metaM pail3p hs c
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
type: Species
is: CHEBI:58088

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110015#
is: SBO:0000185
fast: false
type: Reaction
name: O2 transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR ASNtm
is: SBO:0000185
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
type: Reaction
is described by: ECO:0000000
name: L-asparagine transport, mitochondrial
fast: false

metaR r0202
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction
kinetic law: MODEL1310110015#
reversible: true

metaM HC01407 m
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
boundary condition: false
is: SBO:0000247
type: Species
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
is: CHEBI:28276
constant: false
has only substance units: false

metaM oxa c
is: CHEBI:30623
is: HMDB02329
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM core3 g
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16250
type: Species
boundary condition: false
has only substance units: false
name: Core 3

metaR r0647
is: SBO:0000176
name: Spontaneous reaction
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaM hs deg2 l
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06210
initial concentration: 1.0
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
boundary condition: false
type: Species
name: heparan sulfate, degradation product 2
is: SBO:0000247

metaM for e
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
is: HMDB00142
name: formate
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15740
has only substance units: false
initial concentration: 1.0

metaM lnlccrn c
initial concentration: 1.0
type: Species
boundary condition: false
name: Linoleyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
is: HMDB06469
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0942
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaM cl e
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
name: Chloride
initial amount: NaN
is: CHEBI:3966
is: HMDB00492
is: C00115
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR PEAMNO
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
name: Phenethylamine oxidase
modifier: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613

metaR OXAHCOtex
name: oxalate transport via bicarbonate countertransport
is described by: ECO:0000304
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM ins e
initial concentration: 1.0
is: CHEBI:17596
boundary condition: false
name: Inosine
initial amount: NaN
is: HMDB00195
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
constant: false

metaR r0941
reactant: MODEL1310110015#
reversible: true
name: Free diffusion
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
kinetic law: MODEL1310110015#

metaR r0196
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR r2320
reversible: true
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
fast: false
is described by: ECO:0000000

metaR RE3346C
reactant: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: true
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaR r1446
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
name: EC:1.3.3.6
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_bffedd97_b6f8_4ea8_a2dc_42c4132fc001
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: B4GALT1
is: P15291
initial amount: NaN
is encoded by: hsa:2683
constant: false
is: SBO:0000252

metaM orn m
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:46912
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00214
has only substance units: false
is: C01602
name: Ornithine
initial concentration: 1.0

metaR r1559
reactant: MODEL1310110015#
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR NACHEX11ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
name: beta-N-acetylhexosaminidase, lysosomal

metaR FUCASE2e
is version of: http://identifiers.org/ec-code/3.2.1.51
fast: false
modifier: MODEL1310110015#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: alpha-fucosidase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110015#_37d86940_9c69_4a57_a098_b0910ab616f6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q02127
name: DHODH
boundary condition: true
has only substance units: false
is encoded by: hsa:1723
type: Species

metaM gpail hs c
initial concentration: 1.0
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17049
boundary condition: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
type: Species

metaR RE1903R
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
name: RE1903
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
fast: false
product: MODEL1310110015#
reversible: true

metaR H3ETer
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
kinetic law: MODEL1310110015#
fast: false
reversible: false
is described by: ECO:0000304
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110015#_c0bfb029_e229_4128_a5eb_f9bbf039bd32
name: PRDX2
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:7001
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_ba6e0ce6_319e_46c7_8f33_05d9bdcf15fb
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r0940
is: SBO:0000185
product: MODEL1310110015#
reversible: true
name: Free diffusion
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_6fb9fa84_0b68_4176_a891_1fe4b484b163
constant: false
initial concentration: NaN
initial amount: NaN
name: HAS1
type: Species
is: SBO:0000252
is encoded by: hsa:3036
boundary condition: true
has only substance units: false
is: Q8IYH3

metaR PRPNCOAHYDm
name: Propenoyl-CoA hydrolase (m)
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#

metaR GMPtg
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
name: GMP transport (Golgi)
reversible: true

metaM cs a deg5 l
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
is: CHEBI:15936
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5

http://identifiers.org/biomodels.db/MODEL1310110015#_ec265018_1342_42a0_9e41_42e88da74846
is encoded by: hsa:4329
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: Q02252
constant: false
initial concentration: NaN
name: ALDH6A1

http://identifiers.org/biomodels.db/MODEL1310110015#_247a35a7_ad79_4592_8e4f_84797d9e29b8
is encoded by: hsa:6476
is: P14410
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SI
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1d7b1a30_2e46_4b3b_abe0_f78246e5e3b0
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2591
constant: false
boundary condition: true
name: GALNT3
is: Q14435

http://identifiers.org/biomodels.db/MODEL1310110015#_ad4ad9f0_dbd5_4303_af66_9db7af39bed2
is: D3DX95
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: CHAT

metaR r1449
is described by: ECO:0000000
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#
type: Reaction

metaM oxa e
is: HMDB02329
has only substance units: false
is: SBO:0000247
name: oxalate(2-)
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:30623
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR S6T3g
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR ENGASEly
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction

metaR CHOLESTle
product: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.1.13
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: hydrolysis of cholesterol ester by cholesterol esterase
is: SBO:0000176
reactant: MODEL1310110015#

metaM ins c
constant: false
boundary condition: false
is: CHEBI:17596
name: Inosine
has only substance units: false
is: HMDB00195
initial amount: NaN
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
is: C00294
initial concentration: 1.0
is: SBO:0000247

metaM mescon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00749
has only substance units: false
name: Mesaconate
is: CHEBI:36986

metaM hs deg10 l
name: heparan sulfate, degradation product 10
boundary condition: false
is: CHEBI:15748
initial amount: NaN
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110015#_0a466ff5_85ca_4301_8adf_ca42a0ccb834
type: Species
initial amount: NaN
boundary condition: true
is: P07954
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2271
name: FH
is: SBO:0000252

metaM hgentis c
has only substance units: false
is: CHEBI:16169
boundary condition: false
constant: false
initial amount: NaN
name: homogentisate
is: SBO:0000247
is: HMDB00130
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species

metaR r0644
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
reactant: MODEL1310110015#
reversible: true
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

metaM ac e
is: CHEBI:30089
name: acetate
initial concentration: 1.0
is: HMDB00042
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false

metaR GPIAT
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction
fast: false
name: glucosaminylphosphatidyl inositol acetyltransferase
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is described by: ECO:0000269
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
product: MODEL1310110015#

metaM HC00250 e
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
type: Species
initial concentration: 1.0

metaR r0717
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110015#

metaM sql r
has only substance units: false
initial amount: NaN
is: CHEBI:15440
type: Species
boundary condition: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
initial concentration: 1.0
is: HMDB00256
constant: false
name: squalene

metaR r2323
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR TDCHOLAtx
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110015#

metaR r0191
reversible: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.24
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_e6c9e9dc_1473_4254_ba0b_3c6a182a1d6c
is: Q92835
constant: false
is: SBO:0000252
name: INPP5D
has only substance units: false
boundary condition: true
is encoded by: hsa:3635
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0946
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110015#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR FAOXC142C122m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_d16d98f4_80dd_46b7_9169_ade0a01f2d8b
is: SBO:0000252
boundary condition: true
name: NT5M
is: Q9NPB1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:56953
has only substance units: false

metaR FAOXC181C161m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR r0642
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110015#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_caece717_d97f_488a_96ab_e32c3d0c141d
constant: false
is: SBO:0000252
is: Q9NY65
initial amount: NaN
initial concentration: NaN
name: EHHADH
boundary condition: true
type: Species
is encoded by: hsa:1962
has only substance units: false

metaM fum c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial concentration: 1.0
constant: false
is: HMDB00134
type: Species
is: CHEBI:29806
name: Fumarate
initial amount: NaN
boundary condition: false
is: C00122

metaR r2324
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction

metaM gdpfuc g
initial concentration: 1.0
boundary condition: false
name: GDP-L-fucose(2-)
is: HMDB01095
initial amount: NaN
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaR ATPH1e
name: ATP diphosphohydrolase
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
kinetic law: MODEL1310110015#
type: Reaction
reversible: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110015#_920151a9_8375_44fa_a4d5_0086af765276
is: P52824
has only substance units: false
initial amount: NaN
name: DGKQ
type: Species
is encoded by: hsa:1609
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR GLACter
is: SBO:0000185
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
reversible: true

metaM HC00250 c
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
name: hydrosulfide
initial concentration: 1.0
is: CHEBI:29919
boundary condition: false

metaM dcmp n
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
boundary condition: false
is: CHEBI:57566
is: HMDB01202
name: dCMP(2-)

metaR RE2814R
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110015#
name: RE2814
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaR GASNASEly
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: glycosylasparaginase, lysosomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110015#
reversible: false

metaR r2321
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction

metaR r0641
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110015#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_f262f189_ab0d_4039_b65f_7f0594ccacb2
is encoded by: hsa:6391
type: Species
is: Q99643
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SDHC
constant: false

metaR r0193
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

http://identifiers.org/biomodels.db/MODEL1310110015#_40f87275_0cec_4778_8bfe_792cca7ded56
name: TPO
initial amount: NaN
is: P07202
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:7173
constant: false
has only substance units: false

metaR CYSGLYexR
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
reversible: true
name: L-cysteine/glycine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

http://identifiers.org/biomodels.db/MODEL1310110015#_d8e779e6_5bd4_448d_82be_72b2da999bdd
boundary condition: true
is encoded by: hsa:AV717590
constant: false
name: _AV717590_1_c
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaM cl c
constant: false
type: Species
name: Chloride
initial concentration: 1.0
is: C00115
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
is: CHEBI:3966
is: SBO:0000247
is: HMDB00492
has only substance units: false
boundary condition: false

metaR r0944
name: Active transport
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reversible: true
fast: false

metaR GALASE11ly
is described by: ECO:0000000
modifier: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
type: Reaction

metaR r0317
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR r2322
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false

metaM 3mop m
type: Species
boundary condition: false
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00491
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
initial amount: NaN

metaM ksi pre4 g
constant: false
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
has only substance units: false
is: C00130
notes: FORMULA: C101H165N7O72X CHARGE: -1
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 4
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_09629dd8_302b_4b25_bae8_4e315c4deb01
boundary condition: true
is: SBO:0000252
name: RRM1
initial concentration: NaN
constant: false
is: P23921
is encoded by: hsa:6240
type: Species
has only substance units: false
initial amount: NaN

metaM ditp c
initial amount: NaN
initial concentration: 1.0
name: dITP(4-)
constant: false
is: HMDB03537
boundary condition: false
is: SBO:0000247
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
has only substance units: false

metaM dece3coa m
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8b8d111a_0387_446f_8208_0bbaa76dbab5
is encoded by: hsa:4696
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O95167
constant: false
is: SBO:0000252
name: NDUFA3
type: Species
initial amount: NaN

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM h x
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
name: proton
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_eb77d25f_1cfe_4dd2_867d_6510f3534662
name: PAICS
type: Species
boundary condition: true
is encoded by: hsa:10606
is: P22234
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM CE2422 m
boundary condition: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
constant: false
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
initial amount: NaN

metaR r1728
is: SBO:0000185
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f7cea9fc_278a_42c0_a6fd_7bcb9a15cd17
type: Species
has only substance units: false
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:515
boundary condition: true
is: SBO:0000297
initial concentration: NaN
initial amount: NaN

metaM sebcoa x
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: sebacoylcoa
is: SBO:0000247
initial amount: NaN

metaM man c
name: D-Mannose
type: Species
is: HMDB00169
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: CHEBI:16024
is: SBO:0000247
initial concentration: 1.0
is: C00159
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c32d70a9_7cec_4772_8cd4_39b6067555e0
name: RDH14
initial amount: NaN
is: Q9HBH5
is encoded by: hsa:57665
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9edf1d10_d8d1_4bea_b376_7ab5f23ff34a
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI694761_1_c
has only substance units: false
type: Species
is encoded by: hsa:AI694761
initial amount: NaN

metaR PROSTGE2t2
kinetic law: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110015#
is described by: ECO:0000269
name: prostaglandin uniport
reversible: true
type: Reaction
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_082ea869_c98e_4671_98bd_e112d4765ee4
type: Species
initial concentration: NaN
is: SBO:0000252
name: OGDH
is encoded by: hsa:4967
constant: false
is: Q02218
initial amount: NaN
boundary condition: true
has only substance units: false

metaR FACOAL205
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR FAOXTC122m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR r1552
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM h m
has only substance units: false
name: proton
boundary condition: false
is: CHEBI:24636
initial amount: NaN
initial concentration: 1.0
is: C00080
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247

metaR IDOURtly
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
reversible: true
name: iduronate transport into lysososme
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_9606bae7_e7e8_4bbe_8dda_f33a2671136d
is: SBO:0000252
is encoded by: hsa:4952
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: OCRL
type: Species
constant: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c3c3cdd3_b745_4102_a851_f651b8e2a51d
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10797
name: MTHFD2
boundary condition: true
type: Species
constant: false
is: P13995
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_0f4ff774_c162_4f11_aa81_c24268249a67
is: SBO:0000252
boundary condition: true
constant: false
name: INPP1
has only substance units: false
is: P49441
initial concentration: NaN
type: Species
is encoded by: hsa:3628
initial amount: NaN

metaR CLPNDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a3e28bf9_f77a_41da_ba5f_f95d79b70723
is: SBO:0000252
has only substance units: false
type: Species
name: _AI656480_1_m
boundary condition: true
is encoded by: hsa:AI656480
initial amount: NaN
initial concentration: NaN
constant: false

metaM lnlccrn m
has only substance units: false
name: Linoleyl carnitine
type: Species
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
initial amount: NaN
is: HMDB06469
boundary condition: false
initial concentration: 1.0

metaR r0083
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaM orn e
type: Species
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00214
name: Ornithine
is: CHEBI:0
initial amount: NaN

metaM acgam c
is: CHEBI:17411
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
type: Species
is: HMDB00215
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_52706ada_aeb7_406b_99fc_752f0f32b5f0
type: Species
is: Q7Z364
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5153
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDE1B

http://identifiers.org/biomodels.db/MODEL1310110015#_b892ee9d_f4be_48b2_9ce8_3ed87a503846
is: SBO:0000252
constant: false
is encoded by: hsa:10841
boundary condition: true
type: Species
name: FTCD
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM h n
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: proton
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110015#_c8a90ae7_f918_4e3d_9871_d8d7fda6fc07
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AI191472_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AI191472
boundary condition: true
constant: false

metaR r1551
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

metaM hs deg16 l
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02704
initial concentration: 1.0
is: CHEBI:21338
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
name: heparan sulfate, degradation product 16
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ca339132_522c_4892_8eb9_30ff628ad3a8
name: _U37519_1_m
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:U37519

metaR FAOXC5C3x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR r1726
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR r0208
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110015#
reversible: true
type: Reaction
product: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_f27398d2_75ca_4833_9247_c3d84b4a68b1
constant: false
has part: A8K7W0
type: Species
has only substance units: false
is encoded by: hsa:8876
is encoded by: hsa:8875
is: SBO:0000297
is encoded by: hsa:55350
has part: O95497
boundary condition: true
name: VNN3:VNN2:VNN1
initial amount: NaN
initial concentration: NaN

metaM oxa m
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: oxalate(2-)
type: Species
constant: false
boundary condition: false
is: HMDB02329
has only substance units: false

metaR CYTK4n
modifier: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_8fc8a11f_a458_4ff9_acf7_49a0f54388e4
is: Q9NQR4
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: NIT2
type: Species
is encoded by: hsa:56954

metaR 34DHOXPEGt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#

metaR r1554
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ditp n
name: dITP(4-)
is: CHEBI:61382
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR AHCYSte
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
fast: false
name: Transport of S-adenosyl-L-homocysteine

metaM ksi deg27 l
initial concentration: 1.0
is: HMDB00143
has only substance units: false
type: Species
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: SBO:0000247
name: keratan sulfate I, degradation product 27
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:12936

metaM fru e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00660
is: CHEBI:15824
boundary condition: false
constant: false
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095

metaR 4NPHte
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110015#
name: xenobiotic transport
fast: false
type: Reaction
is: SBO:0000185

metaR DDPGAm
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD

metaR r1725
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#

metaM fru c
has only substance units: false
boundary condition: false
is: HMDB00660
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: D-Fructose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: CHEBI:15824
is: C00095
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_09bd812b_8033_4736_b247_90ec2af9f316
initial amount: NaN
constant: false
boundary condition: true
is: P26572
is: SBO:0000252
name: MGAT1
is encoded by: hsa:4245
type: Species
has only substance units: false
initial concentration: NaN

metaM mi1p D c
type: Species
is: HMDB02985
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58433
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0

metaM dad 2 e
boundary condition: false
is: CHEBI:17256
name: 2-deoxyadenosine
is: SBO:0000247
is: HMDB00101
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0

metaR CSNATer
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
type: Reaction
reversible: true
product: MODEL1310110015#
is described by: ECO:0000254
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: carnitine O-acetyltransferase, endolasmic reticulum

metaM h l
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
name: proton
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
boundary condition: false

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
fast: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM hs deg21 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
is: CHEBI:16126
constant: false
is: SBO:0000247

metaM dlnlcg e
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:53486

metaR RTOTALFATPc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR GALASE1ly
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000

metaR AHCYStd
is: SBO:0000185
is described by: ECO:0000134
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110015#
name: diffusion of S-Adenosyl-L-homocysteine
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_4bef551f_284c_4886_9b96_51ffdb01e78c
is: SBO:0000252
initial amount: NaN
name: SLC26A6
initial concentration: NaN
is encoded by: hsa:65010
has only substance units: false
is: Q9NQU1
constant: false
type: Species
boundary condition: true

metaR r1553
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
fast: false

metaM dec47dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR r1010
reversible: true
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_a2738da4_2c44_4068_8bbd_2d27f9533692
boundary condition: true
has only substance units: false
name: CPT1A
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1374
is: Q8WZ48
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9fe03af1_d97c_486b_acf4_4997a55c91bd
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI373818
initial amount: NaN
constant: false
name: _AI373818_1_m
has only substance units: false
initial concentration: NaN
type: Species

metaR GPIDAer
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
type: Reaction
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
is: SBO:0000176
reversible: false
reactant: MODEL1310110015#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_adcb7f17_feb3_42b2_9bcd_aa30cfb02dfa
initial amount: NaN
has only substance units: false
is encoded by: hsa:728226
type: Species
constant: false
name: _728226_1_m
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r0311
is: SBO:0000176
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
kinetic law: MODEL1310110015#

metaR r1556
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
fast: false

metaR r0086
modifier: MODEL1310110015#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110015#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.4.1.4
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_fb4e99da_a82e_4ae1_aaa0_0823100dff47
is encoded by: hsa:2588
has part: P34059
has part: Q99519
has part: P16278
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2720
has only substance units: false
type: Species
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN
is: SBO:0000297
has part: P10619
is encoded by: hsa:5476
is encoded by: hsa:4758

metaM for r
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
name: Formate
is: SBO:0000247
type: Species
is: HMDB00142
boundary condition: false
initial amount: NaN
is: C00058
has only substance units: false
initial concentration: 1.0
is: CHEBI:15740

metaM msa m
initial amount: NaN
is: HMDB11111
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
type: Species
name: 3-oxopropanoate
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:33190

metaM dad 2 c
name: 2-deoxyadenosine
is: SBO:0000247
has only substance units: false
is: CHEBI:17256
is: HMDB00101
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

metaR GCCcm
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoylprotein), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110015#_9b5e520c_e0a2_4c9f_bd6f_d2fbcee34d0b
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: PIGA
is encoded by: hsa:5277
initial amount: NaN
is: B3KUV7
initial concentration: NaN
constant: false

metaR r0715
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110015#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110015#

metaR SERt4
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
is: SBO:0000185
reversible: false
product: MODEL1310110015#
name: L-serine via sodium symport
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaM ser D e
initial amount: NaN
has only substance units: false
is: HMDB03406
is: CHEBI:16523
type: Species
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
initial concentration: 1.0
name: D-serine
is: SBO:0000247

metaR RE2814M
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
name: RE2814
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#

metaM h r
is: SBO:0000247
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
is: C00080
type: Species
constant: false
has only substance units: false
name: proton
initial amount: NaN

metaM ac c
initial concentration: 1.0
name: acetate
is: HMDB00042
has only substance units: false
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_de325385_58b4_42eb_b8ce_4af38273be40
is: SBO:0000252
name: _AI926493_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI926493
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM dlnlcg c
is: CHEBI:53486
initial amount: NaN
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: SBO:0000247
constant: false

metaR PALFATPtc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR FMNAT
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
is: SBO:0000176
name: FMN adenylyltransferase
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.2

metaR GALASE16ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
type: Reaction
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR DM datp m
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dATP demand
type: Reaction

metaR ENGASE2ly
is: SBO:0000176
product: MODEL1310110015#
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction

metaR SUCCTD
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM C05279 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
constant: false
is: CHEBI:28387
is: HMDB11123
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial concentration: 1.0

metaR PPNCL3
reversible: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.2.5
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: phosphopantothenate-cysteine ligase
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_5652f29b_a736_4675_9ab8_1fe9dcee3344
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9BZX2
initial amount: NaN
boundary condition: true
constant: false
name: UCK2
is encoded by: hsa:7371
has only substance units: false

metaM ksi pre23 g
has only substance units: false
is: CHEBI:28067
constant: false
initial amount: NaN
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 23
type: Species

metaR RE2954C
name: RE2954
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110015#

metaM 20ahchsterol m
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:1296
initial amount: NaN
name: 20-hydroxycholesterol

metaR RE2799C
reactant: MODEL1310110015#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000
name: RE2799
is: SBO:0000176
product: MODEL1310110015#

metaM xoltetrol c
is: SBO:0000247
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
initial amount: NaN
type: Species
is: HMDB01231
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
boundary condition: false
initial concentration: 1.0
is: CHEBI:17278

metaM phe L c
boundary condition: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
type: Species
constant: false
name: L-phenylalanine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17295

metaR r1557
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM cpppg3 c
is: CHEBI:57309
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
type: Species
has only substance units: false
is: HMDB01261
name: Coproporphyrinogen III
is: SBO:0000247
is: C03263

metaM orn c
is: C01602
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00214
constant: false
name: Ornithine
boundary condition: false
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR C14STRr
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
fast: false
is: SBO:0000176
reversible: false
name: C-14 sterol reductase
kinetic law: MODEL1310110015#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_e5d98183_2512_427b_96af_4abd5a68d056
name: PPCDC
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q96CD2
type: Species
is encoded by: hsa:60490

metaR CLPNDt
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110015#_7946a0f6_c28e_4e34_9fb3_a79aadf41c38
is encoded by: hsa:6647
is: SBO:0000252
boundary condition: true
name: SOD1
is: P00441
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_682fb0a8_0467_4c00_a37f_4712c998165d
is encoded by: hsa:478
is: B7Z2T0
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: ATP1A3
type: Species
initial concentration: NaN

metaM ksi pre14 g
name: keratan sulfate I biosynthesis, precursor 14
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5769b167_b062_4b4b_942f_80f708b0c177
has only substance units: false
name: _AA278423_1_c
boundary condition: true
is encoded by: hsa:AA278423
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM phe L e
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17295
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
has only substance units: false
type: Species

metaM btamp m
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
boundary condition: false
is: CHEBI:3110
is: HMDB04220
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_7779a785_8c55_4058_80c7_661bae776bc9
initial amount: NaN
name: GALNT14
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79623
has only substance units: false
is: Q96FL9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_4208aea2_c1f1_45fc_8cb7_716120b12d61
initial amount: NaN
is encoded by: hsa:3141
is: P50747
is: SBO:0000252
name: HLCS
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR r1008
reversible: false
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM thexddcoa m
has only substance units: false
is: SBO:0000247
type: Species
name: trans7,10-hexadecadienoylcoa
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
boundary condition: false

metaM chlstol r
constant: false
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: HMDB06842
is: SBO:0000247
initial amount: NaN
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial concentration: 1.0
has only substance units: false
type: Species

metaR FAOXC181C161x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_dca84b7f_c484_47f3_8f05_4628c98ae56e
is: P46459
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NSF
is encoded by: hsa:4905
type: Species
constant: false
is: SBO:0000252

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c83eb2c0_da75_4414_b427_339cf3e8149e
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2109
name: ETFB
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_fd31cf62_eb67_4f91_949e_cbeaeb7a60d8
is encoded by: hsa:2686
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: GGT7
boundary condition: true
is: A0PJJ9
is: SBO:0000252
constant: false

metaM sbt D c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
type: Species
constant: false
is: SBO:0000247
name: D-glucitol
is: HMDB00247

metaR PEPCKm
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.32
modifier: MODEL1310110015#
is described by: ECO:0000000
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR FACOAL200
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000269

metaR RE3301C
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110015#
name: RE3301
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ce5ab999_bca4_47f3_a387_5f6b5b2d42cd
name: PIGX:PIGM
constant: false
is encoded by: hsa:93183
has part: Q8TBF5
initial concentration: NaN
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:54965
type: Species
has part: Q9H3S5
has only substance units: false

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_00cb6525_b6d6_41f1_8b5d_5ef68e13abc7
is: P46721
is encoded by: hsa:6579
constant: false
has only substance units: false
name: SLCO1A2
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR PYDAMtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
name: pyridoxamine transport via diffusion
kinetic law: MODEL1310110015#
fast: false
type: Reaction
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is described by: ECO:0000000

metaR SARDHm
kinetic law: MODEL1310110015#
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110015#
name: Sarcosine dehydrogenase (m)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.99.1

metaR UROLACer
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
reversible: true
name: uronolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD

metaM man l
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: D-mannose
is: HMDB00169
is: CHEBI:16024

metaM ksi deg8 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: CHEBI:12936
has only substance units: false
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_28797894_fc5a_4e8c_82c8_01b478796d69
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC8A3
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6547

metaR r1007
kinetic law: MODEL1310110015#
reversible: true
name: Facilitated diffusion
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

metaR SERHL
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
name: L-Serine hydro-lyase
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM

metaM ocdececrn m
name: 11-octadecenoyl carnitine
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_c641c161_0579_4323_ab0e_5c3ff7aa6e11
initial concentration: NaN
is encoded by: hsa:51227
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PIGP
constant: false
is: P57054
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_512e2fbc_6b24_4847_9f93_85660cff77ca
is: SBO:0000252
name: LDHAL6A
is encoded by: hsa:160287
constant: false
boundary condition: true
is: Q6ZMR3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM sbt D e
name: D-glucitol
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: HMDB00247

metaM glu5p m
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
type: Species
is: CHEBI:58274
initial concentration: 1.0
name: L-Glutamate 5-phosphate
is: HMDB01228
initial amount: NaN
constant: false

metaM thcholstoic x
boundary condition: false
constant: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_2a84aebb_53ae_4f23_b910_94c71be0d065
constant: false
name: DGAT1
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: O75907
is encoded by: hsa:8694
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_f079ed57_a789_4f6c_93e9_51d9b1fdd6ef
is: SBO:0000252
name: ENPP3
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5169
is: Q308M7
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_0e45dbc4_0d0e_4636_880f_193e7ac17f36
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AF116616
initial concentration: NaN
name: _AF116616_1_m
boundary condition: true
constant: false
is: SBO:0000252

metaR VD3
name: Vitamin D3 formation
reversible: true
fast: false
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000134

metaR LPCOXp
name: L-pipecolate oxidase, peroxisomal
reversible: false
is version of: http://identifiers.org/ec-code/1.5.3.1
is described by: ECO:0000269
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ab608481_1840_4cba_9e63_e28895554948
name: ITPKA
initial concentration: NaN
constant: false
is encoded by: hsa:3706
boundary condition: true
type: Species
is: SBO:0000252
is: P23677
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_fa3c2e21_fd66_4023_9ef7_eee78ad1344a
is encoded by: hsa:9091
is: SBO:0000297
is encoded by: hsa:5277
initial amount: NaN
constant: false
has part: P57054
initial concentration: NaN
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
is encoded by: hsa:51227
has part: B2RAU6
has only substance units: false
is encoded by: hsa:5279

metaM C05280 m
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
is: CHEBI:28002
initial amount: NaN
constant: false
is: HMDB03952
name: cis,cis-3,6-Dodecadienoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_4444039f_9e17_417a_b6be_14ef21f2e102
is encoded by: hsa:2271
constant: false
name: FH
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: P07954
initial concentration: NaN
has only substance units: false

metaM dolmanp L c
type: Species
boundary condition: false
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:15809

http://identifiers.org/biomodels.db/MODEL1310110015#_f02c2d8d_ad29_4221_a3a1_4b21f3d280c0
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: P05091
name: ALDH2
is encoded by: hsa:217
has only substance units: false
boundary condition: true

metaR RE0344C
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0344
reversible: true
is: SBO:0000176
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_0565a90a_53e6_4d04_917d_3d2fc2e6511f
is: SBO:0000252
is encoded by: hsa:7372
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: A8K5J1
name: UMPS

http://identifiers.org/biomodels.db/MODEL1310110015#_c9a865d1_78eb_4994_9e5a_9b1c9b4d6803
is: Q8NBL9
name: PIGS
is encoded by: hsa:94005
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM tdcoa m
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
is: C02593
constant: false
initial amount: NaN

metaR FAOXC164C165m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_2fb5f669_8ec9_4845_8d3d_67a5ae574237
is: Q9C0J1
has only substance units: false
name: B3GNT4
constant: false
type: Species
is encoded by: hsa:79369
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM Nacasp c
is: HMDB00812
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
type: Species
is: CHEBI:16953
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: N-acetyl-L-aspartate(2-)
initial amount: NaN
is: SBO:0000247

metaR r1560
reactant: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#

metaR OIVD1m
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176

metaR r2408
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: false
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_7edc1498_20e2_4a9c_ac03_6c86558d44c5
boundary condition: true
is: SBO:0000252
is: O95168
initial concentration: NaN
has only substance units: false
name: NDUFB4
type: Species
is encoded by: hsa:4710
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_535b6baf_155a_46cb_9bd7_011012dd9bf8
name: SLC23A2
initial amount: NaN
is encoded by: hsa:9962
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaR CYTK3n
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
name: cytidylate kinase (dCMP,CTP),nuclear
reversible: true

metaR RE2626M
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2626
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#

metaM m2emgacpail hs r
has only substance units: false
is: CHEBI:24636
initial concentration: 1.0
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380

metaM man g
is: CHEBI:16024
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-mannose
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00169
type: Species
initial amount: NaN

metaR r1561
is: SBO:0000185
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaR BTNtn
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is described by: ECO:0000000
name: Biotin transport, nuclear
kinetic law: MODEL1310110015#
fast: false
type: Reaction
product: MODEL1310110015#
reversible: true
is: SBO:0000185

metaM methf c
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
name: 5,10-Methenyltetrahydrofolate
is: CHEBI:57455
type: Species
initial amount: NaN
is: HMDB01354
is: C00445

http://identifiers.org/biomodels.db/MODEL1310110015#_e4d2d1e1_a477_4ba5_96d0_9e0ea2e7c6d7
name: GALNT10
has only substance units: false
initial amount: NaN
is: Q86SR1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55568
boundary condition: true

metaR FACOAL204
fast: false
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT

metaR RE1233C
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
name: RE1233
reactant: MODEL1310110015#
type: Reaction

metaR r0081
reversible: true
product: MODEL1310110015#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:

metaR S6TASE22ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal

metaR GLCAASE1ly
fast: false
product: MODEL1310110015#
is: SBO:0000176
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_0bf10208_5151_4506_8fce_65913a609cb3
has only substance units: false
is encoded by: hsa:8402
name: SLC25A11
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: F5GY65
is: SBO:0000252

metaR PETHCT
kinetic law: MODEL1310110015#
name: phosphoethanolamine cytidyltransferase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.14
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM coa c
initial amount: NaN
name: Coenzyme A
is: C00010
initial concentration: 1.0
is: SBO:0000247
is: HMDB01423
has only substance units: false
is: CHEBI:3312
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
boundary condition: false
type: Species
constant: false

metaR CSEPASEly
type: Reaction
fast: false
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_b518b847_d934_415e_ba97_b1e95e2f1fb9
initial amount: NaN
initial concentration: NaN
constant: false
name: RPIA
is: P49247
type: Species
is: SBO:0000252
is encoded by: hsa:22934
boundary condition: true
has only substance units: false

metaM CE2418 m
type: Species
initial concentration: 1.0
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
is: CHEBI:28387
is: HMDB11123
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418

metaR r1722
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reversible: false

metaR r1562
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR UGT1A10r
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
is: SBO:0000176
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
is described by: ECO:0000134

metaR FACOAL203
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110015#
name: fatty-acid--CoA ligase
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0f5220b1_5cd8_4917_b862_e4012c2bb89c
is: Q5JWV8
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2182
constant: false
name: ACSL4

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110015#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110015#_fd6f4796_6163_423f_b5e0_425bd4e4104d
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: P19623
name: SRM
type: Species
is encoded by: hsa:6723

http://identifiers.org/biomodels.db/MODEL1310110015#_661a90d5_682f_4d96_91b9_621cb3c269d5
is: Q16850
has only substance units: false
boundary condition: true
is encoded by: hsa:1595
constant: false
name: CYP51A1
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR DNDPt27m
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: dCDP transport via dTDP antiport
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reactant: MODEL1310110015#
reversible: false
is described by: ECO:0000269

metaM g3p c
is: HMDB01112
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3930
type: Species
name: Glyceraldehyde 3-phosphate
is: SBO:0000247
is: CHEBI:58027
is: C00661
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_766a4e5f_601b_4e00_bc64_bab5ba5eda0d
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q02742
is encoded by: hsa:2650
type: Species
name: GCNT1

metaR SPMTDe
name: SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_aa0e9ea0_d84f_4568_a4ce_81f078643774
is: E9KL44
initial amount: NaN
is encoded by: hsa:3030
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: HADHA

metaR BMTer L
kinetic law: MODEL1310110015#
reversible: false
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
name: B mannosyltransferase, endoplasmic reticulum
product: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_d2b73801_05dc_4bc1_bd25_e495de8a1471
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q7GXZ8
name: COX2
constant: false
is encoded by: hsa:4513
is: SBO:0000252
initial amount: NaN
type: Species

metaR r2316
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110015#
is: SBO:0000185

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17272
is: HMDB00237
type: Species
name: propionate
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaR r2102
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185

metaR DCK2n
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
product: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#

metaR 3AIBTm
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110015#
reversible: true
name: L-3-aminoisobutyrate transaminase, mitochondrial
is described by: ECO:0000304
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110015#

metaR LEUTA
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

metaM acgam r
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
is: CHEBI:17411
type: Species
boundary condition: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
initial amount: NaN
is: HMDB00215
constant: false

metaR r2404
reversible: false
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_a2b976ac_b93c_4db7_a7f3_380abe5bdc25
type: Species
name: FDFT1
boundary condition: true
is: SBO:0000252
is: P37268
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2222
initial amount: NaN

metaR 3MOBte
type: Reaction
reversible: true
is: SBO:0000185
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR r2315
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110015#
reversible: true
fast: false
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR r2101
modifier: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
type: Reaction

metaR UGLT
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5f1f510f_60fd_42e7_b736_e569ae1cd5ae
has part: P27986
name: PIK3CA:PIK3R1
is: SBO:0000297
is encoded by: hsa:5295
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaM ocdececrn c
constant: false
name: 11-octadecenoyl carnitine
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
type: Species
is: HMDB06351

metaR FE2tm
fast: false
is: SBO:0000185
name: iron (II) transport
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false

metaM tettet6 c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: tetracosatetraenoic acid n-6
is: HMDB06246

metaM docohexcoa m
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110015#_f894dee3_0686_422a_af0b_f3ecca9248bc
has only substance units: false
initial amount: NaN
name: _BF195998_1_x
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BF195998
type: Species

metaM btamp c
is: SBO:0000247
is: HMDB04220
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
name: Biotinyl-5'-AMP
constant: false
initial concentration: 1.0
is: CHEBI:3110

metaR IDOAASE2ly
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
reversible: false

metaR CYTDt
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
name: cytidine facilated transport in cytosol
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
fast: false
is described by: ECO:0000269

metaR r2100
is: SBO:0000185
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r2314
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110015#
fast: false

metaR APOCF
name: Apocarboxylase formation
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: false
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1df884ce_8a1e_41a4_9deb_27206174f037
is encoded by: hsa:55350
initial concentration: NaN
name: VNN3:VNN2:VNN1
constant: false
type: Species
is: SBO:0000297
boundary condition: true
initial amount: NaN
has only substance units: false

metaR HMGCOASim
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269

metaR r1831
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

metaR r1453
is: SBO:0000176
kinetic law: MODEL1310110015#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
fast: false
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110015#
type: Reaction

metaR DM anth
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR r2313
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110015#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM 44mctr r
constant: false
boundary condition: false
is: CHEBI:17813
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial amount: NaN
is: HMDB01023

metaR RE3014R
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8529.1) or (4051.1) or (126410.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.13.30 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.30
name: RE3014
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction

metaR r2401
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110015#
reversible: false
fast: false
product: MODEL1310110015#

metaM 3mop c
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00491
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
initial amount: NaN
is: CHEBI:28654
type: Species

metaM Nacasp m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
type: Species
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: HMDB00812
constant: false
boundary condition: false

metaR ABTArm
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110015#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
modifier: MODEL1310110015#

metaR S6T15g
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21
modifier: MODEL1310110015#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110015#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR MMSAD1m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
reactant: MODEL1310110015#
name: methylmalonate-semialdehyde dehydrogenase
product: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false

metaR SAMHISTA
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
reversible: false
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.1.8

metaR r2106
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
fast: false
reversible: true
type: Reaction

metaR r0860
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
type: Reaction
is: SBO:0000185
name: Utilized transport
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
kinetic law: MODEL1310110015#

metaR r1117
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

metaM 5mta c
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: HMDB01173
is: SBO:0000247
type: Species
boundary condition: false
is: C00170
constant: false
initial amount: NaN
initial concentration: 1.0
name: 5-Methylthioadenosine
is: CHEBI:17509

metaR GTHRDt
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
fast: false
product: MODEL1310110015#
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaR CREATt4 2 r
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
name: Creatine transport (sodium symport) (2:1)

metaR F1PGT
is version of: http://identifiers.org/ec-code/2.7.7.30
name: fucose-1-phosphate guanylyltransferase
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaM ksi deg2 l
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 2
type: Species
is: SBO:0000247
is: CHEBI:30825
boundary condition: false
initial amount: NaN
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: HMDB00573

metaR r2319
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR SERGLYexR
reactant: MODEL1310110015#
name: L-Serine/Glycine reversible exchange
product: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR S6TASE18ly
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaR r2105
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110015#

metaR CERT2gt
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000185
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM thcholstoic m
is: HMDB03873
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_766994b5_4d60_4ac9_8a53_dd8464e78731
is encoded by: hsa:9962
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: SLC23A2
initial amount: NaN
is: Q9UGH3
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b5d3516e_86b7_42c7_b4fb_7470a13e48fb
is: SBO:0000252
initial amount: NaN
name: INPP4B
is encoded by: hsa:8821
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: O15327
constant: false

metaR CERT1rt
reactant: MODEL1310110015#
name: ceramide transport protein
type: Reaction
is: SBO:0000185
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110015#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110015#
is described by: ECO:0000304

metaR r2318
kinetic law: MODEL1310110015#
fast: false
type: Reaction
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_93da40d7_0dc3_483e_89f6_16296baed713
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q99808
initial concentration: NaN
is encoded by: hsa:2030
constant: false
is: SBO:0000252
type: Species
name: SLC29A1

http://identifiers.org/biomodels.db/MODEL1310110015#_6183767b_d44c_42a3_afc6_789823eadb1d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: MCCC1
has only substance units: false
is encoded by: hsa:56922
constant: false
is: Q96RQ3
initial amount: NaN
type: Species

metaR r2104
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110015#_c367a426_1aad_4e96_9672_bf5507a936de
has only substance units: false
is: SBO:0000252
name: B4GALT2
initial amount: NaN
constant: false
is encoded by: hsa:8704
type: Species
initial concentration: NaN
boundary condition: true

metaR RE2626C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110015#
name: RE2626
kinetic law: MODEL1310110015#
fast: false

metaM ppa c
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
constant: false
name: propionate
type: Species
initial amount: NaN
is: HMDB00237
boundary condition: false
is: CHEBI:17272
initial concentration: 1.0

metaM 5mta e
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: SBO:0000247
has only substance units: false
is: HMDB01173
type: Species
constant: false
initial amount: NaN
is: C00170
boundary condition: false
initial concentration: 1.0
name: 5-Methylthioadenosine
is: CHEBI:17509

metaR GLUDym
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: glutamate dehydrogenase (NADP), mitochondrial
kinetic law: MODEL1310110015#

metaR r2317
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false

metaM acgam l
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00215
boundary condition: false
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: SBO:0000247

metaR AG13T15g
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110015#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM thbpt c
has only substance units: false
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247
is: HMDB00027
is: CHEBI:15372
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR DM n5m2masn g
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM n5m2masn(g)
type: Reaction

metaR r2103
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#

metaM 5dpmev x
is: CHEBI:15899
boundary condition: false
initial amount: NaN
is: HMDB01090
is: SBO:0000247
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
has only substance units: false
constant: false

metaM tdcoa x
is: C02593
initial concentration: 1.0
type: Species
is: CHEBI:57385
initial amount: NaN
constant: false
is: HMDB01521
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247

metaR r1116
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
is: SBO:0000185

metaR AMETt2m
kinetic law: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true

metaM coa n
type: Species
name: coenzyme A(4-)
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57287
is: HMDB01423
boundary condition: false

metaM fe2 c
has only substance units: false
initial concentration: 1.0
name: Fe2+
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: C00023
is: CHEBI:29033
is: HMDB00692

metaR SPHK21c
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
kinetic law: MODEL1310110015#
fast: false
type: Reaction
product: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.91
name: sphingosine kinase 2
modifier: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269

metaR PNTK
reactant: MODEL1310110015#
name: pantothenate kinase
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110015#

metaM hs deg17 l
name: heparan sulfate, degradation product 17
is: CHEBI:21338
is: HMDB02704
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H65N2O48S4 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110015#_abca15f8_0ea3_48d0_9ca1_40dee1a50507
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:52
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P24666
initial amount: NaN
name: ACP1

metaR r2107
modifier: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a787520d_3160_4830_8d49_03d7c86470b7
type: Species
is encoded by: hsa:5277
name: PIGA
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_11788b80_0500_48ef_bcfe_934de6a6fc54
is: P43166
is encoded by: hsa:766
name: CA7
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM thymd c
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17748
is: C00214
constant: false
has only substance units: false
boundary condition: false
is: HMDB00273
name: Thymidine
type: Species

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM 5oxpro c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57606
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
type: Species
initial concentration: 1.0
is: HMDB00267
has only substance units: false
constant: false

metaM cmpacna g
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812

metaR GALGLUSIDEtg
reactant: MODEL1310110015#
name: galgluside hs intracellular transport
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
fast: false
type: Reaction

metaM 4hexdtricoa m
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
type: Species
is: HMDB02288
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_c9329743_a6da_4cdc_9fa5_05f7df8da7c0
initial concentration: NaN
type: Species
is: A4D1D5
initial amount: NaN
constant: false
name: ABCB4
boundary condition: true
is encoded by: hsa:5244
has only substance units: false
is: SBO:0000252

metaR r0186
fast: false
reactant: MODEL1310110015#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176

metaR r2330
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM ksii core2 pre3 g
initial concentration: 1.0
is: HMDB00175
constant: false
is: CHEBI:58053
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 3
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
is: C00130
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_af9bbc0f_dd6d_4568_b114_680631f2063c
initial concentration: NaN
is encoded by: hsa:27068
is: SBO:0000252
name: PPA2
type: Species
constant: false
has only substance units: false
is: F8WDN9
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_9ebb88e0_43b3_4ae3_8b34_5580c3d654b7
is: SBO:0000252
has only substance units: false
boundary condition: true
name: BCAT1
constant: false
initial concentration: NaN
is: P54687
type: Species
initial amount: NaN
is encoded by: hsa:586

http://identifiers.org/biomodels.db/MODEL1310110015#_9bed8a7a_2697_40c1_85d9_83a8c262e33d
name: PDE7B
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27115
type: Species
is: SBO:0000252
is: Q9NP56
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_71ce3eab_e207_4117_88c0_8d51c3f1a2c3
boundary condition: true
is: SBO:0000252
is: Q5JAM2
name: ALAS1
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:211

metaR r2108
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5c61d514_6999_4cdb_b16a_20013a24c608
type: Species
constant: false
initial concentration: NaN
is: P23786
boundary condition: true
name: CPT2
has only substance units: false
initial amount: NaN
is encoded by: hsa:1376
is: SBO:0000252

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_0271f3e6_a5f4_4e0f_8b63_6519fef95490
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: _H77542_1_r
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:H77542

metaM met L e
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00696
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
name: L-methionine

metaR S23T2g
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

metaR LEUKTRA4tr
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
name: leukotriene intracellular transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR LDH D
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reversible: true
product: MODEL1310110015#
fast: false
is described by: ECO:0000304
name: D-lactate dehydrogenase
modifier: MODEL1310110015#
type: Reaction

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR r2420
product: MODEL1310110015#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true

metaR S6T4g
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110015#_ad00d620_f90d_43d3_8881_e3ac2a365457
is encoded by: hsa:112724
name: RDH13
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B3KVA3
boundary condition: true
type: Species

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
initial amount: NaN
type: Species
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
is: HMDB00175
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaM dcsptn1crn m
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
constant: false
is: HMDB06321
initial concentration: 1.0

metaR r1459
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
name: Transport reaction

metaR CYANtm
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_5f050cd3_303f_4fe7_8e9b_3e4f50ab63ae
type: Species
constant: false
initial concentration: NaN
name: IDI2
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:91734
is: SBO:0000252
is: Q9BXS1

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_477af833_6cc4_4a57_b370_9ced3a0bb201
type: Species
is: SBO:0000252
is: Q308M7
boundary condition: true
initial amount: NaN
is encoded by: hsa:5169
name: ENPP3
initial concentration: NaN
has only substance units: false
constant: false

metaR r2332
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_9f8fb9cc_db2d_4af5_b63d_343869a520ec
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6470
type: Species
boundary condition: true
is: SBO:0000252
is: P34896
has only substance units: false
constant: false
name: SHMT1

metaM C05965 e
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
is: SBO:0000247
name: 12(S)-HPETE(1-)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB04243
is: CHEBI:57444

metaM methf m
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57455
constant: false
is: HMDB01354
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
name: (6R)-5,10-methenyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110015#_e0456cf0_424a_4e04_88bc_b2aed03a8edc
is encoded by: hsa:217
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: ALDH2
initial amount: NaN
is: P05091
type: Species

metaR RE0827E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE0827
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaM ksi deg31 l
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953
type: Species
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 31
has only substance units: false
is: HMDB00812

http://identifiers.org/biomodels.db/MODEL1310110015#_dea6afeb_6a9d_4517_b4ce_58e8027e64b6
is: B4DP47
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:593
initial amount: NaN
boundary condition: true
name: BCKDHA

http://identifiers.org/biomodels.db/MODEL1310110015#_3a03c9bb_10a7_40ab_8054_9ee0bc1e82de
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI935189
type: Species
name: _AI935189_1_m
boundary condition: true
initial concentration: NaN

metaR GALASE17ly
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110015#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM met L c
is: CHEBI:16643
is: HMDB00696
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
name: L-methionine
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_ee535dcb_ba7b_4482_9bb4_638c2906e019
is: SBO:0000252
is: E7EPT3
type: Species
initial concentration: NaN
is encoded by: hsa:501
initial amount: NaN
name: ALDH7A1
has only substance units: false
constant: false
boundary condition: true

metaM retinal cis 13 r
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
constant: false
initial concentration: 1.0
type: Species
is: HMDB06220
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_f2577145_89b6_4631_a43d_aeeea4da11fd
is: SBO:0000252
initial concentration: NaN
name: SLC24A4
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:123041

metaR C3STDH1r
reversible: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110015#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM coa r
initial amount: NaN
type: Species
has only substance units: false
name: Coenzyme A
is: HMDB01423
initial concentration: 1.0
constant: false
is: CHEBI:57287
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: SBO:0000247

metaR r0181
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
product: MODEL1310110015#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_7ce84df2_a9b6_48b4_bce2_4e70d0860cb4
is: F8W1L5
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GPD1
type: Species
is encoded by: hsa:2819
initial amount: NaN

metaM cmpacna c
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57812
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
boundary condition: false
is: SBO:0000247

metaR r0879
product: MODEL1310110015#
reversible: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f166d9e6_84d9_425e_af00_99c760e96779
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI640625
initial concentration: NaN
is: SBO:0000252
name: _AI640625_1_c
initial amount: NaN
type: Species

metaR DHCRD2
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: false
modifier: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
name: dihydroceramide desaturase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110015#_5d6e0753_263e_4947_b7e9_4522aeb7bbd7
is: P21108
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: PRPS1L1
boundary condition: true
initial amount: NaN
is encoded by: hsa:221823

metaR GLCtly
is described by: ECO:0000000
name: glucose efflux from lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR r0932
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
type: Reaction
reactant: MODEL1310110015#

metaM pheme c
boundary condition: false
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
is: SBO:0000247
has only substance units: false
name: Protoheme
initial concentration: 1.0
is: HMDB03178
type: Species
is: CHEBI:17627
initial amount: NaN

metaR GALGLUSIDEtl
name: galgluside hs intracellular transport
product: MODEL1310110015#
fast: false
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true

metaM clpndcoa x
boundary condition: false
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06267
type: Species
is: C16166

metaR r0652
is described by: ECO:0000000
type: Reaction
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110015#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110015#

metaR r2334
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaR CYSGLTH
reversible: true
product: MODEL1310110015#
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_5dd8e27d_7421_490c_a079_16547779dc45
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA526438
constant: false
type: Species
name: _AA526438_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM o2 c
initial concentration: 1.0
name: O2
is: C00007
is: SBO:0000247
constant: false
is: CHEBI:15379
has only substance units: false
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
boundary condition: false
initial amount: NaN

metaR C10DCCACT
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_d77cb7ec_f0f9_4272_ba44_860f03c1eea5
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51095
constant: false
boundary condition: true
initial amount: NaN
name: TRNT1
is: Q96Q11

metaM ibcoa m
name: isobutyryl-CoA(4-)
type: Species
is: CHEBI:57338
is: HMDB01243
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR ATPH2e
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110015#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
name: ATP diphosphohydrolase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176

metaR r0931
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
reversible: false
is described by: ECO:0000000
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_50d9881b_7084_444b_951a_c99444a1410a
boundary condition: true
is encoded by: hsa:D87002
name: _D87002_1_e
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR r0655
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10

metaR FAOXC184C164m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM tcynt e
boundary condition: false
name: thiocyanate
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
constant: false
is: CHEBI:18022
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM Lpipecol x
boundary condition: false
constant: false
name: L-pipecolic acid
initial amount: NaN
has only substance units: false
is: HMDB00716
is: CHEBI:30913
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_689ca0a9_857f_4eae_87ab_c76ea820c0f2
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:54965
constant: false
initial concentration: NaN
name: PIGX
type: Species
is: Q8TBF5
is: SBO:0000252

metaM omhdecacid c
is: SBO:0000247
notes: FORMULA: C10H19O3 CHARGE: -1
constant: false
name: w-hydroxydecanoicacid
type: Species
has only substance units: false
boundary condition: false
is: HMDB12969
initial concentration: 1.0
initial amount: NaN

metaR ILETA
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
reversible: true
name: isoleucine transaminase
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaM f1p c
is: C01094
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
type: Species
initial amount: NaN
has only substance units: false
name: D-Fructose 1-phosphate
is: CHEBI:18105
is: HMDB01076
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM tettet6 e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06246
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
initial amount: NaN
type: Species
name: tetracosatetraenoic acid n-6
constant: false
has only substance units: false

metaM 5oxpro e
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57606
name: 5-oxoprolinate
initial concentration: 1.0
constant: false
is: HMDB00267
boundary condition: false
has only substance units: false

metaR r1020
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
name: Postulated transport reaction
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_2ec6a236_dee5_4da9_839a_32ce4a363913
has only substance units: false
name: HSD3B1
is: SBO:0000252
initial concentration: NaN
is: P14060
constant: false
type: Species
boundary condition: true
is encoded by: hsa:3283
initial amount: NaN

metaR r1454
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction

metaM pheme e
type: Species
has only substance units: false
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
constant: false
is: SBO:0000247
name: Protoheme
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03178

metaR DCSPTN1COAtx
reactant: MODEL1310110015#
fast: false
name: fatty acid intracellular transport
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110015#

metaM 4mptnl e
is: CHEBI:17998
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
name: 4-methylpentanal
boundary condition: false
initial amount: NaN
is: HMDB01318
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_54428b09_9245_4d10_91ab_9b7cb6a0b965
is: O76062
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:7108
name: TM7SF2

metaR NDP10ex
modifier: MODEL1310110015#
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
name: nucleoside-diphosphatase (IDP), extracellular
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
kinetic law: MODEL1310110015#

metaM acnam l
is: CHEBI:35418
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: N-acetylneuraminate
initial concentration: 1.0
is: HMDB00230
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false

metaR r0936
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: Transport reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reversible: false
fast: false

metaM tcynt c
is: HMDB01453
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0
is: CHEBI:18022
constant: false
initial amount: NaN
boundary condition: false
name: thiocyanate
is: SBO:0000247
has only substance units: false

metaM prostge1 c
initial concentration: 1.0
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01442
is: CHEBI:57397

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r0722
is version of: http://identifiers.org/ec-code/4.2.3.12
product: MODEL1310110015#
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true

metaR ACOAD10m
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reactant: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
type: Reaction
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

metaR TRPt
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110015#
name: L-tryptophan transport
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM hs deg3 l
is: CHEBI:16126
has only substance units: false
type: Species
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, degradation product 3
boundary condition: false

metaM ca2 c
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
type: Species
initial amount: NaN
name: calcium(2+)
constant: false
boundary condition: false
is: HMDB00464
is: SBO:0000247
initial concentration: 1.0

metaR AHEXASE2ly
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110015#_bb13cdd8_f383_4320_a119_0697813fb7a9
boundary condition: true
is encoded by: hsa:11001
name: SLC27A2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O14975
initial concentration: NaN
constant: false

metaR ETF
name: electron transfer flavoprotein
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_45e13636_2d5d_4eeb_9be5_3903cc12582d
is: O15496
is encoded by: hsa:8399
has only substance units: false
boundary condition: true
name: PLA2G10
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM coa g
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: coenzyme A(4-)
is: HMDB01423
constant: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287

metaR r1713
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM CE1926 e
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: HMDB00127
is: CHEBI:15748
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman

metaM s2l2fn2m2masn l
constant: false
type: Species
is: SBO:0000247
is: HMDB00174
name: PA6
boundary condition: false
is: CHEBI:18287
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C90H145N6O65X CHARGE: -2
initial amount: NaN

metaR DOLPMT4 Ler
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110015#

metaR r1565
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110015#

metaR SEBCOAPET
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM 4h2oglt m
initial concentration: 1.0
is: SBO:0000247
is: HMDB02070
is: CHEBI:17742
has only substance units: false
initial amount: NaN
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
type: Species
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
constant: false

metaR S2L2FN2M2MASNt
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: s2l2fn2m2masn transport, Golgi to extracellular
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_7185c19e_8bb4_4ea3_9278_5997b3de324e
name: _AI620219_1_m
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI620219
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR TTDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110015#
name: tetradecanoate (transport)
reactant: MODEL1310110015#
reversible: true

metaR CYTK5n
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
name: cytidylate kinase (CMP),nuclear

metaR LDH L
product: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110015#
fast: false
reversible: true
name: L-lactate dehydrogenase
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is: SBO:0000176

metaR ADKd
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110015#
type: Reaction
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaR VITD3t2
name: Vitamin D3 uptake
reversible: false
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is: SBO:0000185
product: MODEL1310110015#

metaM cys L e
is: CHEBI:17561
is: HMDB00574
type: Species
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

metaR r0724
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176

metaR NACHEX17ly
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110015#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176

metaR r1564
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_6bae7d4c_96f2_43ce_bbf5_0e05d6f36f3d
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: P20132
is encoded by: hsa:10993
initial amount: NaN
name: SDS
type: Species

metaR r0651
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110015#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110015#

metaM 5pmev x
type: Species
is: HMDB01343
name: (R)-5-phosphonatomevalonate(3-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58146
is: SBO:0000247
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
has only substance units: false
boundary condition: false

metaR GLYCTO1p
reactant: MODEL1310110015#
reversible: false
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is version of: http://identifiers.org/ec-code/1.1.3.15
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000269

metaM ca2 e
name: calcium(2+)
initial concentration: 1.0
is: CHEBI:29108
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b3c4488e_d1e3_4314_9447_3ac9b75cf255
is encoded by: hsa:3631
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: INPP4A
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_20b32386_430c_4bad_8734_3bd5dce0f1e3
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29922
name: NME7
type: Species
initial amount: NaN
is: Q9Y5B8
has only substance units: false
constant: false
initial concentration: NaN

metaR r0937
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
product: MODEL1310110015#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_d20463a2_1977_4871_a686_2d73edd2b322
initial concentration: NaN
name: GGT1
has only substance units: false
constant: false
boundary condition: true
is: P19440
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2678

metaR r0723
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110015#_25da50c0_c7b0_4e44_9afa_08f6726d6680
is: Q14117
is: SBO:0000252
type: Species
name: DPYS
initial concentration: NaN
constant: false
is encoded by: hsa:1807
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r1563
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5eb7dada_e7c8_4698_842e_6ff092faa731
is: SBO:0000252
has only substance units: false
name: PRDX3
is encoded by: hsa:10935
initial concentration: NaN
is: E9PH29
constant: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_e1fd1050_547d_4c33_b5aa_45a3fa3704b2
is encoded by: hsa:285973
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ATG9B
has only substance units: false
is: Q674R7
type: Species
constant: false

metaR r0650
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000

metaM ksi deg1 e
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17268
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110015#_221717cb_6315_46e4_b040_5240e9dd5423
is: Q10472
initial amount: NaN
is encoded by: hsa:2589
name: GALNT1
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaM tchola x
is: HMDB00036
is: CHEBI:36257
name: taurocholate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_1a1859a3_6060_481b_97c7_3bd625c3c3a1
is encoded by: hsa:3176
name: HNMT
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P50135
constant: false
initial amount: NaN

metaR r0726
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110015#
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaM urate c
is: CHEBI:17775
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00289
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
is: C00366

metaM cys L c
initial amount: NaN
constant: false
is: CHEBI:17561
name: L-cysteine
is: HMDB00574
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
has only substance units: false
is: SBO:0000247

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR GLUNm
reversible: false
name: glutaminase (mitochondrial)
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.1.2
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR r0321
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
fast: false
reactant: MODEL1310110015#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.5.2

http://identifiers.org/biomodels.db/MODEL1310110015#_05cf86f3_7e72_4ad6_98a4_85d7757cdd46
has only substance units: false
constant: false
initial concentration: NaN
name: NME2
is: SBO:0000252
boundary condition: true
is: P22392
initial amount: NaN
type: Species
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110015#_1f78467f_d220_4ec8_998b_3e655a444f35
name: UROD
is: P06132
is encoded by: hsa:7389
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR OCD11CRNCACT
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR DIGALSIDEtl
name: digalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110015#

metaR r1569
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_3c9e4cc2_d980_491f_a21c_62889752a184
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GALNT2
initial concentration: NaN
is: Q10471
initial amount: NaN
is encoded by: hsa:2590

metaR PCm
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM HC01444 e
boundary condition: false
name: Galactosylglycerol
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_aea7efe3_48db_463d_aa4f_43383a2039d2
initial concentration: NaN
is encoded by: hsa:3423
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: IDS
is: SBO:0000252
is: P22304
boundary condition: true

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR FUM
fast: false
reactant: MODEL1310110015#
name: fumarase
is: SBO:0000176
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
reversible: true

metaM retfa c
is: CHEBI:50211
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: fatty acid retinol
is: HMDB00305
constant: false

metaM pe hs r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
name: phosphatidylethanolamine
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_db726a6f_0fe0_4bc1_823a_e2996ba50e24
initial amount: NaN
has only substance units: false
name: SLC26A1
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:10861
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_60a080b3_c56c_4559_a037_73c8247aa059
name: KDSR
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2531
boundary condition: true
is: Q06136
is: SBO:0000252
has only substance units: false
constant: false

metaM etha c
name: etha[c]
is: SBO:0000247
is: HMDB00149
initial amount: NaN
is: CHEBI:57603
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
has only substance units: false
type: Species

metaM pheme m
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Protoheme
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
constant: false
initial amount: NaN
is: HMDB03178
boundary condition: false
is: CHEBI:17627

metaM acnam n
has only substance units: false
initial amount: NaN
name: N-acetylneuraminate
is: SBO:0000247
is: HMDB00230
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
constant: false
boundary condition: false
is: CHEBI:35418
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_9422313d_27c8_4a8f_b00f_ba4220f3b3ed
is: SBO:0000252
is: Q5JPA4
initial concentration: NaN
name: SLCO1C1
constant: false
type: Species
has only substance units: false
is encoded by: hsa:53919
boundary condition: true
initial amount: NaN

metaR r0728
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110015#

metaR r0502
is: SBO:0000176
modifier: MODEL1310110015#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.113
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false

metaM urate e
type: Species
is: C00366
has only substance units: false
initial concentration: 1.0
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
constant: false
is: HMDB00289
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Urate

metaM prostge1 e
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01442
is: CHEBI:57397

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_1e9b0667_9f8e_492c_ba4b_25b94cf9978a
constant: false
initial amount: NaN
name: ABCB4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5244
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8bf55c67_1ed2_47cc_ab4e_9c30ad8572a2
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10317
constant: false
name: B3GALT5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8b539ddf_893d_441d_b6c4_1a96456a58a4
boundary condition: true
is encoded by: hsa:5286
has only substance units: false
is: SBO:0000252
is: O00443
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: PIK3C2A

metaR ST8SIA11
reversible: false
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
modifier: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

metaM man1p c
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB06330
name: D-Mannose 1-phosphate
initial concentration: 1.0
is: CHEBI:35374
has only substance units: false

metaM s2l2fn2m2masn g
is: HMDB00868
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
name: PA6
is: CHEBI:57737
initial concentration: 1.0
has only substance units: false

metaR r0074
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: true
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_93c2fbac_94c6_4cc3_9753_ec867ffd578d
is: A8K3J4
initial concentration: NaN
has only substance units: false
boundary condition: true
name: CA14
is encoded by: hsa:23632
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM retinol 9 cis c
is: CHEBI:17336
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: 9-cis-retinol
is: HMDB06217
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_131a41d9_5ac8_485a_8bff_a17474bc059d
name: HLCS
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:3141
is: P50747
constant: false
initial concentration: NaN

metaR r1568
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM mi4p D c
boundary condition: false
initial concentration: 1.0
is: CHEBI:58469
constant: false
has only substance units: false
type: Species
is: HMDB01313
initial amount: NaN
name: 1D-myo-inositol 4-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
is: SBO:0000247

metaM HC01115 c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
type: Species
name: NeuNGc
has only substance units: false
is: CHEBI:29025

metaM dc2coa m
name: trans-Dec-2-enoyl-CoA
type: Species
initial concentration: 1.0
is: CHEBI:61406
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275

metaR ST8SIA12
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.8
is: SBO:0000176
reactant: MODEL1310110015#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110015#
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110015#

metaM 4mptnl m
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
boundary condition: false
is: HMDB01318
has only substance units: false
is: CHEBI:17998
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR CMPACNAtg
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reversible: true
modifier: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
name: CMP-Sia Golgi transport via CMP antiport
type: Reaction
kinetic law: MODEL1310110015#

metaR r1567
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110015#

metaR CHLPCTD
type: Reaction
name: choline phosphate cytididyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.15

metaM coa m
initial concentration: 1.0
boundary condition: false
name: Coenzyme A
type: Species
is: C00010
is: SBO:0000247
is: CHEBI:57287
is: HMDB01423
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

http://identifiers.org/biomodels.db/MODEL1310110015#_98516e0e_01b5_42b6_8b13_960785a97e4b
is encoded by: hsa:220
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ALDH1A3
has only substance units: false
is: P47895
boundary condition: true

metaR r1018
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
name: Transport reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaM acnam c
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
is: HMDB00230
name: N-acetylneuraminate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_bf430183_1e93_414c_9c1e_f8c664afc757
name: CA13
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:377677
boundary condition: true
is: Q8N1Q1

metaR CRNCARtp
product: MODEL1310110015#
name: carnitine-acetylcarnitine carrier, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110015#
reversible: false
fast: false
is: SBO:0000185

metaR GLYAMDTRc
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.4.1
name: glycine amidinotransferase (c)
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_3b04bd6b_f698_4c7f_9fca_b4f0a562d73c
boundary condition: true
type: Species
is encoded by: hsa:3158
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: HMGCS2
is: P54868
has only substance units: false

metaM h c
is: SBO:0000247
is: C00080
has only substance units: false
initial concentration: 1.0
name: proton
is: CHEBI:24636
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
initial amount: NaN

metaR DTDPtn
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: dTDP nuclear transport
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110015#
is described by: ECO:0000000

metaM acnacngalgbside hs e
name: disialyl galactosylgloboside
initial concentration: 1.0
is: C00036
is: SBO:0000247
constant: false
type: Species
is: CHEBI:3338
has only substance units: false
is: HMDB00223
boundary condition: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN

metaM ksi deg1 l
is: HMDB00174
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: SBO:0000247
is: CHEBI:18287
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 1
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM dudp c
initial concentration: 1.0
is: C01346
name: dUDP
is: CHEBI:60471
is: HMDB01000
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR DIGALSIDEtg
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: digalside hs intracellular transport
reversible: true
type: Reaction
is described by: ECO:0000000

metaR ASPTA
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110015#
fast: false
name: aspartate transaminase
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#

metaM s2l2fn2m2masn e
type: Species
is: HMDB00244
notes: FORMULA: C90H145N6O65X CHARGE: -2
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00255
is: CHEBI:3554
name: PA6
is: SBO:0000247
constant: false
initial amount: NaN

metaR r1570
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM dcdp c
initial concentration: 1.0
type: Species
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: dCDP
is: C00705
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_44ab1bdf_5a32_400c_90a9_9f179fa27714
type: Species
is: SBO:0000297
name: NME1:NME2
boundary condition: true
is encoded by: hsa:4830
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r1019
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0d711e24_58d3_4a3d_bc31_5133fe8e731d
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:56474
is: SBO:0000252
type: Species
name: CTPS2
is: Q9NRF8
initial amount: NaN

metaR TDCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110015#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: bile acid intracellular transport
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true

metaR r0504
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110015#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_fc78ffd3_f2f5_4219_92dc_1ff7b37d08ee
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q02318
is encoded by: hsa:1593
name: CYP27A1
constant: false

metaM ksii core2 deg3 l
is: HMDB00143
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
constant: false
name: keratan sulfate II (core 2-linked), degradation product 3
initial amount: NaN
notes: FORMULA: C58H94N5O46S2X CHARGE: -2

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM ksii core4 pre6 g
initial amount: NaN
has only substance units: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM o2 m
initial amount: NaN
has only substance units: false
type: Species
name: O2
is: SBO:0000247
is: HMDB01377
boundary condition: false
is: CHEBI:15379
is: C00007
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0

metaR FAOXTC142TC122m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR r2009
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000

metaM acnacngalgbside hs g
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
name: disialyl galactosylgloboside
constant: false
is: CHEBI:3338
type: Species
is: HMDB00223
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00036

metaM r1p c
initial amount: NaN
is: CHEBI:57720
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: C00442
name: alpha-D-Ribose 1-phosphate
is: HMDB01489

http://identifiers.org/biomodels.db/MODEL1310110015#_4bfbf7d1_2513_40ab_a098_8694b8344aa4
is: SBO:0000252
is: P31937
initial concentration: NaN
is encoded by: hsa:11112
type: Species
constant: false
boundary condition: true
has only substance units: false
name: HIBADH
initial amount: NaN

metaM tststerone r
initial amount: NaN
name: testosterone
boundary condition: false
is: HMDB00234
is: CHEBI:17347
constant: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR CSBPASEly
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaR G14T8g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR FALDH
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
product: MODEL1310110015#
name: formaldehyde dehydrogenase
fast: false
reversible: true

metaM h e
initial concentration: 1.0
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
has only substance units: false
initial amount: NaN
is: C00080
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110015#_e5469a20_af45_4deb_b7fb_203af98a4091
is encoded by: hsa:AI972237
boundary condition: true
is: SBO:0000252
name: _AI972237_1_c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM o2 n
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
name: dioxygen
initial amount: NaN
type: Species
is: CHEBI:15379
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol-5-phosphate 3-kinase
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR ASAH1
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.23
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: N-acylsphingosine amidohydrolase
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is: SBO:0000176

metaR PAPStg
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110015#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_a5ddbd2e_90ff_4737_9da1_515df392ae02
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:196883
boundary condition: true
is: SBO:0000252
is: Q8NFM4
name: ADCY4

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_8dde67aa_edb5_449e_a863_2b07665b4f48
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: PLA2G6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8398
is: A8K460

http://identifiers.org/biomodels.db/MODEL1310110015#_d9936574_3986_4463_9436_9dfadec03644
constant: false
is encoded by: hsa:117247
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q8TF71
name: SLC16A10
has only substance units: false
boundary condition: true
type: Species

metaR MM6bg
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a4e3cc97_cd59_4a9e_8c8d_b3487c99c7da
constant: false
is encoded by: hsa:56848
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9NRA0
type: Species
has only substance units: false
initial concentration: NaN
name: SPHK2

http://identifiers.org/biomodels.db/MODEL1310110015#_f54b97fd_d225_40c3_8bf0_5d7d7fdf460b
initial amount: NaN
has only substance units: false
constant: false
is: P49327
is: SBO:0000252
is encoded by: hsa:2194
initial concentration: NaN
type: Species
name: FASN
boundary condition: true

metaR 5MTAte
name: Transport of 5-S-methyl-5-thioadenosine
is described by: ECO:0000134
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_42f1c369_8718_42a8_9df3_14f759f419df
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ENTPD4
is encoded by: hsa:9583
is: Q9Y227
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_7ab1783a_cd7b_46f1_ad40_ab7097575a8b
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:516
is: SBO:0000252
initial concentration: NaN
name: ATP5G1
constant: false
is: P05496
boundary condition: true

metaR r1573
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaM ksi deg33 l
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 33
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6d54190e_3a58_4710_a690_83959cb6ec13
initial concentration: NaN
has only substance units: false
is encoded by: hsa:284111
is: SBO:0000252
type: Species
constant: false
name: SLC13A5
initial amount: NaN
is: Q86YT5
boundary condition: true

metaR ECOAH1m
type: Reaction
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.18
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110015#

metaM core4 g
constant: false
initial amount: NaN
is: CHEBI:16478
is: SBO:0000247
initial concentration: 1.0
name: Core 4
has only substance units: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
type: Species
boundary condition: false

metaR TRDR
reactant: MODEL1310110015#
is: SBO:0000176
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_481d3803_10be_4207_8e03_b0a41eb85f6d
has only substance units: false
is: SBO:0000252
is: A0PJJ9
constant: false
initial amount: NaN
name: GGT7
is encoded by: hsa:2686
initial concentration: NaN
type: Species
boundary condition: true

metaM dpcoa e
boundary condition: false
is: CHEBI:57328
constant: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
has only substance units: false
type: Species
name: Dephospho-CoA
is: C00882
initial concentration: 1.0
initial amount: NaN

metaM dpcoa c
initial amount: NaN
is: HMDB01373
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57328
is: C00882
boundary condition: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
initial concentration: 1.0

metaR OCD11COACPT1
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM h g
name: proton
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:24636
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_f2a48f13_7393_4583_81bf_9a04917ff592
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACP5
initial concentration: NaN
type: Species
constant: false
is: P13686
is encoded by: hsa:54
has only substance units: false

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cd48da59_7518_4dbd_acdb_12f8cc50ea50
boundary condition: true
initial amount: NaN
is: Q5SYN6
has only substance units: false
name: SLC22A3
is encoded by: hsa:6581
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM apoC m
is: CHEBI:32551
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: Apocarboxlase (no lys residue)
initial concentration: 1.0
is: HMDB00182
constant: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247

metaM biliverd c
type: Species
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
name: biliverdin(2-)
has only substance units: false
is: HMDB01008
constant: false
boundary condition: false
is: CHEBI:57991
initial amount: NaN
initial concentration: 1.0

metaR PCt
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.6.3.44
modifier: MODEL1310110015#
product: MODEL1310110015#
name: phosphatidylcholine transporter
kinetic law: MODEL1310110015#
type: Reaction

metaR DCK1n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
name: Deoxycytidine kinase, nuclear (ATP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM gln L m
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
boundary condition: false
is: HMDB00641
constant: false
name: L-glutamine
is: CHEBI:18050
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_71990bf1_07a0_42f5_a655_676c0f1afea8
has only substance units: false
constant: false
is encoded by: hsa:8310
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: ACOX3
initial concentration: NaN
is: O15254

metaM omhdecacid r
initial concentration: 1.0
constant: false
name: w-hydroxydecanoicacid
type: Species
has only substance units: false
is: HMDB12969
notes: FORMULA: C10H19O3 CHARGE: -1
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM HC01609 e
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: UroporphyrinogenI
constant: false
type: Species
initial amount: NaN
is: CHEBI:28766

metaR PRGNLONEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
fast: false
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000000
name: pregnenolone intracellular transport

metaR r1571
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR NACHEXA21ly
kinetic law: MODEL1310110015#
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r2110
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
fast: false

metaM o2 r
boundary condition: false
name: O2
is: SBO:0000247
is: C00007
constant: false
is: HMDB01377
is: CHEBI:15379
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
initial concentration: 1.0
initial amount: NaN

metaM ksi pre24 g
name: keratan sulfate I biosynthesis, precursor 24
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
type: Species
is: CHEBI:58053
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00130
is: HMDB00175
is: SBO:0000247
has only substance units: false

metaR r2005
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
type: Reaction
fast: false
modifier: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5393e448_e08c_4c63_90e1_2eb0f731fe79
is encoded by: hsa:4056
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: LTC4S
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR S6TASE17ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR KHte
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: KHte
product: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_37a8147e_ce4d_424a_9e23_b6f9ecc582d5
is encoded by: hsa:6240
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P23921
constant: false
name: RRM1
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_8620f467_a393_4e32_a480_bb6c9ee75e23
name: _AI222095_1_m
is encoded by: hsa:AI222095
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR r0509
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: false
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_3dfbec01_9f81_4d99_a5ea_ec6c43d3206f
has only substance units: false
is encoded by: hsa:10087
initial concentration: NaN
name: COL4A3BP
is: SBO:0000252
is: Q9Y5P4
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaR NACHEX14ly
fast: false
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110015#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR DNDPt28m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
name: dCDP transport via dGDP antiport
type: Reaction
kinetic law: MODEL1310110015#

metaR FAOXC10C8x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM gbside hs g
is: CHEBI:18259
is: SBO:0000247
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: globoside

metaR DOLPMT2 Uer
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaR FAOXC183806m
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b7e474b3_1f2c_47d0_aaa7_c1a7e4ba5bad
is: Q546H9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7915
boundary condition: true
constant: false
name: ALDH5A1
is: SBO:0000252
has only substance units: false
type: Species

metaM CE0785 m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
initial amount: NaN
is: CHEBI:57795

metaM coa x
has only substance units: false
initial amount: NaN
is: HMDB01423
is: CHEBI:57287
is: SBO:0000247
type: Species
boundary condition: false
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
constant: false
name: Coenzyme A

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: acetylcholine
constant: false
is: HMDB00895
initial concentration: 1.0
is: CHEBI:15355
type: Species

metaM prostgh2 e
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
name: prostaglandin H2(1-)
is: CHEBI:57405
is: HMDB01381
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_86a7ecd8_00a3_4edf_a12e_cc7c878cd82f
constant: false
is encoded by: hsa:4726
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q6IBC4
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFS6

metaM 4mptnl c
initial amount: NaN
name: 4-methylpentanal
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17998
is: HMDB01318
initial concentration: 1.0
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
has only substance units: false

metaR RBFK
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: riboflavin kinase
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR CH25H
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110015#
reactant: MODEL1310110015#
name: cholesterol 25-hydroxylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.99.38
is: SBO:0000176
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110015#

metaR NDPK9n
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is described by: ECO:0000269
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaM tchola e
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
has only substance units: false
name: taurocholic acid
constant: false
is: HMDB00036
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_05084bbf_920a_4f45_a4d8_43fdf545825f
has only substance units: false
initial concentration: NaN
is: E7ET30
name: AK3
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:50808
boundary condition: true
type: Species

metaR r1464
fast: false
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110015#
name: Active transport
reversible: true
is described by: ECO:0000000

metaR r2326
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR S6T16g
reactant: MODEL1310110015#
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR r2112
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM Rtotal2 c
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57876
constant: false
is: HMDB01564
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_24bba819_40e7_44e0_b45b_a8f3f4741c03
has only substance units: false
is encoded by: hsa:4708
initial amount: NaN
name: NDUFB2
is: SBO:0000252
initial concentration: NaN
is: H7C5B8
constant: false
type: Species
boundary condition: true

metaM ac m
boundary condition: false
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
is: HMDB00042
constant: false
is: CHEBI:30089
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR LPCHOLt
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
name: lysophosphatidylcholine transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
reversible: true

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM dcsptn1crn c
is: HMDB06321
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
boundary condition: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_584e58bb_ba77_4593_9903_779832bc827b
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3032
initial amount: NaN
is: SBO:0000252
is: P55084
initial concentration: NaN
type: Species
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110015#_d3331b7c_4fcb_4aa7_83d2_ef12c08b9175
is encoded by: hsa:5335
name: PLCG1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: Q9UFY1

metaR r2325
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2111
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM cmpacna n
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
is: HMDB01176
constant: false
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_637086d4_a278_4608_bc4a_d2627867c171
type: Species
has only substance units: false
constant: false
has part: Q9UHI5
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000297

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_9d3eeec8_45ef_4bca_a6bb_6dc2de14bbeb
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:125965
has only substance units: false
name: COX6B2
is: Q6YFQ2
boundary condition: true
is: SBO:0000252

metaM o2 e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00007
has only substance units: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: CHEBI:15379
name: O2

metaR r2328
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_9db2a9c4_a324_4d32_b6d2_1652a1f7b39c
name: SLC26A6
is encoded by: hsa:65010
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q548A7

metaR r2114
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM thr L c
is: CHEBI:16857
is: SBO:0000247
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-threonine

metaR HS3ly
type: Reaction
name: heparan-N-sulfatase, lysosomal
reversible: false
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110015#

metaM ksi deg13 l
is: HMDB00812
type: Species
is: CHEBI:16953
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
name: keratan sulfate I, degradation product 13
has only substance units: false
initial concentration: 1.0

metaM gdpfuc c
name: GDP-L-fucose(2-)
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: CHEBI:57984
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
is: HMDB01095
has only substance units: false

metaM Rtotal2 e
initial concentration: 1.0
constant: false
is: CHEBI:3554
initial amount: NaN
is: HMDB00244
boundary condition: false
name: R total 2 position
has only substance units: false
is: SBO:0000247
is: C00255
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaM fe2 m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00023
is: HMDB00692
is: CHEBI:29033
is: SBO:0000247
name: Fe2+
boundary condition: false
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaM cs e deg6 l
initial concentration: 1.0
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB00812
constant: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
initial amount: NaN
is: CHEBI:16953
boundary condition: false
has only substance units: false

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR DADA
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Deoxyadenosine deaminase
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
fast: false

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR DOLPGT2 Uer
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.265
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: false
is: SBO:0000176

metaR DNDPt17m
product: MODEL1310110015#
reactant: MODEL1310110015#
name: dUDP transport via dCDP antiport
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaM dpcoa m
is: HMDB01373
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57328
name: 3'-dephospho-CoA(2-)
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM hxcoa m
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06522

http://identifiers.org/biomodels.db/MODEL1310110015#_d0d8254a_13a0_47ea_b59d_0eea68c357c5
initial concentration: NaN
type: Species
is encoded by: hsa:6566
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: B4DKS0
initial amount: NaN
name: SLC16A1

http://identifiers.org/biomodels.db/MODEL1310110015#_5283c8b7_ae7c_433f_ab73_6668c92900ae
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:51227
is: SBO:0000252
name: PIGP

metaR FUMm
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
name: fumarase, mitochondrial
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.2
fast: false
is described by: ECO:0000134
type: Reaction

metaR r2116
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0870
is version of: http://identifiers.org/ec-code/3.1.3.4
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.72
modifier: MODEL1310110015#
name: Facilitated diffusion
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110015#
type: Reaction

metaM thr L e
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
initial amount: NaN
is: HMDB00167
is: CHEBI:16857
has only substance units: false
type: Species
initial concentration: 1.0
name: L-threonine
boundary condition: false

metaR r2329
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_daa6edb9_c262_4989_80dd_62069ea06ad5
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:5279
name: PIGC
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM xylu L c
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: L-xylulose
is: HMDB00751
is: CHEBI:17399
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
has only substance units: false
boundary condition: false

metaM CE2056 r
initial concentration: 1.0
is: CHEBI:57460
initial amount: NaN
has only substance units: false
name: 20-dihydroxyleukotriene B4
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1/C20H32O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-19,21-24H,1,3,9-11,14-16H2,(H,25,26)/p-1/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m0/s1 EHMN_ABBREVIATION: CE2056
is: HMDB01509
constant: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3d8a596c_8c37_4b33_8ab6_e6f35912d381
boundary condition: true
initial amount: NaN
is: Q01581
is: SBO:0000252
name: HMGCS1
initial concentration: NaN
type: Species
is encoded by: hsa:3157
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d29fc9d4_1114_4b36_b17d_c199c7f8b358
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:515
name: ATP5F1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR UGLCNACtg
is: SBO:0000185
product: MODEL1310110015#
name: UDP-GlcNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
reversible: true
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_ba736066_9fce_46ec_a17d_0dbf242d6e4b
is encoded by: hsa:3939
initial concentration: NaN
name: LDHA
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P00338
has only substance units: false

metaM hexc c
is: CHEBI:31013
is: SBO:0000247
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
constant: false
has only substance units: false
name: cerotate
initial amount: NaN
boundary condition: false
is: HMDB02356
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_41ea7a65_c72c_4307_ae8c_192e9d1f8586
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8140
is: SBO:0000252
boundary condition: true
is: Q8IV97
name: SLC7A5
constant: false
type: Species
has only substance units: false

metaR GALASE8ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
name: beta-galactosidase, lysosomal

metaM gln L e
type: Species
constant: false
has only substance units: false
name: L-glutamine
boundary condition: false
initial concentration: 1.0
is: CHEBI:18050
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
is: HMDB00641

metaR r0871
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
reversible: true
reactant: MODEL1310110015#
fast: false
name: Diffusion
type: Reaction
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ada96682_f351_4541_8601_fd8c705709a3
name: PPAT
boundary condition: true
constant: false
is: Q06203
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5471
type: Species

metaR r2115
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
is described by: ECO:0000000

metaR C4OHc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaM CE4790 m
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_331e49ba_c424_4f95_adf1_d5db6cc3f0bc
is: P07203
name: GPX1
constant: false
type: Species
is encoded by: hsa:2876
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_1d481288_2e26_472b_ad5e_91f52f33ad41
initial concentration: NaN
initial amount: NaN
is: Q96BD0
is encoded by: hsa:28231
has only substance units: false
type: Species
name: SLCO4A1
boundary condition: true
constant: false
is: SBO:0000252

metaM acnacngalgbside hs c
has only substance units: false
name: disialyl galactosylgloboside
is: SBO:0000247
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
boundary condition: false
constant: false
is: CHEBI:3338
initial concentration: 1.0
initial amount: NaN
type: Species

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
name: dCDP(3-)
is: HMDB01245
type: Species
is: CHEBI:58593
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM prostgh2 c
has only substance units: false
name: prostaglandin H2(1-)
initial concentration: 1.0
is: CHEBI:57405
is: HMDB01381
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
constant: false

metaM s2l2n2m2m l
is: HMDB00573
has only substance units: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial amount: NaN
constant: false
name: de-Fuc form of PA6 (w/o peptide linkage)
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:30825

http://identifiers.org/biomodels.db/MODEL1310110015#_a9fc7675_322b_4b63_bfe5_9abade7afe2f
name: B3GNT1
is encoded by: hsa:11041
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: O43505
is: SBO:0000252
initial amount: NaN

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00036
has only substance units: false
is: CHEBI:36257
is: SBO:0000247
initial concentration: 1.0
name: taurocholic acid

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
reversible: true

metaM HC00718 c
boundary condition: false
initial concentration: 1.0
type: Species
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM mi1p D n
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
type: Species
is: CHEBI:58433

metaR AG13T14g
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176

metaM apoC c
name: Apocarboxlase (no lys residue)
boundary condition: false
type: Species
is: HMDB11111
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:33190
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0

metaR RE2625C
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000176
name: RE2625
product: MODEL1310110015#

metaM dcdp n
is: SBO:0000247
constant: false
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
initial concentration: 1.0
is: CHEBI:58593
type: Species
initial amount: NaN
has only substance units: false
name: dCDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110015#_0feb1711_2d70_46e2_b1f8_da5a7c6edaa5
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: ACSL3
has only substance units: false
is: B3KMA6
type: Species
boundary condition: true
is encoded by: hsa:2181

metaR P5CRxm
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
name: pyrroline-5-carboxylate reductase (m)
is described by: ECO:0000304
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM gln L c
name: L-glutamine
initial amount: NaN
is: HMDB00641
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
is: SBO:0000247
has only substance units: false

metaR GLUDxm
fast: false
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110015#
name: glutamate dehydrogenase (NAD) (mitochondrial)
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
type: Reaction
reversible: true

metaM tcynt m
is: SBO:0000247
constant: false
name: thiocyanate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:18022
initial concentration: 1.0
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN

metaR r2117
is: SBO:0000185
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#

metaR KYNATESYN
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_112f0ba1_f993_4805_ae05_549c9558ae4e
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATP10A
is: SBO:0000252
constant: false
is encoded by: hsa:57194
is: O60312
boundary condition: true

metaR r0845
kinetic law: MODEL1310110015#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaR 34DHOXPEGOX
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110015#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.99.24

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r1291
kinetic law: MODEL1310110015#
name: Postulated transport reaction
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
reactant: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7ca84412_ccd9_43ff_955c_8bb2cf1692fa
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57171
is: Q86YN1
name: DOLPP1
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_087a968b_ef7a_4394_bdd6_ce52c845a2ca
is: P36269
is: SBO:0000252
type: Species
is encoded by: hsa:2687
name: GGT5
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM ksi pre17 g
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
boundary condition: false
type: Species
is: CHEBI:28067
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_baea0255_1e74_4dbc_83aa_e49a70f0e21e
initial amount: NaN
name: _AI285872_1_c
is encoded by: hsa:AI285872
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR r2347
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaM tetpent3 c
is: HMDB06323
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: tetracosapentaenoic acid, n-3

metaR 34DHPHEt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
name: 3,4-Dihydroxy-L-phenylalanine transport

http://identifiers.org/biomodels.db/MODEL1310110015#_41a6a7df_fccb_407c_8a36_7d1f6986f9c1
initial amount: NaN
name: LIPA
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: P38571
is encoded by: hsa:3988
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b361d7a6_d23b_4fc8_a2d7_f4e6dee58bb5
initial concentration: NaN
boundary condition: true
name: ENPP1
constant: false
has only substance units: false
initial amount: NaN
is: P22413
is encoded by: hsa:5167
is: SBO:0000252
type: Species

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial concentration: 1.0
constant: false
name: (S)-Hydroxydecanoyl-CoA
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28325
initial amount: NaN

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR DRPA
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000000
name: deoxyribose-phosphate aldolase
fast: false

metaM fpram c
is: HMDB06211
is: C04640
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
has only substance units: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
boundary condition: false
initial concentration: 1.0
is: CHEBI:58478

metaM clpnd c
initial concentration: 1.0
is: CHEBI:53488
constant: false
name: clupanodonic acid
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06528
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247

metaM cholate e
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
has only substance units: false
type: Species
constant: false
name: Cholate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00619

metaR HIBDm
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
is described by: ECO:0000269
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
type: Reaction
modifier: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_eb07b345_6bff_4b12_bdd7_90aa53c82580
initial amount: NaN
is: SBO:0000252
is: O95479
boundary condition: true
initial concentration: NaN
name: H6PD
has only substance units: false
is encoded by: hsa:9563
type: Species
constant: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_800ff198_1724_4ecb_932e_ec3d7feba9a8
is encoded by: hsa:5293
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:8503
has part: Q92569
type: Species
name: PIK3CD:PIK3R3
initial concentration: NaN
has only substance units: false
constant: false
has part: A7E2E0

http://identifiers.org/biomodels.db/MODEL1310110015#_f1591a7a_bc34_441c_89c6_350cdb8f7f8a
has only substance units: false
initial concentration: NaN
name: AICDA
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57379
type: Species
is: Q546Y9
constant: false

metaR r0968
name: Postulated transport reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_cc1c717d_f879_40d2_a5b9_fd971799a79f
has only substance units: false
initial concentration: NaN
type: Species
name: ACO2
is: Q99798
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50
constant: false

metaR S6T5g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000000

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_226b046b_9c7e_4d6c_b5f8_30b1338c32ce
is: Q4W5N8
has only substance units: false
is: SBO:0000252
name: AADAT
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51166
boundary condition: true
type: Species

metaM atp m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
is: HMDB00538
is: C00002

metaM ksii core2 pre6 g
has only substance units: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067

metaR r1421
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
name: Free diffusion
product: MODEL1310110015#
type: Reaction

metaM gthrd e
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
boundary condition: false
type: Species
constant: false
is: CHEBI:57925
has only substance units: false
is: SBO:0000247
name: glutathionate(1-)
initial amount: NaN

metaM tetpent3 e
is: HMDB06323
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_92973f70_c606_40dc_8fa3_decd9daaabb0
name: ATP5G3
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P48201
has only substance units: false
is encoded by: hsa:518

metaR SPODMn
type: Reaction
fast: false
modifier: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
name: superoxide dismutase, nuclear

metaR LTA4H
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
name: Leukotriene A-4 hydrolase
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2cef38a9_ec60_4133_b032_699f657d1493
has only substance units: false
is encoded by: hsa:3034
is: B4E0V8
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: HAL
is: SBO:0000252
boundary condition: true

metaM atp n
is: CHEBI:57299
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
type: Species
boundary condition: false
constant: false
name: ATP(3-)
is: HMDB00538
initial concentration: 1.0

metaR r2346
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110015#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
fast: false
kinetic law: MODEL1310110015#

metaR r0842
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110015#
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
modifier: MODEL1310110015#

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR PIter
modifier: MODEL1310110015#
is described by: ECO:0000212
is: SBO:0000185
reactant: MODEL1310110015#
reversible: true
fast: false
name: phosphate transport, endoplasmic reticulum
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_61357cd8_7708_4f75_ab33_93b7ff0d2e2d
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c
initial amount: NaN
initial concentration: NaN

metaM hepcoa m
type: Species
is: HMDB12969
is: SBO:0000247
name: heptanoylcoa
initial concentration: 1.0
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_bdd4f362_cc66_4345_8954_7d9d8b9e1688
initial concentration: NaN
is: SBO:0000252
name: PDHX
is encoded by: hsa:8050
constant: false
initial amount: NaN
is: O00330
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_afe629c2_2e1f_4ae5_9d18_753886bf2803
name: UGCG
initial concentration: NaN
is: Q16739
initial amount: NaN
type: Species
is encoded by: hsa:7357
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR RE3568C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
type: Reaction
reversible: true
name: RE3568
fast: false
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_5e235ec2_51b1_42c6_8c51_2ee08207cef4
has only substance units: false
name: SULT1A1
boundary condition: true
is encoded by: hsa:6817
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaM n2m2mn l
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: HMDB00243
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: CHEBI:15361
has only substance units: false
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: C00022
initial amount: NaN

metaR r0339
modifier: MODEL1310110015#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.2.2
is version of: http://identifiers.org/ec-code/3.1.2.22
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction

metaM gthrd c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00125
type: Species
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
name: Reduced glutathione
is: C00051

http://identifiers.org/biomodels.db/MODEL1310110015#_9925dc72_b22c_4114_8672_a09d722f66c4
initial amount: NaN
name: QPRT
is encoded by: hsa:23475
boundary condition: true
type: Species
constant: false
has only substance units: false
is: Q15274
is: SBO:0000252
initial concentration: NaN

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
boundary condition: false
is: C00022
name: pyruvate
initial concentration: 1.0
is: CHEBI:15361
constant: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
is: SBO:0000247

metaM leuktrD4 r
is: CHEBI:28666
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Leukotriene D4
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
is: HMDB03080
type: Species

metaR r2433
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_4b21788a_d3bb_49da_9b95_9ba4e1218e62
is encoded by: hsa:1431
name: CS
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_69904b73_cfbf_44be_be0c_dad06b370071
initial concentration: NaN
name: SLC17A2
type: Species
is: O00624
is encoded by: hsa:10246
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR LCADi D
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110015#
name: lactaldehyde dehydrogenase
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reversible: false

metaR AGTim
is: SBO:0000176
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
fast: false

metaM ach c
initial amount: NaN
is: HMDB00895
has only substance units: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR MMSAD3m
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.27
reversible: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
product: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_77ddb51c_7b22_4cdf_ba2b_b4537a1f0991
boundary condition: true
is encoded by: hsa:11000
has only substance units: false
name: SLC27A3
is: SBO:0000252
initial amount: NaN
type: Species
is: Q5K4L6
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_533b52ad_9cdb_41b0_87d2_6a8362a9c238
name: SKIV2L2
is: Q3MHC9
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:23517
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM HC01223 m
constant: false
is: CHEBI:57340
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
type: Species
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

metaR r2344
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110015#_6c8d73bf_6a95_43e8_bf3a_65192d87d116
is: SBO:0000252
is: Q8NFL0
type: Species
name: B3GNT7
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:93010
constant: false

metaR r2119
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_6741625c_181e_4928_8c09_5ff2b33ef9be
constant: false
name: GSTZ1
type: Species
initial amount: NaN
is: SBO:0000252
is: A6NED0
boundary condition: true
has only substance units: false
is encoded by: hsa:2954
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_9f8fc32b_9b6a_4bcc_b46f_1ca7b0933804
has only substance units: false
initial concentration: NaN
is encoded by: hsa:284098
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q7Z7B1
name: PIGW
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_1f080807_06d2_4c06_8b22_776cfaa4bd71
type: Species
is: P11926
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4953
name: ODC1
has only substance units: false

metaR r2341
reactant: MODEL1310110015#
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR ADNt
is described by: ECO:0000269
reversible: true
name: adenosine facilated transport in cytosol
modifier: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110015#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_2225a8be_8ded_4324_a464_be00ac41ae62
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: P30837
name: ALDH1B1
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:219

metaM thcrm hs g
boundary condition: false
name: trihexosyl ceramide
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: CHEBI:24636
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_7efebd2e_da5d_4173_9155_6c5233ec0e47
boundary condition: true
has only substance units: false
is encoded by: hsa:7296
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: TXNRD1
is: Q16881
initial concentration: NaN

metaR NRVNCCOAtx
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction

metaR 4NPHSFte
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_505fffdb_41ed_4d0d_ae02_dcca010fd021
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q15735
initial concentration: NaN
type: Species
name: INPP5J
constant: false
is encoded by: hsa:27124
is: SBO:0000252

metaM cholate c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00619
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:29747
name: Cholate

metaR APOCFm
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
product: MODEL1310110015#
name: Apocarboxylase formation, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_5b68aae2_aa49_424a_abd8_a368300b6cb1
has only substance units: false
name: CS
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:1431
is: SBO:0000252
is: O75390
initial concentration: NaN
type: Species

metaM acgam1p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
constant: false
type: Species
has only substance units: false
name: N-Acetyl-D-glucosamine 1-phosphate
initial amount: NaN
is: HMDB01367
initial concentration: 1.0
is: CHEBI:7125
boundary condition: false
is: SBO:0000247

metaR r0963
product: MODEL1310110015#
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000

metaM ocdca e
boundary condition: false
type: Species
is: CHEBI:25629
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
name: octadecanoate (n-C18:0)
is: SBO:0000247
constant: false
is: C01530
initial amount: NaN

metaR r1147
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM ach e
constant: false
is: CHEBI:15355
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00895
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_5632a9bc_ebb9_4fa9_bc2f_34cfb892aba8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U52111
type: Species
is: SBO:0000252
has only substance units: false
name: _U52111_1_c
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c411d823_e834_4c08_adcb_d2b5dd5e1b74
is: SBO:0000252
is: Q9GZV3
initial amount: NaN
is encoded by: hsa:60482
name: SLC5A7
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaM lys L x
initial concentration: 1.0
name: L-lysinium(1+)
is: HMDB00182
is: CHEBI:32551
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

http://identifiers.org/biomodels.db/MODEL1310110015#_48b940f5_3a47_45ed_97c6_a7b45ba7cb72
has only substance units: false
type: Species
is: Q08ET0
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ATP5F1
is encoded by: hsa:515
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_84d10a3e_859e_47d8_b79a_6a7563320015
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AI378339
is: SBO:0000252
name: _AI378339_1_m
initial amount: NaN
initial concentration: NaN

metaR SPODMx
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, peroxisome
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110015#
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_a26f50ce_4918_4e81_9f7e_8a3a85ad81d8
type: Species
is encoded by: hsa:3073
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: HEXA
is: P06865

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
kinetic law: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d33a8668_7b1c_41cf_9e7e_5c7eccacbb72
name: NDUFV2
boundary condition: true
type: Species
is: SBO:0000252
is: P19404
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4729
initial amount: NaN
constant: false

metaR CITtam
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110015#
name: citrate transport, mitochondrial
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_6cb409c8_f6f8_42c8_9730_30256c42470e
has only substance units: false
constant: false
boundary condition: true
name: _BC005314_1_x
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:BC005314

metaR RE2999M
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110015#
name: RE2999

http://identifiers.org/biomodels.db/MODEL1310110015#_6fa50451_8820_490f_9fda_167093159897
initial amount: NaN
type: Species
is encoded by: hsa:4712
name: NDUFB6
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O95139

http://identifiers.org/biomodels.db/MODEL1310110015#_f484b54d_84d1_4769_ae11_96e09473b81c
is: Q6IA69
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55191
name: NADSYN1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_71f85515_39f3_4c5e_bdba_3e4e629ef701
initial concentration: NaN
name: PGD
initial amount: NaN
is: A8K2Y9
type: Species
is: SBO:0000252
is encoded by: hsa:5226
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_66ea589c_9861_49d1_b0e8_e2a34fdec033
initial amount: NaN
name: PDE4D
has only substance units: false
is: SBO:0000252
is: Q08499
constant: false
boundary condition: true
is encoded by: hsa:5144
initial concentration: NaN
type: Species

metaR SCP22x
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
name: Sterol carrier protein 2
type: Reaction
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM galside hs c
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
constant: false
is: CHEBI:12947
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_3c55eba0_47b9_442c_97db_59adcda2757e
constant: false
boundary condition: true
name: SDHA
initial concentration: NaN
is encoded by: hsa:6389
initial amount: NaN
is: P31040
has only substance units: false
type: Species
is: SBO:0000252

metaR r1579
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110015#_91f0f02c_59ea_431c_a93b_11b7e5d51f04
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O43708
is encoded by: hsa:2954
type: Species
constant: false
name: GSTZ1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_09dd16d9_7f21_4b6e_97b1_9a45f6d1793b
is encoded by: hsa:26330
constant: false
is: O14556
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: GAPDHS

http://identifiers.org/biomodels.db/MODEL1310110015#_b04c7f97_f2bc_48e5_a1c2_68d274bdd363
boundary condition: true
type: Species
is: P36959
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2766
name: GMPR
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0739
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110015#
is: SBO:0000176

metaR G12MT1 U
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000

metaM gthrd m
is: SBO:0000247
name: glutathionate(1-)
type: Species
constant: false
has only substance units: false
is: CHEBI:57925
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: HMDB00125
boundary condition: false
initial concentration: 1.0

metaR r0512
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: true
is: SBO:0000176

metaM pyr x
is: C00022
initial concentration: 1.0
constant: false
name: pyruvate
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
is: CHEBI:15361
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false

metaR FAOXC204
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110015#

metaM 7dhchsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol
constant: false
is: CHEBI:17759
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00032

metaR S23T3g
is version of: http://identifiers.org/ec-code/2.4.99.6
is: SBO:0000176
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
kinetic law: MODEL1310110015#
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
modifier: MODEL1310110015#

metaM occoa c
has only substance units: false
is: HMDB01070
is: C01944
is: CHEBI:57386
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
is: SBO:0000247
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_342c7988_2a8a_464b_aaaf_4ef8e35e346d
name: HK1
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3098
is: P19367
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_0dedb35c_09c3_4b70_9ac3_05c813c284ec
is: SBO:0000252
initial amount: NaN
name: DLAT
type: Species
initial concentration: NaN
is: Q86YI5
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1737

metaR GALASE13ly
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110015#
reversible: false
is: SBO:0000176
type: Reaction

metaR r1429
fast: false
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110015#

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM hs deg25 l
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:16126
has only substance units: false
boundary condition: false
notes: FORMULA: C23H37O21 CHARGE: -1
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_a7622058_92ea_41ac_8542_a59671e78abe
is: P42765
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10449
name: ACAA2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM ksi deg24 l
name: keratan sulfate I, degradation product 24
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110015#_4c907874_c4a4_4317_80a6_f35eab512840
is: SBO:0000252
type: Species
boundary condition: true
is: Q9BWD1
constant: false
has only substance units: false
name: ACAT2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:39

metaR 2HCO3 NAt
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reversible: true
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaR RE3001M
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.1.34
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
name: RE3001
is: SBO:0000176
product: MODEL1310110015#

metaR SRTNtu
name: Serotonin uniport
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false

metaR RIBt
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribose transport via diffusion
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_dd39c1d3_d28d_4bb7_9d36_890e2c491159
name: TPO
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:7173
initial amount: NaN
constant: false

metaR UGALNACtg
is described by: ECO:0000269
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaR SBTR
type: Reaction
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: D-sorbitol reductase
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR r1428
reversible: true
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
reactant: MODEL1310110015#
fast: false

metaR CITRtm
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110015#
name: citrulline mitochondrial transport via proton antiport

metaR r1576
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR PIPLCn
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
fast: false
name: phosphatidylinositol phospholipase C, nucleus
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#

metaM xolest2 hs e
initial amount: NaN
initial concentration: 1.0
name: cholesterol ester
boundary condition: false
type: Species
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:17002
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3fa5b69b_8a2c_4c9f_9f32_b1945005052a
constant: false
initial concentration: NaN
name: _AV717590_1_m
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AV717590
has only substance units: false

metaM guln c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-gulonate
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
is: HMDB03290
has only substance units: false
is: CHEBI:13115

http://identifiers.org/biomodels.db/MODEL1310110015#_bd537cd6_9124_4088_8dd3_fd58c8f87fd3
name: GMPR2
is encoded by: hsa:51292
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM leuktrF4 c
constant: false
is: HMDB06465
name: leukotriene F4
is: CHEBI:27491
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_cccd714c_3a89_46e8_9469_7963bc6decdd
initial amount: NaN
is encoded by: hsa:160851
boundary condition: true
initial concentration: NaN
is: A8K0I1
constant: false
type: Species
has only substance units: false
name: DGKH
is: SBO:0000252

metaR r1575
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction

metaM imp e
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
constant: false
is: HMDB00175
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
name: IMP(2-)
boundary condition: false
is: SBO:0000247

metaR PGLc
product: MODEL1310110015#
reactant: MODEL1310110015#
name: 6-phosphogluconolactonase
is described by: ECO:0000134
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (25796.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 3
type: Reaction
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.31
reversible: false

metaR r0735
is: SBO:0000176
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR FDH
is version of: http://identifiers.org/ec-code/1.5.1.6
modifier: MODEL1310110015#
type: Reaction
is described by: ECO:0000304
fast: false
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
name: formate dehydrogenase
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaM ksi deg10 l
constant: false
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
type: Species
is: HMDB00812
is: CHEBI:16953
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 10
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM 4mzym int1 r
type: Species
has only substance units: false
boundary condition: false
is: HMDB06927
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
name: 4-Methylzymosterol intermediate 1

http://identifiers.org/biomodels.db/MODEL1310110015#_a5cd0754_c4a2_4285_a4ff_a365f1bdc3f5
name: GLA
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2717
is: SBO:0000252
has only substance units: false
constant: false
is: Q53Y83
initial amount: NaN
type: Species

metaR r0060
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
fast: false
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_8858f0a9_8347_42cb_8135_be25cca09128
boundary condition: true
constant: false
is encoded by: hsa:AU149534
name: _AU149534_1_e
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_b59abbfd_dfdd_4b52_bc4c_bb9d19aa5a2e
boundary condition: true
has part: P23921
type: Species
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:6240
initial amount: NaN
is encoded by: hsa:6241
has only substance units: false
has part: P31350
name: RRM1:RRM2

metaM atp r
is: C00002
name: ATP(4-)
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00538
boundary condition: false
is: CHEBI:57299
initial concentration: 1.0

metaR r1578
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e3151465_1741_4ca1_8503_0bb5cf64e0e0
type: Species
is: SBO:0000252
is encoded by: hsa:8813
name: DPM1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: O60762
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_a2151071_effa_4411_8f98_a452d1f3ecdb
constant: false
name: SYNJ1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8867
boundary condition: true
is: C9JFZ1

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110015#

metaR B MANNASEly
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.25
fast: false
name: beta-mannosidase, lysosomal
is described by: ECO:0000000
reversible: false
type: Reaction

metaM pdx5p c
initial concentration: 1.0
is: HMDB01319
initial amount: NaN
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
boundary condition: false
constant: false
is: C00627
is: CHEBI:58589
type: Species
is: SBO:0000247
has only substance units: false
name: Pyridoxine 5'-phosphate

metaM clpndcoa c
type: Species
name: clupanodonyl CoA
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205476
is: HMDB06267
has only substance units: false
is: SBO:0000247
is: C16166
initial amount: NaN
constant: false

metaR UAG4E
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
is: SBO:0000176

metaM leuktrF4 e
initial amount: NaN
boundary condition: false
name: leukotriene F4
constant: false
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
is: HMDB06465
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 5htrp c
type: Species
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
constant: false
initial concentration: 1.0
is: HMDB00472
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17780
name: 5-hydroxy-L-tryptophan

http://identifiers.org/biomodels.db/MODEL1310110015#_1af7bce5_ca4d_4c1c_a400_7aae3fd89918
has only substance units: false
name: ADH5
boundary condition: true
initial amount: NaN
is: Q6IRT1
type: Species
is encoded by: hsa:128
constant: false
initial concentration: NaN
is: SBO:0000252

metaR FAOXC2051843m
product: MODEL1310110015#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR r0733
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_488b15d7_3caf_4ced_af9f_c18d34cdb158
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: P22830
initial amount: NaN
is encoded by: hsa:2235
name: FECH

http://identifiers.org/biomodels.db/MODEL1310110015#_cc2c83bc_474f_4c68_b73f_a9752aed7da0
initial amount: NaN
is: B7Z8Z3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4051
constant: false
type: Species
name: CYP4F3
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_039b433a_027e_4e04_86e9_1a3cb961a9ba
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: ALDOA
initial concentration: NaN
boundary condition: true
is: P04075
is encoded by: hsa:226

metaM galside hs l
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
is: CHEBI:12947
boundary condition: false
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

http://identifiers.org/biomodels.db/MODEL1310110015#_eb59e588_653c_401b_b57c_42dc1bcd27bf
is: Q8TCG5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CPT1C
type: Species
is encoded by: hsa:126129
constant: false
initial amount: NaN

metaR EX i LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Iodide exchange
type: Reaction

metaM val L m
is: CHEBI:16414
boundary condition: false
is: HMDB00883
has only substance units: false
constant: false
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR FACOAL226
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
name: fatty-acid--CoA ligase

metaM k e
has only substance units: false
is: CHEBI:29103
initial amount: NaN
is: C00238
is: HMDB00586
name: potassium
boundary condition: false
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r2122
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000

metaR r0340
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaR r0731
is: SBO:0000176
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000

metaR r1583
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DNDPt8m
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
name: dADP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110015#
reversible: false
is: SBO:0000185
fast: false

metaM idp c
has only substance units: false
is: HMDB03335
initial concentration: 1.0
is: CHEBI:58280
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false

metaR DOPASFt
is: SBO:0000185
name: Dopamine 3-0-sulfate transport (diffusion)
reversible: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate

metaR r2538
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110015#

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

metaR GLNS
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_dcc188b2_7098_4e2f_80a7_5482d937a1ab
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: BCKDHB
is encoded by: hsa:594
constant: false
is: Q9BQL0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d193bd09_8b00_4045_8322_272d68fdfe46
is encoded by: hsa:482
initial concentration: NaN
initial amount: NaN
constant: false
has part: P14415
has only substance units: false
boundary condition: true
is: SBO:0000297
type: Species
name: ATP1A3:ATP1B2

metaR SERDGLYexR
type: Reaction
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
name: D-Serine/Glycine reversible exchange
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r0732
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR TSTSTERONEt
name: Testosterone transport
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110015#
reversible: true

metaR F1Atg
reversible: true
name: F1alpha transport (from golgi to lysosome)
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000

metaM 10fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_cea2610f_1bca_4863_9f63_efc6178d1688
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:8706
boundary condition: true
is: Q49AT3
constant: false
is: SBO:0000252
has only substance units: false
name: B3GALNT1

metaR r1584
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaM 4izp c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01014
boundary condition: false
constant: false
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: SBO:0000247
type: Species
name: 4-Imidazolone-5-propanoate

metaR r2537
reversible: true
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ae09dc67_e0dc_4f5e_aa80_3f3e58d3a74b
is encoded by: hsa:8034
type: Species
constant: false
is: P16260
name: SLC25A16
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_0ccb163e_d0a6_4fa7_9197_51721c37fa71
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:NOS2A
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: _NOS2A_1_c

metaR r2121
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
fast: false

metaR BTNDm
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_52707274_f15b_40b9_9cf2_8b2f301ca93b
boundary condition: true
name: PCK2
is encoded by: hsa:5106
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q16822
has only substance units: false
initial amount: NaN

metaR DESAT16 2
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
is version of: http://identifiers.org/ec-code/1.14.19.1

http://identifiers.org/biomodels.db/MODEL1310110015#_dc9130ab_047f_4de1_b4de_d2dcb653f6cf
boundary condition: true
constant: false
name: GPX3
is: P22352
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2878
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_7e7075cf_2db9_4311_8dbd_72bc8e3a5e47
type: Species
is: SBO:0000252
is: E2QRH8
boundary condition: true
initial concentration: NaN
name: PLCB4
is encoded by: hsa:5332
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9e129541_d4f5_4707_9d0d_5a8e20969330
constant: false
is: O95299
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NDUFA10
is encoded by: hsa:4705
is: SBO:0000252
boundary condition: true

metaM k c
constant: false
is: SBO:0000247
is: CHEBI:29103
initial amount: NaN
name: potassium
is: C00238
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: HMDB00586
type: Species
initial concentration: 1.0
has only substance units: false

metaM imp c
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00130
boundary condition: false
constant: false
name: IMP
type: Species
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

metaM dolmanp U c
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15809
constant: false

metaM ttetddcoa m
type: Species
name: trans5,8tetradecadienoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02288
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r2120
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction

metaM CE2417 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB11123
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: CHEBI:28387

metaM ksi deg17 l
initial concentration: 1.0
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 17
boundary condition: false
has only substance units: false
is: CHEBI:12936
constant: false

metaR HPDCACRNCPT2
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110015#
reversible: false
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r2535
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110015#

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

metaM 4aphdob c
boundary condition: false
initial concentration: 1.0
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58147
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
is: HMDB00978
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_426acf60_fcd7_4c1d_a596_6b139d542019
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: SARDH
is: A8K596
is encoded by: hsa:1757
constant: false

metaR q10h2tc
type: Reaction
reversible: true
reactant: MODEL1310110015#
name: transport of ubiquinol into cytosol
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_9d724b8c_bafe_4147_a35f_1cca61a327d5
is: SBO:0000252
initial concentration: NaN
name: FUT8
is encoded by: hsa:2530
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: B4DFS7

metaR r1586
type: Reaction
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110015#

metaR r0730
reactant: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110015#

metaR INSTt2r
fast: false
name: inositol transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaR 4ABUTtm
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
name: 4-aminobutanoate mitochondrial transport via diffusion
is: SBO:0000185
fast: false
kinetic law: MODEL1310110015#

metaR GGT6
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
name: Gamma-glutamyltransferase

http://identifiers.org/biomodels.db/MODEL1310110015#_4d3b08ba_0096_4443_91ec_84f0a235cc40
constant: false
initial concentration: NaN
is: Q53HM1
initial amount: NaN
boundary condition: true
is encoded by: hsa:54963
type: Species
has only substance units: false
is: SBO:0000252
name: UCKL1

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
is: SBO:0000247
name: Nitric oxide
is: C00533
boundary condition: false
is: CHEBI:16480
is: HMDB03378
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR 4MPTNLte
type: Reaction
is: SBO:0000185
name: 4-methylpentanal transport
product: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
kinetic law: MODEL1310110015#
fast: false

metaR BTNt2
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
name: Biotin reversible transport via proton symport
reversible: true

metaR r0517
product: MODEL1310110015#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR H2O2t
reactant: MODEL1310110015#
reversible: true
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF

metaR r2534
product: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_e835c6a4_e3f2_49df_aa9e_ee0e08e4f109
is encoded by: hsa:10558
constant: false
initial amount: NaN
initial concentration: NaN
name: SPTLC1
boundary condition: true
is: SBO:0000252
is: O15269
type: Species
has only substance units: false

metaM ksi pre21 g
is: C00130
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 21
boundary condition: false
is: HMDB00175
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: CHEBI:58053

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaR CYTK1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
fast: false
reactant: MODEL1310110015#
reversible: true
type: Reaction
name: cytidylate kinase (CMP),mitochondrial
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaR 5ADTSTSTERONESte
fast: false
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
product: MODEL1310110015#
name: sulfonated testosterone transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction

metaM hspg l
is: CHEBI:17899
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01993
name: heparan sulfate proteoglycan
has only substance units: false
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial amount: NaN

metaM citr L m
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00904
boundary condition: false
has only substance units: false
type: Species
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349

http://identifiers.org/biomodels.db/MODEL1310110015#_1f75f513_6b98_4eda_8832_b3a11134701e
is: Q16836
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: HADH
is encoded by: hsa:3033
is: SBO:0000252

metaM CE2433 m
is: SBO:0000247
constant: false
is: CHEBI:57795
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
has only substance units: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM galside hs g
is: CHEBI:12947
type: Species
name: D-galactosyl-N-acylsphingosine
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR DHORTS
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
product: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000269
name: dihydroorotase
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_f504bfbe_a7f2_4db8_bd13_62a543ea6782
boundary condition: true
is encoded by: hsa:34
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: P11310
name: ACADM
is: SBO:0000252
has only substance units: false

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR CYTK1n
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110015#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
name: cytidylate kinase (CMP),nuclear

metaM leuktrD4 c
constant: false
is: CHEBI:28666
name: Leukotriene D4
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB03080
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247

metaR C160CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
type: Reaction
fast: false
name: C160 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110015#
reversible: false
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_c76ddd53_a8df_41fe_9958_b373a88b03d6
is: Q9HAS3
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC28A3
type: Species
initial concentration: NaN
is encoded by: hsa:64078

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_176031ef_2fc2_48be_8dd3_2e31a14f7f6d
initial concentration: NaN
is encoded by: hsa:53354
constant: false
name: PANK1
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR RE0689E
fast: false
name: RE0689
reversible: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#

metaR r2532
product: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction

metaR ACACt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110015#
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
name: Acetoacetate mitochondrial transport via H+ symport
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_136bbb7d_eddb_4b86_a849_01557c75453e
type: Species
is: O43916
has only substance units: false
constant: false
is encoded by: hsa:8534
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: CHST1
is: SBO:0000252

metaR PYDAMK
fast: false
name: pyridoxamine kinase
type: Reaction
modifier: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.35
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1a8e2deb_a5bc_4c0f_b230_0050cf518641
type: Species
initial amount: NaN
is: B7Z6S9
boundary condition: true
initial concentration: NaN
name: GBA
is encoded by: hsa:2629
has only substance units: false
is: SBO:0000252
constant: false

metaM bamppald c
is: SBO:0000247
name: beta-Aminopropion aldehyde
initial amount: NaN
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
constant: false
has only substance units: false
initial concentration: 1.0
is: C05665
boundary condition: false
type: Species
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665

metaR r1581
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

metaM idp e
is: HMDB03335
is: SBO:0000247
name: IDP(3-)
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58280
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false

metaR FACOAL224
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
name: fatty-acid--CoA ligase
modifier: MODEL1310110015#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR DPCOAK
reversible: false
name: dephospho-CoA kinase
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.3
fast: false
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_84e164ee_7e95_46d5_9a1a_e8725a83a534
is: SBO:0000252
initial concentration: NaN
name: _BE966236_1_m
boundary condition: true
is encoded by: hsa:BE966236
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR Asn X Ser Thrtr
is described by: ECO:0000269
reversible: true
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM dsmsterol r
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02719
name: desmosterol
initial concentration: 1.0
is: CHEBI:17737
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_79fdcbb2_7495_432d_aa6c_58a56376af88
type: Species
has only substance units: false
is: SBO:0000252
name: _AV713053_1_m
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AV713053
initial amount: NaN

metaM pe hs m
name: phosphatidylethanolamine
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR CMPACNAtn
name: CMP-Sia nuclear export
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaM ksi deg30 l
initial concentration: 1.0
boundary condition: false
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
initial amount: NaN
name: keratan sulfate I, degradation product 30
type: Species
constant: false
has only substance units: false

metaM leuktrD4 e
is: CHEBI:28666
type: Species
name: Leukotriene D4
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB03080
is: SBO:0000247
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false

metaR GNDer
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_acacbd0e_e2e6_4ed6_a330_1d1c7ee886d0
is: SBO:0000252
has only substance units: false
name: ACAA1
is: Q96CA6
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:30

metaR SPHINGStl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
fast: false
name: sphingosine intracellular transport
kinetic law: MODEL1310110015#

metaM hs deg4 l
is: CHEBI:16126
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: heparan sulfate, degradation product 4
is: SBO:0000247
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
constant: false
initial amount: NaN

metaR SERtN1
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Serine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reversible: true

metaM val L e
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00883
is: SBO:0000247
constant: false
has only substance units: false
name: L-valine
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaM ocdca c
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00827
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
boundary condition: false
constant: false
initial amount: NaN
name: stearate

metaR RE1517M
fast: false
name: RE1517
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_78e705c2_63c0_4725_8cbb_f4b4b033cacd
initial amount: NaN
is: SBO:0000252
constant: false
name: _F23536_1_m
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:F23536
boundary condition: true

metaR RE2659R
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
type: Reaction
is described by: ECO:0000000
name: RE2659
product: MODEL1310110015#

metaR KSItly
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110015#
name: keratan sulfate I transport, extracellular to lysosome
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false

metaM 10fthf c
is: SBO:0000247
name: 10-Formyltetrahydrofolate
type: Species
constant: false
is: HMDB00972
boundary condition: false
has only substance units: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial concentration: 1.0
initial amount: NaN

metaR LNELDCCRNt
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110015#
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110015#
fast: false

metaR r2129
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_143e890b_f9a8_4e81_aaa7_c041b2e68061
constant: false
type: Species
name: ATP5A1
is encoded by: hsa:498
boundary condition: true
has only substance units: false
initial amount: NaN
is: A8K092
is: SBO:0000252
initial concentration: NaN

metaR TETTET6COAtx
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_53aeb083_b497_41ed_9746_afaf3da5df84
name: ABCB4
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5244
constant: false
is: P21439
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_79be72af_4a00_4237_a63e_19ee9f141fb0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q8IXW6
constant: false
type: Species
name: DPYSL3
boundary condition: true
is encoded by: hsa:1809

http://identifiers.org/biomodels.db/MODEL1310110015#_eb96c27f_63f4_4d38_a3ef_deca7cc31516
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _NOS2A_1_e
is: SBO:0000252
is encoded by: hsa:NOS2A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_d8f528f9_33b2_4f54_97a4_0f7e89638967
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q502Y3
is encoded by: hsa:7173
boundary condition: true
name: TPO
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_58b1ecd2_1dcd_4b90_92cf_582b89b20522
is encoded by: hsa:4706
has only substance units: false
is: O14561
name: NDUFAB1
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM pe hs c
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
constant: false
has only substance units: false
is: CHEBI:16038
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_492b3db7_0655_42f0_b70f_f4adb2b13dc7
is encoded by: hsa:3295
constant: false
is: E9PB82
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: HSD17B4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_5da01a33_0c4a_4eb6_a4a8_009fe4fbed77
type: Species
name: SLC6A10P
has only substance units: false
is encoded by: hsa:386757
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
fast: false
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110015#

metaM atp c
type: Species
constant: false
initial concentration: 1.0
name: ATP(4-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:30616
is: HMDB00538
is: C00002

metaR HSAT4ly
reversible: false
kinetic law: MODEL1310110015#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185
fast: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_248141b2_e7d6_4bee_bf2c_9762e2d64f27
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:51604
boundary condition: true
initial concentration: NaN
name: PIGT
constant: false
is: Q969N2

metaR r0627
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR NP1
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
name: nucleotide phosphatase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR r2128
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_661a20d2_1b78_4df4_94cd_12799b27e30e
is encoded by: hsa:5151
name: PDE8A
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR FAOXC201C181x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM val L c
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00883
name: L-valine
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4c6c1bf6_c9bc_4468_9225_4d51a2b7ef28
is encoded by: hsa:10678
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: B3GNT2
has only substance units: false

metaM pmtcrn c
initial concentration: 1.0
constant: false
type: Species
name: L-palmitoylcarnitine
is: CHEBI:17490
boundary condition: false
is: HMDB00222
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b1c1340f_3bbb_44c3_8cb4_ef0827fe2c86
initial amount: NaN
name: MECR
has only substance units: false
is: SBO:0000252
type: Species
is: Q9BV79
boundary condition: true
is encoded by: hsa:51102
constant: false
initial concentration: NaN

metaM guln r
name: L-gulonate
boundary condition: false
is: CHEBI:13115
constant: false
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB03290
is: SBO:0000247

metaR PIt7
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
modifier: MODEL1310110015#
fast: false
reversible: true
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

http://identifiers.org/biomodels.db/MODEL1310110015#_bec5e3e0_9db4_476f_bf51_4d19f4532eea
is: SBO:0000252
is encoded by: hsa:5296
boundary condition: true
has only substance units: false
constant: false
type: Species
name: PIK3R2
initial concentration: NaN
initial amount: NaN
is: O00459

metaM no c
is: HMDB03378
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
is: CHEBI:16480
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Nitric oxide
type: Species

metaR CYOR u10m
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110015#
fast: false
is described by: ECO:0000134

metaR r2127
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_d697c763_785e_445e_9499_e7b2c49d80ab
initial amount: NaN
is: SBO:0000252
name: OGDH
type: Species
initial concentration: NaN
boundary condition: true
is: Q02218
is encoded by: hsa:4967
constant: false
has only substance units: false

metaR FAOXC185C164m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR VALt5m
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185

metaR APOC LYS BTNP
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
name: proteolysis of apoC-Lys-btn
is described by: ECO:0000000
type: Reaction

metaR r0960
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110015#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ceb71591_a9b5_45c2_b657_784a6c1ac5f2
is encoded by: hsa:100
initial amount: NaN
is: P00813
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: ADA
boundary condition: true

metaM atp e
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: ATP(4-)
is: HMDB00538
is: CHEBI:57299
is: C00002
is: SBO:0000247

metaM xol7ah2 m
has only substance units: false
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28047
constant: false
initial amount: NaN
is: HMDB06893
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha-diol

http://identifiers.org/biomodels.db/MODEL1310110015#_059441ee_b6fa_4111_8b01_f50cc6b20aec
is encoded by: hsa:54995
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9NWU1
has only substance units: false
name: OXSM
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_f06bcb76_e803_46f2_9642_413d7638929f
is encoded by: hsa:3613
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: O14732
is: SBO:0000252
name: IMPA2

http://identifiers.org/biomodels.db/MODEL1310110015#_fcc7cc11_06ca_4a31_8568_2f9632a64d5e
has only substance units: false
name: PIGN
type: Species
is: O95427
initial concentration: NaN
is encoded by: hsa:23556
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM g1m8mpdol U r
type: Species
initial concentration: 1.0
is: CHEBI:59093
constant: false
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
initial amount: NaN
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR S6T17g
reactant: MODEL1310110015#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false

metaR r0840
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.14.13.70
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: Free diffusion
is: SBO:0000185
product: MODEL1310110015#

metaR C226CRNt
name: C226 transport into the mitochondria
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR DOPAtu
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
name: Dopamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_d4ca92ce_10f3_4384_a05a_37cb82da90eb
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6FIH7
is: SBO:0000252
name: ATP5G1
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:516

http://identifiers.org/biomodels.db/MODEL1310110015#_7aef5109_3db0_401c_84cc_e36ebef6aba1
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:158
name: ADSL
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_c10aedcd_9f9c_4067_bcf4_67faa80ab158
has only substance units: false
is: B2R6S5
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: CMPK1
is encoded by: hsa:51727
constant: false
initial amount: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR r2126
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#

metaR r1856
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
reversible: false
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false

metaR 4MPTNLtm
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
name: 4-methylpentanal transport (mitochondria)
reversible: true
type: Reaction

metaM pyr e
is: HMDB00243
type: Species
is: CHEBI:15361
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate

metaR HPDCACRNCPT1
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_b01f0220_58c0_46af_ae09_bcc8050f1c30
initial amount: NaN
constant: false
is encoded by: hsa:51102
is: SBO:0000252
is: Q9BV79
has only substance units: false
initial concentration: NaN
boundary condition: true
name: MECR
type: Species

metaM dhcholestancoa x
has only substance units: false
is: CHEBI:15494
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: HMDB02159

metaM dgpi prot hs r
has only substance units: false
is: HMDB02925
type: Species
constant: false
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:53486
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR 3DSPHR
name: 3-Dehydrosphinganine reductase
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.102
product: MODEL1310110015#
reversible: false

metaM sebacid x
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
boundary condition: false
is: C08277
name: sebacicacid
is: HMDB00792

http://identifiers.org/biomodels.db/MODEL1310110015#_d9f0ed06_736d_4219_bab0_3b45be448a6a
initial amount: NaN
is: P33316
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: DUT
type: Species
is encoded by: hsa:1854
initial concentration: NaN

metaR M8MASNterg
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
reactant: MODEL1310110015#
name: m8masn transport from ER to Golgi apparatus
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
fast: false
kinetic law: MODEL1310110015#

metaR r0841
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.1.1.271
fast: false
modifier: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
reversible: true

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM his L m
is: SBO:0000247
name: L-histidine
is: CHEBI:15971
is: HMDB00177
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaM idp n
constant: false
initial concentration: 1.0
is: HMDB03335
is: CHEBI:58280
name: IDP(3-)
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false

metaR PIt8
is described by: ECO:0000006
kinetic law: MODEL1310110015#
name: phosphate transport in/out via Na+ symporter
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM 2hb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
boundary condition: false
is: CHEBI:1148
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00008

metaR G14T20g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
reversible: false

metaR PGMT
is version of: http://identifiers.org/ec-code/5.4.2.2
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000176
name: phosphoglucomutase
fast: false
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d71ef767_b99a_4008_9045_526c0ea864d9
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:108
has only substance units: false
initial concentration: NaN
is: Q71UM8
name: ADCY2
initial amount: NaN
type: Species

metaR FAOXC102C103m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b81b26db_9717_45cc_8674_b7156ef87150
initial amount: NaN
type: Species
constant: false
name: _AA177072_1_c
is encoded by: hsa:AA177072
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1292
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true

metaM aps c
initial concentration: 1.0
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial amount: NaN
is: HMDB01003
name: 5'-adenylyl sulfate(2-)
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58243

metaR r2338
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reversible: true
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000

metaM 3hpcoa m
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
is: CHEBI:58528
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial amount: NaN

metaR r2124
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
type: Reaction

metaR AG13T13g
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110015#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#

metaM HC00229 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
initial amount: NaN
constant: false
is: SBO:0000247
name: Isomaltose
is: CHEBI:28189
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_d7503915_76d7_4c7e_9420_b2f69638c059
name: SC5DL
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6309
constant: false
boundary condition: true
is: Q6GTM5
has only substance units: false

metaM prostge2 c
name: prostaglandin E2(1-)
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
is: HMDB01220
has only substance units: false

metaM pyr c
is: SBO:0000247
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1
type: Species
initial amount: NaN
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
is: C00022
initial concentration: 1.0
constant: false
is: CHEBI:15361
has only substance units: false

metaM nadp c
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
constant: false
type: Species
is: C00006
is: HMDB00217
is: CHEBI:58349

http://identifiers.org/biomodels.db/MODEL1310110015#_3f133a25_c62d_4805_ac4d_f4a80c9e92a7
initial concentration: NaN
is: P08236
name: GUSB
is encoded by: hsa:2990
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM hspg e
type: Species
boundary condition: false
is: CHEBI:32366
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate proteoglycan
is: SBO:0000247
has only substance units: false
is: HMDB02259

http://identifiers.org/biomodels.db/MODEL1310110015#_96addeac_11fc_426a_8148_7a76c6070369
name: PIP5K1A
type: Species
initial concentration: NaN
is encoded by: hsa:8394
is: Q99755
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_9dac6426_0dc9_46b6_a9d1_8c0aa58c30b8
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: _AU149534_1_c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AU149534

metaR r2123
reversible: true
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR r0629
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.22
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176

metaM 2hb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:1148
initial amount: NaN
is: HMDB00008
name: 2-Hydroxybutyrate
boundary condition: false
initial concentration: 1.0

metaR EX 34hpp
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM HC01118 r
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57310
has only substance units: false
is: SBO:0000247
name: presqualene diphosphate(3-)
type: Species
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
boundary condition: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM pe hs e
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
constant: false
name: phosphatidylethanolamine
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r1847
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0b6ebe00_1230_4579_88c9_8efab357a310
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:56913
name: C1GALT1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9NS00

http://identifiers.org/biomodels.db/MODEL1310110015#_12b3ca5c_3a35_4cf1_9c77_782cf538e6e7
is encoded by: hsa:107
name: ADCY1
is: Q08828
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaM dgmp c
constant: false
is: C00362
is: SBO:0000247
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
initial amount: NaN
is: CHEBI:57673
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR SPRMTDe
fast: false
name: absorption for spermine across the basolateral side
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.

metaR r1156
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: true
product: MODEL1310110015#

metaM orot c
boundary condition: false
constant: false
has only substance units: false
is: C00295
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
is: HMDB00226
is: SBO:0000247
type: Species
name: Orotate
is: CHEBI:30839

metaR r1433
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
fast: false
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_246bd2a3_5ccb_48d7_8f3f_6903b206b273
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6480
initial concentration: NaN
name: ST6GAL1
is: B2R513
boundary condition: true
has only substance units: false
constant: false

metaR r2357
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaM arachd c
type: Species
has only substance units: false
name: arachidonate
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaM dolmanp L r
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15809
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species

metaM lanost r
initial concentration: 1.0
has only substance units: false
name: lanosterol
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01251
is: SBO:0000247
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: CHEBI:16521

metaM dd3coa x
is: SBO:0000247
initial concentration: 1.0
is: HMDB04257
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
name: 3-dodecenoylcoa
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_51681524_522b_46d1_bcc9_8b3c33c9c10f
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3155
is: Q6IBC0
initial amount: NaN
boundary condition: true
name: HMGCL
type: Species
is: SBO:0000252
constant: false

metaM fprica c
type: Species
is: CHEBI:58467
is: C04734
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
constant: false
is: HMDB01439

metaM HC00900 c
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
boundary condition: false
is: CHEBI:30860
has only substance units: false
constant: false
name: Methylmalonate
is: SBO:0000247
initial amount: NaN
type: Species

metaR HAS2
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase

metaR r1155
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is: SBO:0000185
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
type: Reaction

metaM mthgxl c
constant: false
initial amount: NaN
is: HMDB01167
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17158

metaM citr L c
is: CHEBI:16349
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00904
has only substance units: false
is: SBO:0000247
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
constant: false

metaM cspg b l
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02183
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:36005
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
initial concentration: 1.0

metaR r2358
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
reversible: true

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_eb34545e_310a_4013_8054_f905055caa47
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AW299740
name: _AW299740_1_m
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_e2e12be4_1beb_4259_93dc_67e2cd721ab0
initial concentration: NaN
is: SBO:0000252
name: LEFTY1
is encoded by: hsa:10637
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: O75610

metaM xol7ah2 c
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
has only substance units: false
is: SBO:0000247
is: CHEBI:28047
is: HMDB06893
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_94aedc65_185c_475d_9602_75301b06874f
initial amount: NaN
type: Species
is encoded by: hsa:2182
has only substance units: false
is: O60488
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: ACSL4

metaR DSREDUCr
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Desmosterol reductase
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110015#

metaM tridcoa m
type: Species
has only substance units: false
is: HMDB13109
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: tridecanoylcoa
initial amount: NaN

metaR GK1
fast: false
is described by: ECO:0000269
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)

metaR S6T6g
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_debdf782_122e_44cd_9ae3_139f8ee030b6
has only substance units: false
name: SLC22A1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O15245
constant: false
is encoded by: hsa:6580

http://identifiers.org/biomodels.db/MODEL1310110015#_1a147b8b_a4c9_4264_946e_8e29e52be79c
constant: false
boundary condition: true
type: Species
name: _R06874_1_r
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:R06874
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_4c146a78_4e3a_4bef_8c10_34c5dc50c375
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6534
name: SLC6A7
initial amount: NaN
is: Q99884
initial concentration: NaN

metaM sucr e
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00089
constant: false
name: Sucrose
is: HMDB00258
type: Species
has only substance units: false

metaM orot e
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
is: HMDB00226
initial concentration: 1.0
name: orotate
is: SBO:0000247
is: CHEBI:30839
type: Species
constant: false

metaR FOLR2
reversible: false
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110015#
name: folate reductase
kinetic law: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254

metaR SUCOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110015#
fast: false
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
name: Succinate--CoA ligase (GDP-forming)

metaM ksii core2 pre9 g
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28067
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ff721c3b_7c16_4729_82b7_801bd9faa8b4
constant: false
name: ENTPD2
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:954
is: Q5SPY7
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_51d8ea80_3802_41b2_b2ba_cee62485bfa6
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:275
name: AMT
initial concentration: NaN
is: P48728
constant: false
has only substance units: false

metaR r1431
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110015#

metaR r2359
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185

metaR COt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
name: CO transporter via diffusion
reversible: true
product: MODEL1310110015#

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR DOPABMO
fast: false
name: dopamine beta-monooxygenase
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.17.1
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM arachd e
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:32395
is: HMDB01043
type: Species
name: arachidonate

metaM sebacid c
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C08277
name: sebacicacid
is: HMDB00792
type: Species

metaR FUCASEly
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
name: alpha-fucosidase, lysosomal
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#

metaM mthgxl e
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: methylglyoxal
is: HMDB01167
is: CHEBI:17158
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR RE3567C
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3567
reversible: true
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#

metaR r0630
reactant: MODEL1310110015#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
product: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#

metaM m6masnC g
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H97N2O45X CHARGE: 0
type: Species
constant: false
is: HMDB00573
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:30825

http://identifiers.org/biomodels.db/MODEL1310110015#_26e85459_9afd_439b_9137_71a85708a804
type: Species
has only substance units: false
is encoded by: hsa:55902
is: SBO:0000252
is: Q5QPH3
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ACSS2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b5e0fd05_9aca_42cf_a7a8_a5926fabf42f
is: Q9UIG8
is: SBO:0000252
name: SLCO3A1
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:28232
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_40152f7f_02d4_43fa_9748_a742df5a4e1c
is encoded by: hsa:5315
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P14618
name: PKM2

metaR PRPPS
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: phosphoribosylpyrophosphate synthetase
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6a1b69b1_15d8_4f53_8f01_020ef6b53e1e
initial amount: NaN
boundary condition: true
type: Species
name: _NM_013421_1_m
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:NM 013421
is: SBO:0000252

metaM pro L e
is: CHEBI:17203
is: HMDB00162
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaR RDH2a
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (9-cis,NADPH)
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction
reversible: true

metaM HC01361 e
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
name: Dihydroneopterin
is: CHEBI:17001
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR EX thyox L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Thyroxine exchange
type: Reaction

metaM 3bcrn e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: C14143
is: HMDB04047
notes: FORMULA: C11H21NO5 CHARGE: 0
name: 3-hydroxy butyryl carnitine
is: SBO:0000247

metaR ASNtN1
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
fast: false
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269

metaR r0633
reversible: true
fast: false
is: SBO:0000176
type: Reaction
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.3

http://identifiers.org/biomodels.db/MODEL1310110015#_03ba76df_91cb_4724_b28f_08bf7e1d3080
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:204
name: AK2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P54819
constant: false

metaM tdcoa c
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
constant: false
has only substance units: false
is: C02593
type: Species
is: SBO:0000247
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57385

http://identifiers.org/biomodels.db/MODEL1310110015#_dadd52f6_8041_42f5_8b4c_5b84fb1fd484
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CA12
constant: false
is: O43570
type: Species
is encoded by: hsa:771

metaR r2353
product: MODEL1310110015#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM c10dc x
initial concentration: 1.0
is: C14143
name: sebacoyl carnitine
initial amount: NaN
constant: false
boundary condition: false
is: HMDB04047
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C17H30NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110015#_7856266b_b05f_4dd7_8c46_2cc658d8810c
boundary condition: true
name: PYCRL
initial amount: NaN
has only substance units: false
is: Q53H96
is: SBO:0000252
type: Species
is encoded by: hsa:65263
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_849b42be_2b59_48b1_b841_dbc54bae7853
has only substance units: false
is: F5GZG6
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:27010
name: TPK1
type: Species
boundary condition: true
initial amount: NaN

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
modifier: MODEL1310110015#
type: Reaction

metaM 3aib m
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
is: CHEBI:33094
has only substance units: false
name: (S)-3-aminoisobutyric acid
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02166

metaR NDP7g
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110015#
fast: false

metaR r2443
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_d1b1f99d_f82e_4123_9c0d_568768d96216
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: B3GALT5
is encoded by: hsa:10317
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r1906
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185

metaM caro e
has only substance units: false
name: beta-carotene
is: SBO:0000247
is: CHEBI:17579
boundary condition: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
initial amount: NaN
constant: false
is: HMDB00561
initial concentration: 1.0
type: Species

metaR r2354
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_0be8a7f2_dff9_4935_871b_88d95fcd641b
has only substance units: false
boundary condition: true
is: P47895
is encoded by: hsa:220
type: Species
constant: false
name: ALDH1A3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR RE3347C
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
name: RE3347
is described by: ECO:0000000

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR DGULND
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_00dfa47d_ba96_4ed4_88c3_65e2075d2b78
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM gm3 hs g
is: CHEBI:60065
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
constant: false

metaR SBTD D2
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.14
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: D-sorbitol dehydrogenase (D-fructose producing)
fast: false
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
modifier: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR AKR1D
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_01c60875_cb39_4648_919b_a9f6a61fe96d
is: Q70HW3
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:115286
name: SLC25A26
constant: false

metaR r0954
kinetic law: MODEL1310110015#
fast: false
name: MCT 1 Transport reaction
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_4a15605a_9034_4ff9_b1ec_0c45aba005f1
initial concentration: NaN
is encoded by: hsa:257202
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: GPX6
has only substance units: false
is: P59796

metaM glx x
is: HMDB00119
initial concentration: 1.0
is: CHEBI:36655
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
name: glyoxylate

metaR RETFA
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110015#
name: retinol acyltransferase

metaM nadp m
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58349
is: HMDB00217
type: Species
is: C00006
is: SBO:0000247
boundary condition: false

metaR r1903
name: Y+LAT2 Utilized transport
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7dec4c12_b258_46c9_b68a_1b05de292831
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLA2G4A
initial amount: NaN
boundary condition: true
is: P47712
is encoded by: hsa:5321

metaM dgmp e
is: CHEBI:57673
initial concentration: 1.0
initial amount: NaN
name: dGMP(2-)
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
boundary condition: false
is: HMDB01044
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_dc9dd5f2_773f_46e7_84b3_ae2b844a0728
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P42336
constant: false
initial concentration: NaN
is encoded by: hsa:5290
type: Species
name: PIK3CA
boundary condition: true

W3 CDTF: Fri Aug 31 03:30:00 BST 2012

metaM pro L c
initial amount: NaN
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: HMDB00162
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR DCATDc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the cell by diffusion
type: Reaction

metaR r2355
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM hs deg24 l
boundary condition: false
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
name: GlcNAc-GlcA-(Gal)2-Xyl
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H50NO26 CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7d1af08a_4309_4f6d_9ac8_ea29c690f4fd
is: P00441
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6647
initial amount: NaN
name: SOD1

metaR r1435
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Transport reaction
reversible: false
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110015#
name: adenosine 3',5'-bisphosphate Golgi transport

metaM his L e
constant: false
initial concentration: 1.0
is: CHEBI:15971
type: Species
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM 3bcrn c
initial concentration: 1.0
is: HMDB04047
initial amount: NaN
notes: FORMULA: C11H21NO5 CHARGE: 0
is: SBO:0000247
has only substance units: false
name: 3-hydroxy butyryl carnitine
boundary condition: false
constant: false
type: Species
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110015#_6de2755b_cf2f_425c_b94a_20807be1ea6a
type: Species
boundary condition: true
is encoded by: hsa:54344
constant: false
is: Q9P2X0
name: DPM3
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_07808159_2109_43ec_b5b8_0b3977111a85
initial amount: NaN
is: SBO:0000252
type: Species
is: Q86VV3
constant: false
boundary condition: true
name: ENTPD1
is encoded by: hsa:953
initial concentration: NaN
has only substance units: false

metaM pmtcrn m
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00222
name: L-palmitoylcarnitine
initial concentration: 1.0
is: CHEBI:17490
initial amount: NaN
boundary condition: false
type: Species

metaR HISSNAT5tc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR SUCD1m
name: succinate dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000134
modifier: MODEL1310110015#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110015#

metaR GALASE12ly
product: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110015#_84f62feb_6bcf_43da_b1b1_801b1a435ffa
is: SBO:0000252
type: Species
name: PPT2
initial concentration: NaN
is: Q9UMR5
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:9374
initial amount: NaN

metaR r0634
is: SBO:0000176
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110015#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_31a48390_87ff_4438_a583_9c10656b0b81
constant: false
name: GCK
is encoded by: hsa:2645
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P35557

metaR 2OXOADOXm
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.61
is described by: ECO:0000304
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

metaM caro c
is: SBO:0000247
constant: false
has only substance units: false
name: beta-carotene
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
is: HMDB00561
initial concentration: 1.0
is: CHEBI:17579

metaM odecoa m
is: CHEBI:57387
initial amount: NaN
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
constant: false
type: Species
is: HMDB01322
has only substance units: false
initial concentration: 1.0

metaR r2356
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110015#

metaR r0055
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000000
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
reactant: MODEL1310110015#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.7

metaR FUMtm
fast: false
modifier: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is: SBO:0000185
name: fumarate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_242c11e9_85de_4ab6_9f68_e079724d204b
type: Species
is: SBO:0000252
is: Q8WWX8
name: SLC5A11
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:115584
constant: false
has only substance units: false

metaR r1434
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_a16085ea_48b5_4e77_be3a_ab65f5bfc1fd
initial amount: NaN
name: PCYT1A
is: P49585
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5130

metaM his L c
type: Species
name: L-histidine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
is: CHEBI:15971
is: HMDB00177
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_2a1f1f52_b200_4ee4_8e6d_35a50a2e3611
is encoded by: hsa:4598
type: Species
initial concentration: NaN
is: SBO:0000252
is: B2RDU6
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: MVK

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110015#
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:

metaR RE2998M
is: SBO:0000176
name: RE2998
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaM arachd l
initial concentration: 1.0
has only substance units: false
is: HMDB01043
name: arachidonate
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
is: SBO:0000247

metaM xyl D c
has only substance units: false
is: CHEBI:15936
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
initial amount: NaN
constant: false
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110015#_c0c640a9_7ea7_4a34_88dc_99da572ff068
constant: false
is: P11182
is: SBO:0000252
name: DBT
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:1629
boundary condition: true
initial concentration: NaN

metaM odecoa c
is: CHEBI:3793
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaR DOLPH Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false

metaR 2AMADPTm
modifier: MODEL1310110015#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110015#
fast: false

metaR r0523
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
product: MODEL1310110015#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
modifier: MODEL1310110015#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM ksii core2 pre7 g
constant: false
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C67H108N5O51SX CHARGE: -2
type: Species

metaR NACHEX9ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110015#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_2d0e90f5_682f_4150_9b6f_f293af40098f
has only substance units: false
constant: false
is: B4DDW0
is encoded by: hsa:51109
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: RDH11
boundary condition: true

metaM CE4792 m
has only substance units: false
is: CHEBI:57923
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
name: 3-oxo-cis-8-tetradecenoyl-CoA
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

W3 CDTF: Fri Aug 31 03:30:00 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110015#_d5faf14d_6656_4600_9541_1f36ecfe1be9
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:5289
is: SBO:0000252
has only substance units: false
name: PIK3C3
type: Species
is: Q8NEB9

http://identifiers.org/biomodels.db/MODEL1310110015#_80308612_5841_4703_9993_fdd08d3982af
name: HK1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3098
type: Species
boundary condition: true
initial amount: NaN
is: A8K7J7
constant: false
has only substance units: false

metaM ksii core4 pre8 g
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: HMDB00175
initial concentration: 1.0
type: Species
name: keratan sulfate II biosynthesis, precursor 8
boundary condition: false
initial amount: NaN
is: C00130
is: CHEBI:58053

metaR NDP7er
is described by: ECO:0000000
fast: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
reactant: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR S23T4g
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.99.4
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_1b769fcb_8667_46f6_9357_702cc2bee548
is encoded by: hsa:AA854479
type: Species
initial amount: NaN
initial concentration: NaN
name: _AA854479_1_m
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR P45027A1m
name: Cytochrome P450 27
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5bcdbf6b_7c03_4655_a1ca_fe54dbf151fb
type: Species
constant: false
name: SLC8A3
has only substance units: false
is encoded by: hsa:6547
initial amount: NaN
initial concentration: NaN
is: B3KU59
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_18e4a079_f4f6_458c_b8b1_dbd3796e1b68
is: SBO:0000252
is encoded by: hsa:29920
constant: false
initial amount: NaN
has only substance units: false
is: Q96C36
boundary condition: true
type: Species
name: PYCR2
initial concentration: NaN

metaM CE5854 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
constant: false
type: Species
is: CHEBI:27485
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02710
name: gama-CEHC-glucuronide

http://identifiers.org/biomodels.db/MODEL1310110015#_82afa9d5_2d97_460b_946c_4cbb37cbbaea
constant: false
boundary condition: true
type: Species
name: NME7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:29922
has only substance units: false

metaM uri c
is: SBO:0000247
name: Uridine
initial amount: NaN
boundary condition: false
is: C00299
initial concentration: 1.0
is: CHEBI:16704
constant: false
is: HMDB00296
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species

metaM pmtcrn r
is: SBO:0000247
type: Species
is: HMDB00222
initial concentration: 1.0
constant: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
initial amount: NaN
name: L-palmitoylcarnitine
has only substance units: false

metaR r0051
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
product: MODEL1310110015#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:

metaR r2352
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
product: MODEL1310110015#
type: Reaction
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM hco3 e
is: HMDB00595
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: C00288
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
type: Species
initial concentration: 1.0
name: Bicarbonate

metaM cspg b e
is: SBO:0000247
initial amount: NaN
is: HMDB00300
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:17568
is: C00106
boundary condition: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
has only substance units: false
constant: false
type: Species

metaR NACHEX22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#

metaR FAS80COA L
reversible: false
is described by: ECO:0000269
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d3209286_bde7_49f1_828f_117527f772fe
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: ALDH4A1
type: Species
is: SBO:0000252
is encoded by: hsa:8659

metaM m7mpdol U r
is: CHEBI:37636
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
boundary condition: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d91a9155_ae5d_40cd_887d_5b2b6bc53a0d
initial amount: NaN
constant: false
is encoded by: hsa:953
name: ENTPD1
is: Q86VV3
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_2f0c5cab_9609_4662_9c98_387a26375cbb
initial amount: NaN
is encoded by: hsa:8693
type: Species
boundary condition: true
is: Q8N4A0
name: GALNT4
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM 3aib c
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02166
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
initial amount: NaN
is: CHEBI:33094
name: (S)-3-aminoisobutyric acid

metaR r2200
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_6010503a_ad4d_48d8_9e04_e668bbcdb177
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5372
constant: false
is: A8K003
is: SBO:0000252
name: PMM1
initial concentration: NaN

metaM pro L m
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17203
is: HMDB00162
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_a3740ba3_73dc_4c4e_8f48_1c2459f061bb
type: Species
initial concentration: NaN
constant: false
name: PIGF
has only substance units: false
initial amount: NaN
is: Q6IB04
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5281

http://identifiers.org/biomodels.db/MODEL1310110015#_44f37a26_6c60_4181_80f7_7ca719d3302b
is encoded by: hsa:10005
constant: false
has only substance units: false
initial amount: NaN
is: O14734
is: SBO:0000252
name: ACOT8
initial concentration: NaN
boundary condition: true
type: Species

metaM 2dr1p c
type: Species
has only substance units: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: SBO:0000247
constant: false
is: CHEBI:58576
is: HMDB01351
name: 2-Deoxy-D-ribose 1-phosphate
initial amount: NaN
is: C00672
boundary condition: false
initial concentration: 1.0

metaR S6TASE19ly
type: Reaction
product: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false

metaR r1589
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_cb3c05f9_27bb_4527_ba29_a98580fda21c
is encoded by: hsa:3418
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: P48735
type: Species
name: IDH2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_255c166e_4f6b_4292_a168_6b0b89ee359b
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2348
initial concentration: NaN
type: Species
boundary condition: true
name: FOLR1

metaM ksi pre26 g
constant: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
type: Species
is: CHEBI:28067
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 26
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM pmtcrn x
initial amount: NaN
is: CHEBI:17490
boundary condition: false
name: L-palmitoylcarnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
type: Species
constant: false
is: HMDB00222

metaR r2201
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
fast: false

metaM uri e
initial amount: NaN
type: Species
is: HMDB00296
is: CHEBI:16704
boundary condition: false
is: C00299
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Uridine
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

metaR GLYCLTtp
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false
name: glycolate transport into peroxisome
fast: false

metaR CHAT
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
fast: false
type: Reaction

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
name: deoxyguanylate kinase (dGMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
reactant: MODEL1310110015#
product: MODEL1310110015#

metaM hco3 c
is: CHEBI:17544
is: HMDB00595
name: Bicarbonate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false

metaM nadp r
is: C00006
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
constant: false
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58349
is: HMDB00217
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5c6d590b_7ef0_41a1_989f_3d5a9d56001f
name: NDUFA13
is encoded by: hsa:51079
is: Q9P0J0
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_eae9072c_76ed_4b99_b78f_e8156d3f8aa0
has only substance units: false
is encoded by: hsa:11282
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: MGAT4B

metaR r2202
fast: false
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0522
product: MODEL1310110015#
reversible: false
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#

metaM memgacpail hs r
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15809
is: SBO:0000247
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
constant: false

metaR r1588
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185

metaM cholp c
boundary condition: false
is: CHEBI:295975
initial amount: NaN
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247
name: choline phosphate(1-)
type: Species
initial concentration: 1.0
has only substance units: false

metaR RE0935E
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
name: RE0935
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR THYPX
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.8
is: SBO:0000176
name: thyroid peroxidase
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.7 Confidence Level: 4 AUTHORS: PMID:3153466,PMID:3475693 NOTES:NCD

metaR r1154
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
name: EC:1.2.7.2

metaM 3aib e
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: HMDB02166
name: (S)-3-aminoisobutyric acid
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaM tetpent6coa x
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
initial amount: NaN
type: Species
is: C16172
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_dc44a23c_5305_444a_a9a8_e058479dec5e
is: P49327
initial concentration: NaN
is encoded by: hsa:2194
boundary condition: true
name: FASN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaM arachd r
is: SBO:0000247
is: HMDB01043
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: arachidonate
is: CHEBI:32395
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

metaR RE3524R
name: RE3524
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
product: MODEL1310110015#
fast: false
reversible: true

metaR ECOAH12m
product: MODEL1310110015#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM xyl D e
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
name: aldehydo-D-xylose

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_fae9de93_f45a_470b_b3d1_a57ec9e0488d
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: NOS1
is: SBO:0000252
is encoded by: hsa:4842
initial amount: NaN
is: B4DG68

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM citr L e
is: SBO:0000247
name: citr_L[e]
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16349
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
boundary condition: false

metaR HGNTOR
product: MODEL1310110015#
reactant: MODEL1310110015#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110015#
fast: false

metaR r0747
product: MODEL1310110015#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110015#
is described by: ECO:0000000
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
type: Reaction
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_4ab545d8_8516_4b2c_8548_de839541877f
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:57030
has only substance units: false
initial concentration: NaN
is: Q9P2U7
name: SLC17A7
constant: false

metaR DESAT24 1
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: false
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
fast: false
is described by: ECO:0000269

metaM pram c
is: C03090
constant: false
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58681
type: Species
is: SBO:0000247
is: HMDB01128
initial amount: NaN

metaM udpg c
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
is: CHEBI:58367
constant: false
name: UDPglucose
is: HMDB00286
type: Species
has only substance units: false
is: SBO:0000247
is: C00029
initial concentration: 1.0

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaM occoa m
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: C01944
boundary condition: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
has only substance units: false

metaR CMPSAS
kinetic law: MODEL1310110015#
name: CMP sialic acid synthase
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
fast: false
reactant: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4bbaaf56_1279_4560_8d07_6939d4eca524
has part: P48201
is encoded by: hsa:518
initial concentration: NaN
is: SBO:0000297
constant: false
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
initial amount: NaN
has only substance units: false

metaR ARACHDt2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110015#
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r2132
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_58641175_6c61_445d_b363_680b73be97c4
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6649
is: P08294
constant: false
name: SOD3
boundary condition: true

metaM 11 cis retfa e
name: fatty acid 11-cis-retinol
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB00224
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: CHEBI:58190
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6efb86e4_1459_4c40_b04a_dd8df675a877
initial concentration: NaN
type: Species
name: SLC8A3
is encoded by: hsa:6547
is: Q96QG2
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaM lys L m
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:32551
has only substance units: false
initial amount: NaN
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110015#_bcf7ce7b_3ac6_469f_a24d_5b6fdd4a2ea3
constant: false
is encoded by: hsa:5860
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P09417
name: QDPR
type: Species
initial amount: NaN

metaR KAS8
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110015#
type: Reaction

metaR r1597
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false

metaR r0741
is described by: ECO:0000000
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110015#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d3f1a5e8_863e_4846_833a_0a1d3ebaf7d2
name: NMNAT2
boundary condition: true
constant: false
is encoded by: hsa:23057
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM ksi pre18 g
name: keratan sulfate I biosynthesis, precursor 18
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: C00130
is: CHEBI:58053
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: HMDB00175
has only substance units: false
initial amount: NaN

metaM glx c
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
name: glyoxylate
is: SBO:0000247
constant: false
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:36655
is: HMDB00119

metaR NACHEX25ly
reversible: false
fast: false
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_96d904fc_01e1_43d7_aa4c_6ddf25e37ec2
is: SBO:0000252
type: Species
is encoded by: hsa:84649
initial amount: NaN
is: Q96PD7
name: DGAT2
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM fald e
name: formaldehyde
is: HMDB01426
boundary condition: false
initial concentration: 1.0
is: CHEBI:16842
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_ff0135d4_4597_423f_80f7_b96354a24bd3
is: Q9NT06
constant: false
is encoded by: hsa:54511
name: HMGCLL1
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR HEX1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucose:ATP)
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM acald m
is: HMDB00990
is: CHEBI:15343
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a86bd303_d652_4345_97f4_a0329e44b463
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: ABCD1
type: Species
is: SBO:0000252
is: P33897
has only substance units: false
is encoded by: hsa:215

metaM lys L n
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
is: HMDB00182
has only substance units: false
name: L-lysinium(1+)
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR r2131
modifier: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
name: cytidylate kinase (dCMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_f099b2ec_362e_4a0c_9759_ea775e3cb1ec
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: _AA021081_1_r
is encoded by: hsa:AA021081
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_1dfea07a_8fda_4b35_9a59_f04ba60eedec
is: B2RB13
has only substance units: false
constant: false
is encoded by: hsa:23305
initial amount: NaN
name: ACSL6
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR PPPG9tm
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#
name: protoporphyrinogen IX mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567

metaR r1598
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaM udpg e
is: CHEBI:58367
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
is: HMDB00286
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ad71bb93_7c30_420e_a856_0b4fbc5e9d81
type: Species
boundary condition: true
is: Q8N3E9
has only substance units: false
name: PLCD3
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:113026

metaM hco3 m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17544
is: HMDB00595
name: Bicarbonate
has only substance units: false
constant: false

metaR r0743
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
constant: false
type: Species
name: 3,4-Dihydroxymandelaldehyde
boundary condition: false
is: C05577
is: HMDB06242
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR r1595
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_0aac5b61_d6a6_45ec_8644_05108a272ecd
is: SBO:0000252
boundary condition: true
is: Q9NUQ2
has only substance units: false
name: AGPAT5
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:55326
constant: false

metaM fald c
type: Species
initial concentration: 1.0
name: formaldehyde
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: CHEBI:16842
is: HMDB01426
initial amount: NaN

metaM pail4p hs n
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4d3f70ac_29e7_4f2f_b094_ec2fb2cef472
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: ACOT8
is: O14734
type: Species
is encoded by: hsa:10005

metaR NICRNS
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reversible: false
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
name: NICRNS

metaR r0744
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is: SBO:0000176
product: MODEL1310110015#
reversible: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
fast: false
is described by: ECO:0000000

metaR FATP3t
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110015#
name: fatty acid electroneutral transport

metaM Ser Thr l
is: CHEBI:37568
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: C00459
is: SBO:0000247
is: HMDB01342
boundary condition: false

metaM g3m8masn r
initial concentration: 1.0
is: C05873
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
boundary condition: false
constant: false

metaR r2133
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110015#_c877e5b8_6766_46b2_b45f_ed66f8e83a8f
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: GPX7
constant: false
type: Species
is encoded by: hsa:2882
is: Q96SL4
is: SBO:0000252

metaR r1596
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
fast: false
type: Reaction
kinetic law: MODEL1310110015#

metaR HEX4
type: Reaction
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
product: MODEL1310110015#
name: hexokinase (D-mannose:ATP)
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_92cfeb8f_4f48_4a83_8b72_042978fc63e0
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:229
is: P05062
name: ALDOB
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_3cfbb091_087a_4145_9188_5061e7b07201
type: Species
name: SLC25A2
boundary condition: true
is encoded by: hsa:83884
constant: false
is: SBO:0000252
is: Q9BXI2
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM 5HPET c
is: CHEBI:57450
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
is: HMDB01193
is: SBO:0000247
type: Species
name: 5(S)-HPETE(1-)
has only substance units: false

metaM cs e deg7 l
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3
boundary condition: false

metaR ORNDC
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.1.1.17
product: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is: SBO:0000176
name: Ornithine Decarboxylase
is described by: ECO:0000269

metaM 5tedtricoa m
boundary condition: false
name: 5,8,11-tetradecatrienoylcoa
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaM idour e
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
constant: false
name: L-iduronate
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02704
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5b0bec31_4ced_4cb2_b9cc_7f1d35d5579a
type: Species
is: O75356
constant: false
initial amount: NaN
name: ENTPD5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:957
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b0869357_7033_4bc7_8616_25f808782cf6
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3098
boundary condition: true
is: B3KXY9
name: HK1
initial concentration: NaN
initial amount: NaN

metaM gthrd r
constant: false
initial amount: NaN
is: CHEBI:57925
initial concentration: 1.0
is: HMDB00125
has only substance units: false
type: Species
name: glutathionate(1-)
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247

metaR r0527
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is described by: ECO:0000000
fast: false
product: MODEL1310110015#

metaM n4m2masn g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C66H109N6O45X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)4-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05881
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM xol27oh m
is: CHEBI:17703
boundary condition: false
name: 26-hydroxycholesterol
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

http://identifiers.org/biomodels.db/MODEL1310110015#_e402f4f7_8ddd_4b8b_ab8b_98a31762107c
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:594
has only substance units: false
has part: Q9BQL0
name: DBT:DLD:BCKDHA:BCKDHB

metaR PYRt2m
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reactant: MODEL1310110015#
fast: false
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
type: Reaction

metaR NAGLCAly
type: Reaction
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
name: N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false

metaM dcmp c
constant: false
name: dCMP
is: SBO:0000247
is: HMDB01202
initial amount: NaN
is: C00239
is: CHEBI:57566
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM ksii core4 pre2 g
type: Species
is: HMDB00175
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
name: keratan sulfate II boisynthesis, precursor 2
is: CHEBI:58053
constant: false
boundary condition: false
is: C00130
initial concentration: 1.0

metaR RE1342C
name: RE1342
kinetic law: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reactant: MODEL1310110015#
is: SBO:0000176

metaR r1593
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110015#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_94a8d1b3_4ba8_4af5_a24a_27a0ed2e185d
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:218
is: SBO:0000252
type: Species
is: P30838
initial amount: NaN
name: ALDH3A1
boundary condition: true

metaM adrn c
is: HMDB02226
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
constant: false
name: adrenic acid
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:53487
initial concentration: 1.0

metaR RE1527M
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110015#

metaR r1594
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110015#
type: Reaction
fast: false
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACACt2
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
type: Reaction
reversible: true
name: acetoacetate transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_b718529a_d128_4e13_be78_7bef918cad49
has only substance units: false
initial amount: NaN
is encoded by: hsa:522
initial concentration: NaN
boundary condition: true
has part: Q6NZ59
constant: false
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
type: Species

metaR NDP7ex
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
reactant: MODEL1310110015#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), extracellular
type: Reaction
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:

metaR PRISTCOAtx
name: pristcoa peroxisomal transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_4b65f5d1_54a5_4af3_befd_bc4114fac1e5
is: Q8NFW8
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: CMAS
is encoded by: hsa:55907

http://identifiers.org/biomodels.db/MODEL1310110015#_f1724fee_47c1_49ed_80b8_2de12118d48a
name: COX4I2
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:84701
initial amount: NaN
is: SBO:0000252
is: Q96KJ9
boundary condition: true
has only substance units: false

metaR RE3000M
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
reversible: true
name: RE3000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false

metaM 4hexdtetcoa m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
constant: false
initial amount: NaN
name: 4,7,10,13-hexadecatetraenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b18840c1_4757_4c85_a302_82e15a7cd242
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O94925
name: GLS
is encoded by: hsa:2744
constant: false
has only substance units: false

metaM idour c
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:21338
is: HMDB02704
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
is: SBO:0000247
name: L-iduronate

metaR UAGDP
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.23
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f5e49e0b_7727_468d_98a2_5041536e22a4
constant: false
is encoded by: hsa:5095
has only substance units: false
boundary condition: true
name: PCCA
initial amount: NaN
is: C9JPQ8
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR HEX7
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
type: Reaction
product: MODEL1310110015#
name: hexokinase (D-fructose:ATP)

http://identifiers.org/biomodels.db/MODEL1310110015#_ac9babf6_a598_48c6_8b1a_4c134045184b
has only substance units: false
is: SBO:0000252
constant: false
name: BTD
initial amount: NaN
is: P43251
is encoded by: hsa:686
type: Species
boundary condition: true
initial concentration: NaN

metaR r1591
is described by: ECO:0000000
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_e82bcbd8_dd4a_49c2_b777_01f68e2ab0ab
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COX7A2
constant: false
boundary condition: true
is: H0UI06
is encoded by: hsa:1347
has only substance units: false
type: Species

metaM Ser Thr g
boundary condition: false
is: HMDB00645
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58336
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaR r2130
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
is described by: ECO:0000000

metaR XYLTt
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
name: Xylitol transport via passive diffusion
reversible: true
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_340c5545_4e5b_478d_a332_fd34913fda27
type: Species
initial concentration: NaN
is encoded by: hsa:522
is: SBO:0000297
has part: Q6IB54
constant: false
boundary condition: true
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN

metaR FAOXC101m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR PROSTGF2t
product: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000269
name: prostaglandin uniport
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110015#_fc24284f_dd70_42b7_a7d6_3304d2b63ba8
name: ME2
boundary condition: true
constant: false
is: P23368
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4200

metaM xyl D l
constant: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: aldehydo-D-xylose
initial amount: NaN
is: CHEBI:15936

metaR PI4PLC
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110015#
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#

metaM adrn e
is: SBO:0000247
boundary condition: false
is: CHEBI:53487
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
is: HMDB02226
type: Species
name: adrenic acid
has only substance units: false

metaR CO2t
product: MODEL1310110015#
fast: false
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
name: CO2 transporter via diffusion
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110015#

metaR r1592
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

metaM atp x
is: HMDB00538
boundary condition: false
name: ATP(4-)
type: Species
has only substance units: false
is: C00002
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57299
is: SBO:0000247

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR C10DCc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR SARCStex
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
name: Sarcosine transport (extracellular to cytosol)
fast: false
kinetic law: MODEL1310110015#
reversible: false
type: Reaction

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaM C05957 r
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB02710
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
boundary condition: false
initial amount: NaN
name: Prostaglandin J2
constant: false
initial concentration: 1.0

metaR TMDK1
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
name: thymidine kinase (ATP:thymidine)
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176

metaM 34dhmald m
is: C05577
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: SBO:0000247
is: HMDB06242
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
constant: false
type: Species

metaR RE3346M
reversible: true
name: RE3346
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176

metaR FAOXC164GC163m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM for c
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
constant: false
name: Formate
is: CHEBI:15740
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_fdd7f179_8d48_4c5c_b1be_96227f0e26c6
type: Species
is encoded by: hsa:1629
name: DBT
is: P11182
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_fcfb03f3_bb45_4ed4_a1cf_b9d4cfef3ba2
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ATP2B3
is: Q16720
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:492

metaR RE1516M
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: RE1516
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR HSPGtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
name: heparan sulfate transport, extracellular to lysosome
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_0c7080f9_68c7_48df_9889_cf3952005560
is: P00505
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2806
name: GOT2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM Tn antigen g
boundary condition: false
type: Species
name: Tn antigen
is: C04383
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0

metaM lys L e
is: CHEBI:32551
is: SBO:0000247
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
type: Species
initial amount: NaN
name: L-lysinium(1+)
constant: false
has only substance units: false

metaR r2435
reversible: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110015#

metaM acald e
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: CHEBI:15343
is: SBO:0000247
is: HMDB00990
boundary condition: false
name: acetaldehyde

metaM lald L c
boundary condition: false
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial concentration: 1.0
is: CHEBI:18041
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03052
constant: false
name: (S)-lactaldehyde

metaR XYLUR
fast: false
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.10
reversible: true
name: xylulose reductase
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR LEUt5m
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
name: leucine mitochondrial transport
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction

metaR r1590
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_fddd7c46_f168_4823_87c7_dd7116735947
has only substance units: false
name: PRDX1
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5052
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d21f1cd2_65ac_40b1_8bae_39e544ff5621
name: HMOX1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3162
has only substance units: false
is: SBO:0000252
is: Q6FH11
type: Species

metaR ME2m
fast: false
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
is version of: http://identifiers.org/ec-code/1.1.1.40
reversible: false
kinetic law: MODEL1310110015#
name: malic enzyme (NADP), mitochondrial
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
modifier: MODEL1310110015#
is described by: ECO:0000000

metaR r2139
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true

metaR MMMm
name: methylmalonyl-CoA mutase
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is described by: ECO:0000269
reversible: true
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.99.2
type: Reaction
kinetic law: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_0fce55a5_22f6_46ac_8fb4_3d1a88a40dd2
initial amount: NaN
is encoded by: hsa:570
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: BAAT
is: Q14032
boundary condition: true
is: SBO:0000252

metaR RE1810M
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: RE1810
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:

metaR PYRt2r
is described by: ECO:0000269
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
name: pyruvate reversible transport via proton symport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaM c10dc c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C17H30NO6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: C14143
is: HMDB04047
name: sebacoyl carnitine

metaR DCATDr
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

metaR SPODMe
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
product: MODEL1310110015#
type: Reaction
name: superoxide dismutase, extracellular
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
reversible: false
fast: false

metaR RE2541E
reversible: true
type: Reaction
name: RE2541
is: SBO:0000176
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaR N3Tg
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.122
modifier: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110015#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110015#_c163a288_0759_43bb_bd9e_88931f4eaf99
has only substance units: false
is: SBO:0000252
is: P32322
is encoded by: hsa:5831
initial amount: NaN
constant: false
name: PYCR1
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_bdb33bc6_6823_4764_8142_eb3305a7d3d2
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: _22305_2_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22305

http://identifiers.org/biomodels.db/MODEL1310110015#_47b0e674_f7bd_4336_9f06_e777d8f57115
name: _642502_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:642502
has only substance units: false
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaR SIAASE2ly
is described by: ECO:0000000
name: sialidase, lysosomal
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
modifier: MODEL1310110015#
fast: false
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM lac D e
initial concentration: 1.0
is: CHEBI:16004
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01311
constant: false
is: SBO:0000247
name: (R)-lactate

metaR FAOXC121C101m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_9c73e43f_f31b_4f76_942d_1d9dbed40d2e
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: PIK3R1
initial concentration: NaN
initial amount: NaN
is: B3KT19
is encoded by: hsa:5295

metaM glx m
boundary condition: false
is: CHEBI:36655
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
is: SBO:0000247
has only substance units: false
is: HMDB00119
initial amount: NaN

metaM odecoa r
is: SBO:0000247
has only substance units: false
is: HMDB01322
constant: false
is: CHEBI:57387
type: Species
name: oleoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaR r0638
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
modifier: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1eeae448_38a9_4fd8_8990_a1e3fdc9c993
type: Species
name: CHAT
is: Q6LEN6
initial concentration: NaN
is encoded by: hsa:1103
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR r2437
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

http://identifiers.org/biomodels.db/MODEL1310110015#_409b87a5_bd05_4191_899a_609da8004317
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q4J699
constant: false
is encoded by: hsa:491
type: Species
initial amount: NaN
name: ATP2B2

metaR ALAR
name: alanine racemase
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000212

metaR DSAT
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
type: Reaction
name: dihydrosphingosine N-acyltransferase
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR PYRt2p
modifier: MODEL1310110015#
product: MODEL1310110015#
name: pyruvate peroxisomal transport via proton symport
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM retinol cis 11 c
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
constant: false
boundary condition: false
type: Species
has only substance units: false
name: 11-cis-retinol
is: SBO:0000247
is: HMDB06216
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_17ddc69f_0564_43e9_a70e_be9f98b46ed8
initial concentration: NaN
is: Q9NNW7
is: SBO:0000252
initial amount: NaN
constant: false
name: TXNRD2
is encoded by: hsa:10587
boundary condition: true
has only substance units: false
type: Species

metaR r1842
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185

metaR MHISOR
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
is: SBO:0000176
product: MODEL1310110015#

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
is: CHEBI:16004
boundary condition: false
type: Species
is: HMDB01311
initial amount: NaN
name: (R)-lactate
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r2439
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
fast: false

metaM Tn antigen l
type: Species
has only substance units: false
constant: false
name: Tn antigen
is: SBO:0000247
boundary condition: false
is: C04383
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0

metaM ksi pre1 g
boundary condition: false
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 1
initial amount: NaN
type: Species
notes: FORMULA: C79H129N5O57X CHARGE: -1
constant: false
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110015#_14cab5f7_eb31_4390_9375_e016043f2ea3
is: Q9NUB1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:84532
initial concentration: NaN
constant: false
name: ACSS1
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_b67d1892_cb18_4958_bdf5_2f06c96253db
is: SBO:0000297
has only substance units: false
has part: P08237
is encoded by: hsa:5213
boundary condition: true
name: PFKM:PFKP
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR GLCNACASE4ly
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
product: MODEL1310110015#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_7ef4bb45_8642_4dce_9dc2_8d44ad710f54
has only substance units: false
is encoded by: hsa:641372
initial concentration: NaN
name: ACOT6
is: Q3I5F7
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaR RE3011R
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:11368003,PMID:9799565,PMID:9862787 NOTES:
fast: false
type: Reaction
name: RE3011
reactant: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_d33b7d35_6c4f_4c38_b7cb_46f13675f63a
is encoded by: hsa:6184
has only substance units: false
initial amount: NaN
type: Species
is: P04843
constant: false
boundary condition: true
initial concentration: NaN
name: RPN1
is: SBO:0000252

metaM clpnd e
boundary condition: false
initial amount: NaN
is: CHEBI:53488
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: clupanodonic acid
is: HMDB06528
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

W3 CDTF: Fri Aug 31 03:29:59 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110015#_9b5a2b85_f3d0_4b7b_8af9_a927f25ad863
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9NSW9
is: SBO:0000252
is encoded by: hsa:6553
constant: false
name: SLC9A5
boundary condition: true
type: Species

metaM occoa x
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01070
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR S6T7g
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110015#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176

metaM 3mlda c
constant: false
type: Species
has only substance units: false
is: C05828
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
name: 3-Methylimidazoleacetic acid
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
is: HMDB02820
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_2748c74f_ee75_4124_9046_38d12670bae9
initial concentration: NaN
is: SBO:0000252
name: ARSB
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:411
boundary condition: true
is: A8K4A0
has only substance units: false

metaM 3decdicoa m
is: SBO:0000247
has only substance units: false
name: 3,7-decadienoylcoa
type: Species
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

W3 CDTF: Fri Aug 31 03:29:59 BST 2012

metaR AG13T12g
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110015#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
fast: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR FAOXC225m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM CE5161 r
has only substance units: false
initial concentration: 1.0
is: HMDB01509
is: SBO:0000247
is: CHEBI:57460
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA

metaM 11 cis retfa c
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: fatty acid 11-cis-retinol
is: HMDB06216
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:16302

metaM pail4p hs c
constant: false
is: CHEBI:58178
type: Species
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_47e5e2a1_ba8a_4cb1_b69e_94f98f229af0
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8818
boundary condition: true
constant: false
name: DPM2
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a6e0fbc6_250f_431f_9ec0_ac1185c01764
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:H77542
type: Species
name: _H77542_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM lys L c
type: Species
is: SBO:0000247
is: CHEBI:32551
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: HMDB00182
name: L-lysinium(1+)
has only substance units: false
initial amount: NaN
boundary condition: false

metaR FACOAL245 2
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
name: fatty-acid--CoA ligase
type: Reaction

metaM doco13ac e
initial amount: NaN
is: HMDB02068
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C22H41O2 CHARGE: -1
name: docosenoic acid (C22:1)
boundary condition: false

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
is: CHEBI:17759
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB00032
has only substance units: false
initial concentration: 1.0

metaR FTHFL
reversible: true
type: Reaction
kinetic law: MODEL1310110015#
name: Formate-tetrahydrofolate ligase
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5

http://identifiers.org/biomodels.db/MODEL1310110015#_f363be79_cbe7_4f70_b471_036c39c769cd
is: P37287
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: PIGA
initial concentration: NaN
is encoded by: hsa:5277
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_39ee05aa_f273_4cd0_82d4_166ec780b98f
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:515
initial amount: NaN
constant: false
name: ATP5F1
initial concentration: NaN
is: P24539
has only substance units: false

metaR r0853
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110015#
reversible: false
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_35b13992_7b25_4ef2_b09c_266b250d6ca7
is: Q9UHV8
has only substance units: false
is encoded by: hsa:29124
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: LGALS13
is: SBO:0000252

metaM idour l
constant: false
initial concentration: 1.0
name: L-iduronate
type: Species
boundary condition: false
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: CHEBI:21338
is: SBO:0000247
initial amount: NaN

metaR r2137
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
kinetic law: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d33ea198_87ba_4edf_976d_a3fde66d3ff9
is: P31939
is: SBO:0000252
name: ATIC
is encoded by: hsa:471
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

metaM xol27oh r
boundary condition: false
is: SBO:0000247
is: HMDB02103
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: CHEBI:17703
name: 26-hydroxycholesterol
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaM ksi deg16 l
is: CHEBI:16953
is: HMDB00812
initial concentration: 1.0
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 16

metaM retinal 11 cis c
constant: false
is: SBO:0000247
name: 11-cis-retinal
is: CHEBI:16066
is: HMDB02152
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_34df0710_a5a4_43fe_a8ba_d6ffb319b9b8
constant: false
has only substance units: false
boundary condition: true
name: SLC7A9
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:11136
initial amount: NaN
is: P82251

metaM acald c
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15343
is: HMDB00990
name: acetaldehyde

metaM 3mlda e
is: C05828
type: Species
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
has only substance units: false
is: SBO:0000247
name: 3-Methylimidazoleacetic acid
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/8122
is: HMDB02820
initial concentration: 1.0
constant: false

metaR FACOAL245 1
reactant: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110015#
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false

metaM Rtotal2coa c
boundary condition: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: CHEBI:57876
name: R total 2 coenzyme A
has only substance units: false
initial concentration: 1.0
is: HMDB01564
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaM pppg9 m
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
initial concentration: 1.0
is: CHEBI:57307
constant: false
is: HMDB01097
is: C01079
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: Protoporphyrinogen IX
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_0266a333_246c_480c_838b_5271d25ae9d8
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: O60503
has only substance units: false
name: ADCY9
is encoded by: hsa:115

metaR DHORD9
name: dihydoorotic acid dehydrogenase (quinone10)
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.5.2
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
reversible: false
fast: false
modifier: MODEL1310110015#

metaR RE3050R
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: RE3050
reactant: MODEL1310110015#

metaR FAOXC2442246x
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
name: Beta oxidation of long chain fatty acid
reversible: false
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_338fce13_fc19_4dc9_8c00_1e971e4f31ef
name: ACSL5
is encoded by: hsa:51703
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9ULC5

metaM tymsf c
boundary condition: false
has only substance units: false
is: HMDB06409
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2ded612b_4dcc_4ed3_9cad_ce09944702fd
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: MTHFD1
type: Species
is encoded by: hsa:4522
is: SBO:0000252
constant: false
is: P11586

metaM udpg r
constant: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
initial amount: NaN
is: CHEBI:58367
has only substance units: false
is: HMDB00286
type: Species
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaM HC02180 c
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
initial concentration: 1.0
constant: false
is: CHEBI:28728
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

metaR ASCBt
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_ebf44062_991d_4274_94f9_157d6d691c86
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:953
constant: false
initial concentration: NaN
is: Q86VV3
is: SBO:0000252
name: ENTPD1

metaR r1599
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaM ksi deg41 l
is: CHEBI:12936
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 41
has only substance units: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial concentration: 1.0
constant: false
is: HMDB00143
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_f70382ff_274a_42c8_88f3_ba29c2f0c170
is encoded by: hsa:2618
constant: false
boundary condition: true
is: Q59HH3
name: GART
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR MALSO4tm
product: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
is described by: ECO:0000269
name: Malate:sulfate antiport, mitochondrial

metaM duri c
name: Deoxyuridine
is: CHEBI:16450
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: HMDB00012

metaM dhap c
name: Dihydroxyacetone phosphate
constant: false
boundary condition: false
has only substance units: false
is: HMDB01473
initial concentration: 1.0
is: CHEBI:57642
is: SBO:0000247
type: Species
is: C00111
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN

metaM CE5160 r
constant: false
initial concentration: 1.0
is: HMDB01509
initial amount: NaN
is: CHEBI:57460
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cb3b93d7_507d_4825_8914_8cbe887169d8
has only substance units: false
boundary condition: true
name: CDIPT
constant: false
initial amount: NaN
is: O14735
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:10423

metaM udpacgal g
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
has only substance units: false
boundary condition: false
is: HMDB00304
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

metaM hdca c
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
type: Species
is: HMDB00220
boundary condition: false
initial concentration: 1.0
is: CHEBI:7896
name: palmitate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8cacaa16_eaff_4ad4_9589_1349c8c4d32d
is: Q9H2X9
is encoded by: hsa:57468
name: SLC12A5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM CE2053 r
is: CHEBI:57460
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1/C20H30O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,17-19,22-23H,1-2,6,10-12,15-16H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: CE2053
is: HMDB01509
is: SBO:0000247
name: 20-oxo-leukotriene B4
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2a389881_3cb6_4ce2_abf5_db23b2f2d4be
initial amount: NaN
is encoded by: hsa:5295
initial concentration: NaN
name: PIK3R1
is: SBO:0000252
has only substance units: false
is: E7EX19
type: Species
boundary condition: true
constant: false

metaM tag hs e
initial concentration: 1.0
is: CHEBI:17855
initial amount: NaN
constant: false
type: Species
name: triglyceride
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false

metaM cholcoa x
is: HMDB01374
boundary condition: false
type: Species
name: choloyl-CoA(4-)
is: CHEBI:57373
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0

metaM dgtp e
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: dGTP
is: CHEBI:16497
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440

metaR FAOXC18480m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid

metaM so4 c
constant: false
initial amount: NaN
is: HMDB01448
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
product: MODEL1310110015#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185
name: transport of cholesterol into the cytosol
reactant: MODEL1310110015#
fast: false

metaM HC02180 e
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:28728
name: thromboxane-b2
is: SBO:0000247
type: Species

metaM C02470 c
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: C02470
name: Xanthurenic acid
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00881
is: http://identifiers.org/pubchem.compound/5485

http://identifiers.org/biomodels.db/MODEL1310110015#_c7adc3c8_c663_47c2_b0d9_6d14fda17c15
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57835
has only substance units: false
initial amount: NaN
type: Species
name: SLC4A5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3f384458_f7f9_40c2_9b6c_d880cb3af223
is encoded by: hsa:30833
initial concentration: NaN
type: Species
name: NT5C
is: Q8TCD5
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR KYNAKGAT
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
kinetic law: MODEL1310110015#
name: L-Kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
fast: false

metaR FAOXC241C221x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaM duri e
name: Deoxyuridine
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: C00526
is: HMDB00012
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaR SPODM
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is: SBO:0000176
modifier: MODEL1310110015#
name: superoxide dismutase
is described by: ECO:0000269
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
fast: false
type: Reaction

metaR NRPPHRSFt
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
product: MODEL1310110015#
reversible: false
is: SBO:0000185
reactant: MODEL1310110015#
fast: false
name: norepinephrine sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110015#_bc3f4a45_e5c9_44d7_9a93_4e9300c891ed
type: Species
name: _J03866_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:J03866
boundary condition: true

metaR DESAT22 2p
reversible: false
reactant: MODEL1310110015#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9d50eb43_e798_4a6f_9a64_1a0315029e68
constant: false
initial amount: NaN
is encoded by: hsa:7296
is: SBO:0000252
has only substance units: false
name: TXNRD1
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_a3c93dbc_2adb_4132_967b_7098095fbd17
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: PTEN
is encoded by: hsa:5728
boundary condition: true
is: F6KD01

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
initial amount: NaN
is: SBO:0000247
is: CHEBI:58272
initial concentration: 1.0
constant: false

metaM abt c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:18403
is: HMDB01851
constant: false
type: Species
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol

http://identifiers.org/biomodels.db/MODEL1310110015#_76cc4f47_6ea0_4a66_a1ff_6febd61d302f
type: Species
is: Q96QE2
is encoded by: hsa:114134
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC2A13

metaM amet c
is: HMDB01185
is: CHEBI:15414
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
has only substance units: false
name: S-Adenosyl-L-methionine
is: C00019
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM udpacgal c
constant: false
is: SBO:0000247
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: CHEBI:57847
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaM dcsptn1coa x
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
is: C16173
type: Species
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR r2364
kinetic law: MODEL1310110015#
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_161b3f7d_df27_48a5_bbd3_fa1db551269e
name: APRT
is encoded by: hsa:353
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: P07741
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_030cdfb6_009d_499c_9a6a_b9e1d609152f
is: Q5JZF5
is encoded by: hsa:212
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ALAS2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_2dc16f20_4157_4598_8ff1_dba250de36d5
type: Species
is: Q9NTN3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23169
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: SLC35D1

metaR GASNASE3ly
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
modifier: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176

metaM lac L x
constant: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: (S)-lactate
is: HMDB00190
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b602560d_8261_4e67_9661_a63c6df6adc9
is encoded by: hsa:6487
constant: false
initial amount: NaN
is: Q5T4Y1
initial concentration: NaN
name: ST3GAL3
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM gchola e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
name: glycocholate
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0
is: HMDB00138
initial amount: NaN

metaM dmnoncoa c
name: 4,8 dimethylnonanoyl-CoA
type: Species
initial concentration: 1.0
is: HMDB11604
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

metaR ACITL
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.3.8
name: ATP-Citrate lyase
fast: false
is: SBO:0000176
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
type: Reaction

metaM HC01401 x
is: SBO:0000247
boundary condition: false
is: CHEBI:27668
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR P4508B13r
is: SBO:0000176
fast: false
name: sterol 12-alpha-hydroxylase (nadh)
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110015#
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.95

http://identifiers.org/biomodels.db/MODEL1310110015#_bcdb3413_dd9f_42f3_84b3_5709107a8ae9
is: P40879
name: SLC26A3
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:1811

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM sl L c
type: Species
name: (S)-3-sulfonatolactate(2-)
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:61289
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM ksi deg38 l
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 38
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR PVD3
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
reversible: true
is described by: ECO:0000134
product: MODEL1310110015#
name: Previtamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
reactant: MODEL1310110015#

metaR INSTt4
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: inositol transport via sodium symport
modifier: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction

metaR 5AOPtm
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: true
fast: false
product: MODEL1310110015#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
is: SBO:0000185
name: 5-Aminolevulinate mitochondrial transport

metaR r2363
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: Organic anion transporter 5 Utilized transport

metaM ksi deg5 l
is: HMDB00143
name: keratan sulfate I, degradation product 5
is: CHEBI:12936
constant: false
initial concentration: 1.0
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaM 4abut c
has only substance units: false
is: HMDB00112
boundary condition: false
constant: false
is: C00334
is: CHEBI:3628
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
name: 4-Aminobutanoate
initial concentration: 1.0
type: Species

metaR PCHOLP hs
product: MODEL1310110015#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
name: choline phosphatase
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

metaR 5ADTSTSTERONEtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110015#
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
kinetic law: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_2ed0f225_e8db_43a1_aeaa_f9d975f754e8
is encoded by: hsa:3939
initial concentration: NaN
name: LDHA
is: SBO:0000252
type: Species
is: P00338
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaM tymsf e
is: HMDB06409
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate

http://identifiers.org/biomodels.db/MODEL1310110015#_46bf2261_5ed0_4225_8b2e_2c5216287581
is: P13196
is encoded by: hsa:211
constant: false
name: ALAS1
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR LINKDEG1ly
reversible: false
fast: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110015#

metaM doco13ecoa c
name: 13-docosenoylcoa
has only substance units: false
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791

http://identifiers.org/biomodels.db/MODEL1310110015#_7b08bc1e_5118_4bee_a5ed_2d79b5ab5f85
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9187
is: B4DUG1
has only substance units: false
initial amount: NaN
name: SLC24A1
constant: false
boundary condition: true

metaR r2362
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#

metaR CSNAT2x
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110015#
type: Reaction
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#

metaM L2aadp6sa c
initial concentration: 1.0
is: CHEBI:17917
is: HMDB01263
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
boundary condition: false
has only substance units: false
name: L-allysine
initial amount: NaN
constant: false
is: SBO:0000247

metaR RE1534M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
name: RE1534
reversible: true
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM hx2coa m
is: C00888
name: trans-Hex-2-enoyl-CoA
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB13037
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaM 1p3h5c m
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
has only substance units: false
initial amount: NaN
is: HMDB01369
boundary condition: false
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_36f52471_79db_4f70_969d_0645076ef966
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: PRDX3
is: P30048
is encoded by: hsa:10935
has only substance units: false

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_ef8147a3_b361_40bb_ab27_628f894e7c77
has only substance units: false
initial amount: NaN
name: LDHD
type: Species
boundary condition: true
constant: false
is encoded by: hsa:197257
is: SBO:0000252
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM gchola c
is: HMDB00138
is: CHEBI:58235
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: glycocholate
type: Species
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921

metaR DNDPt23m
is: SBO:0000185
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000269
product: MODEL1310110015#
name: dTDP transport via dGTP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d89aad61_2890_464a_a3c6_d3e74b54a798
constant: false
name: GGT5
initial concentration: NaN
is: P36269
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2687
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_9d1714d3_2c53_4306_9502_b9b922212105
constant: false
has only substance units: false
is encoded by: hsa:137964
type: Species
initial amount: NaN
is: Q86UL3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: AGPAT6

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_41dc30a5_2555_4ecf_ad82_5c2b0b5322a1
is encoded by: hsa:23439
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: P50993
type: Species
constant: false
name: ATP1B4:ATP1A2
initial amount: NaN
is encoded by: hsa:477
has part: Q9UN42
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110015#_c13b5d89_c797_490e_b344_574a57fa70ff
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ABP1
is: P19801
constant: false
is encoded by: hsa:26
has only substance units: false
type: Species

metaR r2361
product: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110015#

metaR G14T3g
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110015#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000

metaM hs deg7 l
is: SBO:0000247
has only substance units: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: HMDB06210
name: heparan sulfate, degradation product 7
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaM tddedi2coa m
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00792
is: C08277
type: Species
name: trans2,6dodecadienoylcoa
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247

metaM crn e
initial concentration: 1.0
is: C00318
is: SBO:0000247
is: HMDB00062
name: L-Carnitine
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
type: Species

metaR CYTK10n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110015#
name: cytidylate kinase (CMP,dGTP),nuclear
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
fast: false

metaR r1052
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#

metaR r2368
reactant: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_930f8ec5_a865_46f4_baf4_3463361c75b5
type: Species
is encoded by: hsa:9152
name: SLC6A5
is: SBO:0000252
constant: false
is: Q9Y345
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_af803d38_e5dc_4e13_b8a9_3e6f021e74b7
name: GPAA1
initial concentration: NaN
is encoded by: hsa:8733
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O43292
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c464f471_d3ec_4a1b_a7ef_528425cdda8e
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:204
type: Species
initial concentration: NaN
initial amount: NaN
name: AK2

metaR PPPGOm
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000304
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.3.4
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
name: protoporphyrinogen oxidase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110015#_56166e3c_fb3c_40fd_b6d7_796b9401d832
name: NDUFS2
is encoded by: hsa:4720
boundary condition: true
has only substance units: false
constant: false
is: B7Z792
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM 4abut e
initial concentration: 1.0
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: HMDB00112
type: Species
name: 4-Aminobutanoate
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:3628

http://identifiers.org/biomodels.db/MODEL1310110015#_3e09865f_57ec_41cb_8b04_4c23665d14da
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: IDH2
boundary condition: true
is encoded by: hsa:3418
type: Species
is: P48735
has only substance units: false

metaR r2367
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM 25aics c
is: HMDB00797
is: C04823
type: Species
initial concentration: 1.0
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58443
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247

metaM dolp L c
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57683
has only substance units: false
name: dolichyl phosphate(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaM gacpail hs c
boundary condition: false
is: CHEBI:16344
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
type: Species
name: glucosaminyl-acylphosphatidylinositol
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00128

metaM 34dhphe c
constant: false
is: SBO:0000247
is: CHEBI:15765
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00181
name: L-dopa
initial amount: NaN
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

metaR M13N4Tg
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11320.1) or (11282.2) or (11282.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.145 Confidence Level: 0 AUTHORS: PMID:10024668,PMID:10372966 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.145

metaM btn c
name: Biotin
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: C00120
is: CHEBI:3420
is: HMDB00030
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3df95454_dd3e_443b_ab46_6309e1a97a3c
boundary condition: true
has only substance units: false
is encoded by: hsa:6484
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q6IBE6
constant: false
name: ST3GAL4

metaR S3TASE3ly
reversible: true
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110015#_a0a2cace_e58e_4bf5_88a0_44476b789785
constant: false
name: DEGS1
initial amount: NaN
is encoded by: hsa:8560
is: SBO:0000252
has only substance units: false
is: O15121
boundary condition: true
type: Species
initial concentration: NaN

metaM crn c
initial concentration: 1.0
is: C00318
has only substance units: false
name: L-Carnitine
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16347
constant: false
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM pppg9 c
name: Protoporphyrinogen IX
initial concentration: 1.0
is: C01079
is: HMDB01097
initial amount: NaN
is: SBO:0000247
is: CHEBI:57307
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
constant: false

metaR r1050
fast: false
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
name: Vesicular transport

metaM Lcyst c
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58090
is: HMDB02757
has only substance units: false
boundary condition: false
name: L-cysteate(1-)
initial concentration: 1.0
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
type: Species

metaM ksi pre8 g
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 8

metaM 34dhphe e
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
initial concentration: 1.0
name: L-dopa
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00181
type: Species
is: CHEBI:15765
is: SBO:0000247
boundary condition: false

metaR BACCL
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_cd9011da_271c_4afd_99f9_77400d90f801
name: AMPD2
has only substance units: false
is: E9PNG0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:271
constant: false
boundary condition: true
type: Species

metaM HC01603 c
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00234

metaR RE2079R
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
name: RE2079
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110015#
fast: false

metaR r2366
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM HC02208 c
is: SBO:0000247
boundary condition: false
name: prostaglandin-d1
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:27696
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_19337d26_0c8c_4eb1_bf3a_5fde9f9ce35e
name: DHFR
is: SBO:0000252
is: P00374
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1719
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b1f8c718_0045_483c_a911_5a4cb7ee1dce
initial concentration: NaN
is encoded by: hsa:BG035985
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _BG035985_1_c
type: Species
constant: false
has only substance units: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR SLDt
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
reversible: false
is: SBO:0000185
name: L-sulfolactate transport (cytosol to extracellular)
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR HACD9m
reversible: true
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial

metaR 5ADTSTSTERONEte
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110015#
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_dc1d1b72_7fb7_4a60_be54_a074be3abbac
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AA788780_1_c
has only substance units: false
is encoded by: hsa:AA788780

http://identifiers.org/biomodels.db/MODEL1310110015#_85700e35_79c4_4719_a7a8_fcd708a08d42
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5833
name: PCYT2
initial amount: NaN
is: F5H8B1
is: SBO:0000252
boundary condition: true

metaM duri n
initial amount: NaN
type: Species
is: CHEBI:16450
name: 2'-deoxyuridine
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
is: HMDB00012
initial concentration: 1.0

metaR M13N2Tg
is version of: http://identifiers.org/ec-code/2.4.1.101
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
product: MODEL1310110015#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110015#

metaM lgt S c
initial concentration: 1.0
type: Species
is: CHEBI:57474
is: HMDB01066
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
boundary condition: false
has only substance units: false
name: (R)-S-lactoylglutathionate(1-)
constant: false

metaR r1051
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
type: Reaction
reversible: true

metaM CE1935 e
is: SBO:0000247
is: HMDB02329
name: spermine monoaldehyde
initial concentration: 1.0
is: CHEBI:30623
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
type: Species

metaR r2365
reactant: MODEL1310110015#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_08b71cf4_dca2_4cfe_8d8d_4d412fd06c02
is encoded by: hsa:341947
is encoded by: hsa:1327
is encoded by: hsa:1339
is encoded by: hsa:4514
has part: Q8TF08
has part: P13073
has part: P12074
type: Species
is encoded by: hsa:1340
has part: Q02221
boundary condition: true
has part: Q6FGA0
has part: P24311
is encoded by: hsa:1347
has part: P20674
is encoded by: hsa:125965
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P24310
is encoded by: hsa:1345
has part: Q7GXZ8
is encoded by: hsa:1329
is encoded by: hsa:9377
constant: false
is encoded by: hsa:84701
has part: Q53XN1
has part: Q7Z4L0
has part: Q53YB7
is encoded by: hsa:9167
is: SBO:0000297
has only substance units: false
is encoded by: hsa:1349
has part: P00414
is encoded by: hsa:1350
has part: Q96KJ9
has part: Q6YFQ2
is encoded by: hsa:1337
is encoded by: hsa:1346
initial concentration: NaN
is encoded by: hsa:4513
has part: P09669
is encoded by: hsa:170712
has part: Q7GXY8
is encoded by: hsa:4512
initial amount: NaN
has part: P15954
is encoded by: hsa:1351
has part: H0UI06
has part: P14854

metaR RE3624M
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reactant: MODEL1310110015#
name: RE3624
type: Reaction
reversible: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaR CYTK8n
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP,dATP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110015#_c5a3090c_230e_4bc1_abdf_6395622440a3
initial amount: NaN
has only substance units: false
name: COX3
is: P00414
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4514
type: Species

metaM c226crn c
initial amount: NaN
boundary condition: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
initial concentration: 1.0
name: cervonyl carnitine
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/127055
is: HMDB06510
has only substance units: false

metaR PI45PLC
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_6c9c7144_f370_41a9_9b40_085f54a98fff
initial amount: NaN
is: Q16851
type: Species
name: UGP2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:7360

metaM dgtp c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: C00286
is: HMDB01440
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
constant: false
initial amount: NaN

metaM so4 e
boundary condition: false
name: sulfate
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
constant: false
initial amount: NaN
is: CHEBI:16189
is: SBO:0000247

metaM btn e
is: C00120
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: Biotin
is: SBO:0000247
boundary condition: false
is: CHEBI:3420
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110015#_3c4b30ec_06b9_4b4c_9403_2e68040c4bd0
name: PDE8A
initial amount: NaN
constant: false
is encoded by: hsa:5151
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: O60658
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_f2f368ec_5759_4fa4_8a8f_00b268af6474
constant: false
is: Q13946
has only substance units: false
name: PDE7A
is encoded by: hsa:5150
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_777a4bf3_2d18_428c_a95e_66ceea49e400
has only substance units: false
is: P56385
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:521
constant: false
name: ATP5I

metaM HC02208 e
is: CHEBI:27696
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
boundary condition: false
initial amount: NaN

metaM acgam6p c
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57513
type: Species
is: HMDB01062
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
name: N-acetyl-D-glucosamine 6-phosphate(2-)

metaM tag hs c
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17855
name: triglyceride
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0

metaR CSAPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110015#
fast: false
reversible: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#

metaM but c
type: Species
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
boundary condition: false
initial amount: NaN
name: butyrate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17968
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2f18d7a5_b8e4_42ac_a405_8d07f0effb15
initial amount: NaN
is: P31040
boundary condition: true
is: SBO:0000252
name: SDHA
initial concentration: NaN
is encoded by: hsa:6389
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_f23d2c35_18e1_4775_bd7c_d30ac49309d0
name: ALDH1B1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P30837
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:219

metaR RE0577C
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0577
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_4b868e71_7335_4d99_8840_beb9033c412f
has only substance units: false
is encoded by: hsa:6785
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9GZR5
name: ELOVL4
initial concentration: NaN
constant: false

metaR LINKDEG4ly
product: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
fast: false
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110015#

metaR PGI
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is described by: ECO:0000134
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.9
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
product: MODEL1310110015#
is: SBO:0000176
name: glucose-6-phosphate isomerase

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR PROSTGD2t
is: SBO:0000185
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
product: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR NACHEX13ly
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110015#

metaM 6pgc r
is: CHEBI:58759
boundary condition: false
is: HMDB01316
has only substance units: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
type: Species
initial concentration: 1.0
name: 6-phosphonatooxy-D-gluconate
constant: false
initial amount: NaN
is: SBO:0000247

metaR ADK3m
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
name: adentylate kinase (GTP)
is described by: ECO:0000269
modifier: MODEL1310110015#
is: SBO:0000176
fast: false

metaM 1p3h5c c
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
is: HMDB01369
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
constant: false
initial amount: NaN
has only substance units: false

metaR G6Pter
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
kinetic law: MODEL1310110015#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_f960bb5c_6d60_4c79_8df6_8010375a4569
is: O43252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:9061
is: SBO:0000252
initial concentration: NaN
name: PAPSS1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_003e80a9_8cbb_43d2_b418_019cb5fcf003
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
type: Species
boundary condition: true
is: Q8TE04
initial amount: NaN

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM ala B m
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00056
is: CHEBI:16958
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_fccd8363_1fcb_44b7_a20b_4d437f8a119a
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5140
is: A7E2E5
name: PDE3B
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8f7900a1_c1e7_4322_8af7_f00bc09829ff
is: O75251
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:374291
name: NDUFS7

metaR S6T10g
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction

metaR r1167
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110015#
name: EC:2.3.1.26
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110015#

metaR ALAGLNexR
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110015#
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110015#

metaM CE5120 m
has only substance units: false
is: CHEBI:57923
type: Species
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_cfa70f4c_7c7a_4789_8b25_ffecee973229
initial concentration: NaN
is: SBO:0000252
name: SLC4A5
is encoded by: hsa:57835
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR SLDx
is: SBO:0000176
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
fast: false
name: L-sulfolactate dehydrogenase (NAD+)
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR DAGKn hs
reversible: true
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: Diacylglycerol phosphate kinase (homo sapiens)
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
kinetic law: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a36d4645_0b8c_415e_8f63_929092435530
is: SBO:0000252
name: LSS
initial amount: NaN
has only substance units: false
is encoded by: hsa:4047
boundary condition: true
type: Species
is: E9PEI9
initial concentration: NaN
constant: false

metaM hdca e
has only substance units: false
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: CHEBI:0
boundary condition: false
type: Species
initial amount: NaN
is: C00249
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
is: HMDB00220

metaR r2369
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
fast: false

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
type: Species
initial amount: NaN
is: CHEBI:57642
is: HMDB01473
is: SBO:0000247
name: glycerone phosphate(2-)
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR PGK
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.2.3
is: SBO:0000176
reversible: true
product: MODEL1310110015#
name: phosphoglycerate kinase
is described by: ECO:0000134

metaM but e
initial amount: NaN
constant: false
type: Species
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
is: HMDB00039
has only substance units: false
name: butyrate
is: SBO:0000247
boundary condition: false

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
is: HMDB03571
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: C01832
initial amount: NaN
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110015#_1591729e_768c_4003_a6a7_aa1e902f4a76
initial concentration: NaN
name: CDIPT
constant: false
boundary condition: true
type: Species
is: A8K3L7
is encoded by: hsa:10423
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR ACGAMK
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.59
modifier: MODEL1310110015#
fast: false
name: N-acetylglucosamine kinase

http://identifiers.org/biomodels.db/MODEL1310110015#_e0981467_f865_44b9_857c_3adb5239c3be
is: Q9NVF9
name: ETNK2
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55224
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_af94d4c8_9acd_4d07_baf2_d9c8ae4a086b
type: Species
name: HSD17B4
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: E9PB82
boundary condition: true
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110015#_7fb61d42_4fa5_4dcf_a901_96272805ca0a
name: HAGH
boundary condition: true
has only substance units: false
is encoded by: hsa:3029
type: Species
is: SBO:0000252
is: Q16775
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_ad1b5e04_eb74_48ee_98b3_11b4bc46733b
name: HPRT1
is: P00492
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3251
constant: false
initial amount: NaN
has only substance units: false

metaR BAMPPALDOX
type: Reaction
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is described by: ECO:0000212
is: SBO:0000176
reactant: MODEL1310110015#
fast: false

metaM 4abut n
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 4-Aminobutanoate
is: HMDB00112
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
is: C00334

http://identifiers.org/biomodels.db/MODEL1310110015#_24d4e630_66ef_4255_861c_b84a2c7bb090
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: MANBA
is: O00462
is: SBO:0000252
is encoded by: hsa:4126
has only substance units: false
type: Species

metaR r2517
reactant: MODEL1310110015#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110015#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is described by: ECO:0000000

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
product: MODEL1310110015#
is described by: ECO:0000000
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
is: CHEBI:58432
is: SBO:0000247
type: Species
name: histamium
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_dc97ce68_480e_4d28_bae3_9dc66cd47329
is: SBO:0000252
constant: false
is encoded by: hsa:2517
initial amount: NaN
is: P04066
name: FUCA1
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM itaccoa m
is: CHEBI:57381
constant: false
is: HMDB03377
name: itaconyl-CoA(5-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
has only substance units: false

metaM dtdp e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58369
is: HMDB01274
constant: false
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0

metaR ME1m
fast: false
product: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
name: malic enzyme (NAD), mitochondrial
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_b2226bbd_7fcb_4380_80df_604ee3ab1eb6
boundary condition: true
is: Q8NCL4
initial amount: NaN
type: Species
is encoded by: hsa:11226
has only substance units: false
constant: false
name: GALNT6
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_224f1460_7777_435e_8525_d98127814eb2
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:249
initial concentration: NaN
name: ALPL
has only substance units: false
is: B7Z4Y6

metaM 2docohexecoa m
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
constant: false
type: Species
name: 2,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_68c07cc7_df64_46d5_b0d7_075177e45d14
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: G3XAJ0
name: ACAD10
boundary condition: true
has only substance units: false
is encoded by: hsa:80724
initial concentration: NaN

metaM hdca r
constant: false
name: Hexadecanoate (n-C16:0)
boundary condition: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
initial concentration: 1.0
initial amount: NaN
is: HMDB00220
is: SBO:0000247
is: C00249
type: Species

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species
name: 4-Aminobutanoate
is: HMDB00112
has only substance units: false
boundary condition: false
is: C00334
is: SBO:0000247
constant: false
is: CHEBI:16865
initial amount: NaN
initial concentration: 1.0

metaR EICOSTETt
product: MODEL1310110015#
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:28111
boundary condition: false
type: Species
is: HMDB05175
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

metaM dmnoncoa x
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 4,8 dimethylnonanoyl-CoA
constant: false
type: Species
is: HMDB11604

metaR SIAT4Bg
is: SBO:0000176
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110015#

metaR RE3241R
product: MODEL1310110015#
name: RE3241
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR r2518
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

metaR SO4t4 2
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
kinetic law: MODEL1310110015#
fast: false
name: sulfate transport via sodium symport

metaM 3hexdtricoa m
type: Species
is: HMDB02288
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
name: 3,7,10-hexadecatrienoylcoa

metaR r1873
product: MODEL1310110015#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaM cs e l
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:36005
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
boundary condition: false
is: HMDB02183
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7e5b44b3_7046_4141_b586_978d85cf920b
is: SBO:0000252
is encoded by: hsa:8706
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: Q8TDY1
boundary condition: true
type: Species
name: B3GALNT1

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM dd2coa m
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
type: Species
initial concentration: 1.0
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712
has only substance units: false

metaM HC01401 m
type: Species
is: CHEBI:27668
is: SBO:0000247
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

http://identifiers.org/biomodels.db/MODEL1310110015#_8099301e_a949_4f0e_aa1f_b630b5b3b3be
constant: false
initial amount: NaN
is: Q6FHI7
initial concentration: NaN
name: CA4
type: Species
is: SBO:0000252
is encoded by: hsa:762
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_947b773b_00c9_4133_8393_26d805a33645
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: B7Z763
is: SBO:0000252
name: AMPD3
type: Species
is encoded by: hsa:272
initial amount: NaN

metaM hista e
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
is: CHEBI:58432
initial amount: NaN
type: Species
name: histamium
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00870

http://identifiers.org/biomodels.db/MODEL1310110015#_d3b9da2c_4ebc_47f8_b763_1e6cc8330f25
boundary condition: true
constant: false
is encoded by: hsa:513
has only substance units: false
type: Species
name: ATP5D
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM ps hs c
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: ps_hs[c]
is: CHEBI:18303
is: SBO:0000247

metaR XOLDIOLONEt
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110015#
name: lipid, flip-flop intracellular transport
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
reversible: true

metaR S26Tg
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: beta-galactoside alpha-2,6-sialyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.1
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176

metaR r2516
fast: false
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
product: MODEL1310110015#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_a980e451_919c_4235_9f50_48b5ea9ae59c
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: CAD
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:790
is: P27708
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_0ed489f2_e34f_4fce_8356_e45e851fbe4d
type: Species
is: B8ZZR8
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:79017
name: GGCT
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_3c18f96c_6d81_48b4_81d6_1e1710ce5db0
type: Species
is encoded by: hsa:LOC727762
boundary condition: true
constant: false
initial concentration: NaN
name: _LOC727762_1_m
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR FAOXC226m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR GCC2cm
reversible: true
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110015#_dc1e1c96_dbe4_460f_b557_7813550ce85d
initial concentration: NaN
name: NDUFC2
boundary condition: true
is encoded by: hsa:4718
has only substance units: false
is: Q549M5
is: SBO:0000252
initial amount: NaN
constant: false
type: Species

metaM 4abutn m
name: 4-ammoniobutanal
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01080
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

http://identifiers.org/biomodels.db/MODEL1310110015#_718e7d0f_98cb_4b11_bd1c_b152c54e1137
initial concentration: NaN
boundary condition: true
name: GPX1
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2876
type: Species

metaM amet m
type: Species
boundary condition: false
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
is: HMDB01185
is: SBO:0000247
is: C00019
initial amount: NaN
name: S-Adenosyl-L-methionine
has only substance units: false
initial concentration: 1.0

metaM HC02216 c
type: Species
is: CHEBI:28922
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin-f2beta
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d9a97388_88bb_4a0d_b63a_ea45d950b6ae
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: P28330
has only substance units: false
type: Species
is: SBO:0000252
name: ACADL
is encoded by: hsa:33

http://identifiers.org/biomodels.db/MODEL1310110015#_3eb2b0ac_71c2_4bca_97fb_415d490426d2
is encoded by: hsa:52
initial concentration: NaN
name: ACP1
is: Q59EH3
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR r0603
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110015#
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000176

metaR PPItx
reactant: MODEL1310110015#
type: Reaction
name: Diphosphate transporter, peroxisome
reversible: true
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#

metaM arachdcrn m
constant: false
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01322
name: C20:4 carnitine
has only substance units: false
initial concentration: 1.0
is: CHEBI:57387

metaM Lkynr c
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
name: L-kynurenine
is: CHEBI:16946
initial amount: NaN
is: SBO:0000247
is: HMDB00684

metaM so4 l
is: HMDB01448
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: sulfate
type: Species
is: CHEBI:16189
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false

metaR CORE4GTg
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000176

metaM c226coa x
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
name: cervonyl coenzyme A
initial amount: NaN
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_cbc64b8b_4fed_4aa6_9ec4_50aea4cc34d8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2108
has only substance units: false
boundary condition: true
is encoded by: hsa:2109
type: Species
constant: false
is: SBO:0000297
has part: P13804
name: ETFA:ETFB

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: CHEBI:18107
constant: false
name: xanthosine
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00299
initial concentration: 1.0

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_0996583e_3b63_4a6f_910c_fbb41ac7646e
is: SBO:0000252
has only substance units: false
type: Species
name: _AA177072_1_x
is encoded by: hsa:AA177072
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM so4 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: CHEBI:16189

metaM btn m
is: CHEBI:57586
type: Species
name: biotinate
constant: false
is: SBO:0000247
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM kynate c
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58454
is: HMDB00715
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
constant: false
boundary condition: false
name: kynurenate

http://identifiers.org/biomodels.db/MODEL1310110015#_88bd75c3_310d_4b75_aedb_9913e4f76c25
is: SBO:0000252
has only substance units: false
name: PDE1A
constant: false
initial amount: NaN
is encoded by: hsa:5136
is: P54750
type: Species
boundary condition: true
initial concentration: NaN

metaM mi34p c
type: Species
is: HMDB06235
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
name: 1D-myo-Inositol 3,4-bisphosphate
initial amount: NaN
is: CHEBI:28858
boundary condition: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM ametam c
is: CHEBI:57443
is: HMDB00988
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: S-Adenosylmethioninamine
initial amount: NaN
is: C01137
constant: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9a1be5e3_cf49_4df3_9ac0_ce0184feddc6
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q92959
type: Species
name: SLCO2A1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6578
constant: false

metaM HC02216 e
type: Species
is: CHEBI:28922
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin-f2beta

metaR GALSIDEtl
reversible: true
name: galactocerebroside intracellular transport
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
product: MODEL1310110015#

metaM btn n
is: SBO:0000247
is: CHEBI:57586
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: biotinate
boundary condition: false

metaR GLRASE
reactant: MODEL1310110015#
type: Reaction
reversible: true
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
name: glucuronolactone reductase
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_c7952047_4647_4224_a7a5_bd7f59a91735
is encoded by: hsa:349565
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q96T66
name: NMNAT3
type: Species
has only substance units: false
initial amount: NaN

metaM xol7aone c
is: SBO:0000247
initial amount: NaN
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
is: HMDB01993
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0

metaR r2519
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Utilized transport
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaR TYMSFt
fast: false
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate

metaR NaKt
modifier: MODEL1310110015#
is described by: ECO:0000269
name: Na+/K+ exchanging ATPase
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
fast: false
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.6.3.9

metaM n3m2masn g
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C05881
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)3-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN

metaM hdca l
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:7896
has only substance units: false
name: palmitate
is: HMDB00220

metaR ADAe
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
fast: false
name: Adenosine deaminase, extracellular
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110015#

metaR ACETONEt2m
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000185
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_10118a47_5b50_4d22_9868_b036d18675a4
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
name: ST3GAL3
has only substance units: false

metaM zymst r
name: zymosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial amount: NaN
is: CHEBI:18252
constant: false
is: HMDB06271
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaM adp x
initial amount: NaN
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
initial concentration: 1.0
is: HMDB01341
is: CHEBI:456216
is: SBO:0000247
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_46fa1863_ba9a_44fc_b3c8_ee03843c6f0e
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110015#_3e35fe2b_2e9f_48ca_ba30_e5d954688604
initial concentration: NaN
is encoded by: hsa:57835
name: SLC4A5
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5dfd8beb_6a9f_4b5e_9632_bc355210f050
name: GAPDH
is: E7EUT4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2597
constant: false
boundary condition: true
initial amount: NaN

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#

metaM vacccoa c
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
name: vaccenyl coenzyme A
boundary condition: false
is: http://identifiers.org/pubchem.compound/9543677
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false

metaR METtec
fast: false
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000269
name: L-methionine transport via diffusion (extracellular to cytosol)
type: Reaction

metaM dd2coa x
is: HMDB03712
initial concentration: 1.0
is: CHEBI:57330
has only substance units: false
name: trans-Dodec-2-enoyl-CoA
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

metaR N4Tg
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176

metaM ddcacoa m
boundary condition: false
constant: false
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
is: CHEBI:57375
is: C01832
initial concentration: 1.0
is: HMDB03571
is: SBO:0000247
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)

metaR AG13T6g
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#

metaR r0752
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
kinetic law: MODEL1310110015#
reversible: true
fast: false
product: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000

metaR r1384
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110015#
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
fast: false

metaR PNTOte
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
name: Transport of (R)-Pantothenate
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110015#_4f3dab13_4f65_4359_9f05_7afb7b3f751c
initial amount: NaN
boundary condition: true
is encoded by: hsa:9334
name: B4GALT5
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: O43286
has only substance units: false

metaR HSPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110015#
reversible: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
name: heparan sulfate proteoglycan protease, lysosome (endosome)
fast: false
is described by: ECO:0000000

metaR THMP
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: thiamin phosphatase

metaM taur x
type: Species
boundary condition: false
is: CHEBI:15891
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
has only substance units: false
constant: false
is: HMDB00251
name: taurine
is: SBO:0000247

metaR 3MOPt2im
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_609cff97_1326_4dad_862d_77d8f83b520a
is: SBO:0000297
name: VNN3:VNN2:VNN1
boundary condition: true
has part: O95498
is encoded by: hsa:55350
is encoded by: hsa:8875
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_861aeef4_8948_4471_b8bb_618d8b4eb311
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GSR
has only substance units: false
type: Species
is: SBO:0000252
is: P00390
constant: false
is encoded by: hsa:2936

metaM xol7ah c
boundary condition: false
has only substance units: false
is: CHEBI:2290
is: SBO:0000247
constant: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN
initial concentration: 1.0
is: HMDB06892
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451

metaM ascb L c
initial concentration: 1.0
is: HMDB00044
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
is: SBO:0000247
initial amount: NaN
is: CHEBI:38290
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_1f812da4_7cd1_40fa_abd4_3e0ad09cc1c6
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: _FLJ44968_1_m
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:FLJ44968

metaM l2fn2m2masn g
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C68H113N4O49X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110015#_9175d1dd_8df5_4913_aaf2_4190831738bf
type: Species
is: SBO:0000252
name: ST8SIA1
initial concentration: NaN
is: Q92185
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:6489
constant: false

metaR SFGTH
kinetic law: MODEL1310110015#
name: S-Formylglutathione hydralase
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.2.12
is: SBO:0000176
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false

metaR NACHEX18ly
fast: false
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110015#

metaR FAOXTC182TC162m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM dha e
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
constant: false
is: HMDB01882
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16016
is: SBO:0000247
has only substance units: false
name: glycerone
type: Species

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM cs e deg5 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
is: HMDB00868
is: CHEBI:57737
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4

metaR ACNAMtn
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
name: N-acetylneuraminate nuclear import

metaR RE1519M
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
type: Reaction
name: RE1519
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#

metaM Sfglutth c
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB01550
initial amount: NaN
is: CHEBI:57688
has only substance units: false
name: S-formylglutathionate(1-)
boundary condition: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR FAOXC13C11m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaM gacpail hs r
is: CHEBI:16344
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00128
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4149e616_dcc9_417f_8de4_95691ca5ff25
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:7083
type: Species
initial amount: NaN
is: P04183
is: SBO:0000252
name: TK1
has only substance units: false

metaR DOLMANP Uter
type: Reaction
product: MODEL1310110015#
name: dolichol-phosphate mannose flippase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_26369458_bdb2_4719_8ead_82d6f742771c
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: P30519
type: Species
initial amount: NaN
is encoded by: hsa:3163
name: HMOX2

metaM dca c
has only substance units: false
name: Decanoate (n-C10:0)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1
boundary condition: false
type: Species
is: C14143
is: HMDB04047
constant: false

metaM arachdcrn c
constant: false
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
is: CHEBI:57387
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01322

metaR r0750
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
reversible: true

metaR S3TASE2ly
type: Reaction
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110015#

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reversible: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c4170852_a062_4209_8413_e70e40b71c28
type: Species
boundary condition: true
is encoded by: hsa:4830
has only substance units: false
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
name: NME1:NME2

http://identifiers.org/biomodels.db/MODEL1310110015#_109566d6_4a62_4ec6_8df0_7e7fc4f80fa2
is encoded by: hsa:10400
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: PEMT
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM dopasf c
initial amount: NaN
name: dopamine 3-O-sulfate
initial concentration: 1.0
is: HMDB06275
has only substance units: false
constant: false
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8498f5ce_6628_4ea4_b330_fca3f7fa569c
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:954
is: SBO:0000252
is: Q5SPY7
name: ENTPD2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_a187a337_0633_4c2a_8e55_117eeb5cb8f7
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:7298
initial concentration: NaN
has only substance units: false
is: P04818
boundary condition: true
type: Species
name: TYMS

metaM 5fthf m
name: 5-formyltetrahydrofolate(2-)
constant: false
boundary condition: false
is: CHEBI:57457
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01562
initial concentration: 1.0

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR r1492
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110015#
name: Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR ALOX52
name: Arachidonate 5-lipoxygenase
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110015#

metaM CE1936 e
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: spermine dialdehyde
constant: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
initial amount: NaN
is: CHEBI:36781

http://identifiers.org/biomodels.db/MODEL1310110015#_f04bdde6_03f2_4441_afe0_b2599f660053
is: SBO:0000252
type: Species
is encoded by: hsa:50484
initial amount: NaN
has only substance units: false
name: RRM2B
initial concentration: NaN
is: Q7LG56
constant: false
boundary condition: true

metaR r1381
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#

metaM 4abutn e
constant: false
boundary condition: false
is: HMDB01080
is: SBO:0000247
name: 4-ammoniobutanal
initial amount: NaN
is: CHEBI:58264
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR PHCDm
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
modifier: MODEL1310110015#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
kinetic law: MODEL1310110015#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR PMTCOAtx
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#
name: fatty acid intracellular transport
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction

metaM dhap x
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
is: HMDB01473
initial concentration: 1.0
has only substance units: false
is: C00111
is: CHEBI:57642
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR DESAT20 1
reversible: false
product: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

metaR r1876
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false

metaR r1380
product: MODEL1310110015#
type: Reaction
is: SBO:0000176
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true

metaM cholcoa c
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57373
is: HMDB01374
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
name: choloyl-CoA(4-)

metaM dca e
name: Decanoate (n-C10:0)
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB04047
constant: false
is: C14143
boundary condition: false

metaM ksi pre36 g
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 36
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_eb0cdb61_1b4e_4fe9_92e2_f7594afb5b61
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SULT1A1
has only substance units: false
type: Species
is encoded by: hsa:6817
initial concentration: NaN
constant: false

metaM 34dhoxpeg e
is: C05576
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7902
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
initial concentration: 1.0
type: Species
has only substance units: false
name: 3,4-Dihydroxyphenylethyleneglycol
is: HMDB00318

http://identifiers.org/biomodels.db/MODEL1310110015#_0054c5c2_eaf4_44ee_a73f_e78f55092a1f
type: Species
is: Q9BZV2
name: SLC19A3
is encoded by: hsa:80704
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaM c226crn m
initial amount: NaN
initial concentration: 1.0
name: cervonyl carnitine
is: HMDB06510
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
constant: false
type: Species

metaM gpi sig r
type: Species
is: CHEBI:37568
constant: false
has only substance units: false
is: HMDB01342
is: C00459
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: Y CHARGE: 0
initial amount: NaN
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)

metaM 6pgc c
has only substance units: false
initial amount: NaN
type: Species
name: 6-Phospho-D-gluconate
constant: false
is: CHEBI:58759
boundary condition: false
is: HMDB01316
is: SBO:0000247
notes: FORMULA: C6H10O10P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: C00345
initial concentration: 1.0

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM mev R c
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
initial amount: NaN
is: HMDB00227
is: CHEBI:36464
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: (R)-mevalonate
boundary condition: false

metaR CSPG Etly
is: SBO:0000185
type: Reaction
reversible: false
name: chondroitin sulfate E transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_34da5593_b08f_426e_8bea_02f059e2e1ed
has only substance units: false
type: Species
constant: false
is: Q11203
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6487
name: ST3GAL3

metaM dopasf e
is: CHEBI:37946
initial concentration: 1.0
constant: false
is: HMDB06275
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
has only substance units: false
type: Species
name: dopamine 3-O-sulfate
is: SBO:0000247
initial amount: NaN

metaM HC02202 c
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
initial concentration: 1.0
is: CHEBI:57398

metaM udpacgal l
has only substance units: false
is: HMDB00304
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ab795fba_b60e_4d58_92f7_4669dd58278a
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8883
name: NAE1
is: SBO:0000252
has only substance units: false
is: A8MU28

metaR r2514
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR S6TASE26ly
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR GALASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
name: beta-galactosidase, lysosomal

metaM ksi pre10 g
is: SBO:0000247
is: C00130
is: CHEBI:58053
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
initial amount: NaN
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 10
is: HMDB00175

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
is: CHEBI:58264
initial concentration: 1.0
boundary condition: false
is: C00555
initial amount: NaN
name: 4-Aminobutanal
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaR r0755
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

metaM stcoa c
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00412
is: CHEBI:57394
is: SBO:0000247
is: HMDB01114

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176

metaM dtdp c
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: C00363
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: CHEBI:58369
name: dTDP

http://identifiers.org/biomodels.db/MODEL1310110015#_42c6140c_8d66_435b_b7ba_555ad41b85ad
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4597
is: SBO:0000252
boundary condition: true
name: MVD
initial amount: NaN
type: Species
is: P53602
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1beb8716_8b95_434d_bc10_183ef0a577af
is: O95861
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:10380
has only substance units: false
type: Species
boundary condition: true
name: BPNT1

http://identifiers.org/biomodels.db/MODEL1310110015#_4ad85d46_4dbb_4faa_8b0f_ebb14b679564
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: CA2
has only substance units: false
is: P00918
is encoded by: hsa:760
initial amount: NaN

metaR r2511
name: Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM 34dhoxpeg c
is: HMDB00318
type: Species
name: 3,4-Dihydroxyphenylethyleneglycol
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
boundary condition: false
is: C05576
is: http://identifiers.org/pubchem.compound/7902
has only substance units: false
is: SBO:0000247
constant: false

metaR SUCCt4 2
reversible: true
product: MODEL1310110015#
name: succinate transport via sodium symport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
type: Reaction
is: SBO:0000185
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_081a328c_b8a3_48b5_b9a0_b7ef86fc06b0
is: Q9NUB1
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:84532
name: ACSS1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR r0753
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_3b99f3ff_4dae_4323_bbaf_3b024c7a1020
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: PLCG2
initial amount: NaN
is: P16885
type: Species
is: SBO:0000252
is encoded by: hsa:5336

metaM HC02202 e
is: SBO:0000247
boundary condition: false
has only substance units: false
name: prostaglandin A1(1-)
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
constant: false
is: CHEBI:57398
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_9b334195_94ba_440d_bed0_668717e0bf45
is encoded by: hsa:LOC728997
initial amount: NaN
type: Species
name: _LOC728997_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR FATP2t
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110015#
fast: false
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110015#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR FTHFDH
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.6 Confidence Level: 4 AUTHORS: PMID:2733692 NOTES:IT
is: SBO:0000176
fast: false
name: formyltetrahydrofolate dehydrogenase
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.1.6
is described by: ECO:0000269

metaM ascb L e
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
name: L-ascorbate
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:38290

metaM xol7aone m
is: SBO:0000247
has only substance units: false
is: HMDB01993
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaR DURIPP
product: MODEL1310110015#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
is described by: ECO:0000269
name: deoxyuridine phosphorylase
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaM udpgal c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: UDP-D-galactose(2-)
initial amount: NaN
is: CHEBI:58439
is: HMDB00302
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_68be773d_b6ae_4b83_bf4e_66157a93a656
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10846
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9Y233
name: PDE10A
type: Species

metaM hs deg12 l
has only substance units: false
initial concentration: 1.0
is: HMDB06210
boundary condition: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
name: heparan sulfate, degradation product 12
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaR MM5ag
modifier: MODEL1310110015#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110015#_07049697_3452_4df3_a4b8_bfbb9bb5ef2b
is encoded by: hsa:5095
initial concentration: NaN
constant: false
has part: C9JPQ8
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PCCA:PCCB
has part: P05166
is: SBO:0000297
is encoded by: hsa:5096

metaM acgal1p c
initial amount: NaN
is: HMDB06480
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:55404
name: N-Acetyl-D-galactosamine 1-phosphate
has only substance units: false

metaM xylu D c
has only substance units: false
boundary condition: false
is: CHEBI:17140
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
is: SBO:0000247
constant: false
is: HMDB01644
initial concentration: 1.0
type: Species
name: D-xylulose
initial amount: NaN

metaM ksi deg9 l
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 9
initial amount: NaN
is: HMDB00143
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial concentration: 1.0
is: CHEBI:12936

metaM retinol c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00305
is: CHEBI:50211
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
is: SBO:0000247

metaM adp m
has only substance units: false
constant: false
boundary condition: false
name: ADP
is: SBO:0000247
type: Species
is: C00008
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341
is: CHEBI:456216

metaR ACONTm
is described by: ECO:0000134
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: true
name: Aconitate hydratase

metaR GTMLTe
reversible: false
name: g-glutamyltransferase (e)
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110015#

metaM ksii core2 e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
has only substance units: false
initial amount: NaN
name: keratan sulfate II (core 2-linked)
is: HMDB00211
is: CHEBI:17268
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9c4aad88_1c24_46ce_ae9e_c4735fb5199a
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P19961
type: Species
is: SBO:0000252
name: AMY2B
is encoded by: hsa:280
constant: false

metaM adrnl c
type: Species
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
is: CHEBI:33568
constant: false
is: SBO:0000247
is: HMDB00068
name: Adrenaline
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM adp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
boundary condition: false
constant: false
is: HMDB01341
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: ADP(3-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_360280ac_47c5_4a8d_afe3_535a0e1ba67f
is encoded by: hsa:4122
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9P1E4
initial amount: NaN
name: MAN2A2
constant: false
type: Species
boundary condition: true

metaM m7masnC g
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: CHEBI:58401
has only substance units: false
type: Species
is: HMDB06814
is: SBO:0000247
initial amount: NaN
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)

metaR PI34P5K
product: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol 3,4-bisphosphate 5-kinase

http://identifiers.org/biomodels.db/MODEL1310110015#_8c92ae1b_1591_40ca_acf3_12837ce8b76e
name: ATP5J
type: Species
has only substance units: false
boundary condition: true
is: Q6NZ59
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:522

metaR FATP1t
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110015#
fast: false
name: fatty acid electroneutral transport
modifier: MODEL1310110015#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaR r2099
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is described by: ECO:0000000

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110015#
reversible: true
fast: false

metaR r1177
is described by: ECO:0000000
name: EC:3.1.1.13
type: Reaction
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
reversible: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
kinetic law: MODEL1310110015#

metaR r2372
is: SBO:0000185
kinetic law: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

metaR UDPGLCAter
type: Reaction
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
modifier: MODEL1310110015#

metaR ACETONEt2
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: acetone transport via proton symport
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#

metaM ksii core2 g
has only substance units: false
constant: false
boundary condition: false
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01644
initial amount: NaN
is: CHEBI:17140
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

metaM CE1940 e
type: Species
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
constant: false
name: spermidine monoaldehyde 2
initial concentration: 1.0
is: HMDB02329
has only substance units: false
initial amount: NaN
boundary condition: false

metaR G14T4g
modifier: MODEL1310110015#
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR r2098
reactant: MODEL1310110015#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_e18e56f5_3044_4a53_b4fd_7e745ea861cd
is encoded by: hsa:6568
type: Species
has only substance units: false
name: SLC17A1
is: SBO:0000252
is: Q14916
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r2371
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM succ c
is: HMDB00254
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: Succinate
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
type: Species

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_3b7269c2_4247_46e3_b20e_f2da98b20adb
has part: P00325
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:125
has part: P07327
is: SBO:0000297
is encoded by: hsa:124
initial concentration: NaN
name: ADH1A:ADH1B
boundary condition: true
has only substance units: false

metaR PPDOy
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR PYNP2r
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
reversible: true
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: pyrimidine-nucleoside phosphorylase (uracil)
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9688a19e_986d_41da_afad_cd0cd8d27bbb
is: SBO:0000252
is encoded by: hsa:231
name: AKR1B1
boundary condition: true
has only substance units: false
is: P15121
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaR r2374
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#
is: SBO:0000185

metaR PROt2r
name: L-proline reversible transport via proton symport
fast: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR r2097
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaR PI4PLCn
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
reversible: false
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11

metaM n2m2masn g
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C11530
notes: FORMULA: C50H83N4O35X CHARGE: 0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM dhdascb c
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
name: dehydroascorbide(1-)
is: HMDB01264
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58070

http://identifiers.org/biomodels.db/MODEL1310110015#_20fbf6fa_3d95_45b2_ba85_9b7fe5a001f0
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: HK3
initial amount: NaN
boundary condition: true
type: Species
is: P52790
is encoded by: hsa:3101

metaR PPDOx
reactant: MODEL1310110015#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

metaM f1a l
type: Species
is: HMDB02917
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17151
is: SBO:0000247
name: F1alpha
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaM arach c
type: Species
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:32360
is: HMDB02212
boundary condition: false
name: arachidate
has only substance units: false

metaR r2373
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
product: MODEL1310110015#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000

metaM ksi deg23 l
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
name: keratan sulfate I, degradation product 23
boundary condition: false
initial concentration: 1.0
is: HMDB00143

metaR r2096
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR AG13T7g
type: Reaction
reversible: false
product: MODEL1310110015#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_7ad7084d_bafa_4dd9_8c15_a204230531ec
constant: false
initial concentration: NaN
name: COX4I1
initial amount: NaN
has only substance units: false
is encoded by: hsa:1327
boundary condition: true
type: Species
is: SBO:0000252
is: P13073

metaM succ e
boundary condition: false
name: succinate(2-)
initial concentration: 1.0
is: CHEBI:30031
type: Species
is: HMDB00254
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_0c477176_90c6_4845_bcee_ff572965890c
initial concentration: NaN
is encoded by: hsa:6524
boundary condition: true
initial amount: NaN
type: Species
is: P31639
is: SBO:0000252
has only substance units: false
name: SLC5A2
constant: false

metaM ps hs m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: ps_hs[m]
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303

metaM dhor S c
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (S)-dihydroorotate
is: HMDB03349
is: SBO:0000247
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial amount: NaN
type: Species
is: CHEBI:30864

metaM CE5586 c
has only substance units: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58732
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

metaM ksii core2 l
initial concentration: 1.0
is: HMDB01644
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17140
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM gluala e
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6503
is: HMDB06248
constant: false
name: 5-L-Glutamyl-L-alanine
is: C03740
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

metaM CE2838 e
constant: false
type: Species
name: maltononaose
is: C01936
is: SBO:0000247
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN

metaR r2095
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaM nadph c
is: SBO:0000247
has only substance units: false
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: C00005
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
boundary condition: false
constant: false

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110015#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaR DNDPt24m
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: dTDP transport via dADP antiport
reactant: MODEL1310110015#
reversible: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM xol7aone r
constant: false
is: SBO:0000247
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
is: HMDB01993
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_d1579e41_ed86_40e5_95da_d856bec42aff
name: NME4
boundary condition: true
has only substance units: false
initial amount: NaN
is: O00746
type: Species
initial concentration: NaN
is encoded by: hsa:4833
constant: false
is: SBO:0000252

metaR r2094
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110015#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false

metaR GLYCt
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: glycerol transport via channel
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110015#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185

metaR FAOXTC162TC142m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

metaM f1a g
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
is: HMDB02917
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:17151

http://identifiers.org/biomodels.db/MODEL1310110015#_70d68054_7ac0_4c05_b0fb_4750020aa24e
name: DGKZ
is: G3V0F6
is: SBO:0000252
type: Species
is encoded by: hsa:8525
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaM doco13ecoa x
name: 13-docosenoylcoa
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892791
initial amount: NaN
initial concentration: 1.0
type: Species

metaM ppi x
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:33019
is: HMDB00250
name: Diphosphate
is: C00013
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaM dolglcp U r
initial amount: NaN
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
has only substance units: false
is: CHEBI:15812
initial concentration: 1.0
constant: false
boundary condition: false

metaR BTNPLm
is: SBO:0000176
kinetic law: MODEL1310110015#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM pail34p hs c
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial amount: NaN
has only substance units: false
type: Species

metaM 3mgcoa m
is: CHEBI:57346
initial amount: NaN
is: HMDB01057
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: trans-3-methylglutaconyl-CoA(5-)
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial concentration: 1.0

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR NAHCO3 HCLt
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
is: SBO:0000185
reversible: true
modifier: MODEL1310110015#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110015#
type: Reaction

metaR r2377
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7d526110_b002_4242_8ee2_bf4f1f0b2fc5
has only substance units: false
name: ABAT
is encoded by: hsa:18
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR GACPAILter
reactant: MODEL1310110015#
fast: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
reversible: false
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
kinetic law: MODEL1310110015#

metaR r2092
product: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185

metaR G5SDym
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
is: SBO:0000176
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.41
product: MODEL1310110015#
name: glutamate-5-semialdehyde dehydrogenase (m)
is described by: ECO:0000254
fast: false

metaR r2091
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#

metaM mev R x
is: HMDB00227
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:36464
is: SBO:0000247
type: Species
constant: false
name: (R)-mevalonate

http://identifiers.org/biomodels.db/MODEL1310110015#_162e233e_331f_4f70_aa39_a6936c72c0b4
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: HKDC1
is encoded by: hsa:80201
initial amount: NaN
is: B3KT70
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_94727154_7e88_42bc_8549_2ada65090fe9
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: GMPR2
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9P2T1
is encoded by: hsa:51292

metaM ipdp x
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
has only substance units: false
is: SBO:0000247
is: HMDB01347
is: CHEBI:128769
name: isopentenyl diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110015#_6572a336_607a_44bf_87c9_77f8983ce424
type: Species
constant: false
is encoded by: hsa:9469
is: SBO:0000252
initial amount: NaN
is: Q7LGC8
boundary condition: true
name: CHST3
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c564948e_aac3_4017_8d5b_281cd82fe47d
initial concentration: NaN
boundary condition: true
is: P56134
is: SBO:0000252
initial amount: NaN
type: Species
name: ATP5J2
is encoded by: hsa:9551
has only substance units: false
constant: false

metaR 4MOPt2im
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_5c4beaf5_bb11_4020_85f1_f2db449fdfb3
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1384
is: P43155
is: SBO:0000252
name: CRAT

metaM pa hs n
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57739
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)

http://identifiers.org/biomodels.db/MODEL1310110015#_cf8b0afc_8d31_432c_bc40_a29b677f799b
is: O95864
has only substance units: false
is encoded by: hsa:9415
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: FADS2
initial amount: NaN

metaR FUMTSULtm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110015#
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
fast: false

metaR CSNAT3x
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
reversible: true
name: carnitine O-aceyltransferase, peroxisomal

metaR r2090
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110015#

metaR CYTDK2m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
reversible: false

metaR CSPG Atly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
name: chondroitin sulfate A transport, extracellular to lysosome
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false

metaM HC00695 m
name: S-Succinyldihydrolipoamide
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR TKT1
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.2.1.1
fast: false
name: transketolase
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000176

metaR DURItn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: deoxyuridine transport in nucleus
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c038e7b1_6390_425c_9721_26e9f6fbe4cf
constant: false
is: SBO:0000252
boundary condition: true
is: P26439
type: Species
initial concentration: NaN
name: HSD3B2
is encoded by: hsa:3284
has only substance units: false
initial amount: NaN

metaM arachdcrn r
name: C20:4 carnitine
is: HMDB06523
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57368
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

http://identifiers.org/biomodels.db/MODEL1310110015#_59cb23b3_f474_4bbe_91ef_d22018e39152
initial amount: NaN
constant: false
is: Q86VQ6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:114112
name: TXNRD3
boundary condition: true
type: Species

metaR r2379
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110015#
fast: false
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#

metaM dcsptn1coa c
has only substance units: false
is: HMDB06513
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_b272ae88_fc9e_4bf6_82f4_542aaa3d4df9
is: SBO:0000252
type: Species
name: ACP6
constant: false
initial amount: NaN
is encoded by: hsa:51205
is: Q9NPH0
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM pa hs m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57739
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
type: Species
name: phosphatidate(2-)
has only substance units: false

metaR DHCR71r
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: false
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.1.21

metaM dca r
notes: FORMULA: C10H19O2 CHARGE: -1
is: C14143
name: Decanoate (n-C10:0)
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB04047
is: SBO:0000247
type: Species

metaM ksi deg6 l
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
constant: false
name: keratan sulfate I, degradation product 6
boundary condition: false
has only substance units: false

metaR CYTK9n
product: MODEL1310110015#
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction

metaM nm4masn g
constant: false
type: Species
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
is: C05882
is: SBO:0000247

metaR CYTK11n
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110015#

metaM ppp9 m
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: Protoporphyrin
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
is: SBO:0000247
initial amount: NaN
is: HMDB00241
is: CHEBI:36159

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
name: proton diffusion (Golgi)
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR FAOXC141C121x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR r0488
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
kinetic law: MODEL1310110015#
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR HSD3A2r
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reactant: MODEL1310110015#

metaM lnlncacoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
boundary condition: false
constant: false
has only substance units: false
name: alpha-Linolenoyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:51985
is: HMDB06290
initial concentration: 1.0

metaR ADPT
name: adenine phosphoribosyltransferase
is: SBO:0000176
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
is described by: ECO:0000269
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#

metaR ASPNATm
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: aspartate N-acetyltransferase, mitochondrial
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110015#

metaM arachdcrn x
is: HMDB06523
is: SBO:0000247
name: C20:4 carnitine
has only substance units: false
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
boundary condition: false
is: CHEBI:57368
type: Species
initial concentration: 1.0

metaM pectintchol e
is: HMDB03402
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: pectin-taurocholic acid complex
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8f8c652a_ae4f_48ed_92c1_de6dbb814ee6
constant: false
is encoded by: hsa:8396
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P78356
type: Species
is: SBO:0000252
name: PIP4K2B

metaR ICDHyrm
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
reversible: true
name: Isocitrate dehydrogenase (NADP+)

http://identifiers.org/biomodels.db/MODEL1310110015#_202530c1_0b23_42cf_ba3a_4f8c9a1295a8
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: COX6A2
is: Q02221
has only substance units: false
is encoded by: hsa:1339
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_969b1037_d409_48e6_9e47_ca8b48df031d
constant: false
name: SLC34A2
is: O95436
is encoded by: hsa:10568
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_c82d0e6f_07fd_4bac_b3a7_29de2d2272fa
is: P11310
is: SBO:0000252
initial concentration: NaN
name: ACADM
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:34

metaM leuktrE4 c
initial concentration: 1.0
name: leukotriene E4(1-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
constant: false
is: HMDB02200
type: Species
boundary condition: false
is: SBO:0000247

metaR LNLCCRNt
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM xylt e
boundary condition: false
has only substance units: false
name: xylitol
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
is: HMDB02917
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_333fa100_5fc9_40f1_930e_f0b57661ce8c
is: P30613
initial amount: NaN
name: PKLR
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5313
constant: false

metaR TKT2
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is described by: ECO:0000000
name: transketolase
product: MODEL1310110015#
fast: false

metaM elaid e
is: SBO:0000247
initial amount: NaN
is: CHEBI:30825
is: HMDB00573
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
constant: false
name: elaidate

metaM dolmanp U r
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
is: CHEBI:15809

metaM nadph m
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
is: SBO:0000247
is: C00005
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: HMDB00221
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5a875963_b13e_46ac_a0c6_e9b8c560a5d1
initial amount: NaN
type: Species
name: PRPS1L1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:221823

metaM ppi r
initial amount: NaN
name: Diphosphate
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: C00013
constant: false
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110015#_20739bef_b1fb_435d_a3c6_f12af9ee0403
is encoded by: hsa:10991
is: Q99624
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: SLC38A3
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_d9cd7e7c_b4dd_4b0f_adb3_a25176da586a
constant: false
is: SBO:0000252
is encoded by: hsa:686
is: P43251
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: BTD

metaM adp r
initial concentration: 1.0
initial amount: NaN
name: ADP(3-)
is: CHEBI:456216
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110015#_5b914535_949c_4bbc_84e2_e2e4a9652198
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AL525798_1_c
constant: false
boundary condition: true
is encoded by: hsa:AL525798

metaR S6T11g
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM prostge2 e
constant: false
name: prostaglandin E2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
type: Species
boundary condition: false
is: HMDB01220
initial amount: NaN
is: CHEBI:606564
has only substance units: false
is: SBO:0000247

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM mi3p D c
is: CHEBI:58401
initial amount: NaN
type: Species
name: 1D-myo-inositol 3-phosphate(2-)
has only substance units: false
is: SBO:0000247
is: HMDB06814
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
constant: false

metaM HC00460 c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false

metaM succ m
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
has only substance units: false
is: HMDB00254
constant: false
is: SBO:0000247
is: C00042
initial concentration: 1.0
type: Species
initial amount: NaN
name: Succinate

metaR S4TASE3ly
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110015#

metaR HDDACBP
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM xylt c
boundary condition: false
is: SBO:0000247
name: xylitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
constant: false
initial concentration: 1.0
is: HMDB02917
type: Species
initial amount: NaN
has only substance units: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM leuktrE4 e
initial concentration: 1.0
constant: false
is: CHEBI:57462
name: leukotriene E4(1-)
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM ps hs e
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:18303
initial concentration: 1.0

metaR AG13T18g
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110015#

metaM elaid c
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
type: Species
initial amount: NaN
is: CHEBI:30825
initial concentration: 1.0
constant: false
name: elaidate
has only substance units: false
is: SBO:0000247

metaR CITL
reactant: MODEL1310110015#
reversible: false
product: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110015#
name: Citrate lyase
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR

metaM dctp n
is: CHEBI:16311
name: dCTP
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
type: Species
is: HMDB00998
constant: false
is: C00458
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_9b5e7322_ddd3_4afd_a7f0_d10d4dbfe4cd
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1743
is: P36957
type: Species
name: DLST
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_a17da2d9_55b2_4e56_9955_68205ef083a0
initial amount: NaN
is: SBO:0000252
name: G6PD
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: P11413
is encoded by: hsa:2539
boundary condition: true

metaR r0617
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110015#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true

metaR ACGALK
reactant: MODEL1310110015#
type: Reaction
name: N-acetylgalactosamine kinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176

metaM 2ddecdicoa m
has only substance units: false
initial amount: NaN
is: C05279
is: HMDB11123
name: 2,6-dodecadienoylcoa
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a8fad7ed_a320_49c4_a6e7_03e35dbe0ea7
initial concentration: NaN
constant: false
boundary condition: true
is: Q6IBB3
is encoded by: hsa:9551
name: ATP5J2
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR ADRNCOAtx
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: fatty acid intracellular transport
reversible: true
type: Reaction
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_19e582ea_3e2f_4442_b438_d09fa2b11322
name: _U37519_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:U37519
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR NOt
is: SBO:0000185
reversible: true
name: NO transport (diffusion)
type: Reaction
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f5788b4f_aa8f_4415_8089_b2b81d5b6d57
is: Q8TEQ8
boundary condition: true
name: PIGO
initial amount: NaN
is encoded by: hsa:84720
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_38de0545_9c76_41e0_aea2_1d7bd27832bc
boundary condition: true
constant: false
initial amount: NaN
is: P00558
is encoded by: hsa:5230
name: PGK1
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_989501f7_d652_48a5_af67_da28eef523b5
boundary condition: true
initial concentration: NaN
name: SLC1A4
initial amount: NaN
is: P43007
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6509

metaR r0616
kinetic law: MODEL1310110015#
reversible: true
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110015#

metaR RE3273C
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
fast: false
name: RE3273
reversible: true
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176

metaM cdpdag hs c
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58332
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_6bb4209e_228f_4505_bccc_8ddd809d8dc8
boundary condition: true
is: SBO:0000252
name: NT5C
constant: false
has only substance units: false
is encoded by: hsa:30833
is: Q8TCD5
type: Species
initial amount: NaN
initial concentration: NaN

metaM fuc L l
boundary condition: false
is: HMDB00174
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
type: Species
name: L-fucose
is: SBO:0000247
is: CHEBI:18287
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_501bf89c_bd96_4b89_ab66_44693d14c031
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6120
is: Q96AT9
has only substance units: false
name: RPE
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR FAEL184
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C20:4CoA)
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000176
fast: false

metaM succ x
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
has only substance units: false
is: CHEBI:30031
is: C00042
is: HMDB00254
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_41b42583_56c6_4dc9_b257_0a383645723f
boundary condition: true
type: Species
constant: false
is encoded by: hsa:501
is: SBO:0000252
name: ALDH7A1
initial amount: NaN
is: E7EPT3
has only substance units: false
initial concentration: NaN

metaM hs deg13 l
boundary condition: false
is: HMDB06210
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: SBO:0000247
name: heparan sulfate, degradation product 13
constant: false
initial amount: NaN

metaR RBK
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
fast: false
name: ribokinase
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.15
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR G14Tg
is: SBO:0000176
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM vitd3 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
has only substance units: false
type: Species
is: CHEBI:28940
constant: false
initial concentration: 1.0
name: calciol
is: HMDB00876

metaR MECOALm
is: SBO:0000176
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

metaM pan4p m
name: pantetheine 4'-phosphate(2-)
is: HMDB01416
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
name: glycerol transport
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185

metaR OCCOAtx
fast: false
product: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110015#
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000

metaR H2Otg
reactant: MODEL1310110015#
name: H2O transport, Golgi apparatus
type: Reaction
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_15c70506_ffe5_420b_9e6e_5482e0e7308c
initial amount: NaN
is encoded by: hsa:8527
name: DGKD
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_2a19bfc5_9dd4_4989_b94b_f9cd3085f6ae
type: Species
constant: false
is: SBO:0000252
name: PLA2G1B
is: P04054
initial amount: NaN
has only substance units: false
is encoded by: hsa:5319
initial concentration: NaN
boundary condition: true

metaR NDPK10n
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110015#
reversible: true
fast: false
product: MODEL1310110015#
type: Reaction

metaR FAEL183
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110015#

metaR ALAt2r
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
is: SBO:0000185
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR PSDm hs
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
name: Phosphatidylserine decarboxylase
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_51dc3551_721a_40ec_a467_97ec51bf5274
has only substance units: false
is encoded by: hsa:AI480132
type: Species
name: _AI480132_1_c
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR IDHPOXOX2b
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.8 Confidence Level: 4 AUTHORS: PMID:2997169 NOTES:SAB H + I instead of HI
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.8
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
reversible: false
product: MODEL1310110015#
fast: false
name: Iodide:hydrogen-peroxide oxidoreductase 2
reactant: MODEL1310110015#
is described by: ECO:0000269

metaM lac L c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00190
boundary condition: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
initial amount: NaN
name: (S)-lactate
constant: false
has only substance units: false

metaR r0494
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false

metaM crn m
has only substance units: false
initial amount: NaN
is: HMDB00062
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: SBO:0000247
constant: false
is: CHEBI:16347
name: L-Carnitine
initial concentration: 1.0
boundary condition: false

metaR MI1345PP
reversible: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
fast: false
product: MODEL1310110015#
modifier: MODEL1310110015#

metaR ICDHy
reversible: false
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
name: isocitrate dehydrogenase (NADP)

http://identifiers.org/biomodels.db/MODEL1310110015#_36579179_6492_4df7_afb2_3a05f471ec48
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:622
constant: false
is: SBO:0000252
type: Species
name: BDH1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b2d1c521_8ccd_4c5a_b92a_c15ca71e6c8a
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q6ZWP6
is encoded by: hsa:27034
initial amount: NaN
name: ACAD8

http://identifiers.org/biomodels.db/MODEL1310110015#_00f60d35_93b5_460c_ae10_433df82e3e76
is encoded by: hsa:3033
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q16836
name: HADH
constant: false
boundary condition: true

metaR H2Otm
name: H2O transport, mitochondrial
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
reversible: true
modifier: MODEL1310110015#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#

metaM ksi pre11 g
type: Species
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 11
constant: false

metaM pa hs c
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
boundary condition: false
name: phosphatidate(2-)
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_6546365e_29e2_4570_b0bc_62b29b9103dc
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q9BRB3
name: PIGQ
is encoded by: hsa:9091
initial amount: NaN
has only substance units: false
boundary condition: true

metaR Rtotaltl
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_e43d9e17_f631_49e4_96b5_1615082b7655
has only substance units: false
is encoded by: hsa:645
is: P30043
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: BLVRB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ac2d1093_0138_43dc_a1e9_8f3cf21b8e01
is encoded by: hsa:100
is: P00813
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ADA
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_2ec86706_d3c7_4236_97cb_ebb6c998334c
name: SLC22A2
is: O15244
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6582

metaR HMBS
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.5.1.61
name: hydroxymethylbilane synthase
kinetic law: MODEL1310110015#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_b2f3cd5b_211a_4eae_851f_7041231f4c3f
has only substance units: false
type: Species
name: ALDH2
initial amount: NaN
constant: false
is: P05091
is encoded by: hsa:217
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM lac L e
has only substance units: false
type: Species
is: HMDB00190
is: CHEBI:16651
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
boundary condition: false
constant: false
name: (S)-lactate

http://identifiers.org/biomodels.db/MODEL1310110015#_0d696be1_12c2_4780_a6bc_14ccb1e3c94b
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SRD5A1
boundary condition: true
type: Species
is: P18405
is encoded by: hsa:6715
constant: false

metaR NRPPHRt4 2 r
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true

metaR r1397
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: carnitine acetyltransferase EC:2.3.1.7
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reversible: false
fast: false

metaM glyb c
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
is: CHEBI:17750
name: glycine betaine
boundary condition: false
initial amount: NaN

metaM hs deg6 l
constant: false
is: HMDB06210
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
name: heparan sulfate, degradation product 6
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_d3384562_0c5b_4888_b21c_f9478d99c0ba
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6548
is: P19634
name: SLC9A1
constant: false
has only substance units: false
boundary condition: true

metaM ala B e
is: CHEBI:16958
type: Species
boundary condition: false
has only substance units: false
name: beta-alanine
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg39 l
has only substance units: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0
constant: false
is: HMDB00143
name: keratan sulfate I, degradation product 39

http://identifiers.org/biomodels.db/MODEL1310110015#_7a610275_5e21_48e2_8fb0_688da72574c5
initial amount: NaN
has only substance units: false
constant: false
is: P19801
type: Species
is: SBO:0000252
is encoded by: hsa:26
name: ABP1
boundary condition: true
initial concentration: NaN

metaR C3STKR2r
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
fast: false
name: C-3 sterol keto reductase (zymosterol)
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110015#_10438a64_cbd0_4c45_adca_040a2f9b4c0f
name: PMVK
is: SBO:0000252
is: Q6FGV9
initial amount: NaN
is encoded by: hsa:10654
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r0615
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_33b0e02c_a0da_4f9b_ab0d_1ddc7d17ab98
is encoded by: hsa:126
has part: P00326
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: ADH1A:ADH1C
has only substance units: false

metaM eicostetcoa c
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: eicosatetranoyl coenzyme A
is: C16164
boundary condition: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR LEUtec
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: L-leucine transport via diffusion (extracellular to cytosol)
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_4fd1f4ab_5a98_4603_9d5c_7f22d409dbe3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:65263
type: Species
name: PYCRL
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110015#_80cd8b42_f2fd_4546_8caa_59f7c571652a
constant: false
is encoded by: hsa:8801
has only substance units: false
has part: Q96I99
is encoded by: hsa:8802
boundary condition: true
is: SBO:0000297
has part: P53597
name: SUCLG2:SUCLG1
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_fd13847a_6bed_4b1e_8d9d_6d351eda12d4
constant: false
boundary condition: true
is: Q9NY65
initial amount: NaN
is encoded by: hsa:1962
type: Species
name: EHHADH
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0614
is described by: ECO:0000000
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

metaM crn r
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: (R)-carnitine
is: CHEBI:16347
is: SBO:0000247

metaR NCKt
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
name: Na+/Ca2+-K+ exchange
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false
product: MODEL1310110015#

metaM ala B c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
name: beta-alanine
constant: false
initial concentration: 1.0
is: CHEBI:16958
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR LTD4DP
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
is described by: ECO:0000000

metaR ARACHDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: fatty acid intracellular transport

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_7bf0c977_7325_464d_8f4d_eb119ef56e15
is: P28329
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8040dd98_f677_47dd_b30e_271781a4c5f0
has only substance units: false
name: GLUD1
initial concentration: NaN
is encoded by: hsa:2746
initial amount: NaN
boundary condition: true
type: Species
is: E9KL48
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_a9af11d2_85b5_4f9e_b4e1_fdf7ac5fd408
is encoded by: hsa:514
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
is encoded by: hsa:513

metaM pail345p hs c
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57836
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_3c093a77_1ee3_4711_867e_46a039dd116e
is encoded by: hsa:80025
name: PANK2
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9BZ23
initial concentration: NaN
initial amount: NaN

metaR Htr
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: H transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR CITtbm
fast: false
is: SBO:0000185
modifier: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
name: citrate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110015#_06d47f35_b260_4b57_b8fb_a61abdcbc8e8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HK1
is encoded by: hsa:3098
type: Species
constant: false
is: P78542
boundary condition: true

metaR S6TASE20ly
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110015#

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaM adp e
initial concentration: 1.0
boundary condition: false
name: ADP(3-)
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
type: Species
initial amount: NaN
is: HMDB01341

metaM HC02187 c
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
name: reverse-triiodthyronine
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r1866
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110015#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR IDOURte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
reversible: true
name: L-iduronate transport, extracellular
reactant: MODEL1310110015#
is described by: ECO:0000134
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#

metaR MI3PP
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
reversible: false
product: MODEL1310110015#
modifier: MODEL1310110015#
name: myo-inositol 3-phosphatase
kinetic law: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110015#
type: Reaction

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
type: Reaction
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is described by: ECO:0000134

metaR FAOXC81C61m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: Diacylglycerol phosphate kinase (homo sapiens)
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.107

metaR FAOXC225C226m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_f94753e7_0740_497e_8ffb_4141fbd24e18
initial amount: NaN
constant: false
type: Species
name: ADH4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:127
is: P08319
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_fd055d24_d134_404f_96e5_e30fc854c6ab
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PANK2
is: SBO:0000252
is encoded by: hsa:80025
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_f75da873_4b78_439f_8590_7cf905d30d7a
initial concentration: NaN
initial amount: NaN
is: E7EPT3
name: ALDH7A1
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:501
constant: false

metaR SCPx
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.176
name: peroxisomal thiolase 2

metaR RE1518M
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r2520
reversible: true
reactant: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false
type: Reaction

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
is: SBO:0000185

metaM HC02217 c
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:27647
type: Species
is: SBO:0000247
name: prostaglandin-g2
has only substance units: false

metaR H2Otp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
name: H2O transport, peroxisomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_4015993d_917d_442d_b349_cff90cebca65
boundary condition: true
initial concentration: NaN
is: B4E097
is encoded by: hsa:2592
constant: false
has only substance units: false
is: SBO:0000252
name: GALT
initial amount: NaN
type: Species

metaM HC01415 m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27537
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA
boundary condition: false

metaM fuc L c
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: L-fucose
initial concentration: 1.0
is: CHEBI:18287
constant: false
is: HMDB00174

metaR L LACDcm
modifier: MODEL1310110015#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_f2daa5ea_56cb_442a_aa8c_62d238da9dc7
name: SULT1A3
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6818
constant: false

metaM dgdp c
initial concentration: 1.0
name: dGDP
is: C00361
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
is: CHEBI:58595
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

metaR FAOXC121C10x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_00e7bd10_87bf_4d91_bbb5_db376199d077
is encoded by: hsa:955
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O75354
boundary condition: true
type: Species
name: ENTPD6

metaR r1396
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
name: EC:2.3.1.21
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d5f6f3a1_760a_4529_8030_5c37e99d2ae5
is: P41222
is encoded by: hsa:5730
is: SBO:0000252
initial amount: NaN
name: PTGDS
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r2521
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Utilized transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_f9a4ab4f_313b_488c_94d8_4a4e096ba7c2
initial amount: NaN
is encoded by: hsa:954
is: SBO:0000252
name: ENTPD2
is: Q9Y5L3
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110015#
type: Reaction
name: sph1p transport

metaM dolp L r
has only substance units: false
name: dolichyl phosphate(2-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57683
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_94e5e069_4bda_45a4_8145_707c3e20683f
type: Species
is: P54819
boundary condition: true
initial amount: NaN
is encoded by: hsa:204
is: SBO:0000252
constant: false
name: AK2
initial concentration: NaN
has only substance units: false

metaM fuc L e
initial amount: NaN
boundary condition: false
constant: false
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
type: Species
is: CHEBI:18287
is: HMDB00174
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR H2Otn
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
name: H2O transport, nuclear

metaR GluForTx
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
modifier: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
reversible: false
name: Glutamate formimidoyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.5

metaM ksi pre33 g
boundary condition: false
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 33
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
constant: false
is: C00130
initial concentration: 1.0

metaR PRASCS
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.2.6
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

http://identifiers.org/biomodels.db/MODEL1310110015#_b1ddf7b0_40a3_42e6_94f5_b30953cc0612
type: Species
initial amount: NaN
is: SBO:0000252
name: PRDX1
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_25c80dc3_ad47_42e5_a923_c5ffd49be836
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6799
is: SBO:0000252
has only substance units: false
name: SULT1A2
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_9bceb564_7692_4823_a002_0f977e13c1ce
is encoded by: hsa:210
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: P13716
initial concentration: NaN
is: SBO:0000252
name: ALAD

http://identifiers.org/biomodels.db/MODEL1310110015#_1dbb9a43_45a4_4599_9934_5c7501c8196c
has only substance units: false
initial amount: NaN
is encoded by: hsa:375056
constant: false
is: Q5JRA6
name: MIA3
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM dcsptn1coa m
initial concentration: 1.0
is: C16173
is: SBO:0000247
type: Species
is: HMDB06513
has only substance units: false
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN

metaM dctp c
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
initial amount: NaN
is: HMDB00998
name: dCTP
is: CHEBI:16311
type: Species
is: C00458
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e31f791d_ea3c_4e81_9ab8_288724cef1b6
initial concentration: NaN
is encoded by: hsa:AA614647
name: _AA614647_1_c
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR SRTNt6 2 r
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
reversible: true
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ba123535_b94d_4a91_ad07_f8289663162a
has only substance units: false
boundary condition: true
name: _AI769281_1_e
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AI769281

metaM crn x
initial amount: NaN
constant: false
is: HMDB00062
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
name: L-Carnitine
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00318
type: Species

metaR Htx
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
name: H transporter, peroxisome
fast: false

metaM hexdectecoa m
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02288
initial amount: NaN
has only substance units: false
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110015#_221102e9_2332_4434_a84f_a5d898fb6483
boundary condition: true
has only substance units: false
is encoded by: hsa:2629
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: GBA
initial concentration: NaN

metaM C04853 r
is: CHEBI:57460
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/p-1/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C04853
initial amount: NaN
name: 20-hydroxy-leukotriene B4(1-)
is: HMDB01509
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaR DGCHOLte
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reactant: MODEL1310110015#
reversible: true
fast: false
name: bile acid intracellular transport
kinetic law: MODEL1310110015#
is described by: ECO:0000000

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_d561c01e_d4fd_4e23_801a_d7aea9ee9f6a
constant: false
is: SBO:0000252
boundary condition: true
name: NME1
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4830
initial concentration: NaN

metaM xan c
is: SBO:0000247
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00292
is: CHEBI:17712

metaR M16N6Tg
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.155
modifier: MODEL1310110015#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (4249.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.155 Confidence Level: 0 AUTHORS: NOTES:NCD
name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR ATPS4m
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.14
is: SBO:0000185
modifier: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
name: ATP synthase (four protons for one ATP)
is version of: http://identifiers.org/ec-code/3.6.4.6
is version of: http://identifiers.org/ec-code/3.6.3.14
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
type: Reaction

metaM HC02187 e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28774
initial amount: NaN
constant: false
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species

metaM zymstnl r
is: HMDB06841
boundary condition: false
is: CHEBI:16608
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
type: Species
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR r2525
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM adp c
constant: false
is: CHEBI:16761
initial amount: NaN
boundary condition: false
name: ADP
is: HMDB01341
type: Species
has only substance units: false
is: C00008
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3310

http://identifiers.org/biomodels.db/MODEL1310110015#_07301b89_b40a_4f4d_9fdb_b44797ca392b
constant: false
is: Q9H477
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:64080
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: RBKS

metaM xu1p D c
type: Species
is: HMDB06534
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
constant: false
initial amount: NaN
name: D-Xylulose 1-phosphate
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM cdpdag hs m
is: CHEBI:58332
initial concentration: 1.0
constant: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN
name: CDP-diacylglycerol(2-)
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR r2526
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
type: Reaction
product: MODEL1310110015#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaM betald c
is: SBO:0000247
type: Species
is: HMDB01252
initial amount: NaN
is: CHEBI:15710
has only substance units: false
boundary condition: false
name: betaine aldehyde
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576

http://identifiers.org/biomodels.db/MODEL1310110015#_4c17003a_e903_4970_b729_d805683578f6
boundary condition: true
name: CROT
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:54677
is: E7EQF2
initial amount: NaN

metaR TAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#

metaR ARACHDtr
is described by: ECO:0000000
reactant: MODEL1310110015#
name: intracellular transport
kinetic law: MODEL1310110015#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
product: MODEL1310110015#

metaR CRNrtx
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
name: reversible transport of L-Carnitine in peroxisome

http://identifiers.org/biomodels.db/MODEL1310110015#_c007b069_cdc3_4125_b75a_9dc2c3bab333
constant: false
is encoded by: hsa:100128062
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _100128062_1_m
type: Species
initial amount: NaN
initial concentration: NaN

metaM HC02217 e
has only substance units: false
name: prostaglandin-g2
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
is: CHEBI:27647
boundary condition: false
is: SBO:0000247

metaM tetde5coa x
name: 5-tetradecenoylcoa
constant: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
is: HMDB13109
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r2388
reversible: false
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110015#
is: SBO:0000185

metaR CYANt
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
name: Cyanide transport via diffusion (extracellular to cytosol)
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM

metaM dcamp c
name: N6-(1,2-Dicarboxyethyl)-AMP
initial amount: NaN
is: CHEBI:57567
is: C03794
is: HMDB00536
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9ab17b7b_f359_42c6_a8a1_8355243d6f6d
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
name: ST3GAL3
constant: false

metaR FAOXC204C184m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_6825d217_a551_4ee5_8416_f85632f021cc
is: SBO:0000252
boundary condition: true
is: Q9Y2Q0
type: Species
name: ATP8A1
initial amount: NaN
is encoded by: hsa:10396
constant: false
has only substance units: false
initial concentration: NaN

metaR RE0383C
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: RE0383
fast: false
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR DNDPt10m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
name: dADP transport via dCDP antiport
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_0bb6835a_d9fc_4175_a13e_ed5d14caaf92
is: P49619
initial amount: NaN
has only substance units: false
is encoded by: hsa:1608
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: DGKG

metaR PSSA2 hs
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.7.8.29
type: Reaction
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
name: Phosphatidylserine synthase homo sapiens
modifier: MODEL1310110015#
is described by: ECO:0000269

metaR r2387
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ebf67c09_91ca_41cd_9c0c_7cd5b5aff3c8
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACOX1
is: B4DK61
has only substance units: false
is encoded by: hsa:51

metaR AG13T8g
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_8680fc5e_d0a5_42a3_a2ce_be0524782ced
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4831
has only substance units: false
has part: P22392
name: NME1:NME2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4830
has part: P15531
is: SBO:0000297

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM hdd2coa m
boundary condition: false
is: CHEBI:61526
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
initial amount: NaN
type: Species
is: HMDB03945
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7ee619b7_ab73_44a0_9cdd_572ed0ea2b27
is encoded by: hsa:1371
is: P36551
type: Species
name: CPOX
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM tdchola e
is: HMDB00951
type: Species
initial concentration: 1.0
is: CHEBI:9407
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

http://identifiers.org/biomodels.db/MODEL1310110015#_419f2a4b_e060_426d_af9c_8d5d7bff5fcf
is encoded by: hsa:AA526438
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: _AA526438_1_m

metaR DM dgpi prot hs r
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_ae6963b4_cef4_4cff_aaeb_71247addb433
is encoded by: hsa:1633
constant: false
boundary condition: true
initial concentration: NaN
is: P27707
type: Species
initial amount: NaN
name: DCK
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2985c0f1_7aa0_4bf3_8ed0_f28701f4d77e
initial amount: NaN
is encoded by: hsa:55753
name: OGDHL
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q9ULD0

metaR FAOXTC102C101m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5b908a42_4fcb_4a0d_992c_350ef51a6dde
is encoded by: hsa:50484
constant: false
is: Q7LG56
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: RRM2B
type: Species

metaR r2386
is: SBO:0000185
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_a5679067_5f65_443b_9081_32f3adcafc45
initial amount: NaN
name: BDH1
boundary condition: true
has only substance units: false
is encoded by: hsa:622
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR DADNt4
name: deoxyadenosine transport via diffusion
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM acetone m
name: acetone
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
is: CHEBI:15347
is: HMDB01659
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_413ff646_7ca5_4fc3_a8ac_f118b35cb6af
constant: false
initial concentration: NaN
name: _AI761708_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI761708
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_93ec5702_f0e3_4d66_b025_ad3bb33b6e20
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23428
is: SBO:0000252
is: Q86U05
has only substance units: false
type: Species
initial amount: NaN
name: SLC7A8

http://identifiers.org/biomodels.db/MODEL1310110015#_4f06c879_538a_493a_98f9_5abb803c4fec
initial concentration: NaN
has only substance units: false
constant: false
name: MTMR6
boundary condition: true
is: Q9Y217
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9107

http://identifiers.org/biomodels.db/MODEL1310110015#_453007f4_80aa_414c_8b75_c6f9acf9b7d9
is encoded by: hsa:123041
is: Q8NFF2
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC24A4
type: Species

metaM xol7ah2al c
is: SBO:0000247
is: HMDB06894
is: CHEBI:27428
boundary condition: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_b146f7d1_10bd_4475_ae41_e5d6c8753472
initial amount: NaN
name: DYLX2
type: Species
is: F5H123
boundary condition: true
is encoded by: hsa:9856
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c35accdf_34dc_4d26_abb3_fc3541b21f75
name: COX5B
has only substance units: false
is: Q53YB7
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1329

metaR THYOXt2
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
name: T4 transport via facilitated diffusion
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction

metaR r2385
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c80cb9d6_62f4_4771_996c_b1bac87ffde6
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: P11182
is: SBO:0000252
constant: false
name: DBT
initial concentration: NaN
is encoded by: hsa:1629

metaR S6T1g
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM glyald c
is: C00577
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17378
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
constant: false
type: Species
initial concentration: 1.0

metaR CYTK6n
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110015#
name: cytidylate kinase (CMP,CTP),nuclear
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_6473ff43_8514_44e1_9db4_b03874d93166
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: _AA576959_1_c
is: SBO:0000252
is encoded by: hsa:AA576959
initial amount: NaN

metaM 4hpro LT m
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00725
constant: false
is: CHEBI:18095
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

metaR G6PPer
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
name: glucose-6-phosphate phosphatase, edoplasmic reticular
is version of: http://identifiers.org/ec-code/3.1.3.9
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
fast: false
reactant: MODEL1310110015#
is: SBO:0000176

metaM tdchola c
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00951
is: CHEBI:9407
has only substance units: false
initial amount: NaN
constant: false
name: taurochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

http://identifiers.org/biomodels.db/MODEL1310110015#_160f6ded_2c7f_4133_b583_cdc8eebd9f0b
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q8TF08
is encoded by: hsa:170712
initial amount: NaN
name: COX7B2

metaR EHGLATm
modifier: MODEL1310110015#
reversible: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110015#
fast: false
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110015#_d6a73b8b_7eab_419e_9a8f_fe63c148a942
name: PPA2
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27068
type: Species
is: Q9H2U2
has only substance units: false
boundary condition: true
initial amount: NaN

metaM zym int2 r
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
is: CHEBI:52386
is: SBO:0000247
constant: false
has only substance units: false
name: zymosterol intermediate 2
boundary condition: false
initial concentration: 1.0

metaR r2384
kinetic law: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110015#
fast: false
is: SBO:0000185
product: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR ACOAO7p
product: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reversible: false
fast: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110015#

metaM HC01397 x
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: (S)-3-Hydroxyhexadecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110015#_9942c332_6bab_4a02_8276_e4a8c7565376
initial amount: NaN
is: Q9UI32
is encoded by: hsa:27165
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: GLS2

metaR GLU5Km
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
is version of: http://identifiers.org/ec-code/1.2.1.41
kinetic law: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
name: glutamate 5-kinase (m)
product: MODEL1310110015#
reversible: false
fast: false
is described by: ECO:0000254
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_115c0e30_d5ec_4a15_9838_8a7a526dc4d2
constant: false
name: SLC24A2
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:25769
initial concentration: NaN
is: Q9UI40
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_0557ee46_3033_42fe_97d2_6230a9ed0841
name: CA6
has only substance units: false
is: Q5FC00
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:765

metaM cala c
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: HMDB00026
name: N-carbamoyl-beta-alaninate
is: SBO:0000247
has only substance units: false
is: CHEBI:11892
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR RBTt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
name: ribitol transport via passive diffusion

metaM hs deg14 l
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
type: Species
name: heparan sulfate, degradation product 14
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false

metaR FAOXC227C226m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_83bc8978_f2d5_4d40_8117_c23825515a83
has only substance units: false
constant: false
is encoded by: hsa:6241
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P31350
name: RRM2

metaM gpi prot hs r
initial concentration: 1.0
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
constant: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
has only substance units: false
is: CHEBI:7896
is: C00249
is: HMDB00220
type: Species
is: SBO:0000247
boundary condition: false

metaM 3hexdtetcoa m
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 3,7,10,13-hexadecatetraenoylcoa

metaR FAOXC122C101m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM sarcs m
is: HMDB00271
is: CHEBI:15611
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00213
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: Sarcosine
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213

metaM q10 e
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
initial amount: NaN
name: ubiquinone-10
is: HMDB01072
has only substance units: false
initial concentration: 1.0
is: CHEBI:46245
boundary condition: false
type: Species

metaM maltttr e
is: http://identifiers.org/pubchem.compound/5141
type: Species
initial amount: NaN
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296
name: Maltotetraose
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C02052
initial concentration: 1.0

metaR ADSS
is: SBO:0000176
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.4.4
fast: false
product: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110015#
name: adenylosuccinate synthase

http://identifiers.org/biomodels.db/MODEL1310110015#_c8875407_ac86_4127_8518_49f67c1fcfc8
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC26A2
has only substance units: false
is: P50443
is encoded by: hsa:1836
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_4186195a_812a_49e1_bf3b_74d4b8f06c57
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4056
is: Q16873
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: LTC4S

metaR CEPTE
name: ethanolamine phosphotransferase
reversible: false
fast: false
product: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.2
kinetic law: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaR r0926
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
kinetic law: MODEL1310110015#
name: Postulated transport reaction
is: SBO:0000185
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR r2382
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000

metaR CYTK14n
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110015#

metaM xoltriol c
initial amount: NaN
is: SBO:0000247
is: HMDB01457
constant: false
has only substance units: false
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
initial concentration: 1.0
is: CHEBI:16496

metaR URIt
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000269
name: uridine facilated transport in cytosol
fast: false
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaM pmtcoa x
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: SBO:0000247
is: C00154
constant: false
is: HMDB01338
has only substance units: false
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
type: Species
initial concentration: 1.0

metaM mpdol U c
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:18396
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_64f02e6e_53b5_4152_9d8b_15d74bfc0503
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:T83654
has only substance units: false
name: _T83654_1_c

metaM o2 x
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
type: Species
is: CHEBI:15379
is: HMDB01377
has only substance units: false
initial concentration: 1.0
name: O2
constant: false
boundary condition: false
initial amount: NaN

metaM bhb m
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: SBO:0000247
constant: false
is: HMDB00011
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b80402f3_f46a_40e4_9ce0_df92a4db8ad7
has only substance units: false
is encoded by: hsa:D29675
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _D29675_1_c
constant: false
is: SBO:0000252

metaR DHFR
reversible: true
reactant: MODEL1310110015#
name: dihydrofolate reductase
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
type: Reaction

metaR G14T5g
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
modifier: MODEL1310110015#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4177fcdd_7499_4b09_a9be_f79bdc5db6b3
name: ALDOA
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:226

http://identifiers.org/biomodels.db/MODEL1310110015#_6e1d84e4_5441_4677_a42c_ceffdd6f9145
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: AKR1C4
has only substance units: false
is: P17516
is encoded by: hsa:1109
boundary condition: true
is: SBO:0000252

metaR ACGAMtly
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: N-acetyl-glucosamine lysosomal efflux
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD

metaM 2mb2coa m
is: HMDB02054
has only substance units: false
is: CHEBI:57337
constant: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
initial amount: NaN
boundary condition: false
name: 2-methylcrotonoyl-CoA(4-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_596b1702_87e9_4756_b232_1d8c8c764752
constant: false
is: Q8WVQ1
initial concentration: NaN
type: Species
is encoded by: hsa:124583
is: SBO:0000252
boundary condition: true
name: CANT1
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_f6103958_5bd8_4b8f_a9b0_969f4135324a
is: SBO:0000252
initial concentration: NaN
constant: false
name: AMY2A
is encoded by: hsa:279
type: Species
boundary condition: true
is: P04746
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1c2c4866_3f59_4dd9_8127_2ceab3ea5b2f
is encoded by: hsa:8854
initial concentration: NaN
type: Species
name: ALDH1A2
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: B4DZR2
is: SBO:0000252

metaR AMPtp
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
name: AMP transporter, peroxisome

metaR CEPTC
is: SBO:0000176
reactant: MODEL1310110015#
reversible: false
product: MODEL1310110015#
name: choline phosphotransferase
fast: false
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.8.2
type: Reaction

metaR UDPtl
reversible: true
fast: false
name: udp intracellular transport
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#

metaM acetone c
boundary condition: false
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
initial concentration: 1.0
is: HMDB01659
type: Species
name: acetone
is: SBO:0000247
has only substance units: false
is: CHEBI:15347

http://identifiers.org/biomodels.db/MODEL1310110015#_7f367bd1_6a15_4745_957a_576edf9e72bf
is: Q7Z3X3
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2799
constant: false
name: GNS
has only substance units: false
type: Species

metaM phytcoa c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: phytanoyl-CoA(4-)
has only substance units: false
is: CHEBI:57391
constant: false
type: Species
is: HMDB01359
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1

metaM co c
name: carbon monoxide
initial amount: NaN
constant: false
is: HMDB01361
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_df3c4e2d_690f_4099_a696_d721e91a90ce
boundary condition: true
has only substance units: false
is encoded by: hsa:27068
name: PPA2
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaR C226CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
type: Reaction
modifier: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
name: C226 transport into the mitochondria
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_e97639a6_8bbc_4fd0_a5ea_534fc427b1eb
name: FUT8
is encoded by: hsa:2530
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9BYC5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2e5dba86_0c64_491f_8685_575d587d4158
has only substance units: false
type: Species
boundary condition: true
name: NDUFA9
is: SBO:0000252
constant: false
is: Q16795
is encoded by: hsa:4704
initial concentration: NaN
initial amount: NaN

metaR r1466
is described by: ECO:0000000
reversible: true
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: EC:2.3.1.86
fast: false
is: SBO:0000176
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_6bc6a22a_0122_445a_beff_aa103e35697f
constant: false
initial concentration: NaN
boundary condition: true
is: P51828
is: SBO:0000252
has only substance units: false
is encoded by: hsa:113
initial amount: NaN
name: ADCY7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_77ca186c_8232_4021_83e9_5bdcefb964e6
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q14032
name: BAAT
is encoded by: hsa:570
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_bc710f23_71db_4b13_b42b_59966be7275e
boundary condition: true
name: ACO1
type: Species
is encoded by: hsa:48
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P21399
constant: false

metaM acmana r
type: Species
is: SBO:0000247
name: N-acetyl-D-mannosamine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110015#_bbbf53d9_c888_4b49_985a_ab589b652990
initial amount: NaN
has only substance units: false
is: O95395
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9245
name: GCNT3

metaR r1467
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_db3e8175_e501_49c8_9f94_8612c8596a5f
type: Species
is: SBO:0000252
constant: false
name: SLC5A12
boundary condition: true
initial concentration: NaN
is: Q1EHB4
is encoded by: hsa:159963
initial amount: NaN
has only substance units: false

metaR GULN3D
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110015#_d902589f_86e5_4e18_9483_1db015b01264
is: Q15392
boundary condition: true
type: Species
name: DHCR24
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1718
is: SBO:0000252

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
name: dGDP(2-)
constant: false
initial amount: NaN
is: CHEBI:58595
is: HMDB00960
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_bd3510e6_c57e_4ac4_bd99_a4bafc365f8f
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: SORD
constant: false
is encoded by: hsa:6652
is: Q00796
type: Species
initial concentration: NaN

metaM acetone e
is: HMDB01659
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: acetone
is: CHEBI:15347

metaR NACHEX16ly
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110015#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_b2069c82_6e94_452c_a828_d8e6ecbd8eb3
initial amount: NaN
is: SBO:0000252
is: Q96CA6
type: Species
has only substance units: false
is encoded by: hsa:30
boundary condition: true
constant: false
initial concentration: NaN
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110015#_03b3ace3_e6ca_4bc4_81a8_10fe28aa38a3
initial concentration: NaN
type: Species
name: _H45672_1_m
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:H45672
boundary condition: true

metaM CE4794 m
has only substance units: false
initial amount: NaN
is: CHEBI:57923
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
boundary condition: false
name: cis-6-dodecenoyl-CoA

metaM ppcoa x
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: Propanoyl-CoA
boundary condition: false
constant: false
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
initial amount: NaN
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110015#_e4904497_b7c1_45ec_b01d_f0e862917e19
is encoded by: hsa:10400
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: PEMT
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_68e68a34_144b_4b54_9ab8_0ff53c090fd9
constant: false
has only substance units: false
name: PLD1
type: Species
boundary condition: true
is: Q59EA4
is encoded by: hsa:5337
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM dgdp n
type: Species
has only substance units: false
is: CHEBI:58595
is: HMDB00960
name: dGDP(2-)
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0

metaR DHCR72r
modifier: MODEL1310110015#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
fast: false
type: Reaction
name: 7-dehydrocholesterol reductase
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaR FAOXC164m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaM pan4p c
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: CHEBI:47942
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01416
name: Pantetheine 4'-phosphate
is: C01134
initial concentration: 1.0

metaM 44mzym r
boundary condition: false
is: HMDB01286
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: 14-demethyllanosterol
is: CHEBI:18364
type: Species
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaR r1811
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR 13DAMPPOX
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110015#
type: Reaction
reversible: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
is described by: ECO:0000212
is: SBO:0000176

metaR C226CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine C22:6 transferase
modifier: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176
product: MODEL1310110015#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_380ae29c_dfbe_4d9d_b884_22e4a1ff875e
is: Q76EJ3
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:11046
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC35D2

http://identifiers.org/biomodels.db/MODEL1310110015#_b93513d4_2157_4c45_93f0_996cbf58339b
name: TPO
is encoded by: hsa:7173
has only substance units: false
boundary condition: true
is: Q6P534
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaM q10 c
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ubiquinone-10
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072

metaR PCHOLPm hs
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
name: choline phosphatase
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction

metaR r1692
reversible: false
kinetic law: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#

metaR CLOXAtex2
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
type: Reaction
modifier: MODEL1310110015#
name: chloride transport via oxalate countertransport (2:1)
reversible: false
kinetic law: MODEL1310110015#
is: SBO:0000185

metaM dhlpro m
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: Dihydrolipolprotein
has only substance units: false
is: CHEBI:16194
type: Species
initial concentration: 1.0
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972

metaM icit m
has only substance units: false
name: Isocitrate
is: HMDB00193
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16087
is: C00311

metaR G14T16g
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM pail35p hs c
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

metaM andrstrn r
is: CHEBI:16032
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
boundary condition: false
constant: false
name: androsterone
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00031

http://identifiers.org/biomodels.db/MODEL1310110015#_d9c76979_cdff_4092_ad3c_e43cea2611ca
constant: false
boundary condition: true
is encoded by: hsa:4723
initial amount: NaN
name: NDUFV1
is: E5KNH5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR GDPFUCtg
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: GDPFuc Golgi transport via CMP antiport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6dd15ebe_e8cc_4018_8bc3_b27626544ae5
initial concentration: NaN
is: Q9HAB8
has only substance units: false
boundary condition: true
name: PPCS
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:79717
constant: false

metaR PIK3
reversible: false
modifier: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol 3-kinase
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.137
reactant: MODEL1310110015#

metaR ADK1m
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
name: adenylate kinase, mitochondrial
type: Reaction
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
reversible: true
kinetic law: MODEL1310110015#

metaM sarcs e
constant: false
name: sarcosine
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
initial concentration: 1.0
is: HMDB00271
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15611

metaM HC01602 c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
is: C00234
name: 10-Formyltetrahydrofolate
has only substance units: false

metaM hexc e
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
boundary condition: false
constant: false
is: CHEBI:31013
is: SBO:0000247
name: cerotate
initial concentration: 1.0
type: Species
is: HMDB02356
initial amount: NaN
has only substance units: false

metaM pan4p e
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
is: SBO:0000247
is: C01134
boundary condition: false
name: Pantetheine 4'-phosphate
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB01416

http://identifiers.org/biomodels.db/MODEL1310110015#_999d523b_6a72_46b8_9ccf_0eb47b3c896c
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PRDX1
is: Q06830
type: Species
is encoded by: hsa:5052
is: SBO:0000252

metaR FUMSO4tm
product: MODEL1310110015#
modifier: MODEL1310110015#
name: Fumarate:sulfate antiport, mitochondrial
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
fast: false

metaR ARSA
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
product: MODEL1310110015#
name: Arylsulfatase A
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.8
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_188ab9e1_5dbf_43e9_929b_89166f41fe6a
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: P51857
initial concentration: NaN
is encoded by: hsa:6718
name: AKR1D1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_665a56d9_bda7_445c_a6b3_5a7575fe8732
name: SYNJ2
type: Species
is: O15056
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8871
initial concentration: NaN
boundary condition: true

metaR r1693
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GGT5r
type: Reaction
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
name: Gamma-glutamyltransferase 5
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ

http://identifiers.org/biomodels.db/MODEL1310110015#_35454ba8_9b83_489a_979c_ba2f21b9d9f5
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AA629629
name: _AA629629_1_m

http://identifiers.org/biomodels.db/MODEL1310110015#_f068860e_4e90_4a86_a003_782ac34c21fa
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:137872
is: Q8IWW8
is: SBO:0000252
name: ADHFE1

metaR RE1532M
kinetic law: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110015#

metaR RE0828E
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
name: RE0828
product: MODEL1310110015#

metaM strdnccoa c
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/47205473
is: SBO:0000247
initial amount: NaN
name: stearidonyl coenzyme A
is: C16163
constant: false
boundary condition: false
is: HMDB06519
initial concentration: 1.0

metaM glyclt c
initial concentration: 1.0
has only substance units: false
name: glycolate
is: CHEBI:29805
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00115
type: Species
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaM co e
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: carbon monoxide
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
is: CHEBI:17245
type: Species
boundary condition: false
initial concentration: 1.0

metaR S6T12g
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
product: MODEL1310110015#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_9b5f7bd2_58cb_4f7f_a6c6_f75ef55cd8c9
boundary condition: true
name: GALNT5
has only substance units: false
type: Species
is: A5PKZ1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11227
constant: false
initial amount: NaN

metaR AG13T17g
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d4e29690_4a76_41e2_86ce_3dd045f246ff
name: KHK
is: Q6IBK2
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3795
type: Species
is: SBO:0000252
has only substance units: false

metaM sarcs c
is: CHEBI:3513
is: C00213
initial concentration: 1.0
is: HMDB00271
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: Sarcosine
has only substance units: false
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110015#_142d5bf6_6ed3_496a_be6b_207d40682453
is encoded by: hsa:6185
name: RPN2
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: P04844

metaR GACMTRc
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
fast: false
name: guanidinoacetate N-methyltransferase (c)
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.2
reversible: true

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM hs l
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: heparan sulfate, free chain
is: CHEBI:28815
notes: FORMULA: C79H114N5O102S12 CHARGE: -13

metaR TCYNTt
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false

metaR r2389
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110015#
modifier: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
reversible: false

metaR r0885
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_112af703_1158_429e_bcb8_a21d088a9d34
has only substance units: false
is encoded by: hsa:10870
is: SBO:0000252
initial concentration: NaN
is: Q9UBK5
boundary condition: true
name: HCST
type: Species
initial amount: NaN
constant: false

metaM ksi pre25 g
type: Species
is: SBO:0000247
is: HMDB00175
is: C00130
is: CHEBI:58053
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 25
notes: FORMULA: C199H319N14O163S7X CHARGE: -8

metaR G13MT U
is version of: http://identifiers.org/ec-code/2.4.1.132
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_04e2c4c3_6653_44ea_bf81_6bc656c93cae
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: ASPA
is encoded by: hsa:443
is: Q6FH48
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2a5f5aee_7729_49b3_964f_376ffe8d08ff
is encoded by: hsa:23539
boundary condition: true
is: SBO:0000252
constant: false
is: O95907
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC16A8
type: Species

metaR NAt3 1
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
is described by: ECO:0000269
name: sodium proton antiporter (H:NA is 1:1)
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reversible: true
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_4d2078db_f2df_404c_aced_4935fd80aefe
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:AI924226
name: _AI924226_1_m
initial amount: NaN

metaM dolglcp U c
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
is: CHEBI:15812

metaR DRBK
is: SBO:0000176
name: Deoxyribokinase
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_600e505a_8a3e_440c_80fe_83897435c77b
name: ATP1A2
type: Species
is: P50993
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:477
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_4d1643f9_dc44_46ad_922a_437ecfdd306f
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q99714
boundary condition: true
constant: false
name: HSD17B10
is: SBO:0000252
is encoded by: hsa:3028

metaR S2L2N2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: false
name: s2l2n2m2masn transport, extracellular to lysosome
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
type: Reaction

metaM trdrd m
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
is: CHEBI:15967
has only substance units: false
name: Reduced thioredoxin
constant: false
is: SBO:0000247

metaM cspg a l
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB02183
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:36005
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_1999dc8e_dc11_4451_a7e1_f294eb989cc9
is: SBO:0000252
constant: false
is: P41247
type: Species
name: PNPLA4
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8228
boundary condition: true

metaM mescoa m
type: Species
is: CHEBI:27969
name: Mesaconyl-CoA
boundary condition: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
initial amount: NaN
is: C06028
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg34 l
is: CHEBI:16953
name: keratan sulfate I, degradation product 34
is: SBO:0000247
is: HMDB00812
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1

metaR AKGt4 3
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES:NCD
type: Reaction
modifier: MODEL1310110015#
name: AKG transport via sodium symport
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_4ced7317_855e_41e8_8b87_50c3f18a4956
is: O75387
is encoded by: hsa:8501
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC43A1
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_b75c103f_1531_4ffb_9923_034057cd9019
has only substance units: false
type: Species
is: Q9NPC4
is: SBO:0000252
is encoded by: hsa:53947
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: A4GALT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8df28e91_dd23_4ef5_a416_8b6e0e271537
is encoded by: hsa:2224
initial concentration: NaN
is: P14324
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: FDPS

http://identifiers.org/biomodels.db/MODEL1310110015#_4d49e579_f72c_426c_91aa_4d661f5b8548
initial concentration: NaN
constant: false
is: Q6ZWP6
is: SBO:0000252
name: ACAD8
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false
boundary condition: true
type: Species

metaR DOPASULT
reversible: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: Dopamine Sulfotransferase

metaM pmtcoa c
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
is: CHEBI:3454
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: HMDB01338
initial amount: NaN
is: C00154

metaR MALTSULtm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110015#
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110015#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_12cc4884_d6e4_4bca_8139_851e70c5f9b6
name: ALDH3B1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P43353
is encoded by: hsa:221
boundary condition: true
initial concentration: NaN

metaM pnto R c
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00210
is: SBO:0000247
initial concentration: 1.0
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_99c5f795_8169_4333_897c_ad14ddbbd08d
is encoded by: hsa:3417
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: O75874
constant: false
name: IDH1
is: SBO:0000252
type: Species

metaR DMNONCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction

metaR FAOXC164C143m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM cytd c
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
is: C00475
is: SBO:0000247
is: CHEBI:17562
boundary condition: false
is: HMDB00089
constant: false
initial amount: NaN
name: Cytidine

metaR GULLACter
reactant: MODEL1310110015#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110015#
is: SBO:0000185
name: gulonolactone endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110015#
fast: false

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_256438cf_e666_44c7_971a_07cfe13d0f30
type: Species
constant: false
is: Q86WU2
is: SBO:0000252
is encoded by: hsa:197257
has only substance units: false
boundary condition: true
initial amount: NaN
name: LDHD
initial concentration: NaN

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
is: CHEBI:58053
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
boundary condition: false
is: C00130
constant: false

metaM cs b l
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
is: HMDB02183
boundary condition: false
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
constant: false

metaR HXPRT
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM 5forthf c
is: HMDB01534
name: 5-Formiminotetrahydrofolate
is: C00664
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: CHEBI:57456
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6326514d_a926_4d4b_8675_49fe216a5659
name: _AI090874_1_c
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI090874
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM glyclt x
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00115
is: CHEBI:29805
name: glycolate
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial concentration: 1.0
type: Species

metaM glyald m
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
has only substance units: false
is: CHEBI:17378
is: HMDB01051
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
initial concentration: 1.0
boundary condition: false
constant: false

metaM pail45p hs m
is: CHEBI:28910
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
is: SBO:0000247
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b75d71b1_a2f9_4cfe_852a_6bc44914d767
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: GSTZ1

http://identifiers.org/biomodels.db/MODEL1310110015#_688bf4ae_87eb_48ed_ad12_5bec6187fcc6
is encoded by: hsa:111
name: ADCY5
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O95622

http://identifiers.org/biomodels.db/MODEL1310110015#_493cae89_625f_4aaa_a0b0_3788f7ad730e
constant: false
name: ATP1B3
initial concentration: NaN
type: Species
is: P54709
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:483
is: SBO:0000252

metaM pyam5p c
initial amount: NaN
is: HMDB01555
type: Species
is: CHEBI:58451
is: C00647
name: Pyridoxamine 5'-phosphate
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM strdnccoa m
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: C16163
boundary condition: false
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205473
is: HMDB06519

http://identifiers.org/biomodels.db/MODEL1310110015#_eafbf8bf_fa06_41e9_886a_11e61fed3f17
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: B7Z5G2
initial concentration: NaN
name: GBA
constant: false
is encoded by: hsa:2629

metaM tdchola x
has only substance units: false
boundary condition: false
constant: false
is: HMDB00951
name: taurochenodeoxycholate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
initial amount: NaN

metaM ppbng c
constant: false
boundary condition: false
type: Species
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial concentration: 1.0
is: CHEBI:58126
has only substance units: false
is: HMDB00245
is: C00931
name: Porphobilinogen
initial amount: NaN
is: SBO:0000247

metaR THYOXt
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
name: T4 transport via bicarbonate countertransport

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47

metaR r1897
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: false
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_09378121_7855_48cf_8e51_524dd984ecba
is: SBO:0000252
initial amount: NaN
constant: false
name: HSD11B2
is encoded by: hsa:3291
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P80365

metaM pail45p hs n
constant: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
initial concentration: 1.0
type: Species
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
boundary condition: false
is: CHEBI:28910

metaR RE1796M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
fast: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
name: RE1796
kinetic law: MODEL1310110015#

metaR SO4tl
type: Reaction
name: Sulfate transport (lysosome)
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_9ad8db33_7e85_4750_b8bf_a9949eb354ed
type: Species
constant: false
is encoded by: hsa:2582
initial amount: NaN
is: Q14376
initial concentration: NaN
has only substance units: false
name: GALE
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_b4b176fc_feb1_44c9_a153_3a034fcf79d4
has only substance units: false
initial amount: NaN
name: ALPPL2
is encoded by: hsa:251
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: P10696
initial concentration: NaN

metaM cytd e
is: C00475
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
has only substance units: false
is: HMDB00089
name: Cytidine

http://identifiers.org/biomodels.db/MODEL1310110015#_72974d17_98e3_4f3e_ad98_4e62bc5acfb8
name: DGKE
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8526
initial concentration: NaN
is: A1L4Q0

metaM dhcrm hs c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
has only substance units: false
type: Species
name: dihydroceramide
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5ffe8e4d_bfd9_41b2_a705_89c3b0016f8d
type: Species
is: Q9BRC7
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84812
is: SBO:0000252
has only substance units: false
name: PLCD4
constant: false
initial amount: NaN

metaM acngalgbside hs g
type: Species
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: CHEBI:16523
initial amount: NaN
name: sialyl galactosylgloboside
is: HMDB03406
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_fc39d8c6_5e48_4daf_aaa2_f366addee6a1
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10587
type: Species
name: TXNRD2

metaM CE0693 m
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: 3-oxolaur-6-cis-enoyl-CoA
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0
boundary condition: false
is: HMDB11123
is: CHEBI:28387

metaR BTND1n
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
name: biotinidase (biotin), nuclear
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR NDP8ex
type: Reaction
is: SBO:0000176
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
name: nucleoside-diphosphatase (UTP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false

metaR LNLNCGt
fast: false
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: fatty acid transport via diffusion
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_5ac02432_23db_4c75_9ecd_1feb10407d1c
is encoded by: hsa:6675
boundary condition: true
has only substance units: false
type: Species
name: UAP1
is: Q16222
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR AKGMALtm
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
name: alpha-ketoglutarate/malate transporter
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
fast: false
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_ca2c7271_e7e6_49ec_8a00_311ca32f3ffb
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:205
boundary condition: true
name: AK4
type: Species
has only substance units: false
initial amount: NaN

metaR PRGSTRNt
is: SBO:0000185
name: Progesterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110015#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR FAS100COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
name: fatty acyl-CoA synthase (n-C10:0CoA)
fast: false

metaR ASNNm
is described by: ECO:0000254
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
fast: false
modifier: MODEL1310110015#
is: SBO:0000176
name: L-asparaginase (mitochondrial)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.1
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaM nadph r
type: Species
has only substance units: false
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
is: HMDB00221
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
initial concentration: 1.0
initial amount: NaN
constant: false

metaM trdrd c
constant: false
name: Reduced thioredoxin
is: CHEBI:15967
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
is: C00342

http://identifiers.org/biomodels.db/MODEL1310110015#_d47f5b43_b7eb_4095_bbea_7578f0f91807
name: GALNTL2
initial amount: NaN
is encoded by: hsa:117248
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q8N3T1
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_53d313eb_a658_4b95_b354_55dc2f5e0104
has only substance units: false
name: ACAA2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:10449
initial amount: NaN
is: P42765

metaM HC00319 m
initial concentration: 1.0
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
type: Species
is: CHEBI:30794
name: Malonate
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM ksi pre2 g
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0
type: Species
is: C00130
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 2

http://identifiers.org/biomodels.db/MODEL1310110015#_da39447f_1ac7_4d72_a35d_d2f077a50bf2
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9BY49
is encoded by: hsa:55825
constant: false
has only substance units: false
boundary condition: true
name: PECR
initial amount: NaN

metaR 2HBt2
type: Reaction
modifier: MODEL1310110015#
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110015#
reversible: true

metaM undcoa m
is: HMDB13114
boundary condition: false
name: undecanoylcoa
initial concentration: 1.0
constant: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_6f6c1bc9_e0a0_44c5_8e6c_b55a4729776d
has only substance units: false
type: Species
constant: false
is: Q96E98
name: RHAG
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6005

http://identifiers.org/biomodels.db/MODEL1310110015#_25747d49_2ef3_41b7_afa8_3694d9f2ee07
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6487
has only substance units: false
initial concentration: NaN
name: ST3GAL3
constant: false
boundary condition: true

metaM pmtcoa m
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57379
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
is: HMDB01338

metaR r0779
is: SBO:0000176
modifier: MODEL1310110015#
reversible: false
product: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM fol c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00121
has only substance units: false
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
initial concentration: 1.0

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR EX dca LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Decanoate (n-C10:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b8b6bdfd_f238_4c33_8f3b_662ca9858840
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229
boundary condition: true
type: Species
is: SBO:0000252
is: Q9NVE7
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_e26e4596_0b5f_42e0_8558_1a625cf621a9
constant: false
name: _83530_1_c
type: Species
boundary condition: true
is encoded by: hsa:83530
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r2380
fast: false
is: SBO:0000185
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#

metaM mmcoa R m
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: (R)-methylmalonyl-CoA(5-)
initial amount: NaN
is: CHEBI:57326
initial concentration: 1.0
is: HMDB01269
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3206a213_9f10_4452_806b_83432016ac9b
is: SBO:0000252
is: P55809
boundary condition: true
is encoded by: hsa:5019
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: OXCT1

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00725

metaR SPHS1Pte
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reversible: true
name: sphingosine-1-phosphate transport
is: SBO:0000185
fast: false
product: MODEL1310110015#

metaR PNTEH
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
product: MODEL1310110015#
name: Hydrolase Class ( RXN R02973)
is: SBO:0000176
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.1.92

metaR r1898
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110015#
type: Reaction

metaR r1257
name: EC:6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: false
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_3e187cda_4d22_40da_8dfc_7e0e7a6d9bb8
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2745
is: SBO:0000252
name: GLRX
constant: false
is: P35754
has only substance units: false

metaM fol e
is: HMDB00121
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_9ac0927c_dda6_4dcd_b693_701ab18a5bbb
has only substance units: false
is: Q9H490
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIGU
constant: false
is encoded by: hsa:128869
type: Species
is: SBO:0000252

metaR FUCASEe
product: MODEL1310110015#
fast: false
name: alpha-fucosidase, extracellular
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR r1899
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110015#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110015#

metaR DOPAt4 2 r
product: MODEL1310110015#
type: Reaction
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM acgpail hs c
initial concentration: 1.0
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
type: Species
initial amount: NaN
is: CHEBI:57265
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR TRDRm
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
is: SBO:0000176

metaR RE0690E
name: RE0690
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
reversible: false
is: SBO:0000176

metaM 4hpro LT c
is: CHEBI:18095
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
name: trans-4-hydroxy-L-proline
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00725

metaM q10 m
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:46245
is: HMDB01072
boundary condition: false

metaR PYAM5POr
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
name: pyridoxamine 5'-phosphate oxidase
type: Reaction
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
is: SBO:0000176
reactant: MODEL1310110015#

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
constant: false
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
initial concentration: 1.0
is: HMDB01338
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaR PTPATe
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
type: Reaction
name: PTPATe
fast: false
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0cf2b78e_1c43_4806_a64d_b39b950311f9
is: SBO:0000252
name: GBA
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: B7Z5G2
type: Species
is encoded by: hsa:2629

metaM cytd m
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: cytidine
initial concentration: 1.0
is: HMDB00089
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

http://identifiers.org/biomodels.db/MODEL1310110015#_a029d5f2_4a08_4629_8672_b7264cc4ceee
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23439
initial amount: NaN
is: Q9UN42
is: SBO:0000252
name: ATP1B4
type: Species
has only substance units: false

metaR CITt4 4
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction
product: MODEL1310110015#
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
name: citrate transport via sodium symport
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#

metaR GCCam
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
type: Reaction
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110015#_621c48a5_ac00_4ce1_8a3d_f9eb228700d1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8706
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: O75752
name: B3GALNT1

metaR FACOAL244 1
reactant: MODEL1310110015#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000

metaM hdd2coa x
has only substance units: false
is: CHEBI:61526
initial amount: NaN
is: SBO:0000247
is: HMDB03945
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272

metaM lpchol hs c
name: lysophosphatidylcholine
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM pnto R e
boundary condition: false
is: HMDB00210
is: SBO:0000247
is: CHEBI:7916
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
name: (R)-Pantothenate
initial concentration: 1.0

metaR DOLPMT3 Uer
kinetic law: MODEL1310110015#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.260
fast: false
reactant: MODEL1310110015#

metaR GND
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5226.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:8978909 NOTES:SMP Note no proton generation by the the reaction
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
name: phosphogluconate dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.44
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a7314853_f606_450d_9f48_b25cf3cfa8b0
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4512
name: COX1
boundary condition: true
is: Q7GXY8

metaR DINt
is described by: ECO:0000000
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
name: deoxyinosine transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110015#_32741785_033b_4653_a418_ea4f34a21235
is: Q9UHI7
is encoded by: hsa:9963
name: SLC23A1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM ksii core4 deg4 l
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C66H108N6O48SX CHARGE: -1
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 4
type: Species
is: CHEBI:16953
is: SBO:0000247
is: HMDB00812
boundary condition: false

metaR r0774
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110015#
reactant: MODEL1310110015#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_00cf3d08_8e6b_4c11_89cf_ad4a531546a4
is encoded by: hsa:57665
is: Q9HBH5
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: RDH14
initial amount: NaN
type: Species
constant: false

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR CITt4 2
product: MODEL1310110015#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110015#
name: citrate transport via sodium symport
is described by: ECO:0000269
modifier: MODEL1310110015#
is: SBO:0000185
fast: false
reactant: MODEL1310110015#

metaR ACALDt
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
name: acetaldehyde reversible transport

http://identifiers.org/biomodels.db/MODEL1310110015#_a9b8eec3_b2aa_482a_9be3_06e0eedcd5a4
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM lpchol hs e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:60479
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
name: lysophosphatidylcholine

http://identifiers.org/biomodels.db/MODEL1310110015#_d50f8187_1200_4ee6_bd3d_b6f8776b1082
is: SBO:0000252
is: Q9BYC2
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:64064
initial concentration: NaN
has only substance units: false
name: OXCT2

metaM gdpmann c
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
has only substance units: false
is: CHEBI:57527
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
boundary condition: false
initial concentration: 1.0
is: HMDB01163
is: SBO:0000247
type: Species

metaR ORPT
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
is described by: ECO:0000269
reversible: true
name: orotate phosphoribosyltransferase
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10

http://identifiers.org/biomodels.db/MODEL1310110015#_714ceea1_e1fb_4866_891e_29c51ccd4bbe
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P00915
name: CA1
is encoded by: hsa:759

metaR KSII CORE4t
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
type: Reaction

metaR RTOTAL3FATPc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaR KSII CORE2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000

metaM pail45p hs c
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
is: CHEBI:28910
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaR AMETtd
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-methionine

metaR VLCSp
modifier: MODEL1310110015#
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
kinetic law: MODEL1310110015#
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110015#

metaM ctdecdcoa m
is: HMDB00792
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: cis2trans4decadienoylcoa
boundary condition: false
is: C08277
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_aba3329e_7e0a_4c7e_8086_a879368e6a3e
is encoded by: hsa:771
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CA12
type: Species

metaR AMPDA
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
product: MODEL1310110015#
name: Adenosine monophosphate deaminase
type: Reaction
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.6
reversible: false
is: SBO:0000176

metaR FORtr
is: SBO:0000185
name: FOR transporter, endoplasmic reticulum
fast: false
reversible: true
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_962ff740_d0ba_4e83_b139_a0c03ffa5777
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2720
is: P16278
boundary condition: true
name: GLB1
has only substance units: false
constant: false

metaR r0915
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110015#

metaR SUCCt2m
is described by: ECO:0000269
reversible: true
name: succinate transport, mitochondrial
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_713076c5_c2d7_4dc1_9ed8_751d2616c723
boundary condition: true
type: Species
is: Q5JQ10
initial amount: NaN
is encoded by: hsa:132
is: SBO:0000252
has only substance units: false
name: ADK
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_451e062a_074e_4baf_a77c_76bc2b652bae
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ADCY6
type: Species
is: O43306
is encoded by: hsa:112
has only substance units: false
constant: false

metaR G6PDH2rer
is: SBO:0000176
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_38f8d55f_d654_4087_8313_c0b7b91e8d05
is: SBO:0000252
name: ACHE
constant: false
initial amount: NaN
is encoded by: hsa:43
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM dece4coa m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
name: 4-decenoylcoa
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02145

metaM dcholcoa r
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
initial concentration: 1.0
type: Species
boundary condition: false
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: HMDB06292
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_210cbdcd_1384_418b_8663_07a45c445ba1
name: PFKM
boundary condition: true
type: Species
constant: false
is: P08237
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5213
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2fcc395e_1ede_444b_b341_8d9ada92c35e
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ST3GAL3
constant: false
initial concentration: NaN
type: Species
is: Q96L53
is encoded by: hsa:6487

metaR RE1533M
product: MODEL1310110015#
name: RE1533
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM sebcoa c
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: C14143
is: HMDB04047
type: Species
name: sebacoylcoa
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247
initial amount: NaN

metaM lneldc e
name: linoelaidic acid (all trans C18:2)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06270
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+

metaR BIOCYTtn
is: SBO:0000185
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110015#
name: biocytin transport, nuclear
product: MODEL1310110015#
type: Reaction
reversible: true

metaM ala D e
is: HMDB01310
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
initial concentration: 1.0
name: D-alanine
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15570
boundary condition: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_53d56283_3123_4017_8154_25b31c32cba5
initial amount: NaN
name: IDI1
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q13907
constant: false
is encoded by: hsa:3422
has only substance units: false

metaR r0917
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

metaR UMPK
name: UMP kinase
product: MODEL1310110015#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#

metaM tethex3coa c
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: HMDB06243
constant: false
initial amount: NaN
is: C16168
name: tetracosahexaenoyl coenzyme A
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cd0b8834_54a8_4f06_8a24_4b7aaa2ea674
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6582
constant: false
has only substance units: false
name: SLC22A2

metaM 3ddecdicoa m
is: SBO:0000247
is: C05280
initial amount: NaN
constant: false
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3,6-dodecadienoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a2f15527_1e27_45eb_bcc9_0cc565677f23
type: Species
is encoded by: hsa:4701
has only substance units: false
name: NDUFA7
is: SBO:0000252
boundary condition: true
constant: false
is: Q6FG42
initial amount: NaN
initial concentration: NaN

metaM HC00319 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
initial concentration: 1.0
name: Malonate
constant: false
has only substance units: false
type: Species

metaM creat e
is: CHEBI:16919
is: HMDB00064
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_642e8590_e03d_4544_860c_80671709f717
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: RDH5
constant: false
initial concentration: NaN
has only substance units: false
is: Q92781
is encoded by: hsa:5959

metaR CBR2
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
name: Carbonyl reductase [NADPH] 1
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.189
reversible: false

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM lnlccoa r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
has only substance units: false
type: Species
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
constant: false
initial amount: NaN
boundary condition: false

metaM hs deg11 l
initial concentration: 1.0
name: heparan sulfate, degradation product 11
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00868
is: CHEBI:57737
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110015#_782f6bcf_fc3e_4f0f_9497_7434785f0b32
has only substance units: false
constant: false
boundary condition: true
name: PEMT
type: Species
is: SBO:0000252
is encoded by: hsa:10400
is: Q9UBM1
initial amount: NaN
initial concentration: NaN

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM vacc c
is: C08367
type: Species
is: CHEBI:30828
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: trans-vaccenate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_648908f7_4b4a_4b5e_b4ec_5410deeb00ae
name: BCAT2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O15382
type: Species
boundary condition: true
constant: false
is encoded by: hsa:587
has only substance units: false

metaR NTP3e
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110015#
fast: false
reversible: false
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176
name: nucleoside-triphosphatase (GTP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6

http://identifiers.org/biomodels.db/MODEL1310110015#_0a01f9c3_2fe8_4bcb_97ad_e47cd7f8c8f3
type: Species
is encoded by: hsa:5211
is: SBO:0000252
initial amount: NaN
is: P17858
constant: false
name: PFKL
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_7522b86e_46f7_480b_8936_682aa712b682
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51022
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: GLRX2

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
type: Reaction
reversible: false
product: MODEL1310110015#

metaR CYTK7n
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP,UTP),nuclear
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true

metaM ala D c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
initial concentration: 1.0
name: D-alanine
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:15570

http://identifiers.org/biomodels.db/MODEL1310110015#_9a09520b_9ca2_4fb5_9f47_9839db25b4f9
is encoded by: hsa:U37519
has only substance units: false
initial concentration: NaN
name: _U37519_1_e
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM 3octdectecoa m
name: 3,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110015#_7cb95128_56f1_44fb_a0d4_bc81713b0e6b
boundary condition: true
has only substance units: false
name: TMEM54
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:113452
constant: false
is: Q969K7
is: SBO:0000252

metaM g3m8mpdol U r
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
constant: false
is: C05873
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_7d6ad3ad_f66e_4fa9_bdca_6d395bcea0e9
is encoded by: hsa:T83654
constant: false
initial amount: NaN
initial concentration: NaN
name: _T83654_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR L LACt4r
type: Reaction
name: L-lactate reversible transport via sodium symport
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:

metaR r0911
name: Facilitated diffusion
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185

metaM udpgal g
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00302
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
is: CHEBI:58439
initial concentration: 1.0
name: UDP-D-galactose(2-)
type: Species

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_6791f3ac_1dd3_45c5_a58b_e50681ef3c91
constant: false
has only substance units: false
type: Species
is encoded by: hsa:124
initial amount: NaN
is: P07327
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ADH1A

metaR AG13T9g
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_91bdd251_19e3_4f0c_8614_06e1406220dd
is: O95477
type: Species
boundary condition: true
name: ABCA1
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:19
is: SBO:0000252
has only substance units: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR r2393
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_6c47dd02_c100_4969_965a_011fde6ecd85
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:5151
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: PDE8A

metaR PEt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: phosphatidylethanolamine transport

http://identifiers.org/biomodels.db/MODEL1310110015#_edd26b40_c56d_43ba_a59c_62f179bbdc99
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM c226coa m
initial concentration: 1.0
boundary condition: false
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
name: cervonyl coenzyme A
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false

metaM vacc e
name: trans-vaccenate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:30828
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00283
name: D-ribose
is: CHEBI:16988
initial amount: NaN

metaM galgluside hs c
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: HMDB06535
has only substance units: false
name: galactosyl glucosyl ceramide

http://identifiers.org/biomodels.db/MODEL1310110015#_d17b20f1_fa89_4f48_8b9f_bd4dbedfd913
is encoded by: hsa:85365
constant: false
name: ALG2
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9H553
initial amount: NaN

metaR DESAT22 1p
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8ddcf543_308e_436f_bda9_20fd2a7e27ec
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI934540
constant: false
name: _AI934540_1_c
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR NODe
reversible: true
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110015#
name: NODe
is: SBO:0000185
is described by: ECO:0000134

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_cec7d3b5_25d0_4dc3_adc0_b0758d7a2497
has only substance units: false
boundary condition: true
is: E9PAY8
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: PPAP2C
is: SBO:0000252
is encoded by: hsa:8612

metaR r0913
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110015#

metaR FAS160COA
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110015#
is described by: ECO:0000269
fast: false

metaM gal1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58336
initial amount: NaN
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
initial concentration: 1.0
boundary condition: false
is: HMDB00645

http://identifiers.org/biomodels.db/MODEL1310110015#_6449c775_b2d3_4f53_ac75_3f36a22dd3d1
type: Species
boundary condition: true
name: MCCC2
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:64087
is: Q9HCC0
initial concentration: NaN

metaR NCAMUP
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
product: MODEL1310110015#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Nicotinamide acid uptake
fast: false

metaM dcholcoa x
boundary condition: false
name: chenodeoxycholoyl coenzyme a
constant: false
has only substance units: false
is: HMDB06292
is: CHEBI:28701
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

http://identifiers.org/biomodels.db/MODEL1310110015#_768e0adf_003a_4b4a_9ee8_9f4524479ed4
constant: false
boundary condition: true
has only substance units: false
name: AGPAT3
type: Species
initial concentration: NaN
is encoded by: hsa:56894
is: SBO:0000252
initial amount: NaN

metaM CE5119 m
initial amount: NaN
constant: false
is: CHEBI:57923
name: trans-3-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
type: Species

metaM fad m
is: SBO:0000247
type: Species
initial amount: NaN
is: C00016
constant: false
is: CHEBI:16238
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248

http://identifiers.org/biomodels.db/MODEL1310110015#_9b769a8f_fc25_475d_847c_a1f7345bf0ed
boundary condition: true
type: Species
is encoded by: hsa:1644
constant: false
is: Q53Y41
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DDC

http://identifiers.org/biomodels.db/MODEL1310110015#_35990a0b_d509_4c08_a56b_59f7ed3edddd
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P00390
constant: false
has only substance units: false
name: GSR
is encoded by: hsa:2936
type: Species
boundary condition: true

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c82e0a56_6830_4826_b6da_2ff03268778e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NDUFS8
type: Species
is encoded by: hsa:4728
is: O00217
has only substance units: false
boundary condition: true
constant: false

metaM lnlccoa m
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial amount: NaN
is: HMDB01064
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110015#_0ddd5e5a_3e5c_4dd5_8628_149187c8a3f5
is encoded by: hsa:80271
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ITPKC
is: Q96DU7
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR SCP21cx
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_bf9c1837_e002_4cde_b310_e1dac3a5a0a4
is: SBO:0000252
name: ABAT
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:18
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_d1cb01a6_3e3f_434e_a1af_63a77bd460e3
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PIGO
is encoded by: hsa:84720
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_0f0b91b1_66df_42b0_afb0_89da69083272
has only substance units: false
is: P49753
is encoded by: hsa:10965
name: ACOT2
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7c63a889_ba6b_47df_af11_f166a52f2f6b
has part: B3KT19
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5291
name: PIK3CB:PIK3R1
type: Species
has only substance units: false
constant: false
has part: B4DER4
is: SBO:0000297
is encoded by: hsa:5295

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR RE2649C
product: MODEL1310110015#
name: RE2649
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaR GTHRDtr
name: glutathione transport via diffusion
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
fast: false
is: SBO:0000185
product: MODEL1310110015#

metaR O2tp
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
name: O2 transport, peroxisomal
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_ca507826_a839_4218_8fa9_af3d3cbb0242
constant: false
is encoded by: hsa:NM 001929
name: _NM_001929_1_c
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM CE0713 m
is: HMDB02329
initial amount: NaN
type: Species
name: 3-oxolinoleoyl-CoA
has only substance units: false
is: CHEBI:30623
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_a0d4a63f_266a_4cef_9253_cfe484ab9fb8
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:226
name: ALDOA

http://identifiers.org/biomodels.db/MODEL1310110015#_30db5d72_d89f_4e20_934d_dbc092922db2
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: NDUFA4
is: SBO:0000252
is encoded by: hsa:4697
is: O00483

metaM glu5sa m
is: SBO:0000247
is: C01165
constant: false
name: L-Glutamate 5-semialdehyde
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
initial concentration: 1.0
is: CHEBI:17232
has only substance units: false
initial amount: NaN
is: HMDB02104
boundary condition: false

metaM ksi pre5 g
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 5
notes: FORMULA: C101H164N7O75SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110015#_d1a11fcb_8923_4169_9829_88fbf4c6bdd1
initial concentration: NaN
constant: false
name: NAGA
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4668
is: P17050

metaR FAOXC8C6m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR 5MTHFt2le
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110015#
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
product: MODEL1310110015#

metaR GLUPROASCT1
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reversible: false
type: Reaction
name: glutamate intake by system ASCT-1 transporter
fast: false
modifier: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000134

metaR FACOAL2042
reversible: true
name: fatty-acid--CoA ligase
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_f1462531_7b3c_416d_8a21_081d76db5642
is: O75355
is encoded by: hsa:956
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: ENTPD3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cbf8d90a_6c1b_4b3e_be83_d74e81645d6d
is: SBO:0000252
type: Species
is encoded by: hsa:522
constant: false
name: ATP5J
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_17e0ebb7_5a50_45af_ac93_982b58905b85
type: Species
is: SBO:0000252
name: ACO2
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:50
is: Q99798
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d317a165_46a8_499c_81d8_f4ddef7d1c1b
is: A8K8P8
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2530
type: Species
name: FUT8
has only substance units: false
boundary condition: true

metaR GALASE9ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110015#
name: beta-galactosidase, lysosomal
type: Reaction

metaM ha deg1 l
boundary condition: false
is: CHEBI:16336
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: hyaluronan degradation product 1
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110015#_7981b289_dbc1_4ab4_b2d4_86362cb7684e
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: HEXB
type: Species
is encoded by: hsa:3074
has only substance units: false
constant: false
is: P07686
initial amount: NaN

metaR O2tn
fast: false
kinetic law: MODEL1310110015#
name: O2 nuclear transport
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_c0e8d120_3019_4036_bdc9_36e5de36e693
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _AL050025_1_c
initial amount: NaN
is encoded by: hsa:AL050025

metaM od2coa c
boundary condition: false
is: C16218
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: SBO:0000247
is: HMDB06529
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:50570
name: trans-Octadec-2-enoyl-CoA
type: Species

metaR DASCBR
kinetic law: MODEL1310110015#
name: dehydroascorbate reductase
product: MODEL1310110015#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.4.1
fast: false
is described by: ECO:0000269
modifier: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_2d124d19_99ef_43e4_8fe9_d21b297425e0
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:284273
name: ZADH2
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8N4Q0

metaM cspg a e
constant: false
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
is: HMDB00300
type: Species
is: CHEBI:17568
is: C00106
initial amount: NaN
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: SBO:0000247

metaR C3STDH1Pr
reversible: false
is: SBO:0000176
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e09858bd_3ec2_473f_b84f_01b001183010
is encoded by: hsa:6470
constant: false
type: Species
has only substance units: false
name: SHMT1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_05842033_f372_42dc_ba2a_3f0cd3a44e1e
is: O95992
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CH25H
is encoded by: hsa:9023
boundary condition: true

metaR MANtg
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: mannose efflux from Golgi apparatus
reactant: MODEL1310110015#
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaM dtdp n
is: CHEBI:58369
initial amount: NaN
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
is: HMDB01274
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_be13be60_b957_42f0_9f3d_035d655d47d8
boundary condition: true
name: MDH1
is: SBO:0000252
has only substance units: false
is: B7Z3I7
type: Species
initial amount: NaN
is encoded by: hsa:4190
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_157fc017_a289_4a31_865d_f29471735c87
type: Species
initial concentration: NaN
name: _D29675_1_e
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:D29675

http://identifiers.org/biomodels.db/MODEL1310110015#_772c218c_bf8e_466b_8477_2917ef72f74c
constant: false
boundary condition: true
is encoded by: hsa:728441
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: GGT2
has only substance units: false

metaR FUMSO3tm
is: SBO:0000185
product: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

metaR G14T17g
type: Reaction
fast: false
modifier: MODEL1310110015#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR HPDCAt
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
name: fatty acid transport via diffusion
reversible: true

metaR LGTHL
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.4.1.5
is: SBO:0000176
modifier: MODEL1310110015#
name: lactoylglutathione lyase
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is described by: ECO:0000269
product: MODEL1310110015#

metaR NADtpu
reactant: MODEL1310110015#
name: NAD transporter, peroxisome
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
type: Reaction
kinetic law: MODEL1310110015#

metaR r1803
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
type: Reaction

metaR THP2Ctp
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reactant: MODEL1310110015#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false
product: MODEL1310110015#

metaM urcan c
initial amount: NaN
is: HMDB00301
boundary condition: false
name: Urocanate
is: CHEBI:17771
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_1896ceca_02da_4b57_8bfa_3a482c91a557
is encoded by: hsa:8836
initial amount: NaN
boundary condition: true
is: Q92820
has only substance units: false
type: Species
initial concentration: NaN
name: GGH
is: SBO:0000252
constant: false

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM creat c
initial amount: NaN
is: CHEBI:16919
name: creatine
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: HMDB00064

metaR GMPR
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.7.1.7
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: GMP reductase
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
reversible: false
product: MODEL1310110015#
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR H2Oter
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true
fast: false

metaR S6T13g
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reversible: false
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#

metaM 2hexdtricoa m
is: HMDB02288
initial concentration: 1.0
is: SBO:0000247
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_fc06e3a9_aeb7_42bd_969e_8513da035102
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PLCXD2
initial amount: NaN
initial concentration: NaN
is: Q0VAA5
is encoded by: hsa:257068

metaM fuc1p L c
is: CHEBI:28319
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
boundary condition: false
name: L-Fucose 1-phosphate
is: SBO:0000247
is: HMDB01265
initial amount: NaN

metaR ADCim
product: MODEL1310110015#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
fast: false

metaR AG13T16g
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR MI1PP
reactant: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
type: Reaction
name: myo-inositol 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is: SBO:0000176

metaM dtdp m
constant: false
is: C00363
name: dTDP
initial concentration: 1.0
initial amount: NaN
is: HMDB01274
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cd2c245b_73df_455e_904c_7b9293e06eb8
is encoded by: hsa:80025
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: PANK2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_783bd7b7_8be8_407e_a50f_fd39d7776d10
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q8IXK2
name: GALNT12
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:79695

http://identifiers.org/biomodels.db/MODEL1310110015#_58806ace_858b_4638_be7d_e0d87ff93094
type: Species
is encoded by: hsa:427
is: Q96AS2
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ASAH1

metaR PFK
is: SBO:0000176
reactant: MODEL1310110015#
name: phosphofructokinase
kinetic law: MODEL1310110015#
type: Reaction
fast: false
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.11
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR ATPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#
is: SBO:0000185
type: Reaction
fast: false
name: ATP transporter, peroxisomal

metaR RE0512M
name: RE0512
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
type: Reaction
is: SBO:0000176

metaR r2507
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR O2t
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
fast: false
name: o2 transport (diffusion)
product: MODEL1310110015#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_b294bb16_7683_4d92_8dd2_3fe57b670df2
name: B3GALT5
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9Y2C3
type: Species
is encoded by: hsa:10317

metaR DESAT18 10
reactant: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
is described by: ECO:0000000
reversible: false
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_00982cd1_12c4_4960_9214_cfee92d8a988
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:8611
name: PPAP2A
is: G3XA95
constant: false
has only substance units: false

metaR TMNDNCt
fast: false
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_3d331a14_e453_4d8a_af3f_7997d7e4f34c
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI291895
constant: false
name: _AI291895_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_c22e49b5_1f96_4785_9577_b2420d05aced
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: SLC25A10
is: SBO:0000252
is encoded by: hsa:1468
boundary condition: true
is: Q9UBX3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_48237650_1bc3_45da_afda_9e52e2aa467c
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9UJ70
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NAGK
is encoded by: hsa:55577

metaM lnlccoa c
has only substance units: false
initial concentration: 1.0
name: linoleic coenzyme A
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
is: HMDB01064
constant: false
is: http://identifiers.org/pubchem.compound/5462164

http://identifiers.org/biomodels.db/MODEL1310110015#_27910f31_7f6d_4324_aa35_02da77f7a2e0
is: SBO:0000252
name: SLC46A1
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q96NT5
is encoded by: hsa:113235
initial concentration: NaN
boundary condition: true

metaR GUAt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
product: MODEL1310110015#
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
name: Guanine transport

metaM ksi deg4 l
type: Species
is: HMDB00868
has only substance units: false
is: CHEBI:57737
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 4
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
boundary condition: false
constant: false
initial concentration: 1.0

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaM forglu c
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: CHEBI:18327
boundary condition: false
initial amount: NaN
name: N-Formimidoyl-L-glutamate
is: HMDB00854
is: SBO:0000247
is: C00439

metaM fum m
is: CHEBI:29806
name: Fumarate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
type: Species
boundary condition: false
is: HMDB00134

metaR r2508
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
fast: false
reversible: true
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000

metaR FACOAL160i
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: C160 fatty acid activation
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR GLCAASE7ly
fast: false
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110015#

metaR r0781
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110015#_4bfb676d_e00e_40d5_a5e2_8b1b5f80b495
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: CHKA
type: Species
initial concentration: NaN
is encoded by: hsa:1119
is: SBO:0000252

metaR GTHOm
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
product: MODEL1310110015#
type: Reaction
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6d9e96c9_4061_4ac8_bd04_32f1ff101eca
is: P48200
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3658
boundary condition: true
has only substance units: false
name: IREB2
type: Species

metaR S6T14g
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110015#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_6a61897b_1625_4058_a36a_af46f1263f0b
is: SBO:0000252
has only substance units: false
is: P23634
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:493
name: ATP2B4
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_0e23e039_d62e_4bea_821b_564e2ca16d89
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: ADCY8
is: Q4F7X0
is encoded by: hsa:114
is: SBO:0000252

metaR r2509
reversible: true
reactant: MODEL1310110015#
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_60707d08_f8cd_4487_abe0_34a5207ef2fc
initial amount: NaN
name: PPT1
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5538
initial concentration: NaN
boundary condition: true
is: Q6FGQ4
type: Species

metaM ksi deg25 l
has only substance units: false
type: Species
is: CHEBI:16953
is: HMDB00812
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 25
constant: false
boundary condition: false
is: SBO:0000247

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r0784
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

http://identifiers.org/biomodels.db/MODEL1310110015#_cc41ec24_d6f0_44dd_b611_2038ff48ca15
is: SBO:0000252
is encoded by: hsa:2739
initial concentration: NaN
constant: false
is: Q04760
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: GLO1

metaR N2M2NMASNtly
reactant: MODEL1310110015#
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM dcholcoa c
initial amount: NaN
is: CHEBI:28701
type: Species
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
name: chenodeoxycholoyl coenzyme a
has only substance units: false
constant: false
is: HMDB06292
is: SBO:0000247

metaR GLXtm
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
name: glyoxylate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110015#_4f9ce113_cb85_4451_91e7_448e3ad72a8f
initial amount: NaN
type: Species
is: Q9NUD9
is encoded by: hsa:55650
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PIGV
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5996507c_761f_4ec8_8e97_676ccee9d39f
is: SBO:0000252
initial concentration: NaN
is: O14772
initial amount: NaN
is encoded by: hsa:8790
type: Species
has only substance units: false
boundary condition: true
name: FPGT
constant: false

metaR G14T18g
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110015#
type: Reaction

metaR PMANM
is version of: http://identifiers.org/ec-code/5.4.2.8
product: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphomannomutase
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_7e04ede5_4fde_4f6b_b0c8_e5d9d4cd4919
name: SLC4A8
boundary condition: true
is: E7EML0
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:9498
is: SBO:0000252
type: Species

metaR r1262
type: Reaction
fast: false
product: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR MG1er
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
modifier: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110015#

metaR r0783
reactant: MODEL1310110015#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM ppcoa m
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
type: Species
constant: false
is: C00100
boundary condition: false
name: Propanoyl-CoA
initial concentration: 1.0
is: CHEBI:57392
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_e2f3077b_c3db_4bfb_8a8b_3d2c55df3ee4
name: ST3GAL3
is encoded by: hsa:6487
is: B4DX62
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR RPE
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
name: ribulose 5-phosphate 3-epimerase
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

metaM bhb c
name: (R)-3-hydroxybutyrate
constant: false
is: CHEBI:10983
has only substance units: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
boundary condition: false
is: HMDB00011
initial amount: NaN
initial concentration: 1.0

metaR CSNAT2m
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
fast: false

metaR O2tm
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
name: O2 transport (diffusion)
reversible: true
fast: false
is: SBO:0000185

metaR RTOTAL2t
reactant: MODEL1310110015#
name: RTOTAL2 transport
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_5a0388ee_0a2d_41fa_b34c_54d0aad34e01
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:222
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH3B2
is: P48448

http://identifiers.org/biomodels.db/MODEL1310110015#_49b083b8_cc5c_4389_9a24_5c65a2766cef
constant: false
is encoded by: hsa:29880
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q9Y673
name: ALG5
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_33dbd399_9b94_4cda_9247_a29bd8d4561f
type: Species
name: PIPOX
has only substance units: false
is: Q9P0Z9
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:51268
initial concentration: NaN

metaR r0899
is described by: ECO:0000000
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#

metaR r0309
is version of: http://identifiers.org/ec-code/1.4.3.22
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_65b92fa0_2380_4bd5_ae68_ec3ca80ba061
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:122970
boundary condition: true
is: Q8N9L9
initial concentration: NaN
constant: false
name: ACOT4

metaR r1996
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5d3b94da_a9f2_408e_bb3a_08179c67f799
constant: false
boundary condition: true
is encoded by: hsa:84076
is: SBO:0000252
name: TKTL2
type: Species
has only substance units: false
is: Q9H0I9
initial concentration: NaN
initial amount: NaN

metaR r1883
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaM icit c
type: Species
has only substance units: false
is: C00311
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16087
is: HMDB00193
name: Isocitrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false

metaM 4mzym int2 r
type: Species
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: SBO:0000247
is: HMDB06838
name: 4-Methylzymosterol intermediate 2
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM 13dpg c
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: CHEBI:57604
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01270
type: Species
name: 3-Phospho-D-glyceroyl phosphate
boundary condition: false
is: C00236

metaM phaccoa c
initial amount: NaN
is: CHEBI:57390
name: phenylacetyl-CoA(4-)
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB06503
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR S6TASE15ly
reversible: true
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_b99a8ecc_26a8_4c9a_b48d_a93c32b3e48d
is: E9PB82
is: SBO:0000252
is encoded by: hsa:3295
boundary condition: true
has only substance units: false
constant: false
name: HSD17B4
initial concentration: NaN
initial amount: NaN
type: Species

metaR ANTHte
is described by: ECO:0000134
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110015#
fast: false
name: Transport of anthranilate
reversible: true
reactant: MODEL1310110015#

metaM m8mpdol U r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
boundary condition: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
type: Species
has only substance units: false
is: CHEBI:59093

metaR r1487
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
reversible: true
name: EC:6.2.1.3
kinetic law: MODEL1310110015#

metaR r0780
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110015#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:

metaR CYSSNAT5tc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b19e9691_812a_453c_af8c_4f2abd6f097e
name: FLAD1
is encoded by: hsa:80308
is: SBO:0000252
is: Q8NFF5
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR RPI
name: ribose-5-phosphate isomerase
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaM acmana e
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110015#_cf116112_3872_40ac_bd79_43ecdcb260b0
is: SBO:0000252
name: TM7SF2
initial amount: NaN
is: O76062
constant: false
is encoded by: hsa:7108
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaR LEULEULAPc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR PYDXNK
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110015#
reversible: false
name: pyridoxine kinase
is: SBO:0000176
fast: false
modifier: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.35

http://identifiers.org/biomodels.db/MODEL1310110015#_b5e6278d_f5b2_45db_a844_d6a2b85b7e55
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PLCG1
is: P19174
is encoded by: hsa:5335
is: SBO:0000252
boundary condition: true

metaR FUCASE2ly
reversible: false
is: SBO:0000176
name: alpha-fucosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_76d6c361_e74c_49f9_a08e_9559fdf894fc
boundary condition: true
is encoded by: hsa:1806
name: DPYD
is: Q12882
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR GRTTx
is described by: ECO:0000134
kinetic law: MODEL1310110015#
type: Reaction
fast: false
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
name: geranyltranstransferase

metaR r2506
reactant: MODEL1310110015#
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110015#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#

metaM ksi deg7 l
is: HMDB00812
name: keratan sulfate I, degradation product 7
is: CHEBI:16953
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10

metaR DGAT
reactant: MODEL1310110015#
reversible: false
product: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.20
is: SBO:0000176
modifier: MODEL1310110015#
name: diacylglycerol acyltransferase
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_c4cae80e_f337_4c05_9c56_c22718325800
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: _AI990637_1_x
is encoded by: hsa:AI990637
type: Species
is: SBO:0000252

metaR FAS140COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110015#
name: fatty-acyl-CoA synthase (n-C14:0CoA)

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e98cdb5e_f300_466d_9754_3de093119c4b
is encoded by: hsa:64902
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: AGXT2
is: Q9BYV1
type: Species

metaM C02528 r
initial amount: NaN
is: HMDB00518
is: CHEBI:36234
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
name: chenodeoxycholate
type: Species

metaR r1886
fast: false
kinetic law: MODEL1310110015#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_12a017fe_fed9_4c05_9904_e3c72633ec37
initial amount: NaN
is encoded by: hsa:AA977580
name: _AA977580_1_c
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR SIAT9g
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.99.9

metaR UDPACGALtl
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true
fast: false
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_d7661475_7a09_4543_9757_025ee9d3cd2e
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:10861
is: Q9H2B4
boundary condition: true
name: SLC26A1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_a1eb44d0_fbf7_4965_b2ff_296bf95c1600
type: Species
has part: Q6I9V2
initial concentration: NaN
is: SBO:0000297
has only substance units: false
constant: false
has part: P25705
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:509
initial amount: NaN
boundary condition: true
is encoded by: hsa:498

metaR r0093
fast: false
type: Reaction
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
kinetic law: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_986af733_dc10_4a56_98af_386502417f54
is encoded by: hsa:80025
type: Species
is: SBO:0000252
is: Q6P1K9
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PANK2

metaM rib D c
is: CHEBI:16988
initial concentration: 1.0
is: HMDB00283
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
name: D-ribose
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3e2b1b31_4bf5_4c6c_b3b6_95930523d95c
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PIGC
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5279
is: Q92535

metaM cs a l
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:36005
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
is: HMDB02183
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain

http://identifiers.org/biomodels.db/MODEL1310110015#_6dc54260_7865_4bd0_845b_6cfd78bbf64e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10317
initial amount: NaN
name: B3GALT5
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR PROD2m
modifier: MODEL1310110015#
is described by: ECO:0000254
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
name: Proline dehydrogenase (m)
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaR CERT2rt
is: SBO:0000185
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
name: ceramide transport protein
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaR S6TASE23ly
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
product: MODEL1310110015#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM pydxn c
initial concentration: 1.0
is: CHEBI:16709
is: HMDB00239
type: Species
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: SBO:0000247
boundary condition: false
name: Pyridoxine
constant: false
initial amount: NaN
is: C00314
has only substance units: false

metaR G14T6g
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110015#
product: MODEL1310110015#

metaR DIDPtn
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
name: dIDP nuclear transport
is: SBO:0000185
type: Reaction
fast: false

metaM CE5121 m
constant: false
name: trans-3-decenoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57449

metaM cs e deg2 l
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00812
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
is: CHEBI:16953
constant: false
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110015#_655db93b_b3ac_4567_abcd_85992e59e2dc
is: P15328
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2348
is: SBO:0000252
boundary condition: true
name: FOLR1
type: Species
constant: false
initial amount: NaN

metaR HIStiDF
reversible: false
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
type: Reaction
modifier: MODEL1310110015#
is described by: ECO:0000269
name: L-histidine transport via diffusion (extracellular to cytosol)

metaM mgacpail hs r
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00220
boundary condition: false
constant: false
is: CHEBI:7896
initial concentration: 1.0
is: C00249
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_9f23918e_b225_4bb4_91a2_25459de91fd7
is: B7Z6Q4
is encoded by: hsa:3612
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: IMPA1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_c33d2406_622f_43e1_9e12_67298de299a0
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10327
name: AKR1A1
type: Species
initial amount: NaN

metaR r1994
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
type: Reaction
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110015#

metaM galgluside hs g
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
type: Species
name: galactosyl glucosyl ceramide
is: CHEBI:58223
is: HMDB00295
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00015
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3eba5149_f954_4def_977c_39d27458ed2e
type: Species
has only substance units: false
is: P05187
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:250
initial amount: NaN
constant: false
name: ALPP

metaR r0908
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110015#
is: SBO:0000185

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial concentration: 1.0
is: CHEBI:57449
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
boundary condition: false

metaR ALASm
kinetic law: MODEL1310110015#
is described by: ECO:0000254
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.37
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110015#
is: SBO:0000176
name: 5-aminolevulinate synthase

metaM dnad c
initial concentration: 1.0
is: HMDB01179
is: CHEBI:18304
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Deamino-NAD+
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false
is: C00857
type: Species

metaM sl L e
constant: false
is: CHEBI:61289
name: (S)-3-sulfonatolactate(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110015#_102cb05d_e8f2_4ef9_a36a_98ff23204bc4
initial amount: NaN
is encoded by: hsa:4124
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: MAN2A1
initial concentration: NaN
boundary condition: true
is: Q16706

http://identifiers.org/biomodels.db/MODEL1310110015#_9a101eb8_e1e2_45f3_a890_a8f25b51bba5
is: SBO:0000252
is encoded by: hsa:79611
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: ACSS3
initial amount: NaN
is: Q9H6R3

http://identifiers.org/biomodels.db/MODEL1310110015#_5fd2801f_f445_4a30_84a8_c938f04126fc
name: DPM2
is encoded by: hsa:8818
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: O94777

metaM bhb e
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
is: HMDB00011
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: SBO:0000247
constant: false

metaM fad c
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: CHEBI:16238
is: SBO:0000247
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
type: Species
initial amount: NaN
has only substance units: false
is: C00016
boundary condition: false

metaM ksi deg19 l
initial amount: NaN
constant: false
is: HMDB00812
has only substance units: false
type: Species
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
boundary condition: false
name: keratan sulfate I, degradation product 19
is: SBO:0000247
is: CHEBI:16953
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_bd5a92bf_134c_457f_be57_1165819bb82a
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8608
name: RDH16
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O75452
type: Species
constant: false

metaM ppcoa c
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
initial amount: NaN
is: CHEBI:57392
has only substance units: false
is: C00100
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB01275

metaR RE0691C
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
name: RE0691
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_b53eac41_3a4d_41c4_80ef_524f6e157b80
initial amount: NaN
type: Species
is: E7ETH5
is encoded by: hsa:9058
has only substance units: false
name: SLC13A2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR ADSK
reversible: false
product: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: adenylyl-sulfate kinase
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_14d0b4bf_80e5_486e_b9c3_2a7fabecbefb
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AA278423
initial amount: NaN
initial concentration: NaN
name: _AA278423_1_m

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR NDP8
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:

metaR r0788
product: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaM galgluside hs l
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00143
name: galactosyl glucosyl ceramide
has only substance units: false
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
type: Species

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM fad e
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:16238
is: C00016
is: SBO:0000247
has only substance units: false

metaM 3pg c
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: 3-Phospho-D-glycerate
is: SBO:0000247
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
constant: false
is: CHEBI:58272
initial concentration: 1.0
is: C00197

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c95ccca4_5652_4c65_b208_c6777a44c092
initial concentration: NaN
name: NT5C2
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: P49902
constant: false
has only substance units: false
is encoded by: hsa:22978

metaR RE3556C
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110015#
name: RE3556
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
reversible: true

metaM phytcoa x
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01359
type: Species
constant: false
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
initial concentration: 1.0
name: phytanoyl-CoA(4-)
boundary condition: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b11290ee_0ffc_4ea5_8144_f31e322769ed
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P14060
name: HSD3B1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3283

metaR IDOAASE1ly
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
name: alpha-L-iduronidase, lysosomal
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaR SUCCtp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
name: succinate transporter, peroxisome
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR GLXtp
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, peroxisomal
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR r0909
product: MODEL1310110015#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
type: Reaction
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_38cb5bc7_8c2b_44db_b4d1_c7e03109bccc
initial concentration: NaN
is: SBO:0000252
constant: false
name: PDE1A
is: Q9Y633
has only substance units: false
initial amount: NaN
is encoded by: hsa:5136
boundary condition: true
type: Species

metaR PHEACGLNt
fast: false
product: MODEL1310110015#
name: PHEACGLN extracellular transport via diffusion
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
kinetic law: MODEL1310110015#

metaR r0787
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110015#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
fast: false

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR r0892
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_fdcebe10_8871_4495_86f0_cefc03de370b
boundary condition: true
has only substance units: false
name: PDE2A
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5138
is: Q8IW54
is: SBO:0000252

metaM c226coa c
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
boundary condition: false
name: cervonyl coenzyme A
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205479
constant: false
initial concentration: 1.0
is: C16169
initial amount: NaN

metaR GARFT
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110015#
reversible: true
name: phosphoribosylglycinamide formyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
product: MODEL1310110015#

metaR UDPG4E
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: UDPglucose 4-epimerase

metaR ADMDC
is version of: http://identifiers.org/ec-code/4.1.1.50
name: adenosylmethionine decarboxylase
is described by: ECO:0000269
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_13a7c94c_c267_490f_9589_fd689f00fd78
boundary condition: true
type: Species
initial amount: NaN
name: ITPKB
is: P27987
is encoded by: hsa:3707
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_755e11cb_2c1b_49b3_8bd6_4a57fc33b4ce
type: Species
has only substance units: false
is encoded by: hsa:BE042354
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: _BE042354_1_m
initial concentration: NaN

metaM alpro m
has only substance units: false
name: S-Aminomethyldihydrolipoylprotein
constant: false
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16882

metaR BHBt
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
type: Reaction
name: (R)-3-Hydroxybutanoate transport via H+ symport
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
product: MODEL1310110015#

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR EX 3ddcrn
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM glyc3p c
is: HMDB00126
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00093
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
name: Glycerol 3-phosphate
type: Species
is: CHEBI:57597

metaR RE0583C
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
name: RE0583
is: SBO:0000176
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:

metaR r1950
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false

metaR r1771
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false

metaM fe3 e
boundary condition: false
initial concentration: 1.0
is: HMDB12943
type: Species
has only substance units: false
initial amount: NaN
name: Fe3+
constant: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: CHEBI:29034

http://identifiers.org/biomodels.db/MODEL1310110015#_2fb529ff_4ca3_4da1_8336_9da9d1a1f3cb
name: ST3GAL1
is encoded by: hsa:6482
initial amount: NaN
has only substance units: false
is: Q11201
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaM biocyt c
is: HMDB03134
boundary condition: false
is: C05552
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false

metaM dump n
name: dUMP(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
is: HMDB01409
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaR LEUKTRD4tr
name: leukotriene intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110015#_2d7632c4_e695_4d8b_a530_d094deaccca5
name: _BE966236_1_c
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:BE966236
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_0d837610_3fcc_4f19_92e6_4eaf1d1fb2dd
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:51179
name: HAO2
boundary condition: true

metaR FACOAL246 1
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_db2832d6_d20f_4276_937c_f796c4d1bdfb
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PRDX2
is encoded by: hsa:7001
is: P32119
initial amount: NaN

metaR GAL3ST11
is version of: http://identifiers.org/ec-code/2.8.2.11
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
name: Galactosylceramide sulfotransferase
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction

metaR S2TASE2ly
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110015#
reversible: false
product: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#

metaM HC01405 m
has only substance units: false
is: CHEBI:28632
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
name: (S)-Hydroxyoctanoyl-CoA
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_93a30c61_c25e_41e3_93b1_8b6fa83352c5
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2222
type: Species
name: FDFT1
has only substance units: false
initial amount: NaN
is: P37268

metaR KSII CORE2tly
reactant: MODEL1310110015#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110015#
fast: false
type: Reaction
product: MODEL1310110015#

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM lnlncg c
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
initial amount: NaN
name: gamma-linolenate
is: CHEBI:32391
initial concentration: 1.0
has only substance units: false
is: HMDB03073
is: SBO:0000247
boundary condition: false

metaM crvnc e
type: Species
constant: false
is: HMDB02183
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: cervonic acid, C22:6 n-3
is: CHEBI:36005

metaR CDIPTr
product: MODEL1310110015#
name: phosphatidylinositol synthase (Homo sapiens)
fast: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.11
reversible: true
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_9720b824_aa1e_424e_92b3_436c790461c2
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:60386
name: SLC25A19
is: Q9HC21

metaR GAL3ST12
type: Reaction
name: Galactosylceramide sulfotransferase
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.8.2.11
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_75b0bdfb_5ae2_4fe2_8814_541b7eb763f3
name: GALNT8
is: Q9NY28
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:26290
initial amount: NaN
has only substance units: false

metaR DRIBt
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: deoxyribose transport via diffusion
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction

metaM octd11ecoa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: 11-octadecenoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR FAOXC160
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
name: Beta oxidation of long chain fatty acid

metaM cdp n
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
is: HMDB01546
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58069
name: CDP(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_17d6dede_c17b_4e3c_aec1_22a184b2dc97
is: Q7Z4W1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:51181
constant: false
boundary condition: true
name: DCXR

http://identifiers.org/biomodels.db/MODEL1310110015#_35d938e3_feec_4f78_b7a0_9d9d74913399
has only substance units: false
constant: false
name: HAS2
is: Q92819
initial amount: NaN
is encoded by: hsa:3037
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR BILDGLCURt
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
product: MODEL1310110015#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
type: Reaction

metaM h2o2 x
boundary condition: false
initial concentration: 1.0
constant: false
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: SBO:0000247
name: Hydrogen peroxide
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110015#_96e88bed_681e_4eb5_b3e8_7e5a721947bf
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: _728637_1_c
initial concentration: NaN
is encoded by: hsa:728637

metaM glcur e
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
constant: false
has only substance units: false
name: D-glucuronate
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_43457b45_35f6_4f03_9d05_313986f718b5
constant: false
initial concentration: NaN
name: SULT1A1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6817
initial amount: NaN
boundary condition: true
type: Species

metaM HC02203 c
is: SBO:0000247
boundary condition: false
constant: false
name: prostaglandin-a2
initial concentration: 1.0
has only substance units: false
is: CHEBI:27820
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

http://identifiers.org/biomodels.db/MODEL1310110015#_2fe2a41b_a091_4624_b8b1_f30d4769f6da
name: ENTPD3
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:956
initial concentration: NaN
is: O75355

metaR NACHEX19ly
product: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: HMDB02183
initial concentration: 1.0
initial amount: NaN
type: Species
name: cervonic acid, C22:6 n-3
constant: false
has only substance units: false
is: CHEBI:36005

metaR S3TASE1ly
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR GAO1g
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110015#

metaR DCTPtn
is: SBO:0000185
reversible: true
type: Reaction
name: dCTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9558d2c7_d246_43c7_a461_4a5b0413b71d
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6547
boundary condition: true
is: SBO:0000252
name: SLC8A3

http://identifiers.org/biomodels.db/MODEL1310110015#_45da05e0_4f55_43cd_9ed2_45296141adb1
type: Species
boundary condition: true
is: Q9UQ53
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11282
name: MGAT4B
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_efbfaf46_3ad9_4b38_8207_523d5d2dcb37
has only substance units: false
constant: false
name: ETFB
boundary condition: true
initial concentration: NaN
is: P38117
is encoded by: hsa:2109
initial amount: NaN
type: Species
is: SBO:0000252

metaM succoa x
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
type: Species
initial amount: NaN
name: Succinyl-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM ksii core2 deg5 l
type: Species
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 5
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
is: HMDB00143
notes: FORMULA: C50H82N4O38SX CHARGE: -1

metaM trdox c
is: CHEBI:18191
is: C00343
boundary condition: false
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM CE1939 e
name: spermidine monoaldehyde 1
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:36781
is: SBO:0000247
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939

metaM 12ppd R c
initial amount: NaN
is: CHEBI:28972
constant: false
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: HMDB01881
type: Species
has only substance units: false
name: (R)-propane-1,2-diol
boundary condition: false
initial concentration: 1.0

metaR r1953
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110015#

metaM docosahexcoa m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
name: 3,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaM 3mldz c
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
constant: false
type: Species
boundary condition: false
is: HMDB04181
is: CHEBI:28104
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 1-methylimidazole-4-acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110015#_e403cd4b_7729_4c8f_9c74_0fd589d0a904
initial amount: NaN
is: SBO:0000297
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false
boundary condition: true
is encoded by: hsa:516
constant: false
initial concentration: NaN
has part: Q6FIH7

metaM dhcholestanate c
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
boundary condition: false
is: CHEBI:16577
is: HMDB00359
type: Species
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
has only substance units: false
is: SBO:0000247

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM hom L c
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: L-homoserine
is: CHEBI:15699
type: Species

metaM dhlam m
initial concentration: 1.0
type: Species
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00985
has only substance units: false

metaR NACDe
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM HC02203 e
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27820
initial amount: NaN
name: prostaglandin-a2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0

metaR r0679
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110015#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110015#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
kinetic law: MODEL1310110015#

metaR BACCLm
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
reversible: false
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000254
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_922ad62b_c8bd_4aa2_b7da_4e5f62ed6a0a
has only substance units: false
is encoded by: hsa:2678
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: GGT1

metaR FRUt4
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
name: D-fructose transport via sodium cotransport
product: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_3dee67f0_be49_4d1d_8a04_706e1924c485
is encoded by: hsa:3030
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: E9KL44
initial concentration: NaN
is: SBO:0000252
type: Species
name: HADHA

http://identifiers.org/biomodels.db/MODEL1310110015#_79c7b6ef_35b9_40a8_b438_4cbe4fc15dfd
constant: false
is encoded by: hsa:3155
name: HMGCL
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: Q6IBC0

metaM fe3 c
notes: FORMULA: Fe CHARGE: 3
type: Species
boundary condition: false
name: Fe3+
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB12943

http://identifiers.org/biomodels.db/MODEL1310110015#_2a5f1ce8_8d76_4d75_afbc_fbc809726aab
name: _R14373_1_x
constant: false
is encoded by: hsa:R14373
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR RTOTALt
name: RTOTAL transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c91aee23_29aa_41b5_a332_c03873233079
constant: false
is encoded by: hsa:9091
is: SBO:0000297
is encoded by: hsa:51227
is encoded by: hsa:5283
is encoded by: hsa:5279
has part: Q9BRB3
has part: Q14442
is encoded by: hsa:5277
initial concentration: NaN
has part: O94777
has only substance units: false
initial amount: NaN
is encoded by: hsa:8818
has part: Q92535
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: B3KUV7
boundary condition: true
type: Species

metaR ME2
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
name: malic enzyme (NADP)
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.40
is: SBO:0000176

metaM dcacoa c
initial concentration: 1.0
constant: false
is: HMDB06404
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
boundary condition: false
is: C05274
is: SBO:0000247
is: CHEBI:61430

metaR r1668
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR DUMPtn
reversible: true
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
name: dUMP nuclear transport
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_40b1457f_6214_4d0e_a431_8c59f1a1dd14
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:131669
has only substance units: false
is: Q68CJ7
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: UROC1

metaM dgsn c
type: Species
constant: false
is: SBO:0000247
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17172
boundary condition: false
is: C00330

http://identifiers.org/biomodels.db/MODEL1310110015#_d3f4e7e9_89eb_4100_ac64_acae97343394
is encoded by: hsa:PRO1933
name: _PRO1933_1_m
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_a0f2c908_c92f_44dc_a4f3_aad01db0b894
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: AMD1
is: P17707
is: SBO:0000252
is encoded by: hsa:262
boundary condition: true

metaM hom L e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
is: HMDB00719
initial amount: NaN
is: CHEBI:15699
type: Species
constant: false
has only substance units: false
name: L-homoserine

metaM dmnoncrn m
initial amount: NaN
constant: false
is: HMDB06202
name: 4,8 dimethylnonanoyl carnitine
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
type: Species
is: SBO:0000247

metaR S6TASE14ly
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110015#

metaR PPBNGS
reversible: false
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110015#
name: porphobilinogen synthase
type: Reaction
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.24
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_6e38648f_bc94_4b7f_ada4_7ca7c60c9e75
has part: P37287
is: SBO:0000297
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818
initial amount: NaN
is encoded by: hsa:5277

metaR UMPK7n
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
name: UMP kinase (dGTP),nuclear
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r1669
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_d394bbb8_9b19_4245_84c3_37b70d662208
is: B4DG68
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: NOS1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4842

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
is: C00143
initial amount: NaN
is: CHEBI:15636

http://identifiers.org/biomodels.db/MODEL1310110015#_3981f2fd_862c_47ce_910b_cb1ac6398b74
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110015#_ad427787_1b36_4827_9a7a_41dcc24c9ba7
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1606
boundary condition: true
is: P23743
is: SBO:0000252
name: DGKA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_ce5ac125_be88_4a8a_bc6c_191b92ba4f44
is encoded by: hsa:4351
has only substance units: false
name: MPI
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: P34949
is: SBO:0000252

metaR GLCt4
product: MODEL1310110015#
is described by: ECO:0000269
fast: false
name: glucose transport via sodium symport
reversible: true
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000185

metaM adn e
type: Species
boundary condition: false
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
is: C00212
initial concentration: 1.0
has only substance units: false
is: HMDB00050
is: CHEBI:16335
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_a517d6d6_da33_4194_b118_432b839ed2c2
is encoded by: hsa:1738
is: P09622
is: SBO:0000252
initial amount: NaN
name: DLD
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR ADSL2
kinetic law: MODEL1310110015#
fast: false
name: adenylosuccinate lyase
modifier: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110015#_76b4918b_00d0_4b69_9132_18c7c505afff
is encoded by: hsa:5291
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: B4DER4
is: SBO:0000252
type: Species
name: PIK3CB
has only substance units: false

metaR r1666
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true

metaR RE1254C
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
name: RE1254
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_9a04703b_2fe4_4116_b6a1_bd43079c2504
constant: false
is encoded by: hsa:55089
initial concentration: NaN
initial amount: NaN
name: SLC38A4
is: Q969I6
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1401b746_83df_4b81_b784_60076f1b778d
is encoded by: hsa:5150
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: PDE7A
initial amount: NaN

metaR r1090
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM aacoa x
constant: false
type: Species
is: HMDB01484
boundary condition: false
is: SBO:0000247
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
initial concentration: 1.0

metaR RE3628M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: RE3628
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_56490085_d5cd_4f89_846e_2bcdd8529dbf
has only substance units: false
initial amount: NaN
is encoded by: hsa:84264
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HAGHL
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_fa7eb137_4fcc_4ee3_bf6c_73b52bb669b2
type: Species
initial amount: NaN
is encoded by: hsa:9487
is: Q9Y2B2
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PIGL

http://identifiers.org/biomodels.db/MODEL1310110015#_c65691ee_b309_4128_b5de_4d259879227d
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10195
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ALG3

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: HMDB06202
is: SBO:0000247
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_2b4de48f_1a15_4b03_992d_d120e494dbec
is: SBO:0000252
initial concentration: NaN
is: P07451
type: Species
name: CA3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:761
constant: false

metaR r1667
is described by: ECO:0000000
modifier: MODEL1310110015#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_83a29fa8_cf04_47f7_b0b8_f3a0c251b2d6
name: _728226_1_e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:728226
constant: false
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_ad4b19da_9c6d_4e3b_9af6_0b7e9f14f8b9
is: Q5VSR7
is: SBO:0000252
name: PFKP
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5214
type: Species
initial concentration: NaN
has only substance units: false

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaM leuktrB4 c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
has only substance units: false
is: CHEBI:57461
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110015#_48ba2db1_025e_4273_9e03_672b284a954d
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1376
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: CPT2
is: P23786

http://identifiers.org/biomodels.db/MODEL1310110015#_b2e9bf5c_2338_45c3_b052_ed2308cb3ffd
constant: false
boundary condition: true
is encoded by: hsa:10026
is: SBO:0000252
is: Q92643
has only substance units: false
initial concentration: NaN
type: Species
name: PIGK
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_6c03a1ce_92aa_4f4d_8499_4044df0ceac8
name: NDUFS4
is encoded by: hsa:4724
constant: false
is: SBO:0000252
type: Species
is: O43181
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM adn c
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00212
is: HMDB00050
is: CHEBI:16335

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM bildglcur r
is: CHEBI:58471
is: HMDB03325
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

http://identifiers.org/biomodels.db/MODEL1310110015#_e098ba07_8c18_41f5_b757_57e3a0d5dc00
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: P16152
name: CBR1
is encoded by: hsa:873
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cb6c9872_e9a1_4446_88a8_bf7c9c5f0756
has only substance units: false
is: SBO:0000252
constant: false
name: MGAT2
is: Q10469
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4247

http://identifiers.org/biomodels.db/MODEL1310110015#_38743015_797c_432d_9d8d_eb9dd438164c
constant: false
is encoded by: hsa:1103
type: Species
is: Q6LEN6
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: CHAT

metaR r1664
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reversible: true

metaM gd3 hs g
is: CHEBI:28424
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: GD3
is: SBO:0000247
constant: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0

metaR r0672
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_cba3b0e9_04bf_418a_9d9b_c3cbd44a7826
initial concentration: NaN
is encoded by: hsa:8622
boundary condition: true
name: PDE8B
has only substance units: false
is: O95263
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR CAROtr
is described by: ECO:0000000
is: SBO:0000185
name: beta-carotene transport via diffusion
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM leuktrB4 e
has only substance units: false
is: CHEBI:57461
name: leukotriene B4(1-)
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
constant: false
initial amount: NaN

metaM bilglcur r
is: CHEBI:57767
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_834e3d9c_a9ca_4327_8081_9565992fdd70
has only substance units: false
initial amount: NaN
name: _H53099_1_m
is encoded by: hsa:H53099
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM CE4872 c
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
is: HMDB00127
is: CHEBI:15748
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0

metaM n2m2nm l
type: Species
constant: false
initial amount: NaN
name: n2m2nmasn (w/o peptide linkage)
is: SBO:0000247
is: CHEBI:30825
has only substance units: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: HMDB00573

metaM n2m2nmasn e
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
is: C04946

metaM tmndnc c
name: timnodonic acid C20:5, n-3
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: http://identifiers.org/pubchem.compound/446284
boundary condition: false
is: HMDB01999

metaR ADSL1
is version of: http://identifiers.org/ec-code/4.3.2.2
is described by: ECO:0000269
name: adenylosuccinate lyase
reversible: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176

metaR GLUPRT
fast: false
reactant: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.2.14
name: glutamine phosphoribosyldiphosphate amidotransferase
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110015#
type: Reaction

metaR AG13T2g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110015#

metaM sgalside hs g
is: CHEBI:58343
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: sulfatide galactocerebroside
is: HMDB00061
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
type: Species
has only substance units: false

metaR r1665
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110015#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaM HC02204 e
name: prostaglandin-b1
type: Species
initial concentration: 1.0
is: CHEBI:27624
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
constant: false
initial amount: NaN

metaM lnlncgcoa c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06368
is: CHEBI:57363
has only substance units: false
constant: false

metaR DOLGLCP Uter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
reversible: false
kinetic law: MODEL1310110015#

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_689664e4_2360_423f_8b1b_986232984e29
name: _AA081045_1_e
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AA081045
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR FACOAL1812
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000

metaR AACOAT
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
name: Acetoacetyl-CoA:acetate CoA-transferase
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD

metaR ACCOAgt
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
type: Reaction
name: acetyl-coa transport
reactant: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_113bf536_aa82_42c8_9a07_5a442b3d18fe
boundary condition: true
has only substance units: false
is: SBO:0000297
is encoded by: hsa:481
has part: A3KLL5
constant: false
has part: B7Z2T0
initial amount: NaN
initial concentration: NaN
name: ATP1A3:ATP1B1
is encoded by: hsa:478
type: Species

metaR S6TASE3ly
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true

metaR r2079
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110015#
type: Reaction
reversible: true
modifier: MODEL1310110015#
fast: false

metaR GBAl
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
name: Glucosylceramidase
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
kinetic law: MODEL1310110015#
reversible: false

metaM lpro m
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
name: Lipoylprotein
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15804
boundary condition: false
constant: false
type: Species

metaR r1662
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_648e9c3f_c758_48e3_87b6_afe2ccd87c45
is: Q6FGA0
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:9167
name: COX7A2L
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ae689e67_7431_4719_bc20_d9d74ae741b7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:158
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: P30566
initial concentration: NaN
name: ADSL

http://identifiers.org/biomodels.db/MODEL1310110015#_9a1669cd_ebd3_4af3_b17d_fb2912f23e3f
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:33
is: P28330
has only substance units: false
constant: false
is: SBO:0000252
name: ACADL
boundary condition: true

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM tmndnc e
has only substance units: false
is: HMDB01999
initial amount: NaN
boundary condition: false
type: Species
name: timnodonic acid C20:5, n-3
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/446284
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaR TALA
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.2.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
name: transaldolase
reversible: true

metaM gsn e
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16750
type: Species
initial concentration: 1.0
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
is: C00387
is: HMDB00133
boundary condition: false
name: Guanosine

http://identifiers.org/biomodels.db/MODEL1310110015#_1abe4cf5_ae46_4cc2_85b6_8e236c0ae97b
name: SULT1A2
has only substance units: false
is encoded by: hsa:6799
is: P50226
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaR FACOAL1813
product: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaM mlthf c
initial amount: NaN
constant: false
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: C00143

metaM nac c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Nicotinate
is: C00253
initial amount: NaN
constant: false
type: Species
is: HMDB01488
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1

metaR r0671
reversible: false
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
modifier: MODEL1310110015#
is: SBO:0000176
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
is version of: http://identifiers.org/ec-code/3.2.1.22
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
type: Reaction
is described by: ECO:0000000

metaR NACHEX8ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9623c1d4_27c4_4807_9804_1b95a611f1f4
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: Q8N695
is: SBO:0000252
type: Species
is encoded by: hsa:160728
has only substance units: false
name: SLC5A8

metaM glcur c
is: CHEBI:15748
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

metaM 2dr5p c
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: HMDB01031
type: Species
is: CHEBI:57651
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cf8a5503_8d37_4ff9_bbaf_e0b51635a17d
initial concentration: NaN
is: B3KQ63
constant: false
is encoded by: hsa:3242
has only substance units: false
name: HPD
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaR SEBACACT
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_fca96ca6_21e9_49fe_bcfb_74c209b73e64
is: A6NN98
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: MTMR2
boundary condition: true
has only substance units: false
is encoded by: hsa:8898

http://identifiers.org/biomodels.db/MODEL1310110015#_2a6fdc0b_be1c_4dd4_b34a_2ebf8f7e99b6
name: ALDH9A1
is encoded by: hsa:223
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P49189
has only substance units: false
constant: false
type: Species

metaR r1660
reversible: true
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8397b1a8_150a_4604_8a0c_ebf7e32ca9ed
is encoded by: hsa:3948
constant: false
boundary condition: true
has only substance units: false
is: P07864
is: SBO:0000252
name: LDHC
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1aa832b2_d1fa_4243_ad4f_ca68ab92dd9f
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1650
initial concentration: NaN
name: DDOST
is: P39656
boundary condition: true
is: SBO:0000252

metaR FAOXC2252053m
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f6221502_b3af_468a_941e_911b66f74983
boundary condition: true
is encoded by: hsa:2629
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: GBA
has only substance units: false
initial amount: NaN

metaM biocyt m
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
name: Biocytin
type: Species
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: HMDB03134
constant: false
initial amount: NaN
has only substance units: false

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: C01835
is: CHEBI:27931
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01262
name: maltotriose
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaM prpncoa m
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
initial concentration: 1.0
initial amount: NaN
type: Species
name: acryloyl-CoA(4-)
has only substance units: false
is: CHEBI:57367

http://identifiers.org/biomodels.db/MODEL1310110015#_6d8c1be9_82aa_4303_a634_b0bd3b3f8de7
name: DPYSL2
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1808
type: Species
is: B4DR31
has only substance units: false
boundary condition: true

metaM lald D c
name: (R)-lactaldehyde
initial concentration: 1.0
is: CHEBI:17167
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB06458
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110015#_7d745e53_94eb_4f83_a575_3e4143d8494d
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC20A2
is: B2RBR4
constant: false
boundary condition: true
type: Species
is encoded by: hsa:6575
initial concentration: NaN

metaM gsn c
is: HMDB00133
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16750
type: Species
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
name: Guanosine
is: C00387
initial amount: NaN
boundary condition: false

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
is: SBO:0000185

metaM sgalside hs c
has only substance units: false
name: sulfatide galactocerebroside
constant: false
is: HMDB03406
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16523

metaM dhcholestanate m
initial amount: NaN
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
has only substance units: false
is: HMDB00359
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM nac e
name: Nicotinate
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
type: Species
is: HMDB01488
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00253
is: CHEBI:0
boundary condition: false
has only substance units: false

metaR ALADGLYexR
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000304
reversible: true
name: D-alanine/glycine reversible exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
fast: false

metaM HC01522 c
is: SBO:0000247
constant: false
is: CHEBI:28508
initial amount: NaN
name: Gentisate aldehyde
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_971fd861_1459_443f_aa13_6725e0c723f8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: E7EPA7
constant: false
initial amount: NaN
boundary condition: true
name: TKT
is encoded by: hsa:7086
type: Species

metaM biocyt n
is: HMDB03134
type: Species
is: C05552
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
initial amount: NaN
has only substance units: false
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_4b882ed3_1c8f_4876_acb1_81775db7e6a2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:3712
name: IVD
has only substance units: false
constant: false
is: B3KVI7
initial concentration: NaN
is: SBO:0000252

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM pep m
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00263
name: Phosphoenolpyruvate
initial concentration: 1.0
is: CHEBI:18021
initial amount: NaN
is: C00074
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR r1671
name: Y+LAT2 Utilized transport
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR TETHEX3t
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_a52c3ac1_52d5_413f_9639_a07f0121ddbb
type: Species
initial amount: NaN
is encoded by: hsa:5091
has only substance units: false
initial concentration: NaN
name: PC
boundary condition: true
constant: false
is: SBO:0000252

metaM oaa c
notes: FORMULA: C4H2O5 CHARGE: -2
initial amount: NaN
is: C00036
type: Species
constant: false
boundary condition: false
is: HMDB00223
has only substance units: false
is: CHEBI:3338
name: Oxaloacetate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_1a54a80b_f8cd_4b2a_895b_4e0deaed2d16
is: SBO:0000252
is encoded by: hsa:9843
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: E9PHN8
initial concentration: NaN
name: HEPH

metaM prostgf2 e
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
is: CHEBI:57404
is: HMDB01139
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin F2alpha(1-)
has only substance units: false
type: Species

metaR P45011A1m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.15.6
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
name: Cytochrome P450 11A1, mitochondrial [Precursor]
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

metaM succoa m
is: CHEBI:57292
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
type: Species
name: Succinyl-CoA
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01022
is: SBO:0000247
constant: false

metaM n2m2nmn l
notes: FORMULA: C50H84N4O36 CHARGE: 0
constant: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
type: Species
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
is: HMDB00243
is: C00022
has only substance units: false
is: CHEBI:15361
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR B3GALT3g
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.79
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 3
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d0461e7d_9ef6_4f28_a74e_8517c2bbe900
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:160851
is: Q86XP1
boundary condition: true
name: DGKH
has only substance units: false
initial amount: NaN

metaM 2amac c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03609
boundary condition: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
initial amount: NaN
constant: false
type: Species
name: 2-aminoacrylic acid
is: CHEBI:17123

metaR r1670
reactant: MODEL1310110015#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110015#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: HMDB06537
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110015#_002ca2a4_beba_4a9e_bd61_745084140b67
constant: false
boundary condition: true
is encoded by: hsa:79646
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PANK3
type: Species
is: Q9H999
initial amount: NaN

metaR r0456
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.32

http://identifiers.org/biomodels.db/MODEL1310110015#_37645547_130c_4340_a24f_4dd866ff2f8f
is encoded by: hsa:55568
name: GALNT10
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_2910ddaa_cfbf_454e_89d8_1ed5052fb9ec
type: Species
constant: false
name: _M68895_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:M68895
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_519328b8_f114_4a96_a042_3c6c64ec7e3f
type: Species
initial concentration: NaN
is: Q02318
constant: false
name: CYP27A1
has only substance units: false
is encoded by: hsa:1593
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_71a24a2e_ce68_4cd4_8ec7_1ee648160d95
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: UEVLD
is: Q8IX04
is: SBO:0000252
is encoded by: hsa:55293
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_0631d8ab_4026_4183_86aa_3b135604980d
name: B3GNTL1
type: Species
initial concentration: NaN
is encoded by: hsa:146712
is: Q67FW5
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_b9903d48_74bb_4403_a36f_80b3d1b928e7
constant: false
initial concentration: NaN
is: P35218
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CA5A
type: Species
boundary condition: true
is encoded by: hsa:763

http://identifiers.org/biomodels.db/MODEL1310110015#_f3e7e850_17cc_43cc_851f_3077d206b53e
type: Species
is encoded by: hsa:8803
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
has part: E5KS60
is: SBO:0000297
name: SUCLG1:SUCLA2

metaM ksii core2 pre1 g
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 1

metaR DOLP Uter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
name: dolichol phosphate flippase (uterus)
fast: false
reversible: false
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b6e7d96a_b182_4c31_8fc7_4b2cb6d4fff4
has only substance units: false
is encoded by: hsa:8867
initial concentration: NaN
is: SBO:0000252
name: SYNJ1
initial amount: NaN
type: Species
constant: false
is: O43426
boundary condition: true

metaM malcoa r
initial amount: NaN
is: CHEBI:57384
is: HMDB01175
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)

metaR MI145PK
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
modifier: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.127
reversible: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269

metaR ITPtn
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: ITP nuclear transport
is described by: ECO:0000000
type: Reaction

metaM hexe3coa m
name: 3-hexenoylcoa
is: HMDB06522
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: CHEBI:57834
initial concentration: 1.0
boundary condition: false
name: Spermidine
is: C00315
initial amount: NaN
is: HMDB01257
is: SBO:0000247
constant: false
type: Species

metaR FUMAC
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110015#
type: Reaction
reversible: false
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.7.1.2
modifier: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
name: fumarylacetoacetase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_23258f06_cdc8_40b3_8102_e8af1174265c
is: Q5JT09
boundary condition: true
is encoded by: hsa:83549
constant: false
has only substance units: false
name: UCK1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_57258c52_a5b6_4e5e_a9fa_0c5c6eb32a16
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:27124
initial concentration: NaN
constant: false
name: INPP5J
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_33824602_6099_4120_a1b5_d0aee75b44d6
is: Q96M32
initial concentration: NaN
boundary condition: true
is encoded by: hsa:122481
constant: false
initial amount: NaN
has only substance units: false
name: AK7
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_e2122a37_def1_4f25_ac21_b228ee8c5386
is encoded by: hsa:6391
type: Species
has part: O14521
has only substance units: false
has part: Q99643
has part: P21912
constant: false
is encoded by: hsa:6390
is: SBO:0000297
initial amount: NaN
has part: P31040
is encoded by: hsa:6389
boundary condition: true
is encoded by: hsa:6392
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD

metaR GPAM hs
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.15
reversible: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
name: glycerol-3-phosphate acyltransferase
fast: false
modifier: MODEL1310110015#

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_8830e34a_46e3_4ad3_814d_8567bcc59013
initial amount: NaN
constant: false
is: B4DYG5
name: PI4KA
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5297
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_654c0cba_9788_455e_97ae_0fd59606c753
name: FOLR1
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110015#_5cc7c26f_411d_47e9_bb56_e24841408604
has only substance units: false
is encoded by: hsa:1718
name: DHCR24
initial concentration: NaN
initial amount: NaN
is: Q15392
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM pail5p hs n
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
type: Species
is: CHEBI:57795
boundary condition: false

metaM oh1 c
initial amount: NaN
name: hydroxide ion
constant: false
type: Species
notes: FORMULA: HO CHARGE: -1
boundary condition: false
is: HMDB01039
is: C01328
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_920fabe2_18a6_407e_9471_bcbeb31e2437
name: PLCB1
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:23236
initial amount: NaN
initial concentration: NaN

metaR 7DHCHSTEROLtr
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
name: cholesterol precursor intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110015#_a4726ae1_7de0_4888_b352_38719189e3cf
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5092
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P61457
name: PCBD1
initial amount: NaN

metaM ksi deg40 l
name: keratan sulfate I, degradation product 40
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C40H68N2O31 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110015#_046ff967_724e_4369_afdc_772dcc1e7484
name: PNPO
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NVS9
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:55163

metaR biomass reaction
is described by: ECO:0000134
product: MODEL1310110015#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110015#
name: biomass_reaction
fast: false
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaR RE1807M
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
is: SBO:0000176
name: RE1807
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR GLCter
fast: false
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
type: Reaction

metaM C02528 e
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
is: HMDB00518
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36234

metaR G14T15g
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM sphings c
type: Species
boundary condition: false
constant: false
is: CHEBI:57756
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
is: SBO:0000247
name: sphingosine(1+)
is: HMDB00252

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaM acrn m
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: O-acetylcarnitine
is: HMDB00201

http://identifiers.org/biomodels.db/MODEL1310110015#_3bb137da_b2a5_4830_b9bf_e6b8022e0a72
name: PIK3R3
is: Q92569
is encoded by: hsa:8503
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_d65b965d_846d_42b2_bf20_b9a5e67252a0
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q16842
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6483
constant: false
name: ST3GAL2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_37634489_eed5_4fc7_a25e_4b833c793838
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: FOLR1
is encoded by: hsa:2348
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_2eb34a96_1e07_40cd_87b0_9db1e7c471f8
type: Species
is: Q53TV9
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: RPE
has only substance units: false
is encoded by: hsa:6120
is: SBO:0000252

metaR G14T2g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_5337fa6e_910c_4f3e_a28d_64ef8ff583ee
initial concentration: NaN
is encoded by: hsa:AA664770
has only substance units: false
type: Species
name: _AA664770_1_m
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaM aacoa c
is: HMDB01484
type: Species
constant: false
boundary condition: false
is: C00332
initial concentration: 1.0
initial amount: NaN
name: Acetoacetyl-CoA
is: CHEBI:57286
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247

metaM acrn r
initial concentration: 1.0
name: O-acetylcarnitine
is: HMDB00201
is: CHEBI:57589
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
constant: false

metaM HC10852 r
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
has only substance units: false
initial amount: NaN
type: Species
name: palmitoleyl-CoA(4-)
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:61540

metaM CE4872 m
is: SBO:0000247
type: Species
is: HMDB00127
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: CHEBI:15748
initial concentration: 1.0

metaM spmd c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
boundary condition: false
name: Spermidine
type: Species
is: CHEBI:57834
is: C00315
is: SBO:0000247
initial amount: NaN
is: HMDB01257
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_fcea6c73_1b91_42d8_a974_7564027328ba
is encoded by: hsa:5320
name: PLA2G2A
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: P14555
is: SBO:0000252
constant: false

metaR FACOAL180i
is: SBO:0000176
reversible: false
product: MODEL1310110015#
name: C180 fatty acid activation
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_c2ab97b7_4d97_4418_85b3_221fdfbbe470
name: PIGF
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5281
is: SBO:0000252
is: Q07326
initial concentration: NaN

metaR SUCOASm
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0330157d_a8c5_4e45_b64c_49f010391f36
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI024818
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: _AI024818_1_c

metaR RE1531M
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110015#
name: RE1531
type: Reaction
product: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110015#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_2b5b6b6b_dd68_47e0_b432_09c68feb20a3
name: SLC29A2
constant: false
has only substance units: false
is: Q14542
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3177

metaR ECOAH9m
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
product: MODEL1310110015#
fast: false
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

metaR NADtx
reversible: true
name: transport of NAD into peroxisome
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM C02528 c
is: CHEBI:36234
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00518
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate

metaM ptth m
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
is: CHEBI:16753
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: pantetheine
is: HMDB03426
has only substance units: false

metaM sgalside hs l
is: HMDB00904
type: Species
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
constant: false
is: CHEBI:16349
is: SBO:0000247
has only substance units: false
boundary condition: false
name: sulfatide galactocerebroside

metaR DNDPt33m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
name: dGDP transport via dUDP antiport
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#

metaM dcyt c
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
name: Deoxycytidine
has only substance units: false
is: CHEBI:15698
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00014
is: C00881
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_06085264_836f_46d4_8bb4_8f8a783ffa18
is encoded by: hsa:6487
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ST3GAL3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_250d64ab_bb54_4411_90f8_f3a1f85cee8d
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC13A4
is encoded by: hsa:26266
is: Q9UKG4

metaM orot5p c
is: HMDB00218
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
constant: false
is: C01103
initial amount: NaN
name: Orotidine 5'-phosphate
boundary condition: false
is: CHEBI:57538
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_a6baf67e_415b_4d3e_baa3_e62b2dc4f85c
boundary condition: true
is encoded by: hsa:200010
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC5A9
is: SBO:0000252
constant: false
type: Species
is: E9PAK4

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57795
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: SBO:0000247

metaR CORE2GTg
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: false

metaM prostgf2 c
initial amount: NaN
type: Species
is: CHEBI:57404
is: HMDB01139
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin F2alpha(1-)
has only substance units: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false

metaR MI145PP
kinetic law: MODEL1310110015#
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110015#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaR r0450
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is: SBO:0000176
reversible: true
modifier: MODEL1310110015#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_311453fe_2219_4d41_9d00_faf2895d25b8
has only substance units: false
type: Species
initial concentration: NaN
name: TPH2
is: Q8IWU9
is encoded by: hsa:121278
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR ORNt4m
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
type: Reaction
modifier: MODEL1310110015#
is described by: ECO:0000269
name: ornithine mitochondrial transport exchange with citruline
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110015#

metaR DNDPt22m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
name: dTDP transport via dUDP antiport
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
reversible: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM dhcholestanate x
boundary condition: false
type: Species
is: HMDB00359
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
is: CHEBI:16577

metaR BILIRUBtr
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
reversible: true
reactant: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_d665a9c7_4cac_4019_9afc_5b0086093d9c
initial amount: NaN
name: GALNT9
is: SBO:0000252
boundary condition: true
type: Species
is: Q9HCQ5
is encoded by: hsa:50614
constant: false
has only substance units: false
initial concentration: NaN

metaR IDOAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110015#
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_8f73d44d_b26e_498e_9360_617117d10dc1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: ALDH3B1
is: P43353
is encoded by: hsa:221
initial amount: NaN
boundary condition: true

metaM dcacoa m
is: C05274
constant: false
type: Species
is: HMDB06404
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
has only substance units: false
is: CHEBI:61430
initial amount: NaN
initial concentration: 1.0

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_ea6ec6ba_2937_4682_89b4_e054c9c01602
initial concentration: NaN
type: Species
name: B3GALT5
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10317
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_1a5e8d75_04d2_4979_afe8_9dcc5bf06e2b
constant: false
is encoded by: hsa:64834
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q9BW60
initial concentration: NaN
is: SBO:0000252
name: ELOVL1

metaR OLEICFATPtc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM nmn c
has only substance units: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455
is: HMDB00229
initial concentration: 1.0
is: CHEBI:14649
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: NMN

http://identifiers.org/biomodels.db/MODEL1310110015#_987ae122_a022_4e1a_8033_453fb9df99af
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:7166
is: P17752
name: TPH1
constant: false
type: Species
is: SBO:0000252

metaM acrn x
is: CHEBI:57589
initial concentration: 1.0
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial amount: NaN
constant: false
name: O-acetylcarnitine
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM 5mthf c
constant: false
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
is: HMDB01396
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00440
name: 5-Methyltetrahydrofolate
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110015#_041ee272_e98d_4ef8_a6ee_e8abe732e3c2
constant: false
is: SBO:0000252
name: CHST6
is: Q9GZX3
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4166
initial concentration: NaN

metaR TYRTA
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110015#
fast: false
name: tyrosine transaminase
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR ALADGLNexR
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
product: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_f1fd15fc_4071_4211_8bb4_e42d6a35335a
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: COX7C
is: P15954
is encoded by: hsa:1350
constant: false
type: Species

metaM sphings l
is: HMDB00252
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
boundary condition: false
initial amount: NaN
name: sphingosine(1+)
constant: false
is: CHEBI:57756
has only substance units: false

metaM acac e
name: acetoacetate
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00060
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
is: CHEBI:13705
constant: false
type: Species

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR RE1807C
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
name: RE1807
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false

metaM oaa m
constant: false
is: CHEBI:16452
has only substance units: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial concentration: 1.0
name: Oxaloacetate
is: HMDB00223
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00036
type: Species

metaR FACOAL184
is: SBO:0000176
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110015#
fast: false
name: fatty-acid--CoA ligase
type: Reaction

metaM pheacgln e
is: HMDB06344
initial amount: NaN
constant: false
boundary condition: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
type: Species
is: SBO:0000247

metaM pi x
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:43474
initial amount: NaN
name: hydrogenphosphate
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110015#_d63760e7_a7e3_4b9b_b547_905e96a74dcc
name: ADSSL1
is: SBO:0000252
constant: false
is encoded by: hsa:122622
boundary condition: true
has only substance units: false
is: Q8N142
initial amount: NaN
type: Species
initial concentration: NaN

metaR DPCOAPPe
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
type: Reaction
name: Pyrophasphatase (dephospho-CoA, extracellular)
reactant: MODEL1310110015#
is described by: ECO:0000134

metaM pristcoa x
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: pristanoyl coa
is: CHEBI:51341
has only substance units: false
initial concentration: 1.0

metaM lnlncgcoa m
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
constant: false
initial concentration: 1.0
type: Species
name: gamma-linolenoyl-CoA(4-)

metaR TRPHYDRO2
type: Reaction
fast: false
reversible: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.14.16.4
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1

http://identifiers.org/biomodels.db/MODEL1310110015#_8f2532cf_e17f_4d6a_bca2_e034409423a0
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:1635
is: SBO:0000252
is: P32321
type: Species
name: DCTD

metaM 5mthf e
constant: false
name: 5-Methyltetrahydrofolate
type: Species
is: SBO:0000247
is: HMDB01396
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: CHEBI:3729
boundary condition: false
is: C00440

metaR ATP1ter
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110015#
fast: false
reversible: true
product: MODEL1310110015#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: ADP/ATP transporter, endoplasmic reticulum

metaM fadh2 c
is: SBO:0000247
name: FADH2(2-)
initial amount: NaN
has only substance units: false
is: HMDB01197
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_bf73f699_2a8a_43ab_8941_0b054d75081d
initial amount: NaN
is: SBO:0000252
constant: false
is: P36021
initial concentration: NaN
type: Species
name: SLC16A2
has only substance units: false
boundary condition: true
is encoded by: hsa:6567

http://identifiers.org/biomodels.db/MODEL1310110015#_48eba96b_36bd_4c0b_98ba_db2bfb16d241
is: P08397
has only substance units: false
boundary condition: true
type: Species
name: HMBS
constant: false
initial amount: NaN
is encoded by: hsa:3145
is: SBO:0000252
initial concentration: NaN

metaR TCHOLAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
name: bile acid intracellular transport
kinetic law: MODEL1310110015#
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185

metaM glcur l
type: Species
has only substance units: false
name: D-glucuronate
is: CHEBI:15748
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247

metaM pcrn c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738
constant: false
has only substance units: false
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
is: HMDB00824

metaR FAOXC18280m
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110015#
name: Beta oxidation of fatty acid
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false

metaR MG3er
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_02f52c82_43bf_46e9_9f21_9bc3e833e74f
constant: false
is: SBO:0000252
has only substance units: false
is: O94788
initial concentration: NaN
name: ALDH1A2
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:8854

metaM hexccoa x
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06459

metaM ksii core4 deg1 l
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: CHEBI:57737
has only substance units: false
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 1
is: HMDB00868

metaM CE2705 n
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02281
type: Species
is: CHEBI:15374
initial concentration: 1.0

metaM acac c
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
boundary condition: false
is: HMDB00060
is: CHEBI:13705
name: acetoacetate

metaM anth c
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567
is: HMDB01123
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: anthranilate
has only substance units: false

metaM dmnoncrn x
is: SBO:0000247
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB06202
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110015#_7a8594aa_217c_46e3_8a1e_8d2c05ef8453
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1603
is: SBO:0000252
is: Q53G02
type: Species
name: DAD1
has only substance units: false

metaM pheacgln c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:58310
is: HMDB06344
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110015#_f55e5469_62aa_4845_ae2b_0052e1ea07b1
boundary condition: true
is encoded by: hsa:2593
initial concentration: NaN
name: GAMT
initial amount: NaN
is: SBO:0000252
type: Species
is: Q14353
has only substance units: false
constant: false

metaR UPPN
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110015#
name: b-ureidopropionase

http://identifiers.org/biomodels.db/MODEL1310110015#_01210a17_fc58_4db5_b684_c25cd7a52f63
is: P23378
is encoded by: hsa:2731
has only substance units: false
boundary condition: true
name: GLDC
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_e307bd5c_0613_4f92_a2c2_a064a0b307be
name: MGST3
boundary condition: true
type: Species
is: O14880
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4259

metaM nrpphr e
type: Species
initial amount: NaN
is: SBO:0000247
name: Norepinephrine
is: CHEBI:33569
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_c8c8a1c8_ebfc_4f4e_8c38_036358871543
is: P50224
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6818
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SULT1A3

metaR M1316Mg
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.114
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

metaM leuktrA4 r
is: SBO:0000247
is: CHEBI:57463
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01337

metaM nrpphr c
initial concentration: 1.0
constant: false
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:33569
has only substance units: false

metaM oh1 e
type: Species
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
is: HMDB01039
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C01328
boundary condition: false
constant: false
is: SBO:0000247

metaR RE1573M
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110015#
name: RE1573
fast: false
modifier: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_a9e8ffc2_b43f_4f09_8c4e_0f087dc590df
initial amount: NaN
is encoded by: hsa:224
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: ALDH3A2
is: SBO:0000252
has only substance units: false
is: P51648

metaR BTNPL
reactant: MODEL1310110015#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: holocarboxylase synthestase (biotin protein ligase)
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_1feeaf23_b88b_4f4d_b2c0_692688f432a3
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:56894
boundary condition: true
initial concentration: NaN
type: Species
name: AGPAT3
is: Q9NRZ7
has only substance units: false

metaR RE1447M
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110015#
name: RE1447
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR FAOXC163GC142m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM octd11ecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB02288
type: Species
constant: false
name: 11-octadecenoylcoa
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR TMDS
name: thymidylate synthase
type: Reaction
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
reversible: false
product: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.1.45

metaR LCADi
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110015#
is described by: ECO:0000304
type: Reaction
reversible: false
kinetic law: MODEL1310110015#
name: lactaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is: SBO:0000176

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00929
has only substance units: false
type: Species
is: CHEBI:16828
initial concentration: 1.0
name: L-tryptophan
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_66d9ae23_f0e6_4ac0_bde7_42cf7d6ac82c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AL048840
is: SBO:0000252
name: _AL048840_1_c
constant: false
boundary condition: true

metaM anth e
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: HMDB01123
is: SBO:0000247
is: CHEBI:16567
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: anthranilate

http://identifiers.org/biomodels.db/MODEL1310110015#_554ad277_adfd_4225_b1b1_f6de71abf60d
boundary condition: true
name: ECI2
is: SBO:0000252
constant: false
is encoded by: hsa:10455
type: Species
has only substance units: false
initial concentration: NaN
is: O75521
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_4cac920b_6580_4d60_8326_75adee45ac05
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:123041
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: SLC24A4

metaM lnlncg e
is: CHEBI:32391
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
name: gamma-linolenate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_f57668e4_4c22_4dea_a9c0_97b1d3f628ea
name: ADH1B
initial amount: NaN
constant: false
is encoded by: hsa:125
is: SBO:0000252
is: P00325
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
is: SBO:0000176

metaM glcur r
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
initial concentration: 1.0
is: CHEBI:15748

metaR RE1522M
is: SBO:0000176
name: RE1522
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_e1d25295_b84e_4db9_80c3_417f4c890c39
initial amount: NaN
is encoded by: hsa:7378
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: UPP1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_1d044a5d_7dee_4bc4_8495_d3700be7c2ac
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: A0S0A7
constant: false
has only substance units: false
is encoded by: hsa:4846
name: NOS3

metaM lnlncgcoa r
type: Species
is: CHEBI:57363
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR GALASE20ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110015#
name: beta-galactosidase, lysosomal

metaR RE1447N
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: RE1447
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: true
fast: false

metaR MALSO3tm
reversible: true
reactant: MODEL1310110015#
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR 3AIBtm
reversible: false
fast: false
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
name: 3-amino-isobutyrate transport, mitochondrial
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110015#

metaM ksi pre9 g
is: C00130
type: Species
is: HMDB00175
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
constant: false
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM aacoa m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57286
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
name: acetoacetyl-CoA(4-)
boundary condition: false
constant: false

metaR SERPT
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.50
name: serine C-palmitoyltransferase
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110015#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_2e9b95d4_4157_4270_b11c_326202a3a2a8
name: HMGCR
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P04035
is encoded by: hsa:3156
has only substance units: false
boundary condition: true

metaM pep c
constant: false
is: SBO:0000247
is: CHEBI:18021
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial amount: NaN
is: HMDB00263
boundary condition: false
has only substance units: false
name: Phosphoenolpyruvate
initial concentration: 1.0
type: Species
is: C00074

metaM 4ppan c
initial amount: NaN
is: SBO:0000247
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
is: C03492
is: CHEBI:10986
constant: false
boundary condition: false
type: Species
has only substance units: false
name: D-4'-Phosphopantothenate

metaR LNLNCAt
product: MODEL1310110015#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110015#
reversible: true
type: Reaction

metaR H2CO3D
modifier: MODEL1310110015#
type: Reaction
name: carboxylic acid dissociation
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
fast: false

metaM trdox m
is: CHEBI:18191
constant: false
boundary condition: false
name: Oxidized thioredoxin
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_83892a7d_d45f_4f06_9b2b_c1219aed15a0
name: ALG8
initial amount: NaN
boundary condition: true
is encoded by: hsa:79053
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaM ksi deg26 l
has only substance units: false
initial amount: NaN
is: CHEBI:58343
constant: false
type: Species
name: keratan sulfate I, degradation product 26
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061
initial concentration: 1.0
is: SBO:0000247

metaM trp L c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00929
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
is: CHEBI:16828
boundary condition: false

metaR PI45P5P
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_59e7b8b0_8afc_44e8_a2b6_dcd44c641ae4
is: P07205
is encoded by: hsa:5232
type: Species
boundary condition: true
name: PGK2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e8b99789_e755_4dbb_b992_2b56eb73fe06
is encoded by: hsa:2879
is: P36969
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: GPX4
boundary condition: true
is: SBO:0000252

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_456a8ea2_ba36_4903_ae04_30ace42b80c3
initial amount: NaN
has only substance units: false
is: O75610
name: LEFTY1
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:10637

http://identifiers.org/biomodels.db/MODEL1310110015#_c9b7a3ca_f63a_4c5c_afe7_9cf27b711661
has only substance units: false
is: A0S0A7
initial concentration: NaN
initial amount: NaN
name: NOS3
is: SBO:0000252
is encoded by: hsa:4846
type: Species
boundary condition: true
constant: false

metaR PROSTGE2t
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110015#
type: Reaction

metaR LSTO1r
kinetic law: MODEL1310110015#
name: Lathosterol oxidase
fast: false
reversible: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
is: SBO:0000176

metaR DHFtm
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
name: dihydrofolate reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
reactant: MODEL1310110015#
reversible: true
type: Reaction

metaR NCNt
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: true
name: Na+/Ca2+-NH4+ exchange
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false

metaM HC02175 e
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27689
initial concentration: 1.0
name: caprate
type: Species
boundary condition: false
constant: false

metaR r0668
is: SBO:0000176
kinetic law: MODEL1310110015#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
type: Reaction
reversible: true
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_e83fd2f5_f9f7_4e3d_90d5_916d48c465e5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q14749
is encoded by: hsa:27232
name: GNMT

http://identifiers.org/biomodels.db/MODEL1310110015#_a311fd17_d825_4e25_bf28_aeeb2eb18372
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9H6Y6
name: MYO5B
boundary condition: true
is encoded by: hsa:4645
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_6d60c6f9_3a1d_441a_a525_61dfd0812cc4
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI620219
constant: false
name: _AI620219_1_c
has only substance units: false
is: SBO:0000252
type: Species

metaR NACASPAH
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.15
name: N-Acetyl-L-aspartate amidohydrolase
is: SBO:0000176
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_fe0d74e1_6702_424d_a072_13c48ab94e75
type: Species
is encoded by: hsa:3945
has only substance units: false
initial concentration: NaN
is: P07195
boundary condition: true
is: SBO:0000252
name: LDHB
initial amount: NaN
constant: false

metaM pcrn m
initial amount: NaN
constant: false
is: HMDB00824
boundary condition: false
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial concentration: 1.0
name: propionyl-carnitine
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247

metaM pentcoa m
initial amount: NaN
name: pentanoylcoa
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB13037
is: C00888
has only substance units: false
is: SBO:0000247

metaM HC02205 e
is: CHEBI:28099
has only substance units: false
name: prostaglandin-b2
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaM ksii core2 pre10 g
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_488af9b4_485c_4a42_8f07_48ee9b54b910
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9435
name: CHST2
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q9Y4C5

http://identifiers.org/biomodels.db/MODEL1310110015#_a3afd0c1_5fe6_45f7_95eb_16862fba3ab8
has part: Q8WYR1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23533
is: SBO:0000297
constant: false
boundary condition: true
name: PIK3R5:PIK3CG

metaR CAt7r
fast: false
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000269
name: calcium / sodium antiporter (1:3), reversible
reversible: true
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_f8c108e6_c0ae_401d_93fd_b0e0d44e06dd
has only substance units: false
boundary condition: true
is: O15427
name: SLC16A3
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9123
is: SBO:0000252
initial concentration: NaN

metaM acac m
boundary condition: false
name: acetoacetate
is: CHEBI:13705
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
has only substance units: false
initial amount: NaN

metaR r0669
reactant: MODEL1310110015#
is: SBO:0000176
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

metaR RE3244R
is described by: ECO:0000000
is: SBO:0000176
name: RE3244
type: Reaction
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaR r1783
reactant: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi l
constant: false
name: keratan sulfate I
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455
is: C00445
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: HMDB01354

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM ddsmsterol r
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
name: 7-dehydrodesmosterol
is: CHEBI:27910
is: SBO:0000247
is: HMDB03896
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373

http://identifiers.org/biomodels.db/MODEL1310110015#_267f5276_427e_494b_8a52_30d787c53efe
is encoded by: hsa:5634
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: PRPS2
type: Species
is: P11908
initial amount: NaN

metaR SPC HSt
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
name: sphingosylphosphorylcholine transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
reversible: true
type: Reaction
reactant: MODEL1310110015#

metaM HC02175 c
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: caprate
initial amount: NaN
is: CHEBI:27689
type: Species
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1

metaM didp c
is: SBO:0000247
name: dIDP
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28823
is: HMDB03536
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaR ILETAm
is: SBO:0000176
type: Reaction
name: isoleucine transaminase, mitochondrial
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r2199
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
fast: false
reversible: true
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_1e28babe_fb72_4cf4_bcff_92394440f8d4
type: Species
is: P78381
initial concentration: NaN
name: SLC35A2
has only substance units: false
is encoded by: hsa:7355
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_21d3133f_610d_4357_8e34_d000e4651a7c
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: BCKDHB
is: P21953
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:594

http://identifiers.org/biomodels.db/MODEL1310110015#_0eb29981_733c_43c4_b814_255b8f6f9b9a
name: NT5C1B
is encoded by: hsa:93034
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: B3KUK6
has only substance units: false
type: Species
initial amount: NaN

metaM HC02205 c
type: Species
initial amount: NaN
name: prostaglandin-b2
is: CHEBI:28099
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR FAOXC185m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_8f10d5f9_b4fc_4c2c_b1b2_8820c8fc228c
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:51227
constant: false
boundary condition: true
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR TYRCBOX
kinetic law: MODEL1310110015#
name: L-Tyrosine carboxy-lyase
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000134
reversible: false
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#

metaR It
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
name: Iodide uniport
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
modifier: MODEL1310110015#

metaR UMPK6n
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
fast: false
name: UMP kinase (dCTP),nuclear
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110015#
reversible: true

metaM 2mop m
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
type: Species
is: HMDB01172
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_b20e89e0_36b6_44ad_a0a5_6557a493c5b0
boundary condition: true
has only substance units: false
constant: false
name: PIK3C2B
type: Species
initial amount: NaN
is encoded by: hsa:5287
initial concentration: NaN
is: SBO:0000252
is: O00750

metaM ksi pre16 g
has only substance units: false
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 16
initial amount: NaN
type: Species
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: SBO:0000247
boundary condition: false
constant: false
is: C00130
initial concentration: 1.0

metaR FAOXC163C164Gm
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM lneldc c
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06270
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
boundary condition: false
name: linoelaidic acid (all trans C18:2)

http://identifiers.org/biomodels.db/MODEL1310110015#_b0d666e7_ccd3_4aa0_a89a_80db237bf789
initial concentration: NaN
type: Species
has only substance units: false
name: ENTPD8
is: Q5MY95
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:377841

metaM cit e
is: HMDB00094
is: CHEBI:16947
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
name: citrate(3-)
type: Species

metaM HC02179 c
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: 20-hydroxy-arachidonate
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
is: CHEBI:34306

http://identifiers.org/biomodels.db/MODEL1310110015#_64e51129_1ad2_40b5_8fcc_9c3b30ea8f2d
type: Species
boundary condition: true
is encoded by: hsa:28976
name: ACAD9
initial concentration: NaN
initial amount: NaN
is: Q9H845
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_69e8b66f_493c_41d1_acc5_1cbb1198a294
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6391
name: SDHC
is: Q99643

metaM Lcystin c
name: L-cystine
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
boundary condition: false
is: HMDB00192
is: CHEBI:16283
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_770be56c_6153_40b8_96d3_a1f733cbab88
is: SBO:0000252
name: CYP4F2
boundary condition: true
is: P78329
is encoded by: hsa:8529
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR GHMT2rm
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.1.2.1
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reversible: true
kinetic law: MODEL1310110015#
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
type: Reaction

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM fdp c
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: C00354
name: D-Fructose 1,6-bisphosphate
constant: false
is: CHEBI:16905
initial amount: NaN
is: SBO:0000247
is: HMDB01058
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3647

metaM lgnc e
type: Species
name: lignocerate
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:31014
is: HMDB02003
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_8788ed20_41ca_4026_9613_b48b37f45fec
is encoded by: hsa:2645
is: Q53Y25
constant: false
is: SBO:0000252
type: Species
name: GCK
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM pect e
type: Species
notes: FORMULA: C2535H3509O2535 CHARGE: -1
has only substance units: false
name: pectins
is: SBO:0000247
is: HMDB03402
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_71aa682e_5100_4f75_a068_9cfb7a3295db
initial amount: NaN
is encoded by: hsa:2629
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: GBA
initial concentration: NaN
is: B7Z6S9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_640f2600_036a_44ba_95a3_4fc9c1f7eacb
type: Species
name: ACOT1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:641371
boundary condition: true
initial amount: NaN
constant: false
is: E9KL42

metaR 5HLTDL
modifier: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_f64e910c_23b4_4e5e_b79a_c0151daf1d6e
type: Species
has part: B7Z3U6
is encoded by: hsa:483
initial concentration: NaN
initial amount: NaN
name: ATP1A1:ATP1B3
constant: false
has part: P54709
has only substance units: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:476

http://identifiers.org/biomodels.db/MODEL1310110015#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM e4p c
type: Species
is: CHEBI:16897
boundary condition: false
is: C00279
name: D-Erythrose 4-phosphate
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: SBO:0000247
is: HMDB01321
initial concentration: 1.0

metaM acrn c
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
has only substance units: false
is: HMDB00201
constant: false
is: CHEBI:57589
type: Species
name: O-acetylcarnitine
boundary condition: false
initial amount: NaN

metaR r0666
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_fbdf2de4_7ae1_4e43_a1f8_06b20f67c996
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P19440
is encoded by: hsa:2678
type: Species
initial amount: NaN
name: GGT1
initial concentration: NaN
constant: false

metaM cit c
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
is: CHEBI:16947
has only substance units: false
is: SBO:0000247
is: C00158
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM HC02179 e
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: 20-hydroxy-arachidonate
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false

metaR r1966
is: SBO:0000185
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110015#
name: Y+LAT2 Utilized transport

metaM ksi g
has only substance units: false
name: keratan sulfate I
initial amount: NaN
is: CHEBI:17140
boundary condition: false
initial concentration: 1.0
is: HMDB01644
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_bc2dcda2_882b_4556_bb32_81dca415d699
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4830
type: Species
name: NME1
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM malcoa c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: C00083
initial concentration: 1.0
boundary condition: false
is: HMDB01175
name: Malonyl-CoA
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_4ee2d922_f7da_4206_b7a1_148f24c9c918
is: SBO:0000252
name: SLC6A9
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6536
is: P48067
constant: false

metaR PHCHGSm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_e611ad87_7d47_4b4e_b668_3a8ced981c4b
name: _R51273_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:R51273
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR RE0915E
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
type: Reaction
name: RE0915

metaR FAOXC9C7m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: C00130
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:58053
boundary condition: false
has only substance units: false
is: HMDB00175

metaR DALAt2r
is: SBO:0000185
name: D-alanine transport via proton symport
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_24551373_5a65_45cf_9b21_91dbf3e6863b
boundary condition: true
name: DPAGT1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1798

metaR RE1898C
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1898
is described by: ECO:0000000
reactant: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
type: Reaction
reversible: true

metaR AG13T3g
product: MODEL1310110015#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction

metaR GALK
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.6
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.157
fast: false
name: galactokinase
modifier: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
type: Reaction

metaM lgnc c
type: Species
is: HMDB02003
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:31014
name: lignocerate
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
has only substance units: false

metaM dcyt n
name: 2'-deoxycytidine
is: HMDB00014
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:15698
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
boundary condition: false

metaM naglc2p U c
initial concentration: 1.0
has only substance units: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
boundary condition: false
initial amount: NaN
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
constant: false
is: SBO:0000247
is: CHEBI:18278
type: Species

metaM cholcoaone x
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB06891
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467

metaR r0660
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.5.1.2
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110015#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaR SEBACIDTD
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM didp n
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03536
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
constant: false

metaM lneldccrn m
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
has only substance units: false
is: HMDB06461
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Linoelaidyl carnitine
initial amount: NaN
boundary condition: false

metaM iodine c
is: CHEBI:24859
notes: FORMULA: I2 CHARGE: 0 INCHI: InChI=1S/I EHMN_ABBREVIATION: C01382
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00675
initial amount: NaN
name: Iodine

http://identifiers.org/biomodels.db/MODEL1310110015#_b7276c79_ee36_4f6d_9063_d97bde7b5d79
is encoded by: hsa:80150
initial amount: NaN
has only substance units: false
is: Q7L266
type: Species
is: SBO:0000252
name: ASRGL1
initial concentration: NaN
constant: false
boundary condition: true

metaR C204CPT2
kinetic law: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
fast: false
type: Reaction
name: arachidonic acid transport into the mitochondria
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_6768ce82_7391_4658_927d_a35c36f36708
has only substance units: false
has part: P18859
is encoded by: hsa:518
has part: P24539
is encoded by: hsa:515
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: O75947
constant: false
type: Species
is encoded by: hsa:10476
is encoded by: hsa:522
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_c9e30ecf_1527_4c3c_ae35_7833f0d9efeb
is: SBO:0000252
type: Species
is encoded by: hsa:4860
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P00491
name: PNP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1d272853_0497_4852_83b5_8c9c6dde5d92
initial concentration: NaN
type: Species
is: SBO:0000252
is: P80404
constant: false
name: ABAT
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:18

metaR FAOXC141C121m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_e239f624_7280_45fe_b1e0_94bf67c3f948
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2109
name: ETFA:ETFB
is: SBO:0000297
initial concentration: NaN
has part: P38117
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_2ecd1e18_7611_448d_8c66_b9d23324d171
boundary condition: true
type: Species
name: CROT
is encoded by: hsa:54677
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: E7EQF2
is: SBO:0000252

metaR SUCRe
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
name: sucrose hydrolyzing enxyme, extracellular
modifier: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.10
fast: false
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20

http://identifiers.org/biomodels.db/MODEL1310110015#_4dcf75f8_73ad_4ab3_b71e_a064b0d0de80
is encoded by: hsa:2235
name: FECH
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q7KZA3
initial amount: NaN
has only substance units: false

metaR r0661
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110015#
fast: false
type: Reaction
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_d825e766_1c66_4660_b247_c8460b9f1c75
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: O60476
is: SBO:0000252
name: MAN1A2
constant: false
boundary condition: true
is encoded by: hsa:10905

metaR MG2er
kinetic law: MODEL1310110015#
reversible: false
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
fast: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_482fd236_f2c0_4527_acfd_d9453ed6783e
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:518
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
type: Species
boundary condition: true
initial amount: NaN

metaM ksi pre7 g
has only substance units: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: C00130
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 7
is: SBO:0000247
type: Species

metaM CE2705 c
initial concentration: 1.0
is: CHEBI:36781
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: quinonoid dihydrobiopterin
type: Species

metaR DCYTDn
fast: false
name: deoxycytidine deaminase, nuclear
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false

metaM 2mop c
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01172
is: CHEBI:57700
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
is: SBO:0000247
type: Species
name: 2-methyl-3-oxopropanoate

metaR URAt
fast: false
product: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR MALtm
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
type: Reaction
modifier: MODEL1310110015#
is: SBO:0000185
name: malate transport, mitochondrial
fast: false
product: MODEL1310110015#

metaM 2octpencoa m
has only substance units: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
name: 2,6,9,12,15-octadecapentenoylcoa
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355

metaR r1678
is: SBO:0000185
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false

metaM fmn c
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: SBO:0000247
is: HMDB01520
is: CHEBI:58210
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00061
name: FMN
constant: false

metaM dutp n
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
is: HMDB01191
boundary condition: false
has only substance units: false
is: CHEBI:17625
constant: false
is: SBO:0000247
initial amount: NaN
name: dUTP
initial concentration: 1.0

metaR SADT
reactant: MODEL1310110015#
name: sulfate adenylyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110015#
fast: false
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction

metaR TCHOLAte
is: SBO:0000185
reactant: MODEL1310110015#
is described by: ECO:0000000
name: bile acid intracellular transport
reversible: true
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
type: Reaction

metaR ACACT1x
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000176
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110015#_8169d446_af82_4101_b75c_748de5e52eb8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
constant: false
has only substance units: false
name: PRDX2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_32e40249_4733_4354_9599_64fda97f5bb1
initial concentration: NaN
is: P06744
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2821
name: GPI
constant: false
initial amount: NaN
type: Species

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_37885f25_6e52_47b6_965d_a7fb78c99207
is: Q6NVY1
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:26275
initial amount: NaN
name: HIBCH
has only substance units: false
is: SBO:0000252

metaM acac x
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:13705
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
name: acetoacetate
type: Species
initial concentration: 1.0
constant: false

metaM dutp m
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: dUTP
is: SBO:0000247
is: HMDB01191

metaM HC02149 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:28867
is: SBO:0000247
type: Species
name: O-Propanoylcarnitine
has only substance units: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
initial amount: NaN

metaM pail5p hs c
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaM docohepcoa m
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
boundary condition: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_0048f5bc_a551_43a8_bc8e_e9d96a54fdaf
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: HAO1
is encoded by: hsa:54363
initial concentration: NaN
is: Q9UJM8
has only substance units: false
is: SBO:0000252

metaR ITCOALm
type: Reaction
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110015#
is: SBO:0000176
reversible: true
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR SR5ARr
kinetic law: MODEL1310110015#
type: Reaction
fast: false
product: MODEL1310110015#
is: SBO:0000176
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is version of: http://identifiers.org/ec-code/1.3.99.5

metaR B3GNT39g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110015#
is described by: ECO:0000000
fast: false

metaM ptth c
has only substance units: false
name: pantetheine
initial concentration: 1.0
boundary condition: false
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
is: SBO:0000247
is: CHEBI:16753
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_ef4aabc3_3ed1_4238_9783_faafccae9aa0
initial amount: NaN
type: Species
name: NT5C2
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:22978
is: P49902
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_7caba0c2_731b_46b0_ba3b_dd0dc3f21048
is encoded by: hsa:8566
name: PDXK
initial concentration: NaN
is: SBO:0000252
is: O00764
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC226C225m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM ksii core2 deg8 l
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 8
is: HMDB00143
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_d0eb7969_8520_4392_a2f9_eed21150dff3
boundary condition: true
name: DCK
type: Species
is: P27707
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:1633

metaM etfrd m
initial amount: NaN
has only substance units: false
notes: FORMULA: RH2 CHARGE: 0
name: Electron transfer flavoprotein reduced
is: HMDB00573
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:30825
is: SBO:0000247

metaM leuktrA4 e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: leukotriene A4(1-)
constant: false
type: Species
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463

http://identifiers.org/biomodels.db/MODEL1310110015#_2851c137_bda1_48dd_bc2f_c57d8120a0d4
type: Species
is: Q96C36
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29920
initial amount: NaN
initial concentration: NaN
constant: false
name: PYCR2

metaM m5masnC g
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:58401
is: SBO:0000247
notes: FORMULA: C52H87N2O40X CHARGE: 0
type: Species
initial concentration: 1.0
is: HMDB06814
has only substance units: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1b6b8483_f4ba_45a5_b9b7_577f5d836767
initial amount: NaN
name: CTSA
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5476
type: Species
constant: false
has only substance units: false
is: P10619
initial concentration: NaN

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM ksi pre32 g
name: keratan sulfate I biosynthesis, precursor 32
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110015#_ad44d7c7_7ba0_4d59_b3a6_357f60c1fb3d
constant: false
has only substance units: false
is encoded by: hsa:57678
name: GPAM
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q8N1G6

http://identifiers.org/biomodels.db/MODEL1310110015#_9f016d0d_65ad_4929_92c6_4a46929593d6
is: SBO:0000252
has only substance units: false
name: HSD17B10
is: Q99714
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:3028
constant: false
initial amount: NaN

metaM leuktrA4 c
initial concentration: 1.0
has only substance units: false
name: leukotriene A4(1-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
type: Species
is: HMDB01337
is: CHEBI:57463

metaR DITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction
product: MODEL1310110015#
name: dITP nuclear transport
reactant: MODEL1310110015#
reversible: true
fast: false

metaM ficytC m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Ferricytochrome c
boundary condition: false
is: CHEBI:15991
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
type: Species

metaR NH4tn
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
name: ammonia nuclear transport
kinetic law: MODEL1310110015#

metaR G16MT U
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
fast: false
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110015#_785eb8e1_066b_4a8c_b62c_f67318594300
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:389015
constant: false
is: Q6AI14
initial concentration: NaN
initial amount: NaN
name: SLC9A4

http://identifiers.org/biomodels.db/MODEL1310110015#_33fa7512_a71b_4782_ae18_11d05f076905
name: ATP5J
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:522
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM sphmyln hs c
has only substance units: false
constant: false
is: HMDB02704
is: CHEBI:21338
initial amount: NaN
type: Species
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
name: sphmyln_hs[c]
boundary condition: false

metaM dcacoa x
initial amount: NaN
is: C05274
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: HMDB06404
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: CHEBI:61430

http://identifiers.org/biomodels.db/MODEL1310110015#_f4a1ca61_a9ec_47b4_9bf4_b9076e86658b
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4125
is: SBO:0000252
type: Species
has only substance units: false
name: MAN2B1
is: O00754

http://identifiers.org/biomodels.db/MODEL1310110015#_1402a3f4_63a6_494c_a4fb_e43c854c9155
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: PGAP1
is encoded by: hsa:80055
is: Q75T13
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_e74eebd2_6163_40b6_91f0_e5dde217c7df
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3032
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: HADHB
is: P55084
type: Species

metaR r0443
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: false
type: Reaction
fast: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR UMPKn
is: SBO:0000176
reactant: MODEL1310110015#
name: UMP kinase, nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR r2088
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110015#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
type: Reaction

metaR URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.49
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
name: URCN
type: Reaction
fast: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM 3dodtricoa m
type: Species
is: HMDB03952
initial concentration: 1.0
constant: false
has only substance units: false
is: C05280
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 3,6,9-dodecatrienoylcoa
is: SBO:0000247

metaM CE5118 m
is: CHEBI:57923
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_4de7d82f_f81b_4332_b8dc_d1e3d10218e3
constant: false
name: NAGLU
initial amount: NaN
is encoded by: hsa:4669
initial concentration: NaN
has only substance units: false
type: Species
is: P54802
is: SBO:0000252
boundary condition: true

metaR NH4tp
product: MODEL1310110015#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#
name: ammonia peroxisomal transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM s2l2n2m2masn e
name: de-Fuc form of PA6
boundary condition: false
has only substance units: false
constant: false
is: C00255
initial amount: NaN
is: HMDB00244
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110015#_f98dfc7c_1e41_4e50_9f2e_9ba4b8296527
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:9963
name: SLC23A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_f2093995_3371_423b_854e_585c4d60af9e
is encoded by: hsa:3550
type: Species
boundary condition: true
is: Q13123
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: IK
has only substance units: false
constant: false

metaR 3HBCOAHLm
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110015#_1384a268_1201_4471_a36b_69321a36406d
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O00400
constant: false
initial amount: NaN
name: SLC33A1
is encoded by: hsa:9197
type: Species
has only substance units: false

metaR H8TAer
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
product: MODEL1310110015#
name: H8 transamidase, endoplasmic reticulum
reversible: false
type: Reaction

metaR r2089
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaM HC02204 c
boundary condition: false
initial amount: NaN
is: CHEBI:27624
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cef777f9_5aca_4f55_ab98_cd56560a92d0
type: Species
boundary condition: true
is: O60427
is encoded by: hsa:3992
name: FADS1
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_c9806796_c161_43c6_a76e_d67eb79b1f2e
is: SBO:0000252
is encoded by: hsa:514
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110015#_248a6732_06df_4a40_8271_a7c70c8388d1
is encoded by: hsa:8869
initial amount: NaN
name: ST3GAL5
type: Species
is: Q9UNP4
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM accoa r
is: SBO:0000247
is: CHEBI:57288
constant: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
has only substance units: false
is: HMDB01206
boundary condition: false
type: Species
name: acetyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110015#_a53d4dfa_6e86_49dc_8125_ed9079e92786
boundary condition: true
name: PLCB1
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9NQ66
has only substance units: false
is encoded by: hsa:23236
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_4bc2ce3b_78fc_42a2_955b_5e1f1f064933
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: OGDH
boundary condition: true
is: B4E3E9
is encoded by: hsa:4967
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_e754bf21_cd45_4456_b1a4_b2ed2a03d392
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5625
is: O43272
name: PRODH
type: Species

metaR FAOXC15C13m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR r2086
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PPAm
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: false
name: inorganic diphosphatase
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110015#

metaR GLCNACASE5ly
product: MODEL1310110015#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110015#
reversible: false
reactant: MODEL1310110015#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

metaR r1682
reversible: false
type: Reaction
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#

metaR FAOXC221C201x
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR ABUTD
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
name: Aminobutyraldehyde dehydrogenase
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
type: Reaction
reactant: MODEL1310110015#

metaR MAL Lte
reactant: MODEL1310110015#
is described by: ECO:0000134
reversible: true
name: Transport of L-malate
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185

metaR r2087
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR DOCO13EFATP
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR G3PD1
fast: false
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is described by: ECO:0000269
type: Reaction
product: MODEL1310110015#
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.8
kinetic law: MODEL1310110015#
reversible: true

metaR G14T14g
product: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
reversible: true
modifier: MODEL1310110015#
is: SBO:0000185
fast: false
name: Hypoxanthine transport
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110015#_95b8a164_73a4_4763_bb32_c19315ae3ca3
is encoded by: hsa:8659
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ALDH4A1
is: P30038

metaR PACCOAL
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110015#
type: Reaction
name: phenylacetate-CoA ligase
reversible: false
reactant: MODEL1310110015#

metaM 3mob m
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
initial amount: NaN
type: Species
boundary condition: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00019
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5254c505_3c95_45b4_a8aa_00059f02fa2f
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q86V21
is encoded by: hsa:65985
name: AACS
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
name: RE3272
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM Rtotal3 e
type: Species
is: CHEBI:3554
constant: false
boundary condition: false
name: R total 3 position
initial concentration: 1.0
is: HMDB00244
has only substance units: false
initial amount: NaN
is: C00255
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1

metaR r2084
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
reversible: true
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM ethamp c
constant: false
type: Species
is: HMDB00224
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: ethamp[c]
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110015#_d4072147_b6d6_466c_beba_c7fd3efe161c
name: ATP1B2
constant: false
is: P14415
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:482
is: SBO:0000252

metaM 12ppd S c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (S)-propane-1,2-diol
is: CHEBI:29002
is: HMDB06213
is: SBO:0000247
boundary condition: false
constant: false

metaR ACACT1r
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
name: acetyl-CoA C-acetyltransferase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#

metaR RE3627M
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE3627
fast: false
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM accoa m
name: Acetyl-CoA
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: CHEBI:57288
is: C00024
has only substance units: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1a27f69c_4ea2_40da_bce7_5c9018c0e027
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:218
name: ALDH3A1
is: P30838
type: Species
has only substance units: false

metaR GLYt7 311 r
is: SBO:0000185
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
fast: false
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006

metaM cdp c
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
name: CDP
initial amount: NaN
is: C00112
has only substance units: false
is: HMDB01546
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_38076e13_c657_4298_a571_792e89daa35a
constant: false
initial amount: NaN
type: Species
is: Q16790
is: SBO:0000252
name: CA9
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:768

http://identifiers.org/biomodels.db/MODEL1310110015#_4cd36922_8bfa_4533_ae20_05dfe8f927c6
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:8897
constant: false
initial concentration: NaN
name: MTMR3
initial amount: NaN
is: SBO:0000252

metaR RE3367E
reactant: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
name: RE3367
kinetic law: MODEL1310110015#
fast: false
type: Reaction

metaR r2085
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM ksii core4 pre4 g
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:58053
initial concentration: 1.0
type: Species
notes: FORMULA: C61H99N5O43X CHARGE: -1
constant: false
is: C00130
is: HMDB00175
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM pcrn x
is: SBO:0000247
is: HMDB00824
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738

metaR FAOXC101C102m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR HMGLx
reversible: false
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110015#

metaR RE3006M
reversible: true
name: RE3006
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM m1mpdol U c
initial concentration: 1.0
constant: false
is: CHEBI:28067
boundary condition: false
is: SBO:0000247
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110015#_af32d361_72b7_4fb7_b5c3_0803e2448f99
is encoded by: hsa:2653
constant: false
initial amount: NaN
type: Species
name: GCSH
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P23434

metaM 5eipencoa m
has only substance units: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 5,8,11,14,17-eicosapentenoylcoa

metaR 10FTHFtm
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185

metaR UGCG
modifier: MODEL1310110015#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.80
is: SBO:0000176
fast: false
product: MODEL1310110015#
name: Ceramide glucosyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_dc57ab4a_dcfe_44bc_8bb9_46b876f9ed83
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9H008
name: LHPP
boundary condition: true
is encoded by: hsa:64077
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_b9671e50_4f65_463a_94a9_08bf22e66f1f
constant: false
is encoded by: hsa:AI620219
initial concentration: NaN
has only substance units: false
name: _AI620219_1_e
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM accoa n
initial concentration: 1.0
name: acetyl-CoA(4-)
is: HMDB01206
is: CHEBI:57288
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR CTPtn
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
name: CTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#

metaM pristcoa c
name: pristanoyl coa
is: CHEBI:51341
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_714d9b43_32a1_4f9d_84ad_9f41d34b5a2c
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79053
boundary condition: true
name: ALG8
has only substance units: false
is: A6NDW6

http://identifiers.org/biomodels.db/MODEL1310110015#_6fe95204_0c71_4b64_97e9_a33365205ca2
boundary condition: true
name: NUDT12
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:83594
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9BQG2

metaM HC00361 c
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: SBO:0000247
is: CHEBI:58335

http://identifiers.org/biomodels.db/MODEL1310110015#_9850b440_4519_478d_a089_fe027b213c26
is: B2RAT6
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: GALT
type: Species
initial amount: NaN
is encoded by: hsa:2592
boundary condition: true

metaR OMPDC
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110015#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110015#
modifier: MODEL1310110015#

metaR ADEt
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
fast: false
kinetic law: MODEL1310110015#
name: adenine reversible transport, cytosol
modifier: MODEL1310110015#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_49bfc6cd_ed1d_48e2_bbc3_f1d1058762da
has only substance units: false
has part: P55084
name: HADHA:HADHB
is encoded by: hsa:3030
type: Species
constant: false
has part: E9KL44
initial amount: NaN
is encoded by: hsa:3032
is: SBO:0000297
boundary condition: true
initial concentration: NaN

metaR r0441
kinetic law: MODEL1310110015#
is: SBO:0000176
fast: false
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM m8masn r
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR GLNtN1
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000269
name: Glutamine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false

metaM nicrnt c
name: Nicotinate D-ribonucleotide
is: HMDB01132
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
is: SBO:0000247
is: CHEBI:57502
is: C01185
has only substance units: false
boundary condition: false

metaM cdp e
has only substance units: false
type: Species
is: CHEBI:58069
initial amount: NaN
boundary condition: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR PROSTGH2t
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
product: MODEL1310110015#
is: SBO:0000185

metaR ASPTAm
product: MODEL1310110015#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110015#
name: aspartate transaminase
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110015#

metaR r2083
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR PTRCOX1
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000304
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
product: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
reversible: false
reactant: MODEL1310110015#
name: Putrescine:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22

http://identifiers.org/biomodels.db/MODEL1310110015#_26276aba_7dcb_41fd_8680_60b2fe4ee54a
constant: false
is: SBO:0000252
name: _AI971036_1_x
is encoded by: hsa:AI971036
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaM bilglcur e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57767
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110015#_14b65207_eeb5_4241_b761_401f29f3936d
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: XDH
is encoded by: hsa:7498
is: P47989
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cafeaa5e_8de3_44a6_b11e_3cb048254683
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: _HG2846_HT2983_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_b79ad1eb_8763_4b54_adca_48fa9639e0ee
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4357
is: SBO:0000252
has only substance units: false
is: P25325
name: MPST
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_7f29413d_a0c8_42e2_9b78_38c5a4f0f2a3
name: CYB5D1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q6P9G0
is encoded by: hsa:124637
constant: false
type: Species

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_4b451a5c_d6c4_471d_aa8d_df1456af677b
is encoded by: hsa:AI435857
boundary condition: true
initial concentration: NaN
constant: false
name: _AI435857_1_x
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_acc4cd47_0821_42a2_a338_d424f310281c
is: SBO:0000252
boundary condition: true
is: Q9NZK7
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:30814
name: PLA2G2E

metaM dump c
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
initial concentration: 1.0
is: CHEBI:246422
constant: false
is: C00365
type: Species
is: HMDB01409
name: dUMP

http://identifiers.org/biomodels.db/MODEL1310110015#_f8dc423f_91f8_41fb_8198_d55a73edeea5
has part: P36957
is encoded by: hsa:1738
is: SBO:0000297
is encoded by: hsa:1743
initial amount: NaN
has part: Q02218
is encoded by: hsa:8050
is encoded by: hsa:4967
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: P09622
has part: O00330
constant: false
name: DLD:DLST:OGDH:PDHX
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_5adbd79e_2ed9_4c2f_9dce_5b30f34bcf6e
initial concentration: NaN
is: SBO:0000252
is: B4DUY1
type: Species
name: STARD3
boundary condition: true
constant: false
is encoded by: hsa:10948
initial amount: NaN
has only substance units: false

metaR ALOX5
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
name: Arachidonate 5-lipoxygenase
reversible: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_49a0be79_8fab_4469_8f22_8f00e97ffd30
initial amount: NaN
boundary condition: true
type: Species
name: ATP5J
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: P18859
is encoded by: hsa:522

metaR ORNt3m
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
fast: false
is described by: ECO:0000269
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
name: ornithine mitochondrial transport via proton antiport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_78af6cd6_44ad_42ac_8e67_d889d78aadd6
is encoded by: hsa:7084
is: O00142
is: SBO:0000252
initial amount: NaN
type: Species
name: TK2
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_253e1e0d_7ef6_4d73_b373_6d22c8948422
boundary condition: true
is encoded by: hsa:6184
type: Species
initial concentration: NaN
is encoded by: hsa:6185
is encoded by: hsa:1650
initial amount: NaN
is encoded by: hsa:1603
has part: P04843
has part: Q53G02
has only substance units: false
is: SBO:0000297
name: DAD1:DDOST:RPN1:RPN2
has part: P39656
constant: false
has part: P04844

metaR CRNt
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
name: L-carnitine reversible transport
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
fast: false
reversible: true

metaR r0596
fast: false
modifier: MODEL1310110015#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
product: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
reversible: false
is described by: ECO:0000000

metaR L LACt2r
reactant: MODEL1310110015#
name: L-lactate reversible transport via proton symport
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#

metaR r2193
type: Reaction
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110015#
is described by: ECO:0000000
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR 2HBO
is: SBO:0000176
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reactant: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
type: Reaction
fast: false
modifier: MODEL1310110015#

metaR r2080
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
reversible: true
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#

metaR NDPK10
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110015#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110015#
name: nucleoside-diphosphate kinase (ATP:dIDP)
fast: false

metaM ksi e
initial concentration: 1.0
name: keratan sulfate I
is: SBO:0000247
is: HMDB00211
type: Species
boundary condition: false
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
is: CHEBI:17268
has only substance units: false

metaR RDH1
reversible: true
name: retinol dehydrogenase (all-trans)
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
type: Reaction
is described by: ECO:0000269

metaM s2l2n2m2masn l
is: SBO:0000247
has only substance units: false
is: HMDB00174
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
name: de-Fuc form of PA6
type: Species
initial amount: NaN
is: CHEBI:18287
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_47f7da72_339a_4530_baf0_5a39c9ce1232
initial concentration: NaN
name: COX8A
type: Species
constant: false
boundary condition: true
is: Q53XN1
is encoded by: hsa:1351
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM bilglcur c
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
has only substance units: false
type: Species
initial concentration: 1.0

metaR ARABR
product: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
name: arabinose reductase
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2

metaM adrncoa c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A

metaR r2194
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_8d8d165a_d184_402c_b60b_8faceeee1873
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3290
boundary condition: true
type: Species
initial concentration: NaN
name: HSD11B1

http://identifiers.org/biomodels.db/MODEL1310110015#_b72b6878_de89_4fd6_90a1_e544081c6b08
is: SBO:0000252
initial amount: NaN
name: HAS3
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3038
constant: false
type: Species
is: O00219

http://identifiers.org/biomodels.db/MODEL1310110015#_c4ae9a8d_5edc_487d_bdda_a4615d438bed
name: ACSS2
boundary condition: true
is encoded by: hsa:55902
is: Q5QPH3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR r1969
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM ksii core4 deg2 l
is: HMDB00143
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 2
type: Species
boundary condition: false
is: CHEBI:12936
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C78H127N6O61S2X CHARGE: -2

metaM ksi deg36 l
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial amount: NaN
name: keratan sulfate I, degradation product 36

http://identifiers.org/biomodels.db/MODEL1310110015#_d7524b1a_38fc_42ce_bc96_3b5141c1582f
initial amount: NaN
is encoded by: hsa:1719
has only substance units: false
type: Species
name: DHFR
boundary condition: true
is: P00374
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d79f1f79_fbbb_4efa_b29e_3f679a2e802b
is: SBO:0000252
is encoded by: hsa:1666
has only substance units: false
initial concentration: NaN
name: DECR1
initial amount: NaN
boundary condition: true
constant: false
is: Q16698
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR HMGLm
type: Reaction
reactant: MODEL1310110015#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110015#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
product: MODEL1310110015#

metaM accoa x
initial concentration: 1.0
is: SBO:0000247
name: Acetyl-CoA
initial amount: NaN
is: C00024
boundary condition: false
is: CHEBI:57288
constant: false
is: HMDB01206
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_822bb430_0c9a_4877_ad22_a8b84e90cb24
name: SDHB
is encoded by: hsa:6390
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P21912
constant: false

metaR RDH3
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
name: retinol dehydrogenase (11-cis,NADH)
type: Reaction
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM CE2435 m
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: CHEBI:57795

metaR CSNATm
reversible: true
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: carnitine O-aceyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
product: MODEL1310110015#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_ec263ef9_ec48_42bd_aabe_879c818b9001
is encoded by: hsa:412
initial amount: NaN
is: P08842
name: STS
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM s7p c
type: Species
is: SBO:0000247
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
initial amount: NaN
boundary condition: false
is: HMDB01068
name: Sedoheptulose 7-phosphate
constant: false
is: C05382
has only substance units: false
is: CHEBI:57483
initial concentration: 1.0

metaR RTOTAL2FATPc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM m8masn g
initial amount: NaN
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6a5c076f_1fe5_4828_ac8a_5f8e76015f47
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5281
is: SBO:0000297
name: PIGF:PIGO
initial amount: NaN
has only substance units: false
has part: Q07326
is encoded by: hsa:84720
has part: Q8TEQ8

http://identifiers.org/biomodels.db/MODEL1310110015#_8110c3a4_daaf_4a8f_900c_c7769359ef46
initial concentration: NaN
has only substance units: false
is: Q53HE2
name: TPI1
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:7167
constant: false

metaR S4TASE2ly
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_0f4137f3_b943_4a05_ab83_ba8413899bb9
is: Q9Y619
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: SLC25A15
is encoded by: hsa:10166
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR GALU
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.9
fast: false
is described by: ECO:0000134
is: SBO:0000176
name: UTP-glucose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
type: Reaction
reactant: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_aa6962cb_32cf_4acc_aad9_b60e44b8a606
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI631997
type: Species
name: _AI631997_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2197
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reversible: true
type: Reaction
is: SBO:0000185

metaR SMPD4
is described by: ECO:0000000
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
is: SBO:0000176
name: sphingomyelinase
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false

metaM gar c
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02022
is: CHEBI:58457
name: N1-(5-Phospho-D-ribosyl)glycinamide
type: Species
is: C03838

http://identifiers.org/biomodels.db/MODEL1310110015#_86b306af_525d_47d2_99fd_78dc4c1da2db
is: P48163
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4199
name: ME1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

MODEL1310110015
species: metaM glyc R c
species: metaM pa hs n
reaction: metaR DNDPt10m
reaction: metaR EX tetpent6 LPAREN e RPAREN
reaction: metaR CYTD
species: metaM ura e
reaction: metaR AICART
reaction: metaR r1155
reaction: metaR LALDO2x
reaction: metaR r0629
reaction: metaR S6T14g
reaction: metaR RE3050R
species: metaM cmp c
species: metaM co2 c
reaction: metaR r2322
species: metaM HC01403 m
reaction: metaR r2439
reaction: metaR EX lnlncg LPAREN e RPAREN
species: metaM n2m2nmasn e
reaction: metaR GALASE5ly
reaction: metaR r2526
species: metaM cs b deg2 l
species: metaM L2aadp c
reaction: metaR PETOHMm hs
species: metaM sph1p e
species: metaM 34dhoxpeg c
reaction: metaR ITCOALm
species: metaM glyc m
reaction: metaR S6TASE9ly
reaction: metaR LNLNCGt
reaction: metaR NACHEX25ly
reaction: metaR ADK3
reaction: metaR FAOXC102C101m
reaction: metaR r0181
reaction: metaR r1602
reaction: metaR 34HPPte
reaction: metaR NACHEX16ly
reaction: metaR r0502
species: metaM utp e
reaction: metaR r1571
reaction: metaR r1428
reaction: metaR TKT1
species: metaM 20ahchsterol m
reaction: metaR LNLCCPT1
species: metaM 12ppd R c
species: metaM cs e deg5 l
reaction: metaR DURIPP
species: metaM cdp e
reaction: metaR EX maltttr LPAREN e RPAREN
species: metaM duri c
reaction: metaR SIAT9g
reaction: metaR AMETtd
reaction: metaR r1019
species: metaM drib e
reaction: metaR r0842
reaction: metaR MI145PP
reaction: metaR NACHEX22ly
reaction: metaR RE3269C
species: metaM idp e
species: metaM h2o2 m
reaction: metaR r0129
reaction: metaR FAOXC184m
reaction: metaR AIRCr
reaction: metaR r2108
reaction: metaR NTP3e
species: metaM omhdecacid c
reaction: metaR SFGTH
species: metaM HC00591 c
reaction: metaR r1670
species: metaM thcholstoic c
reaction: metaR DOLPMT4 Uer
species: metaM crn x
reaction: metaR ENGASE3ly
reaction: metaR EX glc LPAREN e RPAREN
species: metaM xol7ah3 c
species: metaM ahdt e
reaction: metaR FAOXC13C11m
species: metaM homoval m
reaction: metaR r0633
reaction: metaR CYTK2n

metaR 1PPDCRp
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
product: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
reversible: false

metaM 3mob c
name: 3-methyl-2-oxobutanoate
constant: false
is: HMDB00019
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:11851

metaM cit m
boundary condition: false
has only substance units: false
is: C00158
is: CHEBI:16947
is: SBO:0000247
constant: false
name: Citrate
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
type: Species
is: HMDB00094

metaR GALT
is: SBO:0000176
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110015#
name: galactose-1-phosphate uridylyltransferase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
modifier: MODEL1310110015#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#

metaR r2198
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110015#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_48b15c29_7570_4c83_8fbd_9d5e3bf5e315
constant: false
name: AGPAT1
is: Q99943
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10554
has only substance units: false

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_566ceea7_d776_49fc_99aa_2eda536b6f1b
constant: false
is: Q9Y672
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:29929
initial concentration: NaN
name: ALG6

metaM 2docopencoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 2,7,10,13,16-docosapentenoylcoa
type: Species
boundary condition: false
initial amount: NaN

metaR SPMS
is version of: http://identifiers.org/ec-code/2.5.1.16
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
name: spermidine synthase
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
reversible: false
type: Reaction
fast: false

metaM cdp m
is: SBO:0000247
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:58069
initial amount: NaN
is: HMDB01546

metaR RE1521M
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110015#
name: RE1521
is: SBO:0000176
modifier: MODEL1310110015#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_95bb2a0a_3a4d_4315_9817_d933b150c4e3
is encoded by: hsa:AI222095
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: _AI222095_1_e
is: SBO:0000252

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
constant: false
is: CHEBI:29991
is: SBO:0000247
has only substance units: false
boundary condition: false
name: L-aspartate(1-)
initial concentration: 1.0
is: HMDB00191
type: Species

metaR FACOAL170
fast: false
reactant: MODEL1310110015#
name: fatty-acid--CoA ligase
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR TPI
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110015#
name: triose-phosphate isomerase
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/5.3.1.1
type: Reaction
fast: false

metaR HISD
kinetic law: MODEL1310110015#
reversible: false
name: histidase
product: MODEL1310110015#
is described by: ECO:0000269
reactant: MODEL1310110015#
fast: false
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is version of: http://identifiers.org/ec-code/4.3.1.3
is: SBO:0000176

metaR r2195
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110015#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR PRFGS
modifier: MODEL1310110015#
product: MODEL1310110015#
name: phosphoribosylformylglycinamidine synthase
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.3.5.3
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR CSNATp
reversible: true
reactant: MODEL1310110015#
is: SBO:0000176
fast: false
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110015#
product: MODEL1310110015#
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is described by: ECO:0000304

metaR RE1448N
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
name: RE1448

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR LSTO2r
modifier: MODEL1310110015#
name: Lathosterol oxidase
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
fast: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.14.21.6
reactant: MODEL1310110015#
reversible: false
is described by: ECO:0000269
product: MODEL1310110015#
type: Reaction
is: SBO:0000176

metaM CE2839 e
is: C01936
constant: false
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: maltodecaose
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

metaM 3mob e
is: HMDB00019
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851
constant: false

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false

metaM ksi deg22 l
type: Species
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
name: keratan sulfate I, degradation product 22
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN
boundary condition: false
is: HMDB00812

metaR PPCOACm
name: Propionyl-CoA carboxylase, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.3
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
reversible: false
is: SBO:0000176

metaR r1791
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9f12b5b4_95cc_4aad_b5cb_a9f68ad24241
is encoded by: hsa:2530
is: G3V5N0
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: FUT8

metaR r2196
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
fast: false

metaR RE1530C
name: RE1530
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110015#

metaR RE2666C
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: RE2666
is described by: ECO:0000000
reversible: false
fast: false

metaR 4ABUTtcn
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
is described by: ECO:0000134
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
name: transport of GABA
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_737758a6_a868_4076_bc05_fd840f64a436
has only substance units: false
type: Species
constant: false
is encoded by: hsa:518
initial concentration: NaN
is: SBO:0000252
name: ATP5G3
initial amount: NaN
boundary condition: true

metaM ppi c
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00250
initial amount: NaN
is: SBO:0000247
is: CHEBI:0
is: C00013
boundary condition: false
type: Species

metaR r1646
reactant: MODEL1310110015#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_e4fc4db1_e733_4a33_95d4_72893cd504e8
is encoded by: hsa:206
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: _206_1_c

http://identifiers.org/biomodels.db/MODEL1310110015#_fca7d767_610d_4909_97be_d71a94c87a8b
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI601100
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: _AI601100_1_m

metaR THBPT4ACAMDASE
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
product: MODEL1310110015#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110015#

metaM damp c
is: SBO:0000247
is: CHEBI:58245
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: HMDB00905
name: dAMP(2-)
constant: false
initial amount: NaN

metaM apoC Lys btn m
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false
has only substance units: false
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: C05552
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_d661fa98_3a67_4af4_9127_705f81c65aa2
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:341947
is: Q7Z4L0
boundary condition: true
name: COX8C
is: SBO:0000252

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_b81fa510_9f36_48ba_a583_676e759fae08
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:347734
constant: false
boundary condition: true
is: Q8TB61
has only substance units: false
name: SLC35B2

metaM cspg e l
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
constant: false
type: Species
is: HMDB02183
initial concentration: 1.0
is: CHEBI:36005
boundary condition: false
has only substance units: false

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1b8d9c7b_3aa7_4ab9_866b_0bf4035ea201
initial amount: NaN
is: P49189
initial concentration: NaN
is encoded by: hsa:223
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: ALDH9A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_edf9aa9f_94a7_46aa_802b_d3e8035a2d1a
constant: false
initial concentration: NaN
boundary condition: true
is: Q15067
initial amount: NaN
has only substance units: false
is encoded by: hsa:51
type: Species
name: ACOX1
is: SBO:0000252

metaR S6TASE12ly
modifier: MODEL1310110015#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110015#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110015#

metaR r1647
is: SBO:0000185
type: Reaction
reactant: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM retinal cis 9 c
has only substance units: false
is: HMDB01358
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: all-trans-retinal
is: CHEBI:17898
initial amount: NaN

metaR r0594
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110015#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000000

metaM ppi e
constant: false
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
boundary condition: false
is: HMDB00250
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: C00013
is: CHEBI:33019

metaR GPDDA1
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110015#
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_99c57c65_2c87_4f9b_8bcc_b13ead7240eb
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: GAMT
initial amount: NaN
is encoded by: hsa:2593
type: Species
initial concentration: NaN

metaR NORANMT
reactant: MODEL1310110015#
name: noradrenaline N-methyltransferase
product: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.28
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: false
type: Reaction

metaR FAOXC2452256x
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM cs e deg1 l
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
is: SBO:0000247
is: HMDB00868
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
type: Species
boundary condition: false

metaR FAOXC140
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR r1644
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110015#
type: Reaction

metaM 3spyr c
is: HMDB04045
boundary condition: false
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
is: CHEBI:57940
type: Species
has only substance units: false
constant: false
name: 3-sulfonatopyruvate(2-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_0d1a1b5e_8aba_4ddc_b92d_507b0b78c3d4
name: CPT1B
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1375
is: B7Z5T8
initial amount: NaN
boundary condition: true

metaR GALASE3ly
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
modifier: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000176
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_c203010c_c18a_41b9_9303_fe668a647f93
has only substance units: false
type: Species
is: B7Z6M3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8525
constant: false
boundary condition: true
is: SBO:0000252
name: DGKZ

metaR RE3243R
modifier: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110015#
fast: false
name: RE3243
reactant: MODEL1310110015#

metaM thbpt4acam c
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15374
boundary condition: false
has only substance units: false
is: HMDB02281
is: SBO:0000247
type: Species
name: 4a-hydroxytetrahydrobiopterin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c853c1ce_bbb1_4619_8b44_bfc65c3b4832
has part: O60762
constant: false
boundary condition: true
has part: O94777
type: Species
is encoded by: hsa:8818
has part: Q86TM7
is: SBO:0000297
is encoded by: hsa:54344
initial amount: NaN
initial concentration: NaN
name: DPM3:DPM1:DPM2
is encoded by: hsa:8813
has only substance units: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR LEUKTRE4t
product: MODEL1310110015#
is described by: ECO:0000000
name: leukotriene E4 transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR MI1P Dtn
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
name: inositol 1-phosphate nuclear transport (diffusion)
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true

metaR RE1897C
reactant: MODEL1310110015#
is described by: ECO:0000000
name: RE1897
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reversible: true

metaR AG13T4g
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110015#
is described by: ECO:0000000

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r1645
reversible: true
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM ocdcea r
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
type: Species
is: C00712
name: octadecenoate (n-C18:1)
is: HMDB00207
constant: false
boundary condition: false

metaM crtsl r
type: Species
is: HMDB00063
is: CHEBI:17650
initial concentration: 1.0
constant: false
initial amount: NaN
name: cortisol
is: SBO:0000247
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_970cbd3f_21f0_4013_a3de_9b81f18036ba
type: Species
is: O95336
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PGLS
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:25796

metaR ACOAD9m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reactant: MODEL1310110015#
modifier: MODEL1310110015#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial

metaR TYRt
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
product: MODEL1310110015#
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM nrvnccoa c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
type: Species
boundary condition: false
name: nervonyl coenzyme A
constant: false
initial amount: NaN
is: C16532

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110015#
product: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110015#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110015#_6b2f97bb_e694_4feb_ae95_5cb30c9a0c26
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6576
is: D9HTE9
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLC25A1

http://identifiers.org/biomodels.db/MODEL1310110015#_70cced11_7a95_42f3_af6b_c946ada1081e
boundary condition: true
is encoded by: hsa:115286
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC25A26
type: Species
initial concentration: NaN
is: F8WAB8
has only substance units: false

metaR PI345P3P
product: MODEL1310110015#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
fast: false
reactant: MODEL1310110015#
reversible: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.3.67
kinetic law: MODEL1310110015#
is described by: ECO:0000000

metaR PUNP6
kinetic law: MODEL1310110015#
fast: false
reversible: true
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyinosine)
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110015#

metaM tettet6coa x
boundary condition: false
is: C16171
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
is: SBO:0000247
is: HMDB06516
type: Species
name: tetracosatetraenoyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110015#_e77351ce_f58a_4975_a7b9_a355b6ea2d9e
type: Species
has only substance units: false
is encoded by: hsa:55
name: ACPP
initial amount: NaN
boundary condition: true
is: P15309
is: SBO:0000252
initial concentration: NaN
constant: false

metaR BUTt2r
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
name: Butyrate transport via proton symport, reversible
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#
type: Reaction
modifier: MODEL1310110015#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_e2731f42_c10d_4ffb_806b_bff3352d18b7
name: COASY
has only substance units: false
is: SBO:0000252
is: Q13057
initial amount: NaN
type: Species
is encoded by: hsa:80347
constant: false
initial concentration: NaN
boundary condition: true

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_cbd1da8d_2fc9_4246_874a_cdb0d3cc9ba9
is: P00568
is encoded by: hsa:203
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: AK1
type: Species
constant: false

metaM cbasp e
type: Species
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00438
constant: false
is: HMDB00828
has only substance units: false
is: CHEBI:32814

http://identifiers.org/biomodels.db/MODEL1310110015#_558f6484_e7d6_4c37_a223_5f24970875eb
type: Species
boundary condition: true
is encoded by: hsa:125061
initial amount: NaN
initial concentration: NaN
constant: false
is: Q63HM1
is: SBO:0000252
name: AFMID
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_3839b456_29b7_4c66_80b6_381f8a5a35b9
initial amount: NaN
is: D3DX95
initial concentration: NaN
constant: false
name: CHAT
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103

metaR GUAPRT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
product: MODEL1310110015#
name: guanine phosphoribosyltransferase
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#

metaR C226COAtx
reversible: true
product: MODEL1310110015#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR PUNP7
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)

metaM udpglcur c
is: HMDB00935
initial concentration: 1.0
name: UDP-D-glucuronate
has only substance units: false
is: C00167
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:58052
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaR r0590
kinetic law: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000

metaM 3hbcoa R m
initial concentration: 1.0
is: CHEBI:57315
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01166
boundary condition: false
constant: false
name: (R)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN

metaR r1973
product: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#

metaR r1648
fast: false
is described by: ECO:0000000
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#

metaR HISTAtu
reactant: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport

metaM cdpchol c
boundary condition: false
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
initial amount: NaN
constant: false
is: HMDB01413
has only substance units: false
initial concentration: 1.0
type: Species
name: CDPcholine
is: CHEBI:16436
is: SBO:0000247

metaR NMNATr
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR PUNP4
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: true
name: purine-nucleoside phosphorylase (Deoxyguanosine)
product: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR DURIt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000185
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
product: MODEL1310110015#
reversible: true
type: Reaction

metaR AHEXASEly
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
product: MODEL1310110015#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r1972
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
fast: false
reversible: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR r1649
modifier: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
fast: false
reversible: true
product: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR UMPK5n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP),nuclear
product: MODEL1310110015#
is: SBO:0000176
reversible: true
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
type: Reaction

metaR EX pydam LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxamine
type: Reaction

metaM asp L c
is: SBO:0000247
name: L-aspartate(1-)
type: Species
boundary condition: false
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5b8aa3cb_e9df_4b2e_a027_4055f7811329
initial amount: NaN
initial concentration: NaN
is: O43488
constant: false
is encoded by: hsa:8574
has only substance units: false
name: AKR7A2
is: SBO:0000252
type: Species
boundary condition: true

metaM m3mpdol U c
initial amount: NaN
constant: false
is: CHEBI:37632
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
boundary condition: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20

metaM hyptaur c
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
is: HMDB00965
type: Species
is: SBO:0000247
name: Hypotaurine
initial concentration: 1.0
is: CHEBI:16668
boundary condition: false

metaM btcoa m
type: Species
initial concentration: 1.0
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
is: CHEBI:57371
name: Butanoyl-CoA
is: HMDB01088
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaM mhista c
is: SBO:0000247
type: Species
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58600
is: HMDB00898
name: N(tele)-methylhistaminium
boundary condition: false
has only substance units: false

metaR PUNP5
kinetic law: MODEL1310110015#
type: Reaction
reactant: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110015#
product: MODEL1310110015#
name: purine-nucleoside phosphorylase (Inosine)
is: SBO:0000176
reversible: true

metaR CSNATr
kinetic law: MODEL1310110015#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
type: Reaction
name: carnitine O-acetyltransferase
is: SBO:0000176

metaR r0113
modifier: MODEL1310110015#
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
reactant: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
reversible: false

metaM HC02023 r
is: CHEBI:46898
type: Species
has only substance units: false
boundary condition: false
constant: false
name: Cholesterol-ester-ol
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_3ad154e4_0262_43db_bc61_18a0e72bf1a1
name: _D87002_1_m
constant: false
type: Species
is encoded by: hsa:D87002
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
is: CHEBI:34939
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110015#_37373d3d_6734_4fbc_b41f_a4fd2bb6b430
name: SLC37A4
constant: false
is: A8K0S7
type: Species
is encoded by: hsa:2542
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR PDE1
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: MODEL1310110015#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
fast: false

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
boundary condition: false
is: CHEBI:32984
has only substance units: false
constant: false
initial concentration: 1.0
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
is: SBO:0000247
initial amount: NaN

metaM ksi deg11 l
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 11
has only substance units: false
constant: false
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_65bbd187_7dc1_4cc1_bc6b_60be23944898
is: P31350
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: RRM2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:6241

metaM 4nphsf c
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
name: 4-Nitrophenyl sulfate
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06492
initial concentration: 1.0

metaR r0480
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
reversible: true
kinetic law: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9e79dd4f_1cf6_4b74_acce_4b5ab5c846c0
is: Q8NB10
type: Species
is encoded by: hsa:5137
constant: false
initial amount: NaN
boundary condition: true
name: PDE1C
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_927cb3ae_1c4a_4ba8_a4d4_11f8e800d85b
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:56052
is: Q9BT22
constant: false
boundary condition: true
name: ALG1
initial concentration: NaN
initial amount: NaN

metaM 4hphac c
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
is: CHEBI:48999
has only substance units: false
is: HMDB00020
name: 4-hydroxyphenylacetate

http://identifiers.org/biomodels.db/MODEL1310110015#_587bae77_c15c_48d5_aaed_5bf1ceb494de
type: Species
has only substance units: false
is: P20020
name: ATP2B1
initial amount: NaN
is encoded by: hsa:490
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_584c7a62_a759_4f38_b1a1_4066bbc7cb88
boundary condition: true
is encoded by: hsa:AD000092
is: SBO:0000252
name: _AD000092_1_c
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR MANtly
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
reversible: false
name: mannose efflux from lysosome
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR KHK2
type: Reaction
fast: false
modifier: MODEL1310110015#
name: ketohexokinase (D-xylulose)
is version of: http://identifiers.org/ec-code/2.7.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110015#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM strdnc e
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
is: C16300
is: SBO:0000247
type: Species
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaM amp c
initial amount: NaN
boundary condition: false
is: C00020
is: SBO:0000247
is: CHEBI:3322
initial concentration: 1.0
name: AMP
type: Species
is: HMDB00045
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110015#_b7108e75_eaaf_4291_b1f1_a1cac1378f44
type: Species
name: BCMO1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:53630
has only substance units: false
is: Q9HAY6
constant: false

metaM accoa c
has only substance units: false
name: Acetyl-CoA
type: Species
constant: false
is: HMDB01206
is: C00024
is: CHEBI:57288
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_526d98a3_3cc3_4db2_8b70_272b11df37cc
initial amount: NaN
has only substance units: false
is: Q13011
constant: false
type: Species
boundary condition: true
name: ECH1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1891

metaM 4hphac e
initial amount: NaN
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
is: HMDB00020
is: CHEBI:48999
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM ppi m
has only substance units: false
is: C00013
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:33019
initial concentration: 1.0
constant: false
name: Diphosphate

http://identifiers.org/biomodels.db/MODEL1310110015#_c1c262a0_aeb9_4e0c_8be2_0ea7cd771e43
has only substance units: false
initial amount: NaN
constant: false
is: A3KLL5
is: SBO:0000252
name: ATP1B1
is encoded by: hsa:481
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_3c6d5690_ca54_47bc_a5da_1c3ecae96ae4
initial amount: NaN
is encoded by: hsa:2108
type: Species
is: P13804
initial concentration: NaN
is: SBO:0000252
constant: false
name: ETFA
has only substance units: false
boundary condition: true

metaM apoC Lys btn c
is: CHEBI:32551
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB00182
boundary condition: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR EX doco13ac
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR DOLPGT1 Uer
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reversible: false
modifier: MODEL1310110015#
is described by: ECO:0000000
fast: false
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.267
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR AICART
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110015#
type: Reaction
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

http://identifiers.org/biomodels.db/MODEL1310110015#_8cb94100_6d5c_48f9_9ac3_0a60581ddeb8
type: Species
is: SBO:0000252
name: PIGB
boundary condition: true
initial amount: NaN
is: Q92521
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:9488

metaR r1377
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaM 4nphsf e
initial concentration: 1.0
is: CHEBI:35422
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
name: 4-Nitrophenyl sulfate
has only substance units: false
boundary condition: false
is: HMDB06492

http://identifiers.org/biomodels.db/MODEL1310110015#_8c64f061_dc0a_4697_90c1_3f3e0b57bac5
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM ksi deg3 l
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate I, degradation product 3
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: HMDB00573
initial concentration: 1.0
is: CHEBI:30825

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: CHEBI:59905
is: HMDB00073
is: SBO:0000247
name: dopaminium(1+)
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR S6TASE21ly
fast: false
kinetic law: MODEL1310110015#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110015#
type: Reaction
reversible: true
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110015#_1afd9097_5624_4f37_9faa_c5e23e37f8f1
type: Species
constant: false
is encoded by: hsa:6532
is: SBO:0000252
has only substance units: false
name: SLC6A4
is: P31645
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_42912580_49fc_49e2_84b6_00fd6f312921
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: P33908
name: MAN1A1
is encoded by: hsa:4121
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR TMDPK
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110015#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000176
fast: false
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reversible: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110015#

metaM hmgcoa x
type: Species
is: CHEBI:15467
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
is: HMDB01375

metaM amp e
is: HMDB00045
type: Species
is: CHEBI:456215
constant: false
is: C00020
name: AMP
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR KCC2t
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110015#

metaM strdnc c
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
is: HMDB06547
is: C16300
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1378
fast: false
product: MODEL1310110015#
reversible: true
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_5ce6637f_85a6_4f59_a46c_8a3d713d980a
constant: false
boundary condition: true
name: ST20
is encoded by: hsa:400410
is: SBO:0000252
is: Q9HBF5
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR XYLTD Dr
reversible: true
name: xylitol dehydrogenase (D-xyulose-forming)
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110015#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110015#
reactant: MODEL1310110015#

metaM 3hbcoa R c
constant: false
initial amount: NaN
name: (R)-3-hydroxybutanoyl-CoA(4-)
type: Species
is: HMDB01166
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM 2maacoa m
boundary condition: false
has only substance units: false
initial amount: NaN
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
is: HMDB01157
is: SBO:0000247
constant: false
is: CHEBI:57335
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_ef2d8861_da9a_48a1_94a2_fbfff30cd378
boundary condition: true
initial amount: NaN
is encoded by: hsa:4907
name: NT5E
has only substance units: false
constant: false
type: Species
is: P21589
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_1dd68021_e314_4d18_a857_7f8f985e2b8e
initial amount: NaN
initial concentration: NaN
constant: false
name: DEGS1
is encoded by: hsa:8560
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_548aeefe_9530_4e1e_8d98_872923fe7957
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8613
is: SBO:0000252
type: Species
name: PPAP2B
is: O14495
has only substance units: false

metaR FAOXTC101TC102m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR HS1ly
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false

metaR r1642
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110015#

metaR r0698
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.2.27
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
type: Reaction
is: SBO:0000176
reversible: true

metaM ksii core4 deg3 l
boundary condition: false
type: Species
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00143

metaR IDHPOXOXb
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) SUBSYSTEM: Tyrosine metabolism EC Number: 1.11.1.8 Confidence Level: 4 AUTHORS: PMID:2997169,PMID:3153466,PMID:3475693 NOTES:SAB different because now HI = H + I due to pKa of -10
is version of: http://identifiers.org/ec-code/1.11.1.8
reversible: false
name: Iodide:hydrogen-peroxide oxidoreductase
is described by: ECO:0000269
modifier: MODEL1310110015#
type: Reaction
fast: false
reactant: MODEL1310110015#
is: SBO:0000176

metaR 4HOXPACDOX NADP
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110015#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
product: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction

metaR ALAtN1
fast: false
name: Alanine transport (Na, H coupled)
product: MODEL1310110015#
is: SBO:0000185
modifier: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269

metaM dopa e
boundary condition: false
is: CHEBI:59905
is: HMDB00073
initial amount: NaN
is: SBO:0000247
constant: false
name: dopaminium(1+)
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758

metaR GLCNACASE2ly
reactant: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false

metaM pre prot r
is: SBO:0000247
boundary condition: false
is: CHEBI:16240
notes: FORMULA: XY CHARGE: 0
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species
is: HMDB03125
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_5ef0466a_517c_485a_93df_f55eb66bdbab
initial concentration: NaN
type: Species
name: _AA081045_1_m
has only substance units: false
is encoded by: hsa:AA081045
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_aab5f22f_e6e7_492a_b460_77412accd1d0
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: PLCL1
is: Q15111
is encoded by: hsa:5334
initial concentration: NaN
is: SBO:0000252

metaM accoa g
initial concentration: 1.0
is: SBO:0000247
type: Species
name: acetyl-CoA(4-)
constant: false
is: CHEBI:57288
initial amount: NaN
boundary condition: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false

metaR r1643
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_28b1dbbb_9370_48d3_be13_fbc0bf1285b9
is: Q16774
initial concentration: NaN
name: GUK1
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2987
type: Species
constant: false
boundary condition: true

metaR r0276
is described by: ECO:0000000
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: true
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is: SBO:0000176
product: MODEL1310110015#
fast: false

metaR FAOXC123m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR HPDCACRNt
reversible: false
modifier: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: heptadecanoate transport into the mitochondria
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#

metaR UDPGALtg
type: Reaction
modifier: MODEL1310110015#
name: UDP-Gal Golgi transport via CMP antiport
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
fast: false

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: HMDB00250
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:33019
name: diphosphate(3-)
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM ksi pre13 g
name: keratan sulfate I biosynthesis, precursor 13
has only substance units: false
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130

metaM 3dhguln c
has only substance units: false
name: 3-dehydro-L-gulonate
is: CHEBI:57655
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06334
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1

metaR r1640
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_c5e90cb9_e5dc_46b5_8633_2ed5a95ebf1b
initial amount: NaN
has only substance units: false
constant: false
name: PKM2
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5315
boundary condition: true

metaR RPEc
is described by: ECO:0000134
product: MODEL1310110015#
reactant: MODEL1310110015#
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
fast: false
is: SBO:0000176
reversible: true
type: Reaction

metaR PYK
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
name: pyruvate kinase
is: SBO:0000176
modifier: MODEL1310110015#
product: MODEL1310110015#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false

metaR NACHEX2ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#

metaR LEUKTRB4t
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
reversible: true
name: leukotriene B4 transport

metaR RE2974C
reversible: true
modifier: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
fast: false
name: RE2974
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.149
kinetic law: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:

metaR AGPAT1
kinetic law: MODEL1310110015#
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
is version of: http://identifiers.org/ec-code/2.3.1.15
is described by: ECO:0000000
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
product: MODEL1310110015#
fast: false

metaR r1641
kinetic law: MODEL1310110015#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#

metaR r0483
reactant: MODEL1310110015#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_9fe0f58c_92ca_48cc_8dc2_96c2c7228029
initial concentration: NaN
type: Species
is encoded by: hsa:85365
boundary condition: true
name: ALG2
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM ksi deg18 l
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
name: keratan sulfate I, degradation product 18
is: HMDB00143
constant: false
is: CHEBI:12936
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM 4hglusa m
is: CHEBI:27809
constant: false
is: SBO:0000247
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06556

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR MTHFD2m
reversible: true
product: MODEL1310110015#
is: SBO:0000176
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is described by: ECO:0000254
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9

http://identifiers.org/biomodels.db/MODEL1310110015#_b9942423_65d4_4ab1_bd09_c5b388f8ee60
has only substance units: false
name: PLA2G2D
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:26279
boundary condition: true
initial concentration: NaN
is: Q9UNK4

metaM vitd3 c
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: calciol
has only substance units: false
initial amount: NaN
is: HMDB00876
is: CHEBI:28940

metaM 5adtststerones e
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
is: HMDB06278

metaM ocdcea c
has only substance units: false
initial amount: NaN
type: Species
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: CHEBI:0
constant: false
boundary condition: false
is: HMDB00207
is: SBO:0000247

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16953
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB00812
boundary condition: false

metaR RE3626M
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110015#
product: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
modifier: MODEL1310110015#
name: RE3626

http://identifiers.org/biomodels.db/MODEL1310110015#_fa96aeae_bbca_4dd8_8fe1_7e28e16aeca0
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55967
is: F8VQS7
boundary condition: true
constant: false
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110015#_28ed4b59_23dc_4bef_a69f_d7452ade5514
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5290
name: PIK3CA:PIK3R2
initial amount: NaN
has only substance units: false
has part: P42336
is: SBO:0000297
has part: O00459
is encoded by: hsa:5296

metaR MAOX
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110015#
name: Methylamine oxidase
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000304
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110015#_99287ec7_893d_4376_9d9e_8205ebc37d25
is: SBO:0000252
is: Q9UBF8
is encoded by: hsa:5298
constant: false
initial concentration: NaN
name: PI4KB
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM ksi pre31 g
is: CHEBI:58053
is: HMDB00175
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
initial concentration: 1.0
is: C00130
notes: FORMULA: C227H363N16O189S9X CHARGE: -10

metaR FAOXC183C163Gm
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
type: Reaction
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
fast: false
reversible: false
product: MODEL1310110015#

metaM pydx c
type: Species
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
name: Pyridoxal
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17310
is: HMDB01545
is: C00250
is: SBO:0000247
constant: false

metaR CHOLATEt
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110015#
type: Reaction
fast: false
reversible: true
name: cholate transport via bicarbonate countertransport

http://identifiers.org/biomodels.db/MODEL1310110015#_a945ff16_8dca_4f22_8550_66d303f84b9c
is: SBO:0000252
boundary condition: true
is: Q9NUB1
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:84532
name: ACSS1

http://identifiers.org/biomodels.db/MODEL1310110015#_ba79b5ae_4afb_4359_b12a_36964a17b374
is: Q6ZMU0
boundary condition: true
is encoded by: hsa:210
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: ALAD

metaR NACHEX27ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110015#
fast: false

metaR 34HPPOR
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110015#
reversible: false
kinetic law: MODEL1310110015#
fast: false

metaM amp m
is: HMDB00045
initial concentration: 1.0
is: CHEBI:456215
name: AMP(2-)
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
boundary condition: false
initial amount: NaN

metaR S4TASE5ly
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110015#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
fast: false

metaR TSTSTERONEtr
fast: false
name: testosterone intracellular transport
reactant: MODEL1310110015#
reversible: true
kinetic law: MODEL1310110015#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185

metaM ocdcea e
name: octadecenoate (n-C18:1)
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00207
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
is: CHEBI:0
type: Species

metaM tettet6coa c
is: http://identifiers.org/pubchem.compound/47205481
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
type: Species
is: HMDB06516
is: C16171
name: tetracosatetraenoyl coenzyme A
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaM acgal l
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
is: CHEBI:28037
initial concentration: 1.0
is: HMDB00212

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_2671791c_b735_4132_8ce8_5c82389379d0
is encoded by: hsa:1340
name: COX6B1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: P14854
initial concentration: NaN

metaR FAOXC6C4m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_38e5f514_2221_4a68_a2b5_538883c74284
constant: false
boundary condition: true
name: ADH1C
is: SBO:0000252
is encoded by: hsa:126
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P00326

http://identifiers.org/biomodels.db/MODEL1310110015#_d04c97eb_615d_438c_a838_64f9c8c6a997
type: Species
is: P16219
initial amount: NaN
is encoded by: hsa:35
initial concentration: NaN
constant: false
boundary condition: true
name: ACADS
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_e04d5a58_25b3_4469_8afc_89c1d11ee34c
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:57419
constant: false
name: SLC24A3
is: Q9HC58

metaR r0475
is described by: ECO:0000000
reversible: true
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
kinetic law: MODEL1310110015#
is: SBO:0000176

metaM CE4876 r
initial concentration: 1.0
name: delta12-Prostaglandin J2
constant: false
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial amount: NaN
has only substance units: false
is: HMDB01509
type: Species
is: CHEBI:57460
is: SBO:0000247

metaM glc D r
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
constant: false
is: HMDB00122
name: D-glucose
is: CHEBI:4167
is: SBO:0000247
initial amount: NaN

metaR ACt2r
is: SBO:0000185
kinetic law: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reactant: MODEL1310110015#
fast: false
type: Reaction
reversible: true
name: acetate reversible transport via proton symport
is described by: ECO:0000000

metaM malt e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: HMDB00163
type: Species
is: C00208
is: CHEBI:17306
name: Maltose
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM so3 m
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
initial amount: NaN
is: CHEBI:17137
name: hydrogensulfite
constant: false
is: HMDB00240
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
product: MODEL1310110015#
name: glyceraldehyde-3-phosphate dehydrogenase
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_9f42c672_6420_4ab2_9fc3_fec5187f5c3d
boundary condition: true
initial amount: NaN
has only substance units: false
is: P21953
name: BCKDHB
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:594
constant: false
type: Species

metaR FAOXC165C164m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaM 2obut m
type: Species
boundary condition: false
is: CHEBI:16763
constant: false
name: 2-oxobutanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
initial amount: NaN
is: SBO:0000247
is: HMDB00005
has only substance units: false
initial concentration: 1.0

metaM glygn4 e
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
boundary condition: false
initial amount: NaN
is: CHEBI:4167
has only substance units: false
notes: FORMULA: C18H31O16X CHARGE: 0
is: HMDB00122
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_7cc78508_79a8_43db_8667_7578bad47b87
has only substance units: false
initial amount: NaN
name: PTS
initial concentration: NaN
is: Q03393
boundary condition: true
type: Species
is encoded by: hsa:5805
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110015#_adde22f9_172b_4add_a370_63d2afdf20df
is encoded by: hsa:1103
initial amount: NaN
is: Q6LEN5
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110015#_54136635_2620_4cc7_bf0a_6900f4146b34
is: SBO:0000252
initial concentration: NaN
type: Species
is: B7Z3W8
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6536
name: SLC6A9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ea85f40c_da2e_4af3_94fa_8b01647a7c39
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: ALDH1L1
is encoded by: hsa:10840
is: O75891
initial concentration: NaN
has only substance units: false

metaR URATEt
is described by: ECO:0000000
name: urate export from cytosol
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: false
type: Reaction
fast: false
product: MODEL1310110015#

metaR FAOXC1811603m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110015#
product: MODEL1310110015#
name: Beta oxidation fatty acid
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
reactant: MODEL1310110015#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r0474
product: MODEL1310110015#
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110015#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction

metaM 1pyr5c m
is: C03912
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0
is: HMDB01301
is: CHEBI:15893
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_0800bebc_79f3_47eb_a794_5357db3be32e
name: ALDH1B1
type: Species
is encoded by: hsa:219
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: P30837
is: SBO:0000252
initial amount: NaN

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is encoded by: hsa:5295
has only substance units: false
has part: E7EX19
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: PIK3CD:PIK3R1

http://identifiers.org/biomodels.db/MODEL1310110015#_fbb859bb_9964_4aee_92cd_a48abf09c1a2
is: Q9H3H5
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: DPAGT1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1798
boundary condition: true

metaM glyc R c
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16659
name: D-glycerate
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_e4ac5fa6_fb31_4f2b_abb6_5ff39bbe4108
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:57282
name: SLC4A10
is: SBO:0000252
has only substance units: false
is: B7Z1R0

http://identifiers.org/biomodels.db/MODEL1310110015#_a337b9f1_35b4_417c_9b68_d3f22b0e0ca2
is: Q9H903
boundary condition: true
is: SBO:0000252
constant: false
name: MTHFD2L
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:441024
has only substance units: false
type: Species

metaM i c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB12238
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
name: iodide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_8e9b8271_f2ae_4a8d_98a8_56fbaeb06da2
is encoded by: hsa:145226
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: RDH12
constant: false
is: Q96NR8
initial concentration: NaN
has only substance units: false

metaR CPPPGO
kinetic law: MODEL1310110015#
name: coproporphyrinogen oxidase (O2 required)
product: MODEL1310110015#
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.3.3
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
is: SBO:0000176
modifier: MODEL1310110015#
reversible: false
fast: false
type: Reaction

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_61a881a1_7ac1_44b8_a903_1150f51fac9d
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P25705
has only substance units: false
name: ATP5A1
is encoded by: hsa:498
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_52652376_c1e6_49aa_a410_64e08137eb6b
has only substance units: false
boundary condition: true
type: Species
is: P53597
is encoded by: hsa:8802
is: SBO:0000252
constant: false
name: SUCLG1
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_dd2dd828_0e38_4251_9a8d_dd9ce5b83c5b
name: NT5C3
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9H0P0
is encoded by: hsa:51251
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_772300f5_1846_48fe_9505_1b9b596b23ad
type: Species
name: NT5C1B
boundary condition: true
constant: false
is: Q96P26
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:93034

metaM galgbside hs g
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:18259
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR RE3421R
reversible: true
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
fast: false
is: SBO:0000176
type: Reaction
name: RE3421
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_115229c4_5b2e_42a5_a21a_0b03371c193c
is encoded by: hsa:3425
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P35475
name: IDUA

metaM udpglcur r
initial amount: NaN
boundary condition: false
type: Species
name: UDP-D-glucuronate
is: HMDB00935
has only substance units: false
is: C00167
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
is: CHEBI:58052
initial concentration: 1.0

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR FAOXC102C81m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaM lneldccrn c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06461
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
has only substance units: false
type: Species
initial amount: NaN
name: Linoelaidyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110015#_95cba9a8_a86d_4c6e_8e05_79c1ab3b415d
is encoded by: hsa:57379
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: AICDA
type: Species
has only substance units: false
initial concentration: NaN
is: Q546Y9

metaM i e
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: iodide
boundary condition: false
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
is: CHEBI:16382
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a773012f_7cc0_4c90_8334_4fe080d71d31
is: Q9Y2A9
boundary condition: true
constant: false
name: B3GNT3
is encoded by: hsa:10331
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR GULNDer
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
name: gulonate dehydrogenase, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is: SBO:0000176

metaM pydam e
has only substance units: false
is: C00534
type: Species
name: Pyridoxamine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: CHEBI:57761
constant: false
is: SBO:0000247
is: HMDB01431
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_605fbd67_9259_43df_9451_77c2dedb6c9b
type: Species
name: TPI1P2
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:286016

http://identifiers.org/biomodels.db/MODEL1310110015#_165a54f6_c1f0_48b5_9325_aaf22675fdf9
type: Species
name: VNN1
has only substance units: false
constant: false
is: O95497
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8876
initial concentration: NaN

metaM HC02149 m
has only substance units: false
name: O-Propanoylcarnitine
is: CHEBI:28867
is: SBO:0000247
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110015#
name: RE1520
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM tddedicoa m
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN
name: trans3,6dodecadienoylcoa

metaM amp r
initial amount: NaN
type: Species
is: CHEBI:456215
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
is: HMDB00045
is: C00020
has only substance units: false
initial concentration: 1.0
name: AMP
boundary condition: false

metaM 5adtststerones c
is: HMDB06278
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM hs deg15 l
is: CHEBI:16126
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
is: SBO:0000247
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 15

metaM gthox c
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: C00127
is: HMDB03337
initial concentration: 1.0
is: CHEBI:58297
has only substance units: false
name: Oxidized glutathione
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

metaM spc hs c
is: http://identifiers.org/pubchem.compound/5311445
type: Species
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: sphingosylphosphorylcholine
constant: false
is: SBO:0000247

metaM L2aadp c
name: L-2-aminoadipate(1-)
constant: false
boundary condition: false
is: HMDB00510
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58672
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_890b1ff4_6cdd_4191_843b_e40183267c64
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:2747
type: Species
name: GLUD2
is: SBO:0000252
initial amount: NaN
is: P49448

metaR FAOXC205C185m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_3b5068ae_22b7_4271_bf72_86ec42f4e4b6
is: SBO:0000252
type: Species
boundary condition: true
is: P23109
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:270
initial concentration: NaN
name: AMPD1

http://identifiers.org/biomodels.db/MODEL1310110015#_e632c75d_a850_4d77_ab75_69923d7fdabe
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6PCB7
has only substance units: false
is encoded by: hsa:376497
boundary condition: true
name: SLC27A1

metaR MACACI
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
name: maleylacetoacetate isomerase
reversible: false

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaM dutp c
has only substance units: false
is: C00460
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
is: CHEBI:17625
is: HMDB01191
name: dUTP
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110015#_a05c18b7_61b1_4c14_853d_68593a323f55
is encoded by: hsa:8818
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: O94777
initial amount: NaN
name: DPM2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_a7a3f717_8689_412f_8570_bde77db2c529
name: ACAA2
constant: false
boundary condition: true
initial amount: NaN
is: P42765
is encoded by: hsa:10449
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR FAOXC226C227m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR GCHOLAte
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reversible: true
name: bile acid intracellular transport
kinetic law: MODEL1310110015#

metaR PPItr
kinetic law: MODEL1310110015#
is: SBO:0000185
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_0db31f0f_8da5_4d9b_bdbf_199c8bcb4882
is: Q99519
initial amount: NaN
name: NEU1
type: Species
is encoded by: hsa:4758
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR ACt2m
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#

metaM acgal c
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: CHEBI:28037
constant: false
name: N-acetyl-D-galactosamine
has only substance units: false
initial amount: NaN
is: HMDB00212
boundary condition: false
type: Species
initial concentration: 1.0

metaM HC02210 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
boundary condition: false
constant: false
type: Species
has only substance units: false
name: prostaglandin-d3
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM aicar e
initial amount: NaN
is: C04677
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: CHEBI:58475
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01517
constant: false

metaM L2aadp m
initial amount: NaN
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00510
is: SBO:0000247
type: Species
name: L-2-aminoadipate(1-)

metaR MMEm
type: Reaction
name: methylmalonyl-CoA epimerase/racemase
modifier: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#

metaM 2obut c
is: C00109
constant: false
is: HMDB00005
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16763
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
name: 2-Oxobutanoate

metaM so3 c
is: HMDB00240
constant: false
type: Species
has only substance units: false
is: CHEBI:17137
is: C00094
boundary condition: false
initial amount: NaN
name: Sulfite
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_10d7c531_51c1_4c5f_bd2d_db2f4b064b48
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ALDH9A1
is: P49189
is encoded by: hsa:223

metaM digalsgalside hs e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: http://identifiers.org/pubchem.compound/8384
initial amount: NaN
constant: false
is: C06127
name: Digalactosylceramidesulfate
type: Species

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR S4TASE4ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
reversible: true
reactant: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000000
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176

metaR RAI2
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110015#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110015#
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (9-cis)

http://identifiers.org/biomodels.db/MODEL1310110015#_79b04db5_9b60_4bc0_b9c9_cdeb15d15017
is: SBO:0000252
name: B4GALT2
initial amount: NaN
is: O60909
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8704

metaR FAOXC11C9m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR COAtp
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
name: coenzyme A transport, peroxisomal
product: MODEL1310110015#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110015#_2ea58896_e4d2_4941_b432_807e361bdb0c
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI971036_1_c
constant: false
is: SBO:0000252
is encoded by: hsa:AI971036
type: Species
initial concentration: NaN

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR B3GALT5g
reversible: false
type: Reaction
product: MODEL1310110015#
modifier: MODEL1310110015#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
name: Beta-1,3-galactosyltransferase 5
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ksi pre3 g
is: HMDB00175
notes: FORMULA: C93H152N6O67X CHARGE: -1
type: Species
name: keratan sulfate I biosynthesis, precursor 3
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
is: C00130
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_fd0adfd6_bed3_48b2_8034_bc78cc2266e0
constant: false
is: Q5T4W8
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
name: ST3GAL3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_51864da2_d13a_4276_a282_1206a8423b9b
name: SDHD
is: SBO:0000252
is: O14521
is encoded by: hsa:6392
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM ei11ecoa x
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
constant: false
name: 11-eicosenoylcoa
type: Species
is: SBO:0000247
initial amount: NaN

metaR ACHtn
kinetic law: MODEL1310110015#
reversible: true
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110015#_80a621a3_62f3_4302_874c_20610f37ae2b
has only substance units: false
initial amount: NaN
constant: false
is: P08195
boundary condition: true
is encoded by: hsa:6520
initial concentration: NaN
name: SLC3A2
type: Species
is: SBO:0000252

metaR NDPK2n
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
fast: false

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reversible: true
is: SBO:0000185
reactant: MODEL1310110015#
is described by: ECO:0000134
name: diphopshate transporter, mitochondrial
type: Reaction
product: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false

metaR GBA
reversible: false
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
modifier: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.45
product: MODEL1310110015#
name: Glucosylceramidase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110015#

metaR NTD7e
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
name: 5'-nucleotidase (AMP), extracellular
is described by: ECO:0000269
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
fast: false
is: SBO:0000176
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_3c7fab77_84e7_4c95_ba46_a0dbb5428906
boundary condition: true
type: Species
is: SBO:0000252
is: P18283
constant: false
is encoded by: hsa:2877
name: GPX2
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_6e4b8be1_82b4_4181_86dd_8c04e3139b7c
is: Q92536
is encoded by: hsa:9057
type: Species
has only substance units: false
name: SLC7A6
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR CMPSASn
name: CMP sialic acid synthase, nuclear
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
type: Reaction
product: MODEL1310110015#

metaM cspg e e
is: CHEBI:17568
is: SBO:0000247
initial amount: NaN
is: C00106
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
has only substance units: false
is: HMDB00300
boundary condition: false
constant: false
type: Species

metaM nicrns c
is: HMDB06809
initial amount: NaN
type: Species
is: CHEBI:58527
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
name: Nicotinate D-ribonucleoside
boundary condition: false
has only substance units: false

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM digalsgalside hs g
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/8384
initial concentration: 1.0
constant: false
has only substance units: false
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
type: Species
name: Digalactosylceramidesulfate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_afe93190_70fb_418f_9c2a_be5a51602b7c
is encoded by: hsa:51733
boundary condition: true
has only substance units: false
constant: false
type: Species
is: B3KNC1
name: UPB1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM m4mpdol U r
initial amount: NaN
is: CHEBI:37633
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110015#_5d008434_284c_4145_9327_125377c1e674
type: Species
is: Q5JPH6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: EARS2
boundary condition: true
is encoded by: hsa:124454
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_ed54f553_70e1_4887_aba4_5eaa62bebdec
initial concentration: NaN
type: Species
is: O75438
has only substance units: false
boundary condition: true
is encoded by: hsa:4707
initial amount: NaN
name: NDUFB1
constant: false
is: SBO:0000252

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_1dc82767_2044_46df_a83d_9da5d592013b
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: E9PD84
is encoded by: hsa:9468
initial concentration: NaN
is: SBO:0000252
name: PCYT1B

http://identifiers.org/biomodels.db/MODEL1310110015#_ab668611_f7ef_48b6_8ee0_9cd71354a7c5
name: AMPD2
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q01433
boundary condition: true
is encoded by: hsa:271
constant: false
initial amount: NaN
has only substance units: false

metaR S6T9g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110015#
is described by: ECO:0000000
modifier: MODEL1310110015#
type: Reaction
reversible: false
is: SBO:0000176

metaR GLUtr
product: MODEL1310110015#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
is described by: ECO:0000000
name: intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110015#_fb933726_daef_414d_80bc_0f4811a81cff
is: P11086
constant: false
name: PNMT
initial amount: NaN
is encoded by: hsa:5409
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR r0587
fast: false
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110015#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110015#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

metaM datp m
is: HMDB01532
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: dATP
is: C00131
initial concentration: 1.0
type: Species
is: CHEBI:61404

metaR r0122
product: MODEL1310110015#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reactant: MODEL1310110015#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110015#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000

metaR COAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: COA transporter, endoplasmic reticulum
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110015#
fast: false
reversible: true

metaM ksi deg20 l
initial concentration: 1.0
boundary condition: false
is: HMDB00143
is: CHEBI:12936
has only substance units: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
type: Species
name: keratan sulfate I, degradation product 20
initial amount: NaN
is: SBO:0000247
constant: false

metaR G14T13g
is: SBO:0000176
reactant: MODEL1310110015#
fast: false
product: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110015#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR DNDPt37m
product: MODEL1310110015#
type: Reaction
name: dUTP transport via dTDP antiport
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110015#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110015#
fast: false
reversible: false
reactant: MODEL1310110015#

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR NACHEX12ly
reactant: MODEL1310110015#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
product: MODEL1310110015#
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#

metaM ksii core2 pre5 g
is: HMDB00175
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: C00130
name: keratan sulfate II biosynthesis, precursor 5
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR MI14Ptn
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
is: SBO:0000185
product: MODEL1310110015#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: true

metaR FAOXC103C102m
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR COAtm
is: SBO:0000185
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
fast: false
reactant: MODEL1310110015#
is described by: ECO:0000269
name: CoA transporter
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110015#_d1640707_0c6b_4d55_a951_5d4e17306a38
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5293
boundary condition: true
has only substance units: false
name: PIK3CD
constant: false
initial amount: NaN
is: A7E2E0
type: Species

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: CHEBI:61404
boundary condition: false
is: C00131
type: Species
name: dATP
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_6886be2e_9d11_4bf0_b99e_3348dacad38c
is: P48426
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:5305
initial concentration: NaN
type: Species
name: PIP4K2A

metaR A4GALTg
product: MODEL1310110015#
name: Lactosylceramide 4-alpha-galactosyltransferase
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228

metaR PI45P3K
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
product: MODEL1310110015#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaR ACALDtm
fast: false
product: MODEL1310110015#
kinetic law: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110015#
reversible: true

metaR HISCAT1
kinetic law: MODEL1310110015#
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR C4STMO2Pr
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110015#
product: MODEL1310110015#
reversible: false
fast: false
name: C-4 methyl sterol oxidase
type: Reaction
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
kinetic law: MODEL1310110015#

metaM dcsptn1 e
constant: false
name: docosa-4,7,10,13,16-pentaenoic acid
is: http://identifiers.org/pubchem.compound/5282848
initial concentration: 1.0
is: HMDB13123
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
boundary condition: false

metaM amp x
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00020
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
is: CHEBI:456215
has only substance units: false
boundary condition: false
constant: false
name: AMP

metaM alpa hs c
type: Species
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52288
has only substance units: false
boundary condition: false
constant: false
name: lysophosphatidic acid
initial amount: NaN

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM hs deg18 l
is: HMDB06210
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 18
is: SBO:0000247
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
boundary condition: false
has only substance units: false

metaM ksi pre28 g
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 28
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00175
constant: false
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C213H341N15O176S8X CHARGE: -9

metaR CYOOm3
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
kinetic law: MODEL1310110015#
fast: false
is: SBO:0000185
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110015#
reactant: MODEL1310110015#

metaR DNDPt35m
product: MODEL1310110015#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110015#
name: dGDP transport via dADP antiport
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR ALDD2xm
reactant: MODEL1310110015#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110015#
fast: false
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110015#_0943e152_71cf_4545_b40b_b53c62227a2f
initial concentration: NaN
name: ATP5G2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:517
type: Species
constant: false
boundary condition: true

metaM doldp U r
is: SBO:0000247
is: CHEBI:15750
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
name: Dolichol diphosphate, human uterine homolog
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR ACOAD1fm
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
fast: false
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
type: Reaction
reversible: false
reactant: MODEL1310110015#
modifier: MODEL1310110015#
is: SBO:0000176

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR r0584
is described by: ECO:0000000
product: MODEL1310110015#
reactant: MODEL1310110015#
reversible: true
modifier: MODEL1310110015#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
kinetic law: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM 3mb2coa m
constant: false
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57344
is: HMDB01493
has only substance units: false
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110015#_acc94c64_70fd_4ebf_91d3_b854f08321a2
is encoded by: hsa:9514
constant: false
is: Q99999
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: GAL3ST1
has only substance units: false
initial concentration: NaN

metaR LNELDCCPT1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
is described by: ECO:0000269
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
reversible: false
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110015#_12360b90_f398_4780_9d30_4766ca453b80
initial amount: NaN
name: ST6GAL1
is: P15907
is encoded by: hsa:6480
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR PHEMEtm
reactant: MODEL1310110015#
reversible: true
is: SBO:0000185
fast: false
name: Heme transport to cytosol
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_e1c93d41_0ac4_4109_99c2_96e419c9f99b
type: Species
is: P30520
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: ADSS
is encoded by: hsa:159
initial amount: NaN

metaM dcsptn1 c
has only substance units: false
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5282848
type: Species
is: HMDB13123
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoic acid

metaM digalsgalside hs c
constant: false
name: Digalactosylceramidesulfate
boundary condition: false
is: http://identifiers.org/pubchem.compound/8384
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
initial concentration: 1.0

metaR BILIRUBt2
reactant: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110015#
name: bilirubin transport via bicarbonate countertransport
kinetic law: MODEL1310110015#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110015#_13d137f0_535b_4efa_80b6_4ec6a9d5db2d
name: _AI926493_1_m
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI926493
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_5a426e1c_8b82_4060_a8b5_4c3ce2113afa
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AK4
type: Species
is encoded by: hsa:205
initial amount: NaN

metaR PRO Dtde
type: Reaction
fast: false
product: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110015#
is described by: ECO:0000134
name: D-proline transport, extracellular

metaR COAtn
reactant: MODEL1310110015#
reversible: true
fast: false
kinetic law: MODEL1310110015#
is described by: ECO:0000000
product: MODEL1310110015#
type: Reaction
name: coenzyme A transport, nuclear
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR DM gpi sig er
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_9dbf33ee_4749_4586_b886_7c1ff3c48467
is: SBO:0000252
is: B4DIR8
is encoded by: hsa:64849
constant: false
name: SLC13A3
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110015#_25eee2b0_4e06_4b04_9c64_1b3c0919f6a5
boundary condition: true
is encoded by: hsa:64850
initial amount: NaN
is: SBO:0000252
is: Q8TBG4
initial concentration: NaN
has only substance units: false
name: AGXT2L1
constant: false
type: Species

metaR FACOAL161
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
name: fatty-acid--CoA ligase (hexadecenoate)
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
reactant: MODEL1310110015#
reversible: true
product: MODEL1310110015#

metaM chito2pdol U c
initial concentration: 1.0
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
has only substance units: false
is: CHEBI:12427
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_a34eeba6_3a28_4a55_b3fe_662516a6080c
has only substance units: false
boundary condition: true
name: LDHC
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:3948
type: Species

http://identifiers.org/biomodels.db/MODEL1310110015#_a357770b_25f2_4d80_b187_1942dd21b274
type: Species
initial concentration: NaN
is: Q96P26
is encoded by: hsa:93034
has only substance units: false
initial amount: NaN
name: NT5C1B
constant: false
is: SBO:0000252
boundary condition: true

metaR S6TASE1ly
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110015#
product: MODEL1310110015#
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110015#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110015#
is: SBO:0000176

metaR RAI1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
name: retinal isomerase (11-cis)
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
reversible: true

metaR LNELDCCPT2
product: MODEL1310110015#
reactant: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
name: carnitine transferase
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110015#_2bec9aab_3fca_482f_932f_98587df27168
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:23556
name: PIGN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_64fda08a_5980_4360_82f9_a8bfe3336b78
name: ATP5H
is: SBO:0000252
is encoded by: hsa:10476
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: A0PJH2
type: Species

metaM glyc m
name: Glycerol
constant: false
is: SBO:0000247
is: C00116
boundary condition: false
is: CHEBI:17754
is: HMDB00131
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110015#_26f3bf77_7166_4295_bd1a_e671d98edf17
type: Species
name: DGKI
initial amount: NaN
constant: false
is: O75912
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9162

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaR q10tm
type: Reaction
reactant: MODEL1310110015#
reversible: true
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110015#
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110015#

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
reversible: true
modifier: MODEL1310110015#
reactant: MODEL1310110015#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

metaR r1656
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110015#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110015#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110015#

http://identifiers.org/biomodels.db/MODEL1310110015#_8488c158_70d4_4396_8411_b84f835dbc6f
is: O95169
is encoded by: hsa:4714
boundary condition: true
type: Species
name: NDUFB8
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaM dttp e
is: HMDB01342
type: Species
initial concentration: 1.0
name: dTTP(4-)
constant: false
is: CHEBI:37568
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110015#_31421b1d_68b3_4e0d_bdf4_22e247efb6cb
has only substance units: false
has part: E9PB82
initial amount: NaN
is encoded by: hsa:3295
constant: false
is: SBO:0000297
name: ACAA1:HSD17B4:ACOX1
boundary condition: true
type: Species
initial concentration: NaN

metaR NMNS
name: NMN synthetase
type: Reaction
reversible: false
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
is described by: ECO:0000134
product: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
is described by: ECO:0000000
kinetic law: MODEL1310110015#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
reversible: true

metaR RE0830N
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110015#
name: RE0830
reactant: MODEL1310110015#

metaR FRDPtc
fast: false
type: Reaction
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110015#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000000
reversible: true

metaM 35diotyr c
initial concentration: 1.0
is: SBO:0000247
name: 3,5-diiodo-L-tyrosine
initial amount: NaN
is: HMDB03474
type: Species
constant: false
boundary condition: false
notes: FORMULA: C9H9I2NO3 CHARGE: 0 INCHI: InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 EHMN_ABBREVIATION: C01060
has only substance units: false
is: CHEBI:15768

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
product: MODEL1310110015#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#

metaM 34hpp c
is: CHEBI:36242
initial amount: NaN
initial concentration: 1.0
is: HMDB00707
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
name: 3-(4-hydroxyphenyl)pyruvate

http://identifiers.org/biomodels.db/MODEL1310110015#_d40fffb4_b207_4369_878d_13cd11eb6ec3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5238
name: PGM3
initial amount: NaN
is: B4DX94
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110015#_17550e96_57bb_4634_9767_297aa627e562
is: O00767
constant: false
initial concentration: NaN
is encoded by: hsa:6319
name: SCD
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaR r0580
is described by: ECO:0000000
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
reactant: MODEL1310110015#
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
modifier: MODEL1310110015#
product: MODEL1310110015#
is: SBO:0000176
reversible: true

metaM gly e
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Glycine
initial amount: NaN
type: Species
is: HMDB00123
initial concentration: 1.0
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
is: CHEBI:3339

metaM datp c
is: SBO:0000247
is: CHEBI:61404
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01532
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: C00131
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110015#_c0fb1ad8_0104_43d4_b148_6b1c49599f20
is encoded by: hsa:151531
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: O95045
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: UPP2

metaR GTHPm
type: Reaction
name: glutathione peroxidase, mitochondria
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110015#

metaR PLA2 2
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110015#
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2
fast: false
product: MODEL1310110015#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4

metaM paps g
initial amount: NaN
is: HMDB01134
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
is: CHEBI:58339

metaR OAGD3tg
is described by: ECO:0000000
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
type: Reaction
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
name: oagd3 hs intracellular transport
fast: false

metaR MI4PP
is: SBO:0000176
reactant: MODEL1310110015#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110015#
name: myo-inositol 4-phosphatase
reversible: false
fast: false
kinetic law: MODEL1310110015#
product: MODEL1310110015#
is version of: http://identifiers.org/ec-code/3.1.3.25
type: Reaction

metaR r1658
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110015#
product: MODEL1310110015#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110015#
is: SBO:0000185
reactant: MODEL1310110015#

metaR GSNt
modifier: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
name: guanosine facilated transport in cytosol

http://identifiers.org/biomodels.db/MODEL1310110015#_c5fd5ab9_0331_47d9_82d2_464a0c6ed7c0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5211
constant: false
has only substance units: false
boundary condition: true
name: PFKL
type: Species
is: Q7L2M7

metaR COAtg
product: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
name: CoA transport in Golgi via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110015#
reversible: true
reactant: MODEL1310110015#
is described by: ECO:0000000

metaM sphs1p c
initial amount: NaN
type: Species
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: SBO:0000247
is: HMDB00277
has only substance units: false
boundary condition: false
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_1b2676ab_f294_4a99_9a47_67cd7f3fa631
is encoded by: hsa:60490
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q96CD2
name: PPCDC
is: SBO:0000252
has only substance units: false

metaM tsul m
boundary condition: false
constant: false
name: thiosulfate(2-)
initial concentration: 1.0
initial amount: NaN
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16094

metaR RE3242R
reversible: true
product: MODEL1310110015#
fast: false
reactant: MODEL1310110015#
name: RE3242
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaR BAAT2x
is described by: ECO:0000269
reactant: MODEL1310110015#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
product: MODEL1310110015#
reversible: false
modifier: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#

metaM nrvnc e
type: Species
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
constant: false
is: SBO:0000247
name: nervonate
is: HMDB02368
is: CHEBI:32392
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM dttp c
initial amount: NaN
name: dTTP
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
type: Species
is: C00459
is: HMDB01342
has only substance units: false
boundary condition: false
is: CHEBI:37568
constant: false

metaM glc D c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:4167
initial amount: NaN
is: HMDB00122
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110015#_715cf60d_82aa_4d54_8d24_048a3a0d379a
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10786
is: O00476
name: SLC17A3
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM dtmp e
boundary condition: false
name: dTMP(2-)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:26999
is: HMDB01227
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaR r1659
product: MODEL1310110015#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110015#
is: SBO:0000185
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110015#_648c4d5b_5826_4275_a2b4_4f46143b030b
is encoded by: hsa:8639
boundary condition: true
initial amount: NaN
name: AOC3
constant: false
has only substance units: false
initial concentration: NaN
is: Q16853
type: Species
is: SBO:0000252

metaM l2n2m2mn l
is: CHEBI:12936
constant: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)

metaR MALTe
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
reactant: MODEL1310110015#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
is version of: http://identifiers.org/ec-code/3.2.1.20
is: SBO:0000176
name: alpha-glucosidase, extracellular
product: MODEL1310110015#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110015#_60c8b435_e8e7_4a55_8b1b_45d07f1ac022
initial amount: NaN
name: MTMR1
is encoded by: hsa:8776
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
is: Q13613

metaR HDCAtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110015#
type: Reaction
kinetic law: MODEL1310110015#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110015#
reversible: true
name: fatty acid transport via diffusion

metaM gdp m
name: GDP
type: Species
is: C00035
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58189
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM gly c
is: C00037
is: CHEBI:3339
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00123
is: SBO:0000247

metaM hs deg9 l
constant: false
initial concentration: 1.0
is: HMDB06355
is: CHEBI:18268
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: heparan sulfate, degradation product 9

http://identifiers.org/biomodels.db/MODEL1310110015#_678b5343_7eea_42cc_bb71_070c369a1f4f
is: G5E960
is encoded by: hsa:5331
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: PLCB3

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: HMDB00973
boundary condition: false
constant: false
is: CHEBI:43474
is: C00009
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaR 2DR1PP
type: Reaction
reversible: false
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is: SBO:0000176
product: MODEL1310110015#
is described by: ECO:0000000
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaR r0796
product: MODEL1310110015#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110015#
modifier: MODEL1310110015#
type: Reaction
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110015#

metaM etfox m
name: Electron transfer flavoprotein oxidized
notes: FORMULA: R CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:30825
has only substance units: false
type: Species
is: HMDB00573
is: SBO:0000247

metaR DUTPDPn
reversible: false
modifier: MODEL1310110015#
reactant: MODEL1310110015#
type: Reaction
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
is described by: ECO:0000269
product: MODEL1310110015#
is: SBO:0000176
kinetic law: MODEL1310110015#
fast: false
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23

http://identifiers.org/biomodels.db/MODEL1310110015#_2a91af6f_16ea_492b_b4e7_22be1fe5acce
is: SBO:0000252
name: ADSSL1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:122622
has only substance units: false
initial concentration: NaN
constant: false
is: B3KTV4

metaM nadh m
is: http://identifiers.org/pubchem.compound/3306
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00004
is: CHEBI:57945
is: HMDB01487
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110015#_cd41528b_bec2_4758_b0d9_e5fe65f3c3ed
is encoded by: hsa:6584
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC22A5
constant: false
is: O76082

metaR OAGD3te
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110015#
kinetic law: MODEL1310110015#
reversible: true
name: oagd3 hs transport
type: Reaction
reactant: MODEL1310110015#
is: SBO:0000185

metaM itp c
constant: false
is: SBO:0000247
is: CHEBI:57614
initial amount: NaN
boundary condition: false
type: Species
name: ITP(3-)
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
has only substance units: false

metaM HC02206 e
has only substance units: false
constant: false
name: prostaglandin C1(1-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
is: SBO:0000247
is: CHEBI:57399
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110015#_dbcbb452_8bde_447a_82b4_49b9fce8868c
initial amount: NaN
boundary condition: true
has only substance units: false
name: RPL36A
type: Species
initial concentration: NaN
is encoded by: hsa:6173
constant: false
is: SBO:0000252
is: P83881

metaM 4nph c
is: CHEBI:57917
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
type: Species
name: 4-nitrophenolate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01232

metaM nrvnc c
is: SBO:0000247
constant: false
name: nervonate
has only substance units: false
type: Species
boundary condition: false
is: HMDB02368
is: CHEBI:32392
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110015#
reactant: MODEL1310110015#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR LYStn
reversible: true
reactant: MODEL1310110015#
type: Reaction
product: MODEL1310110015#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110015#
name: L-lysine transport, nuclear
fast: false

metaM gdp n
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01201
initial amount: NaN
is: CHEBI:58189
has only substance units: false
is: SBO:0000247
type: Species
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM bilirub r
constant: false
initial amount: NaN
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false
name: bilirubin(2-)
boundary condition: false
initial concentration: 1.0
is: HMDB00054
is: SBO:0000247
type: Species

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is version of: http://identifiers.org/ec-code/2.7.8.29
reactant: MODEL1310110015#
kinetic law: MODEL1310110015#
is described by: ECO:0000269
modifier: MODEL1310110015#
product: MODEL1310110015#