metaM atp x
boundary condition: false
is: C00002
name: ATP(4-)
is: SBO:0000247
is: CHEBI:57299
constant: false
has only substance units: false
is: HMDB00538
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_0c80aaa8_cc64_4cc7_8e3c_62a32ddb6f76
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: PPA1
is: Q15181
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5464
initial amount: NaN

metaM 7dhchsterol c
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
is: HMDB00032
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR CRNt
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
name: L-carnitine reversible transport
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaR FRDPtc
reversible: true
kinetic law: MODEL1310110016#
fast: false
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110016#

metaR SBT Dtde
reversible: true
name: D-sorbitol transport, extracellular
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
type: Reaction

metaR CORE6GTg
modifier: MODEL1310110016#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110016#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus

metaM acgpail hs c
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57265
constant: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_49ff7bc8_38f9_485a_b3e3_72c73edc1856
name: _U37519_1_c
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM dudp n
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
constant: false
name: dUDP(3-)
is: CHEBI:60471
initial concentration: 1.0
type: Species
is: HMDB01000
has only substance units: false

metaM cdpea c
name: cdpea[c]
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57876
boundary condition: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
has only substance units: false
is: HMDB01564
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_fd4c2978_92cc_4706_9901_f88b93d822f6
has only substance units: false
boundary condition: true
is: Q9NUB1
constant: false
initial amount: NaN
name: ACSS1
is encoded by: hsa:84532
type: Species
initial concentration: NaN
is: SBO:0000252

metaM glx c
has only substance units: false
initial concentration: 1.0
is: HMDB00119
initial amount: NaN
boundary condition: false
is: CHEBI:36655
name: glyoxylate
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
is: SBO:0000247

metaR B3GALTg
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Beta galactosyltransferase
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
reversible: false
fast: false
kinetic law: MODEL1310110016#

metaM ala D e
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial amount: NaN
has only substance units: false
is: CHEBI:15570
is: HMDB01310
boundary condition: false
type: Species
initial concentration: 1.0
name: D-alanine

metaR PHCHGSm
reversible: true
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_87c089ac_0fc2_468f_af9a_1d2cb0feda20
constant: false
type: Species
is encoded by: hsa:1384
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CRAT

metaM 3snpyr c
initial amount: NaN
is: HMDB02332
constant: false
boundary condition: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
type: Species
is: CHEBI:1665
is: SBO:0000247
initial concentration: 1.0
name: 3-Sulfinopyruvate
has only substance units: false

metaR 5ADTSTSTERONESte
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110016#
name: sulfonated testosterone transport
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM pcreat m
name: N-phosphocreatinate(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58092
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
is: HMDB01511

metaM ocdca e
has only substance units: false
name: octadecanoate (n-C18:0)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
is: HMDB00827
is: CHEBI:25629
boundary condition: false
is: C01530
initial amount: NaN

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_e9cbadb4_8802_413f_921b_2fcca89e046b
is encoded by: hsa:2653
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: GCSH
is: P23434
boundary condition: true
initial amount: NaN
has only substance units: false

metaR PRISTCOAtx
name: pristcoa peroxisomal transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000

metaR r0741
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110016#
fast: false
reversible: true

metaM fucfucgalacglcgalgluside hs e
type: Species
is: CHEBI:15824
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Leb glycolipid
is: SBO:0000247
is: C00095
is: HMDB00660
constant: false
boundary condition: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110016#_2e65b3ac_9d17_4c0e_a85a_f51a21e998e5
initial concentration: NaN
constant: false
is: H7C5B8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4708
boundary condition: true
name: NDUFB2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_fd673caa_6b2d_4004_85f0_c8863efed304
is encoded by: hsa:22978
name: NT5C2
is: P49902
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM 3ohdcoa m
constant: false
name: 3-oxopalmitoyl-CoA(4-)
is: SBO:0000247
type: Species
is: CHEBI:57349
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
has only substance units: false
is: HMDB06402
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_58bb0c9f_86fc_4bcc_b29a_420390bf09dc
name: ATP1A1:ATP1B3
is: SBO:0000297
is encoded by: hsa:476
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:483
has part: B7Z3U6
type: Species
has only substance units: false
has part: P54709

metaR CERT2rt
is: SBO:0000185
reversible: true
product: MODEL1310110016#
fast: false
name: ceramide transport protein
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaM hs deg14 l
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
name: heparan sulfate, degradation product 14
boundary condition: false
type: Species
is: CHEBI:16126
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR S6TASE21ly
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000176

metaM o2s x
initial amount: NaN
type: Species
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
name: superoxide
initial concentration: 1.0
constant: false
is: HMDB02168
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_8092a692_99fc_4d55_bf1a_a1a3fe50ff8c
is: P52790
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3101
is: SBO:0000252
boundary condition: true
constant: false
name: HK3

metaR BILIRUBt2
type: Reaction
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000269
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_19cd74d1_d9d4_4e40_834c_1b89be1e1ca3
constant: false
has only substance units: false
is: O95167
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4696
name: NDUFA3
initial amount: NaN
type: Species
is: SBO:0000252

metaR GGH 5THFe
name: Gamma-glutamyl hydrolase (5THF), extracellular
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_22415083_4bcc_4ece_991b_616dff4640ca
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:10610
constant: false
is: Q9UJ37
initial concentration: NaN
name: ST6GALNAC2
is: SBO:0000252

metaM fru e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: D-Fructose
is: HMDB00660
is: CHEBI:15824
is: SBO:0000247

metaM etha c
initial concentration: 1.0
is: HMDB00149
initial amount: NaN
name: etha[c]
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: CHEBI:57603

http://identifiers.org/biomodels.db/MODEL1310110016#_680b028b_0125_4415_9f2b_4a0dda316ee1
type: Species
name: HK1
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q59FD4
is encoded by: hsa:3098
constant: false
initial concentration: NaN

metaR UGCG
fast: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
name: Ceramide glucosyltransferase
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.80
product: MODEL1310110016#
modifier: MODEL1310110016#

metaM bilglcur e
initial amount: NaN
constant: false
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM pi n
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: HMDB00973
is: CHEBI:43474
is: SBO:0000247
name: hydrogenphosphate

metaM xoltetrol m
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial concentration: 1.0
is: CHEBI:17278

metaR GALASE13ly
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110016#
name: beta-galactosidase, lysosomal
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_421121a5_445e_4911_b1f6_7ee6f9fcaf71
is: P23368
name: ME2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4200

http://identifiers.org/biomodels.db/MODEL1310110016#_6f6a8841_6e01_4776_bc7a_65a33ca21f65
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q6P1K9
has only substance units: false
name: PANK2
type: Species
constant: false
is encoded by: hsa:80025
boundary condition: true

metaR DM core5 g
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM core5(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_c7cceb81_c9f7_4134_9336_93dcccab84d9
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9Y6M9
name: NDUFB9
constant: false
initial amount: NaN
is encoded by: hsa:4715

http://identifiers.org/biomodels.db/MODEL1310110016#_1da2a74e_3fa0_4aeb_a9e0_800d4a2b4e24
is encoded by: hsa:4842
name: NOS1
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: B4DG68

metaR CYSTA
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
name: cysteine transaminase
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_3fec0548_21da_4086_b550_5a40ef7d417a
is encoded by: hsa:6536
name: SLC6A9
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: B7Z3W8
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_bdfe19cd_0de7_4e42_b125_4664faf5e592
is encoded by: hsa:55229
is: SBO:0000252
has only substance units: false
constant: false
name: PANK4
boundary condition: true
initial amount: NaN
is: Q9NVE7
type: Species
initial concentration: NaN

metaM itp c
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: ITP(3-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
is: CHEBI:57614

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR PMANM
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.4.2.8
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.4.2.2
reactant: MODEL1310110016#
type: Reaction
name: phosphomannomutase
reversible: true
is: SBO:0000176

metaR r2509
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_5fde3a52_0a12_458f_92c5_580c527bb8b3
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: SLC6A2
initial concentration: NaN
type: Species
is: Q96KH8
is encoded by: hsa:6530
is: SBO:0000252

metaM dudp m
has only substance units: false
is: CHEBI:60471
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
initial amount: NaN
name: dUDP(3-)
type: Species
is: HMDB01000
constant: false
boundary condition: false

metaM pi m
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
type: Species
has only substance units: false
is: CHEBI:43474
initial amount: NaN
is: C00009
name: hydrogenphosphate
constant: false
initial concentration: 1.0
boundary condition: false

metaM ksii core2 e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00211
constant: false
is: CHEBI:17268
name: keratan sulfate II (core 2-linked)

metaM fucfucgalacglcgalgluside hs g
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00174
type: Species
name: Leb glycolipid
boundary condition: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:18287
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8c63a43f_ea81_4da8_b952_6b2c3bbf2126
is encoded by: hsa:2821
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P06744
name: GPI
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_4285c9b8_dab7_44d5_b21c_834d6f13878e
initial amount: NaN
is encoded by: hsa:1633
initial concentration: NaN
boundary condition: true
type: Species
name: DCK
is: SBO:0000252
constant: false
is: P27707
has only substance units: false

metaR RE0453N
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: RE0453
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110016#
fast: false

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial concentration: 1.0
is: HMDB00660
name: D-Fructose
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00095
type: Species
is: CHEBI:15824
is: SBO:0000247
constant: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM bilglcur c
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM val L m
is: CHEBI:16414
constant: false
name: L-valine
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00883

http://identifiers.org/biomodels.db/MODEL1310110016#_5e3d1b79_debe_49e7_9c98_160e75f8632b
boundary condition: true
initial concentration: NaN
is encoded by: hsa:956
has only substance units: false
type: Species
name: ENTPD3
is: SBO:0000252
initial amount: NaN
is: O75355
constant: false

metaR 4ABUTtcn
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
type: Reaction
reversible: false
name: transport of GABA
is described by: ECO:0000134
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
reactant: MODEL1310110016#

metaR RE0453M
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
name: RE0453
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110016#

metaM nad x
is: http://identifiers.org/pubchem.compound/3305
is: C00003
name: Nicotinamide adenine dinucleotide
is: HMDB00902
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57540
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_72cd27f4_bc9f_4d2e_a527_e3fbcf961304
name: ATP5A1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is: A8K092
is encoded by: hsa:498

metaM ksi deg22 l
is: CHEBI:16953
type: Species
is: SBO:0000247
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 22
is: HMDB00812
boundary condition: false

metaR GLYt7 211 r
is: SBO:0000185
reactant: MODEL1310110016#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110016#

metaM hs deg19 l
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
initial amount: NaN
constant: false
is: HMDB06254
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 19

http://identifiers.org/biomodels.db/MODEL1310110016#_8d78d4f9_1036_4446_bf8b_38586639eede
boundary condition: true
has only substance units: false
is: P30613
initial amount: NaN
is: SBO:0000252
constant: false
name: PKLR
type: Species
initial concentration: NaN
is encoded by: hsa:5313

metaM aicar e
initial concentration: 1.0
has only substance units: false
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: C04677
is: CHEBI:58475
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaM creat e
name: creatine
is: HMDB00064
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
is: CHEBI:16919

http://identifiers.org/biomodels.db/MODEL1310110016#_5acfb98e_eeb3_494d_8201_6e391670cbfa
type: Species
initial amount: NaN
is encoded by: hsa:1337
name: COX6A1
initial concentration: NaN
has only substance units: false
is: P12074
boundary condition: true
is: SBO:0000252
constant: false

metaR FUMtm
reversible: true
product: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
fast: false
type: Reaction
name: fumarate transport, mitochondrial

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR PGI
name: glucose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110016#
is described by: ECO:0000134
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
is: SBO:0000176
reactant: MODEL1310110016#
fast: false

metaR SO4t4 2
reactant: MODEL1310110016#
name: sulfate transport via sodium symport
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_cf46faad_93e6_4729_9634_6f85c986c80f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: NDUFA12
is: F8VQS7
boundary condition: true
type: Species
is encoded by: hsa:55967
constant: false

metaR HSAT2ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
reactant: MODEL1310110016#

metaR RE3006M
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3006
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110016#
is described by: ECO:0000000

metaR GPAM hs
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: glycerol-3-phosphate acyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.15
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110016#
is described by: ECO:0000000
reversible: false
product: MODEL1310110016#

metaM gar c
constant: false
type: Species
boundary condition: false
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
is: C03838
is: HMDB02022
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_7e5ebe6a_6368_40ed_9f59_5eddedb7a6dc
boundary condition: true
has only substance units: false
name: GPX1
type: Species
is encoded by: hsa:2876
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaR DALAOXx
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.3
notes: GENE_ASSOCIATION: (1610.1) SUBSYSTEM: D-alanine metabolism EC Number: 1.4.3.3 Confidence Level: 4 AUTHORS: PMID:9153402 NOTES:SAB
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
name: D-Alanine Oxidase (x)
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_7c3e240e_79f6_41c5_afe6_7d58a267e4d3
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: FPGT
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O14772
is encoded by: hsa:8790

metaM core6 l
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
boundary condition: false
constant: false
initial amount: NaN
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
has only substance units: false

metaR ASPGLUm
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
fast: false
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
is: SBO:0000185

metaM crn m
has only substance units: false
initial amount: NaN
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: C00318
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00062
type: Species
name: L-Carnitine

http://identifiers.org/biomodels.db/MODEL1310110016#_df3d68bd_8eb5_49a5_b59a_7bb93178e479
name: DAO
is encoded by: hsa:1610
constant: false
boundary condition: true
has only substance units: false
type: Species
is: P14920
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110016#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport

metaM CE2866 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:45698
is: SBO:0000247
name: 3,3'-diiodo-L-thyronine
notes: FORMULA: C15H13I2NO4 CHARGE: 0 INCHI: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1 EHMN_ABBREVIATION: CE2866
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_13df5fdd_4624_4288_aa2a_46ebd4bf4bde
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: Q6LEN6
initial concentration: NaN
name: CHAT
type: Species
is encoded by: hsa:1103
initial amount: NaN

metaM utp n
name: UTP(4-)
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: HMDB00285
is: CHEBI:46398

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Choline kinase
modifier: MODEL1310110016#

metaR BHBt
fast: false
product: MODEL1310110016#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaM rbt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
is: HMDB00508
constant: false
has only substance units: false
is: CHEBI:15963
is: SBO:0000247
boundary condition: false
name: D-ribitol
initial amount: NaN
initial concentration: 1.0

metaM ala D c
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:15570
initial concentration: 1.0
is: HMDB01310
name: D-alanine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_9b7553a9_8648_4bbd_b0c5_fe2e1914181f
boundary condition: true
type: Species
is encoded by: hsa:11136
name: SLC7A9
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P82251
initial amount: NaN

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaM tcynt c
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: thiocyanate
has only substance units: false
is: CHEBI:18022
boundary condition: false

metaR R group phosphotase 1
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: R group phosphotase 1
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_aa2d4413_5db3_4d1e_9b0b_8f9834c2000e
initial amount: NaN
boundary condition: true
is encoded by: hsa:137872
name: ADHFE1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8IWW8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_83ff303f_04ac_4c32_821a_24e8ea33392a
is encoded by: hsa:2348
name: FOLR1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR F1Atg
name: F1alpha transport (from golgi to lysosome)
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR DURAD2
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.3.1.2

metaR 3MOBte
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#

metaM ser D e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
boundary condition: false
initial concentration: 1.0
is: HMDB03406
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: D-serine

metaR r1906
reversible: false
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_d11cf3bf_43ba_4d99_a8b5_5059cf2866a6
name: SLC25A18
initial concentration: NaN
initial amount: NaN
is: Q9H1K4
is encoded by: hsa:83733
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_0e6d3acb_de6d_4b9b_b4ea_816a1c039206
is: SBO:0000297
has part: F8W7V3
type: Species
is encoded by: hsa:517
has only substance units: false
is encoded by: hsa:9551
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
boundary condition: false
is: CHEBI:58178
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_89a900be_9de9_41f1_8a04_159168474ab8
is: Q5QPH3
constant: false
name: ACSS2
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55902

metaM arachdcoa c
initial concentration: 1.0
is: HMDB06523
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: arachidonoyl-CoA(4-)
has only substance units: false

metaM h2o r
is: SBO:0000247
name: H2O
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB02111
boundary condition: false
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_83da58c5_2859_48bb_8481_9a35cb48f6a8
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10786
initial amount: NaN
name: SLC17A3
is: O00476

metaM pristcoa c
type: Species
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
name: pristanoyl coa
constant: false
is: SBO:0000247
is: CHEBI:51341
initial amount: NaN
has only substance units: false

metaR R group phosphotase 2
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 2
product: MODEL1310110016#

metaR PGK
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.2.3
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: phosphoglycerate kinase
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110016#_0577eed3_c9d1_4a01_a549_dcae8b7b7c44
type: Species
is encoded by: hsa:2525
is: P21217
boundary condition: true
initial amount: NaN
has only substance units: false
name: FUT3
constant: false
initial concentration: NaN
is: SBO:0000252

metaM tcynt e
initial amount: NaN
name: thiocyanate
initial concentration: 1.0
is: CHEBI:18022
constant: false
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
is: HMDB01453
is: SBO:0000247
has only substance units: false

metaM rbt e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
boundary condition: false
is: HMDB00508
has only substance units: false
constant: false
is: CHEBI:15963
name: D-ribitol

metaM stcoa c
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: Stearoyl-CoA (n-C18:0CoA)
is: CHEBI:57394
is: C00412
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114

metaM glygly e
notes: FORMULA: C4H8N2O3 CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB11733
name: Glycyl-glycine
is: C02037
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM mi145p c
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB01498
is: CHEBI:203600
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245

http://identifiers.org/biomodels.db/MODEL1310110016#_34d434cc_e0cd_4768_b8d0_cd2217d665c7
initial concentration: NaN
name: NDUFS3
has only substance units: false
is encoded by: hsa:4722
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: O75489
type: Species

metaM dd2coa m
constant: false
boundary condition: false
is: SBO:0000247
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57330
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_094c0857_0ac5_4a8b_8609_bc3527495feb
is: SBO:0000252
is encoded by: hsa:1757
name: SARDH
is: A8K596
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_1a9e9d50_cfa2_419d_97f6_26728fd3ca43
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:9583
has only substance units: false
is: Q9Y227
name: ENTPD4
initial concentration: NaN

metaR 6HTSTSTERONEte
is: SBO:0000185
fast: false
name: hydroxylated testosterone transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone needs to be exported NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#

metaR r1585
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pi x
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
is: HMDB00973
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0
has only substance units: false

metaR FATP2t
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110016#
is described by: ECO:0000269
name: fatty acid electroneutral transport
modifier: MODEL1310110016#

metaR r1619
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_bb7118cf_e09d_41fa_ae57_8d0339495e04
name: ALDH3B2
is encoded by: hsa:222
constant: false
is: P48448
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM tdcoa c
is: HMDB01521
is: C02593
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
type: Species
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
is: CHEBI:57385
boundary condition: false

metaM leugly e
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: Leucylglycine
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_95335a8f_f03a_4758_8712_14eec0264ff6
is encoded by: hsa:2878
name: GPX3
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P22352

metaM g6p r
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01401
is: CHEBI:61548
constant: false
is: C00092

metaR r0129
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
modifier: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ea23cc20_da65_4bad_81f0_6385c806b902
initial amount: NaN
name: NDUFA10
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O95299
is encoded by: hsa:4705
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_b256063e_6e1c_4add_a265_3583e9da71c1
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: ALAS1
is: P13196
is: SBO:0000252
is encoded by: hsa:211

http://identifiers.org/biomodels.db/MODEL1310110016#_2ed14ff9_fdfa_4499_823f_5a70bf363b72
is encoded by: hsa:197257
initial concentration: NaN
type: Species
is: Q86WU2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: LDHD

http://identifiers.org/biomodels.db/MODEL1310110016#_80d1078e_3d89_4eec_a236_80894eda690b
initial concentration: NaN
name: ACOT1
is: SBO:0000252
boundary condition: true
is: E9KL42
initial amount: NaN
is encoded by: hsa:641371
constant: false
has only substance units: false
type: Species

metaM gsn e
initial amount: NaN
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: CHEBI:16750
is: C00387
type: Species
is: SBO:0000247
is: HMDB00133
initial concentration: 1.0
boundary condition: false
name: Guanosine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_893ac1c5_2507_4a03_8d9f_c20d82091bd2
has only substance units: false
is encoded by: hsa:9843
type: Species
constant: false
initial concentration: NaN
name: HEPH
is: E9PHN8
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d7d6b45d_d4f3_4292_9e5e_db3d7e68607a
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4967
is: B4E3E9
name: OGDH

http://identifiers.org/biomodels.db/MODEL1310110016#_def1862b_baf4_4d86_ade7_4a27e0ce11b4
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: KL
constant: false
is encoded by: hsa:9365
initial concentration: NaN
is: Q9UEF7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_396a0b00_913b_47fc_be1d_8c54cb328273
boundary condition: true
has only substance units: false
name: HADHB
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3032
type: Species
constant: false
initial concentration: NaN
is: P55084

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1ae51427_8945_48ef_b86c_687f148ececd
has only substance units: false
initial concentration: NaN
constant: false
is: P48448
type: Species
name: ALDH3B2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110016#_6a13a4f3_e11f_404a_832b_7da8ac733d0f
initial amount: NaN
is: SBO:0000252
name: EHHADH
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: Q9NY65
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110016#_a078fe87_9de4_489c_94e5_8565e6e39bce
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _C7orf24_1_m
boundary condition: true
is encoded by: hsa:C7orf24
constant: false
initial amount: NaN

metaR r1586
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM HC02203 e
name: prostaglandin-a2
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27820

metaR r1618
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaM xol7ah3 c
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28540
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
boundary condition: false
is: HMDB12455
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false

metaM core6 g
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110016#_cede2fcb_3f02_4d5f_b760_8766cea34d83
name: MCCC1:MCCC2
boundary condition: true
has part: Q96RQ3
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:64087
has part: Q9HCC0
initial amount: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:56922

metaR r0842
name: Postulated transport reaction
product: MODEL1310110016#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:

metaM utp e
initial concentration: 1.0
boundary condition: false
is: CHEBI:46398
has only substance units: false
name: UTP(4-)
type: Species
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
initial amount: NaN
is: HMDB00285

metaR r0494
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaR TKT2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: transketolase
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reversible: true
fast: false
reactant: MODEL1310110016#

metaM thp2c c
name: 1-piperideine-6-carboxylate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
initial concentration: 1.0
is: HMDB12130
is: CHEBI:16987
has only substance units: false
constant: false
initial amount: NaN

metaM ksii core2 l
is: HMDB01644
boundary condition: false
is: CHEBI:17140
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM nad r
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: NAD(1-)
is: HMDB00902
initial concentration: 1.0
has only substance units: false
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110016#_bb39b8ab_09e3_41a4_824d_b779647b3989
initial amount: NaN
name: DGKI
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: O75912
is: SBO:0000252
is encoded by: hsa:9162

metaM CE2431 m
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: CHEBI:57795
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: cis-deca-4-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110016#_4ca99280_26a4_4420_ac69_fbd235d8793e
constant: false
has part: P48728
is encoded by: hsa:2653
is encoded by: hsa:2731
boundary condition: true
has only substance units: false
initial concentration: NaN
has part: P23434
is encoded by: hsa:275
is: SBO:0000297
initial amount: NaN
type: Species
has part: P23378
name: DLD:GCSH:GLDC:AMT

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_25125877_7c66_472f_9a0d_f53e474138e8
is encoded by: hsa:80055
type: Species
is: Q75T13
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: PGAP1
boundary condition: true

metaM creat c
name: creatine
is: HMDB00064
is: CHEBI:16919
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM pcreat c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB01511
boundary condition: false
notes: FORMULA: C4H9N3O5P CHARGE: -1 INCHI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)/p-2 EHMN_ABBREVIATION: C02305
is: CHEBI:58092
name: N-phosphocreatinate(2-)

http://identifiers.org/biomodels.db/MODEL1310110016#_fb95f0e9_7fe0_4752_bf14_cc9ab77b0a5b
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA629629
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: _AA629629_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_05b826bb_2bd8_4b94_8720_ed5c4787e352
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: _AI091231_1_c
boundary condition: true
is encoded by: hsa:AI091231

metaM crn r
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: SBO:0000247
name: (R)-carnitine
is: CHEBI:16347
is: HMDB00062
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_889db78f_c64b_4e94_84c3_c10c43118575
is: SBO:0000252
is: Q86YI5
is encoded by: hsa:1737
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: DLAT
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_545988cd_5a88_431b_a1c6_17330e2f500e
initial amount: NaN
constant: false
is: P54803
initial concentration: NaN
name: GALC
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:2581
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cc3ced65_9253_4ab0_8d7c_0480e527124c
name: GALNT10
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:55568
constant: false
is: Q86SR1
initial amount: NaN
boundary condition: true
has only substance units: false

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110016#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid

http://identifiers.org/biomodels.db/MODEL1310110016#_edc1e9dd_2ea9_4c08_8aa7_0fc8e1b2fff8
initial concentration: NaN
type: Species
initial amount: NaN
is: P24311
constant: false
name: COX7B
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1349
boundary condition: true

metaR TKT1
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: transketolase
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_f722258e_b1ac_47a9_9b33_0a4707a27bfa
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: DPM2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8818
is: SBO:0000252

metaM xoltetrol c
is: CHEBI:17278
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
has only substance units: false
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
initial amount: NaN
is: HMDB01231

http://identifiers.org/biomodels.db/MODEL1310110016#_1f792f28_97fd_48aa_adab_ecf88262b7e6
is: Q9NYR8
type: Species
name: RDH8
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:50700

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#

metaM utp c
constant: false
name: UTP
is: CHEBI:46398
is: SBO:0000247
boundary condition: false
is: HMDB00285
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
is: C00075
initial concentration: 1.0
initial amount: NaN

metaM cdpdag hs m
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58332
initial amount: NaN
name: CDP-diacylglycerol(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078

metaM HC02203 c
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27820
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_cd9332b4_8e8d_4cd1_977b_70db4693b206
has only substance units: false
name: PANK1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:53354
is: Q8TE04
initial amount: NaN
boundary condition: true

metaR ALADGLYexR
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
name: D-alanine/glycine reversible exchange
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_351db076_00e2_4381_b746_2475ca974730
initial amount: NaN
is: Q9NVF9
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55224
type: Species
name: ETNK2

metaR r1589
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_68898be1_4c50_426e_bcfc_5e7a409e250f
name: ADH1B
is encoded by: hsa:125
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P00325

metaM ksi deg29 l
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
type: Species
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 29
boundary condition: false
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_af18d314_901c_4782_897b_b9ad259d8280
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: PRDX1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5052
boundary condition: true
is: Q06830

metaR O2tn
is described by: ECO:0000000
name: O2 nuclear transport
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaM arachd r
is: CHEBI:32395
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: arachidonate
initial concentration: 1.0
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110016#_5a87ccfb_f459_4ed4_93fd_0f254a453cdf
name: NAGA
is encoded by: hsa:4668
is: P17050
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM accoa c
type: Species
constant: false
is: CHEBI:57288
is: C00024
is: HMDB01206
boundary condition: false
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_e4f06f23_6b4a_4ba0_b9c9_656f11e1688c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4705
constant: false
name: NDUFA10
boundary condition: true
is: O95299
type: Species
initial amount: NaN
initial concentration: NaN

metaM homoval m
is: CHEBI:545959
is: HMDB00118
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
has only substance units: false
constant: false
name: Homovanillate

metaM val L e
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
is: HMDB00883
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: L-valine
is: CHEBI:16414

metaR ACACT1r
kinetic law: MODEL1310110016#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
modifier: MODEL1310110016#
name: acetyl-CoA C-acetyltransferase
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM crn x
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00062
has only substance units: false
is: C00318
is: CHEBI:16347
initial amount: NaN
name: L-Carnitine
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR r0633
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
fast: false
reversible: true
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR ALOX52
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.34
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110016#
name: Arachidonate 5-lipoxygenase

metaM amet m
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial amount: NaN
name: S-Adenosyl-L-methionine
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01185
is: CHEBI:15414
is: C00019

http://identifiers.org/biomodels.db/MODEL1310110016#_501cd2fa_c92d_4fd0_afdd_b245f296df82
has part: Q9UPY5
name: SLC7A11:SLC3A2
has only substance units: false
is encoded by: hsa:23657
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a375ca57_12ce_4642_b07d_2dfeaca36598
constant: false
has part: P43034
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
is encoded by: hsa:5048
type: Species
is: SBO:0000297

metaR r1615
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2426C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
type: Reaction
name: RE2426
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM h2o x
constant: false
is: HMDB02111
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: CHEBI:15377
has only substance units: false
is: C00001
type: Species
initial amount: NaN
name: H2O

metaR r1088
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Active transport
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6754abdf_3be9_4017_8875_6c2684f0ebc8
boundary condition: true
constant: false
is encoded by: hsa:37
name: ACADVL
initial amount: NaN
has only substance units: false
type: Species
is: P49748
is: SBO:0000252
initial concentration: NaN

metaR O2tm
reactant: MODEL1310110016#
fast: false
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: O2 transport (diffusion)
type: Reaction

metaM coa x
is: SBO:0000247
name: Coenzyme A
type: Species
is: HMDB01423
has only substance units: false
constant: false
is: C00010
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false

metaM gltcho e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1200026H2200045NO1100007S CHARGE: 0
name: beta glucan-taurocholic acid complex
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790

metaR S3TASE3ly
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_7c57bb3b_8ec3_40f1_bb37_f0ec95c89591
is encoded by: hsa:4258
boundary condition: true
initial concentration: NaN
is: D6RBB5
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: MGST2
constant: false

metaM estradiol r
initial amount: NaN
constant: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
has only substance units: false
is: HMDB00151
initial concentration: 1.0
name: estradiol
boundary condition: false
is: CHEBI:16469
type: Species
is: SBO:0000247

metaM xylt c
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: xylitol
type: Species
is: SBO:0000247
is: CHEBI:17151

metaM itp e
has only substance units: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: ITP(3-)

metaR r1614
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaM hs deg22 l
is: CHEBI:21338
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR NDPK6n
type: Reaction
is described by: ECO:0000304
reversible: true
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01358
is: CHEBI:17898
constant: false
has only substance units: false
name: all-trans-retinal
boundary condition: false

metaR r1992
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110016#

metaR r1018
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: Transport reaction
reversible: true
product: MODEL1310110016#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_883bac1e_35da_4526_b624_1f5fa4582b94
name: PKM2
is encoded by: hsa:5315
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P14618
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r0845
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
reversible: false
type: Reaction

metaM glygly c
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB11733
name: Glycyl-glycine
is: C02037

metaR O2tp
reversible: true
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
name: O2 transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110016#

metaM oxa m
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:30623
constant: false
is: HMDB02329
name: oxalate(2-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN

metaR RE0453C
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
name: RE0453
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
reversible: true

metaM val L c
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: CHEBI:16414
type: Species
is: HMDB00883
boundary condition: false
name: L-valine

metaR XOLEST2te
product: MODEL1310110016#
reversible: true
name: cholesterol ester transporter
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
is: SBO:0000185
reactant: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_f1d480a8_4b25_434c_ab01_9a4ef23b3409
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: Q9Y2D0
initial amount: NaN
is encoded by: hsa:11238
name: CA5B

metaR TRPt
name: L-tryptophan transport
product: MODEL1310110016#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

metaR NDP7g
is described by: ECO:0000269
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
reversible: false
name: nucleoside-diphosphatase (UDP), Golgi apparatus
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction

metaM cholcoaone x
type: Species
constant: false
is: HMDB06891
has only substance units: false
is: CHEBI:58507
initial concentration: 1.0
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467

metaM leugly c
has only substance units: false
is: http://identifiers.org/pubchem.compound/97364
name: Leucylglycine
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C8H16N2O3 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaR r1617
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pi r
constant: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: C00009
is: HMDB00973
is: SBO:0000247
type: Species
boundary condition: false
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false

metaR G3PD1
modifier: MODEL1310110016#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000269
name: glycerol-3-phosphate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
product: MODEL1310110016#

metaR PVD3
name: Previtamin D3 formation
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
reversible: true

metaM gsn c
is: CHEBI:16750
name: Guanosine
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
is: SBO:0000247
is: HMDB00133

metaM xoltriol c
initial amount: NaN
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
initial concentration: 1.0
is: HMDB01457

metaR r1991
modifier: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
type: Reaction

metaM nad m
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Nicotinamide adenine dinucleotide
type: Species
constant: false
is: CHEBI:57540
is: HMDB00902
is: C00003
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0

metaR r1019
fast: false
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110016#

metaM paf hs e
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine

metaM fucfucgalacglcgalgluside hs c
has only substance units: false
boundary condition: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: HMDB00174
name: Leb glycolipid
constant: false
is: CHEBI:18287
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_628c1bcd_7ad9_4b2c_89bd_6033e89a8f31
has only substance units: false
is: SBO:0000252
is: Q86XP1
constant: false
type: Species
boundary condition: true
name: DGKH
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:160851

metaM CE2424 m
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: SBO:0000247
is: CHEBI:28387
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB11123
type: Species

metaR PGS
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.99.1
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
name: Prostaglandin G/H synthase
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269

metaR PIPLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: phosphatidylinositol phospholipase C, nucleus
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false

metaR r0630
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.1
reversible: true

metaR r1616
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM xylt e
type: Species
is: SBO:0000247
is: CHEBI:17151
is: HMDB02917
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
initial concentration: 1.0
name: xylitol
constant: false
boundary condition: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM thp2c x
type: Species
name: 1-piperideine-6-carboxylate
is: HMDB12130
is: CHEBI:16987
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false

metaR DNDPt9m
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: false
name: dADP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110016#_5ce305d7_532f_4d8c_8c1f_4409599d8295
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PLCB1
is encoded by: hsa:23236
constant: false

metaR XOL7AH2tm
reactant: MODEL1310110016#
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#

metaR URIK1
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
modifier: MODEL1310110016#
name: uridine kinase (ATP:Uridine)
is described by: ECO:0000269
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a00eb5ec_b889_4f49_a91d_c7dc91bdf760
constant: false
initial concentration: NaN
type: Species
name: DCK
is: P27707
initial amount: NaN
is encoded by: hsa:1633
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR CDS
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110016#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
name: phosphatidate cytidylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110016#_5da02a23_c6c5_4057_8491_3e6ed7c38a9b
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NM 001929
name: _NM_001929_1_c

metaM h2o c
is: CHEBI:3303
is: C00001
name: H2O
boundary condition: false
initial amount: NaN
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaR GALSIDEtg
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
name: galactocerebroside intracellular transport
is: SBO:0000185

metaR 2OXOADPTm
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: 2-oxoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is: SBO:0000185
type: Reaction

metaR GLCAASE8ly
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110016#
fast: false
name: beta-glucuronidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110016#
reversible: false

metaR CYSt4
reactant: MODEL1310110016#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
fast: false
name: L-cysteine reversible transport via sodium symport
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reversible: false
modifier: MODEL1310110016#

metaR GLYCtm
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: glycerol transport

metaM Rtotal2 c
is: HMDB01564
constant: false
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: R total 2 position
has only substance units: false
is: CHEBI:57876

metaM dhf c
name: 7,8-Dihydrofolate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57451
has only substance units: false
constant: false
is: C00415
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: HMDB01056

metaM ksi deg25 l
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 25
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: CHEBI:16953
boundary condition: false
type: Species
is: HMDB00812

metaR RTOTAL3FATPc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR FAS100COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110016#
name: fatty acyl-CoA synthase (n-C10:0CoA)

metaM fol m
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27470
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
initial amount: NaN
is: HMDB00121
boundary condition: false
constant: false
has only substance units: false

metaM glyclt x
is: CHEBI:29805
name: glycolate
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00115

metaR r2364
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM paf hs c
is: SBO:0000247
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR GALU
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134
modifier: MODEL1310110016#
name: UTP-glucose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction
product: MODEL1310110016#
is: SBO:0000176
fast: false

metaR r0311
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
type: Reaction
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
product: MODEL1310110016#

metaM xtsn c
boundary condition: false
is: HMDB00299
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
name: xanthosine
type: Species
initial concentration: 1.0
is: CHEBI:18107
is: SBO:0000247
has only substance units: false
constant: false

metaR NDPK6m
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110016#

metaR r1622
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM frdp c
initial amount: NaN
is: HMDB00961
type: Species
is: C00448
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
initial concentration: 1.0
name: Farnesyl diphosphate
is: CHEBI:175763
is: SBO:0000247
constant: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_86099db0_2b50_432a_a9bd_9a435ef9dce9
is: SBO:0000252
name: NDUFA9
is encoded by: hsa:4704
has only substance units: false
is: Q16795
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_4eb03c1f_a45c_4abb_9fcd_dd1ac52b7c13
constant: false
is encoded by: hsa:23657
is: SBO:0000252
is: Q9UPY5
has only substance units: false
name: SLC7A11
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR CTPtn
is: SBO:0000185
fast: false
name: CTP diffusion in nucleus
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true

metaR RAI2
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
type: Reaction
name: retinal isomerase (9-cis)
product: MODEL1310110016#
is described by: ECO:0000000

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal

metaM fmn e
initial amount: NaN
name: FMN
has only substance units: false
is: C00061
boundary condition: false
constant: false
is: HMDB01520
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H19N4O9P CHARGE: -2
is: CHEBI:58210
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_d7f983ec_e52c_4eb7_b26f_493a000e9ce3
boundary condition: true
name: CROT
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54677
initial concentration: NaN
type: Species
is: E7EQF2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_1f608a07_aab0_4561_8515_0536c450c305
constant: false
is encoded by: hsa:10050
type: Species
has only substance units: false
boundary condition: true
name: SLC17A4
is: Q9Y2C5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM cholcoa c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
is: HMDB01374
has only substance units: false
boundary condition: false
is: CHEBI:57373
type: Species
initial amount: NaN

metaM C05280 m
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
is: CHEBI:28002
initial amount: NaN
name: cis,cis-3,6-Dodecadienoyl-CoA
is: SBO:0000247
boundary condition: false
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110016#_e8ef2930_e953_4bff_9be6_6ade1d709986
name: GBA
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2629
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_4c82ca8a_71f6_4c04_8c01_e8d94ef8e6da
is encoded by: hsa:3635
boundary condition: true
initial concentration: NaN
name: INPP5D
initial amount: NaN
has only substance units: false
constant: false
is: Q92835
is: SBO:0000252
type: Species

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaM dtmp c
type: Species
has only substance units: false
is: C00364
is: CHEBI:26999
initial concentration: 1.0
name: dTMP
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
is: HMDB01227

http://identifiers.org/biomodels.db/MODEL1310110016#_4787f14c_8ed7_47f9_b5ff_63900d8dfd42
is encoded by: hsa:501
is: SBO:0000252
is: E7EPT3
constant: false
initial amount: NaN
name: ALDH7A1
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r2363
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
type: Species
boundary condition: false
is: C05552
is: SBO:0000247
is: HMDB03134
has only substance units: false
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)

metaR RAI1
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
name: retinal isomerase (11-cis)
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#

metaR r1623
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_5ce80773_be96_4682_9793_4bce24427214
constant: false
is: Q969X2
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ST6GALNAC6
is encoded by: hsa:30815

metaM tsul c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16094
initial amount: NaN
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
type: Species
is: HMDB00257
boundary condition: false

metaM estradiol e
is: HMDB00151
is: CHEBI:16469
has only substance units: false
type: Species
boundary condition: false
name: estradiol
constant: false
initial amount: NaN
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: SBO:0000247
initial concentration: 1.0

metaR r0527
is: SBO:0000176
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reversible: true
type: Reaction

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:32372
is: HMDB03229
type: Species

metaM mi34p c
is: CHEBI:28858
is: HMDB06235
constant: false
is: SBO:0000247
initial amount: NaN
name: 1D-myo-Inositol 3,4-bisphosphate
has only substance units: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
initial concentration: 1.0
boundary condition: false

metaR CBR2
fast: false
modifier: MODEL1310110016#
name: Carbonyl reductase [NADPH] 1
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.189
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
is described by: ECO:0000269
kinetic law: MODEL1310110016#
type: Reaction

metaR 3SALATAi
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000304
fast: false
name: 3-sulfino-alanine transaminase (irreversible)

http://identifiers.org/biomodels.db/MODEL1310110016#_b7a763f6_0cb2_4050_a80a_7146e94e59c7
is encoded by: hsa:6647
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: P00441
name: SOD1

metaM h2o e
constant: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
initial concentration: 1.0
is: C00001
is: HMDB02111
has only substance units: false
is: CHEBI:15377
boundary condition: false
type: Species
is: SBO:0000247

metaR PEt
kinetic law: MODEL1310110016#
is: SBO:0000185
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
fast: false
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction

metaR RE0691C
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
name: RE0691
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176

metaR r1428
fast: false
is described by: ECO:0000000
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185

metaR r2366
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110016#

metaR r1580
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR ACOAO7p
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
fast: false

metaR TCHOLAte
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_527c3f64_fdbc_4e45_b88d_2737bb5f1bb1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9P212
is encoded by: hsa:51196
constant: false
name: PLCE1
initial amount: NaN
type: Species
has only substance units: false

metaM accoa r
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57288
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR UMPK2n
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
name: UMP kinase (CTP),nuclear
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r1624
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2131
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR 3HCO3 NAt
kinetic law: MODEL1310110016#
fast: false
reversible: true
type: Reaction
name: 3HCO3_NAt
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110016#

metaM CE4792 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
is: CHEBI:12947
initial amount: NaN
name: 3-oxo-cis-8-tetradecenoyl-CoA
boundary condition: false
constant: false
type: Species

metaR DM dgtp n
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgtp(n)
type: Reaction

metaR STRDNCt
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_53dc2f2a_4358_48cd_97d6_8877fbba25a4
initial concentration: NaN
type: Species
name: _AI972237_1_c
is encoded by: hsa:AI972237
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM fmn c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00061
initial concentration: 1.0
constant: false
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
name: FMN
is: SBO:0000247
is: CHEBI:58210

metaM CE0785 m
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:57795
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial concentration: 1.0
boundary condition: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247

metaR ALCD21 L
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110016#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110016#
name: alcohol dehydrogenase (L-1,2-propanediol)
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
product: MODEL1310110016#

metaR r1625
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR DNDPt29m
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
product: MODEL1310110016#
name: dCDP transport via dADP antiport
reversible: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_2dd118d0_b388_4d72_8bdf_0c1b0aa02f6e
is: Q9Y259
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1120
type: Species
name: CHKB
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR r1090
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: false
fast: false
kinetic law: MODEL1310110016#
type: Reaction
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is: SBO:0000185

metaM CE5119 m
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:12947
boundary condition: false
has only substance units: false
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

http://identifiers.org/biomodels.db/MODEL1310110016#_67385ae7_bb46_40b8_8902_a63b64c3a2c2
type: Species
initial concentration: NaN
is encoded by: hsa:55
is: P15309
has only substance units: false
boundary condition: true
name: ACPP
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1429
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Free diffusion
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM atp e
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00538
is: C00002
name: ATP(4-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57299

metaR CSNATer
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-acetyltransferase, endolasmic reticulum
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is described by: ECO:0000254
reactant: MODEL1310110016#
type: Reaction
reversible: true
is: SBO:0000176

metaR UDPACGALtl
name: udpacgal intracellular transport
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
product: MODEL1310110016#
type: Reaction

metaR GLCNACASE1ly
fast: false
reactant: MODEL1310110016#
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.50

http://identifiers.org/biomodels.db/MODEL1310110016#_3e7c82f5_9c18_4b66_a9a8_75d2d2698269
name: CYP1B1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1545
boundary condition: true
constant: false
is: Q16678
type: Species

metaR r2365
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
product: MODEL1310110016#

metaM xol7ah3 m
is: HMDB12455
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,26-triol
type: Species
is: CHEBI:28540
initial amount: NaN

metaR IDOAASE1ly
fast: false
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
product: MODEL1310110016#
name: alpha-L-iduronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_b0754660_4492_4620_977a_3464ba7e0a47
boundary condition: true
initial amount: NaN
constant: false
name: SLC4A3
is: P48751
is: SBO:0000252
is encoded by: hsa:6508
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_11327db2_c818_492e_bae8_2a58818b3269
initial concentration: NaN
is encoded by: hsa:1718
is: Q15392
constant: false
name: DHCR24
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR S3TASE2ly
reversible: true
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR SERGLNexR
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110016#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000304

metaR r2132
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_10a9419c_480d_4fa0_9a5b_8ce4c6de14b7
initial concentration: NaN
name: SLC5A8
type: Species
is encoded by: hsa:160728
constant: false
initial amount: NaN
boundary condition: true
is: Q8N695
is: SBO:0000252
has only substance units: false

metaR GPIAT
is: SBO:0000176
reactant: MODEL1310110016#
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
modifier: MODEL1310110016#
name: glucosaminylphosphatidyl inositol acetyltransferase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_974be2b2_6bcc_41b8_a6bb_4de29b526b1e
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:F23536
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _F23536_1_m

metaR r0276
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110016#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR SPC HSt
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_aca97f08_ec55_4bd6_9f85_e57898c34d6f
boundary condition: true
name: DGKH
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:160851
is: SBO:0000252
has only substance units: false
type: Species
is: A8K0I1

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ae0eef67_8e65_46cc_84b9_353a46602659
constant: false
name: SGPL1
boundary condition: true
is: O95470
is encoded by: hsa:8879
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_93ab364e_2653_4562_98f2_b58f6ca3b7c3
is: SBO:0000252
initial amount: NaN
is: A8K761
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4716
constant: false
boundary condition: true
name: NDUFB10

metaR BILDGLCURtr
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction
name: glucuronidated compound transport
is: SBO:0000185

metaM hdcea e
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
constant: false
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
initial amount: NaN
is: CHEBI:32372
type: Species
has only substance units: false
is: HMDB03229
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_d3afd9c4_e57d_4756_bdc7_fa76aa055569
has only substance units: false
is: O00746
constant: false
is encoded by: hsa:4833
initial concentration: NaN
boundary condition: true
name: NME4
initial amount: NaN
type: Species
is: SBO:0000252

metaR O2ter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
reversible: true
is: SBO:0000185

metaR r0497
reversible: true
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
product: MODEL1310110016#

metaM itp n
is: CHEBI:57614
has only substance units: false
initial concentration: 1.0
name: ITP(3-)
initial amount: NaN
is: HMDB00189
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_46c53c7b_d447_424a_b82d_1bb8e82a23c3
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:43
initial concentration: NaN
name: ACHE
initial amount: NaN
boundary condition: true

metaM 6hoxmelatn c
boundary condition: false
initial concentration: 1.0
is: C05643
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
has only substance units: false
type: Species
is: HMDB04081
constant: false
is: http://identifiers.org/pubchem.compound/7954
name: 6-Hydroxymelatonin
is: SBO:0000247

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM hs deg6 l
is: HMDB06254
constant: false
initial concentration: 1.0
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 6
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_8c959914_2c57_49ff_85e9_5f814893c1a1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q4J699
constant: false
type: Species
name: ATP2B2
initial amount: NaN
boundary condition: true
is encoded by: hsa:491

http://identifiers.org/biomodels.db/MODEL1310110016#_b1c327fa_451b_4788_8427_aa72191e0e6b
boundary condition: true
has only substance units: false
is encoded by: hsa:84693
initial amount: NaN
type: Species
is: Q96PE7
constant: false
initial concentration: NaN
is: SBO:0000252
name: MCEE

metaR r2368
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#

metaM maltpt e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
is: C02052
initial amount: NaN
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
constant: false
initial concentration: 1.0
name: maltopentaose
boundary condition: false
has only substance units: false
type: Species

metaM 4mop m
boundary condition: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00695
initial amount: NaN
is: SBO:0000247
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110016#_8a55fbd9_a6be_470e_9c3e_4f99f4abd50f
boundary condition: true
is: SBO:0000252
name: TKTL1
constant: false
initial concentration: NaN
is encoded by: hsa:8277
initial amount: NaN
is: B7Z7I0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_e0f74ea0_a2c6_43c7_a779_e345e67bfa0f
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51227
name: PIGP
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR GALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: galactocerebroside intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_83526feb_1b52_4397_a586_4715fe58236e
type: Species
initial amount: NaN
has only substance units: false
name: PLCB3
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5331
is: G5E960
is: SBO:0000252

metaM strdnc c
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06547
type: Species

metaM gly x
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
initial concentration: 1.0
is: HMDB00123
name: glycine
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15428
type: Species

metaR NACHORCTL3le
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_95daeb8a_806f_476e_befc_abf7f2c9e15e
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P30566
is encoded by: hsa:158
constant: false
initial amount: NaN
name: ADSL
is: SBO:0000252

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR PA HStn
is: SBO:0000185
name: phosphatidate transport, nuclear
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110016#

metaR ACACT10m
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency

http://identifiers.org/biomodels.db/MODEL1310110016#_6127f020_ca11_485b_b2a6_f84468722aaa
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PYCR2
constant: false
is encoded by: hsa:29920
has only substance units: false
type: Species
is: Q96C36

http://identifiers.org/biomodels.db/MODEL1310110016#_5d4c2f30_31a6_4538_b60b_d207e3aac1ec
boundary condition: true
constant: false
is encoded by: hsa:2109
is: SBO:0000252
initial amount: NaN
is: P38117
type: Species
name: ETFB
initial concentration: NaN
has only substance units: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
product: MODEL1310110016#

metaR r1581
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185

metaR P5CDm
product: MODEL1310110016#
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
modifier: MODEL1310110016#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

metaR GALASE20ly
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176

metaM tdcoa x
initial concentration: 1.0
initial amount: NaN
is: C02593
is: SBO:0000247
is: HMDB01521
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_1a17bb7a_3d8a_4465_ad05_21666ac55b66
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: Q13510
has only substance units: false
name: ASAH1
type: Species
boundary condition: true
is encoded by: hsa:427

http://identifiers.org/biomodels.db/MODEL1310110016#_de883979_2f68_49de_95b3_c07e6d41cb4d
is encoded by: hsa:80347
boundary condition: true
name: COASY
type: Species
is: Q13057
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaM Rtotal2 e
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: CHEBI:3554
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
is: SBO:0000247
boundary condition: false
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110016#_fece14f0_0fed_4b95_9f38_727be6c661b0
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: TM7SF2
is: O76062
initial concentration: NaN
type: Species
is encoded by: hsa:7108
constant: false

metaR PROSTGI2tr
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Prostaglandin I2 transport (ER)
fast: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR CYTK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
modifier: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110016#
is described by: ECO:0000269

metaR RE2659R
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2659
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is: SBO:0000176

metaR r0317
reversible: true
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6cf506d2_5aaa_425c_8056_99c7f3bdda59
type: Species
name: _AI694761_1_c
initial concentration: NaN
is encoded by: hsa:AI694761
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_10609a25_7765_4e7f_be8d_db1c640b3976
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GAD1
type: Species
boundary condition: true
is encoded by: hsa:2571
is: Q99259
constant: false
initial concentration: NaN

metaR NACASPtm
is: SBO:0000185
type: Reaction
reversible: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_d0cdd87f_33b9_47fe_b4fe_3cf1243385db
name: NDUFB6
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4712
boundary condition: true
is: O95139

metaM 2dr5p c
boundary condition: false
has only substance units: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
is: HMDB01031
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR ACITL
reversible: false
name: ATP-Citrate lyase
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8

metaR r1620
product: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110016#

metaR r1584
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_3e68ceaf_4c5a_4cbb_9fb8_9f0be66c9504
name: ND4L
is encoded by: hsa:4539
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q7GXZ4
constant: false
boundary condition: true
type: Species

metaM accoa n
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: acetyl-CoA(4-)
is: CHEBI:57288
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206

metaM bilglcur r
is: CHEBI:57767
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR NACHEX23ly
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110016#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c621f718_9dc3_4ebd_8afe_e9279ec7914d
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2026
is: P09104
name: ENO2
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0739
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:

metaR NACHEX19ly
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false

metaM strdnc e
is: http://identifiers.org/pubchem.compound/47205608
boundary condition: false
is: SBO:0000247
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
constant: false
name: stearidonic acid C18:4, n-3
is: HMDB06547
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d07856b9_22c6_4951_bb1d_f6cbb71d3e7d
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:10476
has only substance units: false
is: O75947
initial amount: NaN
is: SBO:0000252
constant: false
name: ATP5H

metaM oxa e
boundary condition: false
is: CHEBI:30623
has only substance units: false
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_bb394a0e_13eb_4160_81d5_b27f4844e598
has only substance units: false
name: PIGA
initial amount: NaN
constant: false
is: P37287
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5277
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d83dc5c7_870c_466d_9c1b_a155699e603d
name: ACOT4
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q8N9L9
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:122970

metaR LEUKTRD4t
type: Reaction
fast: false
reactant: MODEL1310110016#
name: leukotriene D4 transport
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
kinetic law: MODEL1310110016#
reversible: true

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_7ee44b2c_8781_4233_ba70_ede3552b5b4c
initial concentration: NaN
constant: false
initial amount: NaN
name: SOAT1
type: Species
is encoded by: hsa:6646
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B4DU95

http://identifiers.org/biomodels.db/MODEL1310110016#_e13935a3_700f_4d71_88bc_f012376f9af8
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA081045
initial concentration: NaN
type: Species
name: _AA081045_1_m

metaR r1621
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6477bd27_b57a_4513_8511_8ee0af5e7a5f
initial concentration: NaN
has part: P13804
constant: false
type: Species
name: ETFA:ETFB
has only substance units: false
is encoded by: hsa:2108
initial amount: NaN
is encoded by: hsa:2109
boundary condition: true
is: SBO:0000297

metaR r1010
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
name: Postulated transport reaction

metaM dtmp e
is: CHEBI:26999
name: dTMP(2-)
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01227
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaM sphmyln hs c
is: CHEBI:21338
is: SBO:0000247
initial concentration: 1.0
name: sphmyln_hs[c]
boundary condition: false
constant: false
has only substance units: false
type: Species
is: HMDB02704
initial amount: NaN
notes: FORMULA: CHARGE: 0

metaM accoa m
name: Acetyl-CoA
is: HMDB01206
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: C00024

http://identifiers.org/biomodels.db/MODEL1310110016#_62f24c35_2686_4747_8b44_7d9e5f2a9d04
initial amount: NaN
initial concentration: NaN
constant: false
name: GALNTL2
is: Q8N3T1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:117248

http://identifiers.org/biomodels.db/MODEL1310110016#_4b133ccb_05ea_42fa_995e_788d9fbfef53
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4712
has only substance units: false
initial concentration: NaN
name: NDUFB6
is: SBO:0000252
is: Q5VYT2
type: Species

metaR r1583
reactant: MODEL1310110016#
reversible: true
fast: false
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110016#

metaR r0627
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false

metaM ksi deg5 l
initial concentration: 1.0
boundary condition: false
is: HMDB00143
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 5
is: CHEBI:12936
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
type: Reaction

metaR r2369
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
reactant: MODEL1310110016#

metaR DRPA
reactant: MODEL1310110016#
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:

metaM h2o l
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:15377
constant: false
boundary condition: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
has only substance units: false
initial amount: NaN

metaR r0340
fast: false
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110016#
type: Reaction

metaR EX gq1balpha hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1balpha (homo sapiens) exchange
type: Reaction

metaR PSt3
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: phosphatidylserine transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110016#
fast: false

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_65c18a55_906e_438a_850d_27101ffeb03c
name: G6PC2
is encoded by: hsa:57818
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: E9PAX2

metaR MI145PP
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110016#
reversible: false
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.86

http://identifiers.org/biomodels.db/MODEL1310110016#_d36b1336_745f_484a_a00f_3733bed2e8ef
is: Q99884
is encoded by: hsa:6534
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC6A7

metaM cholp c
has only substance units: false
is: CHEBI:295975
constant: false
name: choline phosphate(1-)
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
boundary condition: false

metaM accoa x
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
constant: false
initial amount: NaN
name: Acetyl-CoA
is: HMDB01206
has only substance units: false
is: CHEBI:57288
is: C00024
boundary condition: false

metaR HISCAT1
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR RE1516M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1516
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#

metaM ksi deg38 l
has only substance units: false
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 38
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_966d2ae4_17c7_4302_a128_d460480cef00
initial concentration: NaN
type: Species
is: P51688
constant: false
is encoded by: hsa:6448
initial amount: NaN
name: SGSH
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_bac1febe_32af_4057_b0f5_64eaa2319e6e
constant: false
has only substance units: false
type: Species
name: LGALS13
is: SBO:0000252
is: Q9UHV8
is encoded by: hsa:29124
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d46e3ceb_c00d_4a79_961d_9dea8c3637f3
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:386757
initial concentration: NaN
name: SLC6A10P

metaM ura c
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: Uracil
boundary condition: false
is: HMDB00300
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial amount: NaN
is: C00106
is: CHEBI:17568

metaM ser D c
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16523
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
name: D-serine
has only substance units: false
boundary condition: false
is: HMDB03406

metaM nad c
is: C00003
is: HMDB00902
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
type: Species
is: CHEBI:57540
constant: false

metaR PPA
reactant: MODEL1310110016#
is described by: ECO:0000269
name: inorganic diphosphatase
reversible: false
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_1b41eb3d_6234_423f_8942_fa5a27811023
initial concentration: NaN
constant: false
is encoded by: hsa:230
is: P09972
is: SBO:0000252
initial amount: NaN
name: ALDOC
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_00f23123_ad99_4027_b262_25141ac73802
is encoded by: hsa:3992
name: FADS1
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O60427
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_06508d3b_78e8_47cb_a12c_c7275670f70b
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:160287
is: Q6ZMR3
type: Species
constant: false
initial concentration: NaN
name: LDHAL6A

http://identifiers.org/biomodels.db/MODEL1310110016#_c33ee72a_8939_4093_8041_d1235e195768
is encoded by: hsa:5198
initial concentration: NaN
name: PFAS
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q6P4B4
is: SBO:0000252
type: Species

metaM C05965 e
initial concentration: 1.0
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
has only substance units: false
type: Species
is: HMDB04243
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57444
boundary condition: false

metaM crn c
constant: false
is: HMDB00062
has only substance units: false
name: L-Carnitine
type: Species
is: SBO:0000247
is: C00318
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false

metaM h2o m
type: Species
initial concentration: 1.0
boundary condition: false
name: H2O
initial amount: NaN
constant: false
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: SBO:0000247
has only substance units: false
is: HMDB02111

metaR ENO
name: enolase
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110016#
fast: false
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.11
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110016#_53c84984_2b1d_461c_9bfe_eb55a8307b6a
name: PANK2
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
constant: false
is: Q9BZ23
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_03c92696_549b_47d1_b73d_7de88a716b6f
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _H77542_1_c
is encoded by: hsa:H77542
has only substance units: false

metaM fol e
name: Folate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
type: Species

metaR EX doco13ac
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_63d719b7_c28d_4348_b12b_977814229f69
initial amount: NaN
boundary condition: true
constant: false
name: AICDA
has only substance units: false
is: Q546Y9
type: Species
is: SBO:0000252
is encoded by: hsa:57379
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_0cb8d140_1707_4728_a80a_6eff52d8321c
is encoded by: hsa:2618
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: Q59HH3
name: GART
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_91c86083_226b_4a74_a078_4eb35984673a
boundary condition: true
is encoded by: hsa:6391
name: SDHC
is: Q99643
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_927f7e6d_e791_44dd_94ad_c370251389a7
is encoded by: hsa:81490
constant: false
is: Q9BVG9
name: PTDSS2
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM paps g
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134
is: CHEBI:58339
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_023952d5_4744_4e02_bbd9_96f3dcb405ba
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:728226
is: SBO:0000252
has only substance units: false
name: _728226_1_m
type: Species
boundary condition: true

metaR PLA2 2e
name: phospholipase A2
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
reversible: false
modifier: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.1.4
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false

metaR r0960
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_00b91061_12f6_43f4_b4ad_d6091c1ea7e1
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: Q9Y5P6
is encoded by: hsa:29925
boundary condition: true
name: GMPPB

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57977
name: bilirubin(2-)
initial concentration: 1.0
is: HMDB00054

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 20-hydroxy-arachidonate
is: CHEBI:34306
type: Species

metaM ahcys c
name: S-Adenosyl-L-homocysteine
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: SBO:0000247
is: C00021

metaR S6TASE18ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
type: Reaction

metaR r2516
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reversible: true
product: MODEL1310110016#
fast: false

metaR RE2999M
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: RE2999
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaM oxa c
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02329
constant: false
is: CHEBI:30623
name: oxalate(2-)
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

http://identifiers.org/biomodels.db/MODEL1310110016#_4c5abcd5_8502_47a5_8865_62513e5e48e7
type: Species
is: Q8TCD5
initial amount: NaN
is encoded by: hsa:30833
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NT5C

http://identifiers.org/biomodels.db/MODEL1310110016#_c2afd705_89aa_47aa_8931_968f3223a63b
initial amount: NaN
name: SLC7A8:SLC3A2
has part: Q9UHI5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23428
boundary condition: true
is: SBO:0000297
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_19a300ed_6219_4cf8_af17_272a9dddc314
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: MLYCD
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23417
type: Species
is: O95822

metaR r2139
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110016#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1cb35a8d_fb81_474f_8ffc_bb964a0e413e
constant: false
name: SLC38A4
is encoded by: hsa:55089
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q969I6

metaM h2o n
is: HMDB02111
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
name: water
initial amount: NaN
constant: false
type: Species
is: CHEBI:15377

metaM CE2418 m
boundary condition: false
is: HMDB11123
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28387
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418

metaM ksi deg20 l
constant: false
type: Species
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 20
has only substance units: false
boundary condition: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0

metaR r0735
reactant: MODEL1310110016#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176

metaR PYDAMK
kinetic law: MODEL1310110016#
name: pyridoxamine kinase
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.35
is described by: ECO:0000269
product: MODEL1310110016#
reversible: false

metaR VALTA
is described by: ECO:0000269
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
modifier: MODEL1310110016#
name: valine transaminase
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_c9fb3bf9_9d4f_4aa3_a955_5b292be2a2bc
boundary condition: true
has only substance units: false
is encoded by: hsa:50484
type: Species
is: Q7LG56
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: RRM2B

metaM atp n
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00538
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57299
initial amount: NaN

metaR r1777
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
reversible: false
type: Reaction
fast: false

metaR BTNPL
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: holocarboxylase synthestase (biotin protein ligase)
fast: false
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c57c48a6_8917_4142_bdbd_cd0901a4fa54
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1606
boundary condition: true
is: P23743
name: DGKA
has only substance units: false
type: Species
constant: false

metaR PGSr
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.1
fast: false
reactant: MODEL1310110016#
name: Prostaglandin G/H synthase
modifier: MODEL1310110016#
reversible: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_41d83593_9324_4b97_be33_c09f8d59c97e
name: GLUL
constant: false
is: P15104
type: Species
is encoded by: hsa:2752
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_af72fa60_c0a6_4dd2_954a_8d248bef8959
name: GCK
is: SBO:0000252
is encoded by: hsa:2645
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM aicar c
boundary condition: false
is: CHEBI:58475
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: C04677
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0
has only substance units: false

metaM ura e
constant: false
name: uracil
is: HMDB00300
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
type: Species

metaR RE0569E
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0569
type: Reaction
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#

metaR S2TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110016#
is: SBO:0000176
reversible: false
name: iduronate-2-sulfatase, lysosomal
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000

metaM CE0713 m
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 3-oxolinoleoyl-CoA
is: CHEBI:30623
constant: false
has only substance units: false
is: HMDB02329
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

http://identifiers.org/biomodels.db/MODEL1310110016#_6fc0742a_134e_43ba_b41e_23101dbdf0d0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: PANK1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:53354

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_724b8d84_f3fc_4596_9698_9317c421c86e
is encoded by: hsa:AA676725
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: _AA676725_1_c
type: Species

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is described by: ECO:0000000
name: RE2079
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_9fd17b12_5719_4c19_9287_35bdf14ab748
boundary condition: true
constant: false
has only substance units: false
type: Species
name: DPYSL2
is encoded by: hsa:1808
is: SBO:0000252
initial concentration: NaN
is: B4DR31
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ec28b3a0_d7ab_4357_a9b0_66f19904c743
constant: false
boundary condition: true
is encoded by: hsa:5743
initial amount: NaN
type: Species
name: PTGS2
is: SBO:0000252
initial concentration: NaN
is: P35354
has only substance units: false

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM glgchlo e
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
initial concentration: 1.0
constant: false
name: beta glucan-glycocholate complex

metaR CMPSAS
name: CMP sialic acid synthase
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110016#_24fad13e_4b5f_449c_ba58_5ef6646f7da1
constant: false
boundary condition: true
name: NDUFAB1
is: SBO:0000252
is encoded by: hsa:4706
initial concentration: NaN
has only substance units: false
is: O14561
type: Species
initial amount: NaN

metaR r2514
product: MODEL1310110016#
fast: false
is: SBO:0000185
name: Utilized transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000

metaR FAOXC121C10x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM atp m
initial concentration: 1.0
initial amount: NaN
name: ATP(4-)
has only substance units: false
boundary condition: false
is: CHEBI:57299
constant: false
is: HMDB00538
is: C00002
type: Species
is: SBO:0000247

metaM thr L c
is: HMDB00167
type: Species
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: L-threonine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_a13d1c13_0a7c_4d9b_9133_3c394e79da33
boundary condition: true
has only substance units: false
constant: false
name: GBA
initial amount: NaN
type: Species
is encoded by: hsa:2629
initial concentration: NaN
is: B7Z6S9
is: SBO:0000252

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_4c5d8e18_d08e_4152_b4b0_4dd99c26d04d
is: O00341
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC1A7
initial amount: NaN
is encoded by: hsa:6512
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_fdbd4c21_e186_4fd3_a34e_6adf302340b9
initial amount: NaN
is: O95139
initial concentration: NaN
is encoded by: hsa:4712
type: Species
has only substance units: false
is: SBO:0000252
name: NDUFB6
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a53ec077_0c58_4298_8568_cfb9770d1f4a
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P33261
constant: false
has only substance units: false
is encoded by: hsa:1557
initial concentration: NaN
name: CYP2C19

metaR MALSO4tm
name: Malate:sulfate antiport, mitochondrial
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is described by: ECO:0000269
type: Reaction

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
is: HMDB00054
type: Species
boundary condition: false
initial amount: NaN
name: bilirubin(2-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57977
constant: false

metaR RTOTAL2FATPc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_8ba535b9_0732_4973_a7ab_1da02e2e96ed
initial concentration: NaN
constant: false
name: PRDX1
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5052
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_cc7b07ff_7fa3_469e_8245_acbb80595fa9
is encoded by: hsa:8034
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: P16260
name: SLC25A16

http://identifiers.org/biomodels.db/MODEL1310110016#_95ea60e8_b4b6_4712_8095_bab31c3ae6e0
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5049
name: PAFAH1B2
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: A8DPS7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_72f62b51_64f9_41fe_b5ad_7bd5783da961
is: Q6IRT1
is: SBO:0000252
type: Species
name: ADH5
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:128
constant: false

metaR r2360
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaM arachd c
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
constant: false
is: CHEBI:32395
name: arachidonate
is: SBO:0000247
type: Species
is: HMDB01043
has only substance units: false
initial amount: NaN

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction

metaM dudp c
is: C01346
name: dUDP
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
constant: false
is: CHEBI:60471
is: HMDB01000
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5e65d742_9cef_48de_981c_9f71b287253a
is: SBO:0000252
is encoded by: hsa:AA502753
name: _AA502753_1_m
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_17e7746e_0f57_42be_89cd_8968f2961426
is: SBO:0000252
type: Species
is: Q16348
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC15A2
is encoded by: hsa:6565
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_5dec2e6a_7c2a_4c9b_ae27_ad174bd3da09
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: SKIV2L2
boundary condition: true
is: Q3MHC9
is encoded by: hsa:23517

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_eced877d_856a_49f6_bb5f_c4810c325a5b
is: P09972
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:230
name: ALDOC
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_3614a337_84e6_4a64_9ec2_c3448e70c1e0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P18859
name: ATP5J
is encoded by: hsa:522
is: SBO:0000252

metaR RE1521M
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0733
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM h2o g
type: Species
is: CHEBI:15377
constant: false
initial amount: NaN
name: water
is: SBO:0000247
boundary condition: false
is: HMDB02111
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false

metaR PA HStg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
name: phosphatidate scramblase
type: Reaction

metaR r2519
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110016#_d5c7ed89_8e02_41e6_8ddb_75c08d8d2084
name: SLC27A2
is encoded by: hsa:11001
is: O14975
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_8d3b646b_bf73_488c_9c77_1743b05c7a86
name: PAFAH2
initial amount: NaN
initial concentration: NaN
constant: false
is: Q99487
is: SBO:0000252
is encoded by: hsa:5051
type: Species
boundary condition: true
has only substance units: false

metaM 4ppan c
is: CHEBI:10986
boundary condition: false
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
is: HMDB01016
name: D-4'-Phosphopantothenate
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C03492
constant: false

metaR ALOX5
fast: false
reactant: MODEL1310110016#
name: Arachidonate 5-lipoxygenase
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
reversible: false

metaR DOLPMT3 Uer
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
kinetic law: MODEL1310110016#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_2afcd3ec_2bca_42ba_a37b_45067f82d71d
name: ND4
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P03905
is encoded by: hsa:4538
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM thr L e
initial concentration: 1.0
is: HMDB00167
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: L-threonine
boundary condition: false
is: CHEBI:16857

metaM acgam1p c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:7125
is: HMDB01367
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
name: N-Acetyl-D-glucosamine 1-phosphate
type: Species
constant: false
initial concentration: 1.0

metaM mn l
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06535
name: beta-1,4-mannose-N-acetylglucosamine
constant: false
has only substance units: false

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR MI145PK
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127

http://identifiers.org/biomodels.db/MODEL1310110016#_2e2e67c0_e980_4d94_ab76_2eac1d752099
has only substance units: false
constant: false
is encoded by: hsa:6580
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: O15245
name: SLC22A1

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_c795985c_2254_4ac2_9a58_dac6cf67abf6
boundary condition: true
is: Q6P1K9
type: Species
initial amount: NaN
has only substance units: false
name: PANK2
is encoded by: hsa:80025
constant: false
is: SBO:0000252
initial concentration: NaN

metaM paps c
is: HMDB01134
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
is: CHEBI:58339
constant: false
initial concentration: 1.0
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
boundary condition: false
has only substance units: false

metaR NACDe
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_8e302b3a_58c0_4f72_8a7b_8d542167beee
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5050
is: Q15102
name: PAFAH1B3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_1e4d55c2_0bc4_47ed_8155_fab61e7ddb3e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q86VV3
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:953
name: ENTPD1

metaR GLXO1
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
name: glyoxylate oxidase
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
kinetic law: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_b526697f_b798_45bc_98d9_c2a879712301
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q53H96
constant: false
initial concentration: NaN
is encoded by: hsa:65263
initial amount: NaN
name: PYCRL
type: Species

metaR NBAHH ir
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
is described by: ECO:0000134
product: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.13.20
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
constant: false
initial amount: NaN
has only substance units: false
is: C00134
name: Putrescine
is: CHEBI:326268
initial concentration: 1.0
is: HMDB01414
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_27997a76_fbbe_48af_a226_d15b211b2ce0
initial amount: NaN
is encoded by: hsa:4700
type: Species
initial concentration: NaN
name: NDUFA6
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P56556
constant: false

metaM tdcoa m
initial concentration: 1.0
is: CHEBI:57385
is: HMDB01521
boundary condition: false
has only substance units: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
constant: false
is: C02593
initial amount: NaN

metaM arachd e
constant: false
boundary condition: false
is: CHEBI:32395
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
type: Species
is: HMDB01043
name: arachidonate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_3773a907_c4fc_4a47_9a80_54270fb839d1
constant: false
initial concentration: NaN
name: BDH1
is encoded by: hsa:622
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_fc72401f_4933_48ec_b812_d361cf363872
has only substance units: false
constant: false
initial concentration: NaN
name: XDH
is: SBO:0000252
type: Species
is encoded by: hsa:7498
initial amount: NaN
boundary condition: true
is: P47989

metaR r2362
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_9a70599e_ce68_4dd3_a8cc_b8a05aae06fa
is encoded by: hsa:204
is: P54819
boundary condition: true
initial amount: NaN
name: AK2
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM frdp r
boundary condition: false
has only substance units: false
is: CHEBI:175763
type: Species
is: C00448
initial amount: NaN
is: HMDB00961
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: Farnesyl diphosphate
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8d95d11b_2892_4345_aa85_b9aa87ae32fa
boundary condition: true
is: Q8N1Q1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:377677
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: CA13

metaR PIACGT
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is version of: http://identifiers.org/ec-code/2.4.1.83
modifier: MODEL1310110016#
name: phosphatidylinositol N-acetylglucosaminyltransferase
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.1.198

metaM gly m
is: SBO:0000247
constant: false
is: C00037
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
is: CHEBI:15428
is: HMDB00123

metaR 6HTSTSTERONEtr
name: hydroxylated testosterone transport
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, inactivated testosterone transport to get out of cell NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true

metaR r2517
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
reversible: true
product: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_049a3ade_2f47_4e1b_8c4e_f3b5a1955639
is encoded by: hsa:57282
initial concentration: NaN
name: SLC4A10
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
is: B7Z1R0

http://identifiers.org/biomodels.db/MODEL1310110016#_a68dc82b_2d5a_4d4b_b6c3_1e0a88a5d94c
has part: A3KLL5
is encoded by: hsa:481
is: SBO:0000297
boundary condition: true
initial amount: NaN
has part: B7Z2T0
constant: false
has only substance units: false
is encoded by: hsa:478
type: Species
name: ATP1A3:ATP1B1
initial concentration: NaN

metaR r0731
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR NH4t3r
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
name: ammonia transport via proton antiport
is: SBO:0000185
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaM lald L c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: CHEBI:18041
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB03052
name: (S)-lactaldehyde
boundary condition: false

metaM estradiol c
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: estradiol
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110016#_69c98c98_16af_4ef7_b657_a627947ceefd
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC4A5
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:57835

metaR r2361
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185

metaR r0345
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#

metaR H3ETer
reversible: false
is described by: ECO:0000304
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD

metaR VLCSp
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110016#

metaR r0310
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
kinetic law: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#

metaM crn e
initial concentration: 1.0
type: Species
boundary condition: false
is: C00318
has only substance units: false
is: SBO:0000247
is: CHEBI:16347
name: L-Carnitine
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: HMDB00062

metaR CREATt4 2 r
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110016#
type: Reaction
name: Creatine transport (sodium symport) (2:1)
reversible: true
modifier: MODEL1310110016#

metaM dtmp m
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dTMP
boundary condition: false
initial concentration: 1.0
is: CHEBI:26999
type: Species
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
is: HMDB01227

metaR r2136
kinetic law: MODEL1310110016#
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
fast: false
type: Reaction

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
is: SBO:0000247
name: 20-hydroxy-arachidonate
is: CHEBI:34306
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaR r2518
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_b8653323_fb1f_43ed_bd1a_e754d82cc8bb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26266
initial concentration: NaN
name: SLC13A4
constant: false
type: Species
boundary condition: true
is: Q9UKG4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6facdf7c_4e92_4c3e_97b3_f881e627c4e1
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: GLUD2
initial amount: NaN
has only substance units: false
is encoded by: hsa:2747
is: P49448
boundary condition: true

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR CITt4 4
modifier: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
kinetic law: MODEL1310110016#
is described by: ECO:0000006
fast: false
reversible: true
product: MODEL1310110016#
type: Reaction
name: citrate transport via sodium symport
reactant: MODEL1310110016#

metaM dd2coa x
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
is: CHEBI:57330
is: SBO:0000247
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
constant: false
boundary condition: false
has only substance units: false
name: trans-Dodec-2-enoyl-CoA

metaR r0732
reversible: false
product: MODEL1310110016#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false

metaM tsul m
initial amount: NaN
is: HMDB00257
has only substance units: false
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
type: Species
constant: false
is: CHEBI:16094
boundary condition: false
is: SBO:0000247

metaM ptrc c
is: HMDB01414
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00134
initial amount: NaN
name: Putrescine
has only substance units: false
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
is: CHEBI:28276

metaR ECOAH9m
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reactant: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000304
product: MODEL1310110016#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176

metaM atp r
constant: false
is: CHEBI:57299
type: Species
is: HMDB00538
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: ATP(4-)
is: C00002
initial amount: NaN

metaM gdpmann c
is: HMDB01163
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: GDP-alpha-D-mannose(2-)
has only substance units: false
constant: false
boundary condition: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM cholcoads x
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
constant: false
initial amount: NaN
is: CHEBI:27505
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
type: Species
is: HMDB06889

metaR ICDHy
name: isocitrate dehydrogenase (NADP)
fast: false
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
type: Reaction
reactant: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110016#

metaR PROSTGI2t
is: SBO:0000185
product: MODEL1310110016#
type: Reaction
fast: false
name: Prostaglandin I2 transport
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaR r0942
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
reversible: true
reactant: MODEL1310110016#
fast: false

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
is: HMDB03073
name: gamma-linolenate
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR HSPASEly
kinetic law: MODEL1310110016#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110016#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110016#

metaR MCPST
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.2
name: 3-mercaptopyruvate sulfurtransferase
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
reactant: MODEL1310110016#
reversible: false
fast: false
modifier: MODEL1310110016#

metaM occoa x
boundary condition: false
is: CHEBI:57386
is: C01944
is: HMDB01070
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_fbdf32fd_5f42_48e2_af45_38a34ce59c1c
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: P48067
boundary condition: true
name: SLC6A9
initial concentration: NaN
is encoded by: hsa:6536

metaR H2Otg
product: MODEL1310110016#
fast: false
name: H2O transport, Golgi apparatus
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#

metaR RE0452M
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: RE0452
fast: false
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_7fc33fc5_701f_4b99_9afa_2d29797ce5c1
constant: false
is encoded by: hsa:23464
boundary condition: true
has only substance units: false
is: E2QC23
is: SBO:0000252
name: GCAT
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_c833d58d_c669_4b6a_aea0_32dd60149e5d
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: RDH16
is encoded by: hsa:8608
initial concentration: NaN
is: O75452
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_9017ffd9_4567_43c7_bb8a_a26b66a65265
is encoded by: hsa:4720
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: NDUFS2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B7Z792

metaM leuktrB4 e
is: SBO:0000247
is: CHEBI:57461
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
boundary condition: false
initial concentration: 1.0
is: HMDB01085
constant: false

metaM CE2434 m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: CHEBI:57795
has only substance units: false
constant: false
boundary condition: false

metaR r0941
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Free diffusion
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
product: MODEL1310110016#
is: SBO:0000185
type: Reaction

metaM ksii core2 deg4 l
is: HMDB00812
initial amount: NaN
is: CHEBI:16953
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: keratan sulfate II (core 2-linked), degradation product 4
boundary condition: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1

metaM HC02202 c
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57398
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

http://identifiers.org/biomodels.db/MODEL1310110016#_88ed774e_cf5e_4c90_a0f7_e36ca3b30ad5
boundary condition: true
constant: false
is encoded by: hsa:314
type: Species
is: SBO:0000252
initial concentration: NaN
name: AOC2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_087cd66f_6b35_456a_830c_de6ce2bd6df9
boundary condition: true
initial concentration: NaN
type: Species
is: P53794
constant: false
name: SLC5A3
has only substance units: false
initial amount: NaN
is encoded by: hsa:6526
is: SBO:0000252

metaM gq1balpha hs c
initial concentration: 1.0
is: C00249
type: Species
is: CHEBI:7896
is: HMDB00220
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
name: GQ1balpha

metaR r1914
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110016#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_875109f7_5c05_4fa5_9f67_89f40945d1ac
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: Q9HCC0
is encoded by: hsa:64087
name: MCCC2
initial concentration: NaN

metaM gluside hs r
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
name: D-glucosyl-N-acylsphingosine
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_9d4f6a07_3288_4d12_a2b6_016e031f5109
has only substance units: false
initial concentration: NaN
name: GGT2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:728441
initial amount: NaN
constant: false

metaR ALDD2x
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_cd8cf9be_0d9e_40c0_8ce4_2eb5662b760f
name: GLRX2
constant: false
type: Species
is: SBO:0000252
is: Q9NS18
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51022
initial amount: NaN

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
is: HMDB00073
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:59905
type: Species
name: dopaminium(1+)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_abd83b3a_a269_4f10_b9e6_6af03d5bc8b9
has only substance units: false
is: O95168
constant: false
is encoded by: hsa:4710
is: SBO:0000252
initial concentration: NaN
name: NDUFB4
type: Species
boundary condition: true
initial amount: NaN

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#

metaM HC00591 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8b079c3d_8f77_4b7a_8d35_03f0d1dc1a68
has only substance units: false
is: E9KL48
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: GLUD1
is encoded by: hsa:2746
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_589c6cd0_0180_4c5d_8bab_ef0eb0ceebc0
is: Q92911
is: SBO:0000252
constant: false
name: SLC5A5
is encoded by: hsa:6528
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaM meoh c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17790
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: methanol
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875

http://identifiers.org/biomodels.db/MODEL1310110016#_925d35c1_201a_4f2a_be50_cf1ccb98b25e
initial concentration: NaN
is: Q8N3E9
has only substance units: false
is encoded by: hsa:113026
boundary condition: true
constant: false
name: PLCD3
initial amount: NaN
is: SBO:0000252
type: Species

metaM gd1a hs g
boundary condition: false
has only substance units: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
is: CHEBI:58397

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR RE1807C
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
name: RE1807
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false

metaM L2aadp m
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00510
initial amount: NaN
name: L-2-aminoadipate(1-)
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_28fcf658_d4dd_4236_a25c_909408b2d856
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI934540
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AI934540_1_c
constant: false

metaR DRIBt
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: true
name: deoxyribose transport via diffusion
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f0555c52_6e77_4122_bcd0_56b0d51fff59
name: SLC7A8:SLC3A2
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:23428
has part: Q86U05
initial amount: NaN
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110016#_991bd58b_9101_4a7b_8e44_a48075f60daf
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P23677
has only substance units: false
name: ITPKA
type: Species
constant: false
is encoded by: hsa:3706
is: SBO:0000252

metaR r0730
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110016#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
product: MODEL1310110016#

metaM pan4p m
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:47942
boundary condition: false
initial concentration: 1.0
is: HMDB01416
constant: false
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

http://identifiers.org/biomodels.db/MODEL1310110016#_0cad0e04_e37f_452a_a4d0_a0aad718c6d7
is: Q99624
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:10991
initial amount: NaN
name: SLC38A3

metaM crm hs e
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
is: CHEBI:52639
initial amount: NaN
boundary condition: false
name: N-acylsphingosine
has only substance units: false

metaM glyald m
is: CHEBI:17378
has only substance units: false
is: HMDB01051
boundary condition: false
name: D-glyceraldehyde
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species

metaR RE3520E
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
name: RE3520
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.11.1.9

metaM ksii core2 deg2 l
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 2
is: CHEBI:12936
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
type: Species
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247

metaM lnlncg c
name: gamma-linolenate
is: CHEBI:32391
is: HMDB03073
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

http://identifiers.org/biomodels.db/MODEL1310110016#_bf109f3d_8ee9_48ca_9c45_3a327dfed8a9
is: P13073
is encoded by: hsa:1327
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: COX4I1
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_91f8154d_89e1_4f64_847b_1aa5b17453e6
is encoded by: hsa:2544
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _2544_1_c

http://identifiers.org/biomodels.db/MODEL1310110016#_3a9c38e5_dc78_4d70_bca9_68bd64a97f6b
is encoded by: hsa:2348
name: FOLR1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_3228f868_9be8_4081_a9f0_3e494e4d1ab7
is: SBO:0000297
name: ETFA:ETFB
boundary condition: true
constant: false
is encoded by: hsa:2109
type: Species
has only substance units: false
initial concentration: NaN
has part: P38117
initial amount: NaN

metaR NTD1
modifier: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
reversible: false
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176
name: 5'-nucleotidase (dUMP)

metaR TMDPK
is described by: ECO:0000269
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
fast: false
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.6.2

metaR DTTPtn
is: SBO:0000185
name: dTTP diffusion in nucleus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true

metaM leuktrB4 c
constant: false
is: CHEBI:57461
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01085

metaR r0839
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
product: MODEL1310110016#
name: Postulated transport reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.70
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_87656fa0_d1b3_4499_b1ef_26802c4de0b9
boundary condition: true
name: CMPK1
is: SBO:0000252
is encoded by: hsa:51727
is: B2R6S5
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_721fa1d9_4f46_4026_b5ae_5c12aa52bb26
has only substance units: false
name: CYP1B1
initial amount: NaN
boundary condition: true
is encoded by: hsa:1545
is: Q16678
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR r0944
is described by: ECO:0000000
reversible: true
product: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Active transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:

metaM 5HPET c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57450
is: SBO:0000247
is: HMDB01193
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
name: 5(S)-HPETE(1-)
type: Species
boundary condition: false

metaM hexde7coa x
type: Species
name: 7-hexadecenoylcoa
is: HMDB04257
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_84e6ffd6_ff72_4366_a113_1d48caf910de
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: P43251
name: BTD
initial concentration: NaN
is encoded by: hsa:686

http://identifiers.org/biomodels.db/MODEL1310110016#_56e531e7_971e_40d0_b7ab_0c08baa1bfdc
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4846
is: A0S0A7
initial amount: NaN
name: NOS3

http://identifiers.org/biomodels.db/MODEL1310110016#_8ec01bd8_9d4f_48a1_981e_a356d2a8cd02
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: GALNT10
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55568
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_52c57882_6da7_4b01_8b8a_b0c2aea7d49f
constant: false
initial concentration: NaN
is encoded by: hsa:9167
is: Q6FGA0
name: COX7A2L
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM aacoa c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
is: HMDB01484
initial concentration: 1.0
is: CHEBI:57286
is: SBO:0000247
is: C00332
constant: false
name: Acetoacetyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110016#_df07feae_5675_4b29_be8f_0e3730e7e975
constant: false
initial amount: NaN
is encoded by: hsa:AA278423
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AA278423_1_c
initial concentration: NaN

metaR PE HSter
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: phosphatidylethanolamine scramblase
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is: SBO:0000185

metaM dopa e
is: HMDB00073
initial amount: NaN
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
is: CHEBI:59905
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: dopaminium(1+)

http://identifiers.org/biomodels.db/MODEL1310110016#_6585260a_cd54_4bcb_b213_034bd8958bee
type: Species
is encoded by: hsa:2571
constant: false
initial concentration: NaN
boundary condition: true
name: GAD1
has only substance units: false
is: Q8IVA8
is: SBO:0000252
initial amount: NaN

metaM pe hs m
type: Species
name: phosphatidylethanolamine
is: CHEBI:16038
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r0838
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110016#
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR PAFH
is: SBO:0000176
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
reactant: MODEL1310110016#
name: Platelet-activating factor acetylhydrolase
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.1.47
modifier: MODEL1310110016#
reversible: false
fast: false

metaR r0191
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.24
product: MODEL1310110016#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e496e4c2_b7ab_4c9a_a45e_6451cf99cfb7
is encoded by: hsa:4125
has only substance units: false
name: MAN2B1
is: SBO:0000252
initial amount: NaN
is: O00754
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR r1917
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
fast: false

metaR CYTD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
fast: false
product: MODEL1310110016#
name: cytidine deaminase

metaM crm hs c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
type: Species
constant: false
name: N-acylsphingosine
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM itaccoa m
is: HMDB03377
name: itaconyl-CoA(5-)
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
is: CHEBI:57381
initial amount: NaN
type: Species

metaM q10h2 c
is: http://identifiers.org/pubchem.compound/6504740
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB13111
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10

metaR RE1254C
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
name: RE1254
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_735bbb47_5727_49f3_a910_96164d0135b3
initial amount: NaN
initial concentration: NaN
is: Q99714
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3028
name: HSD17B10
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_57178d3d_2bab_47ad_a026_29222944184c
name: PIGV
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is: Q9NUD9
is encoded by: hsa:55650
boundary condition: true
initial amount: NaN
has only substance units: false

metaR FK
name: Fucokinase
reactant: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.52
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
product: MODEL1310110016#
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_387c87ab_6e0d_4c3a_9188_97aabaaba31b
name: NDUFA13
is: Q9P0J0
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110016#_b9c8c162_1678_4e17_b4e8_d8ad2ab154d2
is encoded by: hsa:4056
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
is: Q16873
initial amount: NaN
initial concentration: NaN
name: LTC4S

metaR r1147
reversible: true
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_74efd15f_0bc9_4567_933f_ebf37401618a
has only substance units: false
is: P53597
initial amount: NaN
type: Species
is encoded by: hsa:8802
boundary condition: true
name: SUCLG1
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR r1292
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
type: Reaction

metaR NTD3
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: 5'-nucleotidase (dCMP)
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110016#
type: Reaction

metaR r1918
reactant: MODEL1310110016#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: false

metaM dutp n
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
is: CHEBI:17625
initial concentration: 1.0
is: HMDB01191
initial amount: NaN
constant: false
has only substance units: false
name: dUTP
type: Species
boundary condition: false

metaR ETOHt
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: ethanol reversible transport
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD

metaR FUT34g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.65
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000269

metaR NH4tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: ammonia peroxisomal transport
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_867eed5c_ee69_49de_91bb_933b640f6c31
is encoded by: hsa:3945
type: Species
has part: P00338
has only substance units: false
name: LDHA:LDHB
initial concentration: NaN
has part: P07195
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:3939
constant: false

metaR KSItly
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
name: keratan sulfate I transport, extracellular to lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110016#
reversible: false

metaR NACHEX10ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110016#_2efb000e_c53e_4847_8efc_0a81ce951123
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2109
constant: false
boundary condition: true
has only substance units: false
name: ETFB
initial concentration: NaN

metaR FADDPle
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000134
name: FAD diphosphatase
kinetic law: MODEL1310110016#
fast: false

metaR r0193
reactant: MODEL1310110016#
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110016#

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_8a7f1149_c0a8_491a_a303_39f61cf4689f
type: Species
is encoded by: hsa:1109
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P17516
name: AKR1C4
is: SBO:0000252
boundary condition: true
constant: false

metaR INSt
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000269
name: Inosine transport (diffusion)
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR

metaR RE3005M
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005
fast: false
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true

metaM gly e
is: HMDB00123
type: Species
is: CHEBI:3339
name: Glycine
boundary condition: false
is: C00037
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_021af952_520a_49de_a1d7_8e126f2dbd26
initial concentration: NaN
is: Q02318
is encoded by: hsa:1593
initial amount: NaN
name: CYP27A1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR GGH 7DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110016#
is described by: ECO:0000000
reversible: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
type: Reaction
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176
reactant: MODEL1310110016#

metaR ETF
product: MODEL1310110016#
is: SBO:0000176
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: electron transfer flavoprotein
type: Reaction
modifier: MODEL1310110016#

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
reversible: false
product: MODEL1310110016#
is described by: ECO:0000304
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c6c52941_5f2d_413b_9670_dfb60ca9fda0
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: ACAT2
initial amount: NaN
is: Q9BWD1
has only substance units: false
is encoded by: hsa:39
is: SBO:0000252

metaR NTD4
type: Reaction
is described by: ECO:0000254
name: 5'-nucleotidase (CMP)
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5

http://identifiers.org/biomodels.db/MODEL1310110016#_737f690a_40cf_4afa_933e_708cd00eedc2
boundary condition: true
type: Species
initial concentration: NaN
is: Q9UGH3
is encoded by: hsa:9962
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC23A2

metaM dutp m
is: CHEBI:17625
initial concentration: 1.0
name: dUTP
is: SBO:0000247
is: HMDB01191
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
type: Species
constant: false

metaR r0940
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110016#
type: Reaction
name: Free diffusion
reversible: true
kinetic law: MODEL1310110016#
fast: false

metaR B3GALT41g
name: Beta-1,3-galactosyltransferase 4
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.62
type: Reaction
reversible: false
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR SERDGLYexR
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000304
fast: false
name: D-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110016#
reversible: true

metaM xol7ah2 c
initial amount: NaN
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: HMDB06893
is: CHEBI:28047
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaM hestratriol r
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB05896
name: 4,17 dihydroxy estradiol
initial concentration: 1.0

metaR ITPtn
product: MODEL1310110016#
name: ITP nuclear transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000

metaR r0196
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
reactant: MODEL1310110016#

metaR DESAT18 3
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_22d75046_b75a_4263_8669_649b921fb777
is encoded by: hsa:284273
initial amount: NaN
is: Q8N4Q0
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: ZADH2
boundary condition: true
is: SBO:0000252

metaM hs deg8 l
type: Species
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 8
initial amount: NaN
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16126

metaM em2emgacpail prot hs r
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: CHEBI:16870
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00086
type: Species

metaR NTD5
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
name: 5'-nucleotidase (dTMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110016#

metaM q10h2 e
boundary condition: false
is: HMDB13111
constant: false
initial concentration: 1.0
has only substance units: false
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaR r0113
product: MODEL1310110016#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#

metaM sphgn c
constant: false
type: Species
boundary condition: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: sphinganine(1+)
is: HMDB00269
initial concentration: 1.0

metaM Rtotal2coa c
is: CHEBI:57876
initial concentration: 1.0
name: R total 2 coenzyme A
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB01564
initial amount: NaN
has only substance units: false

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00292
initial amount: NaN
boundary condition: false
is: CHEBI:17712
is: C00385
type: Species
has only substance units: false
name: Xanthine

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_f1978d58_ad3a_4172_9d5c_b08be0ad31b1
initial amount: NaN
type: Species
is: Q9BRC7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:84812
name: PLCD4
has only substance units: false

metaR DALAt2r
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000304
is: SBO:0000185
name: D-alanine transport via proton symport
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR

metaR UDPGALtg
type: Reaction
is: SBO:0000185
name: UDP-Gal Golgi transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_da1ea35b_0cc5_4d7e_89fb_79a62dd4cf78
boundary condition: true
is: SBO:0000252
name: _AA419122_1_c
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AA419122

http://identifiers.org/biomodels.db/MODEL1310110016#_5fa2810c_3c8e_4ff8_92a4_7777d2d685b0
is encoded by: hsa:2348
constant: false
name: FOLR1
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM udpg c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
is: HMDB00286
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58367
constant: false
name: UDPglucose
type: Species
is: C00029
is: SBO:0000247

metaR NH4tn
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: ammonia nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a6ba19cb_1e03_4850_8844_963e405472f5
is: P20020
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:490
initial concentration: NaN
constant: false
type: Species
name: ATP2B1

metaM fum m
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
is: C00122
is: HMDB00134
is: CHEBI:29806

metaR THRGLYexR
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
name: L-threonine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000304
product: MODEL1310110016#

metaM frdp x
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: farnesyl pyrophosphate(3-)
is: CHEBI:175763
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR BDHm
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
modifier: MODEL1310110016#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

metaM betald c
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15710
name: betaine aldehyde
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaM strch2 e
is: CHEBI:4167
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00122
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C18H32O16 CHARGE: 0
initial concentration: 1.0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})

metaM hs deg13 l
name: heparan sulfate, degradation product 13
initial amount: NaN
is: SBO:0000247
is: HMDB06254
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

metaR THCHOLSTOICtm
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a2740957_965c_40cd_add9_9391825f737d
has part: Q8TEQ8
name: PIGF:PIGO
is encoded by: hsa:5281
initial concentration: NaN
has part: Q07326
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:84720
boundary condition: true
is: SBO:0000297

metaR r1291
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c1396322_daaf_469b_834a_6c1dfa408953
type: Species
name: COX1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4512
is: Q7GXY8
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM meoh e
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
has only substance units: false
is: CHEBI:17790
is: HMDB01875
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: methanol
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_0c3ac8bb_606b_40e6_bb3c_97cfa360bc7e
initial amount: NaN
name: ATP5J
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q6NZ59
is: SBO:0000252
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110016#_3c7ff2e9_cd09_499c_b162_36f8d287c1ef
initial concentration: NaN
constant: false
type: Species
is: Q14032
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: BAAT
boundary condition: true
is encoded by: hsa:570

metaR PIPLC
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
name: phosphatidylinositol phospholipase C
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR r1575
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM glyb c
is: SBO:0000247
initial amount: NaN
is: HMDB00043
is: CHEBI:17750
name: glycine betaine
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

http://identifiers.org/biomodels.db/MODEL1310110016#_e337f5d8_2b4e_414a_97a5_1da8f0798581
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:26330
constant: false
boundary condition: true
is: O14556
is: SBO:0000252
name: GAPDHS
has only substance units: false

metaM 3hpp m
is: HMDB00700
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:16510
boundary condition: false
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0

metaR NCKt
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_20b4e64f_cb4e_4244_ac65_c8f6f2296b8f
boundary condition: true
is: SBO:0000252
constant: false
is: O75874
initial amount: NaN
name: IDH1
is encoded by: hsa:3417
has only substance units: false
type: Species
initial concentration: NaN

metaR RE1807M
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
name: RE1807
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110016#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_9806474c_aa4d_4469_b77d_24f3979359f9
name: PLCB2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5330
initial amount: NaN
type: Species
is: SBO:0000252
is: Q59F77
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_43115495_c7e6_4958_a653_57e205e766da
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC17A1
initial concentration: NaN
constant: false
type: Species
is: Q14916
boundary condition: true
is encoded by: hsa:6568

metaR PRFGS
is version of: http://identifiers.org/ec-code/6.3.5.3
reversible: false
is described by: ECO:0000269
name: phosphoribosylformylglycinamidine synthase
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110016#

metaR ABTArm
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
modifier: MODEL1310110016#
is described by: ECO:0000269
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
fast: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR PRPPS
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
reactant: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110016#
reversible: true

metaR EX hyptaur LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hypotaurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_952574ae_567f_4f71_b208_417dfd25617d
initial amount: NaN
is encoded by: hsa:125061
type: Species
is: Q63HM1
has only substance units: false
constant: false
name: AFMID
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_ccd3466d_85f4_4e9c_a08c_eeaa29bf3181
boundary condition: true
type: Species
initial concentration: NaN
is: Q9BZV2
constant: false
has only substance units: false
is: SBO:0000252
name: SLC19A3
initial amount: NaN
is encoded by: hsa:80704

metaM glc D r
initial concentration: 1.0
constant: false
is: HMDB00122
name: D-glucose
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:4167
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR r1576
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM aacoa m
type: Species
is: SBO:0000247
name: acetoacetyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57286
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01484
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM cholcoa x
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: choloyl-CoA(4-)
is: CHEBI:57373
has only substance units: false
constant: false
boundary condition: false

metaM 3dsphgn c
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: HMDB01480
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: SBO:0000247
initial amount: NaN
is: CHEBI:58299

http://identifiers.org/biomodels.db/MODEL1310110016#_264acb92_b0b3_48f8_83a7_0d1b6b305c7a
type: Species
name: TXNRD1
has only substance units: false
is encoded by: hsa:7296
is: Q16881
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_55b71fd0_711e_4dea_a5d0_0b74546f6436
has part: P22392
initial concentration: NaN
constant: false
name: NME1:NME2
has part: P15531
is encoded by: hsa:4831
initial amount: NaN
is encoded by: hsa:4830
is: SBO:0000297
type: Species
has only substance units: false
boundary condition: true

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_de8146d0_43fe_4b7c_8f04_9c2a0d736d7d
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
constant: false
name: FOLR1
is: P15328
initial concentration: NaN
type: Species

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C05645
is: HMDB04083
is: http://identifiers.org/pubchem.compound/7956
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0483
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_2afa9b86_286f_468c_84a6_8e5e2afba151
constant: false
name: GALE
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2582
initial concentration: NaN
boundary condition: true
is: Q14376

metaR PCREATtmdiffir
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB
product: MODEL1310110016#
name: Phosphocreatine transport to/from mitochondria via diffusion
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6b3105a5_cf81_4284_96cd_f242f5779264
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AL050025
name: _AL050025_1_c
constant: false

metaM dolmanp U r
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
constant: false
has only substance units: false

metaR SO4tl
product: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Sulfate transport (lysosome)
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_288e3325_18d5_4b3d_a820_99aa30e11271
is: SBO:0000252
name: COX7B2
initial concentration: NaN
is encoded by: hsa:170712
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q8TF08

metaM apoC Lys btn c
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB00182
is: CHEBI:32551

metaM gpi sig r
boundary condition: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: SBO:0000247
is: CHEBI:58190
initial amount: NaN
is: HMDB00224
notes: FORMULA: Y CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR H2Otn
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
name: H2O transport, nuclear
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction

metaM bilirub r
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
name: bilirubin(2-)
is: CHEBI:57977
boundary condition: false
is: HMDB00054
has only substance units: false
constant: false

metaR BILGLCURtr
reversible: true
name: glucuronidated compound transport
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_3279fcd1_99dc_4d99_9b5d_d85a73203b78
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1717
initial amount: NaN
name: DHCR7
is: Q9UBM7
boundary condition: true
has only substance units: false
type: Species

metaR NODe
is: SBO:0000185
name: NODe
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110016#
type: Reaction
reversible: true

metaR r2026
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110016#

metaM lnlncg l
is: CHEBI:32391
type: Species
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
is: SBO:0000247
boundary condition: false
name: gamma-linolenate
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r1573
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r2359
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaR S6TASE20ly
fast: false
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction

metaR r0480
is: SBO:0000176
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6afcceb9_6c31_41d1_9d2b_45afe1b56e93
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:220
name: ALDH1A3
has only substance units: false
initial concentration: NaN
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110016#_9d7a9ccd_441d_49cc_a013_51eb6c2389d1
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3948
is: P07864
initial concentration: NaN
name: LDHC
initial amount: NaN

metaR H2Otm
fast: false
name: H2O transport, mitochondrial
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_61de12da_b05c_4989_b22a_319e99fc7c09
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:BE966236
boundary condition: true
constant: false
name: _BE966236_1_m
has only substance units: false
initial amount: NaN

metaM 2maacoa m
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
name: 2-methylacetoacetyl-CoA(4-)
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57335
initial amount: NaN
type: Species
is: HMDB01157
initial concentration: 1.0

metaR LYStip
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
name: L-lysine transport, peroxisomal (irreversible)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR r0541
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7

http://identifiers.org/biomodels.db/MODEL1310110016#_c47f653f_bcac_420b_b699_0d69292ae70f
is: Q5JT09
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: UCK1
boundary condition: true
is encoded by: hsa:83549

metaR r1574
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM L2aadp c
is: HMDB00510
boundary condition: false
is: CHEBI:58672
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
initial amount: NaN
constant: false

metaM fdp c
is: SBO:0000247
has only substance units: false
is: C00354
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905
boundary condition: false
is: HMDB01058
type: Species
initial concentration: 1.0
name: D-Fructose 1,6-bisphosphate
constant: false
initial amount: NaN

metaM gly c
name: Glycine
is: C00037
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
is: HMDB00123

metaR HMGCOAtm
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reversible: true
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000

metaM lac L c
is: HMDB00190
name: (S)-lactate
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16651
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN

metaR r0830
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2464e3ba_d79e_4e83_b9f9_bdc090108091
boundary condition: true
is: F8W1L5
is: SBO:0000252
name: GPD1
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2819
initial concentration: NaN

metaR LEUTAm
kinetic law: MODEL1310110016#
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
name: leucine transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_73712626_377a_41d4_9a1c_c6de730b89fb
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: P37287
boundary condition: true
initial amount: NaN
is encoded by: hsa:5277
has only substance units: false
is: SBO:0000297
is encoded by: hsa:8818
constant: false
type: Species

metaR PROSTGE1t
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
type: Reaction
is: SBO:0000185

metaM pe hs e
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110016#_e8a53653_1c1f_4fd9_8459_bf1584509047
is: P00326
initial amount: NaN
name: ADH1C
initial concentration: NaN
is encoded by: hsa:126
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaR r0946
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110016#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaM lnlncg r
is: HMDB03073
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
has only substance units: false
name: gamma-linolenate
is: SBO:0000247
boundary condition: false

metaR UDPtl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
name: udp intracellular transport
kinetic law: MODEL1310110016#
type: Reaction

metaM ksi deg14 l
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 14
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00143
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
constant: false

metaR NTD7e
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
fast: false
name: 5'-nucleotidase (AMP), extracellular
is described by: ECO:0000269
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM ksi deg27 l
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: CHEBI:12936
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: keratan sulfate I, degradation product 27

metaR RE3218C
is: SBO:0000176
reversible: true
fast: false
name: RE3218
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_4b980398_09c7_4a81_8395_5148883ea44a
constant: false
is encoded by: hsa:2348
initial concentration: NaN
boundary condition: true
name: FOLR1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_20c70c5c_02b3_4b2c_bdbe_2e8af7aa0e3d
has only substance units: false
initial concentration: NaN
name: ND2
boundary condition: true
is: Q7GXY9
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4536

http://identifiers.org/biomodels.db/MODEL1310110016#_980ca7cb_bbc3_4c6e_9b03_d4cf639cd02b
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
name: PLCZ1
is encoded by: hsa:89869
is: Q86YW0
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_3ee174a4_e98e_4936_bc4c_e991730320a3
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:594
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: P21953
name: BCKDHB

metaR r0268
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
fast: false

metaR r1579
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#

metaM crm hs l
is: SBO:0000247
name: N-acylsphingosine
has only substance units: false
boundary condition: false
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_31e709e7_c823_46bc_833f_7cb819893431
initial amount: NaN
has only substance units: false
name: PPA2
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: F8WDN9
is encoded by: hsa:27068
initial concentration: NaN

metaM thcholstoic x
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:18402
constant: false
has only substance units: false
initial concentration: 1.0

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
name: glucose transport via sodium symport
fast: false

metaR FATP3t
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#
type: Reaction
name: fatty acid electroneutral transport
fast: false
reversible: true
is: SBO:0000185

metaR r1629
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110016#

metaM HC02205 e
has only substance units: false
initial amount: NaN
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: prostaglandin-b2

metaR EX glygly LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for glycylglycine
type: Reaction

metaM occoa m
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: C01944
is: CHEBI:57386
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110016#_67e5a00d_7c77_484a_8b1f_4ad6ad37925d
is: SBO:0000252
has only substance units: false
name: _AA278423_1_m
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AA278423
initial concentration: NaN

metaR PSSA2 hs
modifier: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.8.29
type: Reaction
name: Phosphatidylserine synthase homo sapiens
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR PNP
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
fast: false
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110016#
name: purine-nucleoside phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM mi3p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
boundary condition: false
name: 1D-myo-inositol 3-phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB06814
constant: false
is: CHEBI:58401
has only substance units: false
type: Species

metaR GLCURtly
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
name: glucuronate transport into lysososme
modifier: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_5e035832_408d_4d65_8250_ddf2e052607d
is: Q99643
is encoded by: hsa:6391
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SDHC
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM urate c
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00366
type: Species
initial amount: NaN
name: Urate
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: CHEBI:17775
is: HMDB00289
boundary condition: false

metaR APOC LYS BTNP
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
name: proteolysis of apoC-Lys-btn

http://identifiers.org/biomodels.db/MODEL1310110016#_87716f8a_b9e9_4636_92c4_a7c773c496b4
initial amount: NaN
is encoded by: hsa:26290
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: Q9NY28
type: Species
boundary condition: true
name: GALNT8

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110016#

metaR r0547
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
type: Reaction
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaM gq1balpha hs g
is: CHEBI:7896
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
constant: false
boundary condition: false
is: C00249
is: HMDB00220
is: SBO:0000247
initial concentration: 1.0
name: GQ1balpha
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_07e4b154_5e31_454d_95f8_f6b8adf9e555
constant: false
type: Species
is encoded by: hsa:2629
boundary condition: true
name: GBA
initial concentration: NaN
has only substance units: false
is: B7Z6S1
initial amount: NaN
is: SBO:0000252

metaM pe hs c
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
name: phosphatidylethanolamine
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16038
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a49efb72_28c4_40da_8d2a_39d8684cd709
has only substance units: false
is encoded by: hsa:218
initial amount: NaN
initial concentration: NaN
name: ALDH3A1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: P30838

http://identifiers.org/biomodels.db/MODEL1310110016#_16416aaf_fe4e_4b4a_9e4a_5d920b1d28a8
type: Species
initial amount: NaN
boundary condition: true
name: SLC25A12
initial concentration: NaN
constant: false
is: O75746
is encoded by: hsa:8604
has only substance units: false
is: SBO:0000252

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110016#
name: D-fructose transport via sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110016#_be464fe7_42b6_4976_a6a8_3fd131a48e2b
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: G6PC
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2538
is: P35575

metaM lac L e
type: Species
is: HMDB00190
is: CHEBI:16651
constant: false
is: SBO:0000247
name: (S)-lactate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cd58558b_9ca3_4d08_bfb5_c5cfd85b598f
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: _728637_1_c
is encoded by: hsa:728637
initial concentration: NaN

metaR r1298
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
type: Reaction

metaM atp c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: ATP(4-)
is: CHEBI:30616
type: Species
is: C00002
is: SBO:0000247
boundary condition: false
is: HMDB00538

metaR r0835
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#

metaM q10h2 m
is: SBO:0000247
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10
initial concentration: 1.0
is: HMDB13111
constant: false

metaM 20ahchsterol m
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06283
constant: false
is: CHEBI:1296
name: 20-hydroxycholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species

metaM 13 cis retn r
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7847414
type: Species
boundary condition: false
is: HMDB06219
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
initial concentration: 1.0
is: SBO:0000247
name: 13-cis-retinoate
constant: false

metaR 4ABUTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false

metaM hs deg1 l
name: heparan sulfate, degradation product 1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06254
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C79H115N5O99S11 CHARGE: -12

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_9dbb5111_94a9_4d91_b853_4adaf993591c
boundary condition: true
is: O43511
is encoded by: hsa:5172
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC26A4
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cb380cb5_3435_4ff4_b012_521c92ed6401
is: Q6IBK2
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: KHK
is encoded by: hsa:3795
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_26d137fc_674d_4450_913d_fc8474d83005
initial amount: NaN
has only substance units: false
name: GALNT12
is: Q8IXK2
is encoded by: hsa:79695
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r1911
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
reversible: false
name: Y+LAT2 Utilized transport

metaR r1627
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true

metaR CYTK10n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (CMP,dGTP),nuclear
reactant: MODEL1310110016#

metaM 7dhf e
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
name: heptaglutamyl folate (DHF)
initial amount: NaN
is: SBO:0000247
is: HMDB06559
constant: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_19f6213c_b181_4f04_9ad1_82c9fc46c69e
initial concentration: NaN
is encoded by: hsa:29906
type: Species
name: ST8SIA5
boundary condition: true
is: O15466
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_0574fd74_6210_462d_a59a_420c3b8f8a99
is encoded by: hsa:18
constant: false
name: ABAT
has only substance units: false
type: Species
is: P80404
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM HC01412 m
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
type: Species
boundary condition: false
name: trans-tetradec-2-enoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1299
name: Vesicular transport
product: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_eab037b8_5faf_41f8_a2b3_7e1219cd1836
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PRPS1L1
type: Species
constant: false
is encoded by: hsa:221823
is: SBO:0000252
boundary condition: true

metaR r0834
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_585064d9_4606_47f7_9ef1_c2de8c3ba058
has only substance units: false
type: Species
is encoded by: hsa:8611
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PPAP2A
is: G3XA95
constant: false
initial concentration: NaN

metaR r1578
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM xol7ah2 m
initial concentration: 1.0
is: HMDB06893
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
has only substance units: false
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha-diol
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28047

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.9

http://identifiers.org/biomodels.db/MODEL1310110016#_f146f5e4_50bd_4a62_b3f4_19a6bb8488a5
is encoded by: hsa:482
is: P14415
name: ATP1B2
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaR LNLNCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110016#

metaR r0545
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
reversible: true

metaM urate e
is: HMDB00289
is: CHEBI:17775
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial amount: NaN
constant: false
is: SBO:0000247
is: C00366
boundary condition: false
name: Urate
type: Species
has only substance units: false

metaR r1912
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110016#
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaR H2Otp
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: H2O transport, peroxisomal
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r1626
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
is: SBO:0000185

metaM HC02202 e
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57398
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM gq1balpha hs e
has only substance units: false
is: SBO:0000247
is: C00116
name: GQ1balpha
initial concentration: 1.0
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
type: Species
is: HMDB00131
boundary condition: false
is: CHEBI:17754
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_de677204_7047_4111_aacd_82776fadeda6
name: HLCS
initial amount: NaN
is encoded by: hsa:3141
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P50747
has only substance units: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM sgalside hs g
is: SBO:0000247
is: HMDB00061
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:58343
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: sulfatide galactocerebroside

http://identifiers.org/biomodels.db/MODEL1310110016#_d0380b3e_83f5_41d5_887c_cfa3d041cfe5
initial amount: NaN
type: Species
is: P04075
initial concentration: NaN
name: ALDOA
constant: false
is encoded by: hsa:226
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM thcholstoic m
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
constant: false
is: CHEBI:18402
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bbed85b2_ed56_451e_95ab_85e2bfdef15f
initial amount: NaN
constant: false
is: Q9NRX3
type: Species
is encoded by: hsa:56901
name: NDUFA4L2
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_b567ca54_d5e9_46e5_b29b_ed39c492c7fe
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55500
is: Q9HBU6
initial concentration: NaN
name: ETNK1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_9db20001_7a32_4f25_9683_aa4cc6f7d258
has only substance units: false
is: SBO:0000252
type: Species
is: P21399
name: ACO1
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:48

metaM 7dhchsterol r
is: CHEBI:17759
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
name: cholesta-5,7-dien-3beta-ol
type: Species
is: HMDB00032
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r1636
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#

metaM btamp c
name: Biotinyl-5'-AMP
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:3110
initial concentration: 1.0
is: HMDB04220
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
is: SBO:0000247

metaM hestratriol c
is: HMDB05896
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial concentration: 1.0
boundary condition: false
name: 4,17 dihydroxy estradiol
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_eef5747c_5ae4_4f47_9b47_228b3425b9e1
type: Species
is: Q96DU7
constant: false
boundary condition: true
is encoded by: hsa:80271
name: ITPKC
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM glu5sa m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
type: Species
initial amount: NaN
has only substance units: false
name: L-Glutamate 5-semialdehyde
constant: false
is: C01165
is: HMDB02104
is: CHEBI:17232

metaM pristcoa x
is: CHEBI:51341
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
is: SBO:0000247
type: Species
name: pristanoyl coa
initial amount: NaN

metaR r0051
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
product: MODEL1310110016#
reversible: true
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

http://identifiers.org/biomodels.db/MODEL1310110016#_0a565bc2_0009_4386_bb1d_7ce365a4d838
is encoded by: hsa:1345
initial amount: NaN
is: P09669
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: COX6C
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_e4984060_cf97_4659_a853_f097fe150e39
is encoded by: hsa:8402
is: F5GY65
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC25A11
type: Species
constant: false

metaR r0265
name: ATP:D-galactose 1-phosphotransferase Galactose metabolism EC:2.7.1.6
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:8908517 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaR HMGLx
fast: false
reversible: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
name: hydroxymethylglutaryl-CoA lyase

metaM co2 e
initial amount: NaN
is: C00011
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
boundary condition: false
is: CHEBI:16526
name: CO2
is: SBO:0000247
initial concentration: 1.0
is: HMDB01967
type: Species

metaM cmp e
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: CMP(2-)
is: HMDB00095
type: Species

metaR r2354
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_b8d7f306_d91f_467b_ad42_e7f5ec68984d
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:100128062
constant: false
is: SBO:0000252
name: _100128062_1_m

http://identifiers.org/biomodels.db/MODEL1310110016#_0299e684_c935_40ea_a2f6_4984b4770ef1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI373818
type: Species
name: _AI373818_1_m
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_debe3622_ef12_4b3c_8858_d3b1916360bb
boundary condition: true
name: SLC5A11
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:115584
initial concentration: NaN
is: Q8WWX8
initial amount: NaN

metaM 2mbcoa m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
name: 2-methylbutanoyl-CoA(4-)
initial amount: NaN
boundary condition: false
is: HMDB01041
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8b4f9525_7233_4366_a7d6_e8a4fd77c53f
has only substance units: false
is: Q96G03
is encoded by: hsa:55276
boundary condition: true
constant: false
type: Species
name: PGM2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM o2s e
name: superoxide
is: CHEBI:18421
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: SBO:0000247
is: HMDB02168
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaM 3hibutcoa m
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28259
constant: false
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: HMDB01052
initial amount: NaN

metaR ACACT1x
reactant: MODEL1310110016#
is described by: ECO:0000134
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5754d63c_a120_43f2_b358_d22f206f1843
is: P17516
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1109
is: SBO:0000252
boundary condition: true
name: AKR1C4

metaR r1637
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_e58c5151_785e_406d_a882_867a7564a788
is: SBO:0000252
is encoded by: hsa:8867
name: SYNJ1
is: C9JFZ1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM ala D x
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
initial amount: NaN
type: Species
is: CHEBI:15570
boundary condition: false
has only substance units: false
is: HMDB01310
is: SBO:0000247

metaR GLYCTO1p
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
name: Glycolate oxidase, peroxisome
is described by: ECO:0000269
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR CITL
name: Citrate lyase
reactant: MODEL1310110016#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#

metaR r2353
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR RPI
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
name: ribose-5-phosphate isomerase
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false

metaR MMSAD1m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
reversible: false
fast: false
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.27
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#

metaM pail4p hs c
boundary condition: false
constant: false
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM fadh2 m
initial amount: NaN
is: HMDB01197
name: Flavin adenine dinucleotide reduced
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58307
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

http://identifiers.org/biomodels.db/MODEL1310110016#_33e23a9a_ab92_436a_8d0e_28b42c518454
is encoded by: hsa:10400
initial concentration: NaN
name: PEMT
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q9UBM1
type: Species

metaM gluside hs c
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
is: CHEBI:18368
boundary condition: false
constant: false
name: D-glucosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110016#_fddb67f1_d1e8_4e33_9a2f_97ccbc7d00ab
is: Q6FG42
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFA7
is encoded by: hsa:4701
has only substance units: false
type: Species
constant: false

metaM hestratriol e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: 4,17 dihydroxy estradiol
is: HMDB05896
initial amount: NaN

metaM 6dhf e
name: hexaglutamyl folate (DHF)
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
initial amount: NaN
constant: false

metaM HC01406 m
boundary condition: false
is: CHEBI:28264
constant: false
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
name: 3-Oxooctanoyl-CoA
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM mercppyr c
is: SBO:0000247
is: CHEBI:57678
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01368
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
name: 3-mercaptopyruvate
constant: false

metaR r2352
reactant: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110016#

metaM cmp c
constant: false
name: CMP
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
is: HMDB00095

metaM co2 c
constant: false
is: CHEBI:3313
is: C00011
initial amount: NaN
is: SBO:0000247
is: HMDB01967
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: CO2
notes: FORMULA: CO2 CHARGE: 0

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true

metaM glc D l
type: Species
initial concentration: 1.0
name: D-glucose
initial amount: NaN
is: HMDB00122
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
boundary condition: false
is: CHEBI:4167

metaR PYRt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: pyruvate mitochondrial transport via proton symport
product: MODEL1310110016#
is described by: ECO:0000000

metaR r2141
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#

metaR FRDPtr
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110016#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#

MODEL1310110016
reaction: metaR GLNS
species: metaM i e
reaction: metaR CYTK1m
reaction: metaR MTHFCm
reaction: metaR r1656
species: metaM CE4790 m
reaction: metaR DNDPt28m
species: metaM arab L c
reaction: metaR RE1530M
reaction: metaR r0720
reaction: metaR r2334
reaction: metaR EX CE2839 LPAREN e RPAREN
reaction: metaR r0149
species: metaM chol c
species: metaM 4ppcys m
reaction: metaR ABTti
species: metaM 5adtststerones c
species: metaM hmgcoa x
species: metaM ppcoa m
reaction: metaR r1292
reaction: metaR SERtN1
reaction: metaR r0074
reaction: metaR NODe
reaction: metaR NDPK3n
species: metaM lthstrl r
species: metaM ade e
species: metaM f1a g
reaction: metaR BIOCYTtn
reaction: metaR EX 10fthf6glu LPAREN e RPAREN
reaction: metaR NACASPAH
species: metaM HC01496 m
species: metaM mal L e
species: metaM Rtotal2coa c
reaction: metaR r1563
reaction: metaR r0603
reaction: metaR CERT2rt
reaction: metaR r0321
reaction: metaR EX tststerone LPAREN e RPAREN
species: metaM pe hs m
reaction: metaR r1625
reaction: metaR r1602
species: metaM pro D c
species: metaM ser D e
reaction: metaR r0483
reaction: metaR r2507
species: metaM nh4 m
species: metaM CE2417 m
reaction: metaR CYOR u10m
species: metaM HC01231 c
reaction: metaR NAGA2ly
reaction: metaR HEX7
reaction: metaR XYLtly
reaction: metaR NDPK5n
reaction: metaR EX 10fthf7glu LPAREN e RPAREN
reaction: metaR DRPA
species: metaM ala D x
species: metaM CE2434 m
species: metaM ditp n
species: metaM ptrc e
reaction: metaR r2043
reaction: metaR ACCOALm
reaction: metaR r2373
species: metaM thym e
reaction: metaR r2535
species: metaM 10fthf7glu e
reaction: metaR r0594
reaction: metaR MMSAD1m
species: metaM gm1b hs g
species: metaM trdrd m
reaction: metaR RE3421R
reaction: metaR ACGPID
species: metaM cys L c
species: metaM datp n
reaction: metaR TRPt
reaction: metaR r1895
species: metaM na1 e
reaction: metaR r0801
reaction: metaR r0838
reaction: metaR r0755
reaction: metaR MMEm

metaM pmtcoa r
is: C00154
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB01338
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7c3b8530_eeaa_4d02_a8a2_0a4177afac7f
name: GBA
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2629
has only substance units: false
constant: false
is: P04062

metaM 6thf e
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial concentration: 1.0
name: hexaglutamyl folate (THF)
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
initial amount: NaN

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaM 12ppd S c
constant: false
is: SBO:0000247
boundary condition: false
name: (S)-propane-1,2-diol
has only substance units: false
is: CHEBI:29002
initial amount: NaN
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
initial concentration: 1.0
type: Species
is: HMDB06213

http://identifiers.org/biomodels.db/MODEL1310110016#_6092220c_12ec_4ff0_b656_f9eea23f8fcb
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:115111
initial concentration: NaN
name: SLC26A7

metaR PIter
name: phosphate transport, endoplasmic reticulum
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110016#_a086a840_be27_41ad_9204_a32f7b57b4e3
is encoded by: hsa:80864
initial concentration: NaN
constant: false
is: SBO:0000252
name: EGFL8
type: Species
has only substance units: false
is: Q99944
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_958ca73b_7837_405e_bdfc_f71b06e62607
name: SLC2A3
is: SBO:0000252
is: P11169
type: Species
boundary condition: true
is encoded by: hsa:6515
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR NDPK7n
kinetic law: MODEL1310110016#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
reversible: true
reactant: MODEL1310110016#
fast: false

metaR THMPPtm
reversible: false
fast: false
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT

metaR r2142
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r1635
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR ITCOALm
is described by: ECO:0000212
is: SBO:0000176
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110016#_e1b1cefa_e9a3_485b_8731_cadad3eea1e6
type: Species
is encoded by: hsa:8639
is: Q16853
name: AOC3
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR NAIt
kinetic law: MODEL1310110016#
fast: false
type: Reaction
modifier: MODEL1310110016#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Na+ / iodide cotransport
is described by: ECO:0000269

metaR r2520
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
type: Reaction
product: MODEL1310110016#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#

metaM HC02205 c
type: Species
initial concentration: 1.0
is: CHEBI:28099
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
name: prostaglandin-b2
boundary condition: false
constant: false

metaR 10FTHFtm
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185

metaR r1846
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport

metaM glc D e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: D-glucose
constant: false
is: HMDB00122
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
has only substance units: false

metaR ACALDtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
name: acetaldehyde mitochondrial diffusion

metaR PHCDm
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000304
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
reversible: false

metaM HC02208 e
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27696
is: SBO:0000247
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
has only substance units: false

metaM sgalside hs c
is: CHEBI:16523
type: Species
is: HMDB03406
name: sulfatide galactocerebroside
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r2521
is: SBO:0000185
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110016#
fast: false
type: Reaction
product: MODEL1310110016#

metaR r0614
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
type: Reaction
is: SBO:0000176

metaM udpg r
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:58367
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
constant: false
type: Species

metaM 3ohdcoa x
boundary condition: false
is: SBO:0000247
constant: false
name: 3-oxopalmitoyl-CoA(4-)
type: Species
is: HMDB06402
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57349

metaR r2358
is described by: ECO:0000000
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport

metaR BTNPLm
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
product: MODEL1310110016#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
reactant: MODEL1310110016#

metaR r1632
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_c253f790_fea2_4897_a798_9c0e0ec03e8c
constant: false
is encoded by: hsa:1103
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CHAT
initial concentration: NaN
is: Q6LEN5
boundary condition: true

metaR GGH 5DHFe
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110016#
is: SBO:0000176
reversible: false
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (5DHF), extracellular

metaR GARFT
kinetic law: MODEL1310110016#
fast: false
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_4702492d_a18d_4484_8721_93acb39f6980
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: ALAS2
type: Species
is: Q5JZF5
initial amount: NaN
is encoded by: hsa:212

metaR G6Pter
is described by: ECO:0000269
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
reversible: true

metaR r1785
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM occoa c
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false
is: CHEBI:57386
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: C01944
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_9dd1a150_aa16_4be9_90ee_b33b56bad585
name: DLST
is encoded by: hsa:1743
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P36957
has only substance units: false
type: Species
is: SBO:0000252

metaR NICRNS
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is: SBO:0000176
product: MODEL1310110016#
name: NICRNS
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reversible: false

metaR TDCHOLAte
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
name: bile acid intracellular transport
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_e3746920_3572_4c2e_86e7_371f4286e776
is encoded by: hsa:51733
is: B3KNC1
name: UPB1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_322f561f_cab7_4d18_88a0_3ae176bce5e3
name: PNPO
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55163
type: Species
is: Q9NVS9
has only substance units: false
constant: false

metaR DCYTDn
reactant: MODEL1310110016#
name: deoxycytidine deaminase, nuclear
product: MODEL1310110016#
is: SBO:0000176
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
reversible: false
type: Reaction

metaM r1p c
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: C00442
is: CHEBI:57720
name: alpha-D-Ribose 1-phosphate
is: HMDB01489
is: SBO:0000247
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial concentration: 1.0

metaR r2357
kinetic law: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR r1571
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#

metaR r0728
reversible: true
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1814f570_d6b6_48b8_869c_fd23b4ef9501
name: PCBD1
is: SBO:0000252
initial concentration: NaN
type: Species
is: P61457
is encoded by: hsa:5092
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r1633
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SUCCTD
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_4ecfe801_8d12_447c_a078_9e405cffc216
has only substance units: false
name: LTC4S
initial concentration: NaN
type: Species
is encoded by: hsa:4056
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: CHEBI:17380
name: 3-hydroxy-L-kynurenine
type: Species
is: HMDB11631
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d20914fb_88eb_493f_829f_4cfbc161d290
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AI620219_1_c
is encoded by: hsa:AI620219
boundary condition: true
type: Species

metaR r2140
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_bcc767a0_6690_4515_8bc2_c073b5ab0133
has only substance units: false
name: PANK1
type: Species
initial concentration: NaN
is encoded by: hsa:53354
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaM glygn4 e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H31O16X CHARGE: 0
type: Species
is: HMDB00122
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:4167

metaM gluside hs g
has only substance units: false
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_f3de6174_263e_4792_a835_2d5cc0506614
is: Q8TCD5
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:30833
name: NT5C
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_41f554ad_7475_4401_87fb_61eb6807d44d
constant: false
is encoded by: hsa:122622
initial concentration: NaN
is: B3KTV4
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: ADSSL1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_7f1d4cae_09ed_4623_ab0f_d1b83226b2ce
is: SBO:0000252
is encoded by: hsa:2523
boundary condition: true
name: FUT1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q6IZA2
has only substance units: false

metaR CYTK4n
type: Reaction
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM HC02208 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:27696
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
name: prostaglandin-d1

http://identifiers.org/biomodels.db/MODEL1310110016#_4b64f0c6_3cee_40e3_9648_cdeaea442a0d
name: PDXK
is encoded by: hsa:8566
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: O00764
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_f64d6c77_3443_4a70_9615_bd9ec97327b2
is: Q14117
name: DPYS
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1807
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ec83d68d_4fa7_4221_892f_1e43ac313d12
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:29920
is: Q96C36
name: PYCR2
is: SBO:0000252
type: Species
boundary condition: true

metaR CYSO
reversible: false
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.13.11.20
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
product: MODEL1310110016#
name: cysteine oxidase
is described by: ECO:0000269

metaR THP2Ctp
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal

metaR r0616
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaR AACOAT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1e3853ba_63a9_4623_a02e_2c9799371643
is encoded by: hsa:7991
has only substance units: false
name: TUSC3
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r2356
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#
is: SBO:0000185

metaR r1570
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6013ff12_8535_4ad7_a4a1_fc68fa2ff700
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6392
has only substance units: false
is: O14521
initial concentration: NaN
constant: false
is: SBO:0000252
name: SDHD

http://identifiers.org/biomodels.db/MODEL1310110016#_535ca593_4700_4538_8193_35942664ae55
constant: false
is: SBO:0000252
is encoded by: hsa:883
initial concentration: NaN
is: Q16773
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: CCBL1

http://identifiers.org/biomodels.db/MODEL1310110016#_caf26391_9e7b_40eb_8dce_cca9e4ab2e28
constant: false
is: Q05C14
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2352
name: FOLR3
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1630
fast: false
reversible: true
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM pail hs n
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: CHEBI:57880
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110016#_a4d5501a_b963_4607_8869_e8cc49165aa1
constant: false
is encoded by: hsa:6569
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q7Z725
name: SLC34A1

http://identifiers.org/biomodels.db/MODEL1310110016#_839ba4bf_5f37_44ba_ba03_8414e602e459
name: MPST
is encoded by: hsa:4357
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: P25325
boundary condition: true

metaR r0339
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.2.22
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65

metaM pmtcoa x
is: C00154
is: CHEBI:57379
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: HMDB01338

metaM o2s c
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
boundary condition: false
is: HMDB02168
initial amount: NaN
type: Species
name: superoxide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_6ba70fb1_e18d_4121_b3fd_c2beae80df9f
has only substance units: false
type: Species
is: A3KLL5
constant: false
initial amount: NaN
is encoded by: hsa:481
boundary condition: true
initial concentration: NaN
name: ATP1B1
is: SBO:0000252

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
is: CHEBI:52639
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: N-acylsphingosine
has only substance units: false

metaR r2355
kinetic law: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_68cdf962_bac3_4be5_bdc7_120dca9436ac
has only substance units: false
is encoded by: hsa:280
is: P19961
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: AMY2B
boundary condition: true

metaR r1631
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c0e84286_cda6_47e2_bd8f_dd9ed5370905
is encoded by: hsa:84701
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q96KJ9
name: COX4I2

metaR DUDPtn
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dUDP nuclear transport
reversible: true
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR r0330
reactant: MODEL1310110016#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110016#

metaR GLCNACASE5ly
reversible: false
product: MODEL1310110016#
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#

metaM o2s n
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: superoxide
is: HMDB02168
initial amount: NaN
has only substance units: false
is: CHEBI:18421
type: Species

metaR SPMTDe
reversible: true
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
name: SPMTDe
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_663bd9ac_7ab6_4c5a_b1b6_1dde39a604dc
is: B2RAU6
is encoded by: hsa:9091
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PIGQ
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a3a8d743_b955_4ed8_b9b2_577dc02f9f60
name: ALPPL2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:251
is: SBO:0000252
is: P10696
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaM no e
type: Species
has only substance units: false
is: CHEBI:16480
constant: false
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
is: HMDB03378
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r2525
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110016#

metaR r0618
reversible: true
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
is: CHEBI:27462
type: Species
constant: false
is: SBO:0000247

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaR VD3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: Vitamin D3 formation
is: SBO:0000176
is described by: ECO:0000134
reversible: true
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f34babf5_ebbf_480a_9e13_85428b8d6ad7
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AA526438
name: _AA526438_1_m
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_3fe73356_a143_4ea5_840f_fb6268407096
initial amount: NaN
name: TXNRD1
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:7296
initial concentration: NaN

metaM fum c
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
type: Species
is: C00122
initial amount: NaN
name: Fumarate
initial concentration: 1.0
is: CHEBI:29806
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM cmp n
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00095
has only substance units: false
initial concentration: 1.0
name: CMP(2-)
is: CHEBI:60377

metaR APOCF
fast: false
is: SBO:0000176
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Apocarboxylase formation
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism

metaM maltttr e
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial concentration: 1.0
initial amount: NaN
is: HMDB01296
is: SBO:0000247
constant: false
type: Species
is: C02052
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
name: Maltotetraose

metaR ACCOALm
fast: false
product: MODEL1310110016#
name: acetate-CoA ligase (AMP-forming)
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is described by: ECO:0000304
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176

metaM dolmanp U c
name: Dolichyl phosphate D-mannose, human uterine homolog
type: Species
is: CHEBI:15809
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false

metaR r0724
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110016#
fast: false
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR PI45PLC
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

metaR r1433
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_28bbe658_e437_4cf4_9ab4_a7c713fc5357
boundary condition: true
name: CA14
constant: false
is: SBO:0000252
is encoded by: hsa:23632
initial concentration: NaN
is: A8K3J4
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d7b0bb17_23a5_4cc6_aead_692fccc12354
has only substance units: false
name: ACSS2
is encoded by: hsa:55902
initial concentration: NaN
is: Q5QPH3
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR r2526
fast: false
product: MODEL1310110016#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#

metaR RE2998M
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110016#
type: Reaction
name: RE2998
product: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM f6p c
is: C00085
name: D-Fructose 6-phosphate
is: CHEBI:57579
is: HMDB00124
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3385
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_711fcd14_8d5e_4571_b3b1_a976d54455fa
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PRDX1
is encoded by: hsa:5052

http://identifiers.org/biomodels.db/MODEL1310110016#_7ac5ec29_e09b_4abd_9951_a6aba6328183
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:55350
initial concentration: NaN
type: Species
name: VNN3
is: SBO:0000252

metaR GALASE9ly
reversible: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110016#_8f78fea5_2774_492d_a358_28f8e34d6d41
initial concentration: NaN
name: SLCO2A1
initial amount: NaN
is: Q92959
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6578

metaM o2s m
is: HMDB02168
type: Species
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: C00704
constant: false
is: CHEBI:18421
has only substance units: false
name: Superoxide anion
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_f5ff9496_fa07_433c_ad75_4d8c1d3ef5e6
initial concentration: NaN
name: SLC24A3
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9HC58
has only substance units: false
is encoded by: hsa:57419
constant: false

metaR NTD8
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
reversible: false
modifier: MODEL1310110016#
name: 5'-nucleotidase (dGMP)
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
is described by: ECO:0000269
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM dhcrm hs c
is: SBO:0000247
initial amount: NaN
is: CHEBI:31488
has only substance units: false
name: dihydroceramide
boundary condition: false
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial concentration: 1.0
type: Species

metaR DAGKn hs
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
fast: false

metaR S3TASE1ly
product: MODEL1310110016#
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_630be3d5_1632_4675_b8ed_52ebaf3c5dba
boundary condition: true
constant: false
is encoded by: hsa:AI697028
type: Species
has only substance units: false
name: _AI697028_1_e
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM thcholstoic c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB03873
constant: false
has only substance units: false
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false

metaM xoltriol m
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
is: CHEBI:16496
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457

metaM no c
is: C00533
is: HMDB03378
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Nitric oxide
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16480
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8c50d046_2938_481d_afdd_cd9a30bfde28
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFV3
type: Species
is: P56181
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4731

metaR r1434
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
name: Transport reaction
reversible: false

metaM btamp m
is: HMDB04220
name: Biotinyl-5'-AMP
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
initial amount: NaN
is: CHEBI:3110
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_adf89731_37a0_46cf_8e6d_334687df2717
initial concentration: NaN
boundary condition: true
constant: false
is: Q02252
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4329
name: ALDH6A1

metaR HS4ly
reactant: MODEL1310110016#
name: heparan-N-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110016#_c6e61e76_7302_4104_979f_2e2bb52b9574
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: PIGX
is: SBO:0000252
initial amount: NaN
is: Q8TBF5
boundary condition: true
is encoded by: hsa:54965

http://identifiers.org/biomodels.db/MODEL1310110016#_09defc5c_1d9c_460f_827e_eb21666892f0
has only substance units: false
is: P16885
boundary condition: true
type: Species
is: SBO:0000252
name: PLCG2
constant: false
initial concentration: NaN
is encoded by: hsa:5336
initial amount: NaN

metaR CEPTE
modifier: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: ethanolamine phosphotransferase
reversible: false
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.2
fast: false
reactant: MODEL1310110016#

metaM dha e
is: SBO:0000247
is: CHEBI:16016
is: HMDB01882
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial concentration: 1.0
initial amount: NaN
name: glycerone

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM glc D c
type: Species
is: HMDB00122
name: D-glucose
is: CHEBI:4167
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR MELATNOX
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
reactant: MODEL1310110016#
reversible: false
name: Melatonin:NADP oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.48
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.14.1

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM sgalside hs l
name: sulfatide galactocerebroside
is: HMDB00904
is: CHEBI:16349
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cca95ff8_57ea_44ca_a7b5_38767485ddc1
has only substance units: false
name: IVD
is: SBO:0000252
type: Species
boundary condition: true
is: B3KVI7
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:3712

http://identifiers.org/biomodels.db/MODEL1310110016#_3f593821_a4df_46ff_a392_56b29031d02b
is encoded by: hsa:56894
is: SBO:0000252
initial concentration: NaN
name: AGPAT3
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR UMPK
reversible: true
fast: false
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM Lpipecol x
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-pipecolic acid
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: CHEBI:30913
is: HMDB00716

metaR ASPNATm
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
reversible: false
name: aspartate N-acetyltransferase, mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_446dd92b_9c44_44c0_bb3e_bbfa98460e1a
is encoded by: hsa:5315
constant: false
is: P14618
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PKM2
type: Species
boundary condition: true
is: SBO:0000252

metaM o2 c
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01377
boundary condition: false
is: C00007
name: O2
is: SBO:0000247

metaR ADK3m
reversible: true
type: Reaction
name: adentylate kinase (GTP)
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000269

metaR DHCRD1
name: dihydroceramide desaturase
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR r0726
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_2d3d68c8_fdc7_4a35_a99c_7ca0961b4f99
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: NDUFS1
is: P28331
is encoded by: hsa:4719
initial concentration: NaN

metaM 2hb e
type: Species
is: CHEBI:1148
name: 2-Hydroxybutyrate
is: SBO:0000247
is: HMDB00008
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_973d6231_4d8d_4e0d_882b_edb72af66c59
constant: false
name: _U37519_1_m
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:U37519
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_039e55c7_4455_4e14_ac3a_99104e13c9c8
has only substance units: false
name: _AI971036_1_m
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AI971036
boundary condition: true
type: Species

metaM pan4p e
is: SBO:0000247
boundary condition: false
is: HMDB01416
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
type: Species
name: Pantetheine 4'-phosphate
is: CHEBI:47942
constant: false
is: C01134
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_fee01425_08ab_4ba2_ba7b_19cdbca11424
name: SLC1A4
initial concentration: NaN
constant: false
is: SBO:0000252
is: P43007
initial amount: NaN
has only substance units: false
is encoded by: hsa:6509
boundary condition: true
type: Species

metaM co2 m
type: Species
is: C00011
is: CHEBI:16526
initial concentration: 1.0
name: CO2
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN

metaM cmp m
name: CMP(2-)
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00095
boundary condition: false
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN

metaM ca2 e
is: SBO:0000247
constant: false
initial concentration: 1.0
name: calcium(2+)
type: Species
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
boundary condition: false
is: HMDB00464
is: CHEBI:29108

http://identifiers.org/biomodels.db/MODEL1310110016#_2fef9c2e_3939_431e_b0db_8b14554ac9e5
boundary condition: true
name: COX6B1
is: P14854
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1340

metaM gluside hs l
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:18368
type: Species

metaM pail hs c
has only substance units: false
boundary condition: false
is: CHEBI:57880
constant: false
type: Species
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0

metaR HAS2
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110016#
name: hyaluronan synthase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

metaR RE1522M
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1522
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR r0055
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110016#
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR ILETAm
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
name: isoleucine transaminase, mitochondrial
reactant: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#

metaM sucsal m
initial concentration: 1.0
has only substance units: false
is: HMDB01259
name: Succinic semialdehyde
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: CHEBI:57706
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false

metaR PGISr
name: Prostaglandin I2 synthase
is version of: http://identifiers.org/ec-code/5.3.99.4
product: MODEL1310110016#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134

metaR r0321
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.3.5.2
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110016#
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
has only substance units: false
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: SBO:0000247
is: HMDB01166
is: CHEBI:57316
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR RPE
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
is: SBO:0000176
type: Reaction
name: ribulose 5-phosphate 3-epimerase

http://identifiers.org/biomodels.db/MODEL1310110016#_6a4b956e_08c7_4565_b4f7_304bbd7a8e7e
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: RRM1:RRM2
is encoded by: hsa:6240
initial concentration: NaN
constant: false
has part: P23921
has part: P31350
is encoded by: hsa:6241
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110016#_6525643c_3d9f_48d1_a1e6_7f349b8d1ee9
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: B7Z2M9
constant: false
name: DGKZ
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8525
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_117b8312_5da2_46ee_8cf9_543125ff8d28
initial concentration: NaN
is: Q15067
boundary condition: true
initial amount: NaN
name: ACOX1
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:51
constant: false

metaR LNLCCPT2
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
modifier: MODEL1310110016#

metaM pail34p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57658
initial concentration: 1.0
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM duri c
initial amount: NaN
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
initial concentration: 1.0
is: HMDB00012
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
is: C00526

metaM cys L e
constant: false
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
type: Species
is: CHEBI:17561
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00574
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_820b2cf4_d4cf_4ba8_bf7d_929bc9f42009
name: ACAA2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P42765
initial amount: NaN
is encoded by: hsa:10449
constant: false
type: Species

metaM for e
initial amount: NaN
name: formate
constant: false
is: HMDB00142
is: CHEBI:15740
is: SBO:0000247
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM o2 e
is: SBO:0000247
constant: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: HMDB01377
is: C00007
type: Species
has only substance units: false
initial concentration: 1.0
name: O2
boundary condition: false

metaM cys L c
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: L-cysteine
has only substance units: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM pan4p c
name: Pantetheine 4'-phosphate
is: HMDB01416
type: Species
initial amount: NaN
initial concentration: 1.0
is: C01134
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaR r1365
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_bf85373b_3b10_4982_8964_aef13bb20aba
initial concentration: NaN
is encoded by: hsa:50
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: ACO2
type: Species
initial amount: NaN
is: Q99798

http://identifiers.org/biomodels.db/MODEL1310110016#_2ad64948_b46d_4924_9427_d7d681b90e8a
name: ACAD8
is: Q6ZWP6
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:27034

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110016#
modifier: MODEL1310110016#
name: aspartate intake by system ASCT-1 transporter
reversible: false
product: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6bb9fa14_7c24_4d3b_9201_10580973fe60
is: SBO:0000252
boundary condition: true
name: PLA2G5
is encoded by: hsa:5322
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: P39877

http://identifiers.org/biomodels.db/MODEL1310110016#_601d789b_e09c_44a3_80c2_ef05b0b077bf
is: SBO:0000252
is: P07205
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: PGK2
initial amount: NaN
is encoded by: hsa:5232
has only substance units: false

metaM m2gacpail hs r
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
type: Species
constant: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
initial amount: NaN
boundary condition: false

metaR NP1
name: nucleotide phosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c3fcc33f_4390_4bb3_b618_514d58c31678
is: A0PJH2
initial amount: NaN
name: ATP5H
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:10476
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_57e8d7cb_f9eb_460c_88d9_8a06f30e86a5
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2876
name: GPX1
has only substance units: false
initial concentration: NaN
is: P07203

metaM ca2 c
is: CHEBI:29108
name: calcium(2+)
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
is: HMDB00464
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_20c0e8d4_1163_4a71_9fb7_43425b946611
initial concentration: NaN
constant: false
type: Species
is: O95674
has only substance units: false
is encoded by: hsa:8760
boundary condition: true
name: CDS2
is: SBO:0000252
initial amount: NaN

metaR IDOURte
reactant: MODEL1310110016#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: L-iduronate transport, extracellular
fast: false

metaR DOCO13EFATP
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaM acglcgalgluside hs g
initial amount: NaN
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
constant: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17103
is: SBO:0000247

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR GALC
product: MODEL1310110016#
name: Galactocerebrosidase
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.46
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is: SBO:0000176

metaR r0720
is described by: ECO:0000000
reactant: MODEL1310110016#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110016#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM 2hb c
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:1148
is: HMDB00008
name: 2-Hydroxybutyrate
has only substance units: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_4b3e1db9_ac0d_4400_a52f_152e1e41e1bc
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:T83654
has only substance units: false
constant: false
name: _T83654_1_m

metaR DM ethamp r
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR ACHEe
is version of: http://identifiers.org/ec-code/3.1.1.7
modifier: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Acetylcholinesterase
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
type: Reaction

metaR r1364
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#

metaM msa m
has only substance units: false
initial concentration: 1.0
is: CHEBI:33190
boundary condition: false
is: HMDB11111
name: 3-oxopropanoate
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5099a8fe_cad9_4b20_86c0_d5b42847bd27
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: AADAT
initial amount: NaN
is: Q8N5Z0
is encoded by: hsa:51166
boundary condition: true
type: Species

metaM dutp c
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00460
type: Species
constant: false
is: CHEBI:17625
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110016#_86f2bcd1_542c_4288_b325_4019221ce185
initial concentration: NaN
name: SLC16A2
is: SBO:0000252
is encoded by: hsa:6567
type: Species
has only substance units: false
is: P36021
boundary condition: true
initial amount: NaN
constant: false

metaR RE0908C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
reversible: true
kinetic law: MODEL1310110016#
type: Reaction
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
name: RE0908
is: SBO:0000176

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM lac L x
is: CHEBI:16651
name: (S)-lactate
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN

metaM cmp g
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00095
name: CMP(2-)
constant: false
is: CHEBI:60377
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_0b55f0d4_ad41_41b8_8043_9fad18cc8aa3
boundary condition: true
is: P21912
has only substance units: false
initial amount: NaN
name: SDHB
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6390
type: Species

metaR FUT12g
is: SBO:0000176
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.1.69
is described by: ECO:0000269
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c3ecb3f4_bbc5_4fa3_a614_605bb9005bfb
has only substance units: false
boundary condition: true
is: Q96GD0
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: PDXP
is: SBO:0000252
is encoded by: hsa:57026

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: false
is: SBO:0000176
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
product: MODEL1310110016#

metaM for c
initial concentration: 1.0
is: C00058
initial amount: NaN
name: Formate
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
is: HMDB00142
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaM creat m
is: CHEBI:16919
initial amount: NaN
initial concentration: 1.0
constant: false
name: creatine
type: Species
is: HMDB00064
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false

metaR DADNt4
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110016#
type: Reaction
name: deoxyadenosine transport via diffusion
kinetic law: MODEL1310110016#
is described by: ECO:0000000

metaR B MANNASEly
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110016#
name: beta-mannosidase, lysosomal
is: SBO:0000176
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.25
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction

metaM xol7ah2al c
has only substance units: false
is: CHEBI:27428
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
has only substance units: false
is: CHEBI:57326
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01269
constant: false
boundary condition: false

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
initial amount: NaN
is: CHEBI:58332
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_87513fcf_0d53_4ae0_9f6e_41be0fbc8e4c
type: Species
boundary condition: true
is: SBO:0000252
name: ATP1A3
is encoded by: hsa:478
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B7Z2T0

metaR r1431
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_81be1892_3dab_47da_b509_41ce592ab7a3
initial concentration: NaN
is encoded by: hsa:5238
is: SBO:0000252
is: B4DX94
name: PGM3
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM CE5117 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:12947

metaR 3AIBTm
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110016#
name: L-3-aminoisobutyrate transaminase, mitochondrial
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR BGLUTCHLe
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM pe hs r
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
name: phosphatidylethanolamine
type: Species
initial amount: NaN
is: CHEBI:16038
has only substance units: false

metaR HMGCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
type: Reaction
fast: false
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
product: MODEL1310110016#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a401292d_9733_4780_9f8d_aef7333dcd15
constant: false
is: P23634
is: SBO:0000252
name: ATP2B4
is encoded by: hsa:493
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR PYRt2p
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
fast: false
modifier: MODEL1310110016#
name: pyruvate peroxisomal transport via proton symport
product: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_16ee13b8_2233_456d_8656_fb27ee9f5293
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6390
is: P21912
name: SDHB

http://identifiers.org/biomodels.db/MODEL1310110016#_284d6a68_2a26_4e6b_93f4_93211cd0a5e5
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has part: Q06055
has only substance units: false
is: SBO:0000297
is encoded by: hsa:517

http://identifiers.org/biomodels.db/MODEL1310110016#_750392ff_8ac3_4e15_8973_9157272a4b4d
boundary condition: true
is: SBO:0000252
name: FUCA1
initial amount: NaN
is: P04066
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2517

metaR HYXNt
product: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
name: Hypoxanthine transport
modifier: MODEL1310110016#

metaR CHOLESACATc
type: Reaction
name: esterification of cholesterol to cholesterol ester within enterocytes
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.26
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
is described by: ECO:0000134
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176

metaR r0722
is version of: http://identifiers.org/ec-code/4.2.3.12
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000

metaM ppi x
has only substance units: false
constant: false
initial concentration: 1.0
name: Diphosphate
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00250
is: C00013

metaR r2199
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: true

metaR r0149
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
is described by: ECO:0000000

metaR FOLt2le
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110016#
name: folate transport via anion exchange
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaM hs deg11 l
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
is: HMDB00868
initial amount: NaN
name: heparan sulfate, degradation product 11
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57737
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR r2118
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR PROt4 2 r
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
reversible: true
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000006
modifier: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#

metaM 5fthf m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
name: 5-formyltetrahydrofolate(2-)
is: CHEBI:57457
is: SBO:0000247
constant: false
type: Species

metaR PPAm
name: inorganic diphosphatase
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110016#

metaR S6TASE19ly
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110016#

metaR q10h2tc
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of ubiquinol into cytosol
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_e3214959_6340_4873_bb02_8156ae6e11a8
is encoded by: hsa:3155
is: Q6IBC0
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: HMGCL

metaM 4nph e
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57917
name: 4-nitrophenolate
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232

metaM dgmp e
initial amount: NaN
is: HMDB01044
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: dGMP(2-)
is: CHEBI:57673
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_c8f4f09b_1652_4444_9b39_67762b9b5af3
name: RRM2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6241
initial concentration: NaN
type: Species
is: P31350

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM h2o2 e
is: CHEBI:16240
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
boundary condition: false
is: SBO:0000247

metaM o2 n
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
constant: false
name: dioxygen
is: HMDB01377
initial amount: NaN

metaR MMCDm
is: SBO:0000176
reactant: MODEL1310110016#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.9
product: MODEL1310110016#
fast: false
is described by: ECO:0000212
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
type: Reaction

metaR BTNt4i
reversible: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is described by: ECO:0000269
fast: false
type: Reaction
name: Biotin uptake (antiport)
is: SBO:0000185
kinetic law: MODEL1310110016#

metaR NDPK1
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP)
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaM HC00460 c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
type: Species
boundary condition: false
constant: false
name: 2,5-dihydroxybenzoate
initial amount: NaN
is: SBO:0000247
is: CHEBI:58044

metaM tyr L c
is: HMDB00158
has only substance units: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17895
initial amount: NaN
name: L-tyrosine

metaM ksii core2 deg6 l
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:12936
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_91d326cd_d45d_4dfb_95cf_f58b4cd6bb7e
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
name: ENPP3
boundary condition: true
type: Species
initial concentration: NaN
is: Q308M7

metaM abt e
type: Species
boundary condition: false
name: L-arabinitol
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
is: CHEBI:18403
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01851

metaR r2117
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110016#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110016#

metaR r0360
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_4836b89e_4f76_457c_b6cd_ac59ed24abbb
is: SBO:0000252
has only substance units: false
constant: false
name: _AI656480_1_m
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI656480
boundary condition: true

metaR LCADi
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110016#
reversible: false
name: lactaldehyde dehydrogenase
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_fce98851_d01d_42ac_8805_1f8db3a516d6
initial concentration: NaN
is encoded by: hsa:9963
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC23A1
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_3df99de2_2344_4129_90b6_57980e0894fc
initial amount: NaN
is: Q9HAS3
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:64078
initial concentration: NaN
name: SLC28A3

metaR GALASE10ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
product: MODEL1310110016#
fast: false

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000269

metaM nadh m
type: Species
boundary condition: false
constant: false
is: C00004
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
initial concentration: 1.0
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
is: CHEBI:57945

metaM o2 m
name: O2
is: CHEBI:15379
initial amount: NaN
is: C00007
is: SBO:0000247
has only substance units: false
is: HMDB01377
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
constant: false
boundary condition: false

metaM asn L m
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
type: Species
is: HMDB00168
initial concentration: 1.0
is: CHEBI:17196
name: L-asparagine
boundary condition: false
has only substance units: false
initial amount: NaN

metaR MI1P Dtn
product: MODEL1310110016#
fast: false
name: inositol 1-phosphate nuclear transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110016#
type: Reaction
reversible: true

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM thbpt c
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial concentration: 1.0
type: Species
name: 5,6,7,8-tetrahydrobiopterin
is: CHEBI:15372
is: HMDB00027
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2056
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
modifier: MODEL1310110016#

metaR r0974
is: SBO:0000185
name: Active transport
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:

metaR RE3568C
type: Reaction
is described by: ECO:0000000
name: RE3568
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaM ala B m
name: beta-alanine
is: HMDB00056
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
boundary condition: false
is: CHEBI:16958
initial concentration: 1.0
has only substance units: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM dcdp m
type: Species
constant: false
is: HMDB01245
name: dCDP(3-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58593
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

http://identifiers.org/biomodels.db/MODEL1310110016#_57f1145b_0dc9_4be4_b5fb_7bb3ec645066
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q5JRA6
boundary condition: true
name: MIA3
is encoded by: hsa:375056
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_3a45f13f_a1ed_4360_82cd_26729503bdb4
name: HAS2
initial concentration: NaN
constant: false
is encoded by: hsa:3037
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q92819
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_de1462c0_0e12_4900_8343_cc058f996441
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AV717590
type: Species
name: _AV717590_1_c
initial concentration: NaN
has only substance units: false

metaR r2198
reversible: true
is: SBO:0000185
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#

metaR BILIRUBtr
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
type: Reaction
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110016#
is described by: ECO:0000000

metaR r2119
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110016#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110016#

metaR NDPK3
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#

metaR r0027
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaM Tn antigen g
is: SBO:0000247
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
name: Tn antigen
initial concentration: 1.0
is: C04383
has only substance units: false
initial amount: NaN
boundary condition: false

metaR RTOTAL2t
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: RTOTAL2 transport
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaM abt c
is: HMDB01851
type: Species
name: L-arabinitol
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_71140ef7_c7e1_4d84_98c8_a8b8f8954b4f
name: NDUFA2
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4695
constant: false
is: SBO:0000252
is: O43678

http://identifiers.org/biomodels.db/MODEL1310110016#_fe3a6dc8_56d5_44e2_92be_1ef9b821d22c
type: Species
initial amount: NaN
name: PTGS2
is encoded by: hsa:5743
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P35354
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_a7865f8f_2047_41a5_9621_c6516b2d91d1
has only substance units: false
constant: false
name: NDUFA6
type: Species
is encoded by: hsa:4700
boundary condition: true
is: P56556
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR THBPT4ACAMDASE
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110016#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false
type: Reaction

metaR r0973
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110016#_4bb7a0b4_e729_4a47_91c2_4a18c596527d
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: BPNT1
is: SBO:0000252
is encoded by: hsa:10380
initial concentration: NaN
has only substance units: false
is: O95861

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM tyr L e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17895
constant: false
name: L-tyrosine
initial amount: NaN
type: Species
is: HMDB00158
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaM HC01403 m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
boundary condition: false
is: CHEBI:28325
initial concentration: 1.0
has only substance units: false
constant: false
name: (S)-Hydroxydecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110016#_2904738b_88f4_4fd4_be77_4b996990e490
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: ACO1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:48
is: P21399

metaR r2054
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110016#
fast: false
is: SBO:0000185

metaM prostgf2 e
is: CHEBI:57404
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin F2alpha(1-)
is: HMDB01139
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9913fd5c_e401_490b_887b_3f433135be3a
is: Q9Y345
name: SLC6A5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9152
boundary condition: true
type: Species
has only substance units: false

metaR NDPK4
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
product: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_eb812fcd_f328_47b6_aaeb_59fa10a4bf2f
boundary condition: true
is encoded by: hsa:7991
name: TUSC3
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q13454

metaR CK
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
name: ATP Creatine kinase
is version of: http://identifiers.org/ec-code/2.7.3.2
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1159.1) or (1160.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:1917943,PMID:2914937 NOTES:kegg C02305 MJC

metaM thyox L e
has only substance units: false
is: CHEBI:18332
initial amount: NaN
is: HMDB00248
boundary condition: false
is: SBO:0000247
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
constant: false
type: Species

metaR TSTSTERONEtr
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
is: SBO:0000185
reactant: MODEL1310110016#
name: testosterone intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0145
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is version of: http://identifiers.org/ec-code/1.8.3.1
reversible: true
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c5ed1202_8945_4d52_9cdf_87d666b55752
initial concentration: NaN
is encoded by: hsa:79751
type: Species
constant: false
is: Q9H936
is: SBO:0000252
has only substance units: false
name: SLC25A22
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_870d708a_b872_4d7a_9400_57bc8ea78b62
type: Species
is encoded by: hsa:3707
constant: false
has only substance units: false
boundary condition: true
is: P27987
name: ITPKB
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_7a39017b_4012_4100_aa60_c319eb8f3aca
is: B4DG68
initial amount: NaN
has only substance units: false
is encoded by: hsa:4842
type: Species
initial concentration: NaN
name: NOS1
constant: false
is: SBO:0000252
boundary condition: true

metaM doco13ecoa c
has only substance units: false
name: 13-docosenoylcoa
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/24892791
boundary condition: false
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false

metaM pmtcoa c
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
is: HMDB01338
initial amount: NaN
type: Species
is: C00154
has only substance units: false
initial concentration: 1.0

metaM hista e
is: SBO:0000247
is: HMDB00870
boundary condition: false
is: CHEBI:58432
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
constant: false
initial concentration: 1.0
name: histamium
has only substance units: false

metaR LPASE
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176
name: lysophospholipase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.5
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction

metaM 5adtststerone c
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
initial amount: NaN

metaM nadph r
is: SBO:0000247
is: C00005
initial concentration: 1.0
is: CHEBI:57783
is: HMDB00221
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false

metaR B3GNT39g
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR BTNDm
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
name: biotinidase (biotin), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT

metaM acmana r
has only substance units: false
name: N-acetyl-D-mannosamine
constant: false
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
boundary condition: false
initial concentration: 1.0
is: HMDB01129
type: Species
is: SBO:0000247
initial amount: NaN

metaM prostgi2 c
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57403
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)

metaR r2055
reversible: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NDPK5
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dGDP)

http://identifiers.org/biomodels.db/MODEL1310110016#_360b1fe7_4a55_4b8a_947f_1d43a927103b
boundary condition: true
initial amount: NaN
constant: false
is: P51178
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5333
has only substance units: false
name: PLCD1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_7d8c9c28_d05d_4d38_8d23_7e670e4048bf
is: SBO:0000252
boundary condition: true
type: Species
is: O95168
initial concentration: NaN
name: NDUFB4
is encoded by: hsa:4710
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_428de58a_48f7_41a2_b1b7_e87ad30bf2fe
name: GPX2
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: P18283
type: Species
is encoded by: hsa:2877
is: SBO:0000252
boundary condition: true

metaM CE4790 m
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
is: CHEBI:12947
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR FAS140COA
is described by: ECO:0000269
product: MODEL1310110016#
modifier: MODEL1310110016#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
type: Reaction
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110016#

metaM C02470 c
boundary condition: false
has only substance units: false
is: HMDB00881
type: Species
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5485
name: Xanthurenic acid
initial amount: NaN
is: C02470
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_38204dc9_825e_4b94_8f9f_9f11ad4c4303
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: E9PDK1
name: SLC4A9
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:83697
boundary condition: true

metaR SFGTH
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.2.12
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
reversible: true
name: S-Formylglutathione hydralase

http://identifiers.org/biomodels.db/MODEL1310110016#_15c1957a_4e19_449a_9ad1_61b71a56e27c
is: SBO:0000252
boundary condition: true
name: DPYSL3
initial concentration: NaN
type: Species
is encoded by: hsa:1809
initial amount: NaN
has only substance units: false
constant: false
is: Q8IXW6

http://identifiers.org/biomodels.db/MODEL1310110016#_5a133430_91ec_4273_9daf_50664041c521
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: ATP5G3
is encoded by: hsa:518
initial concentration: NaN
is: P48201
type: Species

metaR r1154
fast: false
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
name: EC:1.2.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_a5c9218b_cafd_4640_a691_4e213ac79443
is: O60331
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23396
constant: false
name: PIP5K1C
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR r0400
type: Reaction
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_21410238_7b37_49be_b9de_2dda34a0f006
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1962
type: Species
name: EHHADH
constant: false
boundary condition: true
is: Q9NY65

http://identifiers.org/biomodels.db/MODEL1310110016#_ec08e697_7a84_4f01_a6ea_b84d68b8b385
boundary condition: true
name: NOS3
is: A0S0A7
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4846
initial concentration: NaN

metaR THMP
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000
name: thiamin phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD

metaM dcdp n
boundary condition: false
initial amount: NaN
name: dCDP(3-)
is: HMDB01245
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
type: Species
constant: false
initial concentration: 1.0

metaR r1747
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM 3aib c
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB02166
boundary condition: false
is: SBO:0000247

metaR P450SCC1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
fast: false
name: cholesterol monooxygenase
reversible: true
is described by: ECO:0000134

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
is: C00526
is: HMDB00012
name: Deoxyuridine
is: SBO:0000247
initial amount: NaN
is: CHEBI:16450
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_f1754b72_5477_44c2_b539_49cb58a6e8d7
type: Species
name: INPP5J
initial concentration: NaN
is: Q15735
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27124
boundary condition: true
initial amount: NaN
constant: false

metaM prostgh2 r
has only substance units: false
initial concentration: 1.0
name: prostaglandin H2(1-)
is: CHEBI:57405
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01381
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaR PRO Dtde
kinetic law: MODEL1310110016#
name: D-proline transport, extracellular
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR NDPK6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110016#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110016#

metaM HC01118 r
name: presqualene diphosphate(3-)
type: Species
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 4abutn m
initial amount: NaN
has only substance units: false
is: HMDB01080
is: SBO:0000247
is: CHEBI:58264
name: 4-ammoniobutanal
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaM prostgf2 c
initial amount: NaN
is: CHEBI:57404
name: prostaglandin F2alpha(1-)
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB01139
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaM thyox L c
constant: false
type: Species
is: CHEBI:18332
boundary condition: false
initial amount: NaN
is: HMDB00248
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r1260
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: EC:6.2.1.3
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

metaR CYSGLUexR
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110016#
type: Reaction
reversible: true
name: L-cysteine/L-glutamine reversible exchanger

http://identifiers.org/biomodels.db/MODEL1310110016#_c790be71_b25c_46fc_babb_a91f9dd82dc0
has only substance units: false
name: SLC7A5
is: SBO:0000252
type: Species
is: Q8IV97
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8140
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_47e6aafc_996e_4c0f_b926_efa2ffb98165
has only substance units: false
is encoded by: hsa:6576
type: Species
initial concentration: NaN
name: SLC25A1
initial amount: NaN
is: SBO:0000252
is: D9HTE9
boundary condition: true
constant: false

metaM h2o2 c
is: CHEBI:16240
initial amount: NaN
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
boundary condition: false
constant: false
is: HMDB03125
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_122ef0d8_06d6_4c9b_a2aa_3954cf7a7fc1
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5279
is encoded by: hsa:51227
constant: false
has part: B2RAU6
boundary condition: true
is encoded by: hsa:9091
initial amount: NaN
has only substance units: false
is: SBO:0000297
has part: P57054
is encoded by: hsa:5277
type: Species
initial concentration: NaN

metaM hista c
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
is: HMDB00870
is: CHEBI:58432
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: histamium

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR DCK2n
reactant: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (UTP)
fast: false
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_d4b49e3f_22de_441e_8fde_b938f82c4dcc
initial concentration: NaN
name: SLC22A4
boundary condition: true
is: Q9H015
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:6583

http://identifiers.org/biomodels.db/MODEL1310110016#_14e4658f_5fd7_45b1_997a_77d78a9d6343
type: Species
is: Q16795
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4704
boundary condition: true
initial amount: NaN
constant: false
name: NDUFA9
is: SBO:0000252

metaR ACGAMK
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
name: N-acetylglucosamine kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.59
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110016#

metaM HC00718 c
initial concentration: 1.0
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaM dgmp c
boundary condition: false
is: CHEBI:57673
constant: false
initial concentration: 1.0
name: dGMP
is: C00362
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
is: SBO:0000247
has only substance units: false

metaM 5adtststerone e
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02961
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR FACOAL204
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110016#
name: fatty-acid--CoA ligase
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR NDPK7
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110016#
name: nucleoside-diphosphate kinase (ATP:dCDP)
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_a8bda86b_f35b_460d_92e2_d57650e4ee96
boundary condition: true
initial amount: NaN
is encoded by: hsa:2182
is: SBO:0000252
constant: false
is: O60488
has only substance units: false
type: Species
initial concentration: NaN
name: ACSL4

metaM prostgi2 e
is: CHEBI:57403
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
name: prostaglandin I2(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c9a17dd4_d425_490c_b106_fb7de90411ac
initial amount: NaN
is encoded by: hsa:4694
is: SBO:0000252
constant: false
has only substance units: false
is: Q6IBB5
boundary condition: true
type: Species
name: NDUFA1
initial concentration: NaN

metaR FE3MTP1
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
is described by: ECO:0000134
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reversible: false
name: transport of ferrous iron into blood
type: Reaction

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110016#

metaM pydx5p c
is: CHEBI:597326
boundary condition: false
is: SBO:0000247
is: C00018
initial amount: NaN
name: Pyridoxal 5'-phosphate
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
constant: false
type: Species
is: HMDB01491
has only substance units: false
initial concentration: 1.0

metaR r2053
reversible: false
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:35418
name: N-acetylneuraminate
is: HMDB00230
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE2269E
is described by: ECO:0000000
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
name: RE2269
type: Reaction
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110016#

metaM nadp m
has only substance units: false
initial concentration: 1.0
is: CHEBI:58349
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
boundary condition: false
is: C00006
type: Species
initial amount: NaN

metaR CHOLtu
name: Choline uniport
is described by: ECO:0000269
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110016#
modifier: MODEL1310110016#

metaR UAGDP
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.7.23
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110016#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_b245e39d_efd1_45e3_b3b1_790fb27adb76
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:1158
constant: false
is: SBO:0000252
is: B2R892
has only substance units: false
name: CKM

metaR TMDK1
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
name: thymidine kinase (ATP:thymidine)
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_941d9973_d7d7_4f7c_848f_b7f2d57e225b
is: Q5K4L6
constant: false
name: SLC27A3
initial concentration: NaN
is encoded by: hsa:11000
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9c590b44_c866_4f62_a4d7_a3c4259a3110
initial concentration: NaN
is: Q5MY95
is: SBO:0000252
name: ENTPD8
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:377841

http://identifiers.org/biomodels.db/MODEL1310110016#_5f1acded_bec7_4902_aa4b_1080f2230edb
type: Species
is: SBO:0000252
constant: false
is: Q9NRF8
is encoded by: hsa:56474
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: CTPS2

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_68ba301c_cc58_4319_baf8_fb7037f3eeeb
boundary condition: true
initial amount: NaN
has only substance units: false
is: P04745
name: AMY1C
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:278
is: SBO:0000252

metaR RE1804M
is: SBO:0000176
reactant: MODEL1310110016#
name: RE1804
product: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
is: SBO:0000247
constant: false
is: C00035
name: GDP
type: Species
is: CHEBI:58189
is: HMDB01201
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM o2 x
is: C00007
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
initial amount: NaN
initial concentration: 1.0
name: O2
boundary condition: false
is: HMDB01377

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM retinal cis 13 r
name: 13-cis-retinal
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
constant: false
is: HMDB06220
is: SBO:0000247

metaM 4abutn c
initial amount: NaN
is: CHEBI:58264
is: SBO:0000247
is: C00555
constant: false
initial concentration: 1.0
is: HMDB01080
boundary condition: false
name: 4-Aminobutanal
has only substance units: false
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaM dcmp c
is: CHEBI:57566
name: dCMP
initial concentration: 1.0
is: HMDB01202
has only substance units: false
is: C00239
boundary condition: false
constant: false
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
initial amount: NaN

metaM nadh c
is: HMDB01487
constant: false
name: Nicotinamide adenine dinucleotide - reduced
type: Species
has only substance units: false
is: C00004
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:57945
initial amount: NaN

metaR RE1810M
fast: false
reactant: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1810
reversible: true
kinetic law: MODEL1310110016#
type: Reaction

metaR r1639
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#

metaM citr L c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
name: L-citrulline
has only substance units: false
is: CHEBI:16349
type: Species
initial amount: NaN
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110016#_dfb7e038_9afb_4980_9844_8837c63a6da9
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ALDH7A1
initial concentration: NaN
has only substance units: false
constant: false
is: E7EPT3
is encoded by: hsa:501

metaR r1861
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR KAS8
is: SBO:0000176
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000269
product: MODEL1310110016#
reversible: false
name: b-ketoacyl synthetase (palmitate, n-C16:0)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_918de0ab_cf3d_4fc0_aa8c_7ae85c5bdee7
is: Q9H845
initial concentration: NaN
is: SBO:0000252
name: ACAD9
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:28976

http://identifiers.org/biomodels.db/MODEL1310110016#_cec0e5d1_c393_42a2_817e_cbb904aa8695
is: O00330
initial amount: NaN
name: PDHX
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8050
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaM h2o2 n
is: CHEBI:16240
is: HMDB03125
boundary condition: false
initial concentration: 1.0
name: hydrogen peroxide
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_74f00ab5_a5e4_46d2_b627_ebe00eca73fa
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM acgam c
is: HMDB00215
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110016#_477a6c3f_728c_42dc_835f_f5119c105f52
name: _BE042354_1_m
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BE042354

metaM thym c
is: HMDB00262
is: CHEBI:17821
has only substance units: false
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00178
name: Thymine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ff59ca3c_a3d6_4d0a_b154_77741db48e95
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4724
is: SBO:0000252
initial amount: NaN
is: O43181
has only substance units: false
constant: false
name: NDUFS4

metaR KCC2t
is described by: ECO:0000269
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
type: Reaction

metaM leuktrE4 c
type: Species
is: HMDB02200
initial concentration: 1.0
is: CHEBI:57462
constant: false
initial amount: NaN
name: leukotriene E4(1-)
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

http://identifiers.org/biomodels.db/MODEL1310110016#_f8da54ce_855a_4bdb_8424_30ff40f8b73b
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9091
is: SBO:0000252
name: PIGQ
is: Q9BRB3

metaM asn L c
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
initial amount: NaN
is: CHEBI:17196
constant: false
type: Species
name: L-asparagine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_94a16170_6b15_4dad_a5ac_6f43055b4a97
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:498
is: B4DY56
type: Species
initial concentration: NaN
has only substance units: false
name: ATP5A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_a51763df_1934_4147_8a36_fa1a2b2a2155
has only substance units: false
constant: false
name: SLC24A4
is encoded by: hsa:123041
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaM glyc3p x
type: Species
is: C00093
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
initial concentration: 1.0
is: CHEBI:57597
constant: false
boundary condition: false
is: HMDB00126
has only substance units: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1638
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
reactant: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_830d5c71_4c08_4d73_87e2_81df31c63c45
is: P49914
boundary condition: true
initial concentration: NaN
name: MTHFS
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10588
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_0e47b63d_5722_4676_a93a_d0c21120eb15
is encoded by: hsa:AI539321
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AI539321_1_c
constant: false

metaR r1860
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaM apoC Lys c
boundary condition: false
is: CHEBI:32551
initial concentration: 1.0
is: HMDB00182
type: Species
has only substance units: false
name: Apocarboxylase (Lys residue)
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_64d03343_5743_47b3_9462_075411e722e2
initial amount: NaN
boundary condition: true
is: A8MU28
is: SBO:0000252
type: Species
constant: false
name: NAE1
is encoded by: hsa:8883
has only substance units: false
initial concentration: NaN

metaM h2o2 m
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00027
is: CHEBI:16240
name: Hydrogen peroxide
initial amount: NaN
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110016#_f32da9f1_1784_4900_afed_169866e3d990
name: PLCB4
boundary condition: true
is encoded by: hsa:5332
initial concentration: NaN
has only substance units: false
constant: false
is: Q15147
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_d8718a32_eeee_4da9_b0a2_9b6e2a3b7dca
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: B3KMA6
is: SBO:0000252
is encoded by: hsa:2181
boundary condition: true
name: ACSL3

metaR DM T antigen g
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaM HC01223 m
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57340
type: Species
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial concentration: 1.0
has only substance units: false

metaR r0822
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185

metaM 6htststerone e
initial concentration: 1.0
is: C14497
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
type: Species
name: 6 beta hydroxy testosterone
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/17395497
initial amount: NaN
is: SBO:0000247
is: HMDB06259
boundary condition: false

metaR UDPGLCAter
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
type: Reaction
reversible: true
modifier: MODEL1310110016#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ce59e079_ce09_4a1e_81b4_557f9161ee44
is: Q5SYN6
name: SLC22A3
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6581

metaR r0821
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110016#
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_227e1c8a_cbc3_4544_8f98_5f7467e9ff52
type: Species
is: B3KVA3
is: SBO:0000252
name: RDH13
constant: false
initial concentration: NaN
is encoded by: hsa:112724
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_a13a0818_9cd4_4871_ab5d_73d7ac037e0e
constant: false
boundary condition: true
name: SLC5A9
type: Species
is encoded by: hsa:200010
initial amount: NaN
is: E9PAK4
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR RNDR1
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
type: Reaction
fast: false
is: SBO:0000176

metaM ppi r
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:33019
is: C00013
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
name: Diphosphate
constant: false
is: HMDB00250

metaM citr L e
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: CHEBI:16349
is: HMDB00904
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: citr_L[e]

metaR XOLTRIOLtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
name: lipid, flip-flop intracellular transport

metaR MTHFD2m
is: SBO:0000176
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is described by: ECO:0000254
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR MMSAD3m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial

metaR r0512
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3

metaM xu1p D c
name: D-Xylulose 1-phosphate
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
type: Species
is: HMDB06534
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM nadp r
constant: false
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
type: Species
boundary condition: false
is: C00006
has only substance units: false
initial concentration: 1.0
is: CHEBI:58349
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247

metaM dgdp n
has only substance units: false
is: SBO:0000247
name: dGDP(2-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
is: CHEBI:58595
is: HMDB00960
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b54a7828_5e1d_4e0c_a6b0_d7c066068535
is encoded by: hsa:5335
type: Species
constant: false
boundary condition: true
is: P19174
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PLCG1
is: SBO:0000252

metaM pcrn m
name: propionyl-carnitine
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00824
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM CE4872 m
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR MI3PP
name: myo-inositol 3-phosphatase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
fast: false
modifier: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a5ddc80d_ddab_474c_9122_ce7462386b75
initial amount: NaN
is encoded by: hsa:7084
name: TK2
type: Species
is: SBO:0000252
is: O00142
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM orot e
constant: false
is: CHEBI:30839
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5e305db5_7a98_4b8c_b76b_2327366d5e07
is encoded by: hsa:80308
has only substance units: false
type: Species
name: FLAD1
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a8743724_321d_402a_af7e_9b651df1a016
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: CHAT
is encoded by: hsa:1103
is: P28329
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM asn L e
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
name: L-asparagine
boundary condition: false
is: HMDB00168
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM leuktrE4 e
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
boundary condition: false
is: SBO:0000247
name: leukotriene E4(1-)
is: HMDB02200
type: Species

metaM xol27oh r
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17703
initial amount: NaN
is: SBO:0000247
name: 26-hydroxycholesterol
is: HMDB02103
has only substance units: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

metaR HACD1m
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM gdp n
has only substance units: false
is: HMDB01201
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58189
name: GDP(3-)
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_cc88ad32_4b9d_4ba2_a3cd_69738f5943f4
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:229
is: P05062
type: Species
name: ALDOB
has only substance units: false
boundary condition: true

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR XOL27OHtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_630b0ef9_16fa_4f4b_a5f7_669b47f9d6e9
type: Species
name: CA12
initial concentration: NaN
has only substance units: false
is encoded by: hsa:771
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O43570
constant: false

metaR PPAt
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: Propionate transport, diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_f43f1d86_3a38_4030_ad35_39bf89d286f6
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54963
is: Q53HM1
has only substance units: false
initial amount: NaN
name: UCKL1

metaR VALt5m
name: Valine reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
fast: false

metaM prostgi2 r
name: prostaglandin I2(1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
is: HMDB01335
is: SBO:0000247
constant: false
is: CHEBI:57403
initial amount: NaN
type: Species

metaM dcdp c
initial concentration: 1.0
constant: false
has only substance units: false
name: dCDP
boundary condition: false
is: C00705
is: CHEBI:58593
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: HMDB01245
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_1a24454b_0e2b_448b_be2a_54513ea26df6
initial concentration: NaN
is encoded by: hsa:257202
constant: false
boundary condition: true
is: P59796
type: Species
name: GPX6
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_1d8257a4_e725_41b7_a9a5_aa4279fd75ea
initial concentration: NaN
is: Q7Z4L0
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:341947
constant: false
name: COX8C
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_ba9f0f73_f1e1_4331_b1ab_c33bf5d722c9
constant: false
has only substance units: false
is encoded by: hsa:5742
initial amount: NaN
boundary condition: true
is: P23219
name: PTGS1
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_1b9c8e8f_48ac_447b_bff0_4e31bdb82b98
is: P48735
constant: false
name: IDH2
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:3418

http://identifiers.org/biomodels.db/MODEL1310110016#_ffa1e1e5_ca6c_4481_9657_ceba12694063
initial amount: NaN
initial concentration: NaN
name: _T83654_1_e
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:T83654

metaR ACACt2m
name: Acetoacetate mitochondrial transport via H+ symport
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
is: SBO:0000185
product: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is described by: ECO:0000269
type: Reaction

metaR LPS3e
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
type: Reaction
name: lipase, extracellular
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM ibcoa m
boundary condition: false
is: HMDB01243
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
constant: false
is: CHEBI:57338
has only substance units: false
name: isobutyryl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_5c2f3eb8_f1ef_457e_9451_3204d67bdb2c
is encoded by: hsa:1836
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: SLC26A2
is: P50443
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_6d1bfec5_fb47_4400_9287_03838298ee6d
has only substance units: false
is encoded by: hsa:54
boundary condition: true
is: P13686
initial amount: NaN
name: ACP5
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaM xol27oh m
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:17703
is: SBO:0000247
is: HMDB02103
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
name: 26-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110016#_93582a76_b264_426d_b124_2e733da1daed
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:515
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR SERtN1
reversible: true
is described by: ECO:0000269
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM orot c
type: Species
is: CHEBI:30839
initial concentration: 1.0
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
name: Orotate
is: HMDB00226
is: SBO:0000247
has only substance units: false
is: C00295
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cd09b498_e7fd_4ee9_8417_1b26970002e0
is encoded by: hsa:8613
type: Species
name: PPAP2B
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O14495
has only substance units: false

metaM ksi deg3 l
name: keratan sulfate I, degradation product 3
boundary condition: false
is: HMDB01356
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57312
initial amount: NaN

metaR CHOLtn
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: Choline transport, nuclear through pores
fast: false
type: Reaction
is described by: ECO:0000000

metaM duri m
is: CHEBI:16450
is: HMDB00012
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: 2'-deoxyuridine
constant: false
has only substance units: false
is: SBO:0000247

metaR r2347
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110016#
fast: false
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110016#_271c224c_c417_4a06_8545_db2ad67c00de
boundary condition: true
initial amount: NaN
name: SLC26A11
type: Species
initial concentration: NaN
is encoded by: hsa:284129
has only substance units: false
constant: false
is: Q86WA9
is: SBO:0000252

metaR HSAT4ly
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6e73b4ef_016d_4363_9abe_b6d5ba3a5fdc
is encoded by: hsa:38
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
name: ACAT1
is: P24752
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_bf91dcb7_e228_4342_b9c5_fdc6670f3d85
has only substance units: false
type: Species
is: P36269
constant: false
name: GGT5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2687
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_6d447b58_9b7e_4fe7_a6f6_81a2b4643704
name: GBA
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:2629
is: B7Z6S9
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_0b5ca0d6_1230_43ed_9da8_27bac9ba44fe
is encoded by: hsa:23007
boundary condition: true
has only substance units: false
name: PLCH1
is: Q4KWH8
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_173c9d2d_fe15_4209_b0d2_b0cd7b28aeb2
is encoded by: hsa:2584
constant: false
is: P51570
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: GALK1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_1b5b217d_1708_491b_91e4_7fb55afca123
has only substance units: false
initial concentration: NaN
is encoded by: hsa:FLJ44968
constant: false
initial amount: NaN
name: _FLJ44968_1_m
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_d3dfa534_d7a8_414d_ba35_0d2f3d65aeb0
constant: false
is encoded by: hsa:8310
type: Species
is: SBO:0000252
name: ACOX3
initial amount: NaN
is: O15254
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM so4 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
name: sulfate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_19ab75f1_86a2_48fb_a417_49ca2c131d25
constant: false
is: P22033
name: MUT
is encoded by: hsa:4594
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM duri n
initial concentration: 1.0
is: HMDB00012
is: CHEBI:16450
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
name: 2'-deoxyuridine

http://identifiers.org/biomodels.db/MODEL1310110016#_c6956ce3_622e_485c_826f_e1a4c91c6ee7
name: ACAA2
is: P42765
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10449

metaR RE3004M
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110016#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: RE3004
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_aff527f8_c59d_42bf_bcbb_834415cd3eab
is: SBO:0000297
initial amount: NaN
name: SLC3A2:SLC7A6
initial concentration: NaN
has only substance units: false
constant: false
type: Species
has part: Q92536
boundary condition: true
is encoded by: hsa:9057

metaM phe L e
is: HMDB00159
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
is: CHEBI:17295
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_df4b62f0_f093_4e83_8b7d_eb4bc873c0c1
type: Species
name: RDH5
is: SBO:0000252
is encoded by: hsa:5959
constant: false
initial amount: NaN
is: Q92781
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1864
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR CYTK11n
kinetic law: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110016#

metaR ASCBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: L-ascorbate transport via facilitated diffusion
fast: false
reversible: true
reactant: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#

metaM 4abutn e
initial amount: NaN
has only substance units: false
boundary condition: false
name: 4-ammoniobutanal
is: HMDB01080
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247

metaM o2 r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
boundary condition: false
name: O2
is: C00007
type: Species
constant: false
has only substance units: false
is: CHEBI:15379
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_2283b25c_1e59_4a78_b0d3_f06a029ea353
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: CHKB
is: SBO:0000252
has only substance units: false
is: A0PJM6
is encoded by: hsa:1120

metaR ORNLEUrBATtc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR RE0512M
reversible: true
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE0512

metaM trdox c
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:18191
name: Oxidized thioredoxin
is: C00343
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

http://identifiers.org/biomodels.db/MODEL1310110016#_82de69d4_406e_4a3e_aec2_58c3772bca84
is encoded by: hsa:54981
name: NMRK1
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q9NWW6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_0157c66c_3c9b_4287_87f6_1ed2bc7c7541
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:220
name: ALDH1A3
type: Species
boundary condition: true
constant: false
is: P47895
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_500d6f4e_3106_4dd2_a57d_68938d3a2af8
is: SBO:0000297
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
boundary condition: true
constant: false
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110016#_005c591f_a90d_496d_94d9_2bdec4fd2f43
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9551
type: Species
name: ATP5J2
is: F8W7V3
constant: false
boundary condition: true

metaM pmtcoa m
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
is: CHEBI:57379
initial amount: NaN
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
is: C00154
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_24be6abd_6fcb_4cf1_a024_bd826a5ffe46
is encoded by: hsa:7083
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P04183
constant: false
name: TK1
initial amount: NaN
type: Species
initial concentration: NaN

metaM dlnlcgcoa c
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
has only substance units: false
is: CHEBI:27979
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_61631176_ed31_46a0_9601_9e04b7fe9143
is: P05091
type: Species
name: ALDH2
has only substance units: false
is encoded by: hsa:217
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR NDPK4n
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110016#_a0c37a27_5c54_4e17_8731_398509a04f96
is: SBO:0000252
is: P55084
initial concentration: NaN
name: HADHB
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:3032
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e6f8e9bc_0deb_4924_8c3e_67ed7df34bbd
initial amount: NaN
is: B1AK53
has only substance units: false
is encoded by: hsa:83715
constant: false
type: Species
initial concentration: NaN
name: ESPN
is: SBO:0000252
boundary condition: true

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
initial concentration: 1.0
is: HMDB01448
is: CHEBI:16189
constant: false
is: SBO:0000247
name: sulfate
initial amount: NaN
type: Species
boundary condition: false

metaR XYLt
fast: false
reversible: true
product: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
name: D-xylose reversible transport
kinetic law: MODEL1310110016#
type: Reaction

metaR CYTK3n
is: SBO:0000176
product: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM 6htststerone c
is: HMDB06259
is: http://identifiers.org/pubchem.compound/17395497
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C14497
has only substance units: false
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
name: 6 beta hydroxy testosterone

metaR CLFORtex
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: chloride transport via formate countertransport
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
fast: false
is: SBO:0000185
is described by: ECO:0000304
type: Reaction

metaR r1642
modifier: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110016#_c6486a7e_78f5_4090_8234_ee690e142e6c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:60386
name: SLC25A19
boundary condition: true
constant: false
is: SBO:0000252
is: Q9HC21

metaR RE0912C
fast: false
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: RE0912
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (25830.1) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10199779,PMID:11397879,PMID:12039030,PMID:8767510,PMID:9463486 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#

metaM oaa c
is: CHEBI:3338
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00223
has only substance units: false
name: Oxaloacetate
is: C00036
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2

metaM ksii core4 l
name: keratan sulfate II (core 4-linked)
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01644
is: CHEBI:17140
has only substance units: false
boundary condition: false
constant: false

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: RE1518

metaM prostgh2 e
is: HMDB01381
name: prostaglandin H2(1-)
type: Species
is: SBO:0000247
is: CHEBI:57405
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
initial amount: NaN
constant: false

metaR r2535
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110016#_1e575dcd_8532_4a85_82f8_5407f376383c
initial concentration: NaN
constant: false
is: Q9UJS0
initial amount: NaN
is encoded by: hsa:10165
name: SLC25A13
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6a4ca54a_5015_44d4_bb4f_9d62969013aa
name: _22305_1_c
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:22305
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR SMPD4
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
name: sphingomyelinase
reactant: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f1f82ce0_f2a5_4346_ad3f_dee406aab30b
has only substance units: false
initial concentration: NaN
is encoded by: hsa:124
is: P07327
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: ADH1A
boundary condition: true

metaR r0604
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
reversible: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
modifier: MODEL1310110016#
fast: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176

metaR r2344
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110016#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_8283796f_bd26_47f9_9cb6_b95dd5e4d2c7
is: Q96P26
is encoded by: hsa:93034
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NT5C1B

http://identifiers.org/biomodels.db/MODEL1310110016#_cb9ddb4a_5393_468d_9203_11157325d1c5
is encoded by: hsa:2731
type: Species
has only substance units: false
is: P23378
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: GLDC
constant: false
boundary condition: true

metaM amp m
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:456215
is: SBO:0000247
type: Species
is: HMDB00045
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_665a9ef8_6753_438d_80cd_ddd6377791a9
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q674R7
is encoded by: hsa:285973
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: ATG9B

http://identifiers.org/biomodels.db/MODEL1310110016#_497c69b4_2d49_4dc0_bd6d_f02a485bd0a3
initial amount: NaN
name: CDIPT
is: SBO:0000252
is: A8K3L7
constant: false
is encoded by: hsa:10423
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM pcrn c
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
has only substance units: false
name: propionyl-carnitine
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR AKR1D2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110016#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_a08e8f8b_1d18_4bc5_9fd6_911f9cc45d6c
has only substance units: false
is encoded by: hsa:4860
initial amount: NaN
is: SBO:0000252
is: P00491
constant: false
initial concentration: NaN
name: PNP
type: Species
boundary condition: true

metaR GALGT1
is described by: ECO:0000269
is: SBO:0000176
name: Beta-1,4 N-acetylgalactosaminyltransferase
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.1.92
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES:NJ
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaR GCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
product: MODEL1310110016#
type: Reaction

metaR GALASE18ly
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110016#
name: beta-galactosidase, lysosomal
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r1643
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#

metaR RE1531M
fast: false
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE1531

http://identifiers.org/biomodels.db/MODEL1310110016#_2a03b0cf_d3a1_43b4_8ccc_6bd0d78c9d3f
is: Q9BV79
initial concentration: NaN
is encoded by: hsa:51102
initial amount: NaN
is: SBO:0000252
name: MECR
boundary condition: true
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_625956af_851a_49fc_9320_f6c2b82b37be
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q5TDP6
type: Species
boundary condition: true
constant: false
is encoded by: hsa:51557
name: LGSN

metaR r0472
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
is: SBO:0000176

metaM doco13ecoa x
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: 13-docosenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_24b8bb04_898c_4b29_87e8_587efe908ff5
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: CPT1B
is: Q53FV7
initial concentration: NaN
is encoded by: hsa:1375
is: SBO:0000252

metaM chsterol c
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
name: cholesterol
is: CHEBI:16113
type: Species
is: HMDB00067
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_0a44963b_b78e_43d0_a222_5bd546253141
boundary condition: true
is: P49441
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: INPP1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3628

metaR RE3624M
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110016#
name: RE3624
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_8d43b060_454a_4e03_962d_644305627b4d
initial amount: NaN
boundary condition: true
type: Species
name: _AA854479_1_m
is encoded by: hsa:AA854479
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR FAS80COA L
reactant: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r0475
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110016#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM prostgh2 c
is: HMDB01381
type: Species
constant: false
is: CHEBI:57405
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
name: prostaglandin H2(1-)
initial amount: NaN

metaR r1644
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
modifier: MODEL1310110016#

metaM bamppald c
is: SBO:0000247
name: beta-Aminopropion aldehyde
has only substance units: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7975
is: HMDB01106
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
constant: false
is: C05665
boundary condition: false
initial concentration: 1.0

metaM gdp g
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: CHEBI:58189
boundary condition: false
has only substance units: false
name: GDP(3-)
type: Species

metaR IDOAASE3ly
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5f3ee7b4_3b2d_483a_bef5_8abd7aedc157
is encoded by: hsa:1119
has only substance units: false
boundary condition: true
constant: false
name: CHKA
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r2346
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaM q10 m
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01072
is: CHEBI:46245
type: Species
name: ubiquinone-10
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
initial concentration: 1.0

metaR r1400
reactant: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: Active transport
kinetic law: MODEL1310110016#
reversible: false
fast: false
product: MODEL1310110016#

metaR S6TASE26ly
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_4e1d5ed5_75dc_4154_8c40_dbbd0f0dc0ea
is encoded by: hsa:3631
initial amount: NaN
is: Q96PE3
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: INPP4A

metaR LEUyLAThtc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM focytC m
boundary condition: false
type: Species
constant: false
is: CHEBI:16928
name: Ferrocytochrome C
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_4e5c32b1_82e0_45db_81f4_164c1025ca69
boundary condition: true
has only substance units: false
initial amount: NaN
is: O95992
initial concentration: NaN
is encoded by: hsa:9023
constant: false
is: SBO:0000252
name: CH25H
type: Species

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR PROSTGE2t
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_ce682df2_0702_493b_bae9_face715c8709
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2882
type: Species
boundary condition: true
name: GPX7
is: Q96SL4
initial concentration: NaN

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM nadph c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
type: Species
is: C00005
is: HMDB00221
is: CHEBI:57783
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_822cd5e3_3d32_4342_b4c8_e9ce56a0444e
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR r0474
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110016#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110016#

metaR r1645
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaM 3aib m
constant: false
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
is: HMDB02166
initial concentration: 1.0
is: CHEBI:33094
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_cc8e24e0_5c6b_4c55_960d_0c8c23bab25f
constant: false
is: P36269
name: GGT5
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2687
type: Species
initial concentration: NaN

metaR 3MOBt2im
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

metaR r0603
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.12
reactant: MODEL1310110016#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
modifier: MODEL1310110016#

metaM gacpail hs r
is: C00092
name: glucosaminyl-acylphosphatidylinositol
type: Species
boundary condition: false
is: CHEBI:61548
is: HMDB01401
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaM andrstandn r
name: 5alpha-androstane-3,17-dione
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00899
boundary condition: false
is: CHEBI:15994
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674

http://identifiers.org/biomodels.db/MODEL1310110016#_86f2b925_d3ed_4e67_883d_42aacde4607e
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:145226
initial amount: NaN
has only substance units: false
is: Q96NR8
boundary condition: true
name: RDH12

metaM 34dhphe e
name: L-dopa
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15765
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
type: Species
is: HMDB00181

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR r2534
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110016#

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reactant: MODEL1310110016#
reversible: true
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110016#

metaM h2o2 x
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: HMDB03125
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: Hydrogen peroxide
is: SBO:0000247
is: C00027
is: CHEBI:16240

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM xol7ah c
initial amount: NaN
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: CHEBI:2290
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
boundary condition: false
is: HMDB06892
type: Species
initial concentration: 1.0
constant: false

metaM citr L m
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16349
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
is: HMDB00904
type: Species

metaM chsterol e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
name: cholesterol
type: Species
constant: false

metaR CHOLtg
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
name: choline intracellular transport
type: Reaction
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_084534c8_ae3f_4b07_88c8_645ea292e17a
boundary condition: true
initial amount: NaN
is encoded by: hsa:60482
is: Q9GZV3
type: Species
name: SLC5A7
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR FAOXC121x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR AGPAT1
product: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.3.1.15
fast: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_a4f32360_72d5_42b6_aa32_8011265112cd
is: O75715
name: GPX5
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2880
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM nh4 e
initial amount: NaN
has only substance units: false
is: CHEBI:28938
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium

metaM dgdp m
is: CHEBI:58595
name: dGDP(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00960
constant: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247

metaM idour c
is: CHEBI:21338
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
boundary condition: false
is: HMDB02704
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1646
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
modifier: MODEL1310110016#

metaR RE0926E
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110016#
name: RE0926
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true

metaR UAG4E
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.1.3.2

metaM leu L c
initial amount: NaN
name: L-leucine
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00687
has only substance units: false
is: CHEBI:15603

W3 CDTF: Thu Aug 30 09:33:28 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110016#_3dcfdb9d_5f62_4730_8ae4_ff75e08f0beb
name: DUT
constant: false
is encoded by: hsa:1854
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P33316
type: Species
has only substance units: false

metaM spmd c
is: SBO:0000247
constant: false
name: Spermidine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
boundary condition: false
is: CHEBI:57834
type: Species
is: C00315
has only substance units: false
is: HMDB01257

metaR ALADGLNexR
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000304
product: MODEL1310110016#

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_015b0476_db1d_4467_91a5_2125459e4393
boundary condition: true
name: SLC36A1
initial amount: NaN
is encoded by: hsa:206358
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: Q1LZ56
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_1710d6a1_972a_420b_ae11_e994206b805b
type: Species
is encoded by: hsa:AI191472
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AI191472_1_c
initial amount: NaN

metaM ppi m
name: Diphosphate
is: SBO:0000247
is: CHEBI:33019
has only substance units: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110016#_ec3f0bfe_1061_4bc1_84d6_3ee7d1c01bad
is: P04745
is: SBO:0000252
name: AMY1B
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:277

metaR APOCFm
reactant: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: Apocarboxylase formation, mitochondrial
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
type: Reaction
product: MODEL1310110016#

metaR ARSA
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110016#
modifier: MODEL1310110016#
name: Arylsulfatase A
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110016#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.8

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:27668
constant: false
initial amount: NaN

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: HMDB01039
type: Species
boundary condition: false
constant: false
has only substance units: false
is: C01328
name: hydroxide ion
is: SBO:0000247
initial concentration: 1.0

metaR r2532
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_61ca7ec3_965c_4d85_8f06_29b90ae7d069
is encoded by: hsa:498
is: SBO:0000297
constant: false
initial amount: NaN
is encoded by: hsa:509
has part: Q6I9V2
has only substance units: false
has part: P25705
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
type: Species

metaM CE2421 m
constant: false
has only substance units: false
is: CHEBI:30623
type: Species
is: SBO:0000247
is: HMDB02329
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA

metaM nadh x
initial concentration: 1.0
is: CHEBI:57945
has only substance units: false
constant: false
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
type: Species
initial amount: NaN
is: HMDB01487
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_ddb61d3d_1e1f_4e86_b962_11a8a9b0186f
name: ADSSL1
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q8N142
is encoded by: hsa:122622
has only substance units: false
boundary condition: true

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r0502
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
modifier: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110016#

metaM leu L e
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00687
is: CHEBI:15603
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
has only substance units: false
constant: false
name: L-leucine

metaR r1647
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110016#

metaM ksi deg16 l
type: Species
name: keratan sulfate I, degradation product 16
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
boundary condition: false
is: CHEBI:16953
initial amount: NaN
is: HMDB00812
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_e5fb14c8_dbde_45f6_aa3f_317abecd88fe
is encoded by: hsa:275
is: SBO:0000252
name: AMT
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: P48728
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c9717f4c_c5e9_45fd_8b6d_80d8594f614b
name: ALDH4A1
is encoded by: hsa:8659
type: Species
is: P30038
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

W3 CDTF: Thu Aug 30 09:34:13 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110016#_a6e72a64_ed1d_4c0e_b372_97b2b59065bf
name: SPTLC2
constant: false
initial concentration: NaN
has only substance units: false
is: O15270
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:9517

metaM mi134p c
is: HMDB01143
is: CHEBI:58414
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bd67cd1e_669b_480b_b0d0_5d17b714345c
initial amount: NaN
name: OGDHL
boundary condition: true
has only substance units: false
is: Q9ULD0
is encoded by: hsa:55753
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR 3SPYRSP
type: Reaction
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000

metaR NOt
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110016#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
name: NO transport (diffusion)
is described by: ECO:0000000

metaM ksi deg9 l
is: HMDB00143
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 9
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR GGT5r
type: Reaction
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
modifier: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000134
product: MODEL1310110016#
name: Gamma-glutamyltransferase 5

http://identifiers.org/biomodels.db/MODEL1310110016#_979a1608_a9e0_41c1_adf7_1ba48b40f2f3
is: B3KXY9
type: Species
initial amount: NaN
is encoded by: hsa:3098
name: HK1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM gdp c
constant: false
is: CHEBI:58189
name: GDP
initial concentration: 1.0
boundary condition: false
is: HMDB01201
has only substance units: false
type: Species
is: SBO:0000247
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

metaM idour e
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: CHEBI:21338
is: HMDB02704
constant: false
name: L-iduronate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM nmn c
has only substance units: false
name: NMN
is: SBO:0000247
is: C00455
initial concentration: 1.0
constant: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:14649

metaM pre prot r
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial amount: NaN
type: Species
is: HMDB03125
is: CHEBI:16240
has only substance units: false
initial concentration: 1.0
notes: FORMULA: XY CHARGE: 0
is: SBO:0000247
boundary condition: false
constant: false

metaR CRNCARtp
product: MODEL1310110016#
fast: false
name: carnitine-acetylcarnitine carrier, peroxisomal
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110016#

metaR RE1709C
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
name: RE1709
is: SBO:0000176
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
reactant: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a3008c3e_f43a_413d_ae61_0434bfa2f7e8
type: Species
constant: false
name: TKT
is encoded by: hsa:7086
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E7EPA7
has only substance units: false

metaR PETOHMm hs
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is described by: ECO:0000254
type: Reaction
reversible: false
fast: false
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
name: phosphatidylethanolamine N-methyltransferase

metaM mi1345p c
is: HMDB01059
is: SBO:0000247
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57895
boundary condition: false
initial concentration: 1.0
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
constant: false

metaR CYSTGLUex
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110016#
reversible: false
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
fast: false
name: L-cystine/L-glutamate exchanger
product: MODEL1310110016#

metaM spmd e
has only substance units: false
initial amount: NaN
name: Spermidine
type: Species
is: CHEBI:57834
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: C00315
boundary condition: false
is: HMDB01257
is: SBO:0000247
constant: false

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaR r1648
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185

metaR P45027A11m
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
product: MODEL1310110016#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_7d9df967_9bda_4116_8cca_36457baee5a8
boundary condition: true
has part: P48201
type: Species
initial concentration: NaN
is encoded by: hsa:518
constant: false
initial amount: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
has only substance units: false
type: Species
boundary condition: false
name: hydroxide ion
initial amount: NaN
is: HMDB01039
constant: false
is: C01328
initial concentration: 1.0
is: SBO:0000247

metaM thym e
name: thymine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:17821
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
constant: false
is: HMDB00262
type: Species

metaR FAOXC141C121x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM nh4 c
is: C01342
is: SBO:0000247
initial amount: NaN
is: CHEBI:28938
is: HMDB00051
initial concentration: 1.0
name: Ammonium
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_471dbfda_4e14_474c_9c92_f008f70eb257
name: NME1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4830
constant: false
initial amount: NaN
is: P15531

http://identifiers.org/biomodels.db/MODEL1310110016#_59a22d40_4a79_4f73_8224_3728b2b13f1a
constant: false
is: O15382
initial concentration: NaN
name: BCAT2
type: Species
initial amount: NaN
is encoded by: hsa:587
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM acgam6p c
is: CHEBI:57513
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
has only substance units: false
constant: false
is: HMDB01062

http://identifiers.org/biomodels.db/MODEL1310110016#_1fec2503_e807_40db_925b_7724edef62e2
initial amount: NaN
is: Q8N0X4
name: CLYBL
is: SBO:0000252
boundary condition: true
is encoded by: hsa:171425
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR DHCR72r
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: 7-dehydrocholesterol reductase
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
product: MODEL1310110016#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

metaM fuc1p L c
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: SBO:0000247
type: Species
is: CHEBI:28319
is: HMDB01265
has only substance units: false
name: L-Fucose 1-phosphate
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR r2341
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110016#

metaM ksi deg40 l
name: keratan sulfate I, degradation product 40
is: HMDB00143
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:12936
notes: FORMULA: C40H68N2O31 CHARGE: 0

metaM ppi n
is: CHEBI:33019
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: diphosphate(3-)
boundary condition: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
is: SBO:0000247

metaR r0504
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_02908c10_3ecb_4330_959c_e228ae9e0e37
has only substance units: false
constant: false
name: ATP5J
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:522
boundary condition: true

metaM ha e
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: hyaluronan
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
initial concentration: 1.0
is: CHEBI:16336

metaR GULN3D
is: SBO:0000176
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
name: L-gulonate 3-dehydrogenase

W3 CDTF: Thu Aug 30 09:33:28 BST 2012

metaR r1649
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f6b4c8fd_b36d_46bb_b6fa_47a176a7e764
has part: O14521
initial amount: NaN
has only substance units: false
type: Species
has part: P31040
initial concentration: NaN
constant: false
boundary condition: true
has part: Q99643
is encoded by: hsa:6390
is encoded by: hsa:6392
is: SBO:0000297
name: SDHA:SDHB:SDHC:SDHD
has part: P21912
is encoded by: hsa:6391
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110016#_7e0b46a9_3f4d_4e13_98ae_cd6eae41753d
is: Q86U05
type: Species
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC7A8
initial amount: NaN
constant: false

metaR MMTSADm
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

metaM 5mthf c
is: CHEBI:3729
constant: false
has only substance units: false
is: HMDB01396
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN

metaM HC00591 c
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16769
initial amount: NaN
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaM nadph m
type: Species
is: C00005
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57783

metaR GALASE6ly
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110016#

metaR PI4PLCn
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

metaM chsterol l
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: cholesterol
is: CHEBI:16113
is: HMDB00067

http://identifiers.org/biomodels.db/MODEL1310110016#_c258d62f_f2d1_4fed_b81e_804d3dd1f8b8
initial amount: NaN
name: ADH1A:ADH1B
boundary condition: true
initial concentration: NaN
has part: P07327
type: Species
has only substance units: false
is encoded by: hsa:124
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_59760d1f_4679_467b_860e_41e390647d61
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6120
type: Species
boundary condition: true
is: SBO:0000252
name: RPE
constant: false
is: Q96AT9

metaM ha l
type: Species
initial amount: NaN
constant: false
name: hyaluronan
is: CHEBI:16336
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
is: SBO:0000247

metaR GPDDA1
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110016#
fast: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_6ccb3c5d_7548_41b1_a11d_fe56e81afbbf
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:7001
type: Species
name: PRDX2
boundary condition: true
initial concentration: NaN

metaR r1755
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaM mescoa m
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Mesaconyl-CoA
type: Species
initial amount: NaN
constant: false
is: CHEBI:27969
is: C06028
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_22c778cc_5ee3_44ac_ab00_e059ec271731
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PPA2
is encoded by: hsa:27068
initial amount: NaN
type: Species
is: F8WDN9

metaR r0142
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is described by: ECO:0000000
reversible: false

metaM fe2 c
name: Fe2+
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00692
constant: false
is: CHEBI:29033
initial concentration: 1.0
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247

metaR MI4PP
is: SBO:0000176
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7ed0b944_6698_4a38_b1ca_6ccccb5d06fa
is encoded by: hsa:8399
name: PLA2G10
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: O15496
initial amount: NaN
boundary condition: true

metaR r2419
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_ebc31a71_09ca_4162_821e_cc9ba499e476
is: P49753
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10965
constant: false
initial amount: NaN
name: ACOT2

metaR ALR2
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
name: aldose reductase (methylglyoxal)
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
reactant: MODEL1310110016#

metaR CDSm
is version of: http://identifiers.org/ec-code/2.7.7.41
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM gd1c hs e
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
name: GD1c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB00138

http://identifiers.org/biomodels.db/MODEL1310110016#_1922f8ae_e760_4122_84b2_a1b4194d5b34
initial concentration: NaN
name: SLC25A15
type: Species
is: Q9Y619
is encoded by: hsa:10166
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM hdca r
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
has only substance units: false
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
is: C00249
type: Species
initial concentration: 1.0
is: HMDB00220
initial amount: NaN
boundary condition: false
constant: false

metaM ala B c
boundary condition: false
name: beta-alanine
is: SBO:0000247
is: HMDB00056
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
type: Species
has only substance units: false
initial concentration: 1.0

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
fast: false
is: SBO:0000185

metaM acmana e
is: SBO:0000247
constant: false
is: HMDB01129
boundary condition: false
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: CHEBI:17122
initial concentration: 1.0
initial amount: NaN
type: Species
name: N-acetyl-D-mannosamine

metaR r2110
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110016#

metaR TPI
reversible: true
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.1
fast: false
kinetic law: MODEL1310110016#
name: triose-phosphate isomerase
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110016#
is described by: ECO:0000134
product: MODEL1310110016#

metaM chlstol r
is: HMDB06842
initial amount: NaN
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16290

http://identifiers.org/biomodels.db/MODEL1310110016#_1d44d413_d8da_4f56_a418_d4e6f22e83dd
is encoded by: hsa:3295
is: E9PB82
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: HSD17B4
has only substance units: false
constant: false
is: SBO:0000252

metaR GD1Ctg
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
name: gd1c hs intracellular transport
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_b50dbaf4_8297_4bec_872e_3584360ebf4c
is encoded by: hsa:2639
initial concentration: NaN
type: Species
name: GCDH
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q92947
is: SBO:0000252

metaM HC01115 c
has only substance units: false
type: Species
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
is: CHEBI:29025
initial concentration: 1.0
initial amount: NaN
name: NeuNGc
is: SBO:0000247
boundary condition: false

metaM HC02121 c
is: CHEBI:58758
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
boundary condition: false
initial amount: NaN
constant: false
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_38b773fd_94b5_4621_b847_6fb24e5e668d
is: SBO:0000252
type: Species
is encoded by: hsa:23236
has only substance units: false
initial concentration: NaN
is: Q9NQ66
initial amount: NaN
constant: false
boundary condition: true
name: PLCB1

metaR ITCOAL1m
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110016#
reversible: true
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110016#_9f467b80_dbef_490f_a9d1_7ea39bc5e19f
is: SBO:0000252
boundary condition: true
name: _AI824319_1_r
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI824319
initial amount: NaN

metaR r0755
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#

W3 CDTF: Thu Aug 30 09:34:13 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110016#_47c8bb26_5f63_4fad_9538_4967bd016bc9
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SYNJ1
constant: false
is encoded by: hsa:8867
is: O43426
initial concentration: NaN

metaM man6p c
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01078
is: SBO:0000247
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate
has only substance units: false
type: Species

metaM 3aib e
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
is: SBO:0000247
is: HMDB02166
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_fc0bd990_b3f5_4444_8ec2_7717b426c359
name: PMM1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:5372
is: A8K003
has only substance units: false

metaR Coqe
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
type: Reaction
name: Transport of q10
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000185

metaR VALATB0tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6a3bab9f_fd50_4f88_8734_e0ea0bd9d849
initial amount: NaN
is: P35790
constant: false
is encoded by: hsa:1119
name: CHKA
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r2111
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110016#
fast: false

metaM zymst r
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:18252
constant: false
is: HMDB06271
name: zymosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437

metaR NACHEX16ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
fast: false

metaR AKGMALtm
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
product: MODEL1310110016#
fast: false
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#

metaM g3pc c
is: CHEBI:16870
is: SBO:0000247
initial amount: NaN
type: Species
name: sn-Glycero-3-phosphocholine
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB00086

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM 5mthf e
has only substance units: false
is: HMDB01396
is: SBO:0000247
boundary condition: false
type: Species
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
constant: false
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
initial concentration: 1.0

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reversible: true
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false

metaR UMPK4n
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110016#
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269

metaM fad c
constant: false
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
has only substance units: false
initial concentration: 1.0
is: HMDB01248
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16238

metaR 5MTHFt2le
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
fast: false
name: 5-methyltetrahydrofolate transport via anion exchange

metaM gd1c hs g
has only substance units: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: CHEBI:58235
type: Species
initial concentration: 1.0
name: GD1c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00138
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_393f7a42_0377_4f65_988e_aab4c0cc030e
is: SBO:0000252
is: Q12882
constant: false
initial concentration: NaN
boundary condition: true
name: DPYD
initial amount: NaN
is encoded by: hsa:1806
type: Species
has only substance units: false

metaM ala B e
has only substance units: false
is: CHEBI:16958
initial concentration: 1.0
name: beta-alanine
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species

metaM dgsn c
boundary condition: false
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
initial amount: NaN
is: C00330
initial concentration: 1.0
name: Deoxyguanosine
is: SBO:0000247
is: HMDB00085
has only substance units: false
type: Species

metaR RDH3a
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110016#
name: retinol dehydrogenase (11-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
modifier: MODEL1310110016#
fast: false

metaM chsterol m
is: HMDB00067
initial amount: NaN
type: Species
is: CHEBI:16113
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
has only substance units: false
name: cholesterol

metaM amp r
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00020
constant: false
is: CHEBI:456215
type: Species
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
name: AMP
initial amount: NaN

metaM C05957 r
type: Species
is: SBO:0000247
is: CHEBI:27485
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
has only substance units: false
name: Prostaglandin J2
is: HMDB02710
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7c742b9e_0ea3_40a4_abb4_32114c4d1e86
is encoded by: hsa:54363
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: Q9UJM8
name: HAO1

http://identifiers.org/biomodels.db/MODEL1310110016#_6e0b3842_1367_49f0_b763_9e7cc0b25a4d
initial amount: NaN
boundary condition: true
is: B4DYG5
has only substance units: false
is encoded by: hsa:5297
type: Species
initial concentration: NaN
name: PI4KA
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_ed92501b_3740_4a17_a7ed_61d8bacf5eb1
initial concentration: NaN
is: Q16851
constant: false
initial amount: NaN
is encoded by: hsa:7360
is: SBO:0000252
name: UGP2
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e92f529c_e1da_4d9c_ba90_92cb70bc19b0
name: DECR1
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1666
initial amount: NaN
boundary condition: true
is: Q16698
is: SBO:0000252
has only substance units: false

metaM cyan e
is: HMDB02084
is: CHEBI:18407
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: hydrogen cyanide
boundary condition: false

metaR r1377
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
type: Reaction
is described by: ECO:0000000

metaR r2112
product: MODEL1310110016#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_464172b5_7e8a_4487_94d9_19b8e2548bdb
initial concentration: NaN
name: GALNT1
has only substance units: false
is encoded by: hsa:2589
is: SBO:0000252
is: Q10472
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR RE1709N
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
product: MODEL1310110016#
name: RE1709
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#

metaM ppi e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
is: CHEBI:33019
has only substance units: false
constant: false
is: HMDB00250
type: Species

metaR r2113
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f749dc7e_ee89_47fc_95e1_876aeaf4ebba
constant: false
name: TXNRD1
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR GALASE15ly
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM fgam c
is: CHEBI:58426
initial concentration: 1.0
constant: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
type: Species
is: SBO:0000247
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: C04376
is: HMDB01308
has only substance units: false
boundary condition: false
initial amount: NaN

metaR NDPK10
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false

metaM nadp c
is: CHEBI:58349
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
is: C00006
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_255ba43d_7f0b_48ce_a5ac_4d3c63aeec03
type: Species
is: O14732
boundary condition: true
is encoded by: hsa:3613
is: SBO:0000252
initial concentration: NaN
constant: false
name: IMPA2
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_67a38a6c_157f_4a08_9c0b_44f6c30105ee
is: B4DK61
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:51
initial amount: NaN
boundary condition: true
name: ACOX1

metaR S6TASE22ly
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110016#_bad2b42f_a1c0_466a_9587_1f3c06fb1562
has only substance units: false
initial amount: NaN
is encoded by: hsa:6535
is: SBO:0000252
is: B4DIA3
initial concentration: NaN
type: Species
name: SLC6A8
boundary condition: true
constant: false

metaR r0021
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1c77cb89_8a41_4c6d_9e5c_bc253d578e9f
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: SLC4A3
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6508

http://identifiers.org/biomodels.db/MODEL1310110016#_52bd5595_fe17_45c8_938a_fad2420f7ef2
is: SBO:0000252
type: Species
name: G6PC3
is: Q9BUM1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:92579
initial amount: NaN
constant: false

metaM amp x
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:456215
is: HMDB00045
type: Species
initial concentration: 1.0
name: AMP
has only substance units: false
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR HS2ly
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
fast: false
kinetic law: MODEL1310110016#

metaR UDPGLCter
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185

metaM hs deg21 l
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:16126
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM malthx e
initial amount: NaN
constant: false
name: Maltohexaose
boundary condition: false
is: C01936
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
type: Species
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_47899a12_6d15_4ca4_b371_26cf72cad27e
is: Q9HAB8
is encoded by: hsa:79717
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PPCS

metaR r2114
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true

metaM ppi c
constant: false
initial amount: NaN
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
name: Diphosphate
has only substance units: false
boundary condition: false
is: C00013
is: HMDB00250

metaM 34dhphe c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00181
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:15765
constant: false
has only substance units: false
name: L-dopa

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM idour l
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
is: CHEBI:21338
is: SBO:0000247
name: L-iduronate
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM cyan c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
is: CHEBI:18407
boundary condition: false
has only substance units: false
is: SBO:0000247
name: hydrogen cyanide
type: Species
constant: false

metaM btcoa m
is: CHEBI:57371
name: Butanoyl-CoA
initial concentration: 1.0
is: C00136
constant: false
type: Species
is: HMDB01088
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaM leu L m
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
is: HMDB00687
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-leucine
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_254ab401_adb3_49b3_b811_278ea50cf232
is: P22303
name: ACHE
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:43
is: SBO:0000252

metaM arab L c
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:30849
boundary condition: false
constant: false
is: HMDB00646
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose

http://identifiers.org/biomodels.db/MODEL1310110016#_1faf3500_4c52_4869_b4c8_64ecd57e7b97
is: SBO:0000252
constant: false
has only substance units: false
name: ACY3
is encoded by: hsa:91703
type: Species
is: Q96HD9
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR HSAT1ly
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1113be9b_ec3f_432f_8eed_800be0563225
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:R06874
name: _R06874_1_r
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5ab286b7_22ed_472d_b968_880fe3b22c80
constant: false
initial amount: NaN
name: _AA021081_1_r
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA021081
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_12625eba_f0cc_403f_82de_8e3f75cd0edd
is: P21108
is encoded by: hsa:221823
is: SBO:0000252
type: Species
name: PRPS1L1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR GALt4
name: galactose transport via sodium symport
fast: false
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110016#

metaM Tn antigen l
is: C04383
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
boundary condition: false
name: Tn antigen
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM hs deg17 l
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
type: Species
is: CHEBI:21338
has only substance units: false
initial concentration: 1.0
name: heparan sulfate, degradation product 17
initial amount: NaN

metaR ST6GALNAC25
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
reversible: false
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.99.7
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ

metaR ALR3
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
name: aldose reductase (acetol)
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM ficytC m
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:15991
constant: false
is: SBO:0000247
initial amount: NaN
name: Ferricytochrome c

metaR GCC2cm
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
product: MODEL1310110016#
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110016#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_c917247c_7ca4_46a0_8341_ea28c58c154e
is: Q96RQ3
name: MCCC1
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:56922
has only substance units: false
is: SBO:0000252

metaM dcmp n
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
is: CHEBI:57566
name: dCMP(2-)

metaM oaa m
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: C00036
name: Oxaloacetate
initial concentration: 1.0
is: HMDB00223
type: Species
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: CHEBI:16452

metaM fe2 e
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Fe2+
has only substance units: false
boundary condition: false
constant: false
is: HMDB00692
type: Species
is: CHEBI:29033
is: C00023

http://identifiers.org/biomodels.db/MODEL1310110016#_e416c61c_c103_4367_a617_d436a44cc70a
boundary condition: true
initial amount: NaN
is encoded by: hsa:10861
initial concentration: NaN
constant: false
name: SLC26A1
has only substance units: false
is: SBO:0000252
type: Species

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR PYDXNK
fast: false
name: pyridoxine kinase
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.35
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR r2537
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Utilized transport
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction

metaM dgdp c
has only substance units: false
initial concentration: 1.0
is: HMDB00960
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58595
is: SBO:0000247
name: dGDP
type: Species
is: C00361
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaR r2115
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR THMMPtm
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Thiamine monophosphate transport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR r1640
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR INSTt4 2
reactant: MODEL1310110016#
product: MODEL1310110016#
name: inositol transport via sodium symport
reversible: true
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000006
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_2547a264_ca90_484a_82f4_d9c10157be70
is: SBO:0000252
constant: false
is encoded by: hsa:LOC374569
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _LOC374569_1_e
has only substance units: false
type: Species

metaR THRGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaR SARCStm
name: Sarcosine transport (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: false
product: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
fast: false

metaM gd1c hs c
is: HMDB00138
is: CHEBI:58235
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial concentration: 1.0
name: GD1c

metaR ADEt
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
name: adenine reversible transport, cytosol
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110016#

metaR FAOXC181C161x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR BAAT4x
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
reversible: false
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110016#
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
is: SBO:0000176

metaM apoC Lys m
type: Species
name: Apocarboxylase (Lys residue)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:32551
is: HMDB00182
initial concentration: 1.0

metaM mlthf m
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
is: C00143
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533
is: CHEBI:15636
boundary condition: false

metaR PCHOL HStg
name: phosphatidylcholine scramblase
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaR ACACtx
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: acetoacetate intracellular transport unknown mechanism
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR ST6GALNAC26
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000304
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
reactant: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.7
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_edaaed17_10d5_4dfa_824b_87d793c821ae
name: NDUFA7
is encoded by: hsa:4701
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6FG42
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR r2116
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110016#
fast: false
reversible: true
product: MODEL1310110016#

metaR UDPG4E
is described by: ECO:0000134
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
name: UDPglucose 4-epimerase
fast: false
kinetic law: MODEL1310110016#

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR GD1Cte
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
name: gd1c hs transport
fast: false

metaR r0022
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM ksi deg24 l
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate I, degradation product 24
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00143
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial concentration: 1.0
constant: false
type: Species

metaR r0365
kinetic law: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaM nadh r
name: NADH(2-)
is: CHEBI:57945
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01487
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004

metaR GQ1BALPHAte
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
name: gq1balpha hs transport
reversible: true
is: SBO:0000185
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_beeb02dc_da8f_4317_9f7b_993c20f01586
boundary condition: true
is: P09622
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: DLD
is encoded by: hsa:1738

metaM arab L e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30849
constant: false
is: HMDB00646
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_d9e673b8_1260_4f1d_97fd_f4c98e64a943
constant: false
has part: Q13733
is encoded by: hsa:480
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000297
name: ATP1A4:ATP1B1
has only substance units: false
initial concentration: NaN

metaR r1641
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_9dbb3498_fa03_43d9_a00c_301bd4e3c348
is encoded by: hsa:4697
initial concentration: NaN
name: NDUFA4
boundary condition: true
has only substance units: false
type: Species
is: O00483
initial amount: NaN
is: SBO:0000252
constant: false

metaR NACHEX25ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110016#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
modifier: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaM cdp n
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
is: SBO:0000247
is: CHEBI:58069
type: Species
is: HMDB01546
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ff5ec2f6_fde3_48b4_9ba5_516e10c2d12d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PC
is encoded by: hsa:5091
is: P11498
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM dhf m
is: HMDB01056
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
is: CHEBI:57451
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: dihydrofolate(2-)
type: Species

metaR CH25H
modifier: MODEL1310110016#
name: cholesterol 25-hydroxylase
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.99.38
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110016#

metaR r0139
reversible: true
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_edff4b04_1788_435d_961a_002f243813a2
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5730
initial amount: NaN
is: P41222
name: PTGDS
boundary condition: true
has only substance units: false

metaM fol c
initial concentration: 1.0
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: Folate
constant: false

metaM ha deg1 l
constant: false
has only substance units: false
name: hyaluronan degradation product 1
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16336
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaR PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110016#
name: PPD2CSPp
fast: false
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reversible: false
is described by: ECO:0000000

metaM pap g
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM ksii core2 deg9 l
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: HMDB00143
type: Species
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_a35d094c_2a34_4980_aa7c_e0e18c4295c9
name: NDUFV3
type: Species
is: SBO:0000252
is encoded by: hsa:4731
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM HC02175 e
is: CHEBI:27689
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
name: caprate
is: SBO:0000247
has only substance units: false
type: Species

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r0962
name: Facilitated diffusion
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
product: MODEL1310110016#

metaR FMNAT
name: FMN adenylyltransferase
fast: false
reactant: MODEL1310110016#
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.2
modifier: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176

metaM CE2420 m
constant: false
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: CHEBI:28387
type: Species
initial concentration: 1.0
boundary condition: false

metaR RE0383C
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110016#
name: RE0383
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is: SBO:0000176
fast: false
type: Reaction
reversible: true

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_b855d5df_4b70_448c_b1bf_e9b37f8be98e
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:10637
constant: false
has only substance units: false
name: LEFTY1
is: O75610
is: SBO:0000252
boundary condition: true

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:27809
name: L-4-hydroxyglutamic semialdehyde
type: Species
is: HMDB06556
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR LEUPHELAT2tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_9bbcdbe7_1827_43f1_be59_2ed905f58c3c
is: Q9Y2A9
boundary condition: true
is encoded by: hsa:10331
type: Species
initial concentration: NaN
name: B3GNT3
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_3d131d9d_4b67_4d3b_bb83_e8b99c7a5299
name: HAS1
is encoded by: hsa:3036
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q8IYH3
type: Species
has only substance units: false

metaM leuktrC4 c
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: leukotriene C4(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:57973
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ebdb5c6c_afcc_45eb_9139_22b28513474c
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4514
name: COX3
is: P00414

metaR SUCD1m
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
name: succinate dehydrogenase
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
kinetic law: MODEL1310110016#

metaR PNTK
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: pantothenate kinase
reactant: MODEL1310110016#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110016#_b3b6ab97_3ba4_4790_b4b3_7c68488bc7b4
has only substance units: false
is: Q9NRZ7
name: AGPAT3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:56894
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_b32bfa57_c954_4ec9_adae_c5a47b0d3428
constant: false
initial concentration: NaN
initial amount: NaN
name: GBA
is encoded by: hsa:2629
is: SBO:0000252
type: Species
is: B7Z5G2
boundary condition: true
has only substance units: false

metaM dag hs n
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
type: Species
constant: false
is: SBO:0000247
name: diglyceride
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ec7b4089_5c42_44dc_be05_26189179a111
boundary condition: true
initial concentration: NaN
is encoded by: hsa:728226
type: Species
constant: false
name: _728226_1_e
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_b2ffb545_db95_49af_8fc1_be5feef1b118
initial amount: NaN
is: Q8NEM3
boundary condition: true
is: SBO:0000252
name: SLC16A7
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:9194
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_21ceee1f_7dbc_4185_a294_865fc6e59550
has part: O94777
has part: Q14442
is encoded by: hsa:5283
boundary condition: true
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5279
is: SBO:0000297
has part: Q9BRB3
initial amount: NaN
has part: B3KUV7
is encoded by: hsa:8818
has part: Q92535
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9091
is encoded by: hsa:51227
is encoded by: hsa:5277
constant: false

metaR ABUTt2r
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000304

metaM g3p c
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3930
constant: false
boundary condition: false
is: CHEBI:58027
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: C00661
has only substance units: false
is: HMDB01112
name: Glyceraldehyde 3-phosphate

http://identifiers.org/biomodels.db/MODEL1310110016#_d6ad7acd_dd4d_4b81_84bd_4a6e0a4986eb
constant: false
name: ACSL4
is encoded by: hsa:2182
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q5JWV8
is: SBO:0000252
type: Species

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR UMPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.4.14 Confidence Level: 1 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185
name: UMP transport (ER)
reversible: true
type: Reaction
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_56ed9462_f7fc_43b6_9649_eb4771cf1c52
name: SLC25A10
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9UBX3
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1468

http://identifiers.org/biomodels.db/MODEL1310110016#_30274b4d_b183_490c_b18d_8eaf3bdb0e5e
boundary condition: true
name: CYP1A2
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1544
is: SBO:0000252
type: Species
is: P05177

http://identifiers.org/biomodels.db/MODEL1310110016#_f09d1788_f8f7_4f04_a6f8_27ea7e68060f
boundary condition: true
constant: false
name: _AI480132_1_c
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI480132
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_e6d47c75_56bd_400a_8b19_5c4353592860
is: Q9BY07
boundary condition: true
name: SLC4A5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57835
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_15f18b16_10d2_4f30_8b3e_dc711f382e0e
is: SBO:0000252
is encoded by: hsa:80025
has only substance units: false
type: Species
boundary condition: true
name: PANK2
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0819
reactant: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reversible: true
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaR GQ1BALPHAtg
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
name: gq1balpha hs intracellular transport
is: SBO:0000185
type: Reaction
reversible: true

metaM gacpail hs c
is: C00092
has only substance units: false
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:61548
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
initial amount: NaN

metaM gthrd m
is: CHEBI:57925
name: glutathionate(1-)
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00125
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_51891100_c0b0_46a2_b7b2_d02841579af7
initial concentration: NaN
is encoded by: hsa:229
type: Species
constant: false
has only substance units: false
is: P05062
name: ALDOB
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM HC01408 m
name: 3-Oxohexanoyl-CoA
initial amount: NaN
is: SBO:0000247
is: CHEBI:27648
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_032f8e70_4fb6_4e09_afb8_841e87183203
is encoded by: hsa:509
initial concentration: NaN
name: ATP5C1
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q6I9V2
type: Species

metaR r0750
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#

metaR RE3567C
reactant: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000176
reversible: true
name: RE3567
kinetic law: MODEL1310110016#

metaM glyclt c
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00115

metaR URIt5le
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
name: uridine transport in via sodium symport (1:2)
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_45556b1b_4910_4155_a8b6_e5d2d3819b6c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m
is: SBO:0000252

metaR ASNNm
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
is described by: ECO:0000254
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.1
modifier: MODEL1310110016#
is: SBO:0000176
name: L-asparaginase (mitochondrial)
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_7f50aedc_b7a3_43ae_b7a7_7892724f0b76
is: SBO:0000252
has only substance units: false
type: Species
name: HKDC1
boundary condition: true
initial amount: NaN
is: B3KT70
constant: false
is encoded by: hsa:80201
initial concentration: NaN

metaM cdp m
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
constant: false
name: CDP(3-)
is: HMDB01546
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_2b51a01c_6f68_41cc_995f_7e70d4eb149d
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AD000092
is: SBO:0000252
boundary condition: true
type: Species
name: _AD000092_1_c
constant: false

metaR r2129
product: MODEL1310110016#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110016#
reversible: true

metaR G6PPer
reactant: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.9
reversible: false
name: glucose-6-phosphate phosphatase, edoplasmic reticular
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_61dfef23_427f_4b06_acbe_a68fe754d29a
is: Q4W5N8
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51166
initial concentration: NaN
name: AADAT

http://identifiers.org/biomodels.db/MODEL1310110016#_15750728_6173_42da_990f_a0e031e35ac3
initial amount: NaN
is encoded by: hsa:516
constant: false
initial concentration: NaN
is: SBO:0000252
is: P05496
has only substance units: false
name: ATP5G1
boundary condition: true
type: Species

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boundary condition: true
initial concentration: NaN
is encoded by: hsa:10606
type: Species
constant: false
is: P22234
is: SBO:0000252
has only substance units: false
name: PAICS
initial amount: NaN

metaM leuktrC4 e
constant: false
has only substance units: false
name: leukotriene C4(2-)
is: CHEBI:57973
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_aa6b5dbf_e1e7_4e6f_a3c3_dfe592df53f7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8671
initial amount: NaN
is: A5JJ20
name: SLC4A4
constant: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d0a84343_f180_471c_b8a4_32fac3fc8d33
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:9377
is: P20674
is: SBO:0000252
type: Species
name: COX5A

http://identifiers.org/biomodels.db/MODEL1310110016#_c49f86f8_3df7_4b4f_b1a6_73003ae45257
is: SBO:0000252
constant: false
name: PCBD1
boundary condition: true
initial amount: NaN
is encoded by: hsa:5092
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_d1bd8584_39cc_49e0_a7bf_6a17face17f7
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55825
type: Species
is: Q9BY49
initial concentration: NaN
is: SBO:0000252
name: PECR
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_daa598ed_3edc_4e92_b2a3_9f91ad856e5c
name: MYO5B
is encoded by: hsa:4645
boundary condition: true
constant: false
initial concentration: NaN
is: Q9H6Y6
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_7fde5a92_3c14_42d4_bcaf_586163a9b706
boundary condition: true
constant: false
name: SCD
type: Species
is encoded by: hsa:6319
initial amount: NaN
has only substance units: false
is: O00767
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_8869b535_786a_40ed_9e16_406b285c1532
type: Species
is encoded by: hsa:1582
initial amount: NaN
name: CYP8B1
has only substance units: false
is: Q9UNU6
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d63b0d37_416c_46c2_b502_32d0f52e86a9
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: _D29675_1_e
is encoded by: hsa:D29675
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_a19339ba_c31f_40ed_8328_f06c08323c5c
is encoded by: hsa:55577
name: NAGK
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9UJ70
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_1d9279cb_c7e7_482d_b238_8ca116db9c3c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:84735
is: Q96KN2
initial amount: NaN
type: Species
name: CNDP1

metaM gt1alpha hs g
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58397
type: Species
has only substance units: false
boundary condition: false
name: GT1aalpha
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_6f9825bf_8832_4cf5_93ae_47406b188308
type: Species
initial amount: NaN
boundary condition: true
name: SGPP1
has only substance units: false
is encoded by: hsa:81537
is: Q9BX95
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_8b75910c_422e_4939_9dc9_6e54b650fa9e
boundary condition: true
type: Species
is: P54687
constant: false
name: BCAT1
is encoded by: hsa:586
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR GLYCLTtp
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110016#
name: glycolate transport into peroxisome
fast: false
reactant: MODEL1310110016#
reversible: false
product: MODEL1310110016#
type: Reaction

metaR GALNTg
type: Reaction
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
name: GalNAc transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false

metaM ksi e
has only substance units: false
is: SBO:0000247
name: keratan sulfate I
is: HMDB00211
initial amount: NaN
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ba508632_9c2a_466c_a883_da5c02bdca6e
constant: false
is encoded by: hsa:80025
has only substance units: false
name: PANK2
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR ALAALACNc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: ALAALACNc
type: Reaction

metaR r0813
product: MODEL1310110016#
reversible: false
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:

metaM dag hs r
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: CHEBI:18035
name: diglyceride
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110016#
product: MODEL1310110016#
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_a0d4150e_3b1f_4494_bd16_683e79716f87
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: NDUFS6
is encoded by: hsa:4726
is: SBO:0000252
is: Q6IBC4
boundary condition: true

metaM ahcys m
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16680
type: Species
is: C00021
name: S-Adenosyl-L-homocysteine
initial amount: NaN
has only substance units: false

metaM HC01410 m
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28706
name: (2E)-Hexenoyl-CoA
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_f0665eb6_1034_41ce_a17f_92040d754b8e
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q96RV2
is: SBO:0000252
name: HAS3
constant: false
initial concentration: NaN
is encoded by: hsa:3038

metaM dtdp c
type: Species
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
is: HMDB01274
boundary condition: false
constant: false
has only substance units: false
is: C00363
name: dTDP
initial amount: NaN
is: CHEBI:58369

metaR r0752
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_c8222217_687d_4993_a571_c211d57d69ad
boundary condition: true
is: SBO:0000252
name: SLC26A6
has only substance units: false
is encoded by: hsa:65010
type: Species
initial concentration: NaN
is: Q9NQU1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_16cbba98_2137_451f_b17d_3bff41b64050
name: _NOS2A_1_c
is encoded by: hsa:NOS2A
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaM glyc m
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: Glycerol
is: CHEBI:17754
is: C00116
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110016#_2d8ecc64_f2ee_4885_8243_821e0172ab6b
is encoded by: hsa:4718
name: NDUFC2
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q549M5
initial amount: NaN
is: SBO:0000252
constant: false

metaR ILEt5m
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110016#
name: Isoleucine mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110016#_eadc191e_deb7_40fa_9d6e_514c7376cb6a
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8693
is: SBO:0000252
is: Q8N4A0
constant: false
name: GALNT4
has only substance units: false

metaM thf c
constant: false
is: HMDB01846
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
is: SBO:0000247
is: C00101
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57453

metaR RBTt
name: ribitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM biocyt c
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: C05552
is: HMDB03134
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_7d22adde_a310_4914_afbe_4be8045e80d0
is encoded by: hsa:284098
is: SBO:0000252
type: Species
is: Q7Z7B1
initial concentration: NaN
name: PIGW
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r0812
type: Reaction
kinetic law: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110016#_41ee9190_081a_40c9_9c84_0d1e28cd0577
is encoded by: hsa:2583
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q59FK0
name: B4GALNT1
initial concentration: NaN
is: SBO:0000252

metaR CMPACNAtn
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: CMP-Sia nuclear export
kinetic law: MODEL1310110016#

metaR PHETHPTOX2
reversible: false
kinetic law: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.16.1
reactant: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
fast: false
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

http://identifiers.org/biomodels.db/MODEL1310110016#_01a49010_a1a9_4e15_83dc_06d7b279de50
type: Species
is: SBO:0000252
initial amount: NaN
name: ACAT2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:39
constant: false
is: Q9BWD1

metaM dhdascb c
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58070
name: dehydroascorbide(1-)
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR CGLYt3 2
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
name: Cys-Gly transport in via proton symport
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
is: SBO:0000185
reversible: false

metaM sphs1p c
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
initial amount: NaN
constant: false
is: CHEBI:60119
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_32b4616f_2877_4070_ac43_8efd90ea6232
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P51648
has only substance units: false
constant: false
name: ALDH3A2
is encoded by: hsa:224

http://identifiers.org/biomodels.db/MODEL1310110016#_6143f485_46a2_46d7_bd8c_c0132a24c27a
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: PIPOX
is encoded by: hsa:51268
is: Q9P0Z9

metaM glcur e
boundary condition: false
initial concentration: 1.0
name: D-glucuronate
is: SBO:0000247
is: CHEBI:15748
initial amount: NaN
has only substance units: false
is: HMDB00127
constant: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110016#_b2d6a882_2a51_4341_a3d6_ca75720401c0
is: Q06055
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:517
name: ATP5G2

metaM ppcoa m
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
constant: false
is: SBO:0000247
name: Propanoyl-CoA
has only substance units: false
is: CHEBI:57392
boundary condition: false
is: C00100
initial concentration: 1.0
initial amount: NaN
type: Species

metaM andrstrn r
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false
boundary condition: false
initial amount: NaN
name: androsterone
is: SBO:0000247
is: CHEBI:16032
constant: false
is: HMDB00031
type: Species

metaR S6TASE12ly
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true
type: Reaction
fast: false
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110016#_efc26b9c_93f8_4059_b959_322294f1eb18
initial concentration: NaN
name: PIGA
constant: false
boundary condition: true
is: B3KUV7
has only substance units: false
is encoded by: hsa:5277
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_de7e4b65_c186_44a7_9d5c_99dfed7743a6
boundary condition: true
name: HSD17B10
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3028
has only substance units: false
constant: false
is: Q99714
is: SBO:0000252

metaM ksi deg2 l
has only substance units: false
name: keratan sulfate I, degradation product 2
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01356
is: CHEBI:57312
type: Species
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

metaM CE2839 e
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: http://identifiers.org/pubchem.compound/5041
type: Species
boundary condition: false
is: C01936
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 4hpro LT m
constant: false
is: CHEBI:18095
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00725
name: trans-4-hydroxy-L-proline
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_195af6e6_9bfc_4b9b_b67d_62227fec218e
initial concentration: NaN
is encoded by: hsa:4702
is: B1AM93
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: NDUFA8

http://identifiers.org/biomodels.db/MODEL1310110016#_21620a31_8e33_498e_bb8f_c8aefb87c46b
is encoded by: hsa:4719
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P28331
name: NDUFS1
has only substance units: false
constant: false

metaR r0968
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: Postulated transport reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_db1ff664_953d_40ca_b4f7_3bcf66445d88
is: SBO:0000252
name: COX2
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4513
is: Q7GXZ8

metaR H2Oter
is: SBO:0000185
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
product: MODEL1310110016#
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110016#
is described by: ECO:0000000

metaR THYOXt
product: MODEL1310110016#
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110016#
is: SBO:0000185
name: T4 transport via bicarbonate countertransport

metaR r0754
reversible: true
is: SBO:0000176
product: MODEL1310110016#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
kinetic law: MODEL1310110016#

metaR P4501B1r
is described by: ECO:0000269
name: cytochrome P450 1B1
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
reversible: false
reactant: MODEL1310110016#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_2e5f79d1_273e_4016_8a93_3ce7a45ed3ad
is: O60760
type: Species
has only substance units: false
initial concentration: NaN
name: HPGDS
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27306
constant: false
initial amount: NaN

metaR GLYCK2
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
fast: false
name: glycerate kinase
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaR RE1342C
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
name: RE1342
reactant: MODEL1310110016#
fast: false
is: SBO:0000176
product: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton

metaR RIBt
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110016#
fast: false
name: ribose transport via diffusion
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_c358f152_c259_4bee_a7e3_c96b09fc4576
is encoded by: hsa:517
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ATP5G2
type: Species
boundary condition: true
constant: false

metaR RE3421R
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110016#
name: RE3421
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176

metaR DUMPtn
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
reversible: true
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_e8feb3ea_a72b_48e9_8852_c50a7686d077
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29922
type: Species
boundary condition: true
name: NME7
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_dfc96143_9f66_498e_9278_ab0c71b5691c
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PLCB1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:23236

metaR r2043
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaR SUCCt2m
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
type: Reaction
product: MODEL1310110016#
name: succinate transport, mitochondrial
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_34e9c409_3fe0_4a82_b1c1_fd2e4c94bd67
has only substance units: false
is: Q96M32
initial amount: NaN
type: Species
constant: false
name: AK7
is encoded by: hsa:122481
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM fad e
boundary condition: false
is: HMDB01248
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
is: C00016
is: CHEBI:16238
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM ksi deg4 l
initial amount: NaN
name: keratan sulfate I, degradation product 4
type: Species
initial concentration: 1.0
constant: false
is: HMDB00868
has only substance units: false
is: SBO:0000247
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737
boundary condition: false

metaR RTOTAL3t
fast: false
name: RTOTAL3 transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_7806c769_e5ae_411b_83e9_132661948b41
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:23169
is: Q9NTN3
initial amount: NaN
constant: false
name: SLC35D1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_e916017e_1d54_4fff_b6f5_f273d463bb05
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: P02730
initial amount: NaN
type: Species
name: SLC4A1
has only substance units: false
is encoded by: hsa:6521

http://identifiers.org/biomodels.db/MODEL1310110016#_a3538189_0ccb_4f16_a68f_098ec69e03dd
initial amount: NaN
type: Species
name: LIPC
is: A6H8L5
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3990
is: SBO:0000252
boundary condition: true

metaM sphs1p e
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
type: Species

metaR r0753
fast: false
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR GLUt6
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
name: Glutamate transport via Na, H symport and K antiport
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
is described by: ECO:0000269
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
reversible: false
is: SBO:0000185

metaM glyc3p c
boundary condition: false
name: Glycerol 3-phosphate
initial amount: NaN
is: CHEBI:57597
type: Species
is: HMDB00126
is: SBO:0000247
has only substance units: false
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
constant: false

metaM 1pipdn2c x
type: Species
is: HMDB01084
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 1-piperideine-2-carboxylate
initial concentration: 1.0
is: CHEBI:16187
boundary condition: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false

metaR ST6GALNAC31
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110016#
type: Reaction
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
is: SBO:0000176
notes: GENE_ASSOCIATION: (256435.1) or (30815.1) or (81849.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#

metaM ddcacoa m
is: SBO:0000247
is: C01832
is: HMDB03571
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
initial amount: NaN
is: CHEBI:57375
has only substance units: false
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0

metaR LPS2e
kinetic law: MODEL1310110016#
reversible: false
name: lipase, extracellular
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#

metaM hom L e
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
name: L-homoserine
is: CHEBI:15699
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00719
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR RE2541E
is: SBO:0000176
product: MODEL1310110016#
name: RE2541
type: Reaction
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000000

metaR PCm
product: MODEL1310110016#
name: pyruvate carboxylase
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.4.1.1
is: SBO:0000176
kinetic law: MODEL1310110016#

metaM CE1926 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
boundary condition: false
is: CHEBI:15748
name: gama-carboxyethyl-hydroxychroman
constant: false
type: Species
is: SBO:0000247
is: HMDB00127
initial amount: NaN

metaR GALASE8ly
name: beta-galactosidase, lysosomal
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM biocyt n
boundary condition: false
type: Species
constant: false
name: Biocytin
is: HMDB03134
has only substance units: false
is: C05552
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_cffcacc5_af69_4bfa_b905_10eb35cc0627
has only substance units: false
is encoded by: hsa:522
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
type: Species
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
has part: Q6IB54

metaR GGH 6THFe
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR GLNS
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: glutamine synthetase
product: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.15

metaM triodthy e
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00265
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaM ksi deg34 l
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00812
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 34
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
type: Species
is: CHEBI:16953

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110016#_c2f55f5c_a867_4955_8b72_4397bf1d574b
is: Q8NFF2
initial amount: NaN
boundary condition: true
name: SLC24A4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:123041
constant: false

metaM Lcystin e
boundary condition: false
is: HMDB00192
has only substance units: false
name: L-cystine
initial concentration: 1.0
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaM HC02216 e
constant: false
has only substance units: false
name: prostaglandin-f2beta
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:28922

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR GGH 10FTHF5GLUe
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

http://identifiers.org/biomodels.db/MODEL1310110016#_77b9a68b_2a43_4415_93fb_30d47fa62f47
is: P31639
name: SLC5A2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6524

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM dhf e
has only substance units: false
constant: false
is: HMDB01056
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
name: dihydrofolate(2-)
initial concentration: 1.0

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_2376f6d6_9b39_4a73_a234_7a7b18a94c7a
initial concentration: NaN
name: _BE966236_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:BE966236
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ca2626eb_9498_4c8e_8d82_207de2dbdad3
has only substance units: false
is encoded by: hsa:51
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: B4DK61
constant: false
boundary condition: true
name: ACOX1

http://identifiers.org/biomodels.db/MODEL1310110016#_33940496_57c5_4de2_8a3b_6c03edfb4cfd
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _R33828_1_c
initial concentration: NaN
type: Species
is encoded by: hsa:R33828
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5b467211_fe37_4c03_90f8_fe834d6ff3bd
constant: false
is encoded by: hsa:8574
initial amount: NaN
type: Species
has only substance units: false
name: AKR7A2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O43488

metaM 34hpp c
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00707
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:36242

metaR BUP2
is described by: ECO:0000269
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.6
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
type: Reaction
is: SBO:0000176

metaR EX 6htststerone LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 6 beta hydroxy testosterone exchange
type: Reaction

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r0245
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110016#
modifier: MODEL1310110016#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110016#
type: Reaction

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR r0523
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_f1e15860_fbc7_49de_bef1_524674e469c9
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR ARGLYSex
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
name: Arginine/Lysine exchanger (Arg in)

http://identifiers.org/biomodels.db/MODEL1310110016#_f34b9da1_a131_4185_ae8c_5ebc71f68bc6
name: TMEM91
initial amount: NaN
type: Species
is: SBO:0000252
is: C9JZ62
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:641649
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e906cb0c_49f0_4bc8_9636_685fe1c83d51
is: Q01415
is encoded by: hsa:2585
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: GALK2
constant: false
initial amount: NaN
boundary condition: true

metaR TTDCAFATPc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM hom L c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
constant: false
boundary condition: false
is: CHEBI:15699
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00719

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110016#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110016#
name: sialidase, lysosomal
is described by: ECO:0000000

metaM gthrd e
is: HMDB00125
has only substance units: false
initial amount: NaN
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: glutathionate(1-)
boundary condition: false

metaR GAL3ST11
type: Reaction
product: MODEL1310110016#
name: Galactosylceramide sulfotransferase
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.11
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM idp n
is: SBO:0000247
is: HMDB03335
is: CHEBI:58280
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: IDP(3-)
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM leuktrA4 r
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: leukotriene A4(1-)
is: CHEBI:57463
is: HMDB01337
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM glyc c
initial concentration: 1.0
boundary condition: false
is: HMDB00131
initial amount: NaN
has only substance units: false
is: C00116
is: CHEBI:17754
constant: false
type: Species
is: SBO:0000247
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaM dtdp e
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58369
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01274

http://identifiers.org/biomodels.db/MODEL1310110016#_3efb9495_7439_46dd_8684_7f14d7301c51
type: Species
constant: false
name: SLC37A4
is: SBO:0000252
is: A8K0S7
is encoded by: hsa:2542
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ff41dc5d_fde5_499b_a74d_7d6bd4825b90
constant: false
name: SLC4A5
boundary condition: true
type: Species
is encoded by: hsa:57835
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM triodthy c
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine

metaR NDPK5n
kinetic law: MODEL1310110016#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110016#
is described by: ECO:0000304
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction

metaM Lcystin c
type: Species
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial concentration: 1.0
is: CHEBI:16283
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: L-cystine

metaR r0242
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6b5074f4_3da7_4262_be80_8896816a5698
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6520
boundary condition: true
constant: false
is: P08195
name: SLC3A2
initial amount: NaN
type: Species

metaR r0522
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_48c0f888_04de_4cad_b776_2bfbe601da44
name: PRDX2
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7001
is: SBO:0000252
constant: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR DUTPDPn
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: dUTP diphosphatase, nuclear
kinetic law: MODEL1310110016#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.23

metaR NADH2 u10m
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.6.99.3
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.5.3
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
name: NADH dehydrogenase, mitochondrial
is described by: ECO:0000134
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2b2d421d_767f_48ac_a8c3_fe4658370c18
name: LOXL2
initial amount: NaN
constant: false
is: Q9Y4K0
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4017
initial concentration: NaN
has only substance units: false

metaR DNDPt50m
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTTP transport via dCDP antiport
product: MODEL1310110016#
is described by: ECO:0000269
reversible: false

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
name: D-glucuronate
initial amount: NaN
constant: false
is: CHEBI:15748
has only substance units: false
is: HMDB00127
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM biocyt m
constant: false
is: C05552
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
is: HMDB03134
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_392736c2_7897_4dec_a5e6_80ce9eaa248e
constant: false
is: SBO:0000252
name: DGKZ
initial amount: NaN
is: B7Z6M3
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8525

metaM mgacpail hs r
initial concentration: 1.0
is: CHEBI:7896
type: Species
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial amount: NaN
has only substance units: false
is: C00249
boundary condition: false
is: HMDB00220
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_4750a1d3_6fd5_4717_bede_a75a98c94701
initial amount: NaN
is encoded by: hsa:1384
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: CRAT
boundary condition: true
type: Species

metaR EX fucfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leb glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_f0ff6e49_b6b0_491e_9d72_85a64a8a2f8f
name: NDUFA4
is encoded by: hsa:4697
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: O00483
initial concentration: NaN

metaM ppcoa c
has only substance units: false
is: CHEBI:57392
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
is: C00100
is: HMDB01275
constant: false
boundary condition: false
name: Propanoyl-CoA
is: SBO:0000247
initial amount: NaN

metaR 34HPPte
fast: false
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134
name: Transport of 3-(4-hydroxyphenyl)pyruvate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR MEOHt2
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
reversible: true
name: Methanol diffusion

http://identifiers.org/biomodels.db/MODEL1310110016#_acd6e5f1_d205_4ceb_9f0e_8fe7661eae4d
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM dhcholestanate c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
initial amount: NaN
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
has only substance units: false
is: CHEBI:16577

metaM ps hs e
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
type: Species
is: CHEBI:18303
initial amount: NaN
constant: false
name: phosphatidylserine
boundary condition: false
is: SBO:0000247

metaR TALA
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
modifier: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110016#_26b5d314_3e85_402c_9e52_edd6f8d3fa69
is encoded by: hsa:27068
type: Species
boundary condition: true
name: PPA2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaM glyc e
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
is: CHEBI:17754
is: C00116
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: Glycerol

metaR BACCLm
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000254

metaM gthrd c
is: SBO:0000247
is: HMDB00125
boundary condition: false
name: Reduced glutathione
is: CHEBI:57925
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
is: C00051

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
constant: false
is: HMDB00061
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58343

http://identifiers.org/biomodels.db/MODEL1310110016#_48979370_3d98_404a_8e91_b52ec2cf7e67
is: Q3I5F7
is encoded by: hsa:641372
type: Species
name: ACOT6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM met L c
constant: false
is: CHEBI:16643
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00696
initial amount: NaN
name: L-methionine
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_fc887b40_7ad9_4ab8_8767_8346a60da005
is: SBO:0000252
type: Species
name: ACP1
initial amount: NaN
is encoded by: hsa:52
boundary condition: true
has only substance units: false
is: Q59EH3
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ae08a028_93e0_4b6b_a75e_2c76c9f1849b
initial concentration: NaN
has only substance units: false
name: MGLL
boundary condition: true
initial amount: NaN
is encoded by: hsa:11343
is: SBO:0000252
constant: false
type: Species
is: B2ZGL7

http://identifiers.org/biomodels.db/MODEL1310110016#_d4c9ecdf_41e5_475c_9f10_396b66bfa8f4
name: CLYBL
is encoded by: hsa:171425
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_cc7dd064_ca67_45ac_bbde_9f25dd7b9bb0
initial amount: NaN
type: Species
initial concentration: NaN
name: _AI990637_1_x
has only substance units: false
is encoded by: hsa:AI990637
boundary condition: true
is: SBO:0000252
constant: false

metaR FATP1t
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
product: MODEL1310110016#
type: Reaction
name: fatty acid electroneutral transport
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_1050cff2_fd04_44c7_9c97_751022d7b3d5
is encoded by: hsa:9374
is: Q9UMR5
initial amount: NaN
name: PPT2
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaR HSD3B7P
reversible: false
reactant: MODEL1310110016#
is: SBO:0000176
fast: false
product: MODEL1310110016#
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
type: Reaction
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.181
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR r2048
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110016#
is: SBO:0000185

metaM HC01522 c
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: CHEBI:28508
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Gentisate aldehyde
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaR r1599
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR MALtm
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000185
name: malate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110016#_943c8354_1008_4fe6_a3ca_8e3348680014
is encoded by: hsa:2799
is: SBO:0000252
name: GNS
is: Q7Z3X3
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR ASPDt6
modifier: MODEL1310110016#
fast: false
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
name: D-aspartate transport via Na, H symport and K antiport
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: false

metaM T antigen g
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
name: T antigen (core 1)
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR LYStn
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: L-lysine transport, nuclear
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaR RE2677E
reversible: false
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
is described by: ECO:0000000
name: RE2677
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#

metaM 5aop m
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: CHEBI:17549
is: C00430
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 5-Amino-4-oxopentanoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_adb4c8d4_c860_4e84_a6b9_9a477341a040
is: Q92536
constant: false
is: SBO:0000252
name: SLC7A6
is encoded by: hsa:9057
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR RE3003M
name: RE3003
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
modifier: MODEL1310110016#
reversible: true
product: MODEL1310110016#

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
has only substance units: false
name: L-xylulose
is: CHEBI:17399
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00751
initial amount: NaN

metaR ALA DASH DTDe
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000134
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES:no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
fast: false
type: Reaction
product: MODEL1310110016#
name: exit of D-alanine from the enterocytes

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
fast: false
name: L-ascorbate transport via proton symport
type: Reaction
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_43c7fbf7_94d8_467c_a7a5_60c81235a89e
initial concentration: NaN
has part: P14415
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:482
initial amount: NaN
has only substance units: false
constant: false
name: ATP1A3:ATP1B2

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_bc35bcbc_786b_4710_8a48_256d236ce3e2
boundary condition: true
name: PPCDC
initial amount: NaN
is encoded by: hsa:60490
constant: false
is: Q96CD2
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR r2049
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false
fast: false
reactant: MODEL1310110016#

metaM ksi l
name: keratan sulfate I
constant: false
initial concentration: 1.0
is: C00095
is: CHEBI:15824
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB00660
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM met L e
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16643
is: HMDB00696
constant: false
name: L-methionine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species

metaR r2338
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110016#
type: Reaction
fast: false

metaR LYStm
kinetic law: MODEL1310110016#
type: Reaction
fast: false
name: Lysine mitochondrial transport via ornithine carrier
is: SBO:0000185
product: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000269

metaM ddcacoa x
constant: false
has only substance units: false
boundary condition: false
is: C01832
type: Species
is: CHEBI:57375
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB03571
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110016#_421b432a_a736_491e_906e_4765e0d48a8a
type: Species
boundary condition: true
initial concentration: NaN
has part: B4E3E9
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:4967
constant: false
name: DLD:DLST:OGDH:PDHX

metaR GALtly
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
fast: false
reversible: false
name: galactose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#

metaR ASNt4
reversible: false
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000185
name: L-asparagine transport in via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110016#
is described by: ECO:0000269

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110016#_fe3d64dc_3d88_4f79_a909_515b0c77f907
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:W74642
has only substance units: false
initial amount: NaN
constant: false
name: _W74642_1_c
type: Species

metaM so3 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
name: Sulfite
type: Species
is: C00094
is: CHEBI:17137
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaR 4MOPte
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_69876ed5_5cf9_4ad7_ae89_34d09ed6567d
initial amount: NaN
has only substance units: false
name: AACS
type: Species
is: Q86V21
boundary condition: true
is encoded by: hsa:65985
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR LEUKTRD4tr
is described by: ECO:0000000
name: leukotriene intracellular transport
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
reactant: MODEL1310110016#

metaR ARACHDt2
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#

metaR PRDX
reversible: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: Peroxidase (multiple substrates)
is version of: http://identifiers.org/ec-code/1.11.1.7
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
fast: false

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_79303334_19af_4d39_928c_88ce3eefd0eb
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3632
constant: false
initial amount: NaN
has only substance units: false
name: INPP5A
is: Q14642

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
has only substance units: false
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
name: ammonium
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaR r0246
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_cc454886_7d0c_49a8_9ac3_6eca6da580a7
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GMPR2
type: Species
initial amount: NaN
is encoded by: hsa:51292
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7c281775_fd9d_48d3_b70a_9d2e678b5d71
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q10471
initial concentration: NaN
is encoded by: hsa:2590
name: GALNT2

metaR r1597
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_1c4847d9_165c_48eb_a20b_7c3376c96c66
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: ACSS3
is: Q9H6R3
is: SBO:0000252
type: Species
is encoded by: hsa:79611
initial concentration: NaN

metaR r2335
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d706768c_f5d5_4ebf_8bfd_62660b17c3cc
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: ND6
is: Q7GXZ1
is encoded by: hsa:4541
type: Species

metaR NDP7er
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1f69efe3_7838_485d_9b57_3764ff67c969
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:50808
is: SBO:0000252
name: AK3
boundary condition: true
is: E7ET30
constant: false
initial amount: NaN

metaM leuktrC4 r
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: leukotriene C4(2-)
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
boundary condition: false
has only substance units: false

metaR RE2677C
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#
name: RE2677
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_1713a938_c465_440e_804a_68be1adf9b9e
is encoded by: hsa:130367
name: SGPP2
initial concentration: NaN
is: Q8IWX5
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_3dc7269e_aa60_4698_bff2_2467ec230058
is: SBO:0000252
has only substance units: false
is: Q9NRZ5
name: AGPAT4
is encoded by: hsa:56895
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_fb00a38e_e4ab_40ea_ad2f_b2742977a2be
has only substance units: false
type: Species
name: PGK1
initial amount: NaN
is encoded by: hsa:5230
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P00558

metaR CYTDK2m
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
type: Reaction
name: cytidine kinase (ATP), mitochondrial
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#

metaM CE5788 e
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: kinetensin 1-7
is: HMDB02710
is: CHEBI:27485
constant: false

metaR NAGA2ly
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
name: N-acetylgalactosaminidase, alpha-
reversible: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.49
fast: false
type: Reaction

metaM nh4 m
boundary condition: false
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
is: SBO:0000247
name: Ammonium
is: C01342
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaM fad m
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
boundary condition: false
is: CHEBI:16238
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01248

http://identifiers.org/biomodels.db/MODEL1310110016#_6fdf113c_cf4f_41e5_8b7a_46144c3a093f
name: _H45672_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:H45672
initial concentration: NaN
initial amount: NaN

metaM HC01376 m
boundary condition: false
is: SBO:0000247
has only substance units: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
constant: false
is: CHEBI:28692
type: Species

metaR GGH 10FTHF6GLUe
reactant: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_f5f05ca6_b4cd_48fe_a8f9_526f982c7833
name: SLC25A20
constant: false
initial concentration: NaN
has only substance units: false
is: O43772
initial amount: NaN
is encoded by: hsa:788
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_f4e8049c_95f5_466b_9452_cae771deef9f
name: _AL525798_1_c
is encoded by: hsa:AL525798
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM 34hpp e
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00707
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
initial amount: NaN

metaM strch1 e
is: C00020
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
is: CHEBI:456215
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00045
notes: FORMULA: C66H112O56 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaR CYTK2n
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM prostgd2 r
name: prostaglandin D2(1-)
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
is: CHEBI:57406
initial amount: NaN
has only substance units: false
is: HMDB01403
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_30d05322_5b7c_43bd_80fd_04aa50aebdd5
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:9990
type: Species
is: Q9UHW9
initial amount: NaN
name: SLC12A6
initial concentration: NaN

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction

metaR NACHEX24ly
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
reactant: MODEL1310110016#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110016#

metaR SUCOASm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reversible: true
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR PROSTGE2t2
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110016#
type: Reaction
name: prostaglandin uniport
reversible: true
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185

metaR r1656
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#

metaR r0463
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
reactant: MODEL1310110016#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction

metaM CE2870 c
type: Species
constant: false
notes: FORMULA: C15H12I2NO7S CHARGE: -1 INCHI: InChI=1/C15H13I2NO7S/c16-10-5-8(6-12(18)15(19)20)1-3-13(10)24-9-2-4-14(11(17)7-9)25-26(21,22)23/h1-5,7,12H,6,18H2,(H,19,20)(H,21,22,23)/p-1/t12-/m1/s1 EHMN_ABBREVIATION: CE2870
name: 3,3'-diiodo-L-thyronine 4'-O-sulfate
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02281
is: SBO:0000247
is: CHEBI:15374

metaM glu L r
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
has only substance units: false
name: L-glutamate(1-)
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:29985
is: HMDB00148
initial concentration: 1.0

metaR B3GNT51g
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
kinetic law: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR r1596
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_ac68d877_81b7_40e5_b79e_08a2ca11ecac
name: _AI935189_1_m
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI935189

metaR 5OXPROt
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000134
name: Transport of 5-oxoprolinate
product: MODEL1310110016#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_46c994fa_dc4c_4750_a0df_12effa6ecaf1
is: Q9H0I9
type: Species
is encoded by: hsa:84076
boundary condition: true
name: TKTL2
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM phe L c
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
constant: false
is: CHEBI:17295
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00159
boundary condition: false
initial amount: NaN
name: L-phenylalanine

metaM CE5121 m
constant: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: trans-3-decenoyl-CoA
boundary condition: false
is: CHEBI:57449

http://identifiers.org/biomodels.db/MODEL1310110016#_19928784_e866_4148_b23d_d082e259e54d
boundary condition: true
initial amount: NaN
is encoded by: hsa:522
constant: false
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has part: P56134
type: Species
is encoded by: hsa:9551
is: SBO:0000297

metaR BTNt2
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reactant: MODEL1310110016#
name: Biotin reversible transport via proton symport
fast: false
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
product: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_5b4ccf04_22cd_4e24_8f8d_526524ccd4c9
constant: false
boundary condition: true
is encoded by: hsa:33
initial concentration: NaN
is: P28330
type: Species
name: ACADL
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_a81acaa2_d0c8_47d1_807c_c4db42f9a959
is: Q9H2F3
has only substance units: false
is encoded by: hsa:80270
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: HSD3B7
type: Species

metaM xolest2 hs e
name: cholesterol ester
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17002
is: SBO:0000247

metaM galgluside hs l
is: HMDB00143
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: galactosyl glucosyl ceramide
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:12936

metaM xoldioloneh c
boundary condition: false
is: HMDB06887
initial amount: NaN
constant: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: CHEBI:2288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453

metaR COAtm
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
fast: false
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
name: CoA transporter
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_ac526c9a_2242_4b04_a15b_1eb2637e723b
initial concentration: NaN
type: Species
is: Q96QD8
is encoded by: hsa:54407
constant: false
boundary condition: true
name: SLC38A2
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR ECOAH1m
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: true
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

metaM alpa hs c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: lysophosphatidic acid
is: CHEBI:52288
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)

metaM fe3 c
is: HMDB12943
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: Fe CHARGE: 3
initial concentration: 1.0
name: Fe3+
initial amount: NaN

metaR r2333
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_325841c0_6a2c_4be3_886d_8adf8c1d2093
initial concentration: NaN
is: E9PCX6
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:440
name: ASNS
type: Species
is: SBO:0000252
constant: false

metaR ACt2r
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000000
name: acetate reversible transport via proton symport
kinetic law: MODEL1310110016#

metaR r1657
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB03411
boundary condition: false
is: CHEBI:16313
has only substance units: false
initial concentration: 1.0
constant: false

metaR r1762
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_e17eccac_c058_4471_a70d_f1a5458eecd1
type: Species
boundary condition: true
name: CHAT
initial amount: NaN
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
is: Q6LEN6
constant: false
has only substance units: false

metaR r1381
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110016#
fast: false
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_651dd374_2ebb_4dd2_b658_665e55393d63
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5279
type: Species
boundary condition: true
has only substance units: false
name: PIGC

metaM hs deg9 l
boundary condition: false
is: CHEBI:27491
initial amount: NaN
initial concentration: 1.0
is: HMDB06465
constant: false
name: heparan sulfate, degradation product 9
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C61H87N3O76S8 CHARGE: -10

http://identifiers.org/biomodels.db/MODEL1310110016#_81797a8f_c6ea_45a5_9aeb_e869fffb359c
type: Species
is encoded by: hsa:6582
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: SLC22A2
initial concentration: NaN
is: O15244

metaM ppcoa x
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
constant: false
is: HMDB01275
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Propanoyl-CoA
is: C00100

http://identifiers.org/biomodels.db/MODEL1310110016#_e45147f4_d63f_4a0f_9b8b_9a0d7dc247e8
has only substance units: false
is encoded by: hsa:1103
is: D3DX95
boundary condition: true
constant: false
name: CHAT
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_cce2b6dd_91e0_4011_9574_1742d5a05a3d
is encoded by: hsa:115019
is: B3KXK1
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC26A9
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_242004c8_ac66_4ce0_b1b9_7cb056779e83
is encoded by: hsa:376497
has only substance units: false
is: Q6PCB7
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC27A1

http://identifiers.org/biomodels.db/MODEL1310110016#_0d464014_cde6_41f9_a6cd_090d73ac48d0
initial amount: NaN
type: Species
initial concentration: NaN
name: _AI435857_1_x
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI435857

metaR r1301
is: SBO:0000185
product: MODEL1310110016#
reversible: false
fast: false
name: Vesicular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#

metaR r2332
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1594
reactant: MODEL1310110016#
fast: false
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_e9319e67_43ab_4745_9914_fffd4f09876f
name: NDUFB3
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: Q6IB80
initial concentration: NaN
is encoded by: hsa:4709
is: SBO:0000252
has only substance units: false

metaM 3uib c
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:1670
is: HMDB02031
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
name: 3-Ureidoisobutyrate

http://identifiers.org/biomodels.db/MODEL1310110016#_4a06a25f_0a8c_467a_b07a_cd0ff9321d3d
has part: O75947
has part: P18859
boundary condition: true
has only substance units: false
is encoded by: hsa:10476
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
has part: P24539
initial concentration: NaN
type: Species
is encoded by: hsa:515
is: SBO:0000297
is encoded by: hsa:518
constant: false

metaR r1380
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110016#

metaR S6TASE11ly
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
fast: false

metaM dtdp n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
constant: false
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR r1493
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
reactant: MODEL1310110016#
is: SBO:0000185
reversible: false
fast: false
name: Utilized transport
is described by: ECO:0000000

metaR r1654
type: Reaction
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_02d0d916_8c38_4f4c_a8b1_0dfc7808a34b
name: PTGIS
is: Q16647
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5740
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_c5ec4ec6_8029_46a7_ace6_ba142f8da7bb
is: SBO:0000252
is: A5PKZ1
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:11227
boundary condition: true
name: GALNT5

metaR r0517
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_a5c5e3d9_bc91_4615_a814_7e3b0d9acd4f
is: B7Z5G2
type: Species
is encoded by: hsa:2629
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: GBA
boundary condition: true

metaM xolest2 hs c
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
name: cholesterol ester
initial amount: NaN
constant: false
is: CHEBI:17002

metaR P4508B11r
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: sterol 12-alpha-hydroxylase
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
product: MODEL1310110016#
fast: false
is described by: ECO:0000269

metaR r0683
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
reversible: false
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

metaM dtdp m
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
constant: false
initial amount: NaN
is: C00363
initial concentration: 1.0
has only substance units: false
is: CHEBI:58369
is: SBO:0000247
is: HMDB01274
type: Species

metaM ksii core2 deg7 l
is: HMDB00812
is: CHEBI:16953
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 7
notes: FORMULA: C44H73N4O30X CHARGE: 0
is: SBO:0000247
constant: false

metaM thf m
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: C00101
constant: false
is: HMDB01846
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate

metaR SCPx
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
name: peroxisomal thiolase 2
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM pro D e
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16313
type: Species
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
is: HMDB03411
initial concentration: 1.0
initial amount: NaN

metaR r1593
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r1302
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Vesicular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#

metaM fe3 e
constant: false
type: Species
is: CHEBI:29034
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0
is: HMDB12943
name: Fe3+

metaR r2331
is: SBO:0000185
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1020
reversible: true
product: MODEL1310110016#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
reversible: true

metaR r1492
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false
fast: false
name: Utilized transport
reactant: MODEL1310110016#

metaM CE4872 c
is: CHEBI:15748
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_85890a97_5a79_4ceb_8e14_c0ee33143143
initial concentration: NaN
name: CDO1
is: Q16878
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1036
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_decb96ca_5373_4692_bcf3_692f7ba2eaac
is encoded by: hsa:2098
name: ESD
is: P10768
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaM ksii core4 deg4 l
initial amount: NaN
is: HMDB00812
is: CHEBI:16953
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: keratan sulfate II (core 4-linked), degradation product 4

metaR DNDPt28m
reversible: false
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110016#
name: dCDP transport via dGDP antiport
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_d8da14e8_3492_4f97_a1fd_e9d300754a5a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:196951
name: C15orf33
type: Species
is: Q96M60

metaM glygn2 e
is: SBO:0000247
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
initial concentration: 1.0
is: CHEBI:4167
initial amount: NaN
type: Species
is: HMDB00122
has only substance units: false
boundary condition: false
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_4e96f1ff_d5ab_423d_9ee6_b49a84cb087c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: O95340
name: PAPSS2
is encoded by: hsa:9060
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_4ba86776_557e_4b84_bb64_2ab3b22c07a7
is: P22413
has only substance units: false
initial amount: NaN
is encoded by: hsa:5167
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ENPP1
boundary condition: true

metaR LEUKTRF4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: leukotriene F4 transport
reactant: MODEL1310110016#

metaM CE2838 e
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
boundary condition: false
type: Species
name: maltononaose
is: C01936

metaR GPIDA2er
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
type: Reaction
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
is: SBO:0000176

metaM cdp c
initial concentration: 1.0
name: CDP
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58069
is: HMDB01546
boundary condition: false
is: C00112
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

http://identifiers.org/biomodels.db/MODEL1310110016#_6361a152_5eb8_4de2_b3d3_27474dac9643
name: UAP1L1
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q3KQV9
is encoded by: hsa:91373
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2330
reversible: true
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM ps hs c
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:18303
name: ps_hs[c]
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a077c263_2852_43a7_a162_bdc502de7b96
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23305
constant: false
name: ACSL6
is: B2RB13
initial concentration: NaN
type: Species

metaR ACt2m
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: acetate mitochondrial transport via proton symport
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r1592
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#

metaR RE1520M
fast: false
reversible: true
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
name: RE1520
reactant: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM ksi deg23 l
name: keratan sulfate I, degradation product 23
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_f009e244_86c2_4f5d_a5b5_fc6a97b77207
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2745
constant: false
name: GLRX
is: P35754
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bd9a9980_7839_4605_9fb9_74e00c31b5a0
is encoded by: hsa:506
type: Species
initial amount: NaN
initial concentration: NaN
name: ATP5B
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P06576

http://identifiers.org/biomodels.db/MODEL1310110016#_cc82ff69_ded5_49fe_9dbb_51ad61dd218b
is: E9PAY8
name: PPAP2C
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8612
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
initial amount: NaN
is: HMDB06487
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_97a6b727_53f6_4385_976c_ee4271bcc9f2
has only substance units: false
initial amount: NaN
is: Q9ULC5
is encoded by: hsa:51703
name: ACSL5
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaM ditp n
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:61382
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false
initial amount: NaN
name: dITP(4-)
is: HMDB03537

http://identifiers.org/biomodels.db/MODEL1310110016#_0c698f78_a619_4e41_84e3_d4f37da69392
name: INPP4A
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3631
constant: false
has only substance units: false
initial concentration: NaN

metaM glu L m
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
is: CHEBI:29985
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-glutamate(1-)

metaM uri e
initial amount: NaN
has only substance units: false
name: Uridine
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
is: CHEBI:16704
is: HMDB00296
is: C00299
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR BHBtm
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_67efc5e5_0064_424c_a8a1_8f68a7ec0562
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PLD1
is: Q59EA4
boundary condition: true
is encoded by: hsa:5337

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR RE1530M
is version of: http://identifiers.org/ec-code/2.7.1.21
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
name: RE1530
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaR r2120
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110016#

metaR NACHEX26ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000000

metaM leuktrA4 c
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57463
boundary condition: false
is: HMDB01337
is: SBO:0000247
has only substance units: false

metaR r1591
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction

metaM galgluside hs g
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00295
type: Species
constant: false
is: SBO:0000247
name: galactosyl glucosyl ceramide
is: C00015
is: CHEBI:58223
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial amount: NaN

metaM m2mn l
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: HMDB06537
constant: false
has only substance units: false
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110016#_5b3cb6a3_8481_4561_8cfc_b4b75c85c0e0
is encoded by: hsa:4831
initial concentration: NaN
constant: false
name: NME1:NME2
is encoded by: hsa:4830
has part: P15531
type: Species
has part: P22392
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000297

metaR H2Otly
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: H2O transport, lysosomal

metaR HCO3 CLt
modifier: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: true
name: bicarbonate transport (Cl-/HCO3- exchange)
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
reactant: MODEL1310110016#
type: Reaction

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.7
product: MODEL1310110016#

metaR COAtp
kinetic law: MODEL1310110016#
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_78bc63f0_6b54_4b57_8356_cbe0f06e34d4
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:483
name: ATP1B3
boundary condition: true
is: P54709

http://identifiers.org/biomodels.db/MODEL1310110016#_17d71335_c4f0_49e4_8f12_45ffb20bcd97
has only substance units: false
constant: false
name: COX5B
is: Q53YB7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1329
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_aa4bdbd5_cb87_4354_9c99_ef7b7d93b09b
is: SBO:0000252
name: SLC1A1
is encoded by: hsa:6505
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P43005
constant: false

metaR r0680
is version of: http://identifiers.org/ec-code/2.3.1.137
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000000

metaR S6TASE13ly
reversible: true
type: Reaction
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176

metaR 2HCO3 NAt
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaM 2mop c
is: HMDB01172
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false
is: CHEBI:57700
constant: false
name: 2-methyl-3-oxopropanoate
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r1590
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_cb12ae69_23c4_4def_a389_5791aceb0598
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r2402
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110016#
fast: false
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR UMPK3n
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#

metaM so4 m
has only substance units: false
boundary condition: false
constant: false
name: sulfate
initial concentration: 1.0
type: Species
is: CHEBI:16189
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
initial amount: NaN

metaR PPCDC
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: false
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110016#

metaR DESAT20 1
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110016#

metaR r1418
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110016#
reversible: true
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_19ad12a5_89cc_42a1_8b63_2c0c60a1d672
is: B4DKS0
is encoded by: hsa:6566
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: SLC16A1
boundary condition: true
type: Species

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#

metaM uri c
name: Uridine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
constant: false
is: CHEBI:16704
is: C00299
type: Species
is: HMDB00296
initial concentration: 1.0
has only substance units: false

metaR KCCt
fast: false
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: K+-Cl- cotransport
reversible: true
modifier: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000185

metaR NACHEX15ly
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_7e6088c7_aa8f_475b_9877_38f92a54e45e
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PLCL1
initial concentration: NaN
constant: false
is: Q15111
is encoded by: hsa:5334
type: Species

metaM leuktrA4 e
constant: false
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)
type: Species
is: CHEBI:57463
initial concentration: 1.0
is: HMDB01337
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM pac c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
is: CHEBI:18401
has only substance units: false
type: Species
is: HMDB00209
initial amount: NaN
name: phenylacetate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_86e5e1a8_a63c_49a6_a3be_522130160479
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:131
type: Species
is: P40394
name: ADH7

metaR BIOCYTtn
reversible: true
product: MODEL1310110016#
fast: false
name: biocytin transport, nuclear
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110016#

metaR r0464
kinetic law: MODEL1310110016#
fast: false
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000

metaM itacon m
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
name: itaconate(2-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02092
is: CHEBI:17240

metaM so4 l
initial amount: NaN
is: CHEBI:16189
has only substance units: false
constant: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01448

metaR COAtn
reactant: MODEL1310110016#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
name: coenzyme A transport, nuclear
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaR UMPKn
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
name: UMP kinase, nuclear
product: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_992c9b21_b751_45fe_a713_b9318fac6b79
type: Species
is: Q96FL9
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:79623
name: GALNT14
initial amount: NaN
initial concentration: NaN

metaR HSD3A1r
is described by: ECO:0000269
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR r1659
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110016#

metaM HC02216 c
type: Species
is: CHEBI:28922
name: prostaglandin-f2beta
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_91cadf42_fff8_4727_9969_30a2814569f5
initial concentration: NaN
name: HK2
is: SBO:0000252
initial amount: NaN
is: P52789
is encoded by: hsa:3099
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8ea6bcbb_7e76_4255_8f42_abd78402b639
is: P49189
name: ALDH9A1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:223
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r0514
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110016#

metaR 3HKYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
kinetic law: MODEL1310110016#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000304
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_21e3d440_0f4d_4265_8501_367bfda64406
is encoded by: hsa:7371
has only substance units: false
is: Q9BZX2
initial concentration: NaN
boundary condition: true
type: Species
name: UCK2
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR DNDPt8m
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
name: dADP transport via dUDP antiport
modifier: MODEL1310110016#
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110016#_22110bbd_3f27_4db9_8bd1_d0d2b38a23e7
is: O95498
is encoded by: hsa:8875
name: VNN2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false

metaM kynate c
is: SBO:0000247
type: Species
name: kynurenate
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58454
initial concentration: 1.0
is: HMDB00715
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaM air c
is: HMDB01235
is: CHEBI:58592
is: SBO:0000247
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
boundary condition: false
is: C03373
type: Species
has only substance units: false

metaM nh4 x
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
name: Ammonium
is: CHEBI:28938
constant: false
initial concentration: 1.0
type: Species
is: C01342

metaM 2mop m
is: HMDB01172
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 2-methyl-3-oxopropanoate
boundary condition: false
constant: false
initial concentration: 1.0

metaM acetol c
is: HMDB06961
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
boundary condition: false
is: CHEBI:27957
initial concentration: 1.0
is: SBO:0000247
constant: false
name: hydroxyacetone
has only substance units: false
initial amount: NaN
type: Species

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_93e952c2_7238_42a8_b7e5_d164c795ce4d
initial amount: NaN
type: Species
name: _22305_2_c
initial concentration: NaN
is encoded by: hsa:22305
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR r0743
product: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110016#
fast: false

metaR GLYtp
reactant: MODEL1310110016#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110016#
name: glycine passive transport to peroxisome
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

metaM HC02213 c
name: prostaglandin-e3
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
is: CHEBI:28031
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_81f399f0_08c5_4705_948f_fe58547cd451
is encoded by: hsa:8527
name: DGKD
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR NADtx
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
fast: false
name: transport of NAD into peroxisome
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is described by: ECO:0000269
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
is: SBO:0000176
name: valine transaminase, mitochondiral
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM HC01610 e
is: CHEBI:28607
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
name: CoproporphyrinogenI
initial amount: NaN
has only substance units: false

metaR r2123
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_64a3234e_afa1_41f3_bdde_fc841bad5131
constant: false
is encoded by: hsa:80347
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q13057
has only substance units: false
name: COASY
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_7620ffb3_e87c_45d4_92b1_c926eb1bcc5f
is: P40926
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:4191
is: SBO:0000252
initial amount: NaN
type: Species
name: MDH2

metaM ga1 hs g
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI: InChI=1S/C19H24O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h10-13,20,24H,1,3-8H2,2H3,(H,21,22)/p-1/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
is: CHEBI:58524
constant: false
name: gibberellin A1(1-)
initial amount: NaN
initial concentration: 1.0

metaR SRTNt6 2 r
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110016#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR RE1233C
is described by: ECO:0000000
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
fast: false
name: RE1233
kinetic law: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#

metaM ddcacoa c
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
initial amount: NaN
is: CHEBI:57375
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03571
is: SBO:0000247
boundary condition: false
is: C01832

metaM xoldiolone c
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: SBO:0000247
is: CHEBI:28477
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB02197
initial concentration: 1.0

metaR DOPAt4 2 r
type: Reaction
reversible: true
reactant: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaR r0407
is: SBO:0000176
reversible: true
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reactant: MODEL1310110016#

metaR DNDPt34m
name: dGDP transport via dTDP antiport
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM inost c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:17268
constant: false
has only substance units: false
name: myo-inositol
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0

metaM dag hs e
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18035
is: SBO:0000247
name: diglyceride
initial amount: NaN
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaR PCHOLPg hs
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reactant: MODEL1310110016#
name: choline phosphatase
reversible: false
fast: false
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110016#_9d861513_c2e3_45d5_ae24_85ad2327b91a
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AW277253_1_c
constant: false
is encoded by: hsa:AW277253

metaR r0744
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
product: MODEL1310110016#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR A MANASEly
is: SBO:0000176
product: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
modifier: MODEL1310110016#
name: alpha-mannosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_5157fd17_7afe_4a11_9421_64be3a123de8
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: O95436
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10568
name: SLC34A2
type: Species

metaM galgluside hs c
type: Species
constant: false
has only substance units: false
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
is: HMDB06535
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_2372ade6_2ec4_4417_a023_6b86440d4679
type: Species
boundary condition: true
name: SLC26A8
is encoded by: hsa:116369
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q96RN1
initial amount: NaN

metaR r2124
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM 3hmbcoa m
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: CHEBI:57312
is: HMDB01356
has only substance units: false

metaR SERGLYexR
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000304
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange

metaM ocdca c
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:25629
initial concentration: 1.0
boundary condition: false
constant: false
name: stearate

metaR NACHEX18ly
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_d43581af_f153_4403_ba72_1a665ec47558
constant: false
is: SBO:0000252
name: NT5C3
is encoded by: hsa:51251
has only substance units: false
type: Species
is: Q9H0P0
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM acgam r
type: Species
constant: false
name: N-acetyl-D-glucosamine
initial amount: NaN
is: CHEBI:17411
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
is: HMDB00215
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_a6f861f3_62ea_40b7_b89c_420d258a2015
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O00400
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9197
boundary condition: true
name: SLC33A1

metaR MTHGXLt
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Methylglyoxal transport (cytosol to extracellular)
reversible: false
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110016#_1bec25ca_0c4c_43f1_bef6_e4fd5f730a4c
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AI378339_1_m
is encoded by: hsa:AI378339

metaM HC02213 e
name: prostaglandin-e3
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:28031
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
type: Species

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_2446d136_5944_49d7_8c14_0c098353b588
type: Species
constant: false
is: Q9BR01
is encoded by: hsa:25830
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SULT4A1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_6e62c1a3_f44c_467e_913c_ed4251dc2635
initial amount: NaN
has only substance units: false
type: Species
name: LDHAL6B
is encoded by: hsa:92483
constant: false
boundary condition: true
is: Q9BYZ2
is: SBO:0000252
initial concentration: NaN

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000269
fast: false

metaM HC01434 m
is: SBO:0000247
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
name: oxalatosuccinate(3-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58931
constant: false

metaR PI34P5K
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110016#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is: SBO:0000176
kinetic law: MODEL1310110016#

metaM sphs1p r
is: CHEBI:60119
has only substance units: false
is: HMDB00277
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial amount: NaN
type: Species

metaR r0130
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_a1819fd5_a994_4ca7_ad53_41c6b05a8e66
is: SBO:0000252
initial amount: NaN
is: P22392
constant: false
type: Species
has only substance units: false
boundary condition: true
name: NME2
initial concentration: NaN
is encoded by: hsa:4831

metaR DM dctp n
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dctp(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_2eb20db2_e532_4c84_9e54_650bc62eb4ea
name: SLC25A21
is: G3V4L5
boundary condition: true
is encoded by: hsa:89874
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2bb85886_ac2e_49bc_b5f4_f1cb153921bb
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3283
initial amount: NaN
name: HSD3B1
is: P14060
has only substance units: false
boundary condition: true

metaM hs deg24 l
initial concentration: 1.0
is: CHEBI:16126
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C31H50NO26 CHARGE: -1
boundary condition: false
has only substance units: false
name: GlcNAc-GlcA-(Gal)2-Xyl
constant: false

metaM hs l
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28815
type: Species
has only substance units: false
name: heparan sulfate, free chain

metaR r2121
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM cdp e
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
initial amount: NaN
is: HMDB01546
boundary condition: false
is: CHEBI:58069
name: CDP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_69229430_6d46_4563_b916_8e25541f4929
is: SBO:0000252
is encoded by: hsa:BC005314
name: _BC005314_1_x
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR HS1ly
reversible: false
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction

metaM dag hs c
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18035
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247

metaM Rtotal c
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01448
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:16189
boundary condition: false
type: Species
name: R total
has only substance units: false

metaR COAtr
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
product: MODEL1310110016#
name: COA transporter, endoplasmic reticulum
fast: false
reversible: true
type: Reaction

metaR GTHRDtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
name: glutathione transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110016#_be69237f_5eb2_4dcb_a699_f31d9a7ceb7b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q99519
is encoded by: hsa:4758
name: NEU1
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaM thf e
is: CHEBI:57453
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
constant: false

metaM pyam5p c
constant: false
initial amount: NaN
boundary condition: false
name: Pyridoxamine 5'-phosphate
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
is: CHEBI:58451
initial concentration: 1.0
is: SBO:0000247
is: C00647
type: Species
has only substance units: false
is: HMDB01555

http://identifiers.org/biomodels.db/MODEL1310110016#_56f8aff1_78cc_4802_bb4b_23c025cadbfc
constant: false
is: SBO:0000252
is: Q8TCG5
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:126129
initial concentration: NaN
has only substance units: false
name: CPT1C

metaR NDPK8
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Nucleoside-diphosphate kinase (ATP:dADP)

http://identifiers.org/biomodels.db/MODEL1310110016#_c628eb8a_5e04_469a_93d4_4ae5416742b0
name: ACAA1
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q96CA6
constant: false
is encoded by: hsa:30
type: Species

metaR UGALNACtg
reactant: MODEL1310110016#
is described by: ECO:0000269
name: UDP-GalNAc Golgi transport via CMP antiport
type: Reaction
fast: false
reversible: true
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6cbd328c_cecf_45b6_aad6_372b2747f5a3
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9UN42
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:23439
name: ATP1B4

metaR RE1530C
name: RE1530
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_ad7c8e18_a626_4978_8c3a_1f684af96b67
is: SBO:0000252
boundary condition: true
is encoded by: hsa:953
type: Species
initial amount: NaN
name: ENTPD1
is: Q86VV3
initial concentration: NaN
constant: false
has only substance units: false

metaR r2122
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110016#

metaR r0355
reactant: MODEL1310110016#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110016#
reversible: false
is described by: ECO:0000000

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_db6442ea_7748_4d7d_bd0c_1aefb4bb3fc7
initial amount: NaN
is: SBO:0000252
is: Q6IBB5
boundary condition: true
has only substance units: false
initial concentration: NaN
name: NDUFA1
constant: false
type: Species
is encoded by: hsa:4694

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR PAFt
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
fast: false
is described by: ECO:0000000
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110016#

metaR BALAPAT1tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_efc91006_decb_4ae4_85ce_d068c469cf1d
initial amount: NaN
is: P47712
initial concentration: NaN
is: SBO:0000252
name: PLA2G4A
is encoded by: hsa:5321
boundary condition: true
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d1339cff_c061_4fd0_8f1a_438c0ce172e3
has only substance units: false
is: E7EUT4
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2597
name: GAPDH

metaR DIDPtn
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: dIDP nuclear transport
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR DNDPt12m
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via ADP antiport
kinetic law: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_152583ab_4107_43be_b186_701b04bae5c2
is: Q03393
initial amount: NaN
is encoded by: hsa:5805
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PTS
boundary condition: true

metaR r0354
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
reactant: MODEL1310110016#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false

metaR RE1517M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
product: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1517
reactant: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

metaM 34dhoxmand m
is: CHEBI:27637
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
name: 3,4-Dihydroxymandelate

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
type: Reaction

metaM acgam l
has only substance units: false
constant: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
boundary condition: false
is: SBO:0000247
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
initial amount: NaN
is: CHEBI:17411

metaR r2127
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0747
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reversible: true
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110016#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR r1303
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#

metaR APAT2rm
product: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)

http://identifiers.org/biomodels.db/MODEL1310110016#_ad3be7df_5c71_49ff_8f46_3727c1dc00e0
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P00441
initial concentration: NaN
boundary condition: true
name: SOD1
is encoded by: hsa:6647

metaM idp e
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
is: SBO:0000247
is: HMDB03335
boundary condition: false
initial amount: NaN
type: Species

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR r0688
product: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110016#_ff582e96_3aef_43de_8fa1_f51f9cfab2cf
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_c

metaM Rtotal e
initial amount: NaN
name: R total
is: C00255
notes: FORMULA: CO2FULLR CHARGE: -1
is: HMDB00244
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:3554
is: SBO:0000247
type: Species

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_ea9cd2b9_70d0_4eed_af94_92db735ed1ac
initial concentration: NaN
has only substance units: false
is: Q99798
is: SBO:0000252
name: ACO2
boundary condition: true
is encoded by: hsa:50
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9d751808_fd83_45e2_a695_3cc9bc12e16b
boundary condition: true
name: _AI640625_1_c
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI640625
initial concentration: NaN
type: Species

metaR r1653
fast: false
kinetic law: MODEL1310110016#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#

metaM thymd c
is: HMDB00273
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: Thymidine
is: CHEBI:17748
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_2f28aa33_fd3d_4223_9b68_b76a772d0213
name: CMA1
is encoded by: hsa:1215
has only substance units: false
is: Q4FEB3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_9d4f40ee_4346_4b40_a367_0479bee5b9f9
initial concentration: NaN
name: _AA977580_1_c
has only substance units: false
is encoded by: hsa:AA977580
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR LINKDEG1ly
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110016#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
type: Reaction

metaR r2128
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR r1304
kinetic law: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
name: Vesicular transport

metaM g6p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
is: CHEBI:61548
is: C00092
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01401
name: D-Glucose 6-phosphate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d449eca2_ba96_4fda_8955_89e3e03dffa3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DYLX2
type: Species
constant: false
is: F5H123
boundary condition: true
initial amount: NaN
is encoded by: hsa:9856

http://identifiers.org/biomodels.db/MODEL1310110016#_4fc7169f_598f_4a59_89e3_14f21f57933b
initial amount: NaN
boundary condition: true
is: P11310
is: SBO:0000252
name: ACADM
constant: false
is encoded by: hsa:34
type: Species
initial concentration: NaN
has only substance units: false

metaR ADNt
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
name: adenosine facilated transport in cytosol
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction

metaM pcrn x
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
is: HMDB00824
constant: false
name: propionyl-carnitine
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247

metaR CREATtmdiffir
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:14977199,PMID:3896131 NOTES:SAB
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: Creatine transport to/from mitochondria via diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_663e114d_8942_4ba7_8573_407b5e8e951e
name: ME3
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:10873
initial concentration: NaN
is: Q6TCH8
has only substance units: false
constant: false

metaR r0408
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR r1650
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#

metaM gthrd r
name: glutathionate(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
is: CHEBI:57925
constant: false
boundary condition: false
type: Species
is: HMDB00125
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_556e8718_a1e2_46ad_918b_de04fc28bdf3
type: Species
is: Q14032
constant: false
has only substance units: false
is encoded by: hsa:570
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: BAAT

metaM hs deg3 l
boundary condition: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
is: SBO:0000247
name: heparan sulfate, degradation product 3
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8ea7ee70_fa5d_4ada_838a_93ee97ebc23b
is encoded by: hsa:5298
name: PI4KB
is: Q9UBF8
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR r1384
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
is: SBO:0000176

metaM e4p c
type: Species
is: C00279
constant: false
has only substance units: false
name: D-Erythrose 4-phosphate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16897
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: HMDB01321

metaR DOLPMT4 Uer
fast: false
reversible: false
product: MODEL1310110016#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_10d0c03a_fb7c_4556_9854_8a5b04e270c9
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q16836
type: Species
name: HADH
boundary condition: true
is encoded by: hsa:3033
initial concentration: NaN

metaR r0033
reversible: false
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110016#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24

http://identifiers.org/biomodels.db/MODEL1310110016#_b6a69799_dbd6_4191_b7e8_fc3548c86aa6
name: NDUFA8
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: B1AM93
is encoded by: hsa:4702
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r2125
is: SBO:0000185
kinetic law: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
fast: false

metaR PYDXPP
reversible: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: Pyridoxal 5-phosphate phosphatase
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.3
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:

metaM idp c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
constant: false
is: HMDB03335
is: CHEBI:58280
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_313293fe_0427_4918_ae8f_bf288bf41f2c
is: SBO:0000252
constant: false
is: P43353
is encoded by: hsa:221
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ALDH3B1
initial amount: NaN
type: Species

metaR r0686
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000

metaR DNDPt61m
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: dGTP transport via dTDP antiport
reactant: MODEL1310110016#

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1bf5e63d_d903_46b1_8dd2_31b159482955
constant: false
initial concentration: NaN
name: EARS2
has only substance units: false
initial amount: NaN
is: Q5JPH6
is: SBO:0000252
is encoded by: hsa:124454
type: Species
boundary condition: true

metaR GLYtm
fast: false
reactant: MODEL1310110016#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
product: MODEL1310110016#
is: SBO:0000185

metaR FAEL183
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
is: SBO:0000176
modifier: MODEL1310110016#
name: fatty-acyl-CoA elongation (n-C18:3CoA)

http://identifiers.org/biomodels.db/MODEL1310110016#_38ce2f43_748e_4e67_a3ab_246d33fa9b2b
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: P00918
is encoded by: hsa:760
has only substance units: false
constant: false
is: SBO:0000252
name: CA2

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
name: retinol dehydrogenase (9-cis,NADPH)
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105

metaM inost e
constant: false
initial concentration: 1.0
is: CHEBI:17268
is: SBO:0000247
boundary condition: false
name: myo-inositol
has only substance units: false
is: HMDB00211
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137

http://identifiers.org/biomodels.db/MODEL1310110016#_ac518490_1987_4a66_b9b3_f2d8c8fdcbf6
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: Q9Y217
type: Species
is encoded by: hsa:9107
name: MTMR6
initial concentration: NaN

metaM HC02175 c
constant: false
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: caprate
is: CHEBI:27689

metaM ditp c
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
initial amount: NaN
name: dITP(4-)
is: CHEBI:61382
is: HMDB03537
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM tetde5coa x
name: 5-tetradecenoylcoa
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: HMDB04257
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false

metaM thymd e
is: HMDB00273
initial concentration: 1.0
constant: false
has only substance units: false
is: C00214
is: CHEBI:17748
name: Thymidine
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_6a598f2a_7ee2_47a8_a35f_b22c65be5b5f
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1178
is: C5HZ13
initial amount: NaN
name: CLC

metaR r1651
is: SBO:0000185
kinetic law: MODEL1310110016#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction

metaR CMPACNAtg
modifier: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
product: MODEL1310110016#
is described by: ECO:0000269
reversible: true
name: CMP-Sia Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_be1477e6_04cf_427a_a059_a80bfe854baa
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AI926493
is: SBO:0000252
name: _AI926493_1_c
initial concentration: NaN
type: Species

metaR 1PPDCRp
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110016#_2d09754d_47c6_4428_a83a_48bac3309a28
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: TXNRD1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:7296

metaR r2126
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#

metaM ocde9ecoa x
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: 9-octadecenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false

metaM HC00319 m
initial amount: NaN
boundary condition: false
is: CHEBI:30794
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
name: Malonate
has only substance units: false
initial concentration: 1.0
type: Species

metaR r2324
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR GGH 6DHFe
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_58d6e5f8_8d0f_4e0a_96d5_a3f8e7453296
is: SBO:0000252
name: AGPAT5
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55326
constant: false
is: Q9NUQ2

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
product: MODEL1310110016#
is: SBO:0000176
fast: false

metaM gmp c
is: SBO:0000247
initial amount: NaN
is: HMDB01397
type: Species
boundary condition: false
constant: false
name: GMP
is: C00144
has only substance units: false
is: CHEBI:58115
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaM nrpphr e
type: Species
is: SBO:0000247
is: HMDB00216
initial concentration: 1.0
is: CHEBI:33569
boundary condition: false
has only substance units: false
name: Norepinephrine
constant: false
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaM pchol hs g
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false
type: Species
name: Phosphatidylcholine
initial amount: NaN
is: CHEBI:16110
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM glcur l
is: SBO:0000247
is: HMDB00127
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: D-glucuronate
is: CHEBI:15748
constant: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_40dec44a_ac15_4f55_8c7c_ef79d7fa5692
is encoded by: hsa:AL048840
has only substance units: false
name: _AL048840_1_c
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110016#
fast: false
name: PTPATe
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true

metaM ins e
initial concentration: 1.0
name: Inosine
boundary condition: false
type: Species
is: HMDB00195
has only substance units: false
initial amount: NaN
is: CHEBI:17596
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
is: C00294

metaR GDPFUCtg
name: GDPFuc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction

metaM sarcs m
initial amount: NaN
name: Sarcosine
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial concentration: 1.0
constant: false
has only substance units: false
is: C00213
type: Species
is: SBO:0000247
is: CHEBI:15611
boundary condition: false
is: HMDB00271

http://identifiers.org/biomodels.db/MODEL1310110016#_87ed2e05_392e_4d22_94d3_9bc9835e6e3f
initial concentration: NaN
boundary condition: true
is: Q02218
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: OGDH
is encoded by: hsa:4967
type: Species

metaM ncam e
is: CHEBI:0
is: C00153
boundary condition: false
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01406
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_51f0be54_10cc_43e8_8015_b4e56e040295
name: ALDH1A1
initial amount: NaN
is encoded by: hsa:216
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: P00352
initial concentration: NaN

metaM ptth m
is: HMDB03426
is: CHEBI:16753
constant: false
boundary condition: false
type: Species
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_c5ada758_ebd2_47ff_935d_e13b31a880e2
boundary condition: true
is: A8K460
initial amount: NaN
name: PLA2G6
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:8398

metaR r2323
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM gdpfuc c
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01095
is: CHEBI:57984
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_2e4e3831_1e72_4c08_966a_ad9b2addb049
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2222
has only substance units: false
is: P37268
is: SBO:0000252
type: Species
name: FDFT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_c2c6b0e9_7bdb_4764_b284_197ebcce9ecf
is: A8K7W0
type: Species
initial concentration: NaN
is encoded by: hsa:8875
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: VNN2
is: SBO:0000252

metaM Rtotalcoa c
is: CHEBI:16189
boundary condition: false
has only substance units: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB01448
constant: false
name: R total Coenzyme A
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_bdd17a22_30cb_4386_a7f0_39806502ea84
is encoded by: hsa:349565
has only substance units: false
constant: false
is: Q96T66
is: SBO:0000252
name: NMNAT3
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaM chol g
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
is: HMDB00097
boundary condition: false

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110016#_67c028d5_4573_454f_af69_770516cf7bef
name: INPPL1
is encoded by: hsa:3636
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O15357
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_b6ca9ed4_438f_426a_bd14_7dd9db0c9679
is: Q9NX14
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: NDUFB11
constant: false
initial concentration: NaN
is encoded by: hsa:54539

metaR ATPS4m
is: SBO:0000185
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.14
is version of: http://identifiers.org/ec-code/3.6.4.6
name: ATP synthase (four protons for one ATP)
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.3.14
is described by: ECO:0000134
reversible: false
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…

metaR r2080
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000185
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_4a82e2a4_1feb_4ab5_ae64_ac4324e62ac8
type: Species
name: _AI222095_1_m
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI222095
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_e2d630ac_7d45_47c3_868a_da2bddb8d552
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
type: Species

metaM orn c
name: Ornithine
has only substance units: false
is: HMDB00214
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:0
is: SBO:0000247
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
type: Species
constant: false

metaR NACASPAH
is: SBO:0000176
product: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.15
modifier: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
reversible: false
name: N-Acetyl-L-aspartate amidohydrolase
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110016#

metaM dcyt e
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
is: HMDB00014
is: C00881
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15698
type: Species

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: prostaglandin E1(1-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57397

metaR r2082
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r2326
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2397
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: false

metaR r0579
is described by: ECO:0000000
modifier: MODEL1310110016#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
product: MODEL1310110016#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM pchol hs e
has only substance units: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
is: CHEBI:16110
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1533
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false

metaR r2100
reversible: true
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185

metaR RE2972M
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.67
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
name: RE2972

metaM HC01397 x
type: Species
boundary condition: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:27402
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

http://identifiers.org/biomodels.db/MODEL1310110016#_dc677093_4ddb_4509_817a_c6fc5d6913b9
is encoded by: hsa:5167
is: P22413
boundary condition: true
name: ENPP1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_8bf5803d_9cea_4879_a283_5cdd29e4101a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:514
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
is encoded by: hsa:513
constant: false
boundary condition: true
is: SBO:0000297

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_24bd6373_48a1_4f35_9263_568866f11133
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:622
initial concentration: NaN
boundary condition: true
has only substance units: false
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110016#_6b6450c6_ea2a_4ed8_a00c_71a1d7078f42
is encoded by: hsa:762
initial concentration: NaN
is: Q6FHI7
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: CA4
has only substance units: false
initial amount: NaN

metaR RE2814R
type: Reaction
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
product: MODEL1310110016#
reversible: true
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000000

metaM ncam c
initial amount: NaN
is: CHEBI:0
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247
constant: false
type: Species
is: HMDB01406
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Nicotinamide
is: C00153

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#

metaM glu L e
name: L-glutamate(1-)
is: HMDB00148
is: CHEBI:29985
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
constant: false
type: Species

metaR RE3627M
is described by: ECO:0000000
type: Reaction
reversible: true
name: RE3627
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#

metaM ribflv e
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: C00255
initial amount: NaN
is: HMDB00244
has only substance units: false
type: Species
constant: false
is: CHEBI:3554
name: Riboflavin

metaR r2325
reactant: MODEL1310110016#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
is: SBO:0000185

metaM ksi deg10 l
is: CHEBI:16953
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
boundary condition: false
is: HMDB00812
initial amount: NaN
name: keratan sulfate I, degradation product 10
constant: false
has only substance units: false
type: Species

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
name: fatty acid transport via diffusion

metaM pa hs c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57739

metaR r2083
reversible: true
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110016#

metaM pram c
is: CHEBI:58681
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: SBO:0000247
is: C03090
name: 5-Phospho-beta-D-ribosylamine
is: HMDB01128
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_fa532929_49ee_400b_b08e_2420a87ad072
type: Species
name: CPT2
initial amount: NaN
has only substance units: false
is: P23786
constant: false
initial concentration: NaN
is encoded by: hsa:1376
boundary condition: true
is: SBO:0000252

metaR r2398
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaM xyl D c
has only substance units: false
name: aldehydo-D-xylose
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15936

metaR GLYCTDle
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
type: Reaction
name: difussion of glycerol accross the brush border membrane

metaM icit c
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00193
constant: false
is: C00311
is: CHEBI:16087
name: Isocitrate
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_22b739ca_1a0e_4650_8bb9_2ed32b9e9aa8
is: P48735
name: IDH2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3418
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaR GLUDxm
is version of: http://identifiers.org/ec-code/1.4.1.3
type: Reaction
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110016#
is: SBO:0000176

metaR MI134PP
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.57
fast: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reversible: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#

metaR r0236
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
type: Reaction
is: SBO:0000176

metaR RPEc
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
name: ribulose 5-phosphate 3-epimerase
fast: false
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_8312c195_7c75_4806_91c6_1f1e1a71c021
constant: false
has only substance units: false
initial concentration: NaN
name: PLCXD2
initial amount: NaN
is encoded by: hsa:257068
type: Species
is: Q0VAA5
boundary condition: true
is: SBO:0000252

metaM gmp g
type: Species
is: CHEBI:58115
is: HMDB01397
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP(3-)

metaR CMPSASn
name: CMP sialic acid synthase, nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110016#
type: Reaction

metaM m2emgacpail hs r
is: C00080
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
boundary condition: false
is: CHEBI:24636

metaM 5aizc c
boundary condition: false
is: C04751
is: CHEBI:58564
constant: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
has only substance units: false
is: HMDB06273

http://identifiers.org/biomodels.db/MODEL1310110016#_46166364_8301_4fdf_ade9_3a6bd3a0f0a8
type: Species
is: SBO:0000252
has only substance units: false
name: ALOX5
boundary condition: true
is encoded by: hsa:240
initial amount: NaN
is: P09917
initial concentration: NaN
constant: false

metaM orn e
is: HMDB00214
initial amount: NaN
name: Ornithine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:0
is: SBO:0000247
is: C01602
constant: false
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR RE3326M
reactant: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
reversible: true
product: MODEL1310110016#
name: RE3326
kinetic law: MODEL1310110016#

metaR FAOXC161C141x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_59f82a99_5625_44e7_90d0_6ae77170e5cf
is: Q9NRA0
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SPHK2
boundary condition: true
is encoded by: hsa:56848

metaR BACCL
is described by: ECO:0000269
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110016#
fast: false
type: Reaction
product: MODEL1310110016#
name: biotin-[acetyl-CoA-carboxylase] ligase

metaR GLB1
kinetic law: MODEL1310110016#
is: SBO:0000176
name: Beta-galactosidase
reactant: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000

metaM pchol hs c
constant: false
name: Phosphatidylcholine
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16110
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR r2391
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false

metaR ADSL2
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110016#
name: adenylosuccinate lyase
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176

metaM cholate c
name: Cholate
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
is: HMDB00619
initial amount: NaN
is: CHEBI:29747
initial concentration: 1.0
type: Species

metaR 3MOPt2im
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110016#_0d136803_5164_4a47_8e6f_70c29afa2d58
is encoded by: hsa:26289
boundary condition: true
name: AK5
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a561ac82_6ec8_42fb_b899_248f0a47e625
is: SBO:0000252
constant: false
name: AK5
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:26289
is: Q9Y6K8
type: Species

metaR r2328
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r2102
kinetic law: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_90c5ad90_65f7_4577_88a9_5542f015e70f
type: Species
is: SBO:0000252
is: Q7Z5T0
initial concentration: NaN
name: SLC1A3
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6507

metaR ACACt2
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
modifier: MODEL1310110016#
name: acetoacetate transport via proton symport
product: MODEL1310110016#

metaR r2084
modifier: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_814b2f05_f6c1_4e69_850b_2da8a438a355
has only substance units: false
boundary condition: true
name: SLC7A8
initial concentration: NaN
is encoded by: hsa:23428
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9UHI5
constant: false

metaR RE2625M
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110016#
type: Reaction
name: RE2625
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM ac m
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: CHEBI:30089
is: HMDB00042
name: acetate
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaM ribflv c
constant: false
name: Riboflavin
type: Species
boundary condition: false
is: HMDB00244
is: C00255
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110016#_56d476d9_d5c5_468f_9af7_f1ff6f3d760a
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4831
constant: false
name: NME2
is: SBO:0000252
type: Species
is: P22392

metaR PROSTGH2t
fast: false
is: SBO:0000185
name: Prostaglandin H2 transport
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction

metaM arachcoa e
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:15527
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
is: SBO:0000247
name: arachidyl coenzyme A
constant: false

metaM chol c
boundary condition: false
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
initial amount: NaN
has only substance units: false
is: C00114
initial concentration: 1.0
is: CHEBI:15354
is: SBO:0000247
is: HMDB00097
constant: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_c7d1fd4b_c108_4288_8243_852b04f52ca9
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q99943
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:10554
initial concentration: NaN
name: AGPAT1

metaR O2t
reversible: true
reactant: MODEL1310110016#
name: o2 transport (diffusion)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
product: MODEL1310110016#

metaM xyl D e
name: aldehydo-D-xylose
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
is: CHEBI:15936
is: SBO:0000247
initial concentration: 1.0

metaR INSTt4
name: inositol transport via sodium symport
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110016#
product: MODEL1310110016#

metaR r0779
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110016#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR URIt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
reversible: true
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
name: uridine facilated transport in cytosol
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_bbaad8d2_bfb4_4f08_8a1d_aeb2f0af7165
initial concentration: NaN
initial amount: NaN
name: NME1:NME2
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4830
constant: false
is: SBO:0000297

metaR 2OXOADOXm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.61
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000304
modifier: MODEL1310110016#
product: MODEL1310110016#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)

metaR EBP1r
reactant: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
product: MODEL1310110016#
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
type: Reaction
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR r2085
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110016#

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ac580b8a_1fb8_447c_a021_66ee2020b316
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:51227
type: Species
name: PIGP

metaR r2327
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#

metaR r2101
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM 3mox4hpac m
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB05175
is: CHEBI:28111
has only substance units: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial concentration: 1.0

metaM HC02149 m
has only substance units: false
is: CHEBI:28867
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: O-Propanoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110016#_c55f357d_fef0_4189_8cd0_7e9f1bde1df2
type: Species
constant: false
name: SLC27A4
initial concentration: NaN
initial amount: NaN
is: Q6P1M0
boundary condition: true
has only substance units: false
is encoded by: hsa:10999
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_bbd348d6_e664_4de2_b696_d6ef10ee789c
has only substance units: false
boundary condition: true
constant: false
has part: Q8TBF5
name: PIGX:PIGM
initial amount: NaN
type: Species
is encoded by: hsa:54965
is: SBO:0000297
is encoded by: hsa:93183
has part: Q9H3S5
initial concentration: NaN

metaR TYRt
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110016#
name: L-tyrosine transport
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110016#
type: Reaction

metaR r0165
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40

metaR r0233
is version of: http://identifiers.org/ec-code/4.2.1.22
is: SBO:0000176
name: UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase Galactose metabolism / Nucleotide sugars metabolism EC:2.7.7.12
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:10993714 NOTES:
fast: false
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6f90a69a_38ca_4789_bae2_5ea2e04a1587
initial concentration: NaN
has only substance units: false
name: NDUFB9
is encoded by: hsa:4715
boundary condition: true
type: Species
is: SBO:0000252
is: Q9Y6M9
initial amount: NaN
constant: false

metaM cholate e
boundary condition: false
is: SBO:0000247
name: Cholate
constant: false
is: HMDB00619
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
has only substance units: false
is: CHEBI:29747
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_1c33c122_7f4a_4ed5_8680_69fa1f86e831
initial concentration: NaN
boundary condition: true
is: P30084
is: SBO:0000252
name: ECHS1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:1892
initial amount: NaN

metaR r1544
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaM ksi deg13 l
type: Species
initial amount: NaN
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00812
constant: false
name: keratan sulfate I, degradation product 13
is: CHEBI:16953

metaR r2104
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#

metaR r2086
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_71502baa_3638_4bfb_95bd_94fca7ea80f2
is: Q9H6Y6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: MYO5B
is encoded by: hsa:4645
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9c059e63_ca40_4c42_a4fb_11f51ed997c2
name: PRDX3
boundary condition: true
is encoded by: hsa:10935
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: P30048
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ab6ee869_2e18_4626_b6fa_760de0a17c69
constant: false
name: ATP5A1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:498
is: P25705
type: Species
initial amount: NaN

metaM dhap x
is: C00111
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
is: CHEBI:57642
constant: false
type: Species
is: HMDB01473

metaM 6htststerone r
name: 6 beta hydroxy testosterone
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/17395497
is: C14497
initial concentration: 1.0
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 EHMN_ABBREVIATION: C14497
type: Species
is: HMDB06259
is: SBO:0000247

metaR ST8SIA54g
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
product: MODEL1310110016#
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110016#
is described by: ECO:0000269
type: Reaction

metaM 2mp2coa m
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01011
initial amount: NaN
name: 2-Methylprop-2-enoyl-CoA
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
has only substance units: false
initial concentration: 1.0

metaM HC00342 c
boundary condition: false
is: CHEBI:16383
constant: false
initial amount: NaN
is: SBO:0000247
name: cis-aconitate(3-)
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaR FAOXC10C8x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM hyptaur e
has only substance units: false
initial amount: NaN
is: HMDB00965
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Hypotaurine
constant: false
is: CHEBI:16668

metaM chol e
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: C00114
type: Species
boundary condition: false
is: CHEBI:15354
initial concentration: 1.0
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline

metaR r0166
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
fast: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_d79fcf58_f347_434a_ae35_9ae27b636826
initial concentration: NaN
has part: Q99519
is encoded by: hsa:2720
has part: P10619
constant: false
is: SBO:0000297
type: Species
has part: P34059
is encoded by: hsa:4758
initial amount: NaN
boundary condition: true
is encoded by: hsa:2588
is encoded by: hsa:5476
has part: P16278
has only substance units: false
name: GALNS:GLB1:NEU1:CTSA

http://identifiers.org/biomodels.db/MODEL1310110016#_241810bc_035e_4c25_a442_526ae6474d7c
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI469183
type: Species
is: SBO:0000252
name: _AI469183_1_x

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaM hco3 m
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
is: C00288
constant: false
is: HMDB00595
name: Bicarbonate
is: CHEBI:17544
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
is: SBO:0000247
name: UMP(2-)
type: Species
is: HMDB00288
boundary condition: false
has only substance units: false

metaR 2DR1PP
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
type: Reaction
is: SBO:0000176
reversible: false

metaR r2087
is: SBO:0000185
modifier: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110016#

metaR GTHP
name: glutathione peroxidase
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.9
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_14b2e389_3dcf_4ad0_b319_a6c9bb1ceabf
has part: A8K761
has part: F8VQS7
initial amount: NaN
has part: B1AM93
has part: Q6IBC4
is encoded by: hsa:4536
has only substance units: false
has part: Q7GXZ4
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4537
is encoded by: hsa:4695
is encoded by: hsa:4707
is encoded by: hsa:4731
has part: O95168
has part: O75251
has part: O00483
has part: P19404
is: SBO:0000297
is encoded by: hsa:4704
is encoded by: hsa:4700
has part: Q85KV6
has part: P28331
is encoded by: hsa:4717
initial concentration: NaN
has part: O95167
is encoded by: hsa:4713
is encoded by: hsa:4726
is encoded by: hsa:4710
has part: E5KNH5
is encoded by: hsa:4723
type: Species
has part: O00217
has part: C9JT23
has part: Q9P0J0
has part: Q7GXZ1
is encoded by: hsa:4720
has part: Q6IBA0
is encoded by: hsa:4539
is encoded by: hsa:4697
is encoded by: hsa:4535
is encoded by: hsa:4709
has part: O95169
is encoded by: hsa:4540
is encoded by: hsa:55967
has part: O75489
is encoded by: hsa:4694
has part: O43674
has part: O14561
is encoded by: hsa:4706
has part: H7C5B8
is encoded by: hsa:4702
has part: P03915
has part: Q6IB80
has part: P56181
is encoded by: hsa:4719
boundary condition: true
is encoded by: hsa:51079
is encoded by: hsa:4716
is encoded by: hsa:4712
has part: O43181
is encoded by: hsa:4729
has part: Q6FG42
has part: Q549M5
is encoded by: hsa:4725
has part: Q9Y6M9
is encoded by: hsa:126328
has part: Q7GXY9
is encoded by: hsa:7991
is encoded by: hsa:4722
has part: Q16795
has part: Q13454
has part: B7Z792
is encoded by: hsa:374291
has part: O95299
has part: Q6IBB5
has part: Q16718
is encoded by: hsa:4538
is encoded by: hsa:4696
constant: false
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110016#_f4801ad8_a996_47e5_bbd7_9a0437e23230
boundary condition: true
name: MGLL
constant: false
is encoded by: hsa:11343
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q99685
type: Species

metaM ei11ecoa x
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: 11-eicosenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110016#_c37fef18_cac6_419a_88ad_d930aefa6516
has only substance units: false
constant: false
is encoded by: hsa:55350
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: VNN3
initial amount: NaN

metaR r2329
fast: false
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaM dcyt c
is: C00881
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:15698
initial concentration: 1.0
constant: false
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
boundary condition: false
is: HMDB00014

metaM pa hs g
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
initial amount: NaN
is: CHEBI:57739
name: phosphatidate(2-)
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ff4bf24f_59bb_44b5_ae8f_588d0eef1e35
is: SBO:0000252
name: NDUFS4
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: O43181
is encoded by: hsa:4724
constant: false
type: Species

metaM cl c
initial concentration: 1.0
is: CHEBI:3966
type: Species
name: Chloride
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
initial amount: NaN
is: C00115
is: HMDB00492
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c2be5cca_ca30_416c_a19c_3d614c8228f8
is encoded by: hsa:64077
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9H008
has only substance units: false
name: LHPP
initial amount: NaN
boundary condition: true
constant: false

metaM nrpphr c
constant: false
is: SBO:0000247
is: CHEBI:33569
initial concentration: 1.0
type: Species
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
has only substance units: false
is: HMDB00216
initial amount: NaN
boundary condition: false

metaR GLYt4
is: SBO:0000185
name: glycine transport via sodium symport
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
is described by: ECO:0000269

metaM dhcholestanate x
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
is: HMDB00359
initial amount: NaN
type: Species
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110016#_475a892e_687f_46fa_981c_5c4e96b04f63
is encoded by: hsa:56301
type: Species
is: Q9NS82
initial amount: NaN
has only substance units: false
name: SLC7A10
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR RE1897C
type: Reaction
fast: false
reversible: true
product: MODEL1310110016#
is: SBO:0000176
name: RE1897
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_b22e62a6_12e0_4a90_a6eb_92684752457c
is: SBO:0000252
constant: false
is encoded by: hsa:55350
has only substance units: false
boundary condition: true
initial amount: NaN
name: VNN3
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_de54f34c_0fa9_496e_8989_fddfe8400d4f
initial amount: NaN
type: Species
constant: false
name: CMPK1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51727
boundary condition: true
is: B2R6S5
initial concentration: NaN

metaR MANtly
type: Reaction
name: mannose efflux from lysosome
is: SBO:0000185
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110016#
fast: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ed404649_95a0_47f6_b379_ac65f8a906a3
is encoded by: hsa:9962
boundary condition: true
initial amount: NaN
name: SLC23A2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_c567b805_7b27_419b_8ebf_a021df4e073f
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: _AW299740_1_m
is encoded by: hsa:AW299740
has only substance units: false

metaR r2437
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false

metaR r1546
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110016#
is: SBO:0000185

metaR r0908
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR N3Tg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.1.122
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
reversible: false
fast: false
is: SBO:0000176

metaM cl e
initial amount: NaN
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
has only substance units: false
name: Chloride
constant: false
is: C00115
is: SBO:0000247
boundary condition: false
is: HMDB00492
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_3f541cae_9a08_424e_b9f7_4dad61e234d3
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4716
initial amount: NaN
name: NDUFB10
is: A8K761
is: SBO:0000252
has only substance units: false

metaR ALDD2xm
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110016#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
fast: false
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
reversible: false

metaR ORNDC
name: Ornithine Decarboxylase
reversible: false
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.1.1.17
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance

http://identifiers.org/biomodels.db/MODEL1310110016#_419e16d1_34e2_42ff_bbc6_e572e8ceb511
is: Q5JAM2
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:211
name: ALAS1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR RE2814M
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
type: Reaction
reversible: true

metaM 3hpcoa m
constant: false
is: HMDB06807
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
boundary condition: false
is: CHEBI:58528
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM C04849 e
is: SBO:0000247
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial amount: NaN
type: Species
is: CHEBI:57449
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
initial concentration: 1.0

metaR HRETNtn
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
name: 4-hydroxyretinoic acid transport, Nuclear
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_851c8153_40c8_4d34_8d4c_5a5b434c92eb
is: SBO:0000252
name: NADSYN1
is encoded by: hsa:55191
is: Q6IA69
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM ksi deg21 l
name: keratan sulfate I, degradation product 21
initial concentration: 1.0
is: CHEBI:12936
type: Species
initial amount: NaN
is: HMDB00143
has only substance units: false
boundary condition: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_23a9cbea_5d23_4430_9c10_1fa60582d373
initial concentration: NaN
is: Q9UN76
is: SBO:0000252
name: SLC6A14
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:11254
constant: false

metaM lnlncgcoa c
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
type: Species
is: HMDB06368
is: CHEBI:57363
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
has only substance units: false

metaR r0570
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.3.3.2
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7

metaR CHOLt4
type: Reaction
is described by: ECO:0000269
name: choline, sodium cotransport
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
modifier: MODEL1310110016#

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
constant: false
is: CHEBI:28766
is: SBO:0000247
type: Species
initial concentration: 1.0
name: UroporphyrinogenI
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5ab4942c_24e9_4815_b6e0_d217a643c392
is encoded by: hsa:25769
has only substance units: false
type: Species
name: SLC24A2
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9UI40
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_28714c11_2f6a_43f4_af57_9258899063d4
type: Species
initial concentration: NaN
boundary condition: true
has part: E5KS60
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000297
is encoded by: hsa:8803
name: SUCLG1:SUCLA2

metaR r0425
reversible: true
is version of: http://identifiers.org/ec-code/1.17.1.4
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
name: EC:1.1.1.42
fast: false
type: Reaction
product: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_a7a51eed_39ca_440d_8802_87862887c3eb
initial concentration: NaN
name: HSD3B1
initial amount: NaN
has only substance units: false
is encoded by: hsa:3283
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: P14060

metaM 13dampp c
name: trimethylenediaminium
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: CHEBI:57484
initial concentration: 1.0
constant: false
type: Species
is: HMDB00002
has only substance units: false

metaR r1548
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_a877deb9_90b5_4678_a793_c5d11af967c3
initial concentration: NaN
name: RHBG
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57127
constant: false
type: Species
is: Q9H310

http://identifiers.org/biomodels.db/MODEL1310110016#_73e82c2b_a9d9_47e6_91d1_dea82d774cdd
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2582
initial amount: NaN
boundary condition: true
name: GALE
constant: false
type: Species
is: Q38G75

metaR DNDPt35m
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
kinetic law: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
is described by: ECO:0000269

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: Aminobutyraldehyde dehydrogenase
is: SBO:0000176
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000269
fast: false

metaR NCAMUP
reversible: false
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: Nicotinamide acid uptake

metaR r0426
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
fast: false
reversible: true
modifier: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#

metaM 2mpdhl m
initial amount: NaN
constant: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: CHEBI:16110
constant: false
name: Phosphatidylcholine
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM dd3coa x
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
name: 3-dodecenoylcoa
is: HMDB04257
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e7d88243_04a0_4da3_a003_9d2b1db40e70
boundary condition: true
name: ATP5D
initial amount: NaN
type: Species
is: P30049
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:513
is: SBO:0000252

metaM Rtotal l
constant: false
initial amount: NaN
name: R total
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:52639
has only substance units: false
is: SBO:0000247

metaR NAGLCAly
name: N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
fast: false

metaM dttp m
is: CHEBI:37568
is: C00459
is: HMDB01342
initial amount: NaN
is: SBO:0000247
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM ump r
is: HMDB00288
constant: false
is: SBO:0000247
name: UMP
is: CHEBI:57865
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110016#_808c5f21_0dc1_4eab_b550_04e8c0139e48
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q9HBH5
boundary condition: true
constant: false
is encoded by: hsa:57665
name: RDH14
initial concentration: NaN

metaM sarcs c
is: CHEBI:3513
notes: FORMULA: C3H7NO2 CHARGE: 0
initial concentration: 1.0
is: C00213
name: Sarcosine
initial amount: NaN
has only substance units: false
is: HMDB00271
is: SBO:0000247
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_548b0399_7327_4864_bdb0_4d0e135d0753
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: SOD1
is encoded by: hsa:6647
is: P00441
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_aa806cb9_bafa_4a7b_a2e3_867b3a7118a3
boundary condition: true
type: Species
initial concentration: NaN
name: ATP5G1
constant: false
is encoded by: hsa:516
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q6FIH7

metaR r1882
modifier: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR LNLCCRNt
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
product: MODEL1310110016#
type: Reaction

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM orn m
initial concentration: 1.0
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
is: CHEBI:46912
type: Species
name: Ornithine
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c59166c3_219a_4a79_b877_f5a41de3a7cb
initial amount: NaN
is: P78381
initial concentration: NaN
is encoded by: hsa:7355
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC35A2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a0610c20_58da_4dd6_8be3_a38e70aed980
is encoded by: hsa:50484
constant: false
initial concentration: NaN
type: Species
is: Q7LG56
is: SBO:0000252
initial amount: NaN
name: RRM2B
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_100e4b5b_9eb1_4818_9a92_22937c100f86
initial amount: NaN
type: Species
is: P51648
constant: false
initial concentration: NaN
is encoded by: hsa:224
is: SBO:0000252
name: ALDH3A2
has only substance units: false
boundary condition: true

metaR CRNtHa
fast: false
product: MODEL1310110016#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
name: L-carnitine outward transport (H+ antiport)

http://identifiers.org/biomodels.db/MODEL1310110016#_a35fbc3f_c3b5_408d_989c_1651a6804736
is encoded by: hsa:AF116616
initial concentration: NaN
constant: false
initial amount: NaN
name: _AF116616_1_m
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaM HC01231 c
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58480
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM dttp n
boundary condition: false
is: CHEBI:37568
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
initial concentration: 1.0
has only substance units: false
name: dTTP
is: C00459
is: HMDB01342
is: SBO:0000247

metaR SGALSIDEtg
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
name: sgalside hs intracellular transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r1547
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ac e
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
name: acetate
is: CHEBI:30089
constant: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR GLCAASE9ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110016#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110016#

metaR CYANt
product: MODEL1310110016#
reversible: true
is: SBO:0000185
type: Reaction
name: Cyanide transport via diffusion (extracellular to cytosol)
fast: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM

metaM glu L c
boundary condition: false
is: SBO:0000247
constant: false
name: L-glutamate(1-)
initial concentration: 1.0
type: Species
is: HMDB00148
has only substance units: false
is: CHEBI:29985
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM mmcoa S m
is: HMDB02310
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
name: (S)-methylmalonyl-CoA(5-)
is: CHEBI:57327
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_c1355cf3_8c34_4da2_a3e0_aeadbeca962d
is encoded by: hsa:AI348006
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _AI348006_1_c
initial concentration: NaN

metaR SGALSIDEtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110016#
reversible: true
is described by: ECO:0000000
name: sgalside hs intracellular transport
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_4e1e52c7_cba4_4e92_bc42_f5c57fb98ccc
initial concentration: NaN
constant: false
boundary condition: true
name: CKMT1B
is: P12532
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1159
is: SBO:0000252

metaM thbpt4acam n
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r2433
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_6e612a42_a1b4_49eb_8c68_90fee069b964
is: P08319
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:127
name: ADH4
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR MI34PP
reversible: false
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
type: Reaction
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
name: inositol-3,4-bisphosphate 4-phosphatase
is described by: ECO:0000269
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.66
is: SBO:0000176
kinetic law: MODEL1310110016#

metaR PPItx
product: MODEL1310110016#
is: SBO:0000185
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

metaR S6TASE25ly
reversible: true
type: Reaction
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR NACHEX11ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2d288309_37d7_4f4d_92b9_5a6394adf18c
is: SBO:0000252
is encoded by: hsa:22934
type: Species
is: P49247
initial concentration: NaN
has only substance units: false
name: RPIA
constant: false
boundary condition: true
initial amount: NaN

metaR r0384
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
product: MODEL1310110016#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false

metaR r0999
name: Facilitated diffusion
reactant: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110016#
type: Reaction

metaR SUCOAS1m
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_e597eb08_eb3c_46a1_b221_9eb625880ab3
initial amount: NaN
type: Species
has only substance units: false
is: B2RDZ2
is encoded by: hsa:55312
initial concentration: NaN
boundary condition: true
constant: false
name: RFK
is: SBO:0000252

metaR HMGCOASim
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_39f8d76b_6685_42a9_84ad_1f55c51e84fe
type: Species
boundary condition: true
initial concentration: NaN
name: ALDH4A1
is encoded by: hsa:8659
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6973d67c_a234_4f5e_893e_442876fb226d
is: SBO:0000252
has only substance units: false
name: PIGN
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23556
boundary condition: true
type: Species
constant: false

metaR r1527
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_e2154069_e457_4eab_b930_9eda314e1de8
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI761708
boundary condition: true
constant: false
has only substance units: false
name: _AI761708_1_m
initial concentration: NaN

metaR GTHPm
name: glutathione peroxidase, mitochondria
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15

http://identifiers.org/biomodels.db/MODEL1310110016#_47af59c0_7664_4f9b_81cb_31d4f3651c84
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5538
constant: false
name: PPT1
boundary condition: true
is: Q6FGQ4
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6691e8e5_3540_4228_aa48_4b10067e5fdb
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI620219
is: SBO:0000252
name: _AI620219_1_e

metaR FUMTSULtm
modifier: MODEL1310110016#
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110016#
is: SBO:0000185
product: MODEL1310110016#
type: Reaction

metaR GLCtly
is: SBO:0000185
reactant: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: glucose efflux from lysosome
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000

metaR r1549
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR 3HBCOAHLm
reversible: false
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_a236ddfa_d220_43f7_820b_bb17d1485db4
is: SBO:0000252
name: GALNT13
initial concentration: NaN
boundary condition: true
is: Q8IUC8
initial amount: NaN
is encoded by: hsa:114805
type: Species
constant: false
has only substance units: false

metaR MMEm
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110016#

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM hdd2coa c
is: HMDB03945
boundary condition: false
is: SBO:0000247
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C05272
type: Species
constant: false
name: trans-Hexadec-2-enoyl-CoA

metaR LEUKTRA4tr
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
name: leukotriene intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
product: MODEL1310110016#

metaR TRDR
kinetic law: MODEL1310110016#
name: thioredoxin reductase (NADPH)
type: Reaction
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_248596b6_1ebe_4062_a215_1cb6fc65599e
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: PEMT
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10400

metaM succ m
name: Succinate
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: C00042
is: HMDB00254
initial amount: NaN
is: CHEBI:30031
initial concentration: 1.0
type: Species

metaR AIRCr
modifier: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110016#
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.6
product: MODEL1310110016#
name: phosphoribosylaminoimidazole carboxylase

metaR MTHFDm
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110016#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: acetate
boundary condition: false
type: Species
is: HMDB00042
is: CHEBI:30089
initial concentration: 1.0

metaR GDPtg
reactant: MODEL1310110016#
name: GDP intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_9ea426c8_58bb_4690_9ee8_192a1669083a
name: PPA1
has only substance units: false
is: Q15181
is: SBO:0000252
type: Species
is encoded by: hsa:5464
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7c59a6e2_1260_468f_a988_afdac55d35bf
initial amount: NaN
initial concentration: NaN
name: SLCO1A2
boundary condition: true
is: P46721
has only substance units: false
type: Species
is encoded by: hsa:6579
constant: false
is: SBO:0000252

metaM ins c
name: Inosine
constant: false
initial amount: NaN
is: C00294
initial concentration: 1.0
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
is: HMDB00195
has only substance units: false
is: CHEBI:17596
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b4f67e7a_fed6_4fa1_9b27_6985d3c2820d
boundary condition: true
initial amount: NaN
is: P48448
initial concentration: NaN
name: ALDH3B2
is: SBO:0000252
is encoded by: hsa:222
type: Species
constant: false
has only substance units: false

metaM dadp c
is: HMDB01508
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: C00206
has only substance units: false
initial amount: NaN
name: dADP
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57667

metaM ump n
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
constant: false
initial amount: NaN
is: CHEBI:57865
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r0386
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reversible: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction

metaR r0575
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_44f3d910_9900_4986_a1d5_746f272d753b
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:276
has only substance units: false
name: AMY1A
constant: false
is: Q6NSB3

metaR RE1526M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1526
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_80e4e2ba_e88c_4827_9384_f0553b202994
name: SLC1A6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6511
initial amount: NaN
is: P48664
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR r2435
reversible: false
reactant: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR HDD2COAtx
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
name: hdd2coa intracellular transport
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction

metaM retn r
type: Species
name: all-trans-retinoate
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01852
is: CHEBI:35291
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false

metaM malthp e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
name: maltoheptaose
constant: false
is: SBO:0000247
is: C01936
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaM ksii core4 deg2 l
initial amount: NaN
boundary condition: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
constant: false
type: Species
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936

metaM r5p c
has only substance units: false
constant: false
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
is: SBO:0000247
is: C00117
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_4362ccff_1aa9_46d6_b0ac_edad21ed2332
is: E5KS60
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8803
type: Species
initial concentration: NaN
name: SUCLA2
boundary condition: true

metaR CHOLATEt
modifier: MODEL1310110016#
is: SBO:0000185
name: cholate transport via bicarbonate countertransport
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
product: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_12668881_d6fa_4fff_8274_257d5f766ab9
initial amount: NaN
type: Species
is: SBO:0000297
initial concentration: NaN
boundary condition: true
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
has only substance units: false

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
reactant: MODEL1310110016#
type: Reaction
fast: false
kinetic law: MODEL1310110016#
reversible: true
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/5.3.99.2
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_466811ff_2221_490e_b7a3_ed30939e536a
is encoded by: hsa:4706
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: O14561
initial amount: NaN
name: NDUFAB1

metaR NDPK2n
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110016#

metaR r0423
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM C02528 r
name: chenodeoxycholate
is: CHEBI:36234
initial amount: NaN
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR r0909
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaR r0385
is: SBO:0000176
reversible: false
type: Reaction
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110016#

metaR MECOAS1m
modifier: MODEL1310110016#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110016#
type: Reaction
name: mesaconate--CoA ligase (GDP-forming)
is: SBO:0000176
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#

metaR r0998
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Facilitated diffusion

metaR NADPHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110016#
name: NADPH transporter, endoplasmic reticulum
kinetic law: MODEL1310110016#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c0e04db7_dfac_4036_b2fc_b137296032b7
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:PRO1933
name: _PRO1933_1_m
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_545da621_025b_4dbe_ab75_546e93d42fc9
is: P30838
is encoded by: hsa:218
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ALDH3A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bb9d0443_e594_40a0_9630_d6858d7270e0
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: _AI924226_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AI924226

http://identifiers.org/biomodels.db/MODEL1310110016#_3049631e_87e3_4e03_8c8b_2a9bd165edcd
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:286016
type: Species
name: TPI1P2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_59c0f200_2d5c_458e_b75f_cbaeb1df1c8c
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM hs deg10 l
name: heparan sulfate, degradation product 10
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
initial amount: NaN
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
constant: false
boundary condition: false

metaR RE2626C
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
is: SBO:0000176
name: RE2626
is described by: ECO:0000000

metaM k c
name: potassium
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
type: Species
constant: false
is: HMDB00586
is: CHEBI:29103
boundary condition: false
has only substance units: false
initial amount: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM pro L e
is: HMDB00162
constant: false
type: Species
name: L-proline
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR PPNCL3
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110016#
fast: false
type: Reaction
reversible: false
name: phosphopantothenate-cysteine ligase
reactant: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_3e002a1a_d279_4016_97a5_274b0bfcbbb9
name: CRAT
has only substance units: false
type: Species
initial amount: NaN
is: P43155
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1384

metaM gtp c
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
has only substance units: false
type: Species
is: C00044
boundary condition: false
name: GTP
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:37565
is: SBO:0000247

metaM amp c
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: CHEBI:3322
is: HMDB00045
is: C00020
name: AMP
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaM ade e
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
is: CHEBI:16708
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: adenine
has only substance units: false
type: Species

metaM mi14p n
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: CHEBI:58282
is: HMDB00968
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR SO4HCOtex
type: Reaction
name: sulfate transport via bicarbonate countertransport
reversible: false
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000304
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185

metaM pdx5p c
is: SBO:0000247
is: HMDB01319
initial amount: NaN
is: C00627
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
initial concentration: 1.0
name: Pyridoxine 5'-phosphate
type: Species
constant: false
boundary condition: false
is: CHEBI:58589
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a382c7b3_7295_4191_b22d_69772a481a09
name: PLA2G1B
boundary condition: true
is encoded by: hsa:5319
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: P04054

metaM core5 g
is: C04383
has only substance units: false
name: Core 5
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110016#_a0f02e25_7cfc_4e72_bd47_1938bc616216
initial concentration: NaN
has only substance units: false
type: Species
name: LDHA
is: SBO:0000252
is encoded by: hsa:3939
is: P00338
constant: false
initial amount: NaN
boundary condition: true

metaM HC00342 m
type: Species
has only substance units: false
is: CHEBI:16383
is: SBO:0000247
boundary condition: false
name: cis-aconitate(3-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaR r0388
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
kinetic law: MODEL1310110016#
is: SBO:0000176

metaM acald m
initial concentration: 1.0
name: acetaldehyde
is: CHEBI:15343
is: HMDB00990
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR r1396
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: EC:2.3.1.21
reversible: false
reactant: MODEL1310110016#

metaM ha pre1 e
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaM taur c
name: Taurine
boundary condition: false
is: CHEBI:3544
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
is: SBO:0000247
is: HMDB00251
has only substance units: false

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
reversible: true
type: Reaction

metaR NaKt
is described by: ECO:0000269
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.3.9
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is: SBO:0000185
name: Na+/K+ exchanging ATPase
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
reversible: false
product: MODEL1310110016#
fast: false

metaM udpacgal g
constant: false
boundary condition: false
has only substance units: false
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

http://identifiers.org/biomodels.db/MODEL1310110016#_27e75096_b83c_4af3_b0d4_3516c335b7dd
has only substance units: false
initial concentration: NaN
is encoded by: hsa:501
type: Species
is: E7EPT3
name: ALDH7A1
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_ce62751f_11ed_4642_b626_1778ae36e465
initial amount: NaN
is: P37837
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6888
has only substance units: false
is: SBO:0000252
name: TALDO1

http://identifiers.org/biomodels.db/MODEL1310110016#_4125a86b_6a11_4293_954e_ffbb214c8a65
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: NDUFC1
is: O43677
is encoded by: hsa:4717

http://identifiers.org/biomodels.db/MODEL1310110016#_12f12796_1379_45cd_aa9f_0378674065c9
boundary condition: true
constant: false
has part: Q15102
initial amount: NaN
initial concentration: NaN
has part: A8DPS7
is encoded by: hsa:5050
is encoded by: hsa:5049
name: PAFAH1B2:PAFAH1B3
is: SBO:0000297
type: Species
has only substance units: false

metaR FUMSO4tm
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
reversible: true
fast: false
name: Fumarate:sulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR BAMPPALDOX
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
is described by: ECO:0000212
is: SBO:0000176

metaR r1397
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
name: carnitine acetyltransferase EC:2.3.1.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: false

metaM HC02149 c
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: CHEBI:28867
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: O-Propanoylcarnitine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_337170d1_966b_4a4f_962a_4dbe3a4c7847
name: _7359_1_c
constant: false
is encoded by: hsa:7359
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM pro L c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: L-proline
is: HMDB00162
type: Species
is: CHEBI:17203
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
has only substance units: false

metaM ocdcea l
has only substance units: false
constant: false
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
is: SBO:0000247
initial concentration: 1.0
name: oleate
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:30823

metaM odecoa c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB01322
is: CHEBI:3793
type: Species
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)

metaR r0389
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
is described by: ECO:0000000
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
reactant: MODEL1310110016#

metaR BTND1n
name: biotinidase (biotin), nuclear
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM 3mob c
is: HMDB00019
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:11851
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
boundary condition: false
name: 3-methyl-2-oxobutanoate

metaM dttp e
name: dTTP(4-)
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:37568
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: SBO:0000247
is: HMDB01342

metaM k e
has only substance units: false
name: potassium
is: C00238
initial concentration: 1.0
constant: false
type: Species
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR PPItr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
reversible: true
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#

metaR UMPK6n
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP),nuclear
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaM gcald c
has only substance units: false
is: CHEBI:17071
constant: false
name: glycolaldehyde
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB03344
is: SBO:0000247

metaR CYTK1m
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000134
product: MODEL1310110016#
fast: false
name: cytidylate kinase (CMP),mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
type: Reaction
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_5f22dbed_865c_446f_b32d_3bd180672c6d
has only substance units: false
is encoded by: hsa:205
name: AK4
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P27144
constant: false
initial concentration: NaN
type: Species

metaR PI4PLC
is described by: ECO:0000269
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction

metaM ade c
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16708
type: Species
boundary condition: false
is: C00147
name: Adenine
initial amount: NaN
is: HMDB00034

metaM drib e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28816
is: HMDB03224
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
name: 2-deoxy-D-ribose

http://identifiers.org/biomodels.db/MODEL1310110016#_06cbcd52_87b1_4bca_a985_edfda639ecff
boundary condition: true
is: SBO:0000252
is: P49189
initial amount: NaN
name: ALDH9A1
is encoded by: hsa:223
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
name: cholesterol precursor intracellular transport
product: MODEL1310110016#

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1b1b4f4b_1638_4742_b87b_a0ba6478fec1
boundary condition: true
is encoded by: hsa:5281
is: SBO:0000252
is: Q07326
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: PIGF

metaR RE1447N
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: RE1447
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_0461fc97_c8e2_4ba3_b6a6_ca2ec096d284
boundary condition: true
has only substance units: false
type: Species
name: CYP3A7
is: P24462
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1551

metaR CYTK1n
is: SBO:0000176
reactant: MODEL1310110016#
type: Reaction
fast: false
kinetic law: MODEL1310110016#
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110016#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM HC02214 e
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
initial amount: NaN
name: prostaglandin-f1alpha
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28852

metaM HC01397 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:27402
constant: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

metaM xoldiolone r
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
has only substance units: false
is: CHEBI:28477
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02197
constant: false

metaR biomass reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
product: MODEL1310110016#
fast: false
name: biomass_reaction
is described by: ECO:0000134
type: Reaction
is: SBO:0000185

metaR AK2LGCHOLt
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_b1eef84c_0815_4c97_97c8_ff2a0e16d950
is: F5H8B1
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5833
has only substance units: false
initial concentration: NaN
name: PCYT2

metaR AMPtp
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110016#
type: Reaction
name: AMP transporter, peroxisome
kinetic law: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_fe7b64b5_71a2_4694_8ae1_74111e1b777d
name: GGT7
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:2686
constant: false
is: SBO:0000252
has only substance units: false
is: A0PJJ9
initial concentration: NaN

metaR DM hretn n
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4 hydroxy retinoic acid demand
type: Reaction

metaM 3mob e
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: SBO:0000247
boundary condition: false
type: Species
name: 3-methyl-2-oxobutanoate
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:11851
is: HMDB00019

metaR SARDHm
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
fast: false
name: Sarcosine dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.5.99.1
product: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_bdd38bd2_91d4_4016_a919_462b7f903c5c
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:195814
is: B3KT84
name: SDR16C5
type: Species
constant: false

metaM ksi deg32 l
is: CHEBI:12936
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 32
constant: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: SBO:0000247

metaR r0679
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_12abfe7c_1227_435d_8383_249f65497b91
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: Q86SK9
boundary condition: true
type: Species
name: SCD5
initial amount: NaN
is encoded by: hsa:79966

http://identifiers.org/biomodels.db/MODEL1310110016#_c721bce1_6e1e_4f05_afb2_4ae2829f14b4
initial concentration: NaN
is: B7Z4Y6
is encoded by: hsa:249
initial amount: NaN
name: ALPL
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR FOLTle
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: folate uptake into the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6bf0a2d1_d243_426c_b228_3562c18fb220
is encoded by: hsa:7378
constant: false
initial concentration: NaN
name: UPP1
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: Q16831
initial amount: NaN

metaM prostgd2 e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
is: HMDB01403
name: prostaglandin D2(1-)
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_04dd6bae_a0b6_4418_9425_d00a0acf6b98
is: Q9P0J0
is encoded by: hsa:51079
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: NDUFA13
boundary condition: true
is: SBO:0000252

metaM ksi deg18 l
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 18
is: SBO:0000247

metaR GLYt2r
kinetic law: MODEL1310110016#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110016#
reversible: true
name: glycine reversible transport via proton symport
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
fast: false

metaR PSSA1 hs
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
reactant: MODEL1310110016#
reversible: true
name: Phosphatidylserine synthase homo sapiens

http://identifiers.org/biomodels.db/MODEL1310110016#_32ab46d4_bc8f_4677_bcae_72adf697993a
is: SBO:0000252
boundary condition: true
name: ABCD1
constant: false
initial concentration: NaN
is encoded by: hsa:215
is: P33897
has only substance units: false
type: Species
initial amount: NaN

metaM btn e
is: C00120
is: CHEBI:3420
name: Biotin
is: HMDB00030
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM dadp n
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: dADP(3-)
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
is: CHEBI:57667

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_d0d3ddec_9b28_48bf_8301_6ca3d16032cb
type: Species
is encoded by: hsa:443
boundary condition: true
has only substance units: false
is: Q6FH48
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: ASPA

metaM CE1944 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:36781
constant: false
has only substance units: false
name: 1-pyrrolinium

metaM so3 m
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00240
initial concentration: 1.0
name: hydrogensulfite
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
type: Species
is: CHEBI:17137
is: SBO:0000247

metaR MI14PP
kinetic law: MODEL1310110016#
name: inositol-1,4-bisphosphate 1-phosphatase
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.57
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reactant: MODEL1310110016#

metaM hdd2coa m
is: C05272
is: SBO:0000247
is: CHEBI:61526
initial amount: NaN
initial concentration: 1.0
is: HMDB03945
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA

metaM thbpt4acam c
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB02281
initial amount: NaN
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

http://identifiers.org/biomodels.db/MODEL1310110016#_26cb8358_210c_4260_9d4b_c5602332f88b
constant: false
is encoded by: hsa:117247
name: SLC16A10
is: Q8TF71
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM ptth c
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB03426
has only substance units: false
is: SBO:0000247
name: pantetheine

metaM udpacgal l
is: HMDB00304
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
is: CHEBI:57847
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ea11a596_f12c_42e1_8707_44c82c10b55e
is: SBO:0000252
is encoded by: hsa:AI090874
constant: false
boundary condition: true
type: Species
has only substance units: false
name: _AI090874_1_c
initial concentration: NaN
initial amount: NaN

metaM HC02214 c
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
has only substance units: false
name: prostaglandin-f1alpha
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28852
is: SBO:0000247

metaR r0009
type: Reaction
reactant: MODEL1310110016#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
fast: false
product: MODEL1310110016#
reversible: false
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.6.1.1

metaM dadp m
is: HMDB01508
is: CHEBI:57667
name: dADP(3-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_92b031f6_d278_41e7_ab98_d2f031851d63
name: NDUFS7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:374291
has only substance units: false
is: SBO:0000252
constant: false
is: O75251
type: Species
boundary condition: true

metaM hretn c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06254
has only substance units: false
boundary condition: false
notes: FORMULA: C20H27O3 CHARGE: -1
name: 4 hydroxy retinoic acid
initial amount: NaN
constant: false

metaM HC01602 c
type: Species
is: CHEBI:57454
initial amount: NaN
is: SBO:0000247
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
constant: false
initial concentration: 1.0
is: C00234
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b1d716b5_0201_483a_a3ff_c29df1b59332
initial concentration: NaN
initial amount: NaN
is: P13995
is: SBO:0000252
has only substance units: false
name: MTHFD2
constant: false
boundary condition: true
is encoded by: hsa:10797
type: Species

metaR RE1447M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_b63dedb0_f501_4831_a5e5_b380fdd6e5eb
boundary condition: true
type: Species
initial amount: NaN
is: Q9BYZ2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:92483
name: LDHAL6B
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_ac2728a2_15b0_4734_b96c_c9c8d648328d
boundary condition: true
is encoded by: hsa:2879
name: GPX4
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: P36969

metaR 13DAMPPOX
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110016#
is described by: ECO:0000212
reactant: MODEL1310110016#
reversible: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176

metaR r1464
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110016#
name: Active transport
is: SBO:0000185
product: MODEL1310110016#

metaR CYSGLYexR
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: L-cysteine/glycine reversible exchanger
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6eb41bc9_1a46_42f8_8356_040f5e8e5cc2
boundary condition: true
name: ATP5J
type: Species
is encoded by: hsa:522
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_e1ad9b0b_7a58_4ffb_b12e_823d25217087
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30
name: ACAA1
type: Species
constant: false

metaM amp e
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
initial concentration: 1.0
initial amount: NaN
name: AMP
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:456215

metaM 2oxoadp m
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57499
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
name: 2-oxoadipate(2-)
constant: false
type: Species

metaR CYTK9n
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP),nuclear
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
reversible: true
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR PPItm
product: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000185
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.

metaM prostgd2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57406
name: prostaglandin D2(1-)
is: HMDB01403
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_90a0ec17_577b_4066_940a_88287756b564
constant: false
type: Species
is: A0N0X8
initial amount: NaN
has only substance units: false
name: CYP1A1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1543
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_a714e6d1_a893_4bc1_ad48_8be4a70aaa7d
constant: false
has only substance units: false
is encoded by: hsa:1152
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: CKB
is: P12277

metaM hmgcoa c
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:15467
type: Species
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
is: HMDB01375

metaM btn c
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: CHEBI:3420
is: HMDB00030
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaM taur e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
name: Taurine
constant: false
is: HMDB00251
is: C00245
boundary condition: false
is: CHEBI:3544

http://identifiers.org/biomodels.db/MODEL1310110016#_b6529ffe_60fd_4c72_adfb_7e615b8ca059
initial amount: NaN
initial concentration: NaN
is: P57054
boundary condition: true
name: PIGP
is: SBO:0000252
constant: false
is encoded by: hsa:51227
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_5b6461fa_5be9_4bac_8bcf_2f34e8434da1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1503
name: CTPS1
is: P17812
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaM ser L e
is: HMDB00187
initial amount: NaN
type: Species
name: L-serine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
constant: false
is: CHEBI:17115

metaR r0787
product: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
modifier: MODEL1310110016#

metaM pro L m
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00162
type: Species
boundary condition: false
constant: false
name: L-proline

metaM ptth e
name: pantetheine
has only substance units: false
boundary condition: false
is: HMDB03426
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
initial amount: NaN
is: CHEBI:16753

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
type: Reaction

metaR ASNPHELAT2tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR AHCYStd
type: Reaction
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
name: diffusion of S-Adenosyl-L-homocysteine
is described by: ECO:0000134
kinetic law: MODEL1310110016#
is: SBO:0000185

metaR NACHEX21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM ocdcea r
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00207
is: CHEBI:0
is: SBO:0000247
boundary condition: false
constant: false
is: C00712
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN

metaR CYTK8
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP,dATP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_d946b136_1774_41e8_a017_0ba5cc64f8f5
name: _AA081045_1_c
is: SBO:0000252
constant: false
is encoded by: hsa:AA081045
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaM HC01162 c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:58376
initial concentration: 1.0
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species
is: SBO:0000247

metaR CYTK6
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_939958a0_f826_41bc_bd84_d9c20b8aab65
constant: false
name: CKMT2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1160
initial amount: NaN
is: P17540

metaM succ c
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: CHEBI:30031
type: Species
is: HMDB00254
constant: false
boundary condition: false
initial amount: NaN
is: C00042
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5858cd3d_ac9e_4121_bbc6_926f60f084db
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4905
is: P46459
name: NSF
initial concentration: NaN

metaM C02528 c
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00518
name: chenodeoxycholate
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
has only substance units: false
is: CHEBI:36234

metaR GLCAASE1ly
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
name: beta-glucuronidase, lysosomal
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_48ec0aac_ffca_4328_a478_7d113acdbb80
is: Q9BV10
is: SBO:0000252
is encoded by: hsa:79087
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ALG12
boundary condition: true

metaR r0788
reversible: true
modifier: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_3b6f9e1f_f746_405f_8afc_b935cdfade97
initial amount: NaN
boundary condition: true
name: ALDH1B1
initial concentration: NaN
is: P30837
constant: false
is encoded by: hsa:219
type: Species
has only substance units: false
is: SBO:0000252

metaR ABTD
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
type: Reaction
reactant: MODEL1310110016#
reversible: true
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
product: MODEL1310110016#

metaR ALASm
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.37
product: MODEL1310110016#
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.29
kinetic law: MODEL1310110016#
name: 5-aminolevulinate synthase

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a88f6466_50e4_4b67_a82d_cc39b8977786
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6392
initial concentration: NaN
initial amount: NaN
name: SDHD
is: O14521
has only substance units: false

metaM dcyt n
name: 2'-deoxycytidine
is: CHEBI:15698
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00014
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
is: SBO:0000247

metaR r2106
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f9d7aab6_721f_4797_b3bb_9e0997e0021b
has only substance units: false
type: Species
is encoded by: hsa:8871
initial amount: NaN
name: SYNJ2
is: O15056
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_69d52b99_15a4_4627_aca8_87e9bd2f966f
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:728441
boundary condition: true
is: SBO:0000252
name: GGT2
constant: false
type: Species

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM etfox m
is: CHEBI:16469
name: Electron transfer flavoprotein oxidized
boundary condition: false
type: Species
is: HMDB00151
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: R CHARGE: 0
initial concentration: 1.0

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
reversible: true
name: cytidylate kinase (CMP,UTP)

http://identifiers.org/biomodels.db/MODEL1310110016#_0278d43a_eefe_4ab9_929f_d73c9e21b1d1
initial amount: NaN
name: AGPAT6
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q86UL3
is: SBO:0000252
type: Species
is encoded by: hsa:137964

metaR r0085
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaM ser L c
is: HMDB00187
boundary condition: false
initial amount: NaN
name: L-serine
is: SBO:0000247
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaM ha pre1 l
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
constant: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.31
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_64bc1f12_09d7_421e_a449_e97887df4431
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: NDUFA5
is encoded by: hsa:4698
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q16718

http://identifiers.org/biomodels.db/MODEL1310110016#_e93d54ec_cf54_46db_9c9c_004b82fcc995
initial concentration: NaN
name: CKB:CKM
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1158
is: SBO:0000297
has part: B2R892

metaM CE2435 m
boundary condition: false
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
has only substance units: false

metaR CKc
kinetic law: MODEL1310110016#
name: ATP Creatine kinase (c)
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.3.2
notes: GENE_ASSOCIATION: (1152.1) or (1158.1) and (1152.1) or (1158.1) SUBSYSTEM: Urea cycle EC Number: 2.7.3.2 Confidence Level: 4 AUTHORS: PMID:2883200,PMID:3034271 NOTES:kegg C02305 MJC SAB c
is: SBO:0000176
fast: false
modifier: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#

metaR r2107
reactant: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
reversible: true
type: Reaction
kinetic law: MODEL1310110016#

metaR r0789
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110016#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR FAOXC14C12x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_8592ac9a_6f08_4dc1_9214_d01ecace330a
boundary condition: true
is encoded by: hsa:28231
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: SLCO4A1
has only substance units: false
is: Q96BD0

metaR r0086
type: Reaction
product: MODEL1310110016#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110016#

metaM 3hmp m
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
boundary condition: false
is: HMDB00023
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
constant: false
has only substance units: false
type: Species

metaM gua c
is: SBO:0000247
is: C00242
type: Species
constant: false
is: HMDB00132
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
name: Guanine
is: CHEBI:16235
has only substance units: false

metaR r2079
fast: false
modifier: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110016#

metaR ACGAMPM
type: Reaction
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: true
name: phosphoacetylglucosamine mutase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.4.2.3
modifier: MODEL1310110016#

metaM gluala e
has only substance units: false
name: 5-L-Glutamyl-L-alanine
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: C03740
is: HMDB06248
constant: false
is: http://identifiers.org/pubchem.compound/6503
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

http://identifiers.org/biomodels.db/MODEL1310110016#_78d9e991_17c3_4c2d_aaa4_f1cc556ec0d2
has only substance units: false
is encoded by: hsa:4728
is: SBO:0000252
name: NDUFS8
boundary condition: true
constant: false
type: Species
is: O00217
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_04b3fc56_5cee_452f_88d6_edd2791b5681
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI684467_1_m
is encoded by: hsa:AI684467
type: Species
initial amount: NaN
constant: false

metaM retn e
boundary condition: false
initial concentration: 1.0
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
name: all-trans-retinoate
is: HMDB01852
has only substance units: false
is: SBO:0000247
constant: false
type: Species

metaR ALAtN1
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
name: Alanine transport (Na, H coupled)
reversible: true

metaR DOLMANP Uter
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110016#

metaM hs deg4 l
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
name: heparan sulfate, degradation product 4
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
constant: false
initial amount: NaN

metaM HC00229 e
name: Isomaltose
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_efd401a3_fe3a_414b_af92_927f1c81fbca
boundary condition: true
type: Species
name: SLC12A4
initial amount: NaN
is encoded by: hsa:6560
is: F5H066
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR AKR1D
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110016#
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110016#

metaM icit m
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
is: HMDB00193
initial concentration: 1.0
is: C00311
type: Species
name: Isocitrate
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR GBA
reactant: MODEL1310110016#
is described by: ECO:0000000
modifier: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
name: Glucosylceramidase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.45
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_10fad5e0_b7d5_4cdc_bc03_9f615e9ca485
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:197257
name: LDHD
constant: false

metaR RE2626M
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
name: RE2626
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

metaR DNDPt41m
is: SBO:0000185
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: dUTP transport via dCDP antiport
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_00405096_869a_4ab3_9b21_620e8de0f696
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1607
name: DGKB
initial concentration: NaN
type: Species

metaR r2108
is described by: ECO:0000000
product: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_2152b20a_ca4a_449f_ac36_2e6d8a2e7bd5
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6520
name: SLC3A2
is: P08195
boundary condition: true
constant: false
is: SBO:0000252

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM HC00319 c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
is: CHEBI:30794
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
name: Malonate

metaR ADKd
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
reversible: true
is: SBO:0000176
type: Reaction

metaR CYTK9
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP,dCTP)
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_3258df46_448e_41fe_aa64_031aae238cf8
has only substance units: false
boundary condition: true
name: ENTPD8
is: Q5MY95
is encoded by: hsa:377841
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_98f6068f_f33e_4ee3_9d34_25e7e293b453
has only substance units: false
is: O43674
is: SBO:0000252
is encoded by: hsa:4711
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NDUFB5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_c156087e_2ae3_4e4f_a0fe_4ba21b776fdc
is: P04075
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: ALDOA
is encoded by: hsa:226

http://identifiers.org/biomodels.db/MODEL1310110016#_94ad62c5_7ff5_43ad_ae66_9b530bd183fc
boundary condition: true
is: B3KWF4
type: Species
is: SBO:0000252
is encoded by: hsa:63917
name: GALNT11
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR r2109
is: SBO:0000185
reversible: true
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e8662350_8d45_451b_af99_e5683fb58841
constant: false
initial amount: NaN
is: O95427
name: PIGN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23556
initial concentration: NaN
type: Species
has only substance units: false

metaR FAS180COA
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
reversible: false
name: fatty-acyl-CoA synthase (n-C18:0CoA)
modifier: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is: SBO:0000176

metaR r0783
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
fast: false
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_917d3ded_347c_4df7_ac54_57e42a5d92c3
is: O75038
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: PLCH2
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:9651

metaM 44mctr r
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17813
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
type: Species
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023

metaM dhcholestanate m
initial amount: NaN
is: CHEBI:16577
is: HMDB00359
type: Species
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8d59c743_9350_4647_9336_8373ad5f1cea
boundary condition: true
is encoded by: hsa:2023
is: SBO:0000252
constant: false
is: E2DRY6
name: ENO1
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM dttp c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:37568
type: Species
is: C00459
name: dTTP
has only substance units: false
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
initial amount: NaN

metaR r0670
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM hs deg25 l
constant: false
notes: FORMULA: C23H37O21 CHARGE: -1
is: CHEBI:16126
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_35055d91_a430_4b8f_84f6_8b8daa8e3ae7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1374
name: CPT1A
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: Q8WZ48
boundary condition: true

metaM retn c
initial concentration: 1.0
is: CHEBI:35291
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
name: all-trans-retinoate
is: HMDB01852

metaR RTOTALFATPc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM gua e
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
name: guanine
is: CHEBI:16235
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_db1c2b7b_9d56_4664_b04d_4a3169dd5975
has only substance units: false
is: P55084
is encoded by: hsa:3032
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: HADHB

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6edefe68_b55c_404b_bc3c_d39637ee320d
is encoded by: hsa:AA532636
has only substance units: false
name: _AA532636_1_m
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaM gdpfuc g
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57984
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: GDP-L-fucose(2-)

metaR S6TASE24ly
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110016#
reversible: true

metaR r0899
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
product: MODEL1310110016#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR ALAGLNexR
reactant: MODEL1310110016#
name: L-alanine/glutamine reversible exchange
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000304
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_b7cf7cc2_e417_41e5_8a23_cd3363281a8f
has only substance units: false
constant: false
is encoded by: hsa:1376
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P23786
initial concentration: NaN
name: CPT2

metaM malttr e
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:27931
initial concentration: 1.0
is: C01835
boundary condition: false
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
type: Species
is: HMDB01262
name: maltotriose

http://identifiers.org/biomodels.db/MODEL1310110016#_5055c30c_f93e_4066_b6fb_d155477fd793
type: Species
boundary condition: true
constant: false
name: HIBCH
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q6NVY1
initial concentration: NaN
is encoded by: hsa:26275

http://identifiers.org/biomodels.db/MODEL1310110016#_1dc5a48d_ec5e_4541_b277_f64c35ef3298
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c
constant: false
has only substance units: false

metaR r0784
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110016#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
kinetic law: MODEL1310110016#

metaR CYTK13n
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110016#
name: cytidylate kinase (dCMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR RE3628M
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110016#
reversible: true
name: RE3628
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_d0f03543_04a7_49e3_bfd4_f5e8cde45a62
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P31645
name: SLC6A4
constant: false
boundary condition: true
is encoded by: hsa:6532
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_62a0ab1e_979b_4933_9df1_f33e395f6213
has only substance units: false
constant: false
is encoded by: hsa:5831
is: A6NFM2
name: PYCR1
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_de6241ba_f534_4b51_8917_2fc502739b75
is: P05091
type: Species
is encoded by: hsa:217
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: ALDH2
initial concentration: NaN
boundary condition: true

metaR DCK1n
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
reversible: true
product: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
name: Deoxycytidine kinase, nuclear (ATP)

http://identifiers.org/biomodels.db/MODEL1310110016#_82497a9c_671f_4157_a1ae_4281e32cf472
is encoded by: hsa:3550
has only substance units: false
name: IK
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: Q13123
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_f9cb6cdb_12fc_4794_80d7_9a6796db5075
has only substance units: false
is encoded by: hsa:521
constant: false
name: ATP5I
is: P56385
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR r2320
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110016#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0081
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_5fcecb28_976c_4d69_beb8_ba74e67084dd
is encoded by: hsa:5860
is: P09417
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: QDPR
boundary condition: true
has only substance units: false
type: Species

metaR LAPCOAe
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110016#
is described by: ECO:0000134
name: LAPCOAe
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: false

metaM malcoa c
is: CHEBI:57384
initial amount: NaN
name: Malonyl-CoA
is: C00083
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01175

metaR r0002
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Active transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_4b32c78b_268b_46f6_ba9d_ce2c8cf72abd
is encoded by: hsa:3704
is: Q9BY32
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
name: ITPA
initial concentration: NaN
initial amount: NaN

metaR LINOFATPtc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM 3mob m
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
constant: false
is: HMDB00019
initial concentration: 1.0
boundary condition: false
is: CHEBI:11851

metaR ADNt5le
fast: false
modifier: MODEL1310110016#
name: adenosine transport (1:2 Na/Adn cotransport)
kinetic law: MODEL1310110016#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR r0672
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
fast: false
reactant: MODEL1310110016#
reversible: true
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_72e32d2b_bc38_4d3f_80ca_36fa23b21df1
initial amount: NaN
is: P11310
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ACADM
constant: false
is encoded by: hsa:34

metaR LTC4Sr
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.4.1.20
is: SBO:0000176
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
reversible: false
name: Leukotriene C4 synthase
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9cdea31b_8252_4afb_a489_dae409c7f34b
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC4A5
is encoded by: hsa:57835
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_e92c1ecd_20de_4eb1_81db_8c1e0a492d59
type: Species
is encoded by: hsa:5631
is: SBO:0000252
initial amount: NaN
name: PRPS1
boundary condition: true
is: P60891
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_c579a3d5_2d56_4917_acc2_0c9f195273c1
has only substance units: false
name: SLC7A9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P82251
constant: false
boundary condition: true
is encoded by: hsa:11136
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_3454623e_f6a2_4196_85b7_ae42c399edfc
name: GLB1
is: SBO:0000252
is: P16278
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2720
has only substance units: false
initial concentration: NaN

metaM prostge1 e
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442
is: CHEBI:57397
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_fdb9d04d_5742_4958_85ff_577aff2afe5c
initial concentration: NaN
is: Q02218
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4967
name: OGDH
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM pep c
initial concentration: 1.0
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00263
is: SBO:0000247
name: Phosphoenolpyruvate
constant: false
is: C00074
boundary condition: false
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1310110016#_bea6de40_01ae_401b_874d_0e9d45b7faa3
name: AUH
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:549
is: Q13825
constant: false

metaR r2321
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR DAGK hs
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_e8387e66_05a7_4373_b162_32e0e6ed23ee
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: G3V0F6
type: Species
initial amount: NaN
is encoded by: hsa:8525
name: DGKZ
constant: false
boundary condition: true

metaM malcoa e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
has only substance units: false
constant: false
name: malonyl-CoA(4-)
is: CHEBI:57384
is: HMDB01175
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_73564c76_9123_4085_a54c_af6072e9dfdd
is: SBO:0000252
name: SLC29A2
has only substance units: false
type: Species
is: Q14542
initial concentration: NaN
constant: false
is encoded by: hsa:3177
boundary condition: true
initial amount: NaN

metaM 3mgcoa m
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57346
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231

metaM ksii core2 deg1 l
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
is: SBO:0000247
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial concentration: 1.0
is: CHEBI:57737
constant: false
is: HMDB00868
initial amount: NaN
has only substance units: false

metaM acald c
boundary condition: false
is: HMDB00990
name: acetaldehyde
type: Species
constant: false
is: CHEBI:15343
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR EX alaala LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for alanylalanine
type: Reaction

metaR PIK4n
is: SBO:0000176
reversible: false
fast: false
name: phosphatidylinositol 4-kinase, nuclear
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110016#

metaM ttdca e
initial concentration: 1.0
name: tetradecanoate (n-C14:0)
type: Species
constant: false
is: C06424
has only substance units: false
is: CHEBI:30807
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: HMDB00806

metaM bglc e
constant: false
is: SBO:0000247
name: beta-glucans
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

metaR r0083
type: Reaction
modifier: MODEL1310110016#
reversible: true
is: SBO:0000176
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r2322
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR SPHINGStl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185
name: sphingosine intracellular transport
type: Reaction
product: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_d49279cd_dda8_4478_a5be_5bdb14a3314f
has only substance units: false
constant: false
is encoded by: hsa:5169
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q308M7
initial amount: NaN
name: ENPP3

metaR r2195
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110016#
type: Reaction
reversible: true
kinetic law: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_57b1f2bb_7188_4e71_a706_5c248b9aee9b
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: _AI971036_1_c
has only substance units: false
is encoded by: hsa:AI971036
is: SBO:0000252
type: Species

metaR VITD3t2
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
is: SBO:0000185
name: Vitamin D3 uptake
type: Reaction
reversible: false

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
has only substance units: false
is: HMDB00812
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
type: Species
is: SBO:0000247

metaR NDPK3m
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000254
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false

metaR r1050
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110016#

metaM dolp U c
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57683
name: dolichyl phosphate(2-)

metaR r2314
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_915e84b9_932c_4179_8683_d71aebd43385
is encoded by: hsa:AA177072
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: _AA177072_1_c
has only substance units: false

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a73d2492_64c1_4d25_ba98_951da81ac042
has only substance units: false
is: SBO:0000252
name: _D87002_1_m
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:D87002
boundary condition: true

metaM lnlc e
type: Species
is: CHEBI:30245
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
constant: false
is: SBO:0000247
is: HMDB00673
has only substance units: false
name: linoleate
initial concentration: 1.0
boundary condition: false

metaM hdd2coa x
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
boundary condition: false
is: HMDB03945
initial amount: NaN
type: Species
is: CHEBI:61526
constant: false
initial concentration: 1.0
name: (E)-hexadec-2-enoyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d8c1e34c_b15a_4b96_ab8a_8eb52eefb7bf
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8525
name: DGKZ
type: Species
is: B7Z6M3
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM gal e
is: HMDB00143
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
initial amount: NaN
boundary condition: false
name: D-Galactose
initial concentration: 1.0
type: Species

metaR PTPAT
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.7.3
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
fast: false
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r1051
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
reversible: true
kinetic law: MODEL1310110016#

metaR BALAtmr
reactant: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Beta-alanine reversible mitochondrial transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

metaR r2196
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

metaR BILDGLCURt
kinetic law: MODEL1310110016#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
modifier: MODEL1310110016#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true

metaM em2emgacpail hs r
boundary condition: false
is: CHEBI:16240
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB03125

metaR r2313
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_0768ba54_0cfc_454d_8397_08bf2640e82b
has only substance units: false
boundary condition: true
name: NDUFV2
is encoded by: hsa:4729
constant: false
is: SBO:0000252
initial concentration: NaN
is: P19404
type: Species
initial amount: NaN

metaM hs deg20 l
has only substance units: false
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16126
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_ecf39967_44e8_4562_a17b_6a01bec09ff5
type: Species
constant: false
is encoded by: hsa:5048
is: P43034
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PAFAH1B1
initial amount: NaN
has only substance units: false

metaR LEUt5m
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
name: leucine mitochondrial transport
reactant: MODEL1310110016#
product: MODEL1310110016#

metaM btn n
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57586
name: biotinate
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: SBO:0000247
is: HMDB00030

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR HESTRATRIOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_d5f1d7eb_7244_45e4_98c3_e04f1fd328c5
is: Q6IB54
is encoded by: hsa:522
type: Species
boundary condition: true
name: ATP5J
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ebb0c6bd_152c_4de6_8bb1_ab1446c9bb1d
initial concentration: NaN
is encoded by: hsa:2936
boundary condition: true
is: SBO:0000252
type: Species
name: GSR
initial amount: NaN
has only substance units: false
is: P00390
constant: false

metaR ARACHDtr
kinetic law: MODEL1310110016#
name: intracellular transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR DNDPt25m
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
name: dTDP transport via dCDP antiport
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269

metaR CYTK1
is described by: ECO:0000269
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
name: cytidylate kinase (CMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reversible: true
product: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: D-Serine/Glutamine reversible exchange
fast: false
kinetic law: MODEL1310110016#
type: Reaction

metaR r2193
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_f4b60a4c_5944_4b8d_bea0_a9346fdc6eb7
is: P21589
name: NT5E
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4907

http://identifiers.org/biomodels.db/MODEL1310110016#_d3e06e92_e5ed_49ac_83b8_97aad0cb8dc8
name: _AI653169_1_c
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI653169

http://identifiers.org/biomodels.db/MODEL1310110016#_388abf8f_b7c2_414b_ae63_4ee5ea74369d
initial amount: NaN
initial concentration: NaN
type: Species
name: TRNT1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51095
constant: false
is: Q96Q11
boundary condition: true

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM tchola c
initial amount: NaN
constant: false
initial concentration: 1.0
name: taurocholic acid
boundary condition: false
is: HMDB00036
type: Species
is: CHEBI:36257
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

http://identifiers.org/biomodels.db/MODEL1310110016#_8157fd25_39d4_4ec4_8d07_d103aab0f2ca
initial amount: NaN
is: SBO:0000252
is: P07864
is encoded by: hsa:3948
constant: false
name: LDHC
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_6b7e97e9_d079_40b5_aa8f_9e060e1ad2d9
is: P10619
type: Species
is: SBO:0000252
boundary condition: true
name: CTSA
is encoded by: hsa:5476
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM ksii core4 deg1 l
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 1
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: HMDB00868

metaM but e
is: CHEBI:17968
initial concentration: 1.0
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
constant: false
is: HMDB00039
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_a8c218a5_3602_4770_a598_3c387f75582c
initial concentration: NaN
name: SLC24A4
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:123041
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_01296a2e_5040_4bcb_8988_62fab4201f5b
has only substance units: false
boundary condition: true
is encoded by: hsa:BF195998
constant: false
name: _BF195998_1_x
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_670a6a25_992a_4872_b26c_5ad00f720c67
initial concentration: NaN
constant: false
is encoded by: hsa:4723
name: NDUFV1
boundary condition: true
is: E5KNH5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_5fea978b_68c8_4c84_993a_dbed7ff9a7e8
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:518
initial concentration: NaN
name: ATP5G3
constant: false
type: Species

metaM hmgcoa m
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15467
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
boundary condition: false
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110016#_300beffd_2eb9_4620_90b6_7469ebf1fe76
boundary condition: true
is encoded by: hsa:218
is: P30838
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: ALDH3A1

metaR r2194
reversible: true
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

metaM udp r
initial amount: NaN
is: C00015
constant: false
is: CHEBI:58223
name: UDP
boundary condition: false
has only substance units: false
type: Species
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: SBO:0000247

metaR RE3524R
type: Reaction
fast: false
name: RE3524
reactant: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000176

metaM Asn X Ser Thr l
is: C01342
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:28938
type: Species
boundary condition: false
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
initial amount: NaN

metaR NDPK3n
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304
reversible: true
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR r1254
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
type: Reaction
name: EC:6.2.1.3
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176

metaR r2311
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_ce884ce7_19dd_4811_b146_e63b150eb9b3
constant: false
name: PIP5K1A
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8394
has only substance units: false
initial amount: NaN
is: Q99755
initial concentration: NaN

metaR r0879
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
product: MODEL1310110016#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR PTCRTD
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
fast: false
is described by: ECO:0000134
reversible: true
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
name: diffusion of putriscine into the endothelial cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_26a9ef70_288c_419d_aa83_b58217fff12f
is encoded by: hsa:2588
is: SBO:0000252
name: GALNS
is: P34059
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR RE2660C
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
name: RE2660
fast: false
product: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaR S2TASE2ly
reactant: MODEL1310110016#
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_7a1961c7_1a22_42d2_ac44_a9c867eff7b7
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P33121
is encoded by: hsa:2180
initial concentration: NaN
constant: false
name: ACSL1
boundary condition: true

metaM 3dhguln c
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
is: HMDB06334
initial amount: NaN
boundary condition: false
name: 3-dehydro-L-gulonate
initial concentration: 1.0
is: SBO:0000247

metaM 5oxpro c
is: CHEBI:57606
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00267
initial concentration: 1.0
boundary condition: false
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
constant: false

metaM nac c
is: CHEBI:0
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: HMDB01488
name: Nicotinate
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00253
boundary condition: false
type: Species

metaM CE2250 e
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
is: CHEBI:52328
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: 3-oxodocosanoyl-CoA

metaR GUAt
is described by: ECO:0000269
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
type: Reaction
is: SBO:0000185
name: Guanine transport
reactant: MODEL1310110016#
reversible: true

metaM 25aics c
is: CHEBI:58443
is: C04823
initial amount: NaN
is: HMDB00797
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823

http://identifiers.org/biomodels.db/MODEL1310110016#_b6f63c65_bc3d_4f65_b4c0_4f68f08370c8
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4707
is: O75438
type: Species
boundary condition: true
initial amount: NaN
name: NDUFB1
is: SBO:0000252

metaM tchola e
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: taurocholic acid
type: Species
initial concentration: 1.0
is: HMDB00036
boundary condition: false

metaR RE0935E
reactant: MODEL1310110016#
modifier: MODEL1310110016#
name: RE0935
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction

metaM dhlam m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:17694
name: dihydrolipoamide
is: HMDB00985
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: SBO:0000247
initial amount: NaN

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

metaR r0809
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
fast: false
name: Facilitated diffusion

metaM q10 e
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01072
name: ubiquinone-10
is: CHEBI:46245
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_39325341_21f9_4259_8d29_7e3890fed0d7
has only substance units: false
constant: false
is: B4DDW0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: RDH11
is encoded by: hsa:51109
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_2d9fb881_4cbd_471a_b507_2542fbec841a
initial amount: NaN
is encoded by: hsa:57678
is: SBO:0000252
name: GPAM
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q8N1G6

metaR CYTK4
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110016#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: true

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR CSNAT2m
modifier: MODEL1310110016#
name: carnitine O-aceyltransferase, mitochondrial
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR H7 TAer
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is: SBO:0000176
type: Reaction
reversible: false
fast: false
name: H7' transamidase, endoplasmic reticulum
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_9d02156c_2aa0_43e2_b89b_f85d6d056c2f
is: SBO:0000252
is encoded by: hsa:23057
is: Q9BZQ4
initial amount: NaN
name: NMNAT2
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaM but c
is: HMDB00039
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM sql r
has only substance units: false
is: HMDB00256
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: CHEBI:15440
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: squalene
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ba2088bd_fd78_443d_8295_a5846cd1ac9f
name: SLC17A2
type: Species
is encoded by: hsa:10246
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: O00624
initial amount: NaN

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR r2318
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaM dump n
is: HMDB01409
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:246422
type: Species
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_8260c3b7_c39a_4e0c_b639_887940cb54cd
is: SBO:0000252
name: PANK3
type: Species
is: Q9H999
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:79646
initial concentration: NaN
constant: false

metaM ethamp r
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
is: CHEBI:58190
is: SBO:0000247
name: O-phosphonatoethanaminium(1-)
type: Species
constant: false
is: HMDB00224

metaR r2317
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_2b8d92ec_13e8_4827_9163_25354d0c1260
boundary condition: true
is encoded by: hsa:84890
is: SBO:0000252
is: B3KXN9
initial amount: NaN
has only substance units: false
name: ADO
constant: false
type: Species
initial concentration: NaN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR ST3GAL21g
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
type: Reaction
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f7fe07cf_1beb_4b51_a7d0_19f3e737b14a
is: Q9H3S5
initial amount: NaN
type: Species
name: PIGM
boundary condition: true
constant: false
is encoded by: hsa:93183
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_a67db8e4_4eef_468f_8fc3_f5b7eb0de4a3
name: GMPPB
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:29925
initial amount: NaN
has only substance units: false

metaR r1252
name: EC:6.2.1.3
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110016#

metaM 10fthf m
constant: false
is: CHEBI:57454
type: Species
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
boundary condition: false
is: HMDB00972
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaR GLUPRT
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase
modifier: MODEL1310110016#
fast: false
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
type: Reaction
is: SBO:0000176

metaM nac e
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01488
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
type: Species
name: Nicotinate
is: C00253
is: CHEBI:0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e30d87bc_4b24_40d4_876c_93385cc231f6
is: Q85KV6
type: Species
name: ND1
is encoded by: hsa:4535
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5b579af7_2129_4967_b419_ec2e1a91ada2
type: Species
name: PLA2G12A
initial amount: NaN
is: Q542Y6
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:81579

metaR CYTK5
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110016#
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110016#

metaM 5oxpro e
is: CHEBI:57606
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00267
has only substance units: false
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
name: 5-oxoprolinate

metaM mi14p c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00968
initial concentration: 1.0
constant: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: CHEBI:58282
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_2a14c3a0_d1bc_46e7_950c_fb21f3db77ac
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P08842
is encoded by: hsa:412
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: STS

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_7a163812_24be_45fa_b75c_636a78e335c3
boundary condition: true
has only substance units: false
is encoded by: hsa:AI024818
initial concentration: NaN
type: Species
name: _AI024818_1_c
initial amount: NaN
is: SBO:0000252
constant: false

metaM bhb m
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
boundary condition: false
is: HMDB00011
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:10983
name: (R)-3-hydroxybutyrate

metaM ak2lgchol hs e
type: Species
is: C04317
constant: false
initial amount: NaN
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: http://identifiers.org/pubchem.compound/6975

http://identifiers.org/biomodels.db/MODEL1310110016#_197cdcef_dd42_4219_b412_a616768c84b7
constant: false
is: SBO:0000252
is encoded by: hsa:64077
name: LHPP
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9H008
boundary condition: true

metaM HC00900 c
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:30860
name: Methylmalonate
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

http://identifiers.org/biomodels.db/MODEL1310110016#_f8524e7d_a4af_4cb8_9f80_345f8b99f3a3
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:768
is: Q16790
boundary condition: true
name: CA9
constant: false

metaR PIt8
modifier: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000006
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter

metaR r2316
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR PAPStg
reversible: true
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
kinetic law: MODEL1310110016#
is described by: ECO:0000269
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_b65a4c43_9914_45f8_88e5_6fa740d2d318
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:285973
is: Q674R7
name: ATG9B
initial concentration: NaN
is: SBO:0000252

metaM q10 c
type: Species
initial amount: NaN
name: ubiquinone-10
is: HMDB01072
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bb848136_d4bf_41dd_ad45_6bbaac789b49
name: NME1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110016#_28958320_d57e_4d2a_b2b4_943e467b43a4
initial amount: NaN
has only substance units: false
is: Q8WUX1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:92745
constant: false
type: Species
initial concentration: NaN
name: SLC38A5

http://identifiers.org/biomodels.db/MODEL1310110016#_cf3c774a_ed8f_4aa5_8c6e_6e88155edc80
name: ATP2B3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:492
is: Q16720
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR PI345P5P
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
product: MODEL1310110016#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110016#
type: Reaction
reversible: false

metaR CYTK2
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
reversible: true
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110016#

metaR r1807
reversible: false
modifier: MODEL1310110016#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM udp l
is: CHEBI:58223
boundary condition: false
name: UDP(3-)
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: HMDB00295
has only substance units: false
is: SBO:0000247
type: Species

metaM apoC c
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
is: HMDB11111
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:33190
name: Apocarboxlase (no lys residue)

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM gal c
name: D-Galactose
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
is: HMDB00143
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:0

metaR TDPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176
name: thiamin pyrophosphatase, mitochondrial
reversible: false
type: Reaction

metaM ksii core4 e
name: keratan sulfate II (core 4-linked)
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
type: Species
is: CHEBI:17268
is: HMDB00211

metaR CHLtm
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
name: choline transport via diffusion (cytosol to mitochondria)

metaM e4hglu m
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331
boundary condition: false
has only substance units: false
constant: false
is: HMDB02273
name: erythro-4-hydroxy-L-glutamate(1-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r2315
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR KHte
is: SBO:0000185
fast: false
name: KHte
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR ASPDTDe
product: MODEL1310110016#
fast: false
is: SBO:0000185
is described by: ECO:0000134
name: D-aspartate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
reversible: true
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#

metaR PIt7
product: MODEL1310110016#
name: phosphate transport in/out via three Na+ symporter
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
fast: false

metaM dump m
type: Species
is: SBO:0000247
is: HMDB01409
boundary condition: false
is: CHEBI:246422
constant: false
has only substance units: false
initial concentration: 1.0
name: dUMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

metaM udp n
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00295
name: UDP(3-)

metaM hspg e
boundary condition: false
is: HMDB00719
is: SBO:0000247
name: heparan sulfate proteoglycan
is: CHEBI:15699
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d8b9675f_07cf_4e84_864f_3f34b842daa0
initial amount: NaN
initial concentration: NaN
is: B3KN25
type: Species
name: CEPT1
is: SBO:0000252
is encoded by: hsa:10390
has only substance units: false
boundary condition: true
constant: false

metaR r0156
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
fast: false
is: SBO:0000176
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

metaR r1897
kinetic law: MODEL1310110016#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_87ff917d_b19c_4864_b81e_28890fe4b807
name: NDUFB7
has only substance units: false
type: Species
is: P17568
initial amount: NaN
is encoded by: hsa:4713
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaM rnam c
type: Species
constant: false
is: SBO:0000247
name: N-Ribosylnicotinamide
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
is: HMDB00855
initial concentration: 1.0
is: CHEBI:15927

metaM ak2lgchol hs c
has only substance units: false
is: http://identifiers.org/pubchem.compound/6975
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: C04317
boundary condition: false

metaR CYTK3
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110016#
is described by: ECO:0000269
reactant: MODEL1310110016#
fast: false
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
modifier: MODEL1310110016#
name: cytidylate kinase (CMP)(GTP)

metaR XOL7AONEtr
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true
name: lipid, flip-flop intracellular transport

metaR LDH L
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
product: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
name: L-lactate dehydrogenase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110016#_b1cc40d3_0a03_4126_be25_d5abeb044d9e
is: Q9NRA2
constant: false
name: SLC17A5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26503
type: Species

metaM hxan e
name: hypoxanthine
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00157
initial concentration: 1.0
is: CHEBI:17368
has only substance units: false
type: Species

metaM damp c
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58245
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: HMDB00905
constant: false
name: dAMP(2-)

metaR Q10H2e
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reversible: true
reactant: MODEL1310110016#
name: transport of ubiquinol into lymph
type: Reaction
fast: false
product: MODEL1310110016#
is described by: ECO:0000134

metaR RE1898C
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: RE1898
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
reversible: true

metaM CE5786 e
is: HMDB02710
constant: false
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:27485
type: Species
is: SBO:0000247
name: kinetensin

metaM apoC m
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:32551
name: Apocarboxlase (no lys residue)
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB00182

metaM lnlnca c
name: alpha-linolenate
is: HMDB01388
has only substance units: false
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32387

http://identifiers.org/biomodels.db/MODEL1310110016#_cc80a1bd_d776_41d4_8bef_5d3bd792e18d
is encoded by: hsa:2194
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P49327
name: FASN

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16113
boundary condition: false
has only substance units: false
is: HMDB00067
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_64f85e06_0dc3_417d_b0f6_8fe6e16d45c9
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PECR
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:55825
is: Q9BY49

metaR r2201
kinetic law: MODEL1310110016#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction

metaM 3oddcoa m
is: SBO:0000247
has only substance units: false
name: 3-Oxododecanoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
is: CHEBI:27868

http://identifiers.org/biomodels.db/MODEL1310110016#_6393fc5b_2ab6_403a_9638_c18501f7d343
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC27A1
is encoded by: hsa:376497
initial concentration: NaN
initial amount: NaN

metaM gm1b hs g
initial concentration: 1.0
type: Species
is: CHEBI:15440
boundary condition: false
is: HMDB00256
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: GM1b
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110016#_6dd6c1c9_69bb_4c23_908c_71a01b273239
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AU149534_1_m
constant: false
is encoded by: hsa:AU149534
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_6c6bae0d_b842_4674_94c2_312854d5cf05
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10423
initial amount: NaN
constant: false
is: O14735
name: CDIPT
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_b7513a26_9bf0_4907_b065_835a90d6051f
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: B3KQH0
has only substance units: false
is encoded by: hsa:55343
initial amount: NaN
is: SBO:0000252
name: SLC35C1

http://identifiers.org/biomodels.db/MODEL1310110016#_97f684f9_82fb_4114_a894_c337e0ddf8d2
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: AKR1A1
initial amount: NaN
is encoded by: hsa:10327
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_87919693_11d0_46ad_a187_82aac99c2c87
initial concentration: NaN
is encoded by: hsa:221
has only substance units: false
is: P43353
type: Species
constant: false
name: ALDH3B1
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX gd1c hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GD1c (homo sapiens) exchange
type: Reaction

metaM udp g
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
name: UDP(3-)
boundary condition: false
initial amount: NaN
is: CHEBI:58223
is: HMDB00295
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_80f88ab4_6c42_41c8_a4bd_1930b338f217
is encoded by: hsa:AI631997
has only substance units: false
boundary condition: true
name: _AI631997_1_m
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_02e505ea_adc5_45bf_bb59_c4298bd840a8
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI601100_1_m
constant: false
initial concentration: NaN
is encoded by: hsa:AI601100

metaR GLYGLYCNc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylycine for uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_d8a18ac2_e14e_4904_87b3_edb0b55fe6ae
has only substance units: false
constant: false
name: B3GALT4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8705
is: B3KQP5
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_9b9d57c7_3cbd_487c_9363_1007d21654c3
has only substance units: false
type: Species
boundary condition: true
name: SUOX
initial concentration: NaN
is: P51687
is: SBO:0000252
is encoded by: hsa:6821
initial amount: NaN
constant: false

metaR r0584
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110016#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
fast: false

metaR r1895
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r2200
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_1366e590_d055_4446_89d0_7cad49471771
is: F8VQS7
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55967
boundary condition: true
initial concentration: NaN
name: NDUFA12

metaR r0917
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110016#_d17a5b5a_f152_4994_9bfe_726855266e40
has part: P30049
type: Species
constant: false
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P36542
is encoded by: hsa:514
has part: A8K092
has part: P06576
is encoded by: hsa:506
initial concentration: NaN
has part: P56381
is encoded by: hsa:498
is encoded by: hsa:509
initial amount: NaN
has only substance units: false
is: SBO:0000297
is encoded by: hsa:513

http://identifiers.org/biomodels.db/MODEL1310110016#_d1a670a8_9ce4_4d94_829d_631ddd46562d
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:9061
constant: false
initial amount: NaN
initial concentration: NaN
is: O43252
name: PAPSS1

metaR SGPL12r
kinetic law: MODEL1310110016#
reversible: false
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000304
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110016#
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ

http://identifiers.org/biomodels.db/MODEL1310110016#_6fb619d7_1aa8_4bb0_9530_bdcee177c27f
is encoded by: hsa:D87002
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: _D87002_1_e
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_847c4772_f3b2_419f_b4f3_fcd2f7758a14
name: ASRGL1
initial amount: NaN
is: Q7L266
is encoded by: hsa:80150
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR HAtly
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
reversible: false
type: Reaction
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f1659da5_c76b_4698_985f_e8cd74e8bf6e
name: SLC5A6
type: Species
is: Q9HD19
is encoded by: hsa:8884
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR ME2m
is version of: http://identifiers.org/ec-code/1.1.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.40
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
kinetic law: MODEL1310110016#
type: Reaction
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
name: malic enzyme (NADP), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110016#_1a791130_079f_4c30_a70d_77d2dab137c4
initial concentration: NaN
name: DGKG
type: Species
has only substance units: false
is encoded by: hsa:1608
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P49619

http://identifiers.org/biomodels.db/MODEL1310110016#_75c7ab72_0c6f_4ca1_92b5_69252919b241
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: B3GNT5
is: Q9BYG0
type: Species
is encoded by: hsa:84002

metaM didp n
is: HMDB03536
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:28823
is: SBO:0000247
initial concentration: 1.0
type: Species
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaR RE1527M
kinetic law: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
name: RE1527
is: SBO:0000176
reactant: MODEL1310110016#

metaR RE2349C
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: RE2349
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C

metaM hxan c
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
has only substance units: false
is: HMDB00157
initial amount: NaN
initial concentration: 1.0
type: Species
name: Hypoxanthine
is: C00262
boundary condition: false
is: SBO:0000247
constant: false

metaR XYLTt
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
reversible: true
fast: false
product: MODEL1310110016#

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR EX gltcho LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-taurocholic acid complex
type: Reaction

metaR r2319
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110016#
fast: false
type: Reaction
kinetic law: MODEL1310110016#

metaR RE3000M
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110016#
name: RE3000
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110016#

metaM cmpacna n
type: Species
is: CHEBI:57812
initial amount: NaN
is: HMDB01176
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM Nacasp m
has only substance units: false
initial amount: NaN
is: HMDB00812
constant: false
name: N-acetyl-L-aspartate(2-)
boundary condition: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
type: Species
is: CHEBI:16953
initial concentration: 1.0
is: SBO:0000247

metaM HC01405 m
initial concentration: 1.0
type: Species
is: CHEBI:28632
is: SBO:0000247
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: (S)-Hydroxyoctanoyl-CoA

metaR r0437
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110016#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#
name: deoxyuridine phosphorylase
is described by: ECO:0000269
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR

metaR MAL Lte
is: SBO:0000185
reversible: true
name: Transport of L-malate
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR GK1
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
name: guanylate kinase (GMP:ATP)

http://identifiers.org/biomodels.db/MODEL1310110016#_57f24838_1c72_4d8f_b3f0_13acfa290a0b
has only substance units: false
is: P00915
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: CA1
is encoded by: hsa:759
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_d95ead4d_e960_42b8_a640_9da5b88d3a2c
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: NT5C1B
has only substance units: false
boundary condition: true
is encoded by: hsa:93034
is: Q96P26
is: SBO:0000252

metaM anth c
boundary condition: false
initial amount: NaN
name: anthranilate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
type: Species
is: CHEBI:16567
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_31166051_22e1_4a47_9a9c_1a33468b5757
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8TEQ8
name: PIGO
is encoded by: hsa:84720
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_08bc5b12_8cba_44f8_97c2_1ed3383d1fb5
is: Q7LBE3
initial concentration: NaN
is encoded by: hsa:115019
boundary condition: true
name: SLC26A9
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaR HESTRATRIOLtr
type: Reaction
name: hydroxylated estrogen derivative transport
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaM 10fthf e
is: CHEBI:57454
is: SBO:0000247
is: HMDB00972
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
type: Species
constant: false

metaM 56dthm c
initial concentration: 1.0
is: HMDB00079
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
type: Species
has only substance units: false
constant: false
is: CHEBI:27468
is: SBO:0000247
name: 5,6-dihydrothymine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_5ed32f05_e2b8_4bab_924e_02b71bf914ec
is encoded by: hsa:65263
initial amount: NaN
is: Q53H96
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PYCRL
constant: false

metaR GACPAILter
kinetic law: MODEL1310110016#
reversible: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_392c8c7f_e675_4c02_8af3_4183efa7cc4c
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACAT1
is encoded by: hsa:38
is: P24752
initial amount: NaN
constant: false

metaR r1890
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110016#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM ksi deg28 l
is: HMDB00812
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
initial concentration: 1.0
constant: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
name: keratan sulfate I, degradation product 28
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_64dffe3b_27bf_46ee_9af9_5742e41c4176
is encoded by: hsa:51809
type: Species
constant: false
is: Q86SF2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GALNT7

metaR r0434
fast: false
reversible: true
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000

metaR r0587
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
product: MODEL1310110016#

metaR FAOXC201C181x
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_be18d10b_c34e_4cb0_a2a9_3466c89c0931
is encoded by: hsa:51102
is: Q9BV79
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: MECR
constant: false
is: SBO:0000252
has only substance units: false

metaM ascb L e
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
is: HMDB00044
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: L-ascorbate

metaR PROSTGF2t
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
reactant: MODEL1310110016#
reversible: true
type: Reaction
name: prostaglandin uniport
product: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR GLNtm
is described by: ECO:0000000
name: L-glutamine transport via electroneutral transporter
reactant: MODEL1310110016#
type: Reaction
fast: false
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
product: MODEL1310110016#

metaR MI14Ptn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
type: Reaction
fast: false
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#

metaM udp c
initial amount: NaN
is: CHEBI:58223
is: HMDB00295
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
boundary condition: false
initial concentration: 1.0
name: UDP
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a57592fb_8cb5_49e7_b608_7557546bd59d
initial concentration: NaN
has only substance units: false
boundary condition: true
name: UPP1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:7378
is: SBO:0000252

metaR r1891
is described by: ECO:0000000
modifier: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110016#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_817371e3_112e_4e45_8f4d_c819aed174ce
initial concentration: NaN
constant: false
type: Species
name: NDUFB1
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O75438
initial amount: NaN
is encoded by: hsa:4707

metaM anth e
is: HMDB01123
is: CHEBI:16567
constant: false
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
name: anthranilate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_596786d7_04b5_4867_9ed0_480febc42458
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:353
initial amount: NaN
initial concentration: NaN
name: APRT
has only substance units: false
is: P07741
constant: false

metaR GSNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
name: guanosine facilated transport in cytosol
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110016#
is described by: ECO:0000269

metaM pglyc hs c
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CHARGE: 0
type: Species
has only substance units: false
name: pglyc_hs[c]
is: CHEBI:21338
is: HMDB02704
is: SBO:0000247

metaM udpacgal c
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: HMDB00304
constant: false
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57847
type: Species

metaM 10fthf c
type: Species
initial amount: NaN
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00972
initial concentration: 1.0
is: C00234
boundary condition: false
name: 10-Formyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110016#_fd523be6_7615_411c_8c7e_b293adfe7588
boundary condition: true
name: CA5A
is: P35218
type: Species
has only substance units: false
is encoded by: hsa:763
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1538
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
reactant: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000

metaM xylu D c
is: CHEBI:17140
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
boundary condition: false
name: D-xylulose
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB01644
has only substance units: false

metaM btn m
is: HMDB00030
has only substance units: false
boundary condition: false
is: CHEBI:57586
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
is: SBO:0000247
constant: false
name: biotinate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_5028c7ce_bf0a_4ec2_b3c5_5937b89b14f7
is encoded by: hsa:5335
initial amount: NaN
boundary condition: true
has only substance units: false
name: PLCG1
constant: false
type: Species
is: Q9UFY1
initial concentration: NaN
is: SBO:0000252

metaR DM atp c
is: SBO:0000176
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: DM_atp(c)

metaM hspg l
boundary condition: false
name: heparan sulfate proteoglycan
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01993
constant: false
type: Species
initial amount: NaN
is: CHEBI:17899
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110016#_8eb45819_05ad_4338_950f_90e474ca907f
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8833
type: Species
is: SBO:0000252
constant: false
is: P49915
name: GMPS
initial amount: NaN

metaR ANTHte
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110016#
type: Reaction
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: true
name: Transport of anthranilate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR GGLUCT
name: gamma-glutamylcyclotransferase
is: SBO:0000185
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
product: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.2.4

metaR 3AIBt
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
name: 3-amino-isobutyrate transport
is: SBO:0000185
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT

metaR RE1532M
product: MODEL1310110016#
name: RE1532
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110016#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_3cef2d60_1679_47d8_ac9e_9d8ba910fbd1
is encoded by: hsa:1350
name: COX7C
initial amount: NaN
constant: false
is: P15954
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM drib c
is: CHEBI:28816
constant: false
is: HMDB03224
has only substance units: false
type: Species
name: 2-deoxy-D-ribose
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
boundary condition: false

metaR DHFtm
fast: false
name: dihydrofolate reversible mitochondrial transport
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_b6590835_5916_4fd9_b7e8_de9367438a74
initial amount: NaN
constant: false
is encoded by: hsa:55229
is: SBO:0000252
has only substance units: false
type: Species
name: PANK4
boundary condition: true
initial concentration: NaN
is: Q9NVE7

metaM udp e
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
constant: false
name: UDP(3-)
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
is: HMDB00295

metaR RE2799C
is described by: ECO:0000000
name: RE2799
kinetic law: MODEL1310110016#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
fast: false

metaR S6TASE14ly
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_0644b844_09db_45ff_8517_893ccb42cadb
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1716
name: DGUOK
initial amount: NaN
constant: false
initial concentration: NaN
is: E5KSL6
type: Species

metaR PROt2r
modifier: MODEL1310110016#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000304
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: L-proline reversible transport via proton symport
product: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_51eec744_80ea_45ff_876f_9bd82b02205f
boundary condition: true
name: DGKQ
is encoded by: hsa:1609
initial amount: NaN
type: Species
is: P52824
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

metaM hs deg7 l
type: Species
initial amount: NaN
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB06254

metaR r2420
reactant: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110016#
is: SBO:0000185

metaM 3pg m
constant: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58272
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197

http://identifiers.org/biomodels.db/MODEL1310110016#_bc6d6858_0431_4036_b915_66cc84803390
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q13011
constant: false
is encoded by: hsa:1891
name: ECH1
is: SBO:0000252

metaR It
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
name: Iodide uniport
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110016#
fast: false
reversible: true

metaM 3otdcoa m
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
initial concentration: 1.0
is: CHEBI:28726
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03935
name: 3-Oxotetradecanoyl-CoA

metaM ascb L c
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
is: HMDB00044
name: L-ascorbate
type: Species
is: CHEBI:38290
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_51045ea8_f660_4355_b9b6_4e710bd50a4a
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:125965
constant: false
is: SBO:0000252
type: Species
is: Q6YFQ2
initial amount: NaN
name: COX6B2

metaR ATP1ter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
name: ADP/ATP transporter, endoplasmic reticulum

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR KYNAKGAT
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110016#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: L-Kynurenine:2-oxoglutarate aminotransferase

metaM sphings c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
is: HMDB00252
is: CHEBI:57756
boundary condition: false
constant: false
is: SBO:0000247
name: sphingosine(1+)

metaR r0377
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110016#

metaM dump c
boundary condition: false
type: Species
is: HMDB01409
is: SBO:0000247
name: dUMP
is: CHEBI:246422
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00365

metaM pydam c
is: C00534
initial concentration: 1.0
initial amount: NaN
name: Pyridoxamine
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: HMDB01431
constant: false
is: CHEBI:57761
is: SBO:0000247

metaR SADT
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
name: sulfate adenylyltransferase
reversible: false
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
is described by: ECO:0000269

metaM trdrd m
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15967
initial amount: NaN
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_cfb33761_01e1_492c_9985_80a730b8445e
is encoded by: hsa:28232
has only substance units: false
constant: false
is: Q9UIG8
name: SLCO3A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM f1a l
name: F1alpha
initial amount: NaN
initial concentration: 1.0
is: HMDB02917
constant: false
has only substance units: false
is: CHEBI:17151
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_bc12e181_82c1_4b69_baad_08f0cdad8b48
is encoded by: hsa:276
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: P04745
has only substance units: false
name: AMY1A
boundary condition: true
constant: false

metaM melatn c
is: HMDB01389
initial concentration: 1.0
has only substance units: false
name: melatonin
is: CHEBI:16796
constant: false
type: Species
boundary condition: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
is: SBO:0000247
initial amount: NaN

metaM CE5586 c
boundary condition: false
initial concentration: 1.0
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
constant: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
type: Species
is: CHEBI:58732
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8b8bd85a_6cfe_4c0d_8842_383df5bef939
name: _H17063_1_m
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:H17063
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_5e5a8c2f_878a_42c8_b0d2_acd55c64e948
is: O75964
initial concentration: NaN
name: ATP5L
type: Species
is encoded by: hsa:10632
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR RE2069C
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
name: RE2069
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
fast: false

metaR UMPK2
name: UMP kinase (CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
fast: false
product: MODEL1310110016#
is described by: ECO:0000269

metaR FBA
type: Reaction
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
product: MODEL1310110016#
name: fructose-bisphosphate aldolase
is: SBO:0000176
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13

metaR r0994
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: true

metaM lnlnca l
is: HMDB01388
is: CHEBI:32387
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: alpha-linolenate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_f6d0edb4_803c_4b45_9b38_2775c1204f10
is encoded by: hsa:8560
boundary condition: true
initial amount: NaN
name: DEGS1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR RE1796R
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
modifier: MODEL1310110016#
fast: false
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110016#

metaM acnam l
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
constant: false
has only substance units: false
boundary condition: false
name: N-acetylneuraminate
type: Species
is: CHEBI:35418
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_deb80f47_e027_4421_83d3_51dada79563c
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095
initial concentration: NaN
type: Species
name: _AI222095_1_e
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_baac2a3a_fad1_4f71_82cf_a74381f7b414
is encoded by: hsa:6576
has only substance units: false
is: D9HTE9
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC25A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_c18ddb70_17e8_4cef_ba78_6f1785040d5d
initial amount: NaN
is encoded by: hsa:8527
constant: false
has only substance units: false
is: Q16760
type: Species
name: DGKD
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_b8726b70_5962_4003_b7db_8ed338d7ebc5
name: PIGF
is encoded by: hsa:5281
boundary condition: true
is: Q6IB04
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaM HC00250 e
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
is: CHEBI:29919
initial concentration: 1.0
name: hydrosulfide

metaR NACHEX20ly
modifier: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110016#
reactant: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110016#_dc9afca4_2fed_435d_aee6_959e9f53d1c5
initial amount: NaN
name: KHK
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3795
initial concentration: NaN
is: P50053
is: SBO:0000252

metaR FRDPtcr
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d7929f9d_0010_4a55_af7d_8aec043c8997
name: ENO3
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2027
has only substance units: false
type: Species
is: D3DTL2

metaM mal L m
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15589
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
is: SBO:0000247
name: (S)-malate(2-)

metaR GLCNACASE2ly
modifier: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false

metaR FUMSO3tm
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110016#
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110016#

metaR ACONTm
reactant: MODEL1310110016#
is: SBO:0000176
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Aconitate hydratase
modifier: MODEL1310110016#
type: Reaction
product: MODEL1310110016#

metaM ile L e
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00172
has only substance units: false
name: L-isoleucine
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110016#_35fd5cd2_36a3_4025_8a0b_38999d57cfd4
is encoded by: hsa:2629
is: SBO:0000252
is: B7Z6S1
constant: false
initial amount: NaN
name: GBA
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_6508de6f_f637_4453_993d_da64c2cc8ea2
has only substance units: false
is: P06865
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3073
boundary condition: true
name: HEXA

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_085fd241_648d_4901_b54e_c501106262d2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:BG035985
has only substance units: false
initial concentration: NaN
name: _BG035985_1_c

metaR r0911
name: Facilitated diffusion
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR MALTSULtm
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110016#
type: Reaction
is: SBO:0000185
reversible: true
name: Malate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaM HC01231 m
is: CHEBI:58480
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_f4661530_0351_4d0f_8dd2_27b7b5a7e2b1
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: SLC29A1
initial amount: NaN
is: Q99808
is: SBO:0000252
is encoded by: hsa:2030

metaM ksi deg26 l
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:58343
is: HMDB00061
boundary condition: false
name: keratan sulfate I, degradation product 26
initial concentration: 1.0
notes: FORMULA: C110H179N7O93S4 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110016#_a23fac7f_888a_4fb7_8053_cad17c46d067
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: LDHB
type: Species
initial amount: NaN
is: P07195
is encoded by: hsa:3945
has only substance units: false

metaR UMPK4
is: SBO:0000176
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
name: UMP kinase (GTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
product: MODEL1310110016#

metaR RE2649M
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
modifier: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
type: Reaction
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE2649

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110016#
name: Gamma-glutamyltransferase
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_4f61fd73_d6b6_4e80_bf8d_49fae5dd871e
is: Q9H2U2
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PPA2
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27068

metaR GLUtr
is described by: ECO:0000000
name: intracellular transport
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00224
type: Species
is: CHEBI:58190
is: SBO:0000247
constant: false
name: ethamp[c]
initial amount: NaN

metaR ARAB Lt
product: MODEL1310110016#
fast: false
reversible: true
name: L-arabinoase extracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR CSNATm
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-aceyltransferase, mitochondrial
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
type: Reaction
modifier: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
fast: false
is: SBO:0000176
product: MODEL1310110016#

metaR GMPR
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.7.1.7
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
product: MODEL1310110016#
name: GMP reductase
reversible: false
kinetic law: MODEL1310110016#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM HC00250 c
is: CHEBI:29919
constant: false
has only substance units: false
is: SBO:0000247
name: hydrosulfide
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaM ksii core2 deg5 l
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:12936
constant: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_a7f61ca8_dc5e_427d_ba45_f0af8e641094
has only substance units: false
name: NME7
is encoded by: hsa:29922
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9Y5B8
is: SBO:0000252
boundary condition: true
constant: false

metaR DM anth
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR UMPK3
modifier: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
type: Reaction
name: UMP kinase (UTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0995
type: Reaction
fast: false
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
product: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000

metaM ile L c
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00172
name: L-isoleucine
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191

metaM 5thf e
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06487
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
name: pentaglutamyl folate (THF)

metaM pd3 c
name: Previtamin D3
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
is: HMDB06500
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_77d96e64_6e8a_429a_aacb_b769f500beb2
has only substance units: false
is encoded by: hsa:H17063
type: Species
name: _H17063_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM dolp U r
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57683
initial concentration: 1.0
name: dolichyl phosphate(2-)
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

http://identifiers.org/biomodels.db/MODEL1310110016#_90950f3f_4789_4f52_b384_1502b83c8d0c
constant: false
name: SLC4A2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6522
type: Species
is: F8W682
has only substance units: false
initial amount: NaN
boundary condition: true

metaR PLA2 2
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ

metaR FE2t
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
reversible: false
type: Reaction
name: iron (II) transport
fast: false

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR DAGt
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110016#
name: diacylglycerol transport
product: MODEL1310110016#
reversible: true
fast: false

metaR r0913
reactant: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_39882216_a907_4578_9724_0e33595d2388
boundary condition: true
is: O14975
name: SLC27A2
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:11001
type: Species

metaR CSNATp
fast: false
reversible: true
type: Reaction
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
is: SBO:0000176
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110016#
modifier: MODEL1310110016#

metaR r0580
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#

metaR RE1448N
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: RE1448
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_fabaee02_51d0_4875_8f4c_4ebeb19cb4a2
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has only substance units: false
has part: Q6FIH7
boundary condition: true
type: Species
is encoded by: hsa:516
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_03950213_ea1d_4012_9c9e_cfc78420fea8
constant: false
is encoded by: hsa:3939
name: LDHA
is: P00338
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR OLEICFATPtc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a8bc4cbf_0a67_40e6_b637_979c32616bc5
type: Species
is: Q96E98
has only substance units: false
constant: false
boundary condition: true
name: RHAG
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6005
is: SBO:0000252

metaR UMPK6
is described by: ECO:0000269
reactant: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dCTP)

metaM ksi deg19 l
boundary condition: false
name: keratan sulfate I, degradation product 19
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
initial concentration: 1.0
is: CHEBI:16953
is: HMDB00812
initial amount: NaN

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR RE3001M
is: SBO:0000176
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.34
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
name: RE3001
modifier: MODEL1310110016#

metaR GALASE7ly
modifier: MODEL1310110016#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110016#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM dem2emgacpail prot hs r
is: SBO:0000247
constant: false
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
is: HMDB03537
initial concentration: 1.0
is: CHEBI:61382
has only substance units: false
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_e2d2558e_96ba_44ab_b9c4_8365f41e572a
is: SBO:0000252
type: Species
is encoded by: hsa:4714
has only substance units: false
name: NDUFB8
constant: false
boundary condition: true
is: O95169
initial amount: NaN
initial concentration: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR THMDt5le
name: thymidine transport (1:2 Na/Thymd cotransport)
reversible: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110016#_0baed313_b020_4580_895e_63999708596c
is encoded by: hsa:93034
is: SBO:0000252
is: B3KUK6
constant: false
name: NT5C1B
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaR r0990
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110016#

metaR r0669
product: MODEL1310110016#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reversible: false
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110016#_5c844f29_f3ee_460b_89f1_a5d77c4c26f3
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5320
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: P14555
name: PLA2G2A

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM prpp c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
has only substance units: false
is: HMDB00280
is: C00119
is: CHEBI:58017
constant: false
initial concentration: 1.0
type: Species

metaM CE5854 e
is: HMDB02710
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:27485
is: SBO:0000247
initial concentration: 1.0
type: Species
name: gama-CEHC-glucuronide
initial amount: NaN
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854

http://identifiers.org/biomodels.db/MODEL1310110016#_233358d8_200f_41e2_a8cc_f0f7b558e9ae
initial concentration: NaN
boundary condition: true
name: ACAA2
type: Species
is: SBO:0000252
is: P42765
is encoded by: hsa:10449
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c7d321ef_381f_4d75_8242_ec61ae481d00
is: Q9BZX2
constant: false
initial amount: NaN
is encoded by: hsa:7371
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: UCK2

metaR RE1796M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
reversible: true
name: RE1796
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR ME1m
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.38
reactant: MODEL1310110016#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
name: malic enzyme (NAD), mitochondrial

metaR UMPK5
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
name: UMP kinase (dATP)

metaM 2dr1p c
is: SBO:0000247
is: HMDB01351
name: 2-Deoxy-D-ribose 1-phosphate
is: CHEBI:58576
boundary condition: false
constant: false
is: C00672
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
has only substance units: false
type: Species

metaM f1a g
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:17151
is: HMDB02917
name: F1alpha
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaM retinol 9 cis c
initial concentration: 1.0
constant: false
name: 9-cis-retinol
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
type: Species
is: CHEBI:17336
is: HMDB06217
initial amount: NaN
has only substance units: false

metaR CORE5GTg
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
name: Core 5 alpha-GalNAc-transferase, Golgi apparatus
kinetic law: MODEL1310110016#
fast: false
type: Reaction

metaR OROTGLUt
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: OROTGLUt
fast: false
type: Reaction
product: MODEL1310110016#
is: SBO:0000185

metaR PAIL HStn
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_56fc6783_f497_4c07_b77a_9060105bc5cd
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: BDH1
is encoded by: hsa:622
initial concentration: NaN
is: Q02338
initial amount: NaN
has only substance units: false

metaM ksi deg15 l
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 15
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: CHEBI:12936
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110016#_ee4c6643_78cb_4d82_9150_497857d52f71
type: Species
boundary condition: true
name: STARD3
is: SBO:0000252
is encoded by: hsa:10948
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: B4DUY1

metaR r2202
reactant: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true

metaR r0915
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110016#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110016#
fast: false

metaR EX 34hpp
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR GALASE11ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110016#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
modifier: MODEL1310110016#

metaR CSNATr
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
type: Reaction
product: MODEL1310110016#
name: carnitine O-acetyltransferase
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM pmtcrn x
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: L-palmitoylcarnitine
type: Species
is: HMDB00222
is: CHEBI:17490
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false

metaR r0666
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
product: MODEL1310110016#
type: Reaction
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.4.2

http://identifiers.org/biomodels.db/MODEL1310110016#_bed461f3_8fe4_4df9_b010_e93a51cb64eb
has only substance units: false
constant: false
is: SBO:0000252
name: _AA081045_1_e
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA081045
initial concentration: NaN

metaM hdca c
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
name: palmitate
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:7896
initial concentration: 1.0
is: HMDB00220
constant: false

metaM mal L e
initial concentration: 1.0
type: Species
name: (S)-malate(2-)
is: HMDB00156
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaR PETHCT
name: phosphoethanolamine cytidyltransferase
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.14

metaM acnam n
is: CHEBI:35418
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
has only substance units: false
name: N-acetylneuraminate

metaR UMPK5n
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110016#

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r1106
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110016#
name: Postulated transport reaction
type: Reaction
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is: SBO:0000185

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
constant: false
has only substance units: false
boundary condition: false
is: HMDB00305
initial amount: NaN
is: SBO:0000247
name: retinol
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_eb9cddae_2730_4d6d_97d1_d19bf50e1499
boundary condition: true
name: ATP1B4:ATP1A2
initial concentration: NaN
has part: Q9UN42
has part: P50993
is: SBO:0000297
constant: false
has only substance units: false
is encoded by: hsa:23439
initial amount: NaN
is encoded by: hsa:477
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_530bd91b_1f46_427f_8c97_2c5ba67fa419
is: Q6LEN5
name: CHAT
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1103
is: SBO:0000252

metaM prpp e
constant: false
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0
boundary condition: false

metaR CHAT
is described by: ECO:0000269
kinetic law: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110016#
name: Choline O-acetyltransferase
reversible: true
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
type: Reaction

metaM pnto R e
name: (R)-Pantothenate
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00210
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916

metaR BTNtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
reversible: true
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
name: Biotin transport, nuclear

metaR MDHm
name: malate dehydrogenase, mitochondrial
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
kinetic law: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37

metaR UMPK7
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: UMP kinase (dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM lnlnca e
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
name: alpha-linolenate
is: SBO:0000247
boundary condition: false
is: CHEBI:32387
initial amount: NaN
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110016#_f17532f8_5544_4ec2_b117_25d35ce577fc
has only substance units: false
is encoded by: hsa:10637
is: SBO:0000252
initial concentration: NaN
is: O75610
name: LEFTY1
initial amount: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_d1e85d66_f613_4866_b2fb_31241c59f09b
name: SLC40A1
initial amount: NaN
constant: false
type: Species
is: Q9NP59
is encoded by: hsa:30061
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_b711acca_77db_4e88_881c_8f9014634735
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI620219
initial concentration: NaN
type: Species
name: _AI620219_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_15bee0e4_dfd6_4a56_bb1e_f1d57a58d7da
type: Species
is: P42126
constant: false
is: SBO:0000252
name: ECI1
initial amount: NaN
boundary condition: true
is encoded by: hsa:1632
initial concentration: NaN
has only substance units: false

metaM udpglcur r
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58052
type: Species
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
name: UDP-D-glucuronate
boundary condition: false
is: C00167
has only substance units: false
is: SBO:0000247

metaR CYTK8n
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110016#
type: Reaction
name: cytidylate kinase (CMP,dATP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_9b1891c5_a9cb_40bc_ba41_1939560725d7
is: Q9HBH5
is: SBO:0000252
is encoded by: hsa:57665
has only substance units: false
type: Species
initial concentration: NaN
name: RDH14
constant: false
initial amount: NaN
boundary condition: true

metaM hdca e
is: C00249
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
is: CHEBI:0
is: HMDB00220

metaM mal L c
is: HMDB00156
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
name: (S)-malate(2-)
is: CHEBI:15589
is: SBO:0000247
has only substance units: false
constant: false

metaM ump c
has only substance units: false
type: Species
name: UMP
is: CHEBI:57865
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
is: SBO:0000247
boundary condition: false
is: HMDB00288
initial amount: NaN

metaR TRIODTHYt2
name: T3 transport via facilitated diffusion
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110016#_41eaa91c_bab2_4449_9d5e_d4968bbf2fa7
boundary condition: true
is encoded by: hsa:1593
initial concentration: NaN
constant: false
initial amount: NaN
is: Q02318
has only substance units: false
type: Species
is: SBO:0000252
name: CYP27A1

http://identifiers.org/biomodels.db/MODEL1310110016#_c891be60_9c00_453a_9001_ef15d0061b41
is: SBO:0000252
is encoded by: hsa:80308
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: Q8NFF5
has only substance units: false
name: FLAD1

metaR ADSL1
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
name: adenylosuccinate lyase
is: SBO:0000176
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_e8ef03d1_80f4_4557_8760_76f06ac2aa66
has only substance units: false
boundary condition: true
constant: false
is: P04746
initial concentration: NaN
initial amount: NaN
type: Species
name: AMY2A
is: SBO:0000252
is encoded by: hsa:279

metaM udpglcur c
boundary condition: false
constant: false
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
name: UDP-D-glucuronate
initial amount: NaN
is: C00167
is: CHEBI:58052
initial concentration: 1.0
is: SBO:0000247
is: HMDB00935

metaM hmgcoa x
type: Species
constant: false
is: HMDB01375
is: CHEBI:15467
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA

metaR CHSTEROLt2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: cholesterol intracellular transport
fast: false
product: MODEL1310110016#
type: Reaction

metaM CE2422 m
is: HMDB11123
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

metaR r2067
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185

metaM ksii core2 deg8 l
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
type: Species
constant: false
has only substance units: false
is: CHEBI:12936
boundary condition: false
is: HMDB00143
initial concentration: 1.0

metaR ASNtm
product: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
name: L-asparagine transport, mitochondrial
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_60deadd8_5a25_4e95_a9d2_f7e76984ec4c
initial concentration: NaN
name: BTD
is encoded by: hsa:686
constant: false
type: Species
is: P43251
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM hs deg16 l
has only substance units: false
boundary condition: false
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
is: HMDB02704
is: CHEBI:21338
name: heparan sulfate, degradation product 16
initial amount: NaN
type: Species
constant: false

metaR HDCEAtr
fast: false
type: Reaction
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_73ac2515_aed5_41d2_9e95_448660ce28ae
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM ile L m
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
type: Species
initial concentration: 1.0
is: HMDB00172
is: CHEBI:17191

metaM 3pg c
name: 3-Phospho-D-glycerate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58272
is: C00197
initial concentration: 1.0
is: HMDB00807

metaM lnlncgcoa r
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
type: Species
is: HMDB06368
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57363
initial concentration: 1.0
has only substance units: false

metaM mag hs e
has only substance units: false
is: SBO:0000247
is: CHEBI:60479
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
type: Species

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:7916
initial amount: NaN
name: (R)-Pantothenate

metaR RE2660N
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE2660
reversible: true

metaR RE2649C
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#
reversible: true
is: SBO:0000176

metaR r0157
fast: false
reversible: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#

metaR GLNtN1
name: Glutamine transport (Na, H coupled)
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
type: Reaction
product: MODEL1310110016#
reversible: true
is: SBO:0000185
modifier: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

http://identifiers.org/biomodels.db/MODEL1310110016#_35261287_0a56_4c43_8bfd_ced7130fe653
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC26A7
type: Species
initial concentration: NaN
is: Q8TE54
is encoded by: hsa:115111
constant: false
boundary condition: true

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR CHSTEROLt3
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110016#
type: Reaction
name: cholesterol intracellular transport
fast: false

metaM sphings l
has only substance units: false
is: CHEBI:57756
name: sphingosine(1+)
constant: false
boundary condition: false
is: HMDB00252
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
is: SBO:0000247

metaR RE3346C
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
type: Reaction
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM ump e
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
constant: false
is: SBO:0000247
name: UMP(2-)
initial concentration: 1.0
is: HMDB00288
boundary condition: false
initial amount: NaN

metaR ALAt2r
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000304
modifier: MODEL1310110016#
type: Reaction
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
fast: false
name: L-alanine reversible transport via proton symport

metaR r1109
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is: SBO:0000176
reactant: MODEL1310110016#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
product: MODEL1310110016#
reversible: true
is described by: ECO:0000000
fast: false

metaM trdrd c
is: CHEBI:15967
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: Reduced thioredoxin
initial concentration: 1.0

metaM trdox m
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110016#_f9bed56d_3e75_4987_9c8d_eb5b8e6e5c90
is encoded by: hsa:226
boundary condition: true
name: ALDOA
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR DASCBR
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is version of: http://identifiers.org/ec-code/1.8.4.1
fast: false
kinetic law: MODEL1310110016#
name: dehydroascorbate reductase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_3125348a_dc58_48a0_be05_497acc70279c
name: _AU149534_1_e
is encoded by: hsa:AU149534
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_37bdcb5b_de07_44da_a36f_efd0c0c4d8cc
is: SBO:0000252
is encoded by: hsa:8560
constant: false
name: DEGS1
is: O15121
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM pydx c
has only substance units: false
constant: false
is: HMDB01545
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17310
is: C00250
initial concentration: 1.0
name: Pyridoxal
boundary condition: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250

metaM HC01603 c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
boundary condition: false
is: C00234
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
constant: false
has only substance units: false
type: Species

metaM ksi deg37 l
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16953
name: keratan sulfate I, degradation product 37
is: SBO:0000247
boundary condition: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
type: Species
constant: false
is: HMDB00812

metaR ASNS1
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
name: asparagine synthase (glutamine-hydrolysing)
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.3.5.4
fast: false
is: SBO:0000176

metaR r2065
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
reversible: false
type: Reaction

metaM HC01501 c
name: hydroxidodioxidosulfidosulfate(1-)
type: Species
has only substance units: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:33539
initial concentration: 1.0
boundary condition: false

metaR FAS160COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110016#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
fast: false
product: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269

metaR IDOURtly
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false
name: iduronate transport into lysososme
is described by: ECO:0000269
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD

http://identifiers.org/biomodels.db/MODEL1310110016#_bbbbde1b_53c6_4a04_a2e6_971701badd28
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6120
constant: false
initial amount: NaN
has only substance units: false
is: Q53TV9
name: RPE
boundary condition: true
type: Species

metaM 10fthf6glu e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:57454
has only substance units: false
constant: false
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110016#_21b55ebc_caf4_410d_a3f1_528521420c73
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P54868
is encoded by: hsa:3158
is: SBO:0000252
initial concentration: NaN
name: HMGCS2
initial amount: NaN

metaM mag hs c
constant: false
initial concentration: 1.0
is: HMDB12130
is: SBO:0000247
initial amount: NaN
name: monoacylglycerol 2
boundary condition: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: CHEBI:16987

metaR LTC4CP
reactant: MODEL1310110016#
fast: false
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_e625b4a4_195d_46a2_b572_a2f5ab833000
type: Species
constant: false
is encoded by: hsa:23475
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: QPRT
is: Q15274

metaR HS3ly
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_cdf336eb_a78d_494d_9de4_dacd6585f531
name: ST6GALNAC5
initial amount: NaN
is: Q9BVH7
constant: false
boundary condition: true
is encoded by: hsa:81849
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM chol n
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
constant: false
has only substance units: false
is: CHEBI:15354
initial concentration: 1.0
is: SBO:0000247
name: choline
is: HMDB00097
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e66a4b82_58e6_4353_a628_207622761dcc
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8776
has only substance units: false
is: Q13613
is: SBO:0000252
initial amount: NaN
name: MTMR1

metaR S6TASE1ly
reactant: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110016#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM ksi deg39 l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
has only substance units: false
notes: FORMULA: C48H81N3O36 CHARGE: 0
boundary condition: false
name: keratan sulfate I, degradation product 39
initial amount: NaN
constant: false
type: Species

metaM lnlnca r
is: SBO:0000247
is: CHEBI:32387
is: HMDB01388
name: alpha-linolenate
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM trp L e
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
is: CHEBI:16828
is: HMDB00929
initial concentration: 1.0
boundary condition: false
type: Species
name: L-tryptophan
constant: false
initial amount: NaN

metaR LTD4DP
type: Reaction
product: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110016#
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_f9f45a12_676d_481c_bb20_b12cf1f78ff2
is: Q5QPH3
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:55902
initial amount: NaN
name: ACSS2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_0a99744c_4520_484a_8007_f6f3478e7ec6
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6718
is: SBO:0000252
has only substance units: false
name: AKR1D1
type: Species
is: P51857
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_33011cd2_f238_4048_9acd_a34f37356770
is: B4DUG1
is encoded by: hsa:9187
initial amount: NaN
type: Species
name: SLC24A1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM bhb e
name: (R)-3-hydroxybutyrate
is: SBO:0000247
type: Species
is: HMDB00011
initial concentration: 1.0
has only substance units: false
is: CHEBI:10983
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
constant: false

metaR r0660
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110016#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1f1acac7_6735_4392_924c_52e2a893720f
constant: false
type: Species
is: Q8N0W3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:197258
name: FUK
boundary condition: true
has only substance units: false

metaR r0885
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: true

metaM 10fthf7glu e
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
is: CHEBI:57454
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
boundary condition: false
is: HMDB00972

metaM HC01104 e
has only substance units: false
is: CHEBI:61146
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
is: SBO:0000247
constant: false

metaR ORNt4m
is described by: ECO:0000269
type: Reaction
product: MODEL1310110016#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110016#
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110016#
modifier: MODEL1310110016#

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
constant: false
has only substance units: false
is: CHEBI:15893
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: C03912
initial concentration: 1.0
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912

metaR NACHEX22ly
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110016#_00f95824_1d87_4f3a_9410_3bfe4411b98c
is: SBO:0000252
is encoded by: hsa:22934
type: Species
name: RPIA
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P49247

metaM chol m
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
name: choline
has only substance units: false
is: CHEBI:15354
initial amount: NaN
boundary condition: false

metaR GALASE16ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false

metaR DCYTt
name: deoxycytidine transport via diffusion
kinetic law: MODEL1310110016#
is: SBO:0000185
reversible: true
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR PAN4PPe
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
name: PAN4PPe
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

metaR DURItn
type: Reaction
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
name: deoxyuridine transport in nucleus
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_1f7e2894_3853_4261_9cdb_7e1a594bc8fa
is: SBO:0000252
constant: false
is encoded by: hsa:4830
initial amount: NaN
name: NME1
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaR ASP1DC
notes: GENE_ASSOCIATION: (2571.1) or (2571.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.1.1.15 Confidence Level: 1 AUTHORS: NOTES:The E. coli enzyme contains a pyruvoyl group.
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: false
product: MODEL1310110016#
reactant: MODEL1310110016#
name: aspartate 1-decarboxylase

http://identifiers.org/biomodels.db/MODEL1310110016#_526a25e1_627a_4200_a4b2_0da04739acce
boundary condition: true
is: P43004
constant: false
is encoded by: hsa:6506
name: SLC1A2
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR GLYGLYPEPT1tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycyl-glycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ea391e96_f8dc_47f5_8648_72e2f15273be
boundary condition: true
has only substance units: false
name: AQP8
initial amount: NaN
is: SBO:0000252
is: O94778
is encoded by: hsa:343
constant: false
initial concentration: NaN
type: Species

metaR r0774
reversible: true
kinetic law: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110016#
modifier: MODEL1310110016#

metaR S6TASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110016#_393cbceb_24de_426c_bf42_9ef792ba017e
constant: false
is: Q9GZR5
name: ELOVL4
is encoded by: hsa:6785
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r2310
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110016#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
fast: false
product: MODEL1310110016#

metaR 4HGLSDm
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
fast: false
is described by: ECO:0000212
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true

metaR r0801
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
fast: false
product: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110016#_6e4391c0_d1e9_4dea_9f18_4158dc46791f
has only substance units: false
name: C1GALT1
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9NS00
is encoded by: hsa:56913
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_ac5988ea_a9d6_44c6_b8fc_e48c5eaaa8c3
initial concentration: NaN
name: ATP5E
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:514
constant: false

metaR H2MTer U
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
product: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
name: H2 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110016#

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: beta-galactosidase, lysosomal
fast: false
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_e28534ac_4253_4f73_a101_48109530779e
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: NT5C3
initial concentration: NaN
initial amount: NaN
is: Q9H0P0
is encoded by: hsa:51251
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ba5a36d0_a659_496e_8aab_fe851ba5b3a3
initial concentration: NaN
is encoded by: hsa:3030
is: E9KL44
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: HADHA

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: RE1519
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_4e8790a3_b2cc_4e78_9954_119e97d01833
initial amount: NaN
type: Species
name: LYZL1
constant: false
is: Q6UWQ5
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:84569
initial concentration: NaN

metaM bhb c
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00011
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
name: (R)-3-hydroxybutyrate
boundary condition: false

metaR ASPte
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
is: SBO:0000185
kinetic law: MODEL1310110016#
name: diffusion of aspartate into blood

http://identifiers.org/biomodels.db/MODEL1310110016#_83482d6b_ab51_4a6b_91d9_622f4557b54b
constant: false
initial amount: NaN
name: GMPPA
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:29926

metaM trp L c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16828
boundary condition: false
is: HMDB00929
is: SBO:0000247
type: Species
name: L-tryptophan
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b20ce259_d178_4910_af77_31d31eedb8e7
is: SBO:0000252
is encoded by: hsa:27124
initial amount: NaN
has only substance units: false
constant: false
name: INPP5J
boundary condition: true
initial concentration: NaN
type: Species

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM C05279 m
boundary condition: false
is: HMDB11123
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaM hs deg18 l
initial concentration: 1.0
type: Species
is: HMDB06254
constant: false
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 18
initial amount: NaN
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_4fcd3c0c_6773_40f0_bea1_cf9ed6d8c148
has only substance units: false
constant: false
initial amount: NaN
name: ALDH2
type: Species
is encoded by: hsa:217
is: P05091
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR BMTer U
modifier: MODEL1310110016#
name: B mannosyltransferase, endoplasmic reticulum
reversible: false
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a4de2ced_dd1f_4439_b29d_428b4f2c9f42
initial concentration: NaN
is: SBO:0000252
constant: false
name: GGCT
is encoded by: hsa:79017
boundary condition: true
initial amount: NaN
is: B8ZZR8
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_298a632f_689f_4737_b273_89fcc41ebf9a
is encoded by: hsa:56953
constant: false
is: Q9NPB1
name: NT5M
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM ksi deg31 l
type: Species
name: keratan sulfate I, degradation product 31
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16953
is: HMDB00812
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM didp c
constant: false
name: dIDP
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
boundary condition: false
is: HMDB03536
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_283aaba5_17db_459c_b8a0_8792ad5461de
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q9P2T1
initial amount: NaN
name: GMPR2
is: SBO:0000252
is encoded by: hsa:51292
type: Species

metaR RE0958E
is described by: ECO:0000000
name: RE0958
fast: false
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
product: MODEL1310110016#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110016#_26b94d95_e2ff_43d9_926a_482a39550182
is: SBO:0000252
name: HMGCS2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3158
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: P54868

metaM ksi deg6 l
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
name: keratan sulfate I, degradation product 6
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
is: HMDB00143
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_b2d5bc32_c8cb_4631_bcce_c17a6f049e5d
is: P16152
boundary condition: true
is encoded by: hsa:873
name: CBR1
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e929c556_5b08_4dcb_8cfd_cc034e5bc73f
initial amount: NaN
name: NAGLU
constant: false
initial concentration: NaN
is: P54802
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4669

metaR ARABR
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110016#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
fast: false
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: arabinose reductase
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR RE3050R
fast: false
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE3050
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM imp c
is: C00130
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
constant: false
boundary condition: false
is: HMDB00175
initial concentration: 1.0
name: IMP
type: Species
is: CHEBI:58053

metaR r1259
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reactant: MODEL1310110016#
reversible: false
fast: false
is: SBO:0000176
name: EC:6.2.1.3
product: MODEL1310110016#

metaM xyl D l
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
is: SBO:0000247
has only substance units: false
is: CHEBI:15936
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a727f44a_6ab6_4f13_8e17_75018751e591
constant: false
is: SBO:0000252
name: _206_1_c
type: Species
initial amount: NaN
is encoded by: hsa:206
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM hdca l
initial amount: NaN
is: HMDB00220
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate
is: SBO:0000247
is: CHEBI:7896
constant: false
has only substance units: false

metaR THFtm
fast: false
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_0a11e9ed_6114_49d3_ab9a_f2f17a4f24c5
boundary condition: true
is: SBO:0000252
constant: false
name: GGT1
is: P19440
initial concentration: NaN
type: Species
is encoded by: hsa:2678
initial amount: NaN
has only substance units: false

metaM pail45p hs m
is: CHEBI:28910
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
constant: false
has only substance units: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM 13dpg c
has only substance units: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
initial concentration: 1.0
is: CHEBI:57604
boundary condition: false
is: C00236
is: SBO:0000247
name: 3-Phospho-D-glyceroyl phosphate
constant: false
is: HMDB01270
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaM xol25oh r
is: CHEBI:42977
has only substance units: false
name: 25-hydroxycholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: HMDB06247
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR SPH1Pte
type: Reaction
fast: false
name: sph1p transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaM alaala e
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H12N2O3 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: D-Alanyl-D-alanine

metaR GASNASE3ly
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
name: glycosylasparaginase, lysosomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a6eeff89_76e0_4b67_9a5d_7268938f5c5c
has only substance units: false
is encoded by: hsa:7357
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: UGCG
is: Q16739
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_0dec2801_a718_4b4f_adea_c317bc1344dd
is encoded by: hsa:8898
is: A6NN98
name: MTMR2
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaM xol7aone r
constant: false
has only substance units: false
is: CHEBI:17899
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species

metaR r1566
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_83bd6044_5477_4eac_837d_800c490d1b6f
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6574
is: Q8WUM9
initial concentration: NaN
name: SLC20A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_00d43a67_178e_470d_9830_f436df273fe5
name: PEMT
is: SBO:0000252
is encoded by: hsa:10400
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM glyc R m
name: D-glycerate
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
is: HMDB00139
boundary condition: false
is: CHEBI:16659
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR 5ADTSTSTERONEte
reactant: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_105dcab8_ee14_4b20_b5ba_a60671abfe46
boundary condition: true
is: SBO:0000252
constant: false
name: DHFR
type: Species
is: P00374
initial amount: NaN
is encoded by: hsa:1719
initial concentration: NaN
has only substance units: false

metaM gchola e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate
initial amount: NaN
is: HMDB00138
type: Species
boundary condition: false

metaR H6ET3er
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.1
modifier: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
reversible: false
is: SBO:0000176
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_e80fb0c1_e21e_4b27_8225_d2e4b38dd76d
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q01968
initial amount: NaN
name: OCRL
is encoded by: hsa:4952
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9534ac13_2a4a_4d98_ab68_d68ac737bfe4
is encoded by: hsa:64600
boundary condition: true
initial concentration: NaN
name: PLA2G2F
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: Q9BZM2
has only substance units: false

metaR CHSTEROLt1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: cholesterol intracellular transport
type: Reaction
fast: false
product: MODEL1310110016#
is: SBO:0000185

metaM pail345p hs c
boundary condition: false
constant: false
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
is: CHEBI:57836
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_55fd30cb_1941_4f50_b993_f3da393fdff4
is: Q96IJ6
is encoded by: hsa:29926
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: GMPPA
has only substance units: false
initial amount: NaN
type: Species

metaR GLXtp
name: glyoxylate transport, peroxisomal
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110016#
type: Reaction
fast: false
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#

metaM dhbpt c
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 6,7-dihydrobiopterin
initial concentration: 1.0
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680

http://identifiers.org/biomodels.db/MODEL1310110016#_3b446f9d_81f8_4989_90ad_9bae47dafaae
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:LOC727762
initial concentration: NaN
name: _LOC727762_1_m
boundary condition: true
type: Species

metaM cytd c
is: CHEBI:17562
constant: false
initial amount: NaN
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
type: Species
is: SBO:0000247
is: C00475
is: HMDB00089
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a60afe99_8c66_45cd_b02d_d59ece4751a6
name: SCD
boundary condition: true
type: Species
is: O00767
has only substance units: false
is encoded by: hsa:6319
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_d0db80ef_6b75_4e2c_b164_8f00dd43a3bf
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:51179
type: Species
name: HAO2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_9086d9cd_78c1_44e4_a913_97450106a55a
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6575
name: SLC20A2
is: B2RBR4
initial amount: NaN
constant: false
has only substance units: false

metaR r1923
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reversible: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110016#
product: MODEL1310110016#

metaR r0558
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
modifier: MODEL1310110016#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_6d868b47_bbee_4547_8ab0_f4b596557f6a
is: Q99999
has only substance units: false
is encoded by: hsa:9514
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: GAL3ST1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_e4ee44c3_cbe9_4d65_9129_e3ebe73e37ac
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q92521
name: PIGB
is encoded by: hsa:9488
boundary condition: true
has only substance units: false
constant: false

MODEL1310110016#
species: metaM lys L m
species: metaM amp m
stoichiometry: 0.159671
species: metaM ppi m
type: LocalParameter
species: metaM 7dhchsterol r
species: metaM asp L e
species: metaM pyam5p c
species: metaM mmcoa S m
species: metaM HC02179 c
species: metaM Rtotal l
species: metaM hexde7coa x
species: metaM cmp m
species: metaM co2 m
species: metaM btn e
stoichiometry: 0.009898
species: metaM mi34p c
species: metaM Ser Gly Ala X Gly l
name: ATP1A1:ATP1B2
species: metaM asp D c
species: metaM cholcoa c
species: metaM 3pg m
species: metaM ksii core2 deg6 l
species: metaM acmana e
species: metaM pap c
species: metaM sphs1p e
species: metaM sgalside hs g
species: metaM trdrd c
species: metaM acglcgalgluside hs g
species: metaM itp e
species: metaM so4 l
species: metaM amp x
species: metaM for c
species: metaM gthox c
species: metaM adp r
species: metaM Rtotal3 e
species: metaM akg e
species: metaM o2 n
species: metaM h2o2 x
species: metaM o2s n
species: metaM dpcoa c
species: metaM xylu D c
species: metaM tchola e
species: metaM hom L e
species: metaM mi134p c
species: metaM cmpacna c
species: metaM etha c
species: metaM HC02187 c
species: metaM hs deg21 l
stoichiometry: 0.126406
species: metaM galgluside hs l
species: metaM ksi deg36 l
species: metaM CE0693 m
species: metaM dhf m
species: metaM btn n
species: metaM 3hmp m
species: metaM acgam6p c
species: metaM HC02207 c
species: metaM glcur e
species: metaM fucgalacglcgalgluside hs g
species: metaM dctp n
species: metaM thm c
species: metaM core5 g
species: metaM gdp m
species: metaM dem2emgacpail prot hs r
species: metaM hs deg17 l
species: metaM prostgf2 e
species: metaM glyald c
species: metaM rib D c
species: metaM dcmp n
species: metaM 7dhchsterol c
species: metaM gluside hs r
initial amount: NaN
species: metaM malttr e
species: metaM 12ppd S c
species: metaM HC02149 m
species: metaM acac x
species: metaM nh4 n
species: metaM xolest2 hs c
multipler: 1.0

metaM lpchol hs c
is: SBO:0000247
is: CHEBI:60479
name: lysophosphatidylcholine
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
constant: false
type: Species

metaM fuc L l
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
is: SBO:0000247
type: Species
name: L-fucose
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00174

http://identifiers.org/biomodels.db/MODEL1310110016#_c39ffe1c_3fe4_4056_bfb2_d2a7d868a72f
constant: false
name: PCBD1
boundary condition: true
has only substance units: false
is: P61457
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5092
type: Species
initial concentration: NaN

metaM g1p c
is: C00103
is: SBO:0000247
is: CHEBI:58601
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
constant: false
initial amount: NaN
is: HMDB01586
name: D-Glucose 1-phosphate
initial concentration: 1.0
boundary condition: false

metaM dgtp c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16497
is: C00286
name: dGTP
is: HMDB01440
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR r1565
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM h r
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:24636
is: C00080
constant: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_e16677c3_33cf_43d5_bd3a_57232e1d05b6
is: SBO:0000252
boundary condition: true
constant: false
is: P03915
name: ND5
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4540
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_22d91637_85a9_4e09_a1a3_abf3c5ccabb8
initial concentration: NaN
name: TPK1
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27010
constant: false
type: Species
boundary condition: true
is: F5GZG6

http://identifiers.org/biomodels.db/MODEL1310110016#_0ea0d688_ee43_4356_89c5_02c05d2d9589
is: SBO:0000252
boundary condition: true
name: TM7SF2
type: Species
has only substance units: false
initial amount: NaN
is: O76062
constant: false
initial concentration: NaN
is encoded by: hsa:7108

http://identifiers.org/biomodels.db/MODEL1310110016#_3557074d_ba69_40f6_b7de_53267dfdbcd0
is: P32320
is encoded by: hsa:978
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: CDA

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM hs deg12 l
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06254
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
name: heparan sulfate, degradation product 12

metaR CYSGLTH
reversible: true
kinetic law: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110016#
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM

metaM alaala c
is: SBO:0000247
notes: FORMULA: C6H12N2O3 CHARGE: 0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: D-Alanyl-D-alanine
initial amount: NaN

metaM tststerone r
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:17347
is: SBO:0000247
name: testosterone
is: HMDB00234
boundary condition: false
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535

metaR SPODMm
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
name: superoxide dismutase
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110016#
fast: false

metaM acrn m
constant: false
has only substance units: false
is: HMDB00201
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
is: SBO:0000247
boundary condition: false
type: Species
name: O-acetylcarnitine

metaR r1922
kinetic law: MODEL1310110016#
is: SBO:0000185
modifier: MODEL1310110016#
reactant: MODEL1310110016#
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false

metaR r0559
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110016#
type: Reaction
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_fbd43101_dd58_4340_a599_ac0a2d82d1e2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: P30837
is encoded by: hsa:219
name: ALDH1B1

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR RE0830N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
fast: false
reversible: true
product: MODEL1310110016#
is: SBO:0000176
reactant: MODEL1310110016#
name: RE0830
is described by: ECO:0000000

metaR SPODM
name: superoxide dismutase
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_3d67b5d2_d60b_445d_8415_21ecf7177d3f
is: SBO:0000252
constant: false
is encoded by: hsa:125206
type: Species
is: A0PJK1
boundary condition: true
has only substance units: false
initial amount: NaN
name: SLC5A10
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_16ef0c67_e82f_420e_9859_69271b59fff4
is: P25325
name: MPST
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4357
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a57757e3_f274_4ff4_b22e_f3d16bad71c8
initial concentration: NaN
name: SLC12A7
has only substance units: false
is: Q9Y666
is encoded by: hsa:10723
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM 44mzym r
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
boundary condition: false
is: CHEBI:18364
is: HMDB01286
initial concentration: 1.0
name: 14-demethyllanosterol
type: Species
has only substance units: false
constant: false

metaM memgacpail hs r
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: C05552
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
type: Species
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
constant: false
boundary condition: false
is: HMDB03134
is: SBO:0000247

metaR r1568
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_05713e6e_b6f0_4813_9831_24dd6cf1b86b
is: SBO:0000252
is encoded by: hsa:3295
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: E9PB82
initial amount: NaN
name: HSD17B4
has only substance units: false

metaR DAG HSter
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
name: diacylglycerol ER export

metaR PRAGSr
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.2
fast: false
name: phosphoribosylglycinamide synthase
product: MODEL1310110016#
is described by: ECO:0000269

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR O2Stx
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
name: superoxide anion transport via diffusion (peroxisome)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_d861e5d0_383c_4bfc_a8f9_697f20e6bf2a
constant: false
is encoded by: hsa:3251
name: HPRT1
is: SBO:0000252
boundary condition: true
is: P00492
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR NDPK10n
product: MODEL1310110016#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
is described by: ECO:0000304

metaM pail45p hs n
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28910
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial amount: NaN
is: CHEBI:27466
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_de3cafe6_8341_45a9_9b97_c404e56f7a1e
type: Species
initial concentration: NaN
name: NDUFV2
has only substance units: false
boundary condition: true
is encoded by: hsa:4729
is: SBO:0000252
initial amount: NaN
constant: false
is: P19404

http://identifiers.org/biomodels.db/MODEL1310110016#_ec5937a7_4740_4e7c_8012_01490882012c
boundary condition: true
is: SBO:0000252
name: LDHC
type: Species
has only substance units: false
is encoded by: hsa:3948
initial amount: NaN
initial concentration: NaN
constant: false

metaM lnlccoa m
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
has only substance units: false
boundary condition: false
is: HMDB01064
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A

metaM lpchol hs e
is: CHEBI:60479
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
name: lysophosphatidylcholine
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaM 2obut m
name: 2-oxobutanoate
initial concentration: 1.0
is: CHEBI:16763
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: SBO:0000247
is: HMDB00005

metaR F1PGT
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
modifier: MODEL1310110016#
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_dcbf7581_3591_4f04_9a18_c01fb725616e
is: B7Z5T8
initial concentration: NaN
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR r1921
name: Y+LAT2 Utilized transport
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000185
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110016#

metaR URATEt
is described by: ECO:0000000
reversible: false
name: urate export from cytosol
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110016#
fast: false

metaM hs deg2 l
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 2
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB06254

metaR CRNCAR3tp
is: SBO:0000185
name: carnitine-propcarnitine carrier, peroxisomal
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
product: MODEL1310110016#

metaR r1567
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_09bb9928_8e27_4e4e_9f65_5d2a290d4d7a
is encoded by: hsa:8802
has only substance units: false
type: Species
initial concentration: NaN
has part: P53597
has part: Q96I99
is: SBO:0000297
initial amount: NaN
name: SUCLG2:SUCLG1
boundary condition: true
is encoded by: hsa:8801
constant: false

metaM HC01409 m
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:27540
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
name: Hexanoyl-CoA

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR ATPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reversible: true
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
name: ATP transporter, peroxisomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e9f870c8_c36c_4a13_af0c_d83fad141b6b
is: P11908
is encoded by: hsa:5634
has only substance units: false
constant: false
is: SBO:0000252
name: PRPS2
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_6746419b_06ef_4672_a9f4_3c49fb28dbff
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:175
is: P20933
has only substance units: false
initial amount: NaN
name: AGA
type: Species

metaR RTOTALt
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110016#
fast: false
is: SBO:0000185
reversible: true
name: RTOTAL transport

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM CE2417 m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB11123
initial concentration: 1.0
is: CHEBI:28387
type: Species
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110016#_5f5584c2_ef8b_499b_99c2_f2ec10fb6a7f
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: UAP1
initial concentration: NaN
is: Q16222
is encoded by: hsa:6675
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_0f5eb680_b5cf_4dd5_a534_5effb82611c0
has part: Q08ET0
has part: P56385
type: Species
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:10632
has part: P46459
has part: O75964
is: SBO:0000297
has part: A0PJH2
is encoded by: hsa:9551
is encoded by: hsa:4905
is encoded by: hsa:522
has only substance units: false
boundary condition: true
is encoded by: hsa:516
has part: P05496
initial concentration: NaN
has part: Q6IBB3
is encoded by: hsa:10476
constant: false
is encoded by: hsa:515
initial amount: NaN
is encoded by: hsa:521

metaR RE1903R
reactant: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
fast: false
kinetic law: MODEL1310110016#
reversible: true
name: RE1903
product: MODEL1310110016#
type: Reaction
is described by: ECO:0000000

metaR TSTSTERONEt
type: Reaction
name: Testosterone transport
fast: false
reversible: true
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:

metaM pmtcrn m
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
is: SBO:0000247
name: L-palmitoylcarnitine
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:17490
boundary condition: false

metaM HC02210 e
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110016#_538d05bb_50fa_4b0d_a86c_8f2f1d6e00f8
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q5VYT2
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4712
is: SBO:0000297
type: Species
is encoded by: hsa:4731

http://identifiers.org/biomodels.db/MODEL1310110016#_576b586e_53ef_4a9b_967c_3a6ee67539c8
is: P56134
boundary condition: true
is encoded by: hsa:9551
has only substance units: false
type: Species
constant: false
name: ATP5J2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_d7d7d0d8_9dc7_47a5_aaed_5b4b3774d3f4
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: P15531
has only substance units: false
is: SBO:0000252
constant: false
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110016#_4d75641a_fdc6_4a5d_b80e_3309c8f9ef84
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false
is encoded by: hsa:518
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_4ab67fed_4e87_4b12_b804_404c9f9f602e
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3423
initial amount: NaN
name: IDS
constant: false
is: P22304

metaR r2371
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: true

metaR AATAi
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
reversible: false
type: Reaction
modifier: MODEL1310110016#
name: 2-aminoadipate transaminase, irreversible

metaR r0553
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
reactant: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_4134e3c8_72bd_467f_beb9_d3db5b22393a
boundary condition: true
has only substance units: false
constant: false
type: Species
name: IDS
initial amount: NaN
initial concentration: NaN
is: B4DGD7
is: SBO:0000252
is encoded by: hsa:3423

metaR r1562
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
constant: false
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57337
is: SBO:0000247
is: HMDB02054

metaM xol7aone m
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17899
is: SBO:0000247
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_86ad539e_af59_4c03_94b5_96f2272fe688
has only substance units: false
type: Species
name: NT5M
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56953
constant: false
is: Q9NPB1

http://identifiers.org/biomodels.db/MODEL1310110016#_d16cd419_ac32_4f6e_9583_ca392b125ddc
name: GGT1
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P19440
type: Species
is encoded by: hsa:2678

http://identifiers.org/biomodels.db/MODEL1310110016#_386e005a_5f9c_402d_8076_4030d4ce12a7
initial concentration: NaN
initial amount: NaN
name: SLC4A8
is encoded by: hsa:9498
boundary condition: true
has only substance units: false
type: Species
constant: false
is: E7EML0
is: SBO:0000252

metaM ksii core2 deg3 l
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 3
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110016#_f4c47676_9075_4834_81ed_bce4b17d000c
is encoded by: hsa:51179
is: SBO:0000252
initial concentration: NaN
name: HAO2
is: Q9NYQ3
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_4e9be91b_ee3c_40ff_879f_d717544c3282
is: P47895
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ALDH1A3
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:220

metaR DCTPtn
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
name: dCTP diffusion in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_a559b2a0_0493_44c5_8ba0_95a5735c0724
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5831
initial amount: NaN
is: A6NFM2
type: Species
initial concentration: NaN
constant: false
name: PYCR1

http://identifiers.org/biomodels.db/MODEL1310110016#_d58ae191_9b93_4939_9aff_c65409afbdbd
constant: false
name: NDUFV3
is: P56181
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4731

metaM fucgalacglcgalgluside hs g
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01167
initial amount: NaN
is: CHEBI:17158
name: Type IH glycolipid
constant: false
initial concentration: 1.0
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0

metaR r1561
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
reactant: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM thmpp m
boundary condition: false
is: HMDB01372
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
name: Thiamine diphosphate
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:45931

metaM retinal c
name: retinal
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
type: Species
is: HMDB01358
is: CHEBI:15035
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9bd70762_73f6_4b8d_b424_9146a8aaa718
is encoded by: hsa:6240
name: RRM1
is: P23921
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2372
is described by: ECO:0000000
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

metaR ACHtn
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_c825772e_3041_4134_ab4a_7a60ed43e02d
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:2805
is: P17174
has only substance units: false
is: SBO:0000252
name: GOT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_e0587320_b8cf_4f02_80a4_4e34d1d5dba9
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFC1
is: SBO:0000252
is encoded by: hsa:4717
type: Species
boundary condition: true
is: O43677

http://identifiers.org/biomodels.db/MODEL1310110016#_37853d5c_bca1_4352_86b4_a7204746148a
name: GUSB
type: Species
initial amount: NaN
is: P08236
is encoded by: hsa:2990
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b624db2f_1139_4ef4_a7ad_aa56c65f8304
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: NDUFS2
is: B7Z792
is encoded by: hsa:4720
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2214a23c_d3b1_40d3_8dd9_6c69255e4b9b
constant: false
name: ALPI
is: P09923
has only substance units: false
is: SBO:0000252
is encoded by: hsa:248
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM HC02210 c
is: CHEBI:34939
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR AKR1C42
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
reversible: false
type: Reaction

metaR PI45P5P
fast: false
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110016#
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD

metaR NTD2e
modifier: MODEL1310110016#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (UMP), extracellular
reactant: MODEL1310110016#
type: Reaction
fast: false
kinetic law: MODEL1310110016#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR SULFOX
is: SBO:0000185
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
name: sulfite oxidase
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14729666 NOTES:MM/TDV; r0140
is described by: ECO:0000134
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110016#
product: MODEL1310110016#

metaM gchola c
is: HMDB00138
initial concentration: 1.0
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: CHEBI:58235
constant: false
boundary condition: false
name: glycocholate
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR ACOAD8m
kinetic law: MODEL1310110016#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110016#
reversible: false
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.10
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
reactant: MODEL1310110016#

metaR r2373
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110016#
reversible: true
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r1564
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR DCMPDA
name: dCMP deaminase
product: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.4.12
is described by: ECO:0000254
kinetic law: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
modifier: MODEL1310110016#
reversible: true
type: Reaction
fast: false

metaM dcacoa c
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
initial amount: NaN
constant: false
is: HMDB06404
has only substance units: false
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM HC01444 e
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15754
has only substance units: false
name: Galactosylglycerol
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial concentration: 1.0
boundary condition: false

metaM dcholcoa r
is: SBO:0000247
boundary condition: false
name: chenodeoxycholoyl coenzyme a
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
type: Species
is: CHEBI:28701
initial concentration: 1.0
has only substance units: false
is: HMDB06292

metaM Ser Gly Ala X Gly l
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00318
is: HMDB00062
is: SBO:0000247
is: CHEBI:16347
constant: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
has only substance units: false
notes: FORMULA: XH CHARGE: 0
type: Species

metaM ksi deg1 l
is: HMDB00174
has only substance units: false
initial concentration: 1.0
is: CHEBI:18287
initial amount: NaN
name: keratan sulfate I, degradation product 1
boundary condition: false
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
constant: false
type: Species

metaR KSII CORE4tly
reversible: false
fast: false
reactant: MODEL1310110016#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR D3AIBTm
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true

metaM acrn r
is: SBO:0000247
is: HMDB00201
initial amount: NaN
type: Species
is: CHEBI:57589
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110016#_74640f1c_ac1d_472a_b45b_1c90aa658514
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: Q9H6Y6
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4645
name: MYO5B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_237c27a0_2bd5_44ac_8033_52d62503fa93
has part: O95498
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: VNN3:VNN2:VNN1
boundary condition: true
constant: false
is encoded by: hsa:55350
is encoded by: hsa:8875
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110016#_345541b6_6c79_47cf_9fff_6bdb48663c6d
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: _U37519_1_e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:U37519

metaM retinol cis 11 c
name: 11-cis-retinol
is: SBO:0000247
is: CHEBI:16302
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06216
constant: false
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false

metaR AKR1C41
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110016#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#

metaR r0186
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
kinetic law: MODEL1310110016#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
reversible: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
is described by: ECO:0000000
fast: false

metaR EX cysam LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cysam
type: Reaction

metaR r0556
modifier: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
reversible: true
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000

metaR r2374
is described by: ECO:0000000
reactant: MODEL1310110016#
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR r1563
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaR ACACT1rm
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
modifier: MODEL1310110016#
product: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_62a78199_c3f9_4d37_b26f_3f638c983dae
boundary condition: true
name: NME6
is encoded by: hsa:10201
is: O75414
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_c1e26c42_c9be_4df8_aecb_cbf351df8e0d
is: SBO:0000252
is: Q6ZWP6
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27034
type: Species
name: ACAD8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_64386eff_2ae4_4856_b167_bc9c8e04dc8e
has only substance units: false
type: Species
initial concentration: NaN
name: COX6A2
is encoded by: hsa:1339
boundary condition: true
is: Q02221
is: SBO:0000252
constant: false
initial amount: NaN

metaM hs deg23 l
notes: FORMULA: C31H49NO29S CHARGE: -2
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
is: HMDB02704
has only substance units: false
boundary condition: false
is: CHEBI:21338

metaM acrn x
initial amount: NaN
name: O-acetylcarnitine
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00201
is: CHEBI:57589

http://identifiers.org/biomodels.db/MODEL1310110016#_6cb5f731_e1f1_44bf_bb91_1918c9e7e0a7
constant: false
name: HIBADH
is encoded by: hsa:11112
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: P31937
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_dee65a3b_5e08_4bef_9666_dfe2b3371efc
is encoded by: hsa:X63359
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: _X63359_1_c
is: SBO:0000252
initial amount: NaN

metaM cytd m
is: HMDB00089
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: cytidine

metaM i c
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
is: HMDB12238
constant: false
is: CHEBI:16382

metaR MCCCrm
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
fast: false
is: SBO:0000176
modifier: MODEL1310110016#
type: Reaction
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reversible: true
reactant: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.4.1.4

metaM aps c
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
name: 5'-adenylyl sulfate(2-)
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58243
is: HMDB01003
has only substance units: false

metaR r2375
is described by: ECO:0000000
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false

metaM 2obut c
is: C00109
is: SBO:0000247
has only substance units: false
name: 2-Oxobutanoate
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:16763
is: HMDB00005

metaM leuktrD4 r
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
name: Leukotriene D4

metaR 5MTHFt
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110016#

metaM ksi deg8 l
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 8
notes: FORMULA: C194H311N13O171S10 CHARGE: -10

metaR r1671
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
name: Y+LAT2 Utilized transport

metaR XOLDIOLONEt
reactant: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true

metaM HC02207 e
name: prostaglandin-c2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:27555
type: Species
has only substance units: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaR CDIPTr
name: phosphatidylinositol synthase (Homo sapiens)
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.8.11

metaR RE3272N
name: RE3272
product: MODEL1310110016#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR THYMt
modifier: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
fast: false
name: thymine reversible transport via facilated diffusion
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_b50d0f56_3186_4f61_b0b5_30c675ef28e8
has only substance units: false
boundary condition: true
is encoded by: hsa:4714
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: O95169
name: NDUFB8

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM HC02187 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28774
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247
constant: false
name: reverse-triiodthyronine

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction
reactant: MODEL1310110016#
reversible: false
product: MODEL1310110016#
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000

metaM ppa e
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:17272
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
name: propionate

metaR RE0915E
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
name: RE0915
fast: false
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaR r1670
fast: false
name: Y+LAT2 Utilized transport
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6afa6489_466a_4ed5_b484_55df32e5376c
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P80404
is encoded by: hsa:18
name: ABAT
constant: false

metaR NCNt
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
reversible: true
product: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
is described by: ECO:0000269
fast: false
name: Na+/Ca2+-NH4+ exchange

metaM HC01842 c
initial amount: NaN
name: Phosphodimethylethanolamine
is: CHEBI:31997
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
initial concentration: 1.0

metaR r2376
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaM glyald c
is: C00577
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01051
name: D-Glyceraldehyde
initial amount: NaN
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
has only substance units: false

metaR GALGLUSIDEtg
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: galgluside hs intracellular transport
product: MODEL1310110016#
is: SBO:0000185

metaR r0594
fast: false
kinetic law: MODEL1310110016#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110016#
modifier: MODEL1310110016#

metaR DGTPtn
type: Reaction
is: SBO:0000185
name: dGTP diffusion in nucleus
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
reversible: true

metaM Lkynr c
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: L-kynurenine
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00684

metaR UPPN
product: MODEL1310110016#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
kinetic law: MODEL1310110016#
is described by: ECO:0000269
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110016#
name: b-ureidopropionase

metaR PCHOLPm hs
is described by: ECO:0000269
name: choline phosphatase
modifier: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_ab53a83f_4ad6_4d22_b471_b6b85a0d24d3
is encoded by: hsa:9791
is: SBO:0000252
is: P48651
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: PTDSS1

metaM i e
type: Species
is: SBO:0000247
name: iodide
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
constant: false
is: HMDB12238
boundary condition: false
initial concentration: 1.0
is: CHEBI:16382

http://identifiers.org/biomodels.db/MODEL1310110016#_073ed452_487c_4b28_b0be_b06647198bad
initial concentration: NaN
is encoded by: hsa:56954
constant: false
type: Species
name: NIT2
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9NQR4
is: SBO:0000252

metaM acac c
name: acetoacetate
is: HMDB00060
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:13705
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM vitd3 c
is: SBO:0000247
is: CHEBI:28940
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
name: calciol
has only substance units: false
is: HMDB00876
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_9730312b_8ed0_402f_abfd_f279ef84a239
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: P11310
initial amount: NaN
is encoded by: hsa:34
initial concentration: NaN
name: ACADM

metaR PCRNtm
is: SBO:0000185
product: MODEL1310110016#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
type: Reaction
fast: false
name: transport into the mitochondria from cytosol (carnitine)
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM lnlccoa c
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064
constant: false
is: SBO:0000247
has only substance units: false
name: linoleic coenzyme A
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_c162acb6_8424_4033_b597_32c08e0dcc2d
type: Species
boundary condition: true
name: GCK
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2645
initial concentration: NaN
is: Q53Y25
initial amount: NaN

metaR 3DSPHR
modifier: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
product: MODEL1310110016#
name: 3-Dehydrosphinganine reductase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.102
reversible: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110016#_7cf516ea_3d2e_44b6_86fe_25d850385477
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: GBA
type: Species
is encoded by: hsa:2629
is: SBO:0000252

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110016#
modifier: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110016#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
kinetic law: MODEL1310110016#

metaR r0181
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110016#
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
reversible: true

metaM fpram c
is: CHEBI:58478
is: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06211
constant: false
has only substance units: false

metaR r2377
type: Reaction
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM h g
name: proton
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
initial amount: NaN
is: CHEBI:24636
type: Species

metaR ACGPID
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89
fast: false
modifier: MODEL1310110016#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reversible: false
type: Reaction

metaM fuc L c
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
constant: false
boundary condition: false
is: HMDB00174
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18287

metaM HC02207 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:27555
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
constant: false
name: prostaglandin-c2
boundary condition: false
initial concentration: 1.0

metaR N4Tg
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110016#
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus

metaR r0595
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
type: Reaction
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110016#
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
is: CHEBI:57795
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_524d1e69_a221_494f_84b7_709935288f50
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: _AA664770_1_m
initial concentration: NaN
is encoded by: hsa:AA664770
has only substance units: false

metaR RNMK
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
name: ribosylnicotinamide kinase
fast: false
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.7.1.22
product: MODEL1310110016#

metaM HC02187 e
name: reverse-triiodthyronine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28774
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR GPIMTer U
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
product: MODEL1310110016#
type: Reaction
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_8756a952_be74_4301_b260_1db9c554b3a5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: DGKE
is: A1L4Q0
has only substance units: false
is encoded by: hsa:8526
type: Species
constant: false

metaM 6a2ohxnt x
initial concentration: 1.0
constant: false
is: HMDB12151
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
name: 6-amino-2-oxohexanoic acid

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR NACHEX17ly
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a1a4e240_94cc_49e9_b72d_23de4e58091b
boundary condition: true
is: Q9HCQ5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50614
name: GALNT9
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_ad4a5159_116e_4702_816d_0c7767853ff4
is: P30613
boundary condition: true
is encoded by: hsa:5313
name: PKLR
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_0cdb39ae_3213_42fc_9808_4494dcb94fd8
type: Species
name: NDUFA11
boundary condition: true
is: C9JT23
constant: false
is encoded by: hsa:126328
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0552
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: HMDB00237
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17272
name: propionate
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

metaR r2378
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#

metaM ala L e
name: L-alanine
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
boundary condition: false
is: HMDB00161
is: CHEBI:16977
initial concentration: 1.0
initial amount: NaN
type: Species

metaR 3AIBtm
reactant: MODEL1310110016#
modifier: MODEL1310110016#
type: Reaction
name: 3-amino-isobutyrate transport, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110016#
is described by: ECO:0000000
product: MODEL1310110016#
reversible: false
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_db3c974b_80f2_4fd8_bca1_14c1e31ae6be
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8836
is: Q92820
boundary condition: true
initial amount: NaN
name: GGH
type: Species
constant: false
is: SBO:0000252

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_23fa2cba_7051_4534_91c2_3b65bedf6125
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFS5
has only substance units: false
is: Q6IBA0
constant: false
is encoded by: hsa:4725
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_b41636e3_8833_4529_bede_b5f96c79206b
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: O75251
type: Species
name: NDUFS7
has only substance units: false
boundary condition: true
is encoded by: hsa:374291

metaM CE5120 m
type: Species
name: trans-2-cis-8-tetradecadienoyl-CoA
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: CHEBI:12947

metaR r0596
fast: false
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
kinetic law: MODEL1310110016#
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_e6633028_886f_4af3_9546_04a2aa0834ba
constant: false
name: LPL
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4023
is: P06858
initial amount: NaN

metaM pmtcrn r
constant: false
name: L-palmitoylcarnitine
is: CHEBI:17490
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00222

metaM acac e
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:13705
has only substance units: false

metaM asp D c
is: CHEBI:29990
type: Species
constant: false
initial amount: NaN
name: D-aspartate(1-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: HMDB06483
boundary condition: false
initial concentration: 1.0

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
product: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
modifier: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#

metaR ACACT7p
is described by: ECO:0000269
fast: false
reversible: false
type: Reaction
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000176
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD

metaR r2379
reactant: MODEL1310110016#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110016#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110016#
reversible: true
is described by: ECO:0000000

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR r0647
is described by: ECO:0000000
is: SBO:0000176
name: Spontaneous reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
reversible: true
type: Reaction
product: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:

metaR SPHS1Pte
product: MODEL1310110016#
type: Reaction
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110016#
is: SBO:0000185

metaM ctp e
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
is: HMDB00082
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:37563
initial concentration: 1.0
initial amount: NaN

metaM h m
constant: false
initial amount: NaN
name: proton
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

metaM carn c
is: HMDB00033
is: SBO:0000247
name: carnosine
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:15727
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1

metaM rib D c
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00283
is: SBO:0000247
type: Species
has only substance units: false
name: D-ribose
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false

metaR RE3245C
reactant: MODEL1310110016#
name: RE3245
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is: SBO:0000176
fast: false
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction

metaM 3mop c
is: HMDB00491
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_8e8983bb_ae19_43bc_9db9_2be78fe314c6
is: SBO:0000252
name: ATP5C1
type: Species
is encoded by: hsa:509
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P36542

metaR ABTti
kinetic law: MODEL1310110016#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
name: L-arabinitol transport via passive diffusion
type: Reaction
reactant: MODEL1310110016#
fast: false
product: MODEL1310110016#

metaR NDPK8n
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reactant: MODEL1310110016#
is: SBO:0000176
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#

metaR r2308
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110016#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_b3470f6d_65fc_4917_9249_591b345236c0
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1892
has only substance units: false
is: P30084
name: ECHS1

metaR 3AIB Dtm
kinetic law: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
name: transport of 3aib_D into mitochondria
product: MODEL1310110016#
reversible: true
fast: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_a35ec9f1_835d_4111_a997_0c056fac6a52
name: NMNAT2
initial amount: NaN
constant: false
is encoded by: hsa:23057
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_82a14c66_d99d_4d3b_9ac0_c28159b86a3f
initial concentration: NaN
boundary condition: true
is: Q96CA6
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ACAA1
constant: false
is encoded by: hsa:30

metaM 34dhmald m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
has only substance units: false
is: HMDB06242
type: Species
name: 3,4-Dihydroxymandelaldehyde
is: C05577

http://identifiers.org/biomodels.db/MODEL1310110016#_aa2ea430_ed28_49e8_8c0d_3d5e2fb1aaf4
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q5JPA4
name: SLCO1C1
is encoded by: hsa:53919

metaM ala L c
is: SBO:0000247
type: Species
name: L-alanine
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
is: CHEBI:16977
is: HMDB00161
initial amount: NaN

metaR FAS120COA
name: fatty-acyl-CoA synthase (n-C12:0CoA)
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD

metaM h n
name: proton
initial amount: NaN
is: SBO:0000247
is: CHEBI:24636
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false

metaR r1569
kinetic law: MODEL1310110016#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
type: Reaction

metaM ksi deg41 l
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C34H58N2O26 CHARGE: 0
type: Species
constant: false
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 41
initial amount: NaN

metaM adp c
is: CHEBI:16761
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
is: C00008
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
fast: false
product: MODEL1310110016#
is: SBO:0000176
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1310110016#

metaM asp D e
constant: false
initial amount: NaN
is: CHEBI:29990
boundary condition: false
initial concentration: 1.0
name: D-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: HMDB06483
has only substance units: false
type: Species

metaR DNDPt22m
reversible: false
is: SBO:0000185
name: dTDP transport via dUDP antiport
modifier: MODEL1310110016#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110016#_08e9a105_57a0_4857_b7a2_e8a887d39376
has part: O95497
is: SBO:0000297
has only substance units: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875
has part: A8K7W0
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8876
initial concentration: NaN
is encoded by: hsa:55350

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM 4ppcys m
initial amount: NaN
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01117
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: CHEBI:59458
initial concentration: 1.0

metaM ctp c
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
boundary condition: false
is: C00063
name: CTP
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37563
constant: false
initial amount: NaN

metaM na1 c
is: CHEBI:4541
name: Sodium
is: C01330
constant: false
type: Species
boundary condition: false
is: HMDB00588
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM xol7ah2al m
initial concentration: 1.0
type: Species
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:27428
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894

metaM thm c
is: SBO:0000247
is: C00378
is: CHEBI:0
boundary condition: false
notes: FORMULA: C12H17N4OS CHARGE: 1
initial concentration: 1.0
initial amount: NaN
is: HMDB00235
type: Species
constant: false
has only substance units: false
name: Thiamin

http://identifiers.org/biomodels.db/MODEL1310110016#_edd77686_1ff5_4e12_b5fd_b63d49b433c1
name: _NM_013421_1_e
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:NM 013421

http://identifiers.org/biomodels.db/MODEL1310110016#_e35b665f_aa00_42bb_8278_087c90a86959
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: SLC22A5
initial concentration: NaN
type: Species
is: O76082
initial amount: NaN
is encoded by: hsa:6584

http://identifiers.org/biomodels.db/MODEL1310110016#_21476772_b461_4e90_9880_392a4df383a7
is: P28332
is encoded by: hsa:130
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: ADH6
has only substance units: false

metaM pail45p hs c
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_8fa51ecc_c474_494a_ab5e_5e667a92ecbc
initial amount: NaN
is: SBO:0000252
name: PPA2
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:27068

metaR CYOR u10m
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110016#
product: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
modifier: MODEL1310110016#
is: SBO:0000185
type: Reaction
name: ubiquinol-6 cytochrome c reductase, Complex III
is version of: http://identifiers.org/ec-code/3.5.1.92

metaM cala c
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB00026
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
initial amount: NaN
name: N-carbamoyl-beta-alaninate
constant: false
is: CHEBI:11892

http://identifiers.org/biomodels.db/MODEL1310110016#_989b3e16_fee3_4058_942d_0de5ee0bcd0d
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1718
is: Q15392
boundary condition: true
name: DHCR24
constant: false
is: SBO:0000252

metaR G5SADrm
is described by: ECO:0000000
product: MODEL1310110016#
fast: false
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_45ad5e69_8a6a_4167_8d49_d00bc1e09c50
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q8IZH9
has only substance units: false
initial amount: NaN
is encoded by: hsa:2643
name: GCH1

http://identifiers.org/biomodels.db/MODEL1310110016#_e0c8b1fc_5793_4011_bc1f_2e7dc8b27072
is encoded by: hsa:AV727634
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AV727634_1_c
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_1c48ab16_5deb_41b2_a9a7_4403729ea602
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:224
name: ALDH3A2
is: P51648
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM h l
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_066cefe5_5e75_4b7d_bd69_d50845405506
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR RE0830C
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
product: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
is: SBO:0000176
name: RE0830
is described by: ECO:0000000

metaR S6TASE2ly
reversible: true
modifier: MODEL1310110016#
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110016#

metaM ksi deg11 l
initial concentration: 1.0
is: HMDB00143
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate I, degradation product 11
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
boundary condition: false

metaR NACHEX12ly
modifier: MODEL1310110016#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110016#
product: MODEL1310110016#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#

metaM dgtp e
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01440
is: SBO:0000247
type: Species
is: CHEBI:16497
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ec2d19b9_0d7e_4a3d_9c69_81027a396156
boundary condition: true
has only substance units: false
is encoded by: hsa:10087
name: COL4A3BP
type: Species
initial amount: NaN
is: Q9Y5P4
initial concentration: NaN
constant: false
is: SBO:0000252

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR ESTRADIOLtr
is described by: ECO:0000000
reactant: MODEL1310110016#
type: Reaction
name: estradiol intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
product: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#

metaR r1925
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110016#
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_0190a5a3_76ce_40e2_a430_4537021f96f4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5742
name: PTGS1
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P23219
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_2325bbb9_01e5_4a53_bf25_fe00f55f293c
is: Q9NYW8
is encoded by: hsa:57786
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: RBAK
constant: false
type: Species
initial concentration: NaN

metaR r2309
product: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110016#_bfd39a2f_f66a_4ee9_bc8a_2429b3f18b79
is: P15289
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: ARSA
constant: false
is encoded by: hsa:410
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_975d9cfe_0883_4317_80ee_97a0173b6dce
name: SLC26A3
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: P40879
is: SBO:0000252
is encoded by: hsa:1811
has only substance units: false

metaR ICDHyrm
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
reversible: true
is described by: ECO:0000269

metaM spc hs c
is: SBO:0000247
has only substance units: false
name: sphingosylphosphorylcholine
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
constant: false
type: Species

metaM nicrnt c
type: Species
initial amount: NaN
name: Nicotinate D-ribonucleotide
has only substance units: false
is: SBO:0000247
is: HMDB01132
is: CHEBI:57502
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
boundary condition: false
is: C01185
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_369e1b6d_0699_402c_8846_608ebe4aee64
type: Species
is: SBO:0000252
is encoded by: hsa:79646
initial amount: NaN
name: PANK3
initial concentration: NaN
is: Q9H999
constant: false
boundary condition: true
has only substance units: false

metaR HSPGtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110016#
name: heparan sulfate transport, extracellular to lysosome
reactant: MODEL1310110016#
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110016#
is described by: ECO:0000000
type: Reaction

metaR ASPTA
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
name: aspartate transaminase
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is: SBO:0000176
reactant: MODEL1310110016#
is described by: ECO:0000269

metaR LEUKTRB4t
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110016#
name: leukotriene B4 transport
is described by: ECO:0000000
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_bf7748c2_d799_4c8c_870a_0ddeee0c2df0
initial amount: NaN
is: P53396
initial concentration: NaN
name: ACLY
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:47

metaR ENGASE3ly
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r1443
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
name: EC:1.3.3.6
reactant: MODEL1310110016#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR r1117
fast: false
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110016#
reversible: true
kinetic law: MODEL1310110016#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_72931bf5_471c_44fe_adf2_83f24c906a55
type: Species
initial concentration: NaN
is encoded by: hsa:570
boundary condition: true
has only substance units: false
name: BAAT
is: SBO:0000252
is: Q14032
constant: false
initial amount: NaN

metaR r0655
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is: SBO:0000176
fast: false
product: MODEL1310110016#
reversible: true

metaM arg L m
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
initial amount: NaN
name: L-argininium(1+)
is: CHEBI:32682
is: HMDB00517

metaM clpn hs c
type: Species
is: CHEBI:21338
initial amount: NaN
is: SBO:0000247
constant: false
name: clpn_hs[c]
is: HMDB02704
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CHARGE: 0

metaR GLYt7 311 r
type: Reaction
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is: SBO:0000185
is described by: ECO:0000006
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_43631c31_61d4_4ee2_b994_ea76ceec2462
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26873
name: OPLAH
constant: false
is: O14841
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_7be7d1c9_1bb2_4ab0_9c9d_14eafcec4e65
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: B4DK61
name: ACOX1
is encoded by: hsa:51
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_16cee2b4_afc4_4e69_953d_77c9b586578c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AA576959
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AA576959_1_c

http://identifiers.org/biomodels.db/MODEL1310110016#_69716415_0bdb_4591_97a4_b0fbc598b4d2
initial concentration: NaN
is: B2RD24
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:25902
type: Species
initial amount: NaN
name: MTHFD1L
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_04db7666_dfa1_49db_bc21_106afadb6a59
boundary condition: true
is: H0UI06
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: COX7A2
is: SBO:0000252
is encoded by: hsa:1347
type: Species

metaR DNDPt15m
name: dUDP transport via dGDP antiport
is described by: ECO:0000269
modifier: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR ASAH1
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.23
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
name: N-acylsphingosine amidohydrolase
modifier: MODEL1310110016#
product: MODEL1310110016#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#

metaM cit m
name: Citrate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16947
is: HMDB00094
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110016#_00b06e25_c5ed_41c6_89f4_96fa74109e24
boundary condition: true
has part: B4DY56
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:498
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaR PALFATPtc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6df7bdbd_c096_4c1e_8b75_d9b17e6d5950
initial concentration: NaN
boundary condition: true
name: ENPP1
is: SBO:0000252
is encoded by: hsa:5167
initial amount: NaN
is: P22413
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_b3a37d7d_f2c8_482d_a2ac_22984477348f
boundary condition: true
is encoded by: hsa:2686
initial amount: NaN
is: A0PJJ9
initial concentration: NaN
constant: false
is: SBO:0000252
name: GGT7
has only substance units: false
type: Species

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM na1 e
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
is: C01330
has only substance units: false
name: Sodium
is: SBO:0000247
is: CHEBI:4541
boundary condition: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR Rtotaltl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
product: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
fast: false
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_0b592c21_ca04_448f_b7da_e96f52bc505e
name: ACLY
constant: false
has only substance units: false
is encoded by: hsa:47
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM mthgxl c
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
name: methylglyoxal
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17158
initial concentration: 1.0

metaR GLCMter
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
kinetic law: MODEL1310110016#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
name: glucose transport via membrane vesicle
is: SBO:0000185
product: MODEL1310110016#

metaM spc hs e
initial amount: NaN
boundary condition: false
has only substance units: false
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR GGH 7THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
product: MODEL1310110016#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110016#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction

metaM acac m
is: CHEBI:13705
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_5006ab77_5d77_4489_990a_1130d42e7d32
initial amount: NaN
has only substance units: false
is: O75874
initial concentration: NaN
constant: false
is: SBO:0000252
name: IDH1
boundary condition: true
is encoded by: hsa:3417
type: Species

metaR r0656
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is: SBO:0000176
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_9aaee74b_f6dd_4f27_a9b9_e53e52f18f21
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:515
constant: false
name: ATP5F1
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM Ser Thr l
type: Species
has only substance units: false
constant: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
is: HMDB06254
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_9325e7c2_9d3a_480d_ac6d_02c91c5e398a
boundary condition: true
has only substance units: false
is encoded by: hsa:10559
name: SLC35A1
initial amount: NaN
constant: false
is: SBO:0000252
is: P78382
type: Species
initial concentration: NaN

metaR MECOALm
is described by: ECO:0000212
fast: false
modifier: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

metaM hdcea l
is: SBO:0000247
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
constant: false
name: palmitoleate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB03229

http://identifiers.org/biomodels.db/MODEL1310110016#_0c18b828_42b0_49b6_a1f9_2b000dbad0e2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:D29675
has only substance units: false
name: _D29675_1_c
boundary condition: true
type: Species
is: SBO:0000252

metaR C14STRr
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110016#
is described by: ECO:0000134
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
modifier: MODEL1310110016#
reversible: false
name: C-14 sterol reductase

http://identifiers.org/biomodels.db/MODEL1310110016#_33e95713_b170_48f6_863b_4f67f3a2fa49
has only substance units: false
is: SBO:0000252
name: PIGH
is encoded by: hsa:5283
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q14442

metaM doco13ac e
constant: false
type: Species
is: HMDB02068
initial concentration: 1.0
notes: FORMULA: C22H41O2 CHARGE: -1
has only substance units: false
is: SBO:0000247
name: docosenoic acid (C22:1)
boundary condition: false
initial amount: NaN

metaM CE2433 m
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial amount: NaN
constant: false
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433

http://identifiers.org/biomodels.db/MODEL1310110016#_e35dfd44_7203_4d57_929d_83a241aa31a9
constant: false
initial concentration: NaN
type: Species
is: P07451
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:761
boundary condition: true
name: CA3

metaR OPAHir
reactant: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
is described by: ECO:0000134
name: 5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.9
product: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (26873.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.5.2.9 Confidence Level: 4 AUTHORS: PMID:9751079 NOTES:AF Added from KEGG
modifier: MODEL1310110016#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_fe0a9e34_f48e_4204_8b34_087e26350d45
is encoded by: hsa:33
is: P28330
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: ACADL
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110016#_6b9e2b2d_2f7c_4233_a44c_81b095b270e7
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:151531
type: Species
is: O95045
boundary condition: true
name: UPP2
initial amount: NaN

metaM ppa m
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: CHEBI:17272
name: propionate
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00237
constant: false

metaR DURAD
is described by: ECO:0000269
modifier: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110016#
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01176
has only substance units: false

metaM ksii core4 deg3 l
boundary condition: false
is: SBO:0000247
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 3
is: HMDB00143
type: Species
constant: false
is: CHEBI:12936

metaR IDPtn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
fast: false
is: SBO:0000185
name: IDP nuclear transport

metaM lnlccrn m
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06469
name: Linoleyl carnitine
boundary condition: false

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_0b698944_cfce_4a12_941e_8c5b1706c75e
type: Species
name: _R39999_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:R39999
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaR r0926
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
kinetic law: MODEL1310110016#
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
product: MODEL1310110016#
reversible: false
reactant: MODEL1310110016#
fast: false

metaR EX glgchlo LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-glycocholate complex
type: Reaction

metaR GALGLUSIDEtl
is: SBO:0000185
product: MODEL1310110016#
type: Reaction
name: galgluside hs intracellular transport
reversible: true
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_811111e6_2cf0_4525_8d27_f008bb9e6f71
type: Species
is: SBO:0000252
constant: false
is: Q96CD2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:60490
has only substance units: false
initial amount: NaN
name: PPCDC

http://identifiers.org/biomodels.db/MODEL1310110016#_51a687a2_a772_4037_8cb9_51682ee2b689
name: DGKB
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:1607
is: Q9Y6T7
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR CLHCO3tex2
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110016#
name: chloride transport via bicarbonate countertransport (2:1)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
modifier: MODEL1310110016#
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaR r0590
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110016#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
product: MODEL1310110016#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
type: Species
is: SBO:0000247
name: proton
is: C00080
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_ccdce0e1_8202_4313_b850_88bdabda319e
initial concentration: NaN
has only substance units: false
is encoded by: hsa:R51273
name: _R51273_1_c
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaM xu5p D c
has only substance units: false
is: HMDB00868
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: D-xylulose 5-phosphate(2-)
boundary condition: false
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209

metaR r0650
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110016#
is: SBO:0000176
fast: false
product: MODEL1310110016#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_3d7eb976_fc6e_4d9b_876a_d400b8a1ff24
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: O00154
has only substance units: false
name: ACOT7
is encoded by: hsa:11332

http://identifiers.org/biomodels.db/MODEL1310110016#_c26ef54d_7d94_4560_a695_8db3cfa7d3a4
constant: false
is encoded by: hsa:4832
initial concentration: NaN
type: Species
initial amount: NaN
name: NME3
is: Q13232
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r0714
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
fast: false
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000
is: SBO:0000176

metaR P4503A7r
reactant: MODEL1310110016#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.14.14.1
notes: GENE_ASSOCIATION: (1551.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2722762 NOTES:_3 beta hydroxylation of testosterone NJ
is described by: ECO:0000269
reversible: false
name: cytochrome p450 P450 3A7
modifier: MODEL1310110016#
product: MODEL1310110016#
fast: false

metaM ctp n
name: CTP(4-)
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00082
is: CHEBI:37563
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_8284f907_6072_4357_b79c_29af520c35e9
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4711
initial amount: NaN
has only substance units: false
name: NDUFB5
boundary condition: true
is: O43674
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_4842d1bb_6d23_4b58_bf0c_9586724f7b51
name: EPX
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8288
initial concentration: NaN
is: P11678
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM CE0849 m
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:57795
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

metaM dnad c
is: C00857
constant: false
is: HMDB01179
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18304
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial concentration: 1.0
name: Deamino-NAD+
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_e6093668_a3e9_47af_bce2_f13a77039672
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACOT7
is: SBO:0000252
is encoded by: hsa:11332
type: Species
constant: false
is: O00154

http://identifiers.org/biomodels.db/MODEL1310110016#_73b02c4a_5456_431d_8f93_f7555611cbae
boundary condition: true
name: OCRL
constant: false
is encoded by: hsa:4952
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_5a6cf112_060e_4cf8_9d59_472a14372a50
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: Q5JT09
initial concentration: NaN
name: UCK1
is encoded by: hsa:83549
constant: false
has only substance units: false

metaR PNTOte
name: Transport of (R)-Pantothenate
fast: false
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110016#
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110016#
is: SBO:0000185

metaM ala L m
initial concentration: 1.0
type: Species
constant: false
is: HMDB00161
boundary condition: false
is: CHEBI:16977
name: L-alanine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
initial amount: NaN

metaR SO4CLtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110016#
reversible: false
modifier: MODEL1310110016#
is: SBO:0000185
fast: false

metaR DTDPtn
kinetic law: MODEL1310110016#
is: SBO:0000185
fast: false
reactant: MODEL1310110016#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110016#
is described by: ECO:0000000
name: dTDP nuclear transport

metaR r0651
product: MODEL1310110016#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110016#
reversible: true
fast: false
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR RE1523M
reactant: MODEL1310110016#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reversible: true
name: RE1523
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
modifier: MODEL1310110016#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110016#_90cf281d_a1a3_4c6d_9d44_5249e48c5994
initial amount: NaN
is: SBO:0000297
type: Species
has part: P82251
has only substance units: false
is encoded by: hsa:6519
constant: false
has part: Q07837
boundary condition: true
is encoded by: hsa:11136
name: SLC7A9:SLC3A1
initial concentration: NaN

metaM Sfglutth c
is: HMDB01550
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57688
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
constant: false
has only substance units: false
name: S-formylglutathionate(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110016#_4cac056e_5b1a_4ca2_a24f_fedf540742f9
has only substance units: false
initial concentration: NaN
is: P35475
type: Species
name: IDUA
boundary condition: true
initial amount: NaN
is encoded by: hsa:3425
is: SBO:0000252
constant: false

metaR r0924
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.204.5
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15209530 NOTES:
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a39fffc7_8b77_4bc9_a9a2_8d1b02a6f054
initial concentration: NaN
is encoded by: hsa:M68895
initial amount: NaN
boundary condition: true
constant: false
name: _M68895_1_c
type: Species
is: SBO:0000252
has only substance units: false

metaR r1446
product: MODEL1310110016#
type: Reaction
reversible: false
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM srtn c
constant: false
is: HMDB00259
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
has only substance units: false
name: serotonin(1+)
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_70717ca4_5667_49e4_8bfe_948b198f232e
constant: false
initial amount: NaN
is: SBO:0000252
is: P49327
has only substance units: false
boundary condition: true
is encoded by: hsa:2194
type: Species
name: FASN
initial concentration: NaN

metaM acrn c
is: CHEBI:57589
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
has only substance units: false
is: HMDB00201

metaM tststerone c
boundary condition: false
is: CHEBI:17347
name: testosterone
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_303c4166_3387_46f7_8837_aba6a90a1336
initial concentration: NaN
is: C9JC79
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SCP2
type: Species
is encoded by: hsa:6342
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110016#_9cc6cec1_fbd7_4780_b3dc_fc698e064bbb
is: SBO:0000252
is: O15269
boundary condition: true
type: Species
name: SPTLC1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10558
has only substance units: false
constant: false

metaM HC02217 e
is: CHEBI:27647
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: prostaglandin-g2
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaM ctp m
has only substance units: false
initial concentration: 1.0
name: CTP(4-)
constant: false
is: CHEBI:37563
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species

metaM methf m
type: Species
is: HMDB01354
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
is: CHEBI:57455
constant: false
has only substance units: false
initial concentration: 1.0

metaM gln L m
is: HMDB00641
constant: false
is: CHEBI:18050
has only substance units: false
name: L-glutamine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN

metaR SPODMx
is: SBO:0000176
modifier: MODEL1310110016#
is described by: ECO:0000269
product: MODEL1310110016#
kinetic law: MODEL1310110016#
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
name: superoxide dismutase, peroxisome
reactant: MODEL1310110016#
fast: false

metaM thmmp c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: CHEBI:37575
type: Species
constant: false
is: HMDB02666
name: Thiamin monophosphate
is: SBO:0000247
boundary condition: false
is: C01081

metaM vitd3 e
boundary condition: false
is: CHEBI:28940
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN
is: HMDB00876
initial concentration: 1.0
constant: false
is: SBO:0000247
name: calciol
has only substance units: false

metaM 4abut n
is: C00334
initial concentration: 1.0
boundary condition: false
name: 4-Aminobutanoate
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00112
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_d4c04475_3325_4b7b_92b3_17454728c210
boundary condition: true
is: O95497
constant: false
has only substance units: false
name: VNN1
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8876

metaR r0652
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
modifier: MODEL1310110016#
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_c4bb54b8_0245_4d76_b333_9a73b352a3d9
is: Q8TB61
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:347734
constant: false
name: SLC35B2

metaR PItn
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
name: phosphate transport, nuclear
reactant: MODEL1310110016#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR ILETA
name: isoleucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110016#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110016#
reversible: true
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110016#

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: C04352
type: Species
initial amount: NaN
is: CHEBI:59458
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01117
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false

metaM dcamp c
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
is: C03794
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57567
initial amount: NaN
is: HMDB00536
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794

metaM h c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110016#_f45febf1_3c8c_4cfd_b114_5ed35dba931a
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110016#_37eacd86_4255_413e_8f5d_5a0ed28a6fa8
is encoded by: hsa:AA788780
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AA788780_1_c
boundary condition: true
type: Species
initial amount: NaN

metaM dgtp m
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
is: CHEBI:16497
initial amount: NaN
is: SBO:0000247
is: C00286
boundary condition: false
is: HMDB01440
has only substance units: false
name: dGTP
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110016#_f3588e94_4d9d_4533_b7b2_29e4db60057d
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:518
initial concentration: NaN
is: SBO:0000252
constant: false
name: ATP5G3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_0dd7d9fa_3a7b_41a5_96a0_e093977d8ff3
name: HK1
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P19367
initial concentration: NaN
is encoded by: hsa:3098
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110016#_73111f56_516e_4e9b_b39a_fe770285c3f8
is encoded by: hsa:1040
is: SBO:0000252
initial concentration: NaN
name: CDS1
boundary condition: true
is: Q92903
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_0049d4c7_e24d_49b5_97ab_82640b3c0999
is encoded by: hsa:AI769281
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: _AI769281_1_e
has only substance units: false
boundary condition: true
initial amount: NaN

metaM cmpacna c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB01176
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM 4abut m
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00334
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
boundary condition: false
is: CHEBI:16865
name: 4-Aminobutanoate
is: HMDB00112
constant: false

metaM CE4876 r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12947
name: delta12-Prostaglandin J2
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaR ARGtm
fast: false
name: arginine mitochondrial transport via ornithine carrier
reversible: true
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
modifier: MODEL1310110016#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_3a594140_5f7a_4666_b296_cec0bfd0a1f6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:158
has only substance units: false
type: Species
name: ADSL
constant: false
initial amount: NaN
is: SBO:0000252

metaR r0591
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
product: MODEL1310110016#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110016#_bdaf7050_239d_40e2_856a_2591082798c3
name: SLC35D2
type: Species
is: SBO:0000252
constant: false
is: Q76EJ3
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:11046

metaR r0653
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
product: MODEL1310110016#
fast: false
reversible: false
kinetic law: MODEL1310110016#

metaM 1p3h5c m
constant: false
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
is: HMDB01369
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
initial amount: NaN

metaR ACCOAtr
name: acetyl-coa transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110016#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
reversible: true
product: MODEL1310110016#

metaM tststerone e
is: CHEBI:17347
boundary condition: false
name: testosterone
constant: false
is: HMDB00234
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species

metaM glyc R c
initial amount: NaN
type: Species
name: D-glycerate
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00139
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaM dgtp n
name: dGTP
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: CHEBI:16497
constant: false
boundary condition: false
is: HMDB01440
type: Species

metaM CE4794 m
initial concentration: 1.0
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
constant: false
name: cis-6-dodecenoyl-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:12947

metaM mthgxl e
initial concentration: 1.0
has only substance units: false
name: methylglyoxal
constant: false
is: CHEBI:17158
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r1116
is: SBO:0000185
product: MODEL1310110016#
fast: false
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
kinetic law: MODEL1310110016#
reversible: true
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110016#_8c16fa39_35ce_453d_94c5_d67731a31640
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:54995
boundary condition: true
name: OXSM
initial concentration: NaN
constant: false
is: Q9NWU1
is: SBO:0000252

metaM srtn e
is: HMDB00259
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: serotonin(1+)
boundary condition: false
is: CHEBI:350546
initial concentration: 1.0

metaR ASPt6
reactant: MODEL1310110016#
modifier: MODEL1310110016#
reversible: false
kinetic law: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
name: L-aspartate transport via Na, H symport and K antiport
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
product: MODEL1310110016#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110016#_e6464602_bb7d_4dc1_bd55_94e24157be4e
is encoded by: hsa:5320
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: PLA2G2A
initial amount: NaN
has only substance units: false
is: P14555
type: Species

http://identifiers.org/biomodels.db/MODEL1310110016#_4ef1737d_9a8a_4b99_af78_be0b5b6928d3
name: GNMT
is: Q14749
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:27232
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM HC02217 c
is: CHEBI:27647
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: prostaglandin-g2
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
is: SBO:0000247

metaM dcholcoa x
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06292
boundary condition: false
is: CHEBI:28701

metaM ksi deg36 l
is: SBO:0000247
constant: false
is: HMDB00143
name: keratan sulfate I, degradation product 36
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C62H103N4O49S1 CHARGE: -1

metaR NADS2
product: MODEL1310110016#
reactant: MODEL1310110016#
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
modifier: MODEL1310110016#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110016#

metaM hdcea r
name: palmitoleate
is: CHEBI:32372
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB03229
type: Species
has only substance units: false
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110016#_e6f1298c_2289_4efb_b6bd_6a1091fb1511
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:53354
is: Q8TE04
name: PANK1
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaR CYTK14
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110016#
kinetic law: MODEL1310110016#
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0718
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110016#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110016#

metaM arg L c
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
type: Species
is: HMDB00517
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32682

http://identifiers.org/biomodels.db/MODEL1310110016#_67d2e970_eae2_45e7_806b_faefd9342226
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: E9KL44
is encoded by: hsa:3030
name: HADHA
boundary condition: true
initial amount: NaN

metaR ORNt3m
reversible: true
is: SBO:0000185
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110016#
modifier: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000269
type: Reaction
fast: false
name: ornithine mitochondrial transport via proton antiport

metaM 10fthf5glu e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
type: Species
is: CHEBI:57454
constant: false
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](5)
has only substance units: false

metaR CSNAT3x
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110016#
is: SBO:0000176
fast: false
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000269
kinetic law: MODEL1310110016#
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
name: carnitine O-aceyltransferase, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110016#_7d7a4fb4_557e_447f_8ee4_1b8369b67a2b
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: INPP5B
initial amount: NaN
is: P32019
has only substance units: false
is encoded by: hsa:3633
constant: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_bc52a925_c54f_4574_baf9_08ba291685c1
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P14550
name: AKR1A1
type: Species
has only substance units: false
is encoded by: hsa:10327
boundary condition: true

metaR r0717
type: Reaction
reactant: MODEL1310110016#
kinetic law: MODEL1310110016#
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110016#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR RE0944E
modifier: MODEL1310110016#
fast: false
is: SBO:0000176
type: Reaction
name: RE0944
is described by: ECO:0000000
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM cit e
boundary condition: false
is: CHEBI:16947
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
name: citrate(3-)
constant: false
type: Species

metaR DM gpi sig er
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_3ca76f16_41ee_49d5_9146_4a1ef7661e22
type: Species
is encoded by: hsa:51292
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q86T14
name: GMPR2

metaR AICARte
reactant: MODEL1310110016#
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
product: MODEL1310110016#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110016#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR AMY2e
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110016#
is described by: ECO:0000000
reactant: MODEL1310110016#
is: SBO:0000176
name: alpha-amylase, extracellular (glygn2 -> glygn4)
kinetic law: MODEL1310110016#
fast: false

metaR 2HBO
is: SBO:0000176
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
reversible: true
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110016#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110016#_047c62af_22c1_43a8_881b_ce61a5ae8e64
type: Species
is: SBO:0000252
is: P31040
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6389
name: SDHA
boundary condition: true

metaR S6TASE15ly
modifier: MODEL1310110016#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110016#
is described by: ECO:0000000
kinetic law: MODEL1310110016#
reversible: true
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR ETFQO
is version of: http://identifiers.org/ec-code/1.5.5.1
reversible: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is: SBO:0000176
fast: false
modifier: MODEL1310110016#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06469
initial amount: NaN
type: Species
name: Linoleyl carnitine

metaR INSTt2r
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
name: inositol transport in via proton symport
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110016#
modifier: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_dbe4da2a_3d7b_4f82_b447_1f3291a76bb4
is encoded by: hsa:4698
has only substance units: false
is: Q16718
initial concentration: NaN
constant: false
is: SBO:0000252
name: NDUFA5
initial amount: NaN
boundary condition: true
type: Species

metaM CE2432 m
is: CHEBI:57795
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
has only substance units: false
constant: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110016#
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_6486e7c2_fd67_409b_8909_29a7adf09ce6
constant: false
is: SBO:0000252
is encoded by: hsa:AA614647
initial concentration: NaN
name: _AA614647_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaM man c
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00169
is: C00159
is: CHEBI:16024
name: D-Mannose
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaM arg L e
type: Species
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
has only substance units: false
name: L-argininium(1+)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32682
constant: false

metaR r0716
product: MODEL1310110016#
is: SBO:0000176
kinetic law: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaM ru5p D c
is: CHEBI:58121
initial concentration: 1.0
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00618
constant: false

metaR FUCtly
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
kinetic law: MODEL1310110016#
product: MODEL1310110016#
fast: false
reversible: false
name: L-fucose efflux from lysosome
is: SBO:0000185

metaR DITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110016#
is: SBO:0000185
name: dITP nuclear transport
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110016#
type: Reaction
product: MODEL1310110016#

metaM pyr e
is: SBO:0000247
initial concentration: 1.0
name: pyruvate
constant: false
type: Species
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
is: HMDB00243
initial amount: NaN
has only substance units: false

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
is: HMDB01493
constant: false
initial amount: NaN
is: CHEBI:57344
is: SBO:0000247
initial concentration: 1.0
name: 3-methylbut-2-enoyl-CoA(4-)
boundary condition: false
has only substance units: false

metaR r1560
is: SBO:0000185
reactant: MODEL1310110016#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110016#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110016#
type: Reaction
fast: false

metaR ALAGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: L-alanine/glycine reversible exchange
fast: false
kinetic law: MODEL1310110016#
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
modifier: MODEL1310110016#
is described by: ECO:0000304

metaR r0715
reversible: false
product: MODEL1310110016#
type: Reaction
reactant: MODEL1310110016#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110016#
is version of: http://identifiers.org/ec-code/6.3.2.5
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110016#

http://identifiers.org/biomodels.db/MODEL1310110016#_a8fce69d_3cd0_4bb0_b3c3_5300ee247701
is: SBO:0000252
name: ALDH1A2
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:8854
initial concentration: NaN
initial amount: NaN
is: F5H2Y9

metaR ACCOAtn
is described by: ECO:0000000
reactant: MODEL1310110016#
reversible: true
is: SBO:0000185
product: MODEL1310110016#
type: Reaction
kinetic law: MODEL1310110016#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear
fast: false

metaR MAN1PT2
modifier: MODEL1310110016#
reactant: MODEL1310110016#
product: MODEL1310110016#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
name: mannose-1-phosphate guanylyltransferase (GDP)
is: SBO:0000176
kinetic law: MODEL1310110016#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.13
reversible: false
is described by: ECO:0000000
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110016#
product: MODEL1310110016#
reactant: MODEL1310110016#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110016#_1e2c4e95_5cff_4c63_bfed_2d92b3ab2afa
is: P30837
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:219
name: ALDH1B1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110016#_0c603d7e_0505_425e_858c_9811d37521a4
initial concentration: NaN
constant: false
type: Species
is: Q9Y6L6
has only substance units: false
boundary condition: true
is encoded by: hsa:10599
initial amount: NaN
is: SBO:0000252
name: SLCO1B1

metaR BUTt2r
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110016#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
modifier: MODEL1310110016#
name: Butyrate transport via proton symport, reversible
product: MODEL1310110016#
kinetic law: MODEL1310110016#

metaM pmtcrn c
is: HMDB00222
name: L-palmitoylcarnitine
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
constant: false
initial concentration: 1.0
is: SBO:0000247