ea6
is encoded by: hsa:4724
has only substance units: false
is: O43181
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: NDUFS4

http://identifiers.org/biomodels.db/MODEL1310110017#_de642aca_35fb_429f_9667_a5e2956b1c1c
is encoded by: hsa:9498
initial amount: NaN
constant: false
initial concentration: NaN
is: E7EML0
has only substance units: false
boundary condition: true
name: SLC4A8
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_9633fd1f_6e10_4ab4_b9d9_0329c045c517
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: P05091
name: ALDH2
is encoded by: hsa:217
has only substance units: false
boundary condition: true

metaR UMPK6n
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_04ce7601_9b22_4d42_b273_0928ea1d381e
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI640625
name: _AI640625_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_f152b4b8_5b1d_42a0_a72c_e57ad96f11e9
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:BC005314
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: _BC005314_1_x

http://identifiers.org/biomodels.db/MODEL1310110017#_f95f91bc_4cee_4ed8_ab79_4f99909db838
is encoded by: hsa:56474
name: CTPS2
initial concentration: NaN
is: Q9NRF8
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_bf246519_7f0c_495b_a864_e7810cd8e7a1
is: Q15392
has only substance units: false
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
initial amount: NaN
name: DHCR24
initial concentration: NaN
constant: false
type: Species

metaR r1611
fast: false
reactant: MODEL1310110017#
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110017#
is: SBO:0000185
is described by: ECO:0000000

metaM ptth m
constant: false
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
is: HMDB03426
initial concentration: 1.0
boundary condition: false
name: pantetheine
type: Species
is: CHEBI:16753
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c77e0016_8921_4147_96e6_faf767518711
name: _AA576959_1_c
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AA576959

metaM HC02206 c
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
constant: false
type: Species
name: prostaglandin C1(1-)
is: SBO:0000247

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r2140
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is: SBO:0000185
product: MODEL1310110017#
modifier: MODEL1310110017#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GTHPe
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase (e)
kinetic law: MODEL1310110017#
fast: false
product: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110017#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110017#_6dc616bc_4a13_406a_8c9c_d17578ee7217
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA502753
initial amount: NaN
name: _AA502753_1_m
constant: false
type: Species

metaR 5ADTSTSTERONEte
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110017#
product: MODEL1310110017#
fast: false
reversible: true
name: 5 alpha dihydrotesterone transport

metaR SPC HSt
reactant: MODEL1310110017#
is described by: ECO:0000000
kinetic law: MODEL1310110017#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reversible: true
fast: false
name: sphingosylphosphorylcholine transport (diffusion)
is: SBO:0000185
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_7a539e18_cb86_49e8_ae43_842e46d0524e
name: NT5C2
is encoded by: hsa:22978
is: SBO:0000252
is: P49902
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR r1610
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
product: MODEL1310110017#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110017#_61b46b58_11e8_4144_8b26_544dbd912628
is: SBO:0000252
has only substance units: false
name: H6PD
is: O95479
is encoded by: hsa:9563
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_e21dea16_af1f_4d87_8110_c14b49d5363f
is encoded by: hsa:7296
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: TXNRD1
has only substance units: false
type: Species

metaR TCYNTt
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
kinetic law: MODEL1310110017#
product: MODEL1310110017#
reversible: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
modifier: MODEL1310110017#
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110017#_686fae32_0a8c_4656_9da9_f9d9a7e6669a
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q99884
is encoded by: hsa:6534
name: SLC6A7
is: SBO:0000252
has only substance units: false

metaR FMNAT
kinetic law: MODEL1310110017#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
product: MODEL1310110017#
is described by: ECO:0000134
reactant: MODEL1310110017#
name: FMN adenylyltransferase
modifier: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110017#_59c0601d_a141_4a4a_9b27_620aad8214d7
type: Species
initial amount: NaN
name: MTMR1
is: SBO:0000252
is encoded by: hsa:8776
boundary condition: true
initial concentration: NaN
is: Q13613
has only substance units: false
constant: false

metaR DCK2n
fast: false
type: Reaction
reactant: MODEL1310110017#
is described by: ECO:0000269
reversible: true
product: MODEL1310110017#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM crn m
has only substance units: false
is: HMDB00062
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16347
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine

metaM cholate e
type: Species
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
initial amount: NaN
is: HMDB00619
boundary condition: false
constant: false
name: Cholate
is: SBO:0000247
has only substance units: false

metaM andrstrn r
has only substance units: false
initial amount: NaN
is: CHEBI:16032
type: Species
is: HMDB00031
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
constant: false
initial concentration: 1.0
name: androsterone
boundary condition: false

metaM ksii core2 deg3 l
name: keratan sulfate II (core 2-linked), degradation product 3
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0

metaM 2mop m
type: Species
is: HMDB01172
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
is: CHEBI:57700
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_c9eb81f1_21d1_4835_82de_f2912b98462c
initial amount: NaN
is encoded by: hsa:9167
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: COX7A2L
is: Q6FGA0
type: Species

metaM L2aadp6sa c
has only substance units: false
name: L-allysine
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
constant: false
is: CHEBI:17917
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_e75ef7ff_eb4e_4599_bf80_9572199b33f8
is encoded by: hsa:AI934540
type: Species
name: _AI934540_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110017#_1f49bb64_8069_4fd8_a098_7a872c910572
is encoded by: hsa:2180
has only substance units: false
is: SBO:0000252
type: Species
name: ACSL1
boundary condition: true
initial amount: NaN
is: P33121
initial concentration: NaN
constant: false

metaR ASCBt4
kinetic law: MODEL1310110017#
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110017#
name: L-ascorbate transport via proton symport
product: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000269

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR r1778
modifier: MODEL1310110017#
type: Reaction
fast: false
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110017#
kinetic law: MODEL1310110017#

metaR DDPGAm
product: MODEL1310110017#
reversible: true
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110017#
type: Reaction

metaR r1109
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
product: MODEL1310110017#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110017#_fb48654e_9107_4e76_b0a2_c0db33f86d0d
is: Q7Z725
name: SLC34A1
initial amount: NaN
is encoded by: hsa:6569
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_9566f044_c219_4825_b4bd_558d8da63f18
is encoded by: hsa:4907
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NT5E
constant: false
type: Species
is: P21589

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM CE2431 m
initial concentration: 1.0
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
is: C01936
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110017#_d1af498f_80f4_403e_91ff_e3573950124c
has only substance units: false
initial amount: NaN
type: Species
name: NDUFB11
boundary condition: true
is: Q9NX14
initial concentration: NaN
is encoded by: hsa:54539
constant: false
is: SBO:0000252

metaR SPHK21c
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
reactant: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
modifier: MODEL1310110017#
name: sphingosine kinase 2

metaM cgly c
constant: false
is: CHEBI:4047
has only substance units: false
name: L-cysteinylglycine
is: HMDB00078
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: SBO:0000247

metaR RDH1a
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
fast: false
name: retinol dehydrogenase (all-trans,NADPH)
is described by: ECO:0000269
reactant: MODEL1310110017#
is: SBO:0000176
product: MODEL1310110017#
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110017#
reversible: true

metaR FUMAC
kinetic law: MODEL1310110017#
name: fumarylacetoacetase
is version of: http://identifiers.org/ec-code/3.7.1.2
fast: false
product: MODEL1310110017#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110017#
reactant: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_75a241cf_cd8c_4f4c_90c7_3851659e61db
is: Q9NWU1
is encoded by: hsa:54995
name: OXSM
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110017#_04af96dc_3991_43ef_b0db_150edebe22ff
initial concentration: NaN
has only substance units: false
name: PPA2
constant: false
is: F8WDN9
initial amount: NaN
is encoded by: hsa:27068
type: Species
boundary condition: true
is: SBO:0000252

metaR SUCOASm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110017#
kinetic law: MODEL1310110017#
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
reactant: MODEL1310110017#
modifier: MODEL1310110017#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110017#_698e43c7_1c13_4cf3_9c25_3c74af3a8735
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:55229
name: PANK4
is: Q9NVE7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110017#_499b2d8a_f208_44ab_a994_f9b7d79816e2
type: Species
name: FOLR1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110017#_bb53ff1f_a5f1_45c9_bdb6_6bb7211aacc6
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10400
name: PEMT
type: Species
has only substance units: false
is: SBO:0000252

metaR DM Lcystin
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR GGH 6DHFl
is described by: ECO:0000000
reactant: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110017#
kinetic law: MODEL1310110017#
type: Reaction
reversible: false
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110017#

metaM CE5853 e
is: SBO:0000247
name: alpha-CEHC-glucuronide
type: Species
initial concentration: 1.0
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
constant: false
has only substance units: false
boundary condition: false
is: HMDB00127
initial amount: NaN
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110017#_76e7ede8_f9b7_44a0_9f04_fd6fada0f5ac
is: SBO:0000252
is encoded by: hsa:7371
type: Species
boundary condition: true
constant: false
name: UCK2
is: Q9BZX2
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM mlthf m
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
is: HMDB01533
is: C00143
is: CHEBI:15636
initial concentration: 1.0
type: Species
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
constant: false

metaM lac L c
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
is: CHEBI:16651
is: HMDB00190
is: SBO:0000247
type: Species
name: (S)-lactate
initial concentration: 1.0
constant: false

metaR 1PPDCRp
type: Reaction
reactant: MODEL1310110017#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
reversible: false
kinetic law: MODEL1310110017#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false

metaR r0051
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110017#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110017#
is described by: ECO:0000000
modifier: MODEL1310110017#
product: MODEL1310110017#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is version of: http://identifiers.org/ec-code/3.1.3.5

http://identifiers.org/biomodels.db/MODEL1310110017#_f1de8078_c66d_4aee_aa50_a63fbb218162
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AI653169_1_c
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AI653169
boundary condition: true

metaM fadh2 x
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01197
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58307

http://identifiers.org/biomodels.db/MODEL1310110017#_471c3259_4834_409d_87ca_11225e15b9c5
is encoded by: hsa:51166
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: AADAT
type: Species
boundary condition: true
is: Q4W5N8

metaM dcdp c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: C00705
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: dCDP
is: HMDB01245

metaM glyc R m
is: SBO:0000247
name: D-glycerate
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16659
boundary condition: false
type: Species
constant: false

metaR r1088
product: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
fast: false
reversible: true
is: SBO:0000185
name: Active transport
type: Reaction
is described by: ECO:0000000

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR PItn
fast: false
is: SBO:0000185
kinetic law: MODEL1310110017#
reactant: MODEL1310110017#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
name: phosphate transport, nuclear
product: MODEL1310110017#

http://identifiers.org/biomodels.db/MODEL1310110017#_c1cd5f9a_4bf5_49f2_a881_4b13a0c6b931
name: _X63359_1_c
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:X63359
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_0a8b37d3_0cac_40dc_8374_3d5a24ba0831
is encoded by: hsa:1103
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CHAT
type: Species
is: Q6LEN5

metaM ppcoa x
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00100
name: Propanoyl-CoA
boundary condition: false
type: Species
is: HMDB01275

metaR DNDPt8m
product: MODEL1310110017#
modifier: MODEL1310110017#
is: SBO:0000185
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
is described by: ECO:0000269
name: dADP transport via dUDP antiport
kinetic law: MODEL1310110017#
fast: false

metaM cgly e
has only substance units: false
name: L-cysteinylglycine
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

http://identifiers.org/biomodels.db/MODEL1310110017#_5d5d229b_186e_4822_9d41_cb0a6c4ffcab
is encoded by: hsa:6582
type: Species
initial concentration: NaN
boundary condition: true
name: SLC22A2
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110017#_1a1d3dc3_28a7_4139_99b3_acad643a38a7
is: SBO:0000252
name: GMPPB
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:29925

metaR r1779
reactant: MODEL1310110017#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110017#
product: MODEL1310110017#
kinetic law: MODEL1310110017#
fast: false
reversible: false
is: SBO:0000185
type: Reaction